Hub : Genes

VSTM4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1680	0.0360	5.8e-11	0.117	0.12	0.109	0.126	0.114	4.0e-14	2.1e-14	3.9e-13	4.1e-15	9.1e-14
2	GTEx	Artery Tibial	0.1487	0.0528	4.3e-03	0.001	NA	-0.003	NA	-0.001	2.7e-01	NA	8.5e-01	NA	4.1e-01
3	GTEx	Heart Left Ventricle	0.1566	0.0530	1.6e-03	0.060	NA	0.078	NA	0.072	4.2e-04	NA	5.8e-05	NA	1.1e-04
4	GTEx	Muscle Skeletal	0.0716	0.0302	6.0e-03	0.037	NA	0.027	NA	0.030	1.5e-04	NA	9.7e-04	NA	5.6e-04
5	GTEx	Spleen	0.4590	0.0950	6.4e-06	0.187	NA	0.198	NA	0.232	1.6e-05	NA	8.4e-06	NA	1.2e-06
6	GTEx	Testis	0.2750	0.0680	7.2e-06	0.135	NA	0.190	NA	0.222	1.4e-06	NA	7.6e-09	NA	3.3e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.4	2.2	4.9	0.4	0.7	-1.9	-1.7	0.9	-2.2
Bipolar Disorder or Schizophrenia	0.6	1.6	3.3	-1.2	-0.2	-1.3	-1.8	1.4	-1.0
Depressed Affect (Nagel 2018)	0.7	1.5	3.2	-0.6	-0.5	-0.7	-1.8	1.5	1.4
Depression (Nagel 2018)	0.5	0.8	1.3	1.0	1.1	-1.1	-0.9	0.4	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.6	0.6	1.3	-0.4	0.5	-0.6	-0.3
Neuroticism (Nagel 2018)	0.6	1.3	3.5	-0.8	-0.7	-0.4	-1.9	1.3	1.1
Schizophrenia (2018)	0.5	1.1	3.6	-1.9	-0.8	-0.1	-1.0	0.9	0.5
Schizophrenia vs Biploar Disorder	0.7	1.0	4.9	-0.5	-0.4	0.6	-0.4	0.4	2.2
Worry (Nagel 2018)	0.4	0.8	2.1	-0.3	-0.1	-0.0	-1.4	0.8	1.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	0.3	0.5	0.8	0.8	-0.0	1.0
Alzheimer’s Disease (in father)	0.7	0.8	2.0	-0.3	0.2	-0.9	-1.4	1.3	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	0.3	0.2	0.1	-0.5	0.7	0.2
Crohns Disease (2017)	1.3	2.8	9.3	-1.1	0.4	-0.7	-2.4	3.0	0.3
Irritable Bowel Disease (IBD)	0.6	1.5	4.5	-0.3	0.8	-1.0	-1.6	2.1	-0.3
Ulcerative Colitis (UC)	0.2	0.5	1.3	1.1	0.5	-0.7	-0.4	0.4	-0.6
Major Depression (MDD)	0.6	0.8	2.2	-0.1	-0.1	-0.2	-1.2	1.0	1.5
Reaction Time	0.4	0.7	1.7	-0.9	0.5	1.3	0.9	-0.9	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.2	0.4	1.1	-0.1	0.6	-0.4	0.4
Breast Cancer	0.3	0.8	3.4	1.8	0.4	-0.0	0.6	-0.5	-0.8
Ovarian Cancer	0.3	0.4	0.9	0.9	0.8	-0.3	0.3	-0.3	-0.7
Prostate Cancer	1.6	2.2	4.2	0.3	-0.1	2.0	1.7	-2.0	-1.5
Age at First Birth	0.7	1.1	3.1	0.7	1.8	-0.7	-0.7	1.1	0.6
Bipolar Disorder (2011)	0.6	0.5	1.4	-0.0	-0.1	-0.4	-1.1	1.2	0.7
Body Mass Index (BMI) (2010)	1.2	1.7	2.9	-0.9	-1.6	1.7	1.0	-1.6	0.0
Coronary Artery Disease (CAD)	0.5	0.6	2.0	-0.0	-0.9	0.6	0.2	-0.5	-1.4
Crohns Disease (2012)	0.8	1.3	4.4	-0.5	-0.2	-0.3	-1.7	2.1	-0.5
Mean Putamen Volume	1.9	2.2	3.4	-0.8	-1.3	1.9	1.7	-1.3	-1.6
Fasting Glucose	0.2	0.3	0.6	-0.5	0.3	0.5	-0.5	0.5	0.8
HbA1C	2.5	2.7	5.2	0.1	-1.8	2.3	1.6	-1.7	-1.6
HDL Cholesterol	0.2	0.3	1.5	-0.6	-0.1	-0.2	0.2	0.2	1.2
LDL Cholesterol	1.2	2.0	5.1	-1.6	-2.3	1.4	0.7	-0.9	-0.9
Lupus	1.6	2.4	3.9	-1.9	-2.0	-0.0	-1.9	1.7	0.7
Neuroticism (2016)	1.6	2.4	5.4	0.1	0.4	-2.2	-2.3	1.7	0.8
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.5	-0.1	0.5	0.3	-0.1	-0.2
Rheumatoid Arthritis	0.8	1.1	1.8	0.3	0.1	-1.3	-1.3	1.3	-1.2
Schizophrenia (2014)	0.4	0.8	2.0	-0.9	-0.6	-0.6	-1.4	1.2	-0.4
Triglycerides	0.7	1.1	4.0	-2.0	-0.9	1.3	-0.2	0.1	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.1	0.6	-0.3	-1.0	-1.8	1.7	0.2
Ulcerative Colitis	1.6	2.3	6.3	1.6	1.2	-2.5	-1.4	1.3	-0.1
Blood Eosinophil Count	1.4	10.6	17.4	-1.7	-3.4	4.2	3.7	-3.6	-2.2
Blood Platelet Count	7.2	83.7	141.6	-2.0	-9.6	9.2	11.2	-11.9	-7.3
Blood Red Count	0.1	0.8	2.6	-0.1	-0.1	1.6	1.4	-0.6	-0.5
Blood White Count	5.4	40.0	63.5	-1.9	-6.4	7.1	7.7	-8.0	-4.7
Heel T-Score	2.4	19.5	29.5	-3.0	-4.0	5.4	4.8	-4.8	-4.0
BMI	0.1	0.9	2.2	-1.5	-1.4	0.2	0.0	-0.2	1.0
Height	0.2	3.8	7.9	1.2	0.5	2.2	2.8	-2.8	-0.6
Waist Hip Ratio (WHR)	1.2	5.5	13.8	2.0	-0.8	1.3	3.5	-3.7	-0.9
Systolic Blood Pressure	1.0	5.2	11.3	-1.8	-1.2	1.9	2.7	-3.4	-2.1
Smoking Status	1.0	2.5	6.8	-0.3	-2.6	1.6	1.8	-1.4	-0.4
Allergy or Eczema	0.5	1.3	2.6	-1.6	0.6	1.3	-0.4	1.3	1.0
Cardiovascular Disease	0.5	1.6	4.3	-2.1	-0.2	0.9	1.1	-1.0	-1.5
Hypothyroidism (self reported)	0.1	0.1	0.4	-0.3	0.5	-0.0	-0.2	0.6	-0.1
Respiratory disease	1.2	2.6	8.9	0.1	3.0	-1.9	-1.2	1.3	0.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.9	0.2	-0.6	1.9	2.0	-1.6	0.1
Lung FEV1/FVC ratio	0.8	3.8	9.3	-3.0	-2.9	2.1	0.4	-0.6	0.3
Lung FVC	0.2	0.9	3.6	0.7	-0.6	-1.1	-0.1	0.0	-1.9
Neuroticism	0.2	0.4	1.7	-0.2	-0.7	0.3	-0.6	0.2	1.3
Chronotype (morning person)	0.5	1.1	2.4	-1.5	-0.6	1.1	-0.3	0.4	1.6
Hair Pigment	0.0	0.2	0.5	0.7	0.3	-0.1	-0.2	0.6	0.4
Tanning	0.1	1.5	3.0	-1.7	-1.7	-0.1	-1.2	0.9	0.9
Hand grip strength (left)	0.1	0.3	1.4	-0.1	0.2	1.2	0.4	0.2	0.2
Number of treatments/medications taken	0.3	0.6	3.3	-1.8	-0.2	0.3	-0.4	0.2	0.3
Average weekly spirits intake	1.8	2.2	6.9	-2.6	-1.6	1.6	-0.0	-0.0	1.0
Sensitivity / hurt feelings	1.4	2.4	4.4	-0.9	-1.5	-0.5	-2.1	1.6	2.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.0	0.8	0.3	-0.9	-1.0	0.2	-0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.4	0.6	-0.3	0.0	0.4	0.2
Relative age of first facial hair	0.8	1.6	7.0	-0.0	-0.9	0.9	0.7	-0.4	-2.7
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	8.3	1.0	2.2	-2.1	-0.9	1.0	2.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.5	-0.5	0.6	0.2	-0.1	-0.1
Ever had hysterectomy (womb removed)	0.9	1.1	2.1	-0.4	-1.2	1.4	1.0	-1.1	-0.7
Systolic blood pressure, automated reading	0.9	2.6	6.6	-2.6	-1.7	1.3	0.9	-1.4	-1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.8	0.8	-0.5	-0.3	0.2	0.5
Angina	1.0	1.3	5.1	-2.3	-0.5	0.9	-0.6	0.7	0.9
Medication for hormone replacement therapy	4.9	5.5	10.2	-1.7	1.4	-1.0	-2.9	2.9	3.2
Vitamin and mineral supplements	0.2	0.3	1.5	0.0	-0.3	-0.2	-0.2	0.0	1.2
Supplements: Zinc	0.3	0.3	1.2	-0.3	-1.1	0.5	-0.4	0.3	-0.1
Medication: Co-codamol	0.4	0.5	1.4	0.9	1.2	-0.1	0.3	-0.1	0.5
Medication: Metformin	0.5	0.7	1.4	-0.2	0.4	1.1	1.2	-0.9	0.7
Diabetes (father)	0.3	0.4	0.9	0.5	1.0	-0.7	-0.1	-0.1	0.6
Diabetes (mother)	1.2	1.6	4.0	-2.0	-0.0	-0.4	-1.3	1.4	1.4
Severe depression (siblings)	1.7	1.9	4.9	0.8	-0.1	1.1	2.1	-2.2	-0.4
Pack years adult smoking proportion	0.5	0.7	2.5	0.3	1.0	-0.8	0.2	-0.2	-1.6
Impedance of leg (right)	0.1	0.5	1.6	1.3	0.1	-0.2	0.6	-0.8	-0.6
Leg fat-free mass (left)	0.1	0.6	1.1	-0.8	-0.6	1.0	0.9	-1.0	0.1
Trunk fat percentage	0.5	1.8	5.8	0.2	-1.3	0.2	1.7	-2.4	-0.7
Hand grip strength (right)	0.2	0.4	1.9	-0.5	-0.1	1.4	0.2	0.3	0.5
Townsend deprivation index at recruitment	0.6	0.8	2.2	-0.3	-0.8	-0.4	1.4	-1.5	-0.1
Current tobacco smoking	0.2	0.4	1.5	-0.4	-1.2	0.1	0.2	0.0	-0.7
Average weekly fortified wine intake	0.4	0.5	0.9	-1.0	0.3	0.8	0.8	-0.7	-0.3
Maternal smoking around birth	1.5	2.2	3.5	-0.3	1.6	-1.2	-1.5	1.8	1.9
Fed-up feelings	0.2	0.4	1.1	0.4	0.2	-0.6	-0.7	0.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.8	1.3	1.0	-0.4	0.5	-1.1	-0.2
Relative age voice broke	0.9	1.4	5.7	0.5	0.6	-0.3	-0.8	1.0	-2.4
Taking other prescription medications	1.1	1.7	2.6	-0.3	1.6	-1.6	-1.3	1.4	1.2
Age when periods started (menarche)	0.1	0.3	0.7	-0.7	-0.9	0.1	-0.4	0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.5	-0.1	-1.2	0.8	-0.1	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	13.0	-1.0	-0.5	2.8	3.6	-3.5	-1.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.6	-0.1	-0.0	0.6	1.3	-1.2	-1.1
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.0	0.2	-1.0	-0.7	0.2	0.4
Serious illness, injury or assault to yourself	1.7	2.0	3.8	-1.0	0.3	-0.9	-1.7	1.9	1.9
High blood pressure	0.5	1.3	5.1	-2.2	-1.3	0.5	-0.2	-0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.8	-1.4	1.4	1.6	0.2	0.8	1.7
Multivitamins +/- minerals	0.6	0.8	1.5	0.9	1.2	-0.7	-0.7	1.1	-0.4
Stomach or abdominal pain in last month	1.8	2.3	5.1	-2.1	-0.9	2.3	0.2	0.1	1.8
Supplements: Glucosamine	1.3	1.6	3.3	0.3	0.4	-0.4	1.7	-1.8	-1.8
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.3	1.5	0.0	1.0	1.2	-1.1	0.3
Medication: Atenolol	0.5	0.6	1.7	0.3	0.5	-0.2	1.2	-1.3	-0.3
Medication: Levothyroxine sodium	0.1	0.3	1.3	-1.2	-0.1	0.0	0.1	0.4	-0.1
Sitting height	0.2	1.3	4.2	-2.0	0.1	0.3	-1.0	1.5	0.7
Chronic bronchitis/emphysema (father)	1.6	1.9	3.6	0.7	0.1	1.4	1.9	-1.7	-1.6
High blood pressure (mother)	0.5	0.8	2.6	1.1	0.2	-0.7	-0.2	0.3	1.6
Body mass index (BMI)	0.2	0.8	2.9	-1.7	-1.0	0.4	0.2	-0.5	0.4
Impedance of leg (left)	0.1	0.7	2.9	1.7	0.4	-0.8	0.4	-0.6	-0.3
Leg predicted mass (left)	0.1	0.7	1.3	-0.9	-0.6	1.1	0.9	-1.0	0.1
Trunk fat mass	0.5	1.9	5.6	-0.6	-1.3	0.7	1.8	-2.4	-0.4
Waist circumference	0.5	1.9	5.3	-0.4	-1.4	0.8	1.8	-2.3	-0.3
Number of incorrect matches in round	0.6	1.0	3.4	-1.8	-1.0	0.7	0.8	-0.8	-0.1
Past tobacco smoking	1.3	2.3	5.9	1.2	2.4	-2.0	-1.0	0.9	0.9
Alcohol usually taken with meals	0.4	0.6	1.4	0.2	-1.2	0.4	-1.0	0.9	-0.4
Nervous feelings	0.2	0.4	1.1	-0.6	-0.2	0.1	-1.0	0.9	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.6	1.6	0.5	-1.6	-1.1	0.5	-0.5
Hearing difficulty/problems with background noise	0.6	1.0	2.7	-0.5	1.3	0.0	-0.9	1.7	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.7	-0.1	0.2	0.1	-0.1	0.1
Had menopause	0.9	1.2	2.2	-0.1	-1.0	1.2	1.4	-1.5	0.3
Had other major operations	0.6	0.7	1.4	-0.9	-0.2	1.0	0.7	-0.5	1.2
Forced vital capacity (FVC)	0.2	0.9	2.6	-0.2	-0.0	0.4	1.3	-1.1	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	2.7	6.1	11.6	-1.3	-0.7	2.7	3.4	-3.3	-2.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.7	-0.2	0.5	-1.3	-1.3	0.6	-0.2
Qualifications: None of the above	2.4	5.2	12.7	-1.8	-3.6	3.0	1.5	-1.4	-1.5
Financial difficulties in last 2 years	0.5	0.7	2.9	1.7	-0.0	-0.6	0.2	-0.5	0.7
Mouth/teeth dental problems	2.1	3.2	5.5	-0.8	-0.6	1.7	2.3	-2.4	-2.1
Heart attack	0.7	0.9	2.2	-1.5	-0.2	0.5	1.1	-1.1	-0.8
Allergy	0.4	1.0	3.5	0.7	-1.9	-1.1	-0.4	-0.3	-0.9
Pain all over the body in last month	0.4	0.4	1.8	-0.4	-0.3	-0.1	-0.7	0.2	1.4
Diabetes (self-reported)	0.9	1.4	3.5	-0.5	-0.8	1.9	1.1	-0.8	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	5.5	1.4	2.4	-0.6	0.6	-0.4	-1.6
Medication: Ramipril	0.6	0.7	2.2	-1.5	-1.0	0.9	0.1	-0.1	0.5
Medication: Simvastatin	0.1	0.1	0.5	-0.7	-0.1	-0.2	-0.2	0.2	0.4
Fluid intelligence score	0.2	0.5	0.9	0.9	0.9	-0.4	0.4	-0.6	-0.8
Illnesses of siblings	0.6	0.8	2.3	1.4	1.5	-0.6	-0.2	0.3	-0.4
Neuroticism score	0.2	0.5	1.4	-0.3	-0.4	0.1	-1.2	0.7	0.9
Weight	0.2	1.2	2.4	-1.1	-0.7	1.1	1.3	-1.6	-0.1
Impedance of arm (right)	1.5	7.2	15.7	4.0	-0.1	0.1	3.1	-3.3	-2.5
Arm fat percentage (right)	0.3	1.1	3.0	-0.3	-1.3	0.1	1.2	-1.7	-0.8
Trunk fat-free mass	0.1	0.8	2.5	-1.6	-0.1	1.4	0.6	-0.4	0.4
Hip circumference	0.1	0.5	1.1	-1.0	-0.6	0.3	0.8	-1.0	-0.2
Time employed in main current job	0.5	0.6	1.7	0.5	-0.8	-1.3	-0.7	0.6	0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.7	0.6	0.1	0.5	-0.2	0.8
Father’s age at death	0.6	0.7	2.0	1.3	1.4	-0.1	-0.1	0.4	0.7
Worrier / anxious feelings	0.1	0.2	0.5	0.2	0.2	0.7	0.1	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.6	0.5	-0.5	1.6	1.2	-1.6	0.3
Falls in the last year	1.3	1.8	4.3	0.6	1.2	-1.6	-0.9	0.9	2.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.2	0.3	-0.3	-0.7	0.2	-0.2
Number of live births	0.8	1.1	2.7	1.5	0.2	-1.6	-1.1	0.7	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.9	-1.2	-1.0	1.1	1.4	-1.3	-1.7
Pulse rate	4.8	8.1	17.6	-0.4	0.6	-3.4	-4.2	4.0	1.8
Happiness	1.1	1.4	6.7	-0.2	-0.9	-0.2	-0.0	-0.8	-2.6
Noisy workplace	0.7	0.8	4.3	-0.5	-0.5	-0.4	-0.1	0.3	2.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.3	1.5	0.7	-2.1	-1.8	1.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.5	7.7	0.6	0.8	-1.8	-2.7	2.8	1.3
Mouth/teeth dental problems: Dentures	0.8	1.4	2.8	0.2	-0.4	-0.7	-1.5	1.7	1.6
Asthma	0.5	1.0	2.0	-0.9	1.4	-0.8	-1.1	1.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.5	-1.5	0.2	0.5	-0.4	0.5	1.9
Medication: Cholesterol lowering	0.3	0.5	1.1	-1.0	-0.6	1.1	0.6	-0.6	0.3
Depression (self-reported)	0.5	0.6	1.5	0.0	0.6	-0.5	-1.2	0.9	0.6
Medication: Lansoprazole	0.8	0.9	1.7	-0.3	-0.3	1.2	1.0	-1.0	-1.3
Prospective memory result	0.5	0.6	1.5	0.3	1.0	0.9	0.1	0.3	1.2
Lung cancer (father)	0.4	0.5	1.5	0.2	0.6	1.2	1.0	-0.4	0.3
Illnesses of mother	0.4	0.5	1.5	-0.5	-0.4	-0.2	0.4	-0.8	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	-0.8	0.2	0.6	0.7	-0.4	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.9	-0.5	0.6	0.3	-0.5	0.6
Impedance of arm (left)	1.3	6.1	13.2	3.6	-0.2	0.1	2.9	-3.3	-2.1
Arm fat mass (right)	0.3	1.2	3.1	-0.8	-1.1	0.6	1.3	-1.8	-0.3
Trunk predicted mass	0.2	0.9	2.4	-1.6	-0.1	1.4	0.7	-0.5	0.3
Standing height	0.3	3.4	7.6	1.0	0.2	2.0	2.8	-2.6	-1.0
Length of working week for main job	0.5	0.6	1.6	1.3	0.5	-0.4	-0.1	0.3	1.1
Exposure to tobacco smoke at home	1.1	1.3	3.5	1.0	1.4	-1.9	-0.6	0.5	-0.8
Breastfed as a baby	1.8	2.2	6.1	-2.5	-1.9	1.0	-0.7	0.9	1.1
Tense / ‘highly strung’	0.1	0.2	0.6	0.2	0.2	-0.5	-0.3	-0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.7	-1.0	-1.7	-0.4	-1.1	0.7	-0.2
Hair/balding pattern: Pattern 4	1.9	4.6	10.3	-0.0	0.8	-1.8	-3.0	3.2	2.1
Birth weight of first child	0.7	1.3	4.2	0.7	0.9	0.6	1.0	-0.9	-2.0
Peak expiratory flow (PEF)	1.3	3.0	9.1	-3.0	-2.3	1.7	0.5	-0.5	-0.8
Pulse wave reflection index	1.9	2.3	4.8	-0.1	-0.9	2.2	2.0	-2.0	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.3	0.3	-0.9	0.0	0.7	-1.3	-1.5
Loud music exposure frequency	1.0	1.1	2.9	1.2	1.3	-0.1	0.7	-0.3	1.7
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	10.2	1.8	1.7	-3.2	-2.0	1.3	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	0.1	-0.4	0.3	0.2	-0.5	1.1
Blood clot in the leg (DVT)	1.4	1.8	3.5	1.4	0.5	1.6	1.9	-1.5	-0.5
Medication: Paracetamol	0.4	0.6	1.5	-0.2	-0.7	1.2	0.8	-1.0	-0.0
Headache pain in last month	0.8	1.4	5.1	0.5	2.3	-0.6	0.2	-0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	1.3	1.1	-0.4	0.1	0.2	-0.2
Glaucoma (self-reported)	0.2	0.2	0.5	-0.3	0.3	0.7	-0.4	0.3	0.4
Gout (self-reported)	0.6	0.8	3.0	-0.6	-1.2	0.3	-0.2	-0.2	1.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.6	0.1	0.8	0.2	0.3	-0.8
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.3	0.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	-0.1	0.3	-1.0	-0.1	0.2	-0.8
Birth weight	0.3	0.7	1.6	-0.7	0.2	0.9	-0.5	1.3	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.4	0.5	-0.9	-0.4	0.4	0.2
High blood pressure (siblings)	0.4	0.5	2.2	-1.5	-0.1	0.1	0.6	-0.7	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.3	0.1	0.8	0.5	1.1	-0.7	-0.3
Body fat percentage	0.3	1.3	3.8	-0.3	-1.4	-0.0	1.3	-2.0	-0.6
Leg fat percentage (right)	0.4	1.5	3.7	-1.9	-1.8	0.4	0.6	-1.2	-0.1
Arm fat-free mass (right)	0.3	1.3	5.0	-2.2	-0.4	1.2	0.2	-0.1	1.1
Exposure to tobacco smoke outside home	1.8	2.5	6.7	1.3	2.0	-2.6	-1.2	1.0	-0.4
Comparative body size at age 10	0.0	0.1	0.2	-0.4	0.1	-0.1	-0.3	0.2	0.5
Number of full brothers	0.5	0.6	1.7	1.2	0.8	-0.0	0.2	0.3	1.3
Worry too long after embarrassment	0.2	0.4	1.1	0.1	-0.2	0.3	-0.7	0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.6	-0.5	0.2	0.5	-0.7	-0.2
Wheeze or whistling in the chest in last year	0.7	1.3	2.9	0.0	1.1	1.2	1.7	-1.4	0.4
Number of children fathered	0.5	0.6	1.8	-0.7	1.3	0.4	-0.2	0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.6	1.9	0.6	-0.2	0.4	0.1	-0.1
Age at first live birth	0.3	0.4	1.6	1.3	0.3	0.1	0.4	-0.1	-0.9
Pulse wave peak to peak time	0.3	0.3	0.6	-0.6	0.6	-0.6	-0.1	0.3	-0.7
Health satisfaction	0.5	0.6	1.1	-0.7	-1.1	-0.6	-1.0	0.7	0.5
Shortness of breath walking on level ground	0.7	0.9	2.1	0.7	0.4	-1.4	-1.1	0.8	0.8
Qualifications: College or University degree	0.2	0.7	2.1	1.0	1.5	-0.9	-0.5	0.4	-0.4
Eye problems/disorders: None of the above	1.3	1.5	3.4	1.8	-0.9	-1.1	-0.2	-0.3	-1.8
Mouth/teeth dental problems: Loose teeth	1.9	2.2	5.2	-0.9	0.2	-0.7	-2.0	2.3	1.6
Emphysema/chronic bronchitis	1.3	1.4	3.3	0.3	-0.1	1.0	1.8	-1.8	-1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	0.6	1.2	-1.1	-0.8	1.2	-0.3
Neck or shoulder pain in last month	0.4	0.5	2.1	-1.5	0.6	0.2	-0.4	0.5	0.5
Medication: Blood pressure	0.5	0.9	2.2	-1.5	-1.4	0.0	-0.9	0.5	0.1
Angina (self-reported)	0.7	0.9	3.4	-1.8	-0.6	0.9	-0.3	0.4	0.8
Migraine (self-reported)	0.7	0.9	1.7	-0.1	0.7	-1.0	-1.1	1.3	1.1
Medication: Ibuprofen	0.9	1.1	2.7	-1.6	0.2	0.5	-0.8	0.8	1.5
Medication: Allopurinol	1.0	1.3	3.7	-0.8	-1.8	0.2	-0.2	-0.2	1.9
Medication: Omeprazole	0.9	1.0	1.7	-0.9	-1.3	-1.3	-1.0	0.3	-1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.8	-0.6	0.2	0.9	0.3	-0.3	0.0
Mean time to correctly identify matches	0.2	0.4	0.9	-1.0	-0.6	0.9	0.3	-0.3	0.2
Heart disease (mother)	0.4	0.5	1.3	0.1	1.1	-0.6	-0.6	0.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-1.1	-1.3	0.1	1.2	-1.1	-0.4
Whole body fat mass	0.3	1.4	3.5	-0.8	-1.4	0.5	1.3	-1.9	-0.3
Leg fat mass (right)	0.3	1.2	2.5	-1.6	-1.4	0.6	0.9	-1.3	0.2
Arm predicted mass (right)	0.2	1.0	3.7	-1.9	-0.4	0.9	-0.1	0.1	1.2
Pulse rate, automated reading	3.7	12.0	22.3	0.4	1.2	-3.7	-4.5	4.7	3.8
Alcohol intake frequency.	0.3	0.8	1.9	-0.8	-0.8	1.0	0.5	-0.2	1.4
Comparative height size at age 10	0.8	4.5	8.6	0.8	-0.7	2.9	2.9	-2.9	-0.3
Number of full sisters	0.5	0.6	1.9	0.0	-1.4	1.0	0.1	0.2	0.8
Suffer from ‘nerves’	1.5	2.3	4.4	-0.1	0.8	-1.2	-2.0	1.7	2.1
Overall health rating	0.3	0.7	1.6	-0.0	1.0	0.1	1.2	-1.3	0.1
Chest pain or discomfort	0.1	0.2	0.7	-0.1	0.2	0.1	-0.2	0.3	0.9
Had major operations	0.6	0.7	1.9	-1.3	-1.4	0.7	-0.2	0.1	0.0
Age at last live birth	0.3	0.4	1.3	0.2	-0.1	-0.7	-0.8	1.2	-0.2
Family relationship satisfaction	0.6	0.8	3.0	0.4	0.2	0.0	0.8	-0.8	-1.7
Leg pain on walking	2.8	3.5	7.6	0.5	0.5	-1.8	-2.7	2.8	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	0.6	1.2	-0.7	-0.9	1.0	1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.1	0.3	0.7	-1.4	-1.6	1.7	-0.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	7.2	-0.2	-0.0	0.6	2.4	-2.7	-1.8
Medication: Aspirin	0.3	0.4	1.4	-0.9	-0.0	1.2	0.3	-0.2	0.3
Supplements: Vitamin C	1.0	1.2	3.8	-0.1	0.8	0.1	1.1	-1.1	-2.0
Knee pain experienced in last month	0.7	1.2	2.7	-0.5	-1.2	0.8	1.3	-1.6	-0.5
Hypertension (Self-reported)	0.5	1.3	4.5	-2.1	-1.5	0.3	-0.3	-0.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.2	-0.5	-0.6	-0.6	-1.5	1.2	-0.9
Illnesses of father: Heart disease	2.0	2.7	5.3	-0.7	1.4	-2.3	-1.9	2.0	0.9
Illnesses of siblings: Diabetes	0.5	0.6	2.6	-0.5	-1.6	0.6	0.4	-0.3	0.7
Smoking status: Previous	0.9	1.4	2.6	0.1	-1.3	1.6	1.2	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.7	0.9	1.9	-0.6	-0.2	0.2	0.2
Whole body fat-free mass	0.1	0.7	1.8	-1.4	-0.4	1.1	0.6	-0.6	0.4
Leg fat-free mass (right)	0.1	0.4	0.7	-0.6	-0.4	0.8	0.7	-0.8	0.1
Arm fat percentage (left)	0.3	1.0	2.6	-0.5	-1.5	-0.0	1.0	-1.6	-0.3
Average weekly red wine intake	0.4	0.6	1.9	1.4	0.6	-0.9	-0.1	-0.0	-0.4
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.7	0.3	0.1	1.5	1.7	-1.9	-1.6
Mood swings	0.3	0.5	1.3	-0.6	0.1	0.1	-1.1	0.9	0.6
Loneliness, isolation	1.6	2.2	5.0	0.4	-0.2	-1.4	-2.2	1.8	1.5
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.5	0.4	-0.7	-0.5	0.2	1.1
Ever had bowel cancer screening	1.0	1.1	3.6	0.6	-0.1	-0.2	-1.1	1.2	1.9
Diabetes diagnosed by doctor	0.9	1.4	3.1	-0.4	-0.9	1.8	1.4	-1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.9	0.7	-0.4	-1.4	-2.0	1.7	1.2
Friendships satisfaction	0.5	0.7	1.6	0.3	1.0	-0.8	0.4	-0.6	-1.3
Qualifications: nursing, teaching	0.4	0.7	2.5	0.2	1.6	0.5	-0.6	0.8	0.6
Commuting to job workplace: Walk	2.4	2.6	5.1	-1.1	-2.2	2.2	1.0	-0.5	1.8
Eye problems/disorders: Cataract	1.6	1.9	3.9	-2.0	0.3	0.1	-1.4	1.8	1.4
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.3	-0.0	1.1	-1.5	-2.1	2.3	1.4
Medication for cholesterol	0.3	0.4	0.8	0.8	-0.8	0.1	0.3	-0.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.6	0.9	-0.4	1.2	1.3	-1.0	-0.5
Back pain experienced in last month	2.0	2.9	5.1	-1.7	-0.4	2.3	1.9	-1.9	-1.2
Mineral and other dietary supplements	0.3	0.3	0.9	-0.1	0.5	-0.0	-0.6	0.9	0.8
Breast cancer (self-reported)	0.5	0.6	1.6	0.9	1.3	-0.1	0.5	-0.2	1.0
Asthma (self-reported)	0.5	1.0	2.7	-0.7	1.6	-0.9	-1.0	1.1	-0.3
Osteoporosis (self-reported)	0.7	0.8	2.4	-0.4	-1.0	0.4	-0.8	0.7	1.6
Osteoarthritis (self-reported)	0.5	0.6	3.1	-0.7	-0.2	0.1	0.1	0.0	1.8
Medication: Aspirin	0.5	0.6	1.7	-1.1	-0.4	1.3	0.5	-0.5	0.2
Medication: Gliclazide	1.2	1.3	3.0	-0.8	-1.4	1.7	1.2	-0.8	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.2	-0.3	0.7	0.5	-0.7	0.5
Smoking status: Current	0.6	1.0	3.4	-1.0	-1.8	0.6	0.6	-0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	-0.5	1.0	-0.9	-1.0	1.3	0.6
Whole body water mass	0.1	0.7	1.8	-1.4	-0.3	1.2	0.6	-0.6	0.3
Leg predicted mass (right)	0.1	0.4	0.6	-0.6	-0.4	0.8	0.7	-0.8	0.1
Arm fat mass (left)	0.3	1.3	3.3	-1.0	-1.1	0.5	1.4	-1.8	-0.2
Number of self-reported non-cancer illnesses	0.4	0.8	2.3	-0.8	1.5	-1.1	-0.5	0.3	0.3
Average weekly champagne plus white wine intake	0.7	0.9	2.7	1.3	-0.8	-0.2	-0.7	0.1	-1.6
Miserableness	0.1	0.1	0.4	0.2	-0.3	-0.1	-0.4	0.2	0.6
Guilty feelings	0.8	1.1	2.0	0.3	0.7	-1.0	-1.4	1.4	1.1
Wears glasses or contact lenses	0.6	0.7	1.7	-1.3	-1.3	0.4	-0.5	0.4	0.1
Ever taken oral contraceptive pill	0.8	0.9	2.6	-1.0	-0.6	0.1	-1.1	1.6	-0.5
Hearing aid user	0.7	0.8	3.7	-0.1	-0.6	-0.7	0.2	-0.0	1.9
Mother’s age at death	0.1	0.2	0.4	-0.0	-0.6	0.5	-0.2	-0.0	-0.7
Financial situation satisfaction	0.6	0.8	2.5	1.0	-0.0	-1.0	-0.1	-0.2	-1.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	-1.0	-1.3	-0.7	-1.2	0.6	0.7
Commuting to job workplace: Public transport	0.5	0.5	1.8	0.0	0.1	-0.8	-1.3	0.9	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	1.7	-0.6	-0.2	1.3	0.1	-0.1	0.4
Medication: Blood pressure	0.3	0.6	1.5	0.5	-0.0	0.5	1.2	-1.0	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.8	-1.7	-0.3	1.0	0.1	-0.3	0.4
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.2	0.2	-0.4	0.2	-0.0	-0.1	0.0
High cholesterol (Self-reported)	0.3	0.6	2.5	-1.6	-0.4	0.7	0.1	-0.4	0.0
Medication: Bendroflumethiazide	0.7	1.0	2.2	-1.0	-0.2	-0.7	-1.5	1.4	0.6
Medication: Paracetamol	0.3	0.5	1.6	-0.8	-0.8	1.3	-0.0	0.1	0.3
Medication: Lisinopril	1.2	1.6	3.1	0.2	-0.8	0.6	1.5	-1.7	-1.8
Medication: Atorvastatin	2.1	2.6	5.3	-0.5	-1.0	2.1	2.1	-2.3	-0.6
Illnesses of father: High blood pressure	0.3	0.3	0.9	0.1	-0.9	-0.9	-0.4	0.2	0.1
Alcohol drinker status: Never	0.7	0.8	3.9	-0.5	0.1	0.8	0.3	0.2	2.0
Ever smoked	0.7	1.2	4.8	-0.9	-2.2	0.5	-0.8	0.8	0.0
Basal metabolic rate	0.1	0.7	1.4	-1.2	-0.4	1.1	0.8	-0.9	0.2
Leg fat percentage (left)	0.3	1.2	2.9	-1.7	-1.7	0.1	0.5	-1.1	-0.1
Arm fat-free mass (left)	0.2	1.1	3.9	-2.0	-0.5	1.3	0.6	-0.6	0.3
Number of operations (self-reported)	0.4	0.6	2.1	-0.7	-0.2	-0.3	-0.8	0.7	1.5
Average weekly beer plus cider intake	0.4	0.5	1.1	-0.2	0.6	-0.6	0.9	-0.7	-1.1
Irritability	0.1	0.1	0.4	-0.7	-0.1	-0.2	-0.4	0.3	0.2
Risk taking	0.2	0.3	0.7	0.8	0.1	-0.8	0.0	-0.1	0.5
Ever had prostate specific antigen (PSA) test	2.2	2.5	6.8	0.3	1.5	-2.6	-1.7	1.7	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.8	-0.1	-0.7	-0.2	0.1	-0.8
Age started oral contraceptive pill	3.0	3.7	7.1	-0.6	-2.7	1.9	1.8	-1.7	-2.3
Diastolic blood pressure, automated reading	0.9	2.9	6.2	-1.0	-2.5	1.1	1.4	-2.1	-1.7
Ever depressed for a whole week	0.3	0.4	1.2	-1.1	0.1	-0.5	-0.8	0.2	-0.0
Unable to work because of sickness or disability	0.9	1.1	2.9	-1.1	-0.5	-1.7	-0.9	0.4	1.2
Commuting to job workplace: Cycle	0.3	0.4	1.3	-0.0	-0.8	-0.4	-0.2	0.3	-1.1
Myopia	0.9	1.4	4.0	1.3	0.6	-2.0	-1.0	0.7	-0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.7	2.2	1.0	-0.4	0.1	0.2	0.3
Cholesterol lowering medication	0.1	0.2	0.6	-0.8	-0.1	0.2	-0.2	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.4	-1.0	-1.6	-0.8	-0.8	0.3	-0.6
Pain experienced in last month	0.5	0.8	1.9	0.6	-0.6	-0.9	-1.2	1.4	0.2
Supplements: Calcium	0.3	0.3	1.2	0.5	-1.1	-0.5	-0.0	-0.3	-0.4
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.8	1.0	-0.6	0.4	-0.7	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	-1.4	-0.1	0.4	0.7	-0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.7	1.6	0.8	1.1	1.7	-1.2	-0.2
Heart disease (siblings)	0.7	0.8	2.1	-1.3	-0.1	1.4	0.8	-0.4	-0.6
Alcohol drinker status: Previous	0.9	1.0	2.3	0.3	-1.0	0.7	1.5	-1.3	-0.4
Pack years of smoking	0.5	0.8	3.2	0.2	0.8	-0.9	0.0	-0.2	-1.8
Impedance of whole body	0.5	2.8	8.0	2.8	0.1	-0.5	1.6	-1.9	-1.4
Leg fat mass (left)	0.3	1.2	2.2	-1.5	-1.5	0.5	0.9	-1.3	0.2
Arm predicted mass (left)	0.2	0.9	3.5	-1.9	-0.3	1.2	0.4	-0.3	0.7