Hub : Genes

WDFY4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.107	0.0382	0.0028	0.075	NA	0.059	NA	0.072	2.1e-06	NA	2.5e-05	NA	3.6e-06
2	GTEx	Spleen	0.385	0.1200	0.0024	0.004	NA	0.001	NA	0.030	2.5e-01	NA	3.0e-01	NA	5.8e-02
3	GTEx	Whole Blood	0.139	0.0540	0.0075	0.097	NA	0.091	NA	0.091	3.1e-09	NA	9.3e-09	NA	9.5e-09
4	NTR	Blood	0.155	0.0245	0.0000	0.070	0.083	0.084	0.095	0.090	1.6e-21	2.0e-25	1.1e-25	5.7e-29	1.3e-27
5	YFS	Blood	0.229	0.0289	0.0000	0.144	0.168	0.184	0.179	0.174	1.3e-44	1.3e-52	6.3e-58	4.1e-56	2.0e-54

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	3.1	-0.1	-0.3	0.6	1.8	0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	-0.3	-1.0	0.6	1.4	0.5
Depressed Affect (Nagel 2018)	0.4	0.7	1.5	-0.3	0.9	1.2	0.9	0.7
Depression (Nagel 2018)	1.2	1.8	4.2	-2.0	-0.2	1.1	1.9	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	-0.7	-0.6	-1.1	-0.5	-0.5
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.7	0.4	0.9	0.7	0.1
Schizophrenia (2018)	0.1	0.3	1.3	-0.3	-1.1	0.1	0.3	0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.3	0.6	0.1	-0.4	-0.1
Worry (Nagel 2018)	0.2	0.4	1.3	-1.1	0.4	0.4	0.6	-0.4
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	-1.1	-0.2	0.4	0.2	-0.4
Alzheimer’s Disease (in father)	0.8	0.9	1.1	0.9	0.9	0.9	1.0	0.9
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.6	0.1	0.6	0.6	-0.2
Crohns Disease (2017)	0.0	0.1	0.4	-0.1	-0.0	0.6	-0.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.4	-0.8	0.5	0.1	-0.2
Ulcerative Colitis (UC)	0.2	0.3	1.0	-0.4	-1.0	0.3	0.7	-0.1
Major Depression (MDD)	0.4	0.5	1.3	-0.8	0.6	-0.2	1.1	-0.2
Reaction Time	0.4	0.8	1.2	0.9	0.4	0.7	1.1	1.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.0	-0.3	-0.2	-0.3	-0.1
Breast Cancer	0.3	0.7	1.4	-0.9	-0.4	-1.2	-0.7	-0.9
Ovarian Cancer	0.2	0.2	0.7	0.1	0.3	0.4	0.8	0.5
Prostate Cancer	1.3	1.8	3.6	-0.0	-0.1	1.4	1.9	1.9
Age at First Birth	0.6	0.9	1.7	-0.0	0.6	-1.3	-1.2	-1.0
Bipolar Disorder (2011)	1.3	1.2	3.7	1.5	1.9	-0.2	0.4	0.2
Body Mass Index (BMI) (2010)	1.0	1.3	4.3	-1.5	-2.1	-0.2	0.1	-0.2
Coronary Artery Disease (CAD)	1.4	1.7	4.8	2.2	0.4	-1.2	-1.3	-0.8
Crohns Disease (2012)	0.3	0.5	1.4	-0.8	-1.2	0.7	0.1	-0.2
Mean Putamen Volume	1.7	1.9	2.9	-0.6	-1.0	1.6	1.7	1.7
Fasting Glucose	0.9	1.0	2.8	-1.7	-1.1	-0.9	-0.5	-0.4
HbA1C	2.2	2.4	4.5	0.4	-1.1	1.5	2.0	2.1
HDL Cholesterol	0.9	1.4	2.8	1.1	1.0	-1.0	-1.7	-1.2
LDL Cholesterol	0.2	0.3	1.4	0.1	-1.2	-0.1	-0.2	-0.3
Lupus	4.6	6.9	17.1	2.2	0.3	4.1	2.0	2.9
Neuroticism (2016)	0.3	0.4	1.4	0.1	0.6	-0.2	-0.1	-1.2
Primary Biliary Cirrhosis	0.7	1.0	3.2	1.8	0.3	1.0	-0.5	0.5
Rheumatoid Arthritis	0.6	0.9	2.5	0.6	0.6	-0.6	-1.6	-0.8
Schizophrenia (2014)	0.2	0.5	1.2	0.0	-0.6	0.7	1.1	0.8
Triglycerides	4.0	6.6	11.8	-1.0	-1.4	-2.8	-3.2	-3.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.1	-1.4	-0.4	0.3	0.1	-0.2
Ulcerative Colitis	0.1	0.2	0.4	0.2	-0.2	0.7	0.6	-0.3
Blood Eosinophil Count	0.1	1.1	2.8	1.2	-1.7	-1.0	-0.3	-0.0
Blood Platelet Count	1.6	18.1	88.0	-1.5	-9.4	-0.2	-0.0	-0.5
Blood Red Count	0.1	1.3	2.8	-1.7	-1.6	0.0	0.0	-1.1
Blood White Count	1.7	12.3	50.1	-3.3	-7.1	-0.2	0.1	-0.6
Heel T-Score	0.9	7.4	29.9	-1.8	-5.5	1.4	1.4	0.3
BMI	0.3	1.6	4.0	-2.0	-1.9	-0.3	-0.2	-0.5
Height	0.1	1.4	5.7	0.0	0.2	-2.4	-1.0	-0.3
Waist Hip Ratio (WHR)	0.0	0.2	0.7	0.1	-0.8	-0.4	0.1	0.1
Systolic Blood Pressure	0.5	2.5	9.5	-1.6	-3.1	0.2	0.5	0.3
Smoking Status	0.4	0.9	3.8	-0.3	-2.0	0.3	-0.4	-0.4
Allergy or Eczema	1.0	2.5	4.3	0.5	1.1	-1.7	-2.1	-2.0
Cardiovascular Disease	0.5	1.6	5.3	-1.6	-2.3	0.2	0.5	0.2
Hypothyroidism (self reported)	0.2	0.4	0.8	0.2	0.9	0.4	0.7	0.6
Respiratory disease	2.1	4.6	9.1	-0.9	0.1	-2.9	-2.2	-3.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	-0.6	-0.9	0.5	-0.1	0.0
Lung FEV1/FVC ratio	0.3	1.6	5.1	-1.2	-2.3	-0.0	-0.6	-1.1
Lung FVC	0.3	1.4	5.2	-0.8	-2.3	1.0	0.5	0.2
Neuroticism	0.2	0.6	1.1	-0.8	0.1	0.9	1.1	0.6
Chronotype (morning person)	0.5	1.1	1.9	1.2	1.4	0.6	0.9	1.0
Hair Pigment	0.0	1.0	2.7	1.6	1.3	0.6	0.0	0.5
Tanning	0.0	0.0	0.2	0.1	0.0	0.4	-0.1	0.0
Hand grip strength (left)	0.6	1.6	2.9	-1.7	-0.9	-1.3	-0.8	-1.4
Number of treatments/medications taken	0.2	0.3	1.3	-0.4	-1.1	0.0	-0.1	0.1
Average weekly spirits intake	3.9	4.8	6.8	-2.4	-2.6	-2.1	-1.6	-2.2
Sensitivity / hurt feelings	0.6	1.0	2.5	1.4	1.6	0.7	-0.1	0.0
Frequency of depressed mood in last 2 weeks	1.7	2.3	4.9	-2.2	-0.7	1.1	2.1	0.6
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-1.4	-0.3	-1.0	-0.8	-0.7
Relative age of first facial hair	0.6	1.2	2.5	-0.6	-1.1	-0.6	-1.1	-1.6
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.2	-0.9	0.5	-1.3	-2.1	-1.8
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.5	2.1	1.1	1.3	1.1	1.2
Ever had hysterectomy (womb removed)	1.0	1.1	2.1	-0.3	-1.0	1.0	1.3	1.4
Systolic blood pressure, automated reading	0.7	1.9	7.9	-1.2	-2.8	0.1	0.1	0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.5	0.8	1.2	-0.5	-0.5	-0.0
Angina	0.5	0.6	1.4	1.0	0.5	-0.3	-1.2	-0.6
Medication for hormone replacement therapy	0.7	0.8	3.4	0.3	1.8	0.7	0.2	-0.1
Vitamin and mineral supplements	0.6	0.8	2.9	-1.7	-1.0	-0.1	0.3	-0.1
Supplements: Zinc	2.7	3.0	6.3	0.8	0.5	2.5	2.2	1.7
Medication: Co-codamol	0.3	0.4	1.1	0.7	1.1	-0.3	-0.5	-0.1
Medication: Metformin	0.2	0.3	0.5	0.4	0.4	0.7	0.6	0.7
Diabetes (father)	1.8	2.2	3.2	1.5	1.8	1.6	1.1	1.3
Diabetes (mother)	0.4	0.5	1.1	0.4	-0.1	-0.4	-0.9	-1.1
Severe depression (siblings)	0.5	0.6	1.4	0.2	-0.2	0.7	1.2	0.9
Pack years adult smoking proportion	0.6	0.8	1.8	-0.2	-0.7	-1.3	-0.9	-1.0
Impedance of leg (right)	0.4	2.1	5.0	1.0	-0.1	-1.6	-2.2	-1.4
Leg fat-free mass (left)	0.1	0.5	1.2	-1.1	-0.9	-0.0	0.8	0.3
Trunk fat percentage	0.4	1.6	6.0	-1.0	-2.4	-0.8	-0.7	-0.3
Hand grip strength (right)	0.0	0.1	0.3	-0.6	-0.0	-0.2	0.4	-0.1
Townsend deprivation index at recruitment	0.2	0.2	0.9	0.3	-1.0	0.2	0.1	-0.2
Current tobacco smoking	0.1	0.1	0.3	0.3	-0.5	-0.1	-0.1	-0.5
Average weekly fortified wine intake	0.8	0.9	2.5	0.2	0.2	-1.6	-1.1	-0.9
Maternal smoking around birth	0.3	0.4	1.4	-0.1	1.2	0.4	0.5	-0.3
Fed-up feelings	0.2	0.3	0.9	-0.9	0.3	0.4	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.0	-2.0	-1.1	-0.9	-0.1	-1.1
Relative age voice broke	0.4	0.7	1.2	0.7	0.7	0.7	0.9	1.1
Taking other prescription medications	0.3	0.4	0.7	0.2	0.4	-0.8	-0.8	-0.7
Age when periods started (menarche)	0.8	2.0	5.4	2.3	0.8	1.5	0.6	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.9	-0.7	-0.9	0.6	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	8.6	-1.3	-2.9	-1.8	-1.4	-1.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	-0.2	-0.8	0.9	1.4	1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.9	-1.4	-0.2	-0.8	0.1	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.4	0.8	0.4	0.0	-0.3
High blood pressure	0.7	2.0	5.1	-1.4	-2.2	-0.9	-1.1	-1.0
Hayfever, allergic rhinitis or eczema	1.4	3.1	6.0	-0.4	0.8	-2.3	-2.0	-2.5
Multivitamins +/- minerals	0.6	0.8	2.9	0.9	1.7	0.1	-0.0	-0.4
Stomach or abdominal pain in last month	0.7	0.8	1.3	0.8	0.4	1.0	1.1	1.1
Supplements: Glucosamine	1.4	1.9	3.0	0.0	-1.4	-1.6	-1.7	-1.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	0.5	0.7	-0.0	0.4	0.7
Medication: Atenolol	1.4	1.8	4.3	-2.1	-1.7	-0.9	-0.4	-0.7
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.2	-0.3
Sitting height	0.1	0.7	1.3	0.8	1.2	0.7	0.3	0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	-1.1	-1.2	-0.6	0.5	0.7
High blood pressure (mother)	0.4	0.5	1.1	0.3	0.5	-0.6	-1.1	-0.9
Body mass index (BMI)	0.6	2.6	6.6	-2.4	-2.6	-0.5	-0.0	-0.4
Impedance of leg (left)	0.3	1.4	2.9	1.5	0.7	-1.0	-1.7	-0.7
Leg predicted mass (left)	0.1	0.5	1.3	-1.1	-0.9	-0.0	0.7	0.3
Trunk fat mass	0.5	2.2	7.3	-1.4	-2.7	-1.0	-0.7	-0.4
Waist circumference	0.5	1.9	5.6	-1.6	-2.4	-1.0	-0.3	-0.3
Number of incorrect matches in round	2.1	3.5	7.5	1.5	-0.6	2.7	1.3	2.4
Past tobacco smoking	0.3	0.6	2.2	-0.3	1.5	0.1	0.8	0.2
Alcohol usually taken with meals	1.0	1.6	3.3	1.8	1.3	1.1	0.7	1.2
Nervous feelings	0.1	0.1	0.3	-0.6	-0.0	0.5	0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.6	-1.6	-0.4	-1.2	-0.6	-1.0
Hearing difficulty/problems with background noise	0.2	0.3	1.5	0.1	1.2	-0.2	0.0	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.0	-0.0	0.4	0.7	0.1
Had menopause	0.4	0.5	1.1	0.4	-0.6	0.7	0.7	1.0
Had other major operations	0.1	0.1	0.2	-0.3	-0.0	-0.5	0.1	-0.1
Forced vital capacity (FVC)	0.2	0.7	2.6	-0.8	-1.6	0.2	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	9.1	-0.9	-3.0	-2.0	-1.9	-2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-1.1	-0.9	-0.1	-0.0	-1.1
Qualifications: None of the above	1.4	2.9	5.9	0.2	-2.2	2.4	1.1	1.6
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.6	0.1	-0.5	0.0	-0.0
Mouth/teeth dental problems	1.2	1.8	3.7	-0.5	-1.8	0.9	1.9	1.1
Heart attack	1.7	2.1	6.2	-1.5	-2.5	0.8	1.0	0.8
Allergy	1.1	2.5	5.0	-0.3	-1.2	2.2	1.4	1.9
Pain all over the body in last month	1.2	1.2	2.7	-1.1	-0.5	1.0	1.7	1.1
Diabetes (self-reported)	0.1	0.2	0.3	0.5	0.1	0.6	-0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.8	-0.1	0.9	-0.5	0.0	-0.1
Medication: Ramipril	1.0	1.2	2.4	-0.3	-1.1	-1.6	-1.4	-0.7
Medication: Simvastatin	0.1	0.1	0.3	-0.4	-0.5	-0.2	-0.2	-0.6
Fluid intelligence score	0.1	0.2	0.4	-0.2	-0.2	0.4	0.6	0.6
Illnesses of siblings	0.7	1.0	3.4	-1.9	-0.1	0.5	1.0	0.5
Neuroticism score	0.1	0.1	0.4	-0.2	0.6	-0.2	-0.0	-0.4
Weight	0.3	1.6	4.3	-1.6	-2.1	-1.0	-0.3	-0.3
Impedance of arm (right)	0.6	2.6	6.5	2.6	0.8	-1.2	-1.9	-0.7
Arm fat percentage (right)	0.4	1.7	5.0	-1.4	-2.2	-1.0	-0.7	-0.6
Trunk fat-free mass	0.1	0.5	1.1	-1.1	-1.0	-0.3	0.5	0.2
Hip circumference	0.3	1.2	2.8	-1.6	-1.7	-0.7	-0.2	-0.1
Time employed in main current job	0.5	0.6	1.0	0.9	1.0	-0.7	-0.8	-0.0
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-0.7	-0.0	-0.8	-1.2	-1.0
Father’s age at death	0.3	0.4	1.0	0.1	1.0	0.5	0.4	0.7
Worrier / anxious feelings	0.2	0.3	0.8	-0.7	0.1	0.1	0.9	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.6	-0.4	-1.0	-0.3	-1.0
Falls in the last year	2.6	3.5	6.5	0.6	1.3	-2.3	-2.5	-2.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.2	-0.2	-0.6	-0.6	-0.9
Number of live births	1.0	1.4	2.9	0.9	1.7	0.8	0.4	1.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.8	-1.0	-2.2	0.6	0.5	-0.2
Pulse rate	0.5	0.9	2.3	-1.5	0.3	-0.7	-1.0	-0.7
Happiness	2.4	2.9	4.8	-0.3	-1.8	2.2	2.2	1.2
Noisy workplace	0.1	0.2	0.3	0.1	0.6	-0.2	-0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	-0.8	0.3	0.2	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	9.2	1.5	3.0	-0.4	-1.1	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	2.7	-0.4	0.1	-0.7	-1.6	-0.7
Asthma	1.8	3.6	6.5	-1.5	-0.5	-2.5	-1.7	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	0.0	0.2	-0.4	-0.7	0.2
Medication: Cholesterol lowering	0.2	0.3	0.6	0.1	-0.2	0.7	0.8	0.7
Depression (self-reported)	0.6	0.7	1.4	-0.8	-0.0	-1.0	-0.5	-1.2
Medication: Lansoprazole	1.5	1.7	3.6	0.3	-1.0	1.9	1.4	1.2
Prospective memory result	0.2	0.2	0.6	-0.8	0.2	0.2	0.4	0.4
Lung cancer (father)	0.1	0.2	0.4	-0.6	-0.3	-0.2	0.5	-0.1
Illnesses of mother	0.2	0.3	1.2	1.1	-0.2	-0.3	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.5	-1.2	-1.2	-0.0	0.2	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.6	0.3	-0.7	-0.5	-0.8	-0.6
Impedance of arm (left)	0.5	2.1	7.0	2.6	0.9	-0.8	-1.4	-0.4
Arm fat mass (right)	0.5	2.2	6.5	-2.0	-2.5	-0.8	-0.2	-0.3
Trunk predicted mass	0.1	0.6	1.3	-1.2	-1.1	-0.4	0.5	0.1
Standing height	0.1	0.8	2.1	1.4	0.4	-1.0	-0.8	0.1
Length of working week for main job	0.6	0.7	1.2	-0.2	1.1	-1.0	-0.7	-0.9
Exposure to tobacco smoke at home	1.2	1.3	2.8	-0.3	0.3	-1.7	-1.5	-1.3
Breastfed as a baby	1.1	1.4	3.1	0.5	-0.7	-0.5	-1.8	-1.7
Tense / ‘highly strung’	0.1	0.2	0.4	-0.4	-0.1	-0.5	0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	0.4	-0.3	-0.9	-1.3	-1.1
Hair/balding pattern: Pattern 4	0.5	1.2	1.7	-1.3	0.9	1.1	1.2	1.1
Birth weight of first child	0.6	1.1	1.7	-1.2	-0.6	-1.2	-0.7	-1.3
Peak expiratory flow (PEF)	0.6	1.4	2.4	-0.3	-1.5	1.6	1.3	0.5
Pulse wave reflection index	1.1	1.4	2.8	-0.5	-1.7	0.9	1.5	0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	0.5	-1.2	0.4	0.3	-0.0
Loud music exposure frequency	0.5	0.6	1.9	-1.4	0.6	-0.7	0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.8	-0.6	1.0	-1.3	-1.2	-1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.8	-0.1	-0.5	-0.6	-0.4
Blood clot in the leg (DVT)	0.6	0.8	2.4	1.5	1.1	-0.1	0.2	0.6
Medication: Paracetamol	0.6	1.0	2.8	-1.4	-1.7	-0.3	-0.3	-0.4
Headache pain in last month	1.5	2.6	7.3	-2.7	-0.5	-1.7	-1.0	-1.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	0.7	1.1	-0.0	0.4	0.3
Glaucoma (self-reported)	0.4	0.5	1.5	0.4	0.6	-1.2	-0.5	-0.6
Gout (self-reported)	0.6	0.8	2.3	1.5	0.9	-0.0	-0.9	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.2	0.0	-0.2	-0.2	-0.2
Medication: Amlodipine	1.3	1.9	3.4	1.8	0.5	1.4	0.9	1.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.2	0.3	-0.6	0.0	-0.7
Birth weight	0.1	0.2	0.7	0.0	0.2	0.9	0.3	0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	1.1	1.0	0.4	-0.1	0.2
High blood pressure (siblings)	1.7	2.4	4.3	0.3	-0.8	-2.1	-2.0	-1.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	-1.0	-1.1	-0.6	-0.2	-0.7
Body fat percentage	0.6	2.4	8.0	-1.6	-2.8	-0.9	-0.7	-0.5
Leg fat percentage (right)	1.3	4.7	13.4	-2.4	-3.7	-1.4	-1.1	-1.0
Arm fat-free mass (right)	0.2	1.3	2.8	-1.7	-1.4	0.3	1.1	0.5
Exposure to tobacco smoke outside home	0.6	0.9	2.1	0.2	0.8	-1.4	-1.0	-0.7
Comparative body size at age 10	0.7	1.8	3.0	-0.9	-0.8	-1.5	-1.7	-1.6
Number of full brothers	0.6	0.7	2.4	-1.5	0.1	-0.6	-0.4	-0.9
Worry too long after embarrassment	0.1	0.1	0.3	0.2	0.1	0.2	-0.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	0.8	0.6	-1.2	-0.7	-1.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.2	0.4	-0.5	0.4	-0.1
Number of children fathered	0.3	0.3	0.7	0.7	0.5	0.4	-0.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.3	1.8	1.0	-0.8	-1.3	-0.7
Age at first live birth	1.2	2.1	3.9	0.8	0.1	-1.6	-1.9	-2.0
Pulse wave peak to peak time	0.4	0.4	0.7	-0.2	0.8	0.6	0.8	0.8
Health satisfaction	0.3	0.3	0.8	-0.9	-0.7	0.4	0.2	-0.5
Shortness of breath walking on level ground	1.0	1.2	2.2	-0.2	0.1	-1.3	-1.4	-1.5
Qualifications: College or University degree	0.4	1.2	2.8	-1.0	-0.5	-1.7	-0.9	-1.2
Eye problems/disorders: None of the above	0.5	0.6	1.0	0.6	0.3	1.0	0.7	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.4	0.8	-0.0	-0.4	-0.6
Emphysema/chronic bronchitis	0.4	0.5	1.2	1.1	0.7	-0.5	0.6	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	3.0	0.7	1.7	-0.4	-0.5	-0.8
Neck or shoulder pain in last month	0.2	0.3	0.7	0.3	0.8	-0.2	-0.6	-0.6
Medication: Blood pressure	0.9	1.6	4.0	-1.6	-2.0	-0.3	-0.9	-0.7
Angina (self-reported)	0.4	0.5	1.3	1.1	0.5	-0.2	-1.0	-0.4
Migraine (self-reported)	0.2	0.3	0.7	-0.9	0.2	0.6	0.5	0.1
Medication: Ibuprofen	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.4	0.1
Medication: Allopurinol	0.1	0.2	0.6	0.8	0.1	0.5	-0.3	0.1
Medication: Omeprazole	0.2	0.2	0.8	0.4	-0.9	0.3	0.2	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.6	-0.7	0.0	0.4	0.2
Mean time to correctly identify matches	0.9	1.7	3.0	1.1	0.2	1.4	1.4	1.7
Heart disease (mother)	0.8	1.0	3.1	-1.8	-0.3	0.8	0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.0	1.7	-0.3	0.7	0.6	0.3
Whole body fat mass	0.6	2.5	7.5	-1.8	-2.7	-1.0	-0.5	-0.5
Leg fat mass (right)	1.0	3.7	10.6	-2.5	-3.3	-1.0	-0.5	-0.6
Arm predicted mass (right)	0.3	1.3	3.3	-1.8	-1.3	0.3	1.1	0.7
Pulse rate, automated reading	0.7	2.4	5.0	-2.2	1.1	-1.5	-1.2	-1.4
Alcohol intake frequency.	0.0	0.1	0.2	-0.4	0.1	0.3	0.3	-0.2
Comparative height size at age 10	0.1	0.5	1.4	0.2	-0.9	-1.2	-0.4	-0.2
Number of full sisters	0.5	0.6	1.0	0.8	0.8	1.0	0.6	0.6
Suffer from ‘nerves’	0.9	1.4	6.0	-2.4	-0.0	0.7	0.8	0.1
Overall health rating	0.3	0.7	1.5	-0.6	-0.7	-1.2	-0.7	-0.7
Chest pain or discomfort	0.2	0.3	1.0	0.4	0.3	-1.0	-0.3	-0.4
Had major operations	0.5	0.6	1.5	0.6	-1.2	0.7	0.5	0.5
Age at last live birth	1.1	1.5	2.8	0.4	-0.2	-1.4	-1.7	-1.6
Family relationship satisfaction	2.4	3.0	6.5	-2.1	-2.6	0.9	1.5	0.9
Leg pain on walking	1.4	1.8	7.1	1.1	2.7	0.6	0.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.3	1.7	2.1	-1.1	-1.2	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.9	-0.2	-0.1	-1.0	-1.4	-0.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.1	-0.5	-1.8	0.2	0.2	0.6
Medication: Aspirin	0.6	0.8	2.3	-1.1	-1.5	-0.1	0.5	0.5
Supplements: Vitamin C	0.2	0.2	0.7	-0.1	-0.8	-0.5	-0.2	0.2
Knee pain experienced in last month	0.7	1.1	2.5	0.0	-0.7	-1.2	-1.6	-1.1
Hypertension (Self-reported)	0.7	1.9	4.9	-1.1	-2.2	-1.1	-1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.5	5.3	8.5	1.7	0.6	2.9	2.7	2.7
Illnesses of father: Heart disease	0.6	0.9	2.4	0.8	1.5	-0.2	-0.4	-1.1
Illnesses of siblings: Diabetes	1.0	1.2	2.2	1.5	-0.2	-0.9	-1.5	-0.9
Smoking status: Previous	0.6	0.9	2.8	-0.5	-1.7	-0.5	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.5	1.5	-1.1	-0.8	-0.5
Whole body fat-free mass	0.1	0.7	1.5	-1.2	-1.0	-0.1	0.8	0.4
Leg fat-free mass (right)	0.1	0.4	0.9	-0.7	-0.3	0.2	0.9	0.7
Arm fat percentage (left)	0.4	1.6	5.0	-1.4	-2.2	-0.7	-0.5	-0.6
Average weekly red wine intake	0.3	0.4	1.0	0.6	1.0	-0.7	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.6	-0.5	-1.1	-1.9	-1.4	-1.4
Mood swings	0.2	0.3	1.4	0.3	1.2	0.1	0.1	0.1
Loneliness, isolation	2.1	2.9	6.9	1.8	2.6	1.2	0.9	1.4
Long-standing illness, disability or infirmity	0.3	0.4	0.7	-0.8	-0.5	-0.3	-0.8	-0.5
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	0.9	0.5	-0.2	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.1	-0.8	0.1	-0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.4	0.6	1.5	-0.2	-0.4	0.0
Friendships satisfaction	0.8	1.0	1.9	-1.0	-0.8	1.1	1.4	0.7
Qualifications: nursing, teaching	1.8	2.8	5.8	0.5	1.5	-2.4	-1.8	-1.6
Commuting to job workplace: Walk	0.5	0.6	1.5	-0.3	0.1	1.0	1.2	0.6
Eye problems/disorders: Cataract	1.2	1.4	2.7	-0.7	0.2	-1.5	-1.2	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	6.9	2.1	2.6	-0.4	-1.7	-1.0
Medication for cholesterol	0.7	1.1	1.8	-0.9	-1.0	1.3	1.1	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.4	1.2	0.6	-0.3	0.2	-0.0
Back pain experienced in last month	1.4	2.0	6.4	-1.7	-2.5	-0.7	-0.5	-0.4
Mineral and other dietary supplements	0.8	1.0	1.7	-0.0	1.3	1.1	1.2	0.9
Breast cancer (self-reported)	1.2	1.4	3.0	-0.7	0.0	1.3	1.7	1.4
Asthma (self-reported)	1.6	3.2	5.7	-1.6	-0.6	-2.4	-1.5	-2.3
Osteoporosis (self-reported)	2.1	2.6	3.6	1.3	1.7	1.9	1.5	1.5
Osteoarthritis (self-reported)	1.3	1.6	3.4	-0.2	0.3	-1.4	-1.8	-1.6
Medication: Aspirin	0.8	1.0	2.7	-0.9	-1.6	0.3	0.8	0.9
Medication: Gliclazide	1.1	1.2	3.5	0.6	-0.3	1.9	1.1	1.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.4	-0.2
Smoking status: Current	0.2	0.3	1.2	0.2	-1.1	0.1	-0.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.8	-0.5	0.3	-0.3	-0.3
Whole body water mass	0.1	0.7	1.6	-1.3	-1.0	-0.1	0.8	0.3
Leg predicted mass (right)	0.1	0.3	0.7	-0.7	-0.4	0.2	0.9	0.5
Arm fat mass (left)	0.5	2.1	6.3	-1.8	-2.5	-0.8	-0.3	-0.5
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.3	0.1	0.0	0.0	0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.8	0.5	0.4	0.5	0.8
Miserableness	0.3	0.5	1.3	-1.2	-0.4	-0.3	-0.1	-0.8
Guilty feelings	0.5	0.7	1.4	0.7	1.2	0.9	0.7	0.7
Wears glasses or contact lenses	0.5	0.6	1.2	-0.9	-1.1	0.6	0.7	0.3
Ever taken oral contraceptive pill	1.1	1.2	4.2	2.0	1.2	0.4	-0.6	-0.0
Hearing aid user	1.0	1.1	3.0	-1.7	-1.0	-0.3	-0.6	-1.1
Mother’s age at death	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.0	-0.3
Financial situation satisfaction	0.1	0.2	0.4	-0.6	-0.4	-0.5	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.8	0.1	0.2	1.7	1.2	1.5
Commuting to job workplace: Public transport	1.0	1.2	1.9	0.6	0.8	-1.2	-1.4	-1.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	-0.1	-0.2	-0.9	-0.4	-0.4
Medication: Blood pressure	0.1	0.2	0.6	-0.2	-0.3	-0.8	-0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.0	0.2	0.1	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.5	0.3	-0.0	-1.5	-1.6	-1.1
High cholesterol (Self-reported)	0.1	0.2	0.4	0.6	-0.0	0.5	0.4	0.4
Medication: Bendroflumethiazide	0.5	0.7	1.6	0.1	-0.0	1.3	1.0	1.0
Medication: Paracetamol	0.7	1.0	2.6	-1.5	-1.6	0.1	-0.2	-0.3
Medication: Lisinopril	1.9	2.4	7.9	-2.0	-2.8	0.2	0.2	-0.4
Medication: Atorvastatin	1.2	1.4	2.9	-0.0	-1.2	1.1	1.3	1.7
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.1	-0.2	0.5	0.2	-0.4
Alcohol drinker status: Never	0.7	0.9	1.5	0.4	0.8	-1.1	-1.2	-0.9
Ever smoked	0.2	0.3	0.9	1.0	0.0	0.2	-0.7	0.1
Basal metabolic rate	0.1	0.8	1.9	-1.4	-1.3	-0.3	0.5	0.2
Leg fat percentage (left)	0.9	3.2	10.4	-2.0	-3.2	-0.9	-0.7	-0.5
Arm fat-free mass (left)	0.2	1.0	2.4	-1.5	-1.6	-0.3	0.5	0.1
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1	-0.1
Average weekly beer plus cider intake	0.3	0.4	0.9	0.9	0.0	0.9	0.3	0.4
Irritability	0.2	0.4	1.0	-0.3	-0.3	-0.6	-0.6	-1.0
Risk taking	0.1	0.2	0.3	-0.5	0.2	-0.4	-0.6	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.4	0.1	-0.5	-0.8	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	1.3	1.2	0.4	-0.0	-0.0	-0.2
Age started oral contraceptive pill	0.7	0.9	2.9	0.9	-1.7	0.4	0.4	0.8
Diastolic blood pressure, automated reading	1.0	3.2	10.5	-1.2	-3.2	-1.2	-1.3	-0.9
Ever depressed for a whole week	0.4	0.5	1.5	-0.0	-0.4	-0.4	-0.9	-1.2
Unable to work because of sickness or disability	0.1	0.1	0.3	0.5	0.4	0.4	0.1	-0.2
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.7	-1.0	-0.5	-0.3	-0.9
Myopia	0.5	0.7	2.6	-0.5	-0.5	0.5	1.6	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.6	1.2	2.1	1.1	1.1	1.0
Cholesterol lowering medication	0.8	1.2	2.2	0.4	0.2	-1.3	-1.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	0.7	-0.7	1.3	0.7	0.5
Pain experienced in last month	0.2	0.3	0.7	-0.1	-0.2	0.8	0.7	0.5
Supplements: Calcium	0.9	1.0	2.2	-0.1	-1.0	1.5	1.0	0.9
Basal cell carcinoma (self-reported)	3.0	3.6	7.4	-1.0	-0.6	-2.7	-1.8	-2.5
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.1	-1.5	-2.3	1.0	1.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.0	1.4	1.1	-0.0	0.3	0.5
Heart disease (siblings)	0.5	0.7	1.2	1.0	-0.1	0.9	0.5	1.1
Alcohol drinker status: Previous	0.5	0.6	1.8	-0.5	-1.4	0.5	-0.0	-0.8
Pack years of smoking	0.4	0.6	1.2	-0.4	-1.1	-0.9	-0.6	-0.5
Impedance of whole body	0.4	2.0	4.3	2.1	0.7	-1.1	-1.8	-0.8
Leg fat mass (left)	0.7	2.7	8.2	-2.1	-2.9	-0.7	-0.2	-0.2
Arm predicted mass (left)	0.2	1.1	2.8	-1.7	-1.5	-0.2	0.6	0.0