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chr11:64,845,438-66,919,278

Best TWAS P=1.97e-15 · Best GWAS P=5.61e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EIF1AD	0.11	0.15	enet	14	0.14	2.9e-06	-7.8	-7.9	2.0e-15	0.98	0.00	0.99	TRUE
18	GTEx	Lung	CFL1	0.04	0.02	lasso	10	0.01	5.8e-02	-7.4	7.9	2.1e-15	-0.90	0.05	0.87	FALSE
12	GTEx	Cells Transformed fibroblasts	EIF1AD	0.28	0.20	lasso	8	0.21	1.8e-15	-7.4	-7.9	3.5e-15	0.93	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BANF1	0.03	0.04	lasso	4	0.03	1.4e-04	-7.8	7.8	9.0e-15	-0.99	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	EIF1AD	0.05	0.06	blup	42	0.02	1.3e-02	-7.4	-7.7	1.4e-14	0.98	0.01	0.95	FALSE
15	GTEx	Esophagus Mucosa	EIF1AD	0.15	0.12	lasso	4	0.10	3.2e-07	-7.7	-7.7	1.5e-14	0.98	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF1AD	0.06	0.04	lasso	3	0.05	1.3e-03	-7.2	-7.6	3.2e-14	0.97	0.01	0.98	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	EIF1AD	0.08	0.10	enet	3	0.09	6.0e-10	-7.8	-7.6	3.2e-14	1.00	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF1AD	0.07	0.07	enet	5	0.05	1.5e-03	-7.4	-7.5	4.3e-14	0.95	0.01	0.97	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF1AD	0.09	0.06	blup	42	0.07	3.2e-06	-7.8	-7.5	6.6e-14	0.93	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	BANF1	0.13	0.05	lasso	8	0.07	1.0e-06	-7.2	7.3	2.4e-13	-0.87	0.09	0.91	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EIF1AD	0.03	0.02	blup	42	0.02	1.5e-03	-7.4	-7.3	2.7e-13	0.92	0.02	0.94	FALSE
22	GTEx	Spleen	CTD-3074O7.5	0.29	0.03	enet	27	0.05	2.6e-02	1.7	-7.3	3.2e-13	0.60	0.03	0.42	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF1AD	0.02	0.03	blup	42	0.03	4.3e-07	-7.3	-7.1	1.1e-12	0.94	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DRAP1	0.09	0.10	enet	12	0.09	1.8e-04	-7.8	7.1	1.1e-12	-0.94	0.00	0.94	FALSE
7	GTEx	Artery Tibial	BANF1	0.05	0.05	lasso	5	0.06	3.4e-05	-6.2	7.0	2.3e-12	-0.83	0.06	0.88	FALSE
23	GTEx	Thyroid	BANF1	0.10	0.05	enet	17	0.06	4.5e-05	-7.3	6.9	5.1e-12	-0.93	0.04	0.96	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf68	0.03	0.03	lasso	3	0.03	1.1e-04	-6.8	6.8	7.5e-12	-0.86	0.05	0.57	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EIF1AD	0.10	0.09	enet	6	0.08	9.5e-05	-7.8	-6.8	9.3e-12	0.93	0.00	0.98	FALSE
21	GTEx	Skin Sun Exposed Lower leg	EIF1AD	0.08	0.07	lasso	4	0.07	3.6e-06	5.2	-6.8	1.1e-11	0.86	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	BANF1	0.06	0.02	blup	44	0.04	1.7e-05	-7.3	6.7	1.8e-11	-0.71	0.01	0.90	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TSGA10IP	0.19	0.01	lasso	5	0.02	2.2e-02	-7.3	6.7	2.5e-11	-0.85	0.01	0.83	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	EFEMP2	0.08	0.09	enet	13	0.09	6.8e-12	5.9	-6.7	2.8e-11	0.78	0.84	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EIF1AD	0.09	0.05	enet	13	0.06	2.7e-08	3.6	-6.6	3.2e-11	0.63	0.34	0.66	FALSE
25	METSIM	Adipose	EFEMP2	0.07	0.05	lasso	8	0.04	4.2e-06	-6.2	-6.5	8.3e-11	0.78	0.11	0.89	FALSE
5	GTEx	Artery Aorta	SART1	0.08	0.00	enet	23	0.00	2.1e-01	-6.8	6.5	9.3e-11	-0.79	0.04	0.57	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CFL1	0.04	0.00	bslmm	350	0.02	3.3e-03	-2.2	6.4	1.3e-10	-0.70	0.05	0.58	FALSE
17	GTEx	Heart Atrial Appendage	EIF1AD	0.09	0.01	enet	25	0.01	1.7e-01	2.0	-6.3	3.0e-10	0.50	0.06	0.13	FALSE
31	YFS	Blood	EFEMP2	0.12	0.07	bslmm	348	0.13	4.3e-41	-6.2	-6.3	3.5e-10	0.45	1.00	0.00	FALSE
27	NTR	Blood	BANF1	0.03	0.00	enet	10	0.02	1.1e-06	5.2	6.2	4.8e-10	-0.57	0.14	0.30	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	FIBP	0.03	0.03	blup	45	0.03	2.6e-07	-6.3	-6.2	5.4e-10	0.73	0.09	0.91	FALSE
13	GTEx	Colon Sigmoid	CTSW	0.11	0.06	lasso	3	0.07	1.4e-03	-6.4	6.2	6.1e-10	-0.69	0.10	0.61	FALSE
19	GTEx	Lung	BANF1	0.11	0.03	lasso	6	0.07	6.5e-06	5.2	6.1	8.0e-10	-0.76	0.30	0.68	FALSE
30	YFS	Blood	BANF1	0.14	0.19	bslmm	342	0.21	8.3e-67	-7.2	6.1	8.5e-10	-0.85	0.17	0.83	FALSE
10	GTEx	Cells Transformed fibroblasts	CFL1	0.06	0.02	enet	12	0.01	1.1e-01	-6.6	6.0	1.8e-09	-0.53	0.40	0.16	FALSE
6	GTEx	Artery Tibial	EFEMP2	0.11	0.07	lasso	8	0.05	1.3e-04	5.2	-6.0	2.5e-09	0.71	0.31	0.67	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	BANF1	0.05	0.02	blup	325	0.03	2.4e-04	-7.8	5.9	3.3e-09	-0.74	0.01	0.98	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	TSGA10IP	0.04	0.01	blup	44	0.02	1.1e-02	5.2	5.9	4.0e-09	-0.78	0.01	0.51	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BANF1	0.08	0.07	lasso	4	0.06	1.8e-03	5.4	5.8	5.3e-09	-0.69	0.02	0.69	FALSE
16	GTEx	Esophagus Muscularis	FIBP	0.11	0.04	lasso	4	0.04	1.2e-03	-6.6	-5.7	1.4e-08	0.53	0.62	0.12	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	-6.3	-5.7	1.5e-08	0.73	0.14	0.84	FALSE
32	YFS	Blood	MUS81	0.04	0.02	blup	348	0.04	6.3e-12	-6.4	5.6	2.3e-08	-0.67	0.92	0.08	FALSE
14	GTEx	Esophagus Mucosa	BANF1	0.19	0.10	enet	17	0.15	1.8e-10	-7.4	5.5	2.9e-08	-0.70	0.08	0.92	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX32	0.13	0.05	blup	60	0.09	1.1e-03	-2.7	-5.5	3.6e-08	0.63	0.03	0.79	FALSE
26	METSIM	Adipose	SART1	0.08	0.05	enet	26	0.05	1.1e-07	-7.3	5.5	3.9e-08	-0.76	0.05	0.95	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF1AD	0.03	0.00	blup	42	0.01	2.5e-02	-0.3	-5.5	4.2e-08	0.82	0.01	0.49	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	CATSPER1	0.03	0.01	blup	41	0.02	3.4e-03	-7.3	5.4	5.7e-08	-0.78	0.01	0.81	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFEMP2	0.01	0.00	blup	45	0.01	3.0e-02	-5.0	-5.4	6.1e-08	0.63	0.02	0.47	FALSE
9	GTEx	Brain Cerebellum	EFEMP2	0.45	0.40	enet	8	0.39	1.6e-12	-6.4	-5.4	7.0e-08	0.66	0.98	0.02	FALSE
11	GTEx	Cells Transformed fibroblasts	BANF1	0.24	0.08	enet	20	0.12	4.6e-09	-7.2	5.4	7.9e-08	-0.74	0.08	0.92	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	EIF1AD	0.14	0.12	lasso	3	0.10	2.8e-06	5.2	-5.3	8.6e-08	0.69	0.12	0.86	FALSE
24	GTEx	Whole Blood	CTSW	0.08	0.01	enet	11	0.04	5.4e-05	-2.7	5.3	1.2e-07	-0.65	0.77	0.15	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FIBP	0.04	0.02	blup	45	0.04	4.0e-05	-2.7	-5.3	1.2e-07	0.53	0.33	0.42	FALSE
8	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	-6.2	-5.2	1.8e-07	0.66	0.28	0.24	FALSE
4	GTEx	Adrenal Gland	AP001266.1	0.15	0.00	enet	2	0.00	4.1e-01	5.2	-5.2	2.2e-07	0.67	0.05	0.09	FALSE