TWAS hub - CATSPER1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0158	0.008	0.0036	0.010	0.009	0.008	NA	0.006	0.00018	0.00055	0.00076	NA	0.0043
2	TCGA	Thyroid Carcinoma	0.0320	0.019	0.0033	0.012	0.021	0.013	NA	0.016	0.02200	0.00340	0.01900	NA	0.0100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Comparative body size at age 10	8.0	22.0	24.6	-5.0	-4.4
Forced vital capacity (FVC)	7.9	30.5	44.2	6.7	4.1
Lung FVC	7.3	37.2	49.4	7.0	5.0
Forced vital capacity (FVC), Best measure	6.8	24.7	33.2	5.8	4.0
Blood Eosinophil Count	6.7	51.9	67.2	6.0	8.2
Forced expiratory volume in 1-second (FEV1)	6.7	22.4	34.0	5.8	3.3
LDL Cholesterol	6.5	10.3	15.7	-4.0	-2.2
Hayfever/allergic rhinitis (self-reported)	6.3	8.4	13.3	1.9	3.6
Peak expiratory flow (PEF)	6.0	14.0	23.5	4.8	2.1
Gout (self-reported)	5.7	7.8	11.2	3.4	2.1
Medication: Allopurinol	5.5	7.3	11.1	3.3	1.9
Waist Hip Ratio (WHR)	5.1	23.0	28.2	4.2	5.3
Forced expiratory volume in 1-second (FEV1), Best measure	5.1	16.1	22.8	4.8	3.1
Birth weight	5.0	11.0	15.8	-4.0	-2.5
Illness, injury, bereavement, stress in last 2 years	4.6	5.7	10.1	-1.1	-3.2
Mineral and other dietary supplements	4.5	6.1	8.6	-2.9	-1.9
Allergy or Eczema	4.2	11.2	15.9	2.5	4.0
Medication: Amlodipine	4.2	5.9	10.1	3.2	1.3
Hand grip strength (left)	4.1	10.7	12.6	3.5	3.0
Standing height	4.0	39.7	57.8	7.6	4.7
Alcohol drinker status: Never	4.0	4.8	4.8	-2.2	-2.2
Health satisfaction	3.9	5.0	9.4	-3.1	-0.8
Ever highly irritable/argumentative for 2 days	3.8	4.6	4.7	-2.2	-2.1
Comparative height size at age 10	3.7	20.1	27.5	5.2	3.6
Ever taken oral contraceptive pill	3.6	4.0	4.3	1.9	2.1
Medication: Atenolol	3.4	4.3	6.5	2.6	1.4
Migraine (self-reported)	3.4	4.2	7.6	-2.8	-0.9
Friendships satisfaction	3.4	4.2	4.2	-2.1	-2.0
Ulcerative Colitis (UC)	3.3	6.3	7.5	-2.3	-2.7
Height	3.3	64.4	102.0	10.1	5.2
Stomach or abdominal pain in last month	3.1	3.8	4.7	-1.7	-2.2
Hayfever, allergic rhinitis or eczema	3.0	6.5	10.3	1.6	3.2
Irritable Bowel Disease (IBD)	2.9	6.8	8.2	-2.3	-2.9
Hypothyroidism (self reported)	2.9	6.7	8.5	2.2	2.9
Relative age of first facial hair	2.9	5.9	9.5	-3.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	8.6	-2.9	-0.6
Townsend deprivation index at recruitment	2.8	4.0	4.5	2.1	1.9
Lung cancer (father)	2.8	3.3	4.4	-2.1	-1.5
Lupus	2.7	4.1	4.3	2.0	2.1
Blood White Count	2.7	20.2	29.5	3.3	5.4
Alcohol intake versus 10 years previously	2.7	4.1	5.3	1.7	2.3
Medication: Gliclazide	2.7	3.1	3.7	-1.6	-1.9
Eye problems/disorders: Glaucoma	2.7	3.1	3.5	1.9	1.7
Alcohol usually taken with meals	2.6	4.2	5.4	2.3	1.7
Breast Cancer	2.5	6.1	6.1	2.5	2.5
Family relationship satisfaction	2.5	3.1	4.7	-2.2	-1.2
Number of operations (self-reported)	2.5	3.7	6.0	-2.5	-1.2
Supplements: Calcium	2.5	2.7	2.8	1.6	1.7
Supplements: Glucosamine	2.4	3.1	3.8	2.0	1.5
Medication: Blood pressure	2.4	4.6	5.1	2.3	2.0
Risk taking	2.4	3.5	4.0	2.0	1.7
Prostate Cancer	2.3	3.2	4.7	-2.2	-1.3
Hearing difficulty/problems: Yes	2.3	3.5	4.3	-2.1	-1.6
Number of full sisters	2.3	2.8	4.4	1.1	2.1
Osteoarthritis (self-reported)	2.3	3.0	3.1	1.7	1.8
Rheumatoid Arthritis	2.1	2.9	4.0	2.0	1.3
Medication: Co-codamol	2.1	2.5	4.0	-2.0	-1.0
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	3.2	1.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	4.4	2.1	2.1
Ulcerative Colitis	2.0	2.9	3.0	-1.6	-1.7
Hand grip strength (right)	2.0	5.3	6.9	2.6	1.9
Body mass index (BMI)	2.0	8.4	11.4	-3.4	-2.3
Arm fat percentage (right)	2.0	7.8	12.5	-3.5	-1.8
Supplements: Fish oil (including cod liver oil)	2.0	2.7	5.3	2.3	0.2
Major Depression (MDD)	1.9	2.3	3.5	1.1	1.9
Crohns Disease (2012)	1.9	3.1	5.4	-0.9	-2.3
Allergy	1.9	4.3	8.1	-0.7	-2.8
Shortness of breath walking on level ground	1.9	2.2	4.2	-2.1	-0.5
Basal cell carcinoma (self-reported)	1.9	2.2	3.2	-1.8	-1.1
BMI	1.8	10.3	14.3	-3.8	-2.5
Multivitamins +/- minerals	1.8	2.2	2.9	1.7	1.3
Hypothyroidism/myxoedema (self-reported)	1.8	3.4	4.7	1.5	2.2
Arm fat percentage (left)	1.8	7.1	10.8	-3.3	-1.8
Asthma (self-reported)	1.8	3.6	7.2	-2.7	-0.1
Medication: Lisinopril	1.8	2.3	4.3	2.1	0.6
Diastolic blood pressure, automated reading	1.8	5.7	10.2	3.2	1.1
Neuroticism (2016)	1.7	2.4	4.0	-0.9	-2.0
Angina	1.7	2.2	3.7	1.9	0.8
Medication: Levothyroxine sodium	1.7	3.0	4.7	1.1	2.2
Falls in the last year	1.7	2.4	2.7	1.4	1.6
Asthma	1.7	3.4	6.9	-2.6	0.1
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.0	-2.0	-0.6
Heart disease (mother)	1.7	2.1	2.5	1.3	1.6
Overall health rating	1.7	3.6	6.7	-2.6	-0.7
Qualifications: nursing, teaching	1.7	2.7	3.2	1.8	1.5
Average weekly champagne plus white wine intake	1.7	2.3	2.4	1.6	1.5
Alzheimer’s Disease (in mother)	1.6	1.9	2.8	1.0	1.7
Crohns Disease (2017)	1.6	3.4	4.5	-1.5	-2.1
Pack years adult smoking proportion	1.6	2.5	4.4	0.7	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	4.2	2.1	1.7
Worry too long after embarrassment	1.6	2.6	3.6	-1.9	-1.3
Supplements: Vitamin C	1.6	1.9	2.0	1.3	1.4
Diabetes (self-reported)	1.5	2.3	4.5	-2.1	-0.2
Angina (self-reported)	1.5	1.9	3.3	1.8	0.7
Age started oral contraceptive pill	1.5	1.8	2.1	-1.5	-1.2
Pack years of smoking	1.5	2.3	3.8	0.8	2.0
Hearing difficulty/problems with background noise	1.4	2.2	2.6	-1.6	-1.3
Pulse rate	1.4	2.4	3.0	-1.7	-1.3
Average weekly red wine intake	1.4	2.0	2.4	1.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.2	1.1	1.5
Wears glasses or contact lenses	1.4	1.6	2.5	-1.6	-0.9
Impedance of leg (right)	1.3	6.5	8.4	2.9	2.1
Diabetes diagnosed by doctor	1.3	2.1	4.1	-2.0	-0.1
Hearing aid user	1.3	1.4	1.9	-1.4	-0.9
Bipolar Disorder (2011)	1.2	1.2	1.8	0.7	1.3
Ever had hysterectomy (womb removed)	1.2	1.4	2.2	-0.7	-1.5
Medication: Metformin	1.2	1.7	3.0	-1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	3.0	1.7	1.6
Number of incorrect matches in round	1.2	2.1	4.1	-0.2	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	1.9	1.4	1.1
Age at first live birth	1.2	2.1	3.5	1.9	0.8
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.2	0.8	1.5
Pulse rate, automated reading	1.2	3.9	4.5	-1.9	-2.1
Alzheimer’s Disease (including proxy)	1.1	1.6	2.5	0.8	1.6
Coronary Artery Disease (CAD)	1.1	1.3	2.4	1.6	0.3
Impedance of leg (left)	1.1	5.2	7.6	2.7	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	3.2	-1.8	-0.4
Noisy workplace	1.1	1.4	1.5	-1.2	-1.1
Impedance of arm (left)	1.1	4.9	5.8	2.4	2.0
Exposure to tobacco smoke at home	1.1	1.2	2.0	-1.4	-0.7
Glaucoma (self-reported)	1.1	1.3	1.6	1.3	1.0
Leg fat percentage (right)	1.1	3.9	6.2	-2.5	-1.3
Mean time to correctly identify matches	1.1	2.1	4.1	-2.0	-0.0
Leg fat percentage (left)	1.1	4.0	5.9	-2.4	-1.4
Age at First Birth	1.0	1.5	2.5	0.7	1.6
Diabetes (mother)	1.0	1.3	1.5	1.1	1.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.2	-1.5	-0.3
Body fat percentage	1.0	3.8	5.3	-2.3	-1.5
Number of full brothers	1.0	1.3	1.3	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.8	-1.3	-0.8
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.6	-1.3	-0.8
Mean Putamen Volume	0.9	1.0	1.5	-0.8	-1.2
Blood Red Count	0.9	8.4	8.8	-2.8	-3.0
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.7	-1.3	-0.9
Financial difficulties in last 2 years	0.9	1.1	2.2	-0.3	1.5
Impedance of arm (right)	0.9	4.2	4.3	2.0	2.1
Trunk fat-free mass	0.9	5.1	7.7	2.8	1.6
Arm fat mass (right)	0.9	3.5	5.2	-2.3	-1.4
Trunk predicted mass	0.9	5.0	7.7	2.8	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.5	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.6	1.6	1.1
Cholesterol lowering medication	0.9	1.3	2.5	-1.6	-0.1
Vitamin and mineral supplements	0.8	1.1	1.4	-1.2	-0.9
Relative age voice broke	0.8	1.2	1.7	-1.3	-0.9
Serious illness, injury or assault to yourself	0.8	0.9	1.9	-1.4	-0.0
Mouth/teeth dental problems	0.8	1.2	2.4	1.6	0.2
Prospective memory result	0.8	1.0	2.0	-0.3	-1.4
Length of working week for main job	0.8	0.8	1.0	-1.0	-0.8
Medication: Omeprazole	0.8	1.0	1.4	-1.2	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	1.8	-0.1	1.3
Leg fat mass (right)	0.8	3.0	4.0	-2.0	-1.4
Age at last live birth	0.8	1.1	1.4	1.2	0.9
Ever had bowel cancer screening	0.8	0.9	1.0	-1.0	-0.9
Commuting to job workplace: Walk	0.8	0.9	1.3	-1.1	-0.7
Medication: Aspirin	0.8	1.0	2.0	0.1	-1.4
Illnesses of father: None of the above (group 1)	0.8	0.9	1.2	-0.9	-1.1
Arm fat mass (left)	0.8	3.1	4.5	-2.1	-1.3
High cholesterol (Self-reported)	0.8	1.4	2.7	-1.6	-0.2
Pain experienced in last month	0.8	1.3	2.5	1.6	0.1
Bipolar Disorder (2018)	0.7	1.0	1.8	-0.5	1.3
Bipolar Disorder or Schizophrenia	0.7	1.7	3.2	-0.5	1.8
Heel T-Score	0.7	5.3	7.4	2.7	1.8
Systolic Blood Pressure	0.7	3.5	6.8	2.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	-1.4	0.0
High blood pressure (mother)	0.7	0.9	1.4	1.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.9	-1.4	-0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.1	-0.8	1.0
Qualifications: College or University degree	0.7	2.3	4.2	2.0	0.7
Back pain experienced in last month	0.7	1.1	1.5	0.8	1.2
Medication: Atorvastatin	0.7	0.9	1.4	1.2	0.6
Impedance of whole body	0.7	3.7	4.5	2.1	1.7
Leg fat mass (left)	0.7	2.7	3.5	-1.9	-1.4
Primary Biliary Cirrhosis	0.6	0.9	1.5	-1.2	-0.5
Lung FEV1/FVC ratio	0.6	3.2	5.2	-1.1	-2.3
Diabetes (father)	0.6	0.7	1.3	0.5	1.1
Average weekly fortified wine intake	0.6	0.7	1.0	-0.7	-1.0
Taking other prescription medications	0.6	0.9	1.4	-1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-1.0	-0.6
Heart attack	0.6	0.8	1.1	1.0	-0.6
Hair/balding pattern: Pattern 3	0.6	1.0	1.4	-1.2	-0.7
Depression (self-reported)	0.6	0.7	0.8	-0.8	0.9
Neck or shoulder pain in last month	0.6	0.9	1.0	-0.9	-1.0
Medication: Blood pressure	0.6	1.1	2.0	0.4	-1.4
Illnesses of father: Heart disease	0.6	0.8	1.1	0.7	1.0
Financial situation satisfaction	0.6	0.8	1.5	-1.2	-0.2
Medication: Bendroflumethiazide	0.6	0.9	1.8	-0.1	-1.3
Ever smoked	0.6	1.1	1.4	0.9	1.2
Average weekly beer plus cider intake	0.6	0.9	1.7	-0.0	1.3
Commuting to job workplace: Cycle	0.6	0.7	1.5	1.2	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	1.1	-0.7
Respiratory disease	0.5	1.1	1.7	-1.3	0.7
Severe depression (siblings)	0.5	0.6	0.7	0.7	0.8
Trunk fat percentage	0.5	1.9	2.3	-1.5	-1.2
Sitting height	0.5	3.2	6.3	2.5	-0.3
Medication: Simvastatin	0.5	0.7	1.3	-1.1	0.5
Suffer from ‘nerves’	0.5	0.8	1.4	0.5	1.2
Whole body fat-free mass	0.5	2.8	4.7	2.2	1.0
Medication for cholesterol	0.5	0.8	0.8	-0.9	-0.9
Breast cancer (self-reported)	0.5	0.6	1.3	-0.0	-1.1
Whole body water mass	0.5	2.7	4.4	2.1	1.0
Number of self-reported non-cancer illnesses	0.5	0.9	1.1	-0.8	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.0	1.0	0.6
Medication: Paracetamol	0.5	0.8	0.9	-1.0	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.8	-0.9	-0.5
Ever depressed for a whole week	0.5	0.6	1.2	-1.1	-0.0
Schizophrenia (2018)	0.4	0.7	1.5	-0.2	1.2
Reaction Time	0.4	0.8	1.2	-1.1	0.7
Schizophrenia (2014)	0.4	0.8	1.6	-0.0	1.3
Average weekly spirits intake	0.4	0.5	0.6	-0.6	-0.8
Sensitivity / hurt feelings	0.4	0.7	1.3	-0.4	-1.1
Maternal smoking around birth	0.4	0.6	1.0	-0.4	-1.0
Fed-up feelings	0.4	0.7	1.1	-1.1	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	0.8	-0.9	-0.3
Wheeze or whistling in the chest in last year	0.4	0.8	1.5	-1.2	-0.1
Pulse wave peak to peak time	0.4	0.5	0.5	0.6	0.7
Medication: Ibuprofen	0.4	0.4	0.6	0.8	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	-0.9	-0.4
Medication: Aspirin	0.4	0.5	1.0	0.1	-1.0
Long-standing illness, disability or infirmity	0.4	0.6	1.0	-1.0	-0.4
Guilty feelings	0.4	0.6	0.8	-0.6	-0.9
Unable to work because of sickness or disability	0.4	0.5	0.9	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.0	-1.4	-0.6
Heart disease (siblings)	0.4	0.5	0.9	-0.5	0.9
Neuroticism (Nagel 2018)	0.3	0.8	1.4	-1.2	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	0.4	-0.6	-0.6
HbA1C	0.3	0.3	0.5	-0.4	-0.7
Blood Platelet Count	0.3	3.2	5.0	2.2	1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.7	-0.9	0.6
Neuroticism	0.3	0.8	1.4	-1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.9	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.5	0.8
Nervous feelings	0.3	0.5	0.6	0.6	0.8
Worrier / anxious feelings	0.3	0.6	1.2	-1.1	-0.1
Number of live births	0.3	0.4	0.8	0.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.7	-0.8	-0.4
Headache pain in last month	0.3	0.5	1.0	-0.0	1.0
Arm fat-free mass (right)	0.3	1.7	3.0	1.7	0.7
Whole body fat mass	0.3	1.2	1.5	-1.2	-0.9
Arm predicted mass (right)	0.3	1.7	3.0	1.7	0.7
Had major operations	0.3	0.4	0.7	-0.3	-0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.4	0.6	0.6
Hypertension (Self-reported)	0.3	0.8	1.6	1.3	0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.2	0.8
Osteoporosis (self-reported)	0.3	0.3	0.5	0.4	0.7
Miserableness	0.3	0.5	0.9	0.4	0.9
Illnesses of father: High blood pressure	0.3	0.4	0.4	0.6	0.7
Basal metabolic rate	0.3	1.8	2.9	1.7	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.0	0.4	-1.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.5	-0.5
Hair Pigment	0.2	4.4	6.9	-1.4	-2.6
Systolic blood pressure, automated reading	0.2	0.7	1.4	1.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	0.4	-0.5
Leg fat-free mass (left)	0.2	0.8	1.4	1.2	0.6
Current tobacco smoking	0.2	0.3	0.4	-0.5	0.6
Leg predicted mass (left)	0.2	0.8	1.4	1.2	0.5
Medication: Ramipril	0.2	0.2	0.3	0.3	-0.6
Fluid intelligence score	0.2	0.4	0.6	0.5	-0.8
Hip circumference	0.2	0.9	1.8	-0.1	-1.3
Illnesses of mother	0.2	0.2	0.2	-0.4	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.8	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	-0.2
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.6	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.2	0.4	0.5
Smoking status: Previous	0.2	0.3	0.5	-0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.1	0.6
Mood swings	0.2	0.4	0.7	-0.8	-0.2
Loneliness, isolation	0.2	0.2	0.3	-0.4	0.5
Smoking status: Current	0.2	0.2	0.3	-0.6	0.4
Arm fat-free mass (left)	0.2	1.0	1.7	1.3	0.5
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.1	0.7
Myopia	0.2	0.2	0.5	0.7	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.5	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	0.1	0.6
Arm predicted mass (left)	0.2	0.8	1.4	1.2	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	0.0
Worry (Nagel 2018)	0.1	0.2	0.3	-0.4	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	-0.4
Ovarian Cancer	0.1	0.2	0.2	0.4	0.4
Fasting Glucose	0.1	0.1	0.2	0.4	0.0
HDL Cholesterol	0.1	0.2	0.4	0.0	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.4	-0.1
Smoking Status	0.1	0.2	0.3	0.6	0.3
Cardiovascular Disease	0.1	0.5	0.7	0.8	0.6
Chronotype (morning person)	0.1	0.3	0.6	0.8	0.3
Number of treatments/medications taken	0.1	0.2	0.4	-0.6	0.0
Medication for hormone replacement therapy	0.1	0.1	0.3	0.5	0.0
Supplements: Zinc	0.1	0.1	0.1	-0.1	0.3
High blood pressure	0.1	0.4	0.7	0.8	0.2
Trunk fat mass	0.1	0.5	0.5	-0.7	-0.7
Waist circumference	0.1	0.4	0.6	0.3	0.8
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.1
Neuroticism score	0.1	0.3	0.4	-0.7	-0.3
Time employed in main current job	0.1	0.1	0.3	-0.2	0.5
Happiness	0.1	0.1	0.2	-0.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.1	0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.4	0.1
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	0.4
Breastfed as a baby	0.1	0.1	0.2	-0.4	0.3
Tense / ‘highly strung’	0.1	0.2	0.3	0.2	0.6
Birth weight of first child	0.1	0.1	0.2	-0.4	-0.3
Loud music exposure frequency	0.1	0.2	0.2	0.3	0.4
Medication: Paracetamol	0.1	0.2	0.2	-0.5	-0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.5	0.4
Chest pain or discomfort	0.1	0.1	0.2	0.2	0.4
Leg pain on walking	0.1	0.1	0.2	-0.1	0.5
Knee pain experienced in last month	0.1	0.2	0.3	-0.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	0.2
Leg fat-free mass (right)	0.1	0.7	1.4	1.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	-0.2
Eye problems/disorders: Cataract	0.1	0.2	0.3	0.5	-0.2
Leg predicted mass (right)	0.1	0.6	1.2	1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.6	0.1
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.4	0.1
Depression (Nagel 2018)	0.0	0.0	0.1	-0.1	0.3
Triglycerides	0.0	0.1	0.1	-0.2	-0.3
Tanning	0.0	0.6	0.6	-0.8	0.8
Age when periods started (menarche)	0.0	0.1	0.1	-0.3	0.4
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	0.0
Past tobacco smoking	0.0	0.0	0.0	-0.1	-0.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.1	0.1
Had menopause	0.0	0.0	0.0	-0.1	-0.1
Had other major operations	0.0	0.0	0.0	0.2	0.1
Qualifications: None of the above	0.0	0.1	0.1	0.2	0.3
Illnesses of siblings	0.0	0.0	0.0	0.1	-0.1
Weight	0.0	0.0	0.0	0.1	-0.2
Father’s age at death	0.0	0.0	0.0	-0.1	-0.0
Medication: Cholesterol lowering	0.0	0.1	0.1	0.1	0.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.0	-0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.0
Pulse wave reflection index	0.0	0.0	0.0	0.0	0.0
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	0.2
High blood pressure (siblings)	0.0	0.0	0.1	0.2	-0.2
Number of children fathered	0.0	0.0	0.1	0.2	0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.4	-0.1
Alcohol intake frequency.	0.0	0.0	0.1	0.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.3	0.1
Mother’s age at death	0.0	0.0	0.0	-0.2	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.1	0.2
Irritability	0.0	0.0	0.1	-0.0	-0.2

Hub : Genes

CATSPER1

Models

Trait associations