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chr11:59,239,839-62,605,067

Best TWAS P=9.23e-24 · Best GWAS P=1.75e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-8.8	8.8	8.7e-19	-0.91	0.79	0.21	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-8.8	-8.9	5.2e-19	0.90	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	INCENP	0.23	0.05	lasso	3	0.03	3.8e-02	6.0	6.3	2.4e-10	-0.37	0.08	0.06	FALSE
4	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	-8.7	-9.2	2.4e-20	0.72	0.03	0.96	FALSE
5	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-8.3	-8.9	7.3e-19	0.68	0.07	0.84	TRUE
6	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-8.9	-9.0	2.8e-19	0.89	0.05	0.94	FALSE
7	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-9.8	9.1	8.8e-20	-0.92	0.01	0.99	FALSE
8	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-10.0	9.9	3.7e-23	-0.99	0.00	0.97	FALSE
9	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	-8.8	7.3	3.4e-13	-0.71	0.01	0.94	FALSE
10	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-6.8	-8.3	9.6e-17	0.71	0.02	0.68	FALSE
11	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	-8.7	-8.9	6.0e-19	0.64	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-8.3	-7.9	3.8e-15	0.75	0.04	0.95	FALSE
13	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	-6.5	-7.4	1.2e-13	0.55	0.06	0.83	TRUE
14	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-8.7	-9.5	1.8e-21	0.80	0.01	0.99	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	-8.7	-8.8	1.9e-18	0.63	0.05	0.93	FALSE
16	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-9.0	9.3	1.6e-20	-0.80	0.02	0.95	FALSE
17	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-8.7	-9.4	5.4e-21	0.73	0.69	0.31	FALSE
18	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	-8.7	-8.7	2.4e-18	0.64	0.12	0.74	FALSE
19	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-7.5	-8.6	5.4e-18	0.62	0.26	0.73	FALSE
20	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-8.9	-9.1	1.1e-19	0.78	0.36	0.60	FALSE
21	GTEx	Nerve Tibial	DAGLA	0.13	0.07	lasso	4	0.06	7.6e-05	5.0	-5.4	5.5e-08	0.24	0.18	0.03	FALSE
22	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	-8.7	-8.8	9.8e-19	0.65	0.91	0.09	FALSE
23	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-10.0	10.0	9.2e-24	-0.99	0.00	1.00	TRUE
24	GTEx	Spleen	MYRF	0.23	0.00	lasso	4	-0.01	4.6e-01	-6.2	-6.3	3.2e-10	0.43	0.03	0.47	FALSE
25	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-8.7	-9.4	5.2e-21	0.74	0.07	0.92	FALSE
26	GTEx	Testis	DAGLA	0.26	0.16	enet	11	0.09	1.1e-04	5.0	-5.5	4.9e-08	0.29	0.52	0.08	FALSE
27	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	-8.7	-8.8	1.6e-18	0.64	0.99	0.01	FALSE
28	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	1.4	-6.4	1.4e-10	0.53	0.03	0.35	TRUE
29	GTEx	Whole Blood	MS4A6A	0.05	0.03	lasso	5	0.03	6.1e-04	-5.4	5.4	5.4e-08	0.06	0.19	0.76	FALSE
30	GTEx	Whole Blood	MYRF	0.17	0.03	lasso	5	0.04	2.4e-04	5.0	-5.2	1.6e-07	0.18	0.53	0.02	TRUE
31	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	-8.7	-8.9	7.3e-19	0.66	1.00	0.00	FALSE
32	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	-8.7	-8.0	1.1e-15	0.60	0.96	0.02	FALSE
33	METSIM	Adipose	MS4A4A	0.04	0.04	blup	402	0.05	7.2e-08	2.9	5.4	5.6e-08	0.08	0.84	0.15	FALSE
34	METSIM	Adipose	MYRF	0.08	0.06	lasso	1	0.06	2.4e-09	5.2	-5.2	2.3e-07	0.25	1.00	0.00	FALSE
35	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-8.3	-8.1	5.1e-16	0.85	0.97	0.03	FALSE
36	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	-8.7	-9.1	8.2e-20	0.68	1.00	0.00	FALSE
37	NTR	Blood	MS4A6A	0.03	0.02	lasso	6	0.02	5.4e-07	-5.4	5.4	6.3e-08	0.05	0.30	0.70	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-8.3	-8.7	5.2e-18	0.84	0.98	0.02	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-9.0	9.5	1.4e-21	-0.94	0.02	0.98	FALSE
40	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-8.7	-9.9	6.3e-23	0.82	0.99	0.01	FALSE
41	YFS	Blood	MS4A6A	0.13	0.10	enet	33	0.11	2.5e-35	-5.9	5.4	5.8e-08	0.03	0.06	0.94	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	-1.0	5.3	1.3e-07	-0.67	0.01	0.67	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	-8.7	-8.6	6.2e-18	0.61	0.97	0.03	FALSE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-10.0	8.6	8.0e-18	-0.93	0.01	0.86	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-8.7	-9.4	5.6e-21	0.76	0.95	0.05	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	-8.7	-9.2	4.8e-20	0.69	0.28	0.66	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-8.7	-9.7	2.0e-22	0.72	1.00	0.00	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MS4A2	0.05	0.03	lasso	3	0.03	4.1e-04	-5.0	-5.6	2.8e-08	-0.01	0.07	0.65	TRUE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-8.7	-9.8	7.0e-23	0.80	0.22	0.78	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-7.9	8.8	2.0e-18	-0.74	0.26	0.71	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-8.8	7.3	3.8e-13	-0.84	0.02	0.94	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	-8.7	-9.1	1.0e-19	0.67	0.08	0.70	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-8.9	-8.9	5.0e-19	0.85	0.02	0.82	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	-8.7	-8.6	1.1e-17	0.64	0.38	0.44	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB3IL1	0.11	0.01	blup	68	0.04	1.4e-02	-6.7	6.5	6.8e-11	-0.35	0.01	0.61	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	-8.3	-7.4	1.7e-13	0.61	0.04	0.28	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-9.8	7.2	7.5e-13	-0.85	0.00	0.98	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	-8.7	-9.5	3.2e-21	0.71	0.70	0.21	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	MS4A2	0.04	0.02	lasso	2	0.02	1.3e-03	-5.4	-5.3	8.8e-08	-0.05	0.14	0.19	FALSE
60	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-8.7	-9.3	1.4e-20	0.72	0.02	0.97	FALSE
61	The Cancer Genome Atlas	Soft Tissue Sarcoma	C11orf9	0.08	0.01	enet	11	0.03	1.0e-02	-4.1	-5.3	1.1e-07	0.31	0.04	0.06	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-8.7	-9.0	2.5e-19	0.72	0.06	0.94	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	MS4A2	0.04	0.04	blup	55	0.04	8.2e-04	-5.4	-5.5	3.7e-08	-0.08	0.23	0.36	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-7.8	-9.6	8.5e-22	0.92	0.01	0.77	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-8.7	-9.4	3.3e-21	0.73	1.00	0.00	FALSE