Hub : Genes

PIF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0330	1.1e-03	0.030	0.017	0.036	0.020	0.042	1.3e-04	3.1e-03	3.0e-05	1.5e-03	7.1e-06
2	GTEx	Brain Caudate basal ganglia	0.1850	0.0790	7.4e-03	0.080	NA	0.059	NA	0.056	2.7e-03	NA	8.9e-03	NA	1.0e-02
3	GTEx	Brain Putamen basal ganglia	0.2270	0.0820	3.6e-03	0.170	NA	0.182	NA	0.161	7.8e-05	NA	4.3e-05	NA	1.2e-04
4	GTEx	Testis	0.1600	0.0720	3.3e-03	0.038	NA	0.112	NA	0.088	8.2e-03	NA	1.1e-05	NA	9.7e-05
5	GTEx	Thyroid	0.1810	0.0470	2.7e-09	0.142	NA	0.103	NA	0.124	5.6e-11	NA	2.6e-08	NA	9.9e-10
6	METSIM	Adipose	0.0471	0.0198	2.5e-04	0.024	0.036	0.018	0.034	0.019	1.5e-04	3.3e-06	7.7e-04	6.1e-06	5.3e-04
7	TCGA	Breast Invasive Carcinoma	0.1112	0.0464	1.7e-07	0.033	0.047	0.054	NA	0.046	2.3e-07	7.2e-10	3.2e-11	NA	8.7e-10
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0417	0.0303	4.5e-03	0.012	0.012	0.001	NA	0.005	1.3e-02	1.3e-02	2.4e-01	NA	7.6e-02
9	TCGA	Soft Tissue Sarcoma	0.1560	0.0630	4.2e-07	0.022	0.103	0.096	NA	0.067	1.8e-02	1.1e-06	2.6e-06	NA	7.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.5	2.4	5.3	0.3	1.6	1.6	-1.2	2.1	1.6	0.3	1.4	2.3
Bipolar Disorder or Schizophrenia	0.2	0.6	3.2	-0.5	0.2	0.3	0.3	0.4	0.8	-0.1	0.7	1.8
Depressed Affect (Nagel 2018)	2.2	4.7	11.3	2.3	1.8	2.0	-3.4	2.0	2.7	1.3	1.7	1.7
Depression (Nagel 2018)	1.7	2.5	8.0	2.8	2.0	1.7	-2.0	1.4	0.7	1.0	0.2	-0.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	12.5	0.8	0.5	0.6	-2.9	0.3	3.5	-1.0	-0.9	0.1
Neuroticism (Nagel 2018)	1.8	4.2	13.8	2.5	1.7	1.8	-3.7	1.6	1.3	1.0	1.4	2.0
Schizophrenia (2018)	0.4	0.7	1.9	-0.9	-1.0	-1.0	1.4	-1.2	-0.3	-0.3	-0.5	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.4	0.2	0.1	0.3	-0.4	-1.3	-0.6	-0.5	-0.6
Worry (Nagel 2018)	0.2	0.4	1.5	0.9	0.3	0.5	-1.0	0.1	-0.5	0.1	0.4	1.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.6	0.6	0.5	0.1	0.2	-0.7	-0.1	0.2	-0.3
Alzheimer’s Disease (in father)	1.2	1.3	4.0	2.0	1.4	1.2	0.1	0.6	-2.0	-0.2	0.4	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	1.2	1.0	0.9	0.2	0.3	-1.4	-0.4	0.0	-0.3
Crohns Disease (2017)	0.6	1.4	3.5	-1.0	0.2	0.7	-0.2	1.1	1.6	1.7	1.9	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.2	-0.4	-0.3	0.7	-0.2	0.9	0.0	-0.2	-0.8
Ulcerative Colitis (UC)	0.6	1.2	2.6	0.4	-0.7	-0.9	1.2	-1.1	-0.4	-1.1	-1.5	-1.6
Major Depression (MDD)	2.4	2.9	5.6	1.7	2.3	2.1	-1.8	2.4	0.5	1.2	1.6	0.8
Reaction Time	0.2	0.3	2.0	0.4	0.0	-0.0	0.4	0.0	-1.4	-0.4	0.0	0.6
Verbal and Numeric Reasoning (VNR)	1.5	3.6	9.4	1.1	1.8	1.9	-3.1	1.9	2.8	0.7	1.0	1.2
Breast Cancer	0.6	1.4	2.9	0.7	1.4	1.4	-0.4	1.3	-1.7	1.0	1.3	1.0
Ovarian Cancer	3.5	4.6	8.7	-0.6	-1.9	-2.0	2.2	-2.4	-1.0	-2.9	-2.6	-2.5
Prostate Cancer	1.3	1.8	4.9	0.6	1.5	1.6	-0.4	1.7	0.9	0.6	1.5	2.2
Age at First Birth	0.4	0.6	3.6	0.1	0.6	0.5	-0.9	0.7	1.9	0.1	-0.0	0.2
Bipolar Disorder (2011)	2.2	2.1	5.7	0.0	2.0	2.1	-0.5	2.4	-0.8	0.4	1.3	1.5
Body Mass Index (BMI) (2010)	0.7	1.0	2.6	-1.5	-1.0	-0.5	1.1	-0.0	0.7	0.5	1.1	1.6
Coronary Artery Disease (CAD)	0.9	1.1	3.6	-0.6	0.0	0.4	1.9	0.4	0.9	-0.4	-1.1	-1.9
Crohns Disease (2012)	0.8	1.2	2.8	-0.9	0.4	0.9	0.1	1.4	1.4	1.6	1.7	0.6
Mean Putamen Volume	0.5	0.6	4.2	-0.5	-0.1	0.1	-2.0	-0.4	0.7	0.2	-0.0	0.1
Fasting Glucose	1.4	1.7	4.9	2.0	1.7	1.4	-0.6	1.0	-2.2	0.0	-0.1	-0.5
HbA1C	0.7	0.8	1.8	0.9	1.0	1.1	-0.5	1.3	-0.7	0.1	1.0	0.5
HDL Cholesterol	0.5	0.8	1.6	-1.0	-1.1	-1.0	0.4	-1.2	-0.6	-0.9	-1.0	-0.5
LDL Cholesterol	1.2	1.9	3.8	0.3	1.2	1.1	-0.2	1.9	1.7	1.9	1.9	0.8
Lupus	4.9	7.4	13.3	-1.0	-2.5	-3.3	3.6	-3.4	-1.6	-1.4	-3.0	-3.2
Neuroticism (2016)	1.3	1.9	5.4	0.9	1.2	1.3	-2.3	0.8	0.8	2.0	0.7	1.5
Primary Biliary Cirrhosis	0.6	0.8	2.5	-0.1	-0.1	0.1	0.3	-0.4	1.2	-1.3	-1.6	-1.3
Rheumatoid Arthritis	1.8	2.4	8.9	-0.4	-1.1	-1.2	1.3	-1.4	-0.6	-3.0	-2.0	-1.6
Schizophrenia (2014)	0.2	0.4	0.8	-0.8	-0.0	-0.1	0.9	-0.2	0.9	0.3	0.2	0.9
Triglycerides	1.0	1.6	3.8	2.0	1.4	1.4	0.3	1.2	-1.5	0.5	0.4	-1.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.1	0.8	0.9	0.3	0.8	-0.4	0.0	0.0	-0.6
Ulcerative Colitis	0.6	0.8	2.5	0.8	0.1	0.0	0.8	-0.2	0.2	-1.3	-1.4	-1.6
Blood Eosinophil Count	1.1	8.6	20.8	0.1	-2.7	-3.2	1.6	-3.9	-0.7	-3.4	-4.6	-3.1
Blood Platelet Count	8.6	100.1	208.0	4.7	-5.4	-8.7	5.3	-10.1	-12.2	-11.0	-14.4	-12.8
Blood Red Count	0.1	0.8	3.4	-0.2	0.4	-0.0	-1.4	-0.4	1.8	0.1	0.2	1.3
Blood White Count	1.3	9.3	27.6	-2.0	-2.6	-2.7	2.9	-1.7	3.8	-1.4	-3.2	-5.2
Heel T-Score	0.2	1.4	5.5	-0.5	0.5	0.9	-2.4	1.3	1.7	0.6	0.8	-0.2
BMI	0.2	1.2	6.3	-0.9	-0.0	0.3	-0.2	0.1	1.5	0.7	0.6	2.5
Height	0.4	6.9	15.9	4.0	3.5	2.9	-3.9	2.2	-1.9	-0.3	1.1	0.2
Waist Hip Ratio (WHR)	0.1	0.4	1.4	-1.1	-0.3	0.0	-0.8	0.3	-1.2	0.2	0.6	-0.2
Systolic Blood Pressure	0.4	2.0	4.6	-0.4	-1.8	-2.1	1.1	-2.1	-2.0	-0.1	-0.4	0.8
Smoking Status	0.2	0.6	1.3	1.1	0.9	0.6	-0.8	0.8	-0.7	-0.8	0.4	0.0
Allergy or Eczema	0.7	1.9	4.0	2.0	0.3	-0.3	-2.0	-0.4	-0.5	-1.8	-1.8	-1.7
Cardiovascular Disease	0.3	0.9	4.8	0.4	-0.7	-0.6	-0.7	-0.7	0.1	0.7	0.7	2.2
Hypothyroidism (self reported)	1.8	4.1	7.9	1.7	2.7	2.8	-1.8	2.6	0.7	0.3	1.6	2.5
Respiratory disease	2.3	5.1	11.8	1.5	-1.1	-2.1	0.4	-2.1	0.2	-3.1	-3.4	-3.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	5.1	-2.2	-0.7	-0.5	0.3	-0.4	0.3	-0.4	-0.5	-0.3
Lung FEV1/FVC ratio	2.9	14.8	35.2	4.0	5.7	5.9	-2.1	4.7	-0.7	2.9	2.9	2.5
Lung FVC	0.5	2.6	6.5	2.5	2.1	2.2	-2.3	1.3	0.3	-0.5	-0.7	-0.1
Neuroticism	1.5	3.6	9.2	2.6	1.7	1.7	-3.0	1.7	1.3	1.3	1.3	1.5
Chronotype (morning person)	0.8	1.8	3.8	0.8	1.9	1.6	0.2	1.9	1.0	1.7	1.3	0.5
Hair Pigment	0.0	0.7	1.4	0.9	-0.5	-0.4	-0.1	-0.5	-1.0	-1.1	-1.1	-1.2
Tanning	0.1	1.7	3.6	-1.3	-1.7	-1.9	0.3	-1.9	-1.3	-1.2	-0.8	-0.1
Hand grip strength (left)	1.4	3.7	8.7	0.4	1.2	1.3	-2.5	1.2	-0.1	2.6	2.5	2.9
Number of treatments/medications taken	1.4	2.5	6.0	-1.2	-2.4	-2.4	1.0	-2.3	0.3	-0.9	-1.5	-0.5
Average weekly spirits intake	0.1	0.2	0.5	0.6	-0.1	-0.1	-0.4	-0.4	-0.3	-0.3	-0.7	-0.3
Sensitivity / hurt feelings	1.4	2.4	6.6	1.0	1.1	0.8	-2.6	1.0	0.5	1.8	1.8	2.1
Frequency of depressed mood in last 2 weeks	2.0	2.7	7.1	2.7	2.1	2.1	-2.0	1.8	0.4	0.8	0.8	0.5
Hearing difficulty/problems: Yes	1.2	1.8	6.5	1.5	-0.3	-0.5	-1.1	-0.6	-0.2	-2.5	-1.9	-1.6
Relative age of first facial hair	0.8	1.6	6.5	0.3	0.8	0.8	-0.4	1.4	0.6	2.5	1.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.1	1.4	0.5	0.6	-1.0	0.6	1.1	0.5	0.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	0.4	0.7	0.7	-0.9	0.6	0.2	0.6	0.4	-0.1
Ever had hysterectomy (womb removed)	1.1	1.2	5.8	0.2	-0.3	-0.5	0.9	-0.7	0.1	-1.1	-1.4	-2.4
Systolic blood pressure, automated reading	0.5	1.4	7.1	-0.5	-0.3	-0.6	-0.1	-0.5	-1.4	0.8	1.3	2.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	0.1	0.3	-0.6	0.1	-0.4	-0.1	-0.3	0.1
Angina	0.3	0.4	1.1	0.7	0.6	0.8	-0.8	1.0	-0.4	0.3	0.4	-0.3
Medication for hormone replacement therapy	0.5	0.6	2.1	-1.4	-0.8	-0.8	0.8	-0.7	0.3	0.3	-0.2	-0.7
Vitamin and mineral supplements	0.5	0.7	1.6	-0.6	0.4	0.6	-0.9	1.3	1.0	1.0	1.0	0.4
Supplements: Zinc	3.6	3.9	7.4	2.2	2.5	2.7	-2.2	2.1	0.2	1.8	1.3	1.6
Medication: Co-codamol	5.7	6.6	11.4	2.3	3.3	3.3	-1.7	3.4	0.1	2.0	2.8	2.6
Medication: Metformin	0.1	0.2	0.6	-0.8	0.1	0.2	0.2	0.0	-0.5	-0.7	-0.3	0.2
Diabetes (father)	0.6	0.7	1.5	1.2	1.2	1.0	-0.8	1.0	-0.2	0.9	0.5	-0.2
Diabetes (mother)	1.2	1.6	4.3	-2.1	-1.5	-1.5	1.5	-1.0	0.9	0.2	-0.4	-0.8
Severe depression (siblings)	0.9	1.0	2.5	-0.0	0.4	0.9	-0.9	1.2	-0.7	1.2	1.6	1.3
Pack years adult smoking proportion	0.8	1.2	4.1	-0.1	0.7	0.6	-1.0	1.2	0.4	1.3	2.0	1.2
Impedance of leg (right)	0.1	0.4	0.6	0.7	0.5	0.4	-0.5	0.7	-0.7	0.2	0.8	-0.7
Leg fat-free mass (left)	0.3	1.7	3.4	1.8	1.7	1.7	-1.8	1.1	-0.3	0.4	0.4	1.2
Trunk fat percentage	0.7	2.7	4.0	1.6	1.7	1.8	-2.0	1.8	1.2	1.5	1.2	1.6
Hand grip strength (right)	1.7	4.7	7.7	1.5	2.3	2.5	-2.4	2.1	0.2	2.3	2.3	2.8
Townsend deprivation index at recruitment	1.0	1.3	2.3	0.7	-1.0	-1.2	0.4	-1.5	-0.4	-1.4	-1.5	-1.5
Current tobacco smoking	0.2	0.3	1.4	1.2	0.3	0.0	-0.3	0.0	-0.9	-0.2	-0.1	-0.3
Average weekly fortified wine intake	2.1	2.5	6.1	-2.4	-2.0	-1.5	2.5	-1.7	0.3	0.1	-1.2	-0.3
Maternal smoking around birth	0.7	1.0	2.6	1.0	0.8	0.8	-1.6	0.7	0.4	0.9	1.1	1.4
Fed-up feelings	2.4	4.4	8.9	2.4	2.3	2.3	-3.0	2.3	1.8	1.6	1.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	5.0	2.2	1.0	0.7	-1.7	0.7	1.1	0.7	-0.0	0.0
Relative age voice broke	0.3	0.4	1.4	0.9	1.2	1.0	-0.1	0.8	-0.1	0.0	0.1	0.1
Taking other prescription medications	0.2	0.3	0.5	-0.7	-0.7	-0.7	0.2	-0.6	0.3	-0.4	-0.1	0.5
Age when periods started (menarche)	0.7	1.6	8.9	1.3	0.8	0.8	0.2	0.7	-3.0	0.5	0.0	-1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	4.1	-0.0	-0.2	-0.4	2.0	-0.7	-0.7	-0.5	-0.7	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.5	-0.1	-0.5	-0.3	-1.1	-0.0	1.2	-0.5	-0.3	-0.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.5	-0.0	0.8	1.0	-1.4	1.5	0.9	0.6	1.7	1.9
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.6	-0.1	-0.2	0.2	-0.3	-0.0	-0.6	-0.6	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.8	1.0	0.8	0.6	0.8	-0.3	0.4	0.2	-0.5
High blood pressure	0.6	1.7	4.5	-0.0	-1.9	-2.1	0.1	-2.1	-0.4	-0.8	-0.4	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.3	0.7	-0.3	-0.6	-1.3	-0.7	-0.6	-2.1	-1.6	-1.1
Multivitamins +/- minerals	0.1	0.1	0.4	0.6	-0.1	-0.1	-0.3	-0.5	0.1	-0.5	-0.2	-0.0
Stomach or abdominal pain in last month	0.4	0.5	1.2	1.0	0.8	0.7	0.7	0.4	-1.1	0.6	0.0	0.2
Supplements: Glucosamine	0.5	0.7	3.5	-1.1	-0.5	-0.3	0.7	-0.4	0.5	0.4	0.3	1.9
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	5.8	0.3	1.7	1.6	-0.2	1.6	-0.2	2.4	1.9	0.9
Medication: Atenolol	0.7	0.8	2.2	0.6	0.5	0.1	0.2	-0.0	-1.2	-1.5	-1.4	-1.2
Medication: Levothyroxine sodium	1.6	2.7	5.7	1.8	2.4	2.2	-1.3	1.9	0.2	1.1	1.3	1.7
Sitting height	0.3	1.8	5.3	2.3	1.5	1.4	-1.5	1.1	-1.4	-0.5	-0.1	-1.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.1	-0.6	-0.4	0.6	-0.3	-0.5	0.7	0.2	0.0
High blood pressure (mother)	1.7	2.4	5.4	-1.1	-2.2	-2.1	2.3	-1.9	0.1	-1.3	-0.9	0.0
Body mass index (BMI)	0.4	1.5	5.8	0.2	0.8	0.9	-1.2	0.8	0.8	1.5	1.0	2.4
Impedance of leg (left)	0.2	0.8	1.4	1.2	0.9	0.8	-0.5	1.0	-1.0	-0.2	0.6	-1.1
Leg predicted mass (left)	0.3	1.8	3.7	1.9	1.8	1.7	-1.9	1.1	-0.3	0.4	0.4	1.2
Trunk fat mass	0.8	3.4	6.1	1.8	2.0	2.1	-2.5	1.9	0.8	1.4	1.3	2.0
Waist circumference	0.5	1.8	4.6	0.8	1.3	1.4	-1.7	1.2	-0.2	1.2	1.1	2.1
Number of incorrect matches in round	0.9	1.5	4.7	-2.2	-1.0	-1.0	1.7	-1.0	-1.2	0.8	0.5	0.7
Past tobacco smoking	0.7	1.4	3.6	-1.6	-1.5	-1.1	1.9	-1.4	-0.7	-0.1	-0.7	0.0
Alcohol usually taken with meals	1.1	1.8	3.8	-0.8	-1.2	-1.3	0.6	-1.3	-0.1	-2.0	-2.0	-1.8
Nervous feelings	0.8	1.5	4.0	1.0	0.8	0.9	-1.3	0.6	-0.8	1.4	1.6	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.9	2.0	1.4	1.2	-0.9	0.9	0.9	0.7	0.5	-0.0
Hearing difficulty/problems with background noise	0.2	0.3	1.0	0.2	0.0	-0.3	-0.9	-0.2	0.4	-1.0	-0.2	-0.3
Hair/balding pattern: Pattern 2	1.9	2.4	5.7	2.4	1.8	1.6	0.3	1.3	-1.6	1.7	1.5	0.8
Had menopause	0.1	0.2	0.8	-0.7	-0.2	-0.2	-0.1	-0.2	-0.9	-0.0	0.2	0.3
Had other major operations	0.5	0.6	1.5	1.1	0.4	0.1	-0.7	-0.1	0.5	-1.2	-0.9	-0.7
Forced vital capacity (FVC)	0.5	2.0	5.4	2.3	1.9	1.9	-1.3	1.0	-0.7	-1.2	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.8	-0.9	-0.9	-0.6	-0.9	-0.2	1.3	-0.3	-0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.0	-0.2	-0.1	-0.3	-0.3	-0.4	-0.5	-0.5	-0.6
Qualifications: None of the above	1.2	2.6	7.2	0.4	0.8	0.9	-2.0	1.4	0.4	2.7	2.3	1.8
Financial difficulties in last 2 years	0.5	0.7	3.3	1.8	0.9	0.6	-0.2	0.6	-0.6	-0.9	-0.2	-0.7
Mouth/teeth dental problems	0.7	1.1	2.0	-0.4	-0.6	-0.8	1.4	-0.8	1.4	-1.1	-1.4	-1.2
Heart attack	1.0	1.3	5.9	0.3	-0.5	-0.6	-0.0	-0.7	-0.0	-0.9	-2.0	-2.4
Allergy	1.3	3.0	8.7	-1.5	0.5	1.1	0.8	1.5	0.4	2.5	2.9	2.2
Pain all over the body in last month	0.9	1.0	1.5	-1.0	-1.1	-1.2	0.8	-1.2	-0.9	-1.1	-0.7	-0.5
Diabetes (self-reported)	0.3	0.4	0.7	-0.7	0.6	0.8	-0.7	0.8	0.7	-0.1	0.2	0.8
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	4.0	-0.6	-1.8	-2.0	0.4	-1.8	-0.9	-1.7	-1.6	-1.4
Medication: Ramipril	1.9	2.4	7.2	-2.7	-1.9	-1.5	2.2	-1.4	1.1	-0.5	-0.2	0.6
Medication: Simvastatin	0.5	0.7	2.0	1.1	0.5	0.4	0.3	0.3	-1.4	-1.3	-0.9	-0.6
Fluid intelligence score	0.4	0.8	2.4	0.8	0.5	0.4	-1.6	-0.0	1.2	-1.0	-0.8	-0.6
Illnesses of siblings	0.2	0.3	1.6	-1.2	-0.0	0.2	0.3	0.2	-0.2	-0.2	-0.2	-0.7
Neuroticism score	1.8	3.8	6.4	2.0	1.7	1.9	-2.5	1.7	1.4	2.1	1.9	2.2
Weight	0.6	2.7	4.6	1.6	2.0	2.0	-2.1	1.6	-0.2	1.1	1.1	2.1
Impedance of arm (right)	0.2	0.8	2.6	-0.8	-1.1	-1.0	0.8	-0.6	0.8	-0.2	-0.4	-1.6
Arm fat percentage (right)	0.5	1.9	5.0	-0.1	0.7	0.9	-1.6	0.9	1.6	1.8	1.3	2.2
Trunk fat-free mass	0.4	2.4	4.5	2.1	1.8	1.6	-2.1	0.8	-1.8	0.1	0.5	1.8
Hip circumference	0.4	1.7	3.9	1.4	1.5	1.5	-1.3	1.2	0.6	1.0	0.7	2.0
Time employed in main current job	0.5	0.6	1.2	-0.6	-1.0	-1.0	0.4	-1.0	-0.4	1.1	-0.1	0.3
Alcohol intake versus 10 years previously	1.4	2.1	3.5	0.4	-1.5	-1.8	0.8	-1.8	-0.3	-1.6	-1.9	-1.7
Father’s age at death	0.3	0.4	1.5	-1.1	-0.5	-0.2	0.4	-0.3	-1.2	-0.1	0.4	0.7
Worrier / anxious feelings	1.8	3.4	6.5	0.2	1.6	1.9	-1.1	1.8	1.5	2.6	2.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	5.9	2.4	1.0	0.9	-1.5	0.5	0.1	0.0	-0.2	-0.8
Falls in the last year	1.0	1.4	2.4	1.5	1.1	1.1	-0.3	1.3	-1.6	0.9	1.5	0.9
Hair/balding pattern: Pattern 3	1.4	2.1	5.5	-2.4	-1.9	-1.8	0.2	-1.1	2.3	0.7	-0.2	0.0
Number of live births	0.5	0.6	1.5	0.1	-1.0	-1.0	-0.3	-1.0	-0.8	1.2	0.2	0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	8.4	2.9	2.8	2.8	-1.4	1.5	-0.9	-0.6	-0.4	-0.3
Pulse rate	1.3	2.2	6.5	-2.5	-1.7	-1.8	1.3	-1.4	1.7	-0.6	-0.5	-0.7
Happiness	1.9	2.3	4.5	0.9	1.7	1.9	-1.1	1.8	2.1	1.2	1.2	1.1
Noisy workplace	0.6	0.8	2.1	0.6	0.3	-0.1	-1.4	0.5	1.3	0.4	1.1	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.3	-1.5	-1.2	-1.1	-0.3	-1.3	-0.2	-1.8	-1.4	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.3	-0.1	-0.8	-0.8	0.7	-0.8	-1.1	-0.0	0.1	-0.1
Mouth/teeth dental problems: Dentures	1.2	2.0	6.6	1.4	1.7	1.6	-2.6	1.8	-0.6	0.1	0.8	-0.1
Asthma	2.7	5.3	13.1	0.3	-1.7	-2.2	1.6	-2.5	0.0	-2.9	-3.6	-3.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.6	0.0	-0.7	-0.6	-1.2	-0.2	1.9	1.3	-0.3	0.1
Medication: Cholesterol lowering	0.2	0.3	0.9	0.1	-0.3	-0.4	0.6	-0.3	-0.9	-0.9	-0.8	-0.3
Depression (self-reported)	0.9	1.1	4.1	0.9	0.7	1.1	-2.0	0.9	1.4	0.4	0.3	0.5
Medication: Lansoprazole	1.0	1.2	4.8	1.4	0.6	0.8	-1.3	0.7	-0.2	-0.3	0.7	2.2
Prospective memory result	0.6	0.7	1.8	1.3	1.3	1.0	-0.3	0.9	-0.2	0.3	0.5	0.8
Lung cancer (father)	1.9	2.3	4.8	1.8	1.9	1.8	-1.9	2.2	-0.3	0.5	1.2	0.3
Illnesses of mother	0.2	0.3	1.0	0.6	0.6	0.4	-0.4	-0.1	0.1	-0.3	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	9.7	3.1	2.6	2.5	-1.1	1.1	-1.3	-1.1	-1.0	-1.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.5	-0.1	0.6	-0.2	-0.3	-0.1
Impedance of arm (left)	0.1	0.5	3.3	0.2	-0.3	-0.5	0.4	-0.0	0.2	-0.5	-0.4	-1.8
Arm fat mass (right)	0.5	2.2	5.2	0.8	1.3	1.4	-2.0	1.2	0.8	1.6	1.2	2.3
Trunk predicted mass	0.4	2.2	4.2	2.1	1.7	1.5	-2.0	0.7	-1.7	0.0	0.4	1.7
Standing height	0.3	3.4	9.6	3.1	2.3	2.1	-1.8	1.4	-2.4	-0.9	0.1	-0.3
Length of working week for main job	0.6	0.7	1.9	0.3	-0.3	-0.2	0.7	-0.7	-1.1	-0.7	-1.1	-1.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.8	0.8	0.5	-0.3	0.0	0.7	-0.5	-0.4	-0.0
Breastfed as a baby	0.4	0.5	1.8	-0.5	-0.2	-0.2	0.4	-0.6	-1.4	-0.7	-0.7	0.6
Tense / ‘highly strung’	0.3	0.4	1.6	0.5	-0.3	-0.4	-1.3	-0.1	0.4	0.7	0.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	10.0	1.9	1.9	2.4	-2.1	2.3	0.2	1.8	2.3	3.2
Hair/balding pattern: Pattern 4	2.6	6.4	10.3	-2.7	-3.2	-2.9	3.1	-3.2	0.2	-1.7	-2.5	-1.5
Birth weight of first child	1.2	2.1	5.2	2.0	2.3	1.9	-0.7	1.7	-1.1	-0.9	-0.0	-0.8
Peak expiratory flow (PEF)	0.7	1.7	4.3	2.0	2.1	1.8	-0.4	0.7	-0.8	-0.5	-1.0	-1.1
Pulse wave reflection index	0.5	0.7	1.3	-0.2	-1.2	-1.1	1.0	-0.9	0.4	0.0	-0.8	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.4	-0.0	-0.4	0.0	-0.6	0.2	1.6	0.9	0.2	0.5
Loud music exposure frequency	0.6	0.6	2.4	-0.5	-0.9	-0.6	0.9	-0.6	-0.6	-1.6	-0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	-1.0	-0.1	-0.3	-0.3	-0.4	0.4	-1.1	-0.8	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	3.4	-0.4	-0.3	0.2	0.6	-0.3	-1.8	0.7	0.7	1.1
Blood clot in the leg (DVT)	0.7	1.0	2.7	0.9	1.5	1.6	-0.5	1.3	0.8	0.3	0.4	-0.3
Medication: Paracetamol	0.3	0.5	3.5	1.9	0.1	-0.0	0.1	-0.2	-0.4	0.1	-0.4	-0.4
Headache pain in last month	0.2	0.3	1.1	1.0	0.3	0.6	-0.9	0.2	-0.1	0.0	-0.3	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	0.2	0.7	0.7	-0.6	0.6	0.7	0.1	-0.0	-0.5
Glaucoma (self-reported)	2.1	2.5	11.7	-1.0	-1.2	-1.2	3.4	-0.9	-0.8	-1.2	-1.0	-1.7
Gout (self-reported)	0.8	1.1	2.0	0.1	-1.2	-1.1	-0.3	-1.4	-0.3	-0.9	-1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	1.5	2.8	6.0	1.6	2.4	2.2	-1.3	2.0	0.5	0.7	1.3	2.0
Medication: Amlodipine	2.5	3.5	7.7	-0.9	-2.8	-2.6	0.9	-2.7	-0.9	-1.8	-1.6	-1.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.7	-0.1	-1.4	-1.6	1.1	-1.5	-1.2	-1.5	-1.4	-1.1
Birth weight	1.1	2.3	5.6	1.3	1.9	2.1	-1.4	2.4	-0.4	1.3	1.1	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.5	0.1	-0.4	-0.4	-1.2	-0.3	-0.6	-0.7	0.1	-0.1
High blood pressure (siblings)	0.2	0.3	1.6	1.0	-0.1	-0.1	0.1	-0.2	-0.3	0.4	0.3	1.3
Forced vital capacity (FVC), Best measure	0.8	3.0	9.5	3.1	1.9	1.6	-1.3	0.6	-1.2	-1.7	-1.4	-1.5
Body fat percentage	0.7	2.7	4.5	1.1	1.5	1.6	-2.1	1.7	1.3	1.7	1.5	2.0
Leg fat percentage (right)	0.9	3.1	6.3	1.0	1.6	1.6	-2.5	1.6	1.0	1.8	1.8	2.4
Arm fat-free mass (right)	0.5	2.5	6.8	2.6	2.1	1.9	-1.8	1.0	-1.6	-0.5	-0.0	0.9
Exposure to tobacco smoke outside home	1.6	2.1	7.9	1.7	0.8	0.3	0.5	0.1	0.2	-2.0	-1.8	-2.8
Comparative body size at age 10	1.2	3.3	5.1	1.2	2.1	2.2	-1.6	2.1	2.1	1.0	1.3	2.1
Number of full brothers	0.4	0.5	1.0	0.0	1.0	0.8	0.2	0.6	-0.7	0.1	0.9	0.8
Worry too long after embarrassment	0.7	1.2	3.6	1.3	1.0	1.0	-0.7	1.0	0.1	1.9	1.1	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	5.2	0.8	1.2	1.7	-1.0	1.4	0.5	0.8	1.2	2.3
Wheeze or whistling in the chest in last year	0.1	0.2	1.1	0.6	0.2	-0.5	-1.1	-0.1	-0.2	-0.1	0.3	-0.1
Number of children fathered	1.2	1.3	3.7	0.2	1.3	1.5	0.1	1.9	-0.2	1.4	1.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.4	-0.3	-1.0	-0.8	0.1	-0.6	-0.0	-1.1	-0.2	1.2
Age at first live birth	1.2	2.2	5.2	-2.0	-1.5	-1.5	0.4	-1.5	1.1	-2.3	-1.5	-0.3
Pulse wave peak to peak time	0.2	0.3	0.8	0.9	0.5	0.5	-0.6	0.2	-0.9	0.0	0.2	0.1
Health satisfaction	0.4	0.5	1.6	0.4	0.2	0.6	-0.8	0.5	0.3	1.3	1.0	0.9
Shortness of breath walking on level ground	0.7	0.9	2.0	0.7	0.4	0.7	-1.4	1.2	0.4	1.2	1.3	0.4
Qualifications: College or University degree	2.7	8.6	15.5	-3.2	-3.6	-3.5	2.3	-3.9	-0.6	-3.6	-2.7	-0.8
Eye problems/disorders: None of the above	1.0	1.2	2.0	1.0	1.4	1.4	-1.0	1.2	-0.3	1.0	1.3	1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	1.4	1.1	0.9	-1.6	1.0	-1.6	0.4	1.1	1.2
Emphysema/chronic bronchitis	2.6	3.0	5.6	1.7	2.4	2.2	-1.2	2.3	0.7	1.8	1.4	1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.9	0.3	0.6	0.1	0.5	-0.7	-0.2	0.9	0.3
Neck or shoulder pain in last month	2.2	3.1	7.2	2.7	2.3	2.0	-2.5	2.0	-0.2	0.3	1.0	0.1
Medication: Blood pressure	0.2	0.3	1.1	-0.1	-0.6	-0.6	0.2	-0.5	0.0	-0.8	-0.0	1.0
Angina (self-reported)	0.3	0.4	1.2	0.5	0.6	0.8	-0.6	1.1	-0.3	0.4	0.5	-0.2
Migraine (self-reported)	2.6	3.2	8.4	-2.9	-2.6	-2.2	2.0	-1.9	-0.4	0.6	0.4	0.7
Medication: Ibuprofen	0.6	0.7	2.5	-0.3	-0.6	-0.4	-0.8	-0.0	1.6	1.5	-0.0	0.1
Medication: Allopurinol	0.4	0.5	2.3	1.5	0.5	0.2	-0.7	-0.3	0.3	-0.5	-0.9	-0.7
Medication: Omeprazole	0.5	0.6	3.3	0.6	0.3	0.2	-1.8	0.3	1.1	0.3	0.0	0.2
Medication: Seretide 50 evohaler	2.3	2.6	4.3	1.7	-1.0	-1.4	0.8	-1.9	-1.3	-2.0	-2.0	-2.1
Mean time to correctly identify matches	0.2	0.4	1.3	-0.5	-0.5	-0.5	0.7	-0.4	-1.1	-0.2	0.2	0.8
Heart disease (mother)	0.3	0.4	1.6	-0.6	-0.3	-0.2	0.3	-0.0	-1.3	0.2	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	6.2	-1.1	-0.0	0.2	0.6	0.6	0.5	2.5	1.9	1.2
Whole body fat mass	0.7	3.0	5.5	1.4	1.8	1.8	-2.3	1.6	0.9	1.6	1.4	2.3
Leg fat mass (right)	0.7	2.9	5.5	1.1	1.7	1.7	-2.3	1.6	0.6	1.6	1.6	2.3
Arm predicted mass (right)	0.6	2.9	6.7	2.6	2.3	2.2	-1.8	1.3	-1.6	-0.2	0.4	1.2
Pulse rate, automated reading	0.4	1.2	3.1	-1.8	-1.5	-1.4	1.3	-0.9	0.6	-0.3	-0.0	-0.8
Alcohol intake frequency.	0.3	0.8	2.2	-0.7	-1.1	-0.9	0.1	-1.1	-0.7	1.5	0.2	0.5
Comparative height size at age 10	0.7	3.6	6.5	2.2	2.5	2.5	-1.9	2.2	-1.6	1.0	1.3	1.3
Number of full sisters	0.4	0.4	2.3	0.5	-0.4	-0.2	0.3	-0.3	-1.5	0.6	-0.2	-0.8
Suffer from ‘nerves’	0.5	0.8	2.9	1.7	0.5	0.8	-0.5	-0.2	-1.1	-1.0	-0.6	0.6
Overall health rating	1.1	2.3	4.8	2.2	1.3	1.3	-2.1	1.5	1.5	1.1	1.2	0.8
Chest pain or discomfort	1.0	1.5	3.5	1.9	1.4	1.3	-0.9	0.9	-1.5	0.8	0.9	0.8
Had major operations	0.9	1.0	3.8	1.5	0.8	0.3	-0.9	0.6	-2.0	0.8	0.4	-0.5
Age at last live birth	0.9	1.3	2.4	-0.6	-1.0	-1.2	0.9	-1.5	-0.9	-1.5	-1.5	-0.6
Family relationship satisfaction	1.8	2.2	6.3	-2.1	-0.6	-0.1	1.8	0.1	2.5	2.0	0.9	0.9
Leg pain on walking	3.0	3.8	6.9	0.9	-1.5	-1.8	2.2	-1.9	-0.7	-2.3	-2.6	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	0.1	0.6	1.0	0.1	1.4	1.1	1.2	1.0	1.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.3	1.0	1.1	1.0	-2.1	1.1	-2.0	-0.6	-0.0	-1.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.6	-0.2	1.2	1.4	-0.4	1.2	1.1	1.0	1.3	1.9
Medication: Aspirin	1.2	1.5	3.7	-0.4	-0.8	-1.2	1.2	-1.0	-0.6	-1.3	-1.9	-1.9
Supplements: Vitamin C	1.0	1.2	4.6	2.1	0.8	0.6	0.1	0.1	-2.1	0.5	-0.4	-0.5
Knee pain experienced in last month	0.2	0.3	1.2	1.1	0.5	0.4	-0.0	0.4	-0.9	-0.1	-0.0	-0.2
Hypertension (Self-reported)	0.5	1.4	3.5	0.2	-1.7	-1.9	-0.1	-1.8	-0.1	-0.8	-0.3	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.4	1.1	0.9	1.2	-1.6	1.4	1.3	1.2	1.7	1.9
Illnesses of father: Heart disease	1.6	2.2	4.5	-1.1	-2.0	-2.0	0.6	-2.1	0.4	-0.5	-1.6	-1.5
Illnesses of siblings: Diabetes	1.2	1.5	4.3	-0.1	-0.9	-1.2	1.5	-1.3	-1.3	-2.1	-1.1	-0.7
Smoking status: Previous	1.4	2.1	4.8	1.5	1.7	1.3	-2.2	1.8	1.4	0.6	1.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	10.0	3.2	1.9	1.7	-1.8	1.0	-1.4	-0.5	0.0	-0.2
Whole body fat-free mass	0.4	2.2	4.6	2.2	1.9	1.7	-2.0	1.0	-1.3	0.1	0.4	1.5
Leg fat-free mass (right)	0.4	2.0	4.3	2.1	1.9	1.9	-1.7	1.2	-0.5	0.1	0.3	1.0
Arm fat percentage (left)	0.5	2.0	4.3	0.5	1.1	1.2	-1.8	1.2	1.3	1.7	1.3	2.1
Average weekly red wine intake	2.2	3.2	5.5	-1.4	-1.6	-1.9	1.2	-2.1	-1.2	-2.2	-2.4	-1.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	0.8	0.2	0.5	-1.4	0.2	0.5	-0.9	-0.9	-0.5
Mood swings	1.4	2.5	6.2	1.1	1.0	1.3	-2.5	1.2	1.9	1.9	1.4	1.4
Loneliness, isolation	2.0	2.7	5.3	1.7	1.6	1.6	-2.3	1.5	1.5	0.3	1.3	2.3
Long-standing illness, disability or infirmity	0.4	0.7	2.4	0.2	-0.6	-0.5	0.5	-0.4	1.6	-1.2	-0.7	-0.7
Ever had bowel cancer screening	0.1	0.1	0.5	0.4	0.3	0.0	-0.3	0.1	0.0	0.7	-0.0	-0.3
Diabetes diagnosed by doctor	0.3	0.4	1.2	-1.0	0.1	0.3	-0.4	0.3	1.1	-0.9	-0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.5	0.4	-0.0	-0.4	-0.4	-0.4	0.7	-0.4	-0.2	0.1
Friendships satisfaction	1.3	1.6	4.8	-2.2	-1.4	-0.9	0.3	-0.7	2.1	1.1	0.5	0.9
Qualifications: nursing, teaching	1.0	1.5	4.5	-0.6	-0.8	-1.1	0.5	-1.1	-1.0	-1.6	-1.4	-2.1
Commuting to job workplace: Walk	0.3	0.3	1.7	-0.1	0.2	0.2	1.3	-0.3	0.3	0.8	-0.1	0.7
Eye problems/disorders: Cataract	0.6	0.7	4.5	0.0	-0.7	-0.8	-0.2	-0.6	2.1	-0.1	-0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-1.1	-0.7	-0.6	-0.3	-0.6	0.4	0.7	0.4	1.1
Medication for cholesterol	1.1	1.6	3.4	0.5	1.4	1.6	-0.3	1.8	0.6	1.5	1.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	-0.8	-0.3	-0.3	0.3	-0.2	0.8	1.3	0.8	0.8
Back pain experienced in last month	1.9	2.8	7.0	2.6	1.7	1.5	-2.5	1.3	-1.9	0.6	1.1	-0.3
Mineral and other dietary supplements	0.3	0.4	0.8	-0.6	-0.9	-0.8	0.3	-0.5	-0.2	-0.1	-0.8	-0.9
Breast cancer (self-reported)	1.8	2.2	4.4	-1.9	-2.1	-1.6	2.0	-1.6	0.9	-0.9	-0.9	-0.1
Asthma (self-reported)	3.1	6.1	15.3	0.6	-1.7	-2.4	1.5	-2.6	-0.1	-3.1	-3.9	-3.4
Osteoporosis (self-reported)	0.1	0.2	0.6	0.3	0.4	0.2	-0.8	0.5	-0.1	0.2	0.4	0.1
Osteoarthritis (self-reported)	0.9	1.1	3.4	-0.1	0.7	0.9	0.2	0.9	-1.3	0.8	1.5	1.8
Medication: Aspirin	0.5	0.7	1.7	-0.1	-0.5	-0.7	1.0	-0.6	-0.5	-0.7	-1.3	-1.3
Medication: Gliclazide	0.8	0.9	3.0	-0.3	0.3	0.1	0.0	-0.0	1.1	-1.0	-1.5	-1.7
Illnesses of father: None of the above (group 1)	2.2	2.7	6.6	1.6	2.4	2.6	-1.4	2.6	0.1	0.1	1.0	-0.0
Smoking status: Current	0.1	0.2	0.8	0.5	-0.2	-0.3	0.1	-0.4	-0.9	-0.4	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.3	1.0	2.0	2.3	-1.4	1.5	0.4	0.8	0.5	1.0
Whole body water mass	0.4	2.2	4.7	2.2	1.9	1.8	-2.0	1.0	-1.3	0.2	0.4	1.4
Leg predicted mass (right)	0.4	1.9	4.4	2.1	1.9	1.9	-1.7	1.2	-0.6	0.1	0.3	0.9
Arm fat mass (left)	0.5	2.2	5.3	1.0	1.5	1.5	-1.9	1.3	0.7	1.5	1.2	2.3
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.9	-0.2	-0.5	-0.1	-0.7	-0.7	-0.6	-0.8	-0.1
Average weekly champagne plus white wine intake	2.2	3.0	6.5	0.9	-0.3	-0.6	1.5	-1.2	-2.1	-2.2	-2.5	-2.6
Miserableness	1.2	2.2	5.5	1.5	0.9	1.0	-2.3	1.1	2.3	1.6	0.8	0.4
Guilty feelings	1.7	2.5	6.6	2.6	1.6	1.5	-2.5	1.1	-0.4	0.7	1.0	1.5
Wears glasses or contact lenses	0.7	0.8	2.3	-0.9	-1.4	-1.5	-0.0	-1.2	0.8	0.0	0.0	0.3
Ever taken oral contraceptive pill	0.7	0.7	2.0	1.4	1.1	1.3	-0.7	0.8	0.9	-0.1	0.2	0.2
Hearing aid user	0.8	0.9	2.3	-0.6	-1.2	-1.5	0.4	-1.3	-0.2	-1.0	-1.0	-0.5
Mother’s age at death	2.5	3.2	5.1	-1.6	-2.2	-2.1	2.3	-2.2	-1.8	-0.3	-1.3	-1.3
Financial situation satisfaction	0.2	0.2	0.8	0.1	0.0	0.0	0.8	0.1	0.6	-0.2	-0.2	-0.9
Tinnitus: Yes, now most or all of the time	3.4	3.9	6.7	-0.5	-2.2	-2.2	0.1	-2.6	-1.6	-2.3	-2.5	-2.2
Commuting to job workplace: Public transport	1.3	1.5	3.0	-1.3	-1.6	-1.6	1.7	-1.6	0.4	-0.6	-0.9	0.5
Eye problems/disorders: Glaucoma	2.0	2.4	8.2	-1.2	-1.5	-1.4	2.9	-1.3	-1.0	-1.0	-1.2	-1.5
Medication: Blood pressure	1.0	1.9	4.8	-0.2	-1.7	-1.9	0.2	-2.2	-1.0	-1.5	-1.5	-0.6
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.0	1.4	1.9	2.0	-1.5	1.8	0.1	0.6	0.6	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.4	-0.5	0.5	0.5	0.4	0.5	0.4	1.0	1.2	1.1
High cholesterol (Self-reported)	0.0	0.1	0.3	-0.3	-0.0	-0.0	-0.2	0.1	-0.3	0.6	0.1	0.1
Medication: Bendroflumethiazide	0.6	0.8	1.8	0.3	-1.0	-1.4	-0.7	-1.3	0.4	-0.9	-1.1	0.6
Medication: Paracetamol	0.2	0.4	2.4	1.5	0.2	0.1	0.5	-0.1	-0.1	0.2	-0.6	-0.4
Medication: Lisinopril	0.4	0.6	1.5	1.1	-0.3	-0.2	-0.4	-0.4	1.2	-1.0	-0.8	0.1
Medication: Atorvastatin	0.4	0.5	3.2	-0.1	-0.5	-0.5	-0.3	-0.3	1.8	0.3	-0.7	-0.4
Illnesses of father: High blood pressure	1.4	1.8	4.4	-1.7	-1.8	-2.1	0.8	-1.9	0.2	0.2	-0.1	1.0
Alcohol drinker status: Never	3.1	3.7	6.4	-2.5	-2.4	-2.4	2.1	-2.3	0.6	-0.4	-1.7	-1.3
Ever smoked	0.4	0.6	1.7	1.3	1.2	0.9	-0.7	1.0	0.1	0.1	0.4	-0.4
Basal metabolic rate	0.4	2.4	4.5	2.1	2.0	1.9	-2.1	1.1	-1.1	0.4	0.5	1.6
Leg fat percentage (left)	0.9	3.2	6.4	1.1	1.8	1.8	-2.5	1.8	0.9	1.6	1.8	2.2
Arm fat-free mass (left)	0.4	1.9	3.5	1.9	1.8	1.7	-1.6	0.9	-1.2	0.0	0.4	1.5
Number of operations (self-reported)	0.4	0.6	4.0	0.5	0.4	0.1	-2.0	0.2	0.7	0.0	0.4	0.3
Average weekly beer plus cider intake	1.3	1.9	4.7	0.6	0.9	1.1	-1.7	1.2	0.9	2.2	1.9	0.9
Irritability	2.1	3.5	5.9	1.5	1.8	1.9	-2.4	2.1	0.7	2.0	2.1	1.8
Risk taking	0.5	0.7	2.4	1.5	0.9	0.9	-0.6	0.8	-1.0	0.2	0.2	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	-0.8	-0.6	-0.5	1.3	-0.8	0.5	0.5	-0.4	0.3
Fractured/broken bones in last 5 years	0.7	1.0	3.5	1.9	0.3	-0.1	-0.8	0.3	-1.4	-0.1	-0.0	-1.5
Age started oral contraceptive pill	1.7	2.2	6.3	-2.4	-1.7	-1.3	2.5	-1.3	-0.1	-0.3	-0.9	-0.6
Diastolic blood pressure, automated reading	0.9	2.7	4.9	2.2	2.2	1.5	-1.8	1.4	0.5	1.2	1.1	2.0
Ever depressed for a whole week	0.5	0.7	2.5	0.9	0.9	0.8	0.3	0.5	-1.6	0.8	0.1	-0.1
Unable to work because of sickness or disability	1.0	1.2	4.6	2.1	0.9	0.6	-1.9	0.7	-0.9	0.1	0.6	0.5
Commuting to job workplace: Cycle	0.8	1.0	1.8	-1.1	-1.3	-1.0	0.6	-1.1	0.4	-1.2	-1.1	-0.6
Myopia	0.7	1.0	5.6	1.1	0.5	0.3	-1.1	0.5	2.4	0.6	0.1	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.1	-0.7	1.2	1.4	-0.1	1.4	0.4	0.6	0.4	-1.1
Cholesterol lowering medication	0.4	0.6	1.8	0.3	-0.3	-0.3	0.1	-0.6	-0.2	-1.0	-1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	6.7	0.3	0.4	0.4	-2.6	0.6	2.1	0.9	0.7	0.6
Pain experienced in last month	0.7	1.2	2.7	-0.9	-1.1	-1.0	1.3	-1.1	0.4	-1.6	-1.2	-0.5
Supplements: Calcium	1.1	1.3	5.2	2.3	1.4	0.9	-1.1	0.8	-0.0	1.2	0.2	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	2.4	-1.4	0.1	0.1	-0.7	0.9	1.0	1.5	1.5	0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	6.1	0.3	-0.4	-0.6	0.1	-0.8	0.2	-0.9	-2.1	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.8	0.9	1.6	1.7	-0.8	1.4	1.1	0.1	0.5	-0.2
Heart disease (siblings)	1.0	1.2	3.4	0.2	-0.5	-0.5	1.9	-0.8	0.5	-1.3	-1.6	-1.3
Alcohol drinker status: Previous	0.5	0.6	2.4	1.6	0.2	0.1	-1.4	-0.1	0.1	0.8	0.4	-0.2
Pack years of smoking	1.0	1.4	4.4	0.1	0.8	0.8	-0.8	1.4	0.4	1.6	2.1	1.3
Impedance of whole body	0.1	0.5	3.4	0.5	0.1	-0.1	0.1	0.3	0.2	-0.7	-0.2	-1.8
Leg fat mass (left)	0.8	2.9	5.2	1.1	1.8	1.9	-2.2	1.7	0.5	1.6	1.6	2.3
Arm predicted mass (left)	0.4	1.8	3.6	1.9	1.8	1.6	-1.6	0.9	-1.1	0.1	0.3	1.4