TWAS hub - CSNK1G1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1730	0.0460	4.7e-09	0.171	NA	0.130	NA	0.154	7.6e-13	NA	6.2e-10	NA	1.3e-11
2	GTEx	Colon Transverse	0.0710	0.0380	9.9e-03	-0.003	NA	-0.005	NA	0.010	4.9e-01	NA	6.8e-01	NA	1.0e-01
3	YFS	Blood	0.0067	0.0048	4.4e-02	0.000	0.003	0.000	0.003	0.001	2.6e-01	0.039	3.8e-01	0.03	1.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Illnesses of father: None of the above (group 1)	12.8	15.8	18.4	-3.4	-4.3	-4.2
Vitamin and mineral supplements	7.8	10.6	15.6	-2.8	-2.9	-4.0
Illnesses of father: High blood pressure	7.7	9.5	12.4	2.6	3.1	3.5
Multivitamins +/- minerals	7.6	9.6	14.5	3.4	1.8	3.8
Blood White Count	7.4	54.8	102.0	-10.1	-3.5	-7.1
Commuting to job workplace: Public transport	5.9	7.1	13.6	1.2	3.7	2.5
Number of children fathered	5.2	5.9	7.4	-2.2	-2.3	-2.7
Lung cancer (father)	4.7	5.5	9.2	-2.3	-1.4	-3.0
Angina	4.2	5.5	8.0	-2.8	-1.4	-2.6
Deep venous thrombosis (DVT) (self-reported)	4.2	5.3	8.8	-3.0	-0.2	-2.7
Wheeze or whistling in the chest in last year	4.0	7.2	8.9	2.5	3.0	2.5
Systolic blood pressure, automated reading	3.9	11.3	14.7	3.8	2.9	3.3
Exposure to tobacco smoke at home	3.9	4.4	4.7	2.2	2.1	2.1
Blood clot in the leg (DVT)	3.8	4.9	8.0	-2.8	0.0	-2.6
Angina (self-reported)	3.7	4.8	7.3	-2.7	-1.1	-2.4
Mean Putamen Volume	3.6	4.1	7.0	2.6	0.2	2.3
Mineral and other dietary supplements	3.6	4.8	9.5	-2.2	-0.4	-3.1
Qualifications: College or University degree	3.4	10.8	17.6	3.0	2.5	4.2
Hearing difficulty/problems with background noise	3.3	5.3	9.8	1.9	3.1	1.6
Respiratory disease	3.2	7.2	12.1	1.4	3.5	2.8
Coronary Artery Disease (CAD)	3.0	3.5	5.3	-2.3	0.8	-2.1
High blood pressure	3.0	8.5	11.3	2.6	3.4	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.5	6.6	2.6	1.2	2.4
Average weekly champagne plus white wine intake	3.0	4.2	5.2	-2.0	-2.3	-1.9
Unable to work because of sickness or disability	3.0	3.9	5.9	-1.3	-2.1	-2.4
Crohns Disease (2012)	2.9	4.6	8.7	-1.6	-3.0	-1.6
Asthma	2.8	5.6	8.1	1.6	2.8	2.5
Blood Red Count	2.7	26.4	33.6	5.6	5.8	3.8
Hypertension (Self-reported)	2.7	7.6	10.8	2.4	3.3	2.5
Asthma (self-reported)	2.7	5.4	8.9	1.3	3.0	2.4
Triglycerides	2.6	4.3	7.1	-2.1	2.7	-1.2
Age when periods started (menarche)	2.6	6.4	8.6	-2.9	-1.6	-2.8
Medication: Lansoprazole	2.5	2.8	6.0	2.5	-0.7	1.4
Alzheimer’s Disease (in father)	2.4	2.6	3.5	1.1	1.9	1.8
Fasting Glucose	2.4	2.9	8.2	-0.6	2.9	-0.3
Suffer from ‘nerves’	2.4	3.8	4.4	2.1	1.6	2.1
Illnesses of father: Heart disease	2.4	3.3	8.4	0.4	2.9	1.2
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	4.6	-1.7	-1.1	-2.2
Medication: Metformin	2.3	3.3	9.5	-0.0	3.1	0.6
Cardiovascular Disease	2.2	7.3	11.1	2.0	3.3	2.6
Bipolar Disorder or Schizophrenia	2.1	5.1	8.0	2.8	-0.3	2.7
Systolic Blood Pressure	2.1	10.6	13.9	2.8	3.7	3.2
Crohns Disease (2017)	2.0	4.5	10.5	-1.0	-3.2	-1.4
Breast Cancer	2.0	4.8	11.7	1.1	3.4	1.3
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.9	-2.0	1.5	-0.8
Exposure to tobacco smoke outside home	2.0	2.7	7.5	-0.8	2.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	4.0	1.6	1.1	2.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.6	1.5	1.1	1.9
Vascular/heart problems diagnosed by doctor	2.0	5.5	8.4	-1.9	-2.9	-2.1
Schizophrenia (2014)	1.9	4.3	6.7	2.6	0.6	2.4
Type 2 Diabetes (T2D) (2018)	1.9	3.5	10.4	-0.3	3.2	0.1
Number of treatments/medications taken	1.9	3.3	5.5	1.1	2.4	1.8
Diabetes (father)	1.9	2.4	6.2	0.3	2.5	0.9
Pain all over the body in last month	1.9	2.0	2.9	1.2	1.3	1.7
Illnesses of siblings: Diabetes	1.9	2.3	3.1	0.9	1.7	1.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.9	1.5	-0.4	2.2
Alzheimer’s Disease (including proxy)	1.8	2.7	4.6	0.8	2.1	1.7
Nervous feelings	1.8	3.3	5.7	2.4	0.6	2.0
Allergy	1.8	4.2	5.0	-1.8	-2.2	-2.1
Headache pain in last month	1.8	3.1	3.4	-1.6	-1.7	-1.9
Birth weight	1.8	3.8	3.9	-1.9	-2.0	-1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	-2.1	0.1	-1.6
Schizophrenia (2018)	1.7	3.4	5.6	2.4	-0.2	2.2
Hearing aid user	1.7	1.9	4.5	0.8	2.1	0.8
Ever had hysterectomy (womb removed)	1.6	1.8	2.9	-1.6	-0.3	-1.7
Taking other prescription medications	1.6	2.5	6.1	0.8	2.5	0.9
Fluid intelligence score	1.6	3.4	5.8	1.3	2.4	1.6
Noisy workplace	1.6	2.0	4.1	2.0	0.7	1.2
Supplements: Vitamin C	1.6	1.9	5.0	0.3	2.2	0.8
Waist Hip Ratio (WHR)	1.5	6.8	18.1	-1.5	4.2	-0.2
Relative age of first facial hair	1.5	3.1	5.4	-1.2	-2.3	-1.6
Medication: Simvastatin	1.5	2.2	5.2	-2.3	0.6	-1.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.3	1.0	1.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	5.3	1.4	1.5	2.3
Supplements: Glucosamine	1.4	1.8	3.2	1.5	-0.2	1.8
Falls in the last year	1.4	1.8	3.4	-1.4	-0.0	-1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.0	6.9	1.3	0.6	2.6
Prospective memory result	1.4	1.7	3.0	1.0	-1.7	1.1
Breastfed as a baby	1.4	1.7	2.4	1.4	0.8	1.6
Diabetes diagnosed by doctor	1.4	2.3	6.7	-0.4	2.6	0.2
Medication: Paracetamol	1.4	2.1	3.6	-1.3	-1.0	-1.9
Average weekly beer plus cider intake	1.4	2.0	3.9	1.2	2.0	0.8
Worry (Nagel 2018)	1.3	2.7	4.7	1.8	-0.2	2.2
HbA1C	1.3	1.5	4.3	-0.1	2.1	0.3
Sitting height	1.3	9.0	23.7	-1.3	4.9	1.2
Had menopause	1.3	1.6	2.1	1.4	1.2	1.1
Illnesses of siblings	1.3	1.9	3.0	-0.9	-1.7	-1.3
Medication: Paracetamol	1.3	2.1	3.3	-0.9	-1.5	-1.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.7	-1.0	-0.9	-1.6
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.6	0.1	1.4
Diabetes (self-reported)	1.2	1.8	4.3	-0.8	2.1	-0.6
Loneliness, isolation	1.2	1.7	2.2	1.5	1.2	1.1
Friendships satisfaction	1.2	1.5	2.4	1.5	1.1	1.0
Bipolar Disorder (2018)	1.1	1.7	2.8	1.6	-0.1	1.7
Major Depression (MDD)	1.1	1.3	3.0	-0.6	1.7	-0.8
Pack years adult smoking proportion	1.1	1.7	4.4	2.1	-0.1	0.7
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.4	1.8	1.0	1.9
Alcohol usually taken with meals	1.1	1.8	4.0	-1.1	-2.0	-0.5
Medication: Ramipril	1.1	1.4	3.1	0.6	0.9	1.8
Pulse wave Arterial Stiffness index	1.1	1.3	2.7	-1.6	0.3	-1.1
Leg pain on walking	1.1	1.4	2.1	-1.4	-1.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.8	1.6	0.4	1.7
Breast cancer (self-reported)	1.1	1.3	3.4	-0.4	-1.8	-0.6
Miserableness	1.1	2.0	4.8	0.4	2.2	1.0
Fractured/broken bones in last 5 years	1.1	1.5	2.3	-1.4	0.1	-1.5
Depressed Affect (Nagel 2018)	1.0	2.1	4.9	0.5	2.2	1.0
Neuroticism (Nagel 2018)	1.0	2.3	3.5	1.4	1.2	1.9
Irritable Bowel Disease (IBD)	1.0	2.3	6.7	-0.2	-2.6	-0.3
LDL Cholesterol	1.0	1.6	2.1	-0.8	-1.4	-1.4
Hand grip strength (left)	1.0	2.6	4.5	2.1	-1.2	1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.2	2.1	-1.4	-0.2	-1.2
Severe depression (siblings)	1.0	1.1	2.6	-0.5	-1.6	-0.7
Townsend deprivation index at recruitment	1.0	1.4	3.5	0.5	1.9	0.8
Hair/balding pattern: Pattern 2	1.0	1.3	1.7	-1.3	-1.1	-0.9
Number of live births	1.0	1.5	2.9	1.7	0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.0	-1.2	-0.5	-1.4
Impedance of arm (left)	1.0	4.7	5.4	-2.1	-2.1	-2.3
High blood pressure (siblings)	1.0	1.4	2.2	0.8	1.5	1.2
Number of full brothers	1.0	1.3	1.9	0.6	1.2	1.4
Pulse wave peak to peak time	1.0	1.2	2.2	1.5	-0.3	1.1
Ever had bowel cancer screening	1.0	1.1	2.7	-0.6	-1.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	1.8	1.4	0.5	1.3
Alcohol drinker status: Previous	1.0	1.1	3.1	-0.0	1.8	-0.6
Pack years of smoking	1.0	1.4	3.8	1.9	-0.1	0.7
Rheumatoid Arthritis	0.9	1.3	1.8	1.2	0.8	1.3
Allergy or Eczema	0.9	2.4	3.0	1.4	1.5	1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.5	-0.1	1.9	0.2
Medication for hormone replacement therapy	0.9	1.1	2.9	-0.0	1.7	0.5
Hand grip strength (right)	0.9	2.5	3.7	1.9	-1.6	1.1
Qualifications: None of the above	0.9	1.9	2.9	-0.6	-1.7	-1.5
Impedance of arm (right)	0.9	4.2	4.6	-2.1	-2.1	-1.9
Glaucoma (self-reported)	0.9	1.0	2.9	-1.7	0.1	-0.4
Gout (self-reported)	0.9	1.2	3.1	-1.8	-0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.4	-0.3	2.3	0.0
Commuting to job workplace: Walk	0.9	1.0	1.7	0.7	0.9	1.3
Financial situation satisfaction	0.9	1.1	2.7	-1.6	0.3	-0.8
Medication: Blood pressure	0.9	1.8	3.3	1.2	1.8	0.8
Risk taking	0.9	1.4	2.4	-1.5	0.8	-1.1
Diastolic blood pressure, automated reading	0.9	2.6	3.5	1.9	1.6	1.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.4	-1.6	0.2	-0.9
Body Mass Index (BMI) (2010)	0.8	1.2	1.4	1.0	1.2	1.0
Heel T-Score	0.8	6.4	18.4	-0.8	4.3	0.0
Hypothyroidism (self reported)	0.8	1.9	5.4	-0.5	2.3	-0.3
Hearing difficulty/problems: Yes	0.8	1.2	2.7	-0.9	1.6	-0.3
Financial difficulties in last 2 years	0.8	1.1	2.4	-0.8	0.5	-1.6
Heart attack	0.8	1.0	2.1	-1.5	0.3	-0.8
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	1.5	0.2	1.1
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	-1.6	0.5	-1.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.3	1.0	-1.5	-0.8
Medication: Ibuprofen	0.8	1.0	1.7	-1.1	-0.1	-1.3
Number of full sisters	0.8	0.9	2.6	-0.2	1.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.3	0.2	1.5	-0.4
Medication: Aspirin	0.8	1.1	2.6	-1.6	0.3	-0.7
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	-1.6	0.2	-0.2
Myopia	0.8	1.2	3.1	-1.8	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.8	0.9	2.4	1.5	-0.2	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.4	0.6	1.9	1.6
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.1	0.8	1.8	1.2
Age at First Birth	0.7	1.1	2.4	-0.6	-1.5	-0.7
Neuroticism (2016)	0.7	1.0	2.6	0.4	1.6	0.5
Primary Biliary Cirrhosis	0.7	0.9	1.8	0.8	0.6	1.4
Smoking Status	0.7	1.6	2.2	-1.0	-1.3	-1.5
Trunk fat percentage	0.7	2.8	7.2	-1.0	-0.3	-2.7
Medication: Atenolol	0.7	0.9	1.5	-0.7	0.8	-1.2
Medication: Levothyroxine sodium	0.7	1.2	2.7	0.7	1.6	0.7
Time employed in main current job	0.7	0.8	1.1	0.9	-1.0	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.5	-1.2	0.7	-1.2
Medication: Cholesterol lowering	0.7	1.1	2.7	-1.6	0.8	0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	-0.0	1.4	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	1.1	1.2	0.3
Overall health rating	0.7	1.5	3.1	-1.2	0.1	-1.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	1.1	0.0	1.1
Medication for cholesterol	0.7	1.1	3.3	0.2	-1.8	-0.1
Osteoporosis (self-reported)	0.7	0.8	2.1	0.1	-1.5	-0.5
Medication: Gliclazide	0.7	0.8	2.0	-0.7	1.4	-0.0
Age started oral contraceptive pill	0.7	0.8	0.9	-0.8	-1.0	-0.9
Pain experienced in last month	0.7	1.2	2.1	1.2	0.1	1.4
Reaction Time	0.6	1.1	2.9	0.6	-1.7	-0.2
BMI	0.6	3.4	6.5	1.7	2.6	0.8
Supplements: Zinc	0.6	0.6	1.1	0.4	1.1	0.7
Diabetes (mother)	0.6	0.8	2.1	0.1	1.4	0.4
Current tobacco smoking	0.6	1.0	1.9	-0.5	-0.9	-1.4
Maternal smoking around birth	0.6	0.9	1.3	1.2	0.9	0.8
Serious illness, injury or assault to yourself	0.6	0.7	0.8	-0.9	0.9	-0.8
Number of incorrect matches in round	0.6	1.1	2.5	0.8	0.3	1.6
Trunk fat-free mass	0.6	3.7	5.1	1.7	1.8	2.2
Father’s age at death	0.6	0.8	1.2	0.4	1.1	1.0
Worrier / anxious feelings	0.6	1.2	1.8	1.3	-0.1	1.4
Depression (self-reported)	0.6	0.7	1.7	0.6	-1.3	-0.3
Trunk predicted mass	0.6	3.5	4.8	1.6	1.8	2.2
Peak expiratory flow (PEF)	0.6	1.4	3.8	-0.5	2.0	0.1
Comparative body size at age 10	0.6	1.6	3.9	-0.8	-0.5	-2.0
Health satisfaction	0.6	0.8	1.0	1.0	0.7	0.9
Medication: Blood pressure	0.6	1.1	2.3	-0.5	1.5	0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.5	0.2	1.2	0.7
Alcohol intake frequency.	0.6	1.4	3.6	1.9	-0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.1	1.1	-0.3	1.0
Medication: Atorvastatin	0.6	0.7	1.5	-1.2	-0.7	-0.4
Ever smoked	0.6	1.1	1.5	-1.2	0.3	-1.2
Heart disease (siblings)	0.6	0.8	1.9	-0.1	1.4	0.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-1.0	0.8	-0.4
Ovarian Cancer	0.5	0.6	1.2	-0.5	1.1	0.7
Lupus	0.5	0.8	1.2	1.1	0.3	1.1
Height	0.5	9.4	12.7	1.9	3.4	3.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	0.8	-0.7	0.7
Stomach or abdominal pain in last month	0.5	0.7	0.9	-1.0	-0.7	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.2	0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.2	1.3	0.5
Tense / ‘highly strung’	0.5	0.9	1.0	0.9	-1.0	0.8
Birth weight of first child	0.5	0.9	2.3	-1.5	0.3	-0.5
Pulse wave reflection index	0.5	0.6	1.2	-1.1	0.4	-0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.6	0.7	0.5	1.3
Arm fat-free mass (right)	0.5	2.7	5.7	1.0	2.4	1.1
Neck or shoulder pain in last month	0.5	0.8	1.0	-1.0	0.8	-0.8
Arm predicted mass (right)	0.5	2.4	5.6	0.9	2.4	1.0
Chest pain or discomfort	0.5	0.7	1.7	0.5	1.3	-0.3
Medication: Aspirin	0.5	0.6	1.6	-1.3	0.4	-0.5
Average weekly red wine intake	0.5	0.8	2.0	0.5	0.4	1.4
Back pain experienced in last month	0.5	0.8	1.5	-0.9	-0.0	-1.2
Guilty feelings	0.5	0.7	0.8	0.8	0.8	0.9
Mother’s age at death	0.5	0.6	1.3	1.1	-0.6	0.5
Medication: Bendroflumethiazide	0.5	0.8	1.2	0.5	0.9	1.1
Arm fat-free mass (left)	0.5	2.7	4.8	1.2	2.2	1.4
Ulcerative Colitis (UC)	0.4	0.8	1.4	0.8	-1.2	0.7
HDL Cholesterol	0.4	0.7	1.1	1.0	-0.8	0.7
Waist circumference	0.4	1.5	3.1	-0.4	1.8	-1.1
Past tobacco smoking	0.4	0.7	1.1	1.1	-0.7	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-1.1	-0.5	-0.3
Happiness	0.4	0.5	1.0	-0.6	-0.1	-1.0
Medication: Amlodipine	0.4	0.6	1.1	0.4	1.0	0.7
Body fat percentage	0.4	1.4	4.1	-0.2	0.2	-2.0
Age at first live birth	0.4	0.8	2.2	0.1	-0.3	1.5
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.9	-0.2	-0.7
Mean time to correctly identify matches	0.4	0.7	1.3	1.1	-0.7	0.6
Heart disease (mother)	0.4	0.4	0.7	0.7	0.2	0.9
Pulse rate, automated reading	0.4	1.3	2.8	-1.7	-0.9	-0.6
Had major operations	0.4	0.5	0.8	-0.9	0.5	-0.7
Smoking status: Previous	0.4	0.7	1.4	-1.2	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	-0.8	1.4	-0.1
Arm fat percentage (left)	0.4	1.7	4.7	-0.1	-0.7	-2.2
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-0.2	1.3	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	2.0	-0.0	1.4	0.0
Ever taken oral contraceptive pill	0.4	0.4	1.2	-1.1	-0.1	-0.2
Arm predicted mass (left)	0.4	2.2	4.5	1.0	2.1	1.1
Depression (Nagel 2018)	0.3	0.5	1.1	-0.2	1.1	-0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.4	-0.9	-0.3
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.2	-0.9	0.2
Ulcerative Colitis	0.3	0.4	1.2	-0.2	-1.1	-0.2
Sensitivity / hurt feelings	0.3	0.5	0.8	0.9	0.1	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.5	-0.2	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.9	0.4	-0.5
High blood pressure (mother)	0.3	0.4	0.8	0.3	0.6	0.9
Trunk fat mass	0.3	1.1	3.1	-0.5	0.3	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	0.5	0.4	1.4
Arm fat percentage (right)	0.3	1.2	3.3	-0.0	-0.6	-1.8
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	0.7	0.5	1.2
Loud music exposure frequency	0.3	0.4	0.9	-0.9	-0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.2	-0.8	-0.6
Leg fat percentage (right)	0.3	0.9	1.4	0.8	1.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.4	0.2	-1.0
Migraine (self-reported)	0.3	0.4	1.0	1.0	0.0	0.5
Medication: Allopurinol	0.3	0.3	0.9	-1.0	0.1	-0.3
Age at last live birth	0.3	0.4	0.9	0.2	-0.4	1.0
Family relationship satisfaction	0.3	0.4	1.1	-0.1	1.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	-0.4	0.3
Whole body fat-free mass	0.3	1.6	2.2	0.9	1.5	1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.5	0.7	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.6	-0.8	-0.4
Whole body water mass	0.3	1.5	2.2	0.9	1.5	1.2
Leg fat percentage (left)	0.3	1.1	1.8	0.6	1.3	-1.1
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.1	0.8	0.6
Cholesterol lowering medication	0.3	0.5	0.8	-0.9	-0.0	-0.9
Impedance of whole body	0.3	1.6	2.9	-1.7	-0.2	-1.3
Prostate Cancer	0.2	0.2	0.4	0.5	0.7	-0.1
Blood Eosinophil Count	0.2	1.5	3.8	0.0	2.0	0.8
Lung FVC	0.2	1.1	2.6	-0.3	-1.6	-0.7
Average weekly spirits intake	0.2	0.3	0.6	-0.3	0.4	-0.8
Medication: Co-codamol	0.2	0.2	0.6	-0.1	-0.1	-0.8
Fed-up feelings	0.2	0.4	0.9	0.4	1.0	0.2
Relative age voice broke	0.2	0.3	0.4	0.4	-0.7	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.3	0.7	0.4
Impedance of leg (left)	0.2	1.0	2.7	-0.6	1.6	-0.1
Had other major operations	0.2	0.3	0.7	-0.2	-0.2	-0.8
Neuroticism score	0.2	0.4	0.7	0.9	0.2	0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.5	0.1	0.7	0.4
Pulse rate	0.2	0.4	0.8	-0.3	0.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	-0.6	1.1	0.1
Arm fat mass (right)	0.2	0.6	1.9	0.0	0.1	-1.4
Standing height	0.2	1.5	2.9	-0.6	1.7	1.1
Length of working week for main job	0.2	0.2	0.3	-0.6	0.5	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.5	0.3	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	-0.4	-0.5	-0.4
Whole body fat mass	0.2	0.6	1.4	0.2	0.7	-1.2
Leg fat mass (right)	0.2	0.7	1.3	0.7	1.1	-0.6
Comparative height size at age 10	0.2	1.4	2.4	0.6	1.5	1.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.0	-0.7	0.5
Smoking status: Current	0.2	0.4	0.7	-0.1	-0.6	-0.9
Arm fat mass (left)	0.2	0.7	2.0	0.1	-0.0	-1.4
Wears glasses or contact lenses	0.2	0.2	0.5	0.2	0.1	0.7
Alcohol drinker status: Never	0.2	0.2	0.5	0.3	-0.3	0.7
Basal metabolic rate	0.2	1.1	2.3	0.7	1.5	0.7
Supplements: Calcium	0.2	0.2	0.4	0.4	0.1	0.7
Leg fat mass (left)	0.2	0.7	1.3	0.5	1.1	-0.8
Blood Platelet Count	0.1	1.5	3.0	-1.7	-1.0	-0.7
Lung FEV1/FVC ratio	0.1	0.7	1.1	-0.7	-0.8	-1.1
Chronotype (morning person)	0.1	0.1	0.2	-0.4	-0.4	0.0
Hair Pigment	0.1	2.6	3.9	-2.0	0.1	-1.9
Tanning	0.1	1.8	2.4	1.5	-1.0	1.4
Impedance of leg (right)	0.1	0.7	2.1	-0.1	1.4	0.3
Average weekly fortified wine intake	0.1	0.1	0.3	-0.0	0.3	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.3	-0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	0.1	-0.3
Body mass index (BMI)	0.1	0.5	0.7	0.7	0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.5	-0.2	-0.3
Forced vital capacity (FVC)	0.1	0.5	0.7	0.6	0.6	0.8
Weight	0.1	0.6	1.5	0.4	1.2	-0.4
Hip circumference	0.1	0.2	0.4	0.2	0.6	-0.6
Illnesses of mother	0.1	0.2	0.3	0.5	-0.5	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	-0.0	1.0	0.6
Worry too long after embarrassment	0.1	0.2	0.4	0.6	-0.3	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.2	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.2	-0.4	0.5	-0.3
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	0.5	-0.2
Mood swings	0.1	0.2	0.4	0.6	0.3	0.3
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.8	-0.2	0.1
Medication: Lisinopril	0.1	0.1	0.2	-0.5	0.2	0.2
Irritability	0.1	0.1	0.2	-0.1	-0.5	-0.4
Neuroticism	0.0	0.1	0.3	0.2	-0.0	0.5
Leg fat-free mass (left)	0.0	0.1	0.3	-0.0	0.5	-0.1
Leg predicted mass (left)	0.0	0.1	0.3	0.0	0.5	-0.1
Mouth/teeth dental problems	0.0	0.1	0.1	0.3	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.3	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	-0.1	0.3	0.3
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	-0.2	0.2	-0.3
Eye problems/disorders: None of the above	0.0	0.1	0.1	0.1	0.2	-0.3
Medication: Omeprazole	0.0	0.0	0.0	0.2	-0.1	0.1
Leg fat-free mass (right)	0.0	0.1	0.3	-0.2	0.6	-0.2
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.4	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.3	0.3	0.0
Leg predicted mass (right)	0.0	0.2	0.4	-0.2	0.6	-0.2
Number of operations (self-reported)	0.0	0.0	0.1	-0.0	0.4	0.1
Ever depressed for a whole week	0.0	0.0	0.1	0.3	0.2	0.1

Hub : Genes

CSNK1G1

Models

Trait associations