Hub : Genes

PPIB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Lung Squamous Cell Carcinoma 0.0618 0.034 0.00100 0.037 0.033 0.016 NA 0.033 4.8e-05 0.00010 0.0053 NA 9.8e-05
2 TCGA Stomach Adenocarcinoma 0.1680 0.078 0.00064 0.002 0.042 0.013 NA 0.004 2.4e-01 0.00053 0.0370 NA 1.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 3.1 -1.8 0.6
Bipolar Disorder or Schizophrenia 1.8 4.4 8.5 -2.9 0.5
Depressed Affect (Nagel 2018) 0.6 1.2 1.6 -0.9 1.3
Depression (Nagel 2018) 0.1 0.1 0.1 0.4 0.2
Intelligence (Savage-Jansen 2018) 2.4 7.5 14.8 -0.4 3.9
Neuroticism (Nagel 2018) 0.9 2.0 2.3 -1.5 1.3
Schizophrenia (2018) 1.3 2.8 5.5 -2.3 0.2
Schizophrenia vs Biploar Disorder 0.3 0.5 0.6 -0.6 -0.8
Worry (Nagel 2018) 1.7 3.5 4.3 -2.1 1.7
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 0.7 -0.0
Alzheimer’s Disease (in father) 0.8 0.8 1.1 -1.0 -0.8
Alzheimer’s Disease (including proxy) 0.3 0.4 0.8 -0.9 -0.0
Crohns Disease (2017) 0.2 0.5 0.9 0.9 0.5
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 0.2 0.9
Ulcerative Colitis (UC) 0.4 0.7 1.0 -0.7 1.0
Major Depression (MDD) 1.3 1.6 2.5 0.8 -1.6
Reaction Time 0.3 0.5 1.0 -0.3 -1.0
Verbal and Numeric Reasoning (VNR) 1.2 2.9 5.3 -0.7 2.3
Breast Cancer 0.2 0.4 0.8 -0.9 -0.2
Ovarian Cancer 0.3 0.4 0.8 -0.1 0.9
Prostate Cancer 0.1 0.1 0.2 -0.4 -0.2
Age at First Birth 2.0 2.9 5.8 0.3 2.4
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.3 -0.8
Body Mass Index (BMI) (2010) 0.5 0.6 1.2 -1.1 0.1
Coronary Artery Disease (CAD) 2.4 2.9 5.2 2.3 0.8
Crohns Disease (2012) 1.0 1.6 2.9 1.7 0.5
Mean Putamen Volume 4.8 5.5 10.2 -3.2 -0.8
Fasting Glucose 0.5 0.6 1.1 0.3 -1.0
HbA1C 0.1 0.1 0.3 -0.1 0.5
HDL Cholesterol 0.3 0.5 0.8 -0.9 -0.4
LDL Cholesterol 0.5 0.8 1.1 1.1 0.7
Lupus 0.1 0.2 0.3 -0.5 -0.1
Neuroticism (2016) 0.7 1.0 1.8 -0.4 1.4
Primary Biliary Cirrhosis 0.7 0.9 1.0 -0.9 1.0
Rheumatoid Arthritis 1.4 2.0 3.4 -0.8 1.8
Schizophrenia (2014) 1.6 3.6 6.9 -2.6 0.6
Triglycerides 2.4 3.9 4.2 1.9 -2.1
Type 2 Diabetes (T2D) (2012) 1.9 2.2 2.2 1.5 1.5
Ulcerative Colitis 0.2 0.4 0.6 0.3 0.8
Blood Eosinophil Count 0.2 1.8 3.4 0.3 1.9
Blood Platelet Count 0.6 7.4 8.7 2.5 -2.9
Blood Red Count 1.7 16.4 31.1 -5.6 1.3
Blood White Count 5.8 42.9 85.2 9.2 0.8
Heel T-Score 0.5 3.8 7.4 0.4 -2.7
BMI 0.7 3.9 4.7 -2.2 1.7
Height 0.1 2.9 5.4 -2.3 -0.6
Waist Hip Ratio (WHR) 0.3 1.2 2.0 1.4 -0.7
Systolic Blood Pressure 1.0 4.8 8.0 -2.8 1.3
Smoking Status 0.2 0.4 0.8 0.9 -0.2
Allergy or Eczema 0.5 1.4 2.0 -1.4 0.8
Cardiovascular Disease 1.4 4.6 6.0 -2.4 1.8
Hypothyroidism (self reported) 0.2 0.4 0.9 0.1 0.9
Respiratory disease 0.6 1.3 1.6 -1.0 1.3
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 0.0 -0.5
Lung FEV1/FVC ratio 0.0 0.1 0.2 0.5 0.0
Lung FVC 0.1 0.7 1.3 -0.2 -1.1
Neuroticism 0.1 0.3 0.4 -0.4 0.6
Chronotype (morning person) 0.3 0.7 1.3 0.4 1.2
Hair Pigment 0.1 3.2 3.6 1.7 -1.9
Tanning 0.1 1.6 2.4 -1.5 -0.9
Hand grip strength (left) 0.8 2.1 3.4 -1.9 -0.9
Number of treatments/medications taken 2.3 4.1 7.2 -1.0 2.7
Average weekly spirits intake 0.0 0.0 0.1 0.1 -0.3
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.8 0.1
Frequency of depressed mood in last 2 weeks 0.4 0.6 0.6 0.8 0.8
Hearing difficulty/problems: Yes 1.6 2.4 3.9 1.0 2.0
Relative age of first facial hair 1.3 2.7 4.8 0.8 -2.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 1.9 1.4 -0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.2 -0.0 1.1
Ever had hysterectomy (womb removed) 1.2 1.3 2.1 1.5 -0.8
Systolic blood pressure, automated reading 2.5 7.4 12.5 -3.5 1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.8 0.9 -0.7
Angina 4.5 5.8 7.6 2.8 -2.0
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.1 -0.5
Vitamin and mineral supplements 5.7 7.7 8.3 2.9 -2.7
Supplements: Zinc 0.3 0.3 0.6 -0.1 0.8
Medication: Co-codamol 1.1 1.2 2.5 -0.1 -1.6
Medication: Metformin 0.8 1.1 2.2 -0.2 -1.5
Diabetes (father) 1.4 1.7 3.4 -0.2 -1.8
Diabetes (mother) 0.1 0.1 0.1 -0.3 -0.3
Severe depression (siblings) 0.1 0.1 0.1 0.3 -0.2
Pack years adult smoking proportion 1.3 2.0 3.5 -1.9 -0.7
Impedance of leg (right) 0.1 0.4 0.5 0.6 -0.7
Leg fat-free mass (left) 0.1 0.4 0.4 -0.6 -0.7
Trunk fat percentage 0.1 0.3 0.4 0.7 -0.5
Hand grip strength (right) 0.6 1.7 3.4 -1.8 0.0
Townsend deprivation index at recruitment 0.5 0.8 1.0 -1.0 0.8
Current tobacco smoking 0.3 0.5 0.6 0.5 -0.8
Average weekly fortified wine intake 0.3 0.3 0.6 0.0 0.8
Maternal smoking around birth 0.8 1.2 1.5 -1.2 -0.9
Fed-up feelings 0.3 0.6 1.0 -0.5 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 -0.1 -0.4
Relative age voice broke 0.4 0.6 0.9 -0.5 -0.9
Taking other prescription medications 0.9 1.4 2.3 -0.7 1.5
Age when periods started (menarche) 2.5 6.0 9.3 3.1 -1.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.3 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 3.7 -1.9 -0.6
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 1.5 -1.2 0.9
Qualifications: CSEs or equivalent 0.1 0.2 0.3 0.5 0.2
Serious illness, injury or assault to yourself 0.4 0.5 0.9 0.9 -0.3
High blood pressure 1.9 5.4 7.3 -2.7 1.9
Hayfever, allergic rhinitis or eczema 1.3 2.8 3.0 -1.7 1.6
Multivitamins +/- minerals 6.8 8.6 11.8 -3.4 2.3
Stomach or abdominal pain in last month 1.2 1.5 2.9 1.7 0.2
Supplements: Glucosamine 1.2 1.5 2.2 -1.5 0.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.6 -0.8 -0.6
Medication: Atenolol 0.5 0.6 0.7 0.8 0.7
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.7 0.2
Sitting height 0.2 1.3 1.8 0.9 -1.3
Chronic bronchitis/emphysema (father) 0.4 0.5 0.9 -1.0 -0.3
High blood pressure (mother) 1.2 1.6 3.2 -0.3 1.8
Body mass index (BMI) 0.2 0.7 1.4 -1.2 0.0
Impedance of leg (left) 0.1 0.5 0.9 1.0 -0.3
Leg predicted mass (left) 0.1 0.4 0.4 -0.6 -0.6
Trunk fat mass 0.0 0.1 0.2 0.0 -0.4
Waist circumference 0.0 0.0 0.0 0.1 -0.0
Number of incorrect matches in round 0.1 0.2 0.3 -0.5 -0.2
Past tobacco smoking 0.4 0.7 0.8 -0.9 -0.8
Alcohol usually taken with meals 0.5 0.7 1.2 1.1 0.5
Nervous feelings 1.2 2.2 4.0 -2.0 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.5 0.5 1.2
Hearing difficulty/problems with background noise 1.7 2.7 3.1 -1.5 1.8
Hair/balding pattern: Pattern 2 1.2 1.5 2.3 1.5 -0.8
Had menopause 0.7 0.9 1.7 -1.3 -0.1
Had other major operations 0.0 0.0 0.0 -0.2 -0.1
Forced vital capacity (FVC) 0.3 1.2 1.5 -1.2 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 1.9 -0.8 -1.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.8 0.9 0.5
Qualifications: None of the above 0.6 1.4 2.5 0.5 -1.6
Financial difficulties in last 2 years 0.1 0.2 0.2 0.5 -0.4
Mouth/teeth dental problems 1.2 1.9 3.7 -0.0 1.9
Heart attack 0.4 0.5 1.1 1.0 0.1
Allergy 1.7 3.8 5.1 1.6 -2.3
Pain all over the body in last month 1.1 1.2 1.5 -1.2 0.9
Diabetes (self-reported) 0.2 0.4 0.5 0.5 -0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 0.1 0.7
Medication: Ramipril 0.9 1.2 1.7 -0.8 1.3
Medication: Simvastatin 1.9 2.8 5.5 2.4 -0.0
Fluid intelligence score 1.0 2.0 2.3 -1.3 1.5
Illnesses of siblings 0.5 0.7 1.4 1.2 0.3
Neuroticism score 0.7 1.4 1.9 -0.9 1.4
Weight 0.1 0.5 0.8 -0.9 -0.4
Impedance of arm (right) 0.7 3.2 5.7 2.4 -0.8
Arm fat percentage (right) 0.0 0.1 0.2 -0.4 -0.3
Trunk fat-free mass 0.4 2.1 4.3 -2.1 0.1
Hip circumference 0.1 0.4 0.4 -0.7 0.6
Time employed in main current job 0.8 0.9 1.1 -0.8 -1.1
Alcohol intake versus 10 years previously 0.2 0.3 0.5 -0.4 0.7
Father’s age at death 0.6 0.8 1.5 -0.1 -1.2
Worrier / anxious feelings 1.0 1.9 2.2 -1.3 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.0 1.4 0.5
Falls in the last year 0.8 1.1 1.4 0.8 -1.2
Hair/balding pattern: Pattern 3 0.8 1.1 2.2 -1.5 0.1
Number of live births 1.2 1.7 2.0 -1.4 -1.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.4 -0.6 -0.7
Pulse rate 0.9 1.6 3.1 0.1 1.8
Happiness 1.2 1.5 2.6 0.6 1.6
Noisy workplace 2.3 2.9 3.3 -1.8 1.6
Qualifications: A levels/AS levels or equivalent 0.9 2.1 2.7 -1.2 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.3 -0.5 -0.5
Mouth/teeth dental problems: Dentures 1.3 2.1 3.5 1.9 -0.9
Asthma 1.8 3.6 5.8 -1.2 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.8 -0.2
Medication: Cholesterol lowering 0.9 1.4 2.6 1.6 -0.4
Depression (self-reported) 0.2 0.2 0.4 -0.6 0.1
Medication: Lansoprazole 3.6 4.1 4.7 -2.2 1.8
Prospective memory result 0.6 0.8 1.2 -1.1 -0.6
Lung cancer (father) 3.3 3.9 4.6 2.2 -1.8
Illnesses of mother 0.3 0.4 0.6 -0.4 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 -0.0 -0.8
Pulse wave Arterial Stiffness index 0.8 1.0 1.8 1.3 0.4
Impedance of arm (left) 0.8 3.5 5.9 2.4 -1.0
Arm fat mass (right) 0.0 0.2 0.2 -0.5 -0.3
Trunk predicted mass 0.3 2.0 4.0 -2.0 0.1
Standing height 0.1 0.6 1.0 0.4 -1.0
Length of working week for main job 0.1 0.2 0.3 0.5 -0.2
Exposure to tobacco smoke at home 3.1 3.5 4.1 -2.0 1.7
Breastfed as a baby 1.4 1.8 2.0 -1.3 -1.4
Tense / ‘highly strung’ 0.7 1.2 1.4 -1.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.1 8.0 -2.8 0.5
Hair/balding pattern: Pattern 4 0.7 1.7 2.8 -0.7 1.7
Birth weight of first child 1.4 2.6 4.0 1.1 -2.0
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.1 -0.1
Pulse wave reflection index 0.3 0.3 0.5 0.7 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.4 0.1
Loud music exposure frequency 1.5 1.6 2.7 0.7 1.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.7 -0.0
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.6 -0.7 -1.6
Blood clot in the leg (DVT) 2.6 3.4 5.7 2.4 -1.0
Medication: Paracetamol 0.4 0.6 0.9 0.9 0.5
Headache pain in last month 1.2 2.0 2.2 1.3 1.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.5 -0.7 -0.4
Glaucoma (self-reported) 1.5 1.7 3.3 1.8 -0.4
Gout (self-reported) 0.7 1.0 1.6 1.2 -0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 0.1 0.8
Medication: Amlodipine 0.2 0.3 0.7 -0.8 0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 -0.7 -0.3
Birth weight 1.8 4.0 5.5 1.6 -2.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.8 0.3 -1.3
High blood pressure (siblings) 0.4 0.6 1.2 -1.1 0.0
Forced vital capacity (FVC), Best measure 0.1 0.5 0.8 -0.5 -0.9
Body fat percentage 0.0 0.1 0.1 -0.1 -0.3
Leg fat percentage (right) 0.2 0.7 1.3 -1.1 -0.3
Arm fat-free mass (right) 0.2 1.0 2.0 -1.4 0.1
Exposure to tobacco smoke outside home 0.5 0.6 0.6 0.8 0.8
Comparative body size at age 10 0.4 1.0 1.1 1.1 0.9
Number of full brothers 0.3 0.4 0.5 -0.7 0.6
Worry too long after embarrassment 0.0 0.0 0.0 -0.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 3.1 -1.8 -0.0
Wheeze or whistling in the chest in last year 1.7 3.0 5.9 -2.4 0.4
Number of children fathered 2.2 2.4 4.4 2.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 5.4 6.3 11.8 -0.9 3.4
Age at first live birth 0.9 1.5 2.9 -0.5 1.7
Pulse wave peak to peak time 0.7 0.8 1.6 -1.3 -0.3
Health satisfaction 0.5 0.7 1.1 -1.1 0.4
Shortness of breath walking on level ground 2.1 2.5 4.8 0.4 -2.2
Qualifications: College or University degree 2.3 7.2 8.0 -2.8 2.5
Eye problems/disorders: None of the above 0.2 0.3 0.6 -0.1 -0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 0.4 -1.6
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.1 -0.2
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 -0.3 -1.0
Neck or shoulder pain in last month 0.3 0.5 0.7 0.8 -0.5
Medication: Blood pressure 0.5 0.9 1.7 0.1 1.3
Angina (self-reported) 4.2 5.5 6.7 2.6 -2.1
Migraine (self-reported) 0.4 0.6 1.0 -1.0 0.3
Medication: Ibuprofen 0.3 0.4 0.7 0.8 -0.2
Medication: Allopurinol 0.1 0.1 0.3 0.5 -0.0
Medication: Omeprazole 0.3 0.4 0.7 -0.3 0.8
Medication: Seretide 50 evohaler 0.9 1.1 2.1 -0.2 1.4
Mean time to correctly identify matches 0.2 0.3 0.6 -0.8 -0.1
Heart disease (mother) 0.1 0.1 0.2 -0.3 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.4 0.3 0.6
Whole body fat mass 0.0 0.2 0.4 -0.6 -0.2
Leg fat mass (right) 0.2 0.7 1.2 -1.1 -0.4
Arm predicted mass (right) 0.2 0.9 1.7 -1.3 -0.1
Pulse rate, automated reading 0.3 0.9 1.6 1.3 0.3
Alcohol intake frequency. 0.7 1.5 2.1 -1.5 -1.0
Comparative height size at age 10 0.1 0.7 0.8 -0.7 -0.9
Number of full sisters 0.4 0.5 1.0 -0.0 -1.0
Suffer from ‘nerves’ 3.7 5.8 7.6 -2.0 2.7
Overall health rating 1.0 2.1 3.0 1.1 1.7
Chest pain or discomfort 0.1 0.2 0.3 -0.4 -0.5
Had major operations 2.3 2.8 4.6 0.9 -2.2
Age at last live birth 0.1 0.2 0.3 -0.3 0.6
Family relationship satisfaction 0.5 0.6 1.2 -0.1 1.1
Leg pain on walking 1.1 1.3 1.6 1.3 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 0.4 0.5
Commuting to job workplace: Car/motor vehicle 2.8 3.2 3.9 1.6 -2.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.8 -0.9 0.3
Medication: Aspirin 0.5 0.6 1.2 1.1 0.1
Supplements: Vitamin C 0.1 0.1 0.1 -0.2 0.3
Knee pain experienced in last month 0.0 0.0 0.0 -0.0 -0.1
Hypertension (Self-reported) 2.0 5.5 6.2 -2.5 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 3.4 -0.9 1.9
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.3 -0.6
Illnesses of siblings: Diabetes 0.6 0.7 1.2 -1.1 0.4
Smoking status: Previous 0.5 0.7 1.1 1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 6.5 0.6 -2.5
Whole body fat-free mass 0.2 1.1 2.2 -1.5 -0.2
Leg fat-free mass (right) 0.0 0.2 0.3 -0.4 -0.5
Arm fat percentage (left) 0.0 0.1 0.2 -0.3 -0.4
Average weekly red wine intake 0.2 0.3 0.6 -0.3 0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 0.8 0.1
Mood swings 0.2 0.4 0.7 -0.9 -0.3
Loneliness, isolation 2.3 3.2 3.8 -1.6 2.0
Long-standing illness, disability or infirmity 1.9 3.0 6.0 -0.1 2.4
Ever had bowel cancer screening 0.4 0.4 0.5 0.7 -0.6
Diabetes diagnosed by doctor 0.0 0.1 0.1 0.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 1.9 -0.4 1.4
Friendships satisfaction 1.3 1.7 1.9 -1.4 1.2
Qualifications: nursing, teaching 0.0 0.1 0.1 0.3 -0.2
Commuting to job workplace: Walk 1.9 2.0 3.4 -0.8 1.8
Eye problems/disorders: Cataract 1.0 1.2 2.3 -0.2 1.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.5 -1.6 0.6
Medication for cholesterol 0.0 0.0 0.1 -0.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.9 -1.4 -0.4
Back pain experienced in last month 1.4 2.1 3.8 0.6 -2.0
Mineral and other dietary supplements 2.4 3.2 6.1 2.5 -0.6
Breast cancer (self-reported) 0.3 0.3 0.6 0.2 0.8
Asthma (self-reported) 1.5 3.0 5.2 -0.9 2.3
Osteoporosis (self-reported) 0.0 0.0 0.0 0.0 -0.2
Osteoarthritis (self-reported) 1.7 2.2 3.8 -0.7 -2.0
Medication: Aspirin 0.9 1.1 2.1 1.4 0.4
Medication: Gliclazide 0.6 0.7 0.9 1.0 0.7
Illnesses of father: None of the above (group 1) 4.2 5.2 10.4 3.2 0.2
Smoking status: Current 0.1 0.2 0.4 0.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.5 -0.7 -1.6
Whole body water mass 0.2 1.1 2.1 -1.5 -0.2
Leg predicted mass (right) 0.0 0.2 0.3 -0.4 -0.6
Arm fat mass (left) 0.0 0.1 0.3 -0.5 -0.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.1 0.1 1.0
Average weekly champagne plus white wine intake 2.0 2.8 4.5 2.1 1.0
Miserableness 0.5 0.9 1.6 -0.5 1.2
Guilty feelings 0.2 0.2 0.3 -0.6 0.4
Wears glasses or contact lenses 1.4 1.6 3.1 0.1 1.8
Ever taken oral contraceptive pill 0.6 0.7 1.1 1.1 0.5
Hearing aid user 0.6 0.6 1.1 -0.5 -1.0
Mother’s age at death 0.2 0.3 0.6 -0.8 0.0
Financial situation satisfaction 0.8 1.0 1.2 1.1 1.0
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 -0.7 0.3
Commuting to job workplace: Public transport 3.0 3.5 5.2 -1.4 2.3
Eye problems/disorders: Glaucoma 1.3 1.6 2.6 1.6 -0.7
Medication: Blood pressure 0.4 0.7 1.0 -1.0 0.6
Pain type(s) experienced in last month: Hip pain 2.1 2.6 4.1 2.0 -1.0
Supplements: Fish oil (including cod liver oil) 1.6 2.1 4.0 -2.0 0.3
High cholesterol (Self-reported) 0.4 0.7 0.7 0.8 0.9
Medication: Bendroflumethiazide 0.8 1.3 1.9 -0.8 1.4
Medication: Paracetamol 1.0 1.5 2.3 1.5 0.8
Medication: Lisinopril 0.9 1.2 2.4 0.1 1.6
Medication: Atorvastatin 0.3 0.3 0.7 0.8 0.2
Illnesses of father: High blood pressure 3.0 3.7 7.3 -2.7 -0.2
Alcohol drinker status: Never 0.0 0.0 0.1 -0.2 0.1
Ever smoked 0.6 1.1 1.5 1.2 0.9
Basal metabolic rate 0.2 0.9 1.6 -1.3 -0.3
Leg fat percentage (left) 0.1 0.5 1.0 -1.0 -0.2
Arm fat-free mass (left) 0.3 1.4 2.6 -1.6 0.5
Number of operations (self-reported) 0.2 0.3 0.5 -0.4 -0.7
Average weekly beer plus cider intake 0.7 1.0 1.9 -1.4 -0.3
Irritability 0.3 0.6 1.1 0.2 -1.1
Risk taking 1.0 1.5 1.7 1.3 -1.2
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.5 -1.6 0.3
Fractured/broken bones in last 5 years 1.0 1.3 2.0 1.4 -0.8
Age started oral contraceptive pill 0.9 1.1 1.3 1.0 1.1
Diastolic blood pressure, automated reading 0.9 2.8 4.1 -2.0 1.2
Ever depressed for a whole week 0.0 0.1 0.1 0.1 0.3
Unable to work because of sickness or disability 0.8 1.0 1.6 1.3 -0.6
Commuting to job workplace: Cycle 0.5 0.6 1.0 -0.4 1.0
Myopia 0.7 1.0 1.9 1.4 0.3
Vascular/heart problems diagnosed by doctor 1.3 3.5 4.7 2.2 -1.5
Cholesterol lowering medication 0.2 0.3 0.5 0.7 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 2.6 -1.6 0.7
Pain experienced in last month 0.8 1.3 1.8 -0.9 1.3
Supplements: Calcium 0.8 0.9 1.7 -0.2 1.3
Basal cell carcinoma (self-reported) 1.0 1.2 1.8 -1.4 0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.7 1.4 1.2 -0.0
Deep venous thrombosis (DVT) (self-reported) 2.6 3.4 6.0 2.5 -0.9
Heart disease (siblings) 1.4 1.8 3.4 0.3 1.9
Alcohol drinker status: Previous 0.3 0.3 0.7 0.1 -0.8
Pack years of smoking 1.1 1.6 2.8 -1.7 -0.7
Impedance of whole body 0.4 2.2 4.1 2.0 -0.6
Leg fat mass (left) 0.1 0.5 0.9 -0.9 -0.3
Arm predicted mass (left) 0.2 1.0 1.8 -1.3 0.3