Hub : Genes

SNX22

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Squamous Cell Carcinoma	0.0422	0.0243	4.1e-03	0.031	0.030	0.029	NA	0.029	1.7e-04	2.0e-04	3.0e-04	NA	2.9e-04
2	TCGA	Stomach Adenocarcinoma	0.1520	0.0810	1.3e-03	0.055	0.036	0.057	NA	0.045	8.0e-05	1.2e-03	5.4e-05	NA	3.2e-04
3	TCGA	Thyroid Carcinoma	0.0500	0.0270	2.1e-06	0.072	0.061	0.054	NA	0.060	1.4e-07	1.3e-06	5.5e-06	NA	1.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.5	2.3	5.2	-2.3	-0.5	-1.2
Bipolar Disorder or Schizophrenia	1.3	3.3	8.9	-3.0	0.2	0.9
Depressed Affect (Nagel 2018)	0.8	1.7	2.3	-1.3	1.1	-1.5
Depression (Nagel 2018)	0.5	0.8	2.1	-0.3	0.3	-1.5
Intelligence (Savage-Jansen 2018)	0.9	2.6	5.2	-0.4	2.3	-1.6
Neuroticism (Nagel 2018)	0.6	1.4	2.3	-1.5	1.2	-0.7
Schizophrenia (2018)	1.5	3.0	4.7	-2.0	0.6	2.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.0	-0.3	0.0	1.7
Worry (Nagel 2018)	0.9	1.8	2.3	-1.3	1.5	1.2
Alzheimer’s Disease (in mother)	2.1	2.4	4.0	1.4	1.1	2.0
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-0.8	0.3	1.2
Alzheimer’s Disease (including proxy)	3.7	5.3	12.3	-0.0	1.9	3.5
Crohns Disease (2017)	0.6	1.2	2.6	0.6	0.9	-1.6
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	-0.1	1.2	-1.1
Ulcerative Colitis (UC)	0.4	0.8	1.8	-0.7	1.3	0.0
Major Depression (MDD)	1.1	1.3	3.6	0.3	-1.9	-0.5
Reaction Time	0.1	0.1	0.3	-0.5	-0.2	0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.2	-0.7	1.8	-0.5
Breast Cancer	2.3	5.6	14.7	0.2	1.4	3.8
Ovarian Cancer	0.1	0.1	0.3	0.2	-0.1	0.6
Prostate Cancer	1.6	2.3	4.6	-1.2	-0.8	-2.2
Age at First Birth	0.6	0.8	1.3	0.5	1.0	-1.1
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.0	0.0	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-1.0	0.1	0.6
Coronary Artery Disease (CAD)	1.9	2.2	5.1	2.2	0.5	-1.2
Crohns Disease (2012)	0.7	1.2	2.8	1.7	0.0	-0.8
Mean Putamen Volume	3.5	4.0	9.5	-3.1	-0.3	1.5
Fasting Glucose	0.4	0.5	1.0	0.5	-0.5	1.0
HbA1C	1.2	1.4	2.2	0.4	1.3	1.5
HDL Cholesterol	0.3	0.5	0.8	-0.8	-0.4	0.9
LDL Cholesterol	1.1	1.8	3.1	1.2	1.8	-0.8
Lupus	0.5	0.7	1.1	-0.6	0.9	1.0
Neuroticism (2016)	0.4	0.5	0.9	-0.4	0.7	-1.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.8	0.2	-0.1
Rheumatoid Arthritis	1.0	1.4	3.8	-0.2	2.0	0.5
Schizophrenia (2014)	1.6	3.4	5.6	-2.4	0.9	2.0
Triglycerides	0.8	1.4	3.3	1.8	-0.8	0.3
Type 2 Diabetes (T2D) (2012)	4.9	5.6	8.3	2.9	2.4	1.6
Ulcerative Colitis	0.1	0.2	0.6	0.0	0.3	-0.8
Blood Eosinophil Count	0.1	0.7	1.9	0.1	0.4	-1.4
Blood Platelet Count	0.8	8.8	12.1	3.5	-1.6	3.4
Blood Red Count	1.4	13.2	38.8	-6.2	-0.2	-0.9
Blood White Count	4.9	36.4	60.5	7.8	-0.8	-6.9
Heel T-Score	0.4	2.9	8.4	-0.1	-2.9	-0.5
BMI	0.5	3.1	5.8	-2.4	-0.4	-1.8
Height	0.2	3.0	5.5	-1.9	-0.2	2.4
Waist Hip Ratio (WHR)	0.2	0.9	2.2	1.5	0.3	0.6
Systolic Blood Pressure	0.5	2.6	4.6	-2.1	1.0	1.5
Smoking Status	0.2	0.5	1.1	0.7	-0.1	-1.0
Allergy or Eczema	0.4	0.9	2.5	-1.6	-0.6	-0.0
Cardiovascular Disease	0.8	2.6	6.0	-2.4	0.1	-1.4
Hypothyroidism (self reported)	2.2	5.0	12.8	-1.0	-1.1	-3.6
Respiratory disease	0.7	1.5	2.4	-0.6	1.4	1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	-0.2	-1.1	-0.4
Lung FEV1/FVC ratio	0.1	0.5	0.6	0.6	0.8	0.6
Lung FVC	0.1	0.5	1.0	-0.6	-1.0	-0.5
Neuroticism	0.2	0.5	1.2	-0.6	0.1	-1.1
Chronotype (morning person)	1.6	3.8	4.6	1.5	2.2	2.1
Hair Pigment	0.2	7.0	12.9	0.2	-2.8	-3.6
Tanning	0.1	1.2	2.2	-1.5	-1.0	0.8
Hand grip strength (left)	0.6	1.5	2.4	-1.6	0.3	1.4
Number of treatments/medications taken	0.7	1.3	3.4	-0.7	1.8	-0.3
Average weekly spirits intake	0.0	0.0	0.1	-0.1	-0.2	0.1
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.8	-0.0	-0.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.7	0.5	0.8	-1.3
Hearing difficulty/problems: Yes	0.8	1.2	2.6	0.9	0.2	-1.6
Relative age of first facial hair	0.4	0.8	1.8	-0.0	-1.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.2	1.1	-0.5	-1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	0.2	0.7	0.3
Ever had hysterectomy (womb removed)	1.2	1.3	1.6	1.0	-1.2	-1.2
Systolic blood pressure, automated reading	1.3	3.7	10.1	-3.2	0.7	0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.8	0.4	-1.2	-1.4
Angina	2.7	3.5	4.9	2.2	-1.5	-1.8
Medication for hormone replacement therapy	0.4	0.4	1.1	-0.0	0.4	1.1
Vitamin and mineral supplements	9.9	13.4	27.2	0.9	-3.5	-5.2
Supplements: Zinc	1.0	1.1	1.6	0.5	1.3	1.2
Medication: Co-codamol	1.5	1.8	2.3	-0.9	-1.5	-1.5
Medication: Metformin	0.7	0.9	2.6	-0.3	-1.6	-0.2
Diabetes (father)	1.2	1.4	2.9	-0.1	-1.2	1.7
Diabetes (mother)	0.1	0.1	0.4	-0.1	-0.0	0.6
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.4	-0.1
Pack years adult smoking proportion	1.0	1.5	3.9	-2.0	0.7	0.5
Impedance of leg (right)	0.1	0.4	0.6	0.6	0.5	0.8
Leg fat-free mass (left)	0.2	1.0	1.5	-0.9	-1.2	-0.7
Trunk fat percentage	1.8	7.0	16.8	-0.7	-1.9	-4.1
Hand grip strength (right)	0.4	1.0	2.5	-1.6	0.6	0.4
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.6	0.7	0.4
Current tobacco smoking	0.6	0.9	2.3	0.0	-0.6	-1.5
Average weekly fortified wine intake	0.0	0.0	0.1	0.1	0.2	-0.2
Maternal smoking around birth	0.7	1.1	2.3	-1.5	-0.9	-0.3
Fed-up feelings	0.6	1.1	1.6	-0.7	1.1	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	-0.7	-0.5	-1.4
Relative age voice broke	0.4	0.6	1.4	-0.5	0.3	1.2
Taking other prescription medications	0.2	0.2	0.4	-0.5	0.7	0.3
Age when periods started (menarche)	2.5	6.1	13.5	3.7	0.3	2.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	-0.1	-0.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.2	-2.0	-0.9	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.6	-1.3	0.0	-0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.6	0.2	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	1.1	-0.1	0.7
High blood pressure	1.4	3.8	8.5	-2.9	-0.2	-1.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.3	-1.5	0.3	0.2
Multivitamins +/- minerals	7.7	9.8	17.2	-1.9	2.9	4.1
Stomach or abdominal pain in last month	1.3	1.6	4.2	2.0	0.9	0.0
Supplements: Glucosamine	0.5	0.6	1.6	-1.2	-0.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.9	-0.3	0.2
Medication: Atenolol	1.6	2.1	6.1	0.3	-0.1	-2.5
Medication: Levothyroxine sodium	0.3	0.5	1.0	-1.0	-0.1	-0.7
Sitting height	0.2	1.3	2.2	1.3	-0.3	1.5
Chronic bronchitis/emphysema (father)	0.5	0.6	0.9	-0.9	0.1	0.9
High blood pressure (mother)	0.2	0.3	0.7	0.2	0.8	-0.5
Body mass index (BMI)	1.1	4.6	7.2	-2.0	-1.5	-2.7
Impedance of leg (left)	0.1	0.5	1.1	1.1	0.6	0.3
Leg predicted mass (left)	0.2	0.9	1.4	-0.9	-1.2	-0.7
Trunk fat mass	1.2	5.3	11.5	-1.1	-1.8	-3.4
Waist circumference	0.8	3.1	7.4	-0.7	-1.2	-2.7
Number of incorrect matches in round	1.6	2.7	7.3	0.4	0.8	2.7
Past tobacco smoking	0.3	0.6	0.8	-0.8	-0.7	0.9
Alcohol usually taken with meals	0.3	0.5	1.0	1.0	0.0	-0.6
Nervous feelings	1.3	2.4	4.7	-1.3	0.9	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.6	1.3	-0.6
Hearing difficulty/problems with background noise	0.6	0.9	1.9	-1.4	0.9	0.2
Hair/balding pattern: Pattern 2	1.6	2.0	3.8	2.0	0.9	1.2
Had menopause	0.6	0.7	1.6	-1.3	-0.0	0.8
Had other major operations	2.1	2.6	4.2	-1.0	-1.6	-2.1
Forced vital capacity (FVC)	0.2	0.8	1.5	-1.2	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.6	-1.0	-1.2	0.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.1	1.4	1.2	0.8
Qualifications: None of the above	0.5	1.0	1.6	-0.0	-1.2	-1.3
Financial difficulties in last 2 years	2.0	2.7	5.1	-0.1	-1.7	-2.3
Mouth/teeth dental problems	0.6	0.9	2.5	0.2	1.6	-0.3
Heart attack	0.4	0.5	1.2	1.1	0.5	0.1
Allergy	0.5	1.1	1.5	1.2	-1.2	-0.7
Pain all over the body in last month	1.5	1.6	3.1	-0.5	1.1	1.8
Diabetes (self-reported)	0.9	1.4	3.3	0.2	-1.8	-0.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	0.4	0.6	0.0
Medication: Ramipril	0.2	0.2	0.4	-0.5	0.6	-0.0
Medication: Simvastatin	1.5	2.2	6.4	2.5	0.5	-0.2
Fluid intelligence score	0.4	0.9	1.7	-1.3	0.9	-0.5
Illnesses of siblings	0.4	0.6	1.5	1.2	0.4	0.1
Neuroticism score	0.3	0.6	1.2	-0.7	1.1	-0.4
Weight	0.6	2.8	3.8	-1.5	-1.4	-2.0
Impedance of arm (right)	0.3	1.5	3.6	1.9	-0.0	-0.9
Arm fat percentage (right)	1.2	4.9	9.9	-1.5	-1.6	-3.1
Trunk fat-free mass	0.3	1.5	2.4	-1.5	0.1	1.5
Hip circumference	0.8	3.4	7.3	-1.4	-0.9	-2.7
Time employed in main current job	0.7	0.8	1.7	-0.7	-0.5	1.3
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.1	-0.2	0.3
Father’s age at death	1.2	1.7	5.0	0.2	0.1	2.2
Worrier / anxious feelings	1.0	1.9	3.6	-0.4	1.4	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.8	1.3	0.3	-1.0
Falls in the last year	0.3	0.3	0.6	0.7	-0.7	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.2	-1.5	0.2	0.2
Number of live births	0.9	1.3	1.9	-1.4	-0.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	-0.4	-0.4	0.5
Pulse rate	0.4	0.7	1.8	0.5	1.3	-0.2
Happiness	0.9	1.1	2.5	0.4	0.8	-1.6
Noisy workplace	0.9	1.2	2.4	-1.5	1.0	0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.4	-1.1	1.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.5	-0.6	0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	1.4	-0.4	-1.0
Asthma	1.2	2.3	4.1	-0.5	2.0	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.6	0.2	-0.0	-2.4
Medication: Cholesterol lowering	0.6	0.9	2.8	1.7	0.1	-0.0
Depression (self-reported)	0.3	0.3	0.8	-0.9	0.1	-0.4
Medication: Lansoprazole	1.4	1.6	3.8	-2.0	0.9	-0.0
Prospective memory result	0.7	0.8	1.4	-0.8	-0.6	1.2
Lung cancer (father)	4.5	5.2	7.8	1.1	-2.6	-2.8
Illnesses of mother	0.2	0.2	0.4	-0.4	0.6	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.5	0.3	-0.1	1.2
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	0.9	-0.4	-1.9
Impedance of arm (left)	0.4	1.7	3.3	1.8	-0.5	-1.2
Arm fat mass (right)	1.1	4.3	8.3	-1.5	-1.6	-2.9
Trunk predicted mass	0.2	1.4	2.2	-1.5	0.1	1.4
Standing height	0.1	0.6	1.3	0.7	-0.1	1.2
Length of working week for main job	1.5	1.7	3.4	1.1	0.7	1.8
Exposure to tobacco smoke at home	1.5	1.7	2.6	-1.6	1.5	0.4
Breastfed as a baby	1.1	1.3	1.6	-1.3	-1.1	1.0
Tense / ‘highly strung’	0.6	0.9	1.7	-0.9	1.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.8	-2.4	1.0	1.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	-0.1	0.9	0.7
Birth weight of first child	0.6	1.2	2.7	0.8	-1.6	0.4
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.4	0.5	0.6
Pulse wave reflection index	0.4	0.5	0.6	0.5	-0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	0.0	0.0	-1.3
Loud music exposure frequency	0.9	1.0	1.9	0.9	1.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.2	-1.1	-1.0	-0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.7	-0.7	-1.9	0.8
Blood clot in the leg (DVT)	4.5	5.8	13.4	1.1	-1.7	-3.7
Medication: Paracetamol	0.9	1.5	4.0	0.7	-0.0	-2.0
Headache pain in last month	1.0	1.8	2.3	1.4	1.1	-1.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.8	-0.3	0.1
Glaucoma (self-reported)	1.6	1.9	4.8	2.2	0.4	0.9
Gout (self-reported)	0.5	0.7	1.4	1.2	-0.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.6	-0.5	-0.1	-2.1
Medication: Amlodipine	0.5	0.7	1.2	-1.1	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.8	-0.3	0.1
Birth weight	0.6	1.4	2.4	0.7	-1.5	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	-0.1	-0.7	-0.7
High blood pressure (siblings)	0.2	0.3	0.8	-0.9	0.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.4	-0.4	0.8
Body fat percentage	1.5	6.0	13.2	-1.4	-1.7	-3.6
Leg fat percentage (right)	1.3	4.6	6.8	-2.2	-1.6	-2.6
Arm fat-free mass (right)	0.1	0.7	1.7	-1.3	-0.7	-0.1
Exposure to tobacco smoke outside home	0.5	0.7	1.5	1.2	0.6	0.5
Comparative body size at age 10	1.8	4.9	14.3	0.3	-0.5	-3.8
Number of full brothers	1.3	1.6	2.4	0.0	1.6	1.5
Worry too long after embarrassment	0.2	0.4	0.7	0.1	0.8	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.4	-1.8	0.2	-0.3
Wheeze or whistling in the chest in last year	1.8	3.3	4.8	-1.7	1.4	2.2
Number of children fathered	1.4	1.5	2.6	1.6	0.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	6.5	7.6	15.9	0.5	4.0	2.5
Age at first live birth	0.4	0.8	1.3	-0.0	1.1	1.0
Pulse wave peak to peak time	1.5	1.7	4.3	-0.8	0.5	2.1
Health satisfaction	0.5	0.6	1.2	-0.7	0.4	1.1
Shortness of breath walking on level ground	1.4	1.7	3.8	-0.3	-1.9	-1.1
Qualifications: College or University degree	1.2	3.7	4.3	-2.1	1.7	2.0
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.0	0.1	0.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	5.3	-0.3	-2.3	-1.3
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.3	0.4	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	-0.3	-0.8	0.8
Neck or shoulder pain in last month	0.3	0.4	0.8	0.9	-0.1	0.7
Medication: Blood pressure	0.3	0.5	1.6	0.0	0.1	-1.2
Angina (self-reported)	2.4	3.2	4.4	2.1	-1.6	-1.6
Migraine (self-reported)	1.2	1.5	2.2	-1.3	0.6	-1.5
Medication: Ibuprofen	1.3	1.5	4.5	0.2	0.2	-2.1
Medication: Allopurinol	0.2	0.3	0.6	0.7	-0.3	0.6
Medication: Omeprazole	0.2	0.3	0.6	-0.4	0.8	-0.2
Medication: Seretide 50 evohaler	0.7	0.8	1.4	0.3	1.2	1.0
Mean time to correctly identify matches	0.1	0.3	0.6	-0.8	0.3	0.3
Heart disease (mother)	0.2	0.3	0.4	-0.4	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	0.4	1.2	-0.0
Whole body fat mass	1.0	4.3	8.3	-1.6	-1.5	-2.9
Leg fat mass (right)	1.0	3.9	5.3	-2.0	-1.6	-2.3
Arm predicted mass (right)	0.1	0.7	1.5	-1.2	-0.7	-0.1
Pulse rate, automated reading	0.3	0.9	2.2	1.5	0.7	-0.3
Alcohol intake frequency.	0.4	0.9	1.9	-1.4	-0.4	0.7
Comparative height size at age 10	0.1	0.4	0.7	-0.6	-0.3	0.8
Number of full sisters	0.3	0.3	0.8	0.2	-0.5	0.9
Suffer from ‘nerves’	1.6	2.5	5.3	-1.2	2.3	0.8
Overall health rating	1.0	2.2	4.5	0.9	1.1	-2.1
Chest pain or discomfort	0.3	0.5	0.9	-0.8	-0.1	-0.9
Had major operations	1.0	1.2	2.2	1.1	-0.5	1.5
Age at last live birth	0.5	0.8	1.6	-0.0	0.8	1.3
Family relationship satisfaction	0.6	0.8	2.3	-0.0	1.5	-0.2
Leg pain on walking	0.6	0.7	1.9	1.4	0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	0.7	0.9	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.9	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-1.0	1.3	-0.1
Medication: Aspirin	0.4	0.5	1.2	1.1	0.2	-0.6
Supplements: Vitamin C	3.0	3.5	7.6	0.8	1.5	2.8
Knee pain experienced in last month	0.0	0.1	0.1	-0.2	-0.2	-0.3
Hypertension (Self-reported)	1.5	4.2	7.7	-2.8	-0.1	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	5.3	-0.4	2.3	0.1
Illnesses of father: Heart disease	0.2	0.3	0.4	-0.6	-0.6	0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.5	-0.5	0.7	1.6
Smoking status: Previous	0.4	0.5	0.8	0.9	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.1	0.1	-2.0	-0.5
Whole body fat-free mass	0.1	0.7	1.7	-1.3	-0.5	0.5
Leg fat-free mass (right)	0.2	0.9	1.5	-0.7	-1.2	-0.9
Arm fat percentage (left)	1.6	6.3	12.7	-1.5	-2.0	-3.6
Average weekly red wine intake	1.2	1.7	3.9	0.5	1.0	2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	0.3	-0.3	-1.3
Mood swings	1.4	2.5	3.9	-1.6	-1.0	-2.0
Loneliness, isolation	1.5	2.1	3.1	-1.8	1.3	-1.2
Long-standing illness, disability or infirmity	0.9	1.4	3.8	0.6	1.9	0.4
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	-0.3	-0.1
Diabetes diagnosed by doctor	0.7	1.1	2.1	-0.2	-1.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.3	-0.5	-0.5	-1.1
Friendships satisfaction	1.0	1.2	2.2	-1.5	1.1	-0.5
Qualifications: nursing, teaching	0.9	1.4	3.3	0.7	0.7	1.8
Commuting to job workplace: Walk	1.2	1.3	2.2	0.1	1.3	1.5
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.1	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.1	-1.0	0.6	1.8
Medication for cholesterol	1.1	1.7	4.5	0.6	0.6	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.9	-1.4	0.3	0.7
Back pain experienced in last month	0.4	0.6	1.0	0.5	-1.0	0.8
Mineral and other dietary supplements	3.0	4.0	7.7	1.7	-1.2	-2.8
Breast cancer (self-reported)	0.2	0.2	0.6	0.3	-0.0	-0.8
Asthma (self-reported)	0.9	1.9	3.6	-0.3	1.9	1.4
Osteoporosis (self-reported)	0.4	0.6	1.0	0.2	0.8	1.0
Osteoarthritis (self-reported)	1.2	1.6	3.1	-1.2	-1.8	-0.4
Medication: Aspirin	0.8	1.0	2.1	1.4	0.5	-0.8
Medication: Gliclazide	0.3	0.3	0.7	0.8	0.1	-0.6
Illnesses of father: None of the above (group 1)	4.1	5.1	8.0	2.7	-0.3	-2.8
Smoking status: Current	0.3	0.4	1.0	-0.3	-0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	-1.0	-1.3	0.2
Whole body water mass	0.1	0.7	1.7	-1.3	-0.5	0.4
Leg predicted mass (right)	0.2	1.0	1.6	-0.7	-1.3	-0.9
Arm fat mass (left)	0.9	3.9	7.5	-1.4	-1.5	-2.7
Number of self-reported non-cancer illnesses	0.7	1.3	3.4	-0.3	0.6	-1.8
Average weekly champagne plus white wine intake	2.1	2.9	6.7	2.6	1.3	0.5
Miserableness	0.4	0.7	1.6	-0.4	1.3	-0.5
Guilty feelings	0.1	0.1	0.2	-0.5	0.1	-0.2
Wears glasses or contact lenses	1.9	2.2	6.1	0.2	2.5	-0.6
Ever taken oral contraceptive pill	0.6	0.6	1.3	1.1	0.7	-0.2
Hearing aid user	0.3	0.4	0.7	-0.8	-0.6	-0.3
Mother’s age at death	0.6	0.8	2.3	-0.2	0.2	1.5
Financial situation satisfaction	1.6	2.0	3.2	1.8	1.3	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	-0.1	0.8	1.4
Commuting to job workplace: Public transport	0.9	1.1	2.2	-0.7	1.5	0.8
Eye problems/disorders: Glaucoma	0.9	1.1	3.2	1.8	-0.1	0.3
Medication: Blood pressure	1.5	2.9	5.7	-1.7	-0.3	-2.4
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.3	1.2	-1.2	-2.1
Supplements: Fish oil (including cod liver oil)	2.1	2.7	5.2	-1.3	1.1	2.3
High cholesterol (Self-reported)	0.6	1.1	2.1	1.0	1.5	0.2
Medication: Bendroflumethiazide	1.1	1.7	3.8	-1.2	-0.0	-1.9
Medication: Paracetamol	1.1	1.8	3.6	1.3	0.2	-1.9
Medication: Lisinopril	0.5	0.6	1.4	0.3	0.6	-1.2
Medication: Atorvastatin	4.0	5.0	11.3	-0.2	-1.9	-3.4
Illnesses of father: High blood pressure	1.9	2.3	4.0	-2.0	0.3	1.7
Alcohol drinker status: Never	0.4	0.5	1.0	0.0	0.6	1.0
Ever smoked	0.6	1.1	1.2	1.1	1.0	-1.1
Basal metabolic rate	0.1	0.8	1.7	-1.3	-0.8	-0.1
Leg fat percentage (left)	1.2	4.4	7.1	-2.0	-1.5	-2.7
Arm fat-free mass (left)	0.1	0.6	1.7	-1.3	0.0	0.5
Number of operations (self-reported)	0.1	0.2	0.4	-0.6	-0.5	-0.1
Average weekly beer plus cider intake	0.6	0.9	1.7	-1.1	0.1	1.3
Irritability	0.1	0.2	0.3	-0.1	-0.3	-0.6
Risk taking	1.1	1.5	2.2	1.5	-0.7	1.4
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.5	-1.1	1.0	1.2
Fractured/broken bones in last 5 years	0.9	1.1	2.6	1.6	-0.3	0.8
Age started oral contraceptive pill	0.6	0.7	1.2	1.1	1.0	-0.2
Diastolic blood pressure, automated reading	0.7	2.2	4.9	-2.2	-0.1	-1.2
Ever depressed for a whole week	2.8	3.4	5.4	0.9	2.0	2.3
Unable to work because of sickness or disability	1.2	1.6	3.3	0.8	-0.9	-1.8
Commuting to job workplace: Cycle	1.1	1.3	2.2	-0.8	-1.0	-1.5
Myopia	0.9	1.3	2.9	0.9	-0.3	-1.7
Vascular/heart problems diagnosed by doctor	1.0	2.8	5.3	2.3	0.3	1.7
Cholesterol lowering medication	1.0	1.5	3.5	0.0	-1.0	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.0	-1.7	0.2	-0.1
Pain experienced in last month	0.7	1.1	2.4	-0.6	1.6	0.8
Supplements: Calcium	6.6	7.3	14.2	1.2	2.5	3.8
Basal cell carcinoma (self-reported)	1.3	1.5	2.0	-1.1	1.1	1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	1.2	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	5.2	6.7	15.2	1.2	-1.9	-3.9
Heart disease (siblings)	0.4	0.5	1.3	0.4	1.2	-0.3
Alcohol drinker status: Previous	0.3	0.4	1.0	0.1	-1.0	0.4
Pack years of smoking	0.9	1.3	3.1	-1.8	0.7	0.6
Impedance of whole body	0.2	1.2	3.0	1.7	0.1	-0.7
Leg fat mass (left)	0.9	3.6	5.6	-1.8	-1.5	-2.4
Arm predicted mass (left)	0.1	0.4	1.1	-1.1	-0.0	0.4