Hub : Genes

SNX22

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Lung Squamous Cell Carcinoma 0.0422 0.0243 4.1e-03 0.031 0.030 0.029 NA 0.029 1.7e-04 2.0e-04 3.0e-04 NA 2.9e-04
2 TCGA Stomach Adenocarcinoma 0.1520 0.0810 1.3e-03 0.055 0.036 0.057 NA 0.045 8.0e-05 1.2e-03 5.4e-05 NA 3.2e-04
3 TCGA Thyroid Carcinoma 0.0500 0.0270 2.1e-06 0.072 0.061 0.054 NA 0.060 1.4e-07 1.3e-06 5.5e-06 NA 1.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.5 2.3 5.2 -2.3 -0.5 -1.2
Bipolar Disorder or Schizophrenia 1.3 3.3 8.9 -3.0 0.2 0.9
Depressed Affect (Nagel 2018) 0.8 1.7 2.3 -1.3 1.1 -1.5
Depression (Nagel 2018) 0.5 0.8 2.1 -0.3 0.3 -1.5
Intelligence (Savage-Jansen 2018) 0.9 2.6 5.2 -0.4 2.3 -1.6
Neuroticism (Nagel 2018) 0.6 1.4 2.3 -1.5 1.2 -0.7
Schizophrenia (2018) 1.5 3.0 4.7 -2.0 0.6 2.2
Schizophrenia vs Biploar Disorder 0.8 1.0 3.0 -0.3 0.0 1.7
Worry (Nagel 2018) 0.9 1.8 2.3 -1.3 1.5 1.2
Alzheimer’s Disease (in mother) 2.1 2.4 4.0 1.4 1.1 2.0
Alzheimer’s Disease (in father) 0.7 0.7 1.5 -0.8 0.3 1.2
Alzheimer’s Disease (including proxy) 3.7 5.3 12.3 -0.0 1.9 3.5
Crohns Disease (2017) 0.6 1.2 2.6 0.6 0.9 -1.6
Irritable Bowel Disease (IBD) 0.4 1.0 1.6 -0.1 1.2 -1.1
Ulcerative Colitis (UC) 0.4 0.8 1.8 -0.7 1.3 0.0
Major Depression (MDD) 1.1 1.3 3.6 0.3 -1.9 -0.5
Reaction Time 0.1 0.1 0.3 -0.5 -0.2 0.0
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.2 -0.7 1.8 -0.5
Breast Cancer 2.3 5.6 14.7 0.2 1.4 3.8
Ovarian Cancer 0.1 0.1 0.3 0.2 -0.1 0.6
Prostate Cancer 1.6 2.3 4.6 -1.2 -0.8 -2.2
Age at First Birth 0.6 0.8 1.3 0.5 1.0 -1.1
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.0 0.0 0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -1.0 0.1 0.6
Coronary Artery Disease (CAD) 1.9 2.2 5.1 2.2 0.5 -1.2
Crohns Disease (2012) 0.7 1.2 2.8 1.7 0.0 -0.8
Mean Putamen Volume 3.5 4.0 9.5 -3.1 -0.3 1.5
Fasting Glucose 0.4 0.5 1.0 0.5 -0.5 1.0
HbA1C 1.2 1.4 2.2 0.4 1.3 1.5
HDL Cholesterol 0.3 0.5 0.8 -0.8 -0.4 0.9
LDL Cholesterol 1.1 1.8 3.1 1.2 1.8 -0.8
Lupus 0.5 0.7 1.1 -0.6 0.9 1.0
Neuroticism (2016) 0.4 0.5 0.9 -0.4 0.7 -1.0
Primary Biliary Cirrhosis 0.2 0.3 0.7 -0.8 0.2 -0.1
Rheumatoid Arthritis 1.0 1.4 3.8 -0.2 2.0 0.5
Schizophrenia (2014) 1.6 3.4 5.6 -2.4 0.9 2.0
Triglycerides 0.8 1.4 3.3 1.8 -0.8 0.3
Type 2 Diabetes (T2D) (2012) 4.9 5.6 8.3 2.9 2.4 1.6
Ulcerative Colitis 0.1 0.2 0.6 0.0 0.3 -0.8
Blood Eosinophil Count 0.1 0.7 1.9 0.1 0.4 -1.4
Blood Platelet Count 0.8 8.8 12.1 3.5 -1.6 3.4
Blood Red Count 1.4 13.2 38.8 -6.2 -0.2 -0.9
Blood White Count 4.9 36.4 60.5 7.8 -0.8 -6.9
Heel T-Score 0.4 2.9 8.4 -0.1 -2.9 -0.5
BMI 0.5 3.1 5.8 -2.4 -0.4 -1.8
Height 0.2 3.0 5.5 -1.9 -0.2 2.4
Waist Hip Ratio (WHR) 0.2 0.9 2.2 1.5 0.3 0.6
Systolic Blood Pressure 0.5 2.6 4.6 -2.1 1.0 1.5
Smoking Status 0.2 0.5 1.1 0.7 -0.1 -1.0
Allergy or Eczema 0.4 0.9 2.5 -1.6 -0.6 -0.0
Cardiovascular Disease 0.8 2.6 6.0 -2.4 0.1 -1.4
Hypothyroidism (self reported) 2.2 5.0 12.8 -1.0 -1.1 -3.6
Respiratory disease 0.7 1.5 2.4 -0.6 1.4 1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.3 -0.2 -1.1 -0.4
Lung FEV1/FVC ratio 0.1 0.5 0.6 0.6 0.8 0.6
Lung FVC 0.1 0.5 1.0 -0.6 -1.0 -0.5
Neuroticism 0.2 0.5 1.2 -0.6 0.1 -1.1
Chronotype (morning person) 1.6 3.8 4.6 1.5 2.2 2.1
Hair Pigment 0.2 7.0 12.9 0.2 -2.8 -3.6
Tanning 0.1 1.2 2.2 -1.5 -1.0 0.8
Hand grip strength (left) 0.6 1.5 2.4 -1.6 0.3 1.4
Number of treatments/medications taken 0.7 1.3 3.4 -0.7 1.8 -0.3
Average weekly spirits intake 0.0 0.0 0.1 -0.1 -0.2 0.1
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.8 -0.0 -0.4
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.7 0.5 0.8 -1.3
Hearing difficulty/problems: Yes 0.8 1.2 2.6 0.9 0.2 -1.6
Relative age of first facial hair 0.4 0.8 1.8 -0.0 -1.4 -0.8
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.2 1.1 -0.5 -1.1
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.5 0.2 0.7 0.3
Ever had hysterectomy (womb removed) 1.2 1.3 1.6 1.0 -1.2 -1.2
Systolic blood pressure, automated reading 1.3 3.7 10.1 -3.2 0.7 0.7
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 1.8 0.4 -1.2 -1.4
Angina 2.7 3.5 4.9 2.2 -1.5 -1.8
Medication for hormone replacement therapy 0.4 0.4 1.1 -0.0 0.4 1.1
Vitamin and mineral supplements 9.9 13.4 27.2 0.9 -3.5 -5.2
Supplements: Zinc 1.0 1.1 1.6 0.5 1.3 1.2
Medication: Co-codamol 1.5 1.8 2.3 -0.9 -1.5 -1.5
Medication: Metformin 0.7 0.9 2.6 -0.3 -1.6 -0.2
Diabetes (father) 1.2 1.4 2.9 -0.1 -1.2 1.7
Diabetes (mother) 0.1 0.1 0.4 -0.1 -0.0 0.6
Severe depression (siblings) 0.1 0.1 0.2 0.2 0.4 -0.1
Pack years adult smoking proportion 1.0 1.5 3.9 -2.0 0.7 0.5
Impedance of leg (right) 0.1 0.4 0.6 0.6 0.5 0.8
Leg fat-free mass (left) 0.2 1.0 1.5 -0.9 -1.2 -0.7
Trunk fat percentage 1.8 7.0 16.8 -0.7 -1.9 -4.1
Hand grip strength (right) 0.4 1.0 2.5 -1.6 0.6 0.4
Townsend deprivation index at recruitment 0.2 0.3 0.5 -0.6 0.7 0.4
Current tobacco smoking 0.6 0.9 2.3 0.0 -0.6 -1.5
Average weekly fortified wine intake 0.0 0.0 0.1 0.1 0.2 -0.2
Maternal smoking around birth 0.7 1.1 2.3 -1.5 -0.9 -0.3
Fed-up feelings 0.6 1.1 1.6 -0.7 1.1 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.0 -0.7 -0.5 -1.4
Relative age voice broke 0.4 0.6 1.4 -0.5 0.3 1.2
Taking other prescription medications 0.2 0.2 0.4 -0.5 0.7 0.3
Age when periods started (menarche) 2.5 6.1 13.5 3.7 0.3 2.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.7 -0.1 -0.6 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 4.2 -2.0 -0.9 0.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.6 -1.3 0.0 -0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.4 0.6 0.2 -0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.3 1.1 -0.1 0.7
High blood pressure 1.4 3.8 8.5 -2.9 -0.2 -1.7
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.3 -1.5 0.3 0.2
Multivitamins +/- minerals 7.7 9.8 17.2 -1.9 2.9 4.1
Stomach or abdominal pain in last month 1.3 1.6 4.2 2.0 0.9 0.0
Supplements: Glucosamine 0.5 0.6 1.6 -1.2 -0.2 0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.9 -0.9 -0.3 0.2
Medication: Atenolol 1.6 2.1 6.1 0.3 -0.1 -2.5
Medication: Levothyroxine sodium 0.3 0.5 1.0 -1.0 -0.1 -0.7
Sitting height 0.2 1.3 2.2 1.3 -0.3 1.5
Chronic bronchitis/emphysema (father) 0.5 0.6 0.9 -0.9 0.1 0.9
High blood pressure (mother) 0.2 0.3 0.7 0.2 0.8 -0.5
Body mass index (BMI) 1.1 4.6 7.2 -2.0 -1.5 -2.7
Impedance of leg (left) 0.1 0.5 1.1 1.1 0.6 0.3
Leg predicted mass (left) 0.2 0.9 1.4 -0.9 -1.2 -0.7
Trunk fat mass 1.2 5.3 11.5 -1.1 -1.8 -3.4
Waist circumference 0.8 3.1 7.4 -0.7 -1.2 -2.7
Number of incorrect matches in round 1.6 2.7 7.3 0.4 0.8 2.7
Past tobacco smoking 0.3 0.6 0.8 -0.8 -0.7 0.9
Alcohol usually taken with meals 0.3 0.5 1.0 1.0 0.0 -0.6
Nervous feelings 1.3 2.4 4.7 -1.3 0.9 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.6 0.6 1.3 -0.6
Hearing difficulty/problems with background noise 0.6 0.9 1.9 -1.4 0.9 0.2
Hair/balding pattern: Pattern 2 1.6 2.0 3.8 2.0 0.9 1.2
Had menopause 0.6 0.7 1.6 -1.3 -0.0 0.8
Had other major operations 2.1 2.6 4.2 -1.0 -1.6 -2.1
Forced vital capacity (FVC) 0.2 0.8 1.5 -1.2 -0.8 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.6 -1.0 -1.2 0.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.1 1.4 1.2 0.8
Qualifications: None of the above 0.5 1.0 1.6 -0.0 -1.2 -1.3
Financial difficulties in last 2 years 2.0 2.7 5.1 -0.1 -1.7 -2.3
Mouth/teeth dental problems 0.6 0.9 2.5 0.2 1.6 -0.3
Heart attack 0.4 0.5 1.2 1.1 0.5 0.1
Allergy 0.5 1.1 1.5 1.2 -1.2 -0.7
Pain all over the body in last month 1.5 1.6 3.1 -0.5 1.1 1.8
Diabetes (self-reported) 0.9 1.4 3.3 0.2 -1.8 -0.9
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.4 0.4 0.6 0.0
Medication: Ramipril 0.2 0.2 0.4 -0.5 0.6 -0.0
Medication: Simvastatin 1.5 2.2 6.4 2.5 0.5 -0.2
Fluid intelligence score 0.4 0.9 1.7 -1.3 0.9 -0.5
Illnesses of siblings 0.4 0.6 1.5 1.2 0.4 0.1
Neuroticism score 0.3 0.6 1.2 -0.7 1.1 -0.4
Weight 0.6 2.8 3.8 -1.5 -1.4 -2.0
Impedance of arm (right) 0.3 1.5 3.6 1.9 -0.0 -0.9
Arm fat percentage (right) 1.2 4.9 9.9 -1.5 -1.6 -3.1
Trunk fat-free mass 0.3 1.5 2.4 -1.5 0.1 1.5
Hip circumference 0.8 3.4 7.3 -1.4 -0.9 -2.7
Time employed in main current job 0.7 0.8 1.7 -0.7 -0.5 1.3
Alcohol intake versus 10 years previously 0.0 0.0 0.1 0.1 -0.2 0.3
Father’s age at death 1.2 1.7 5.0 0.2 0.1 2.2
Worrier / anxious feelings 1.0 1.9 3.6 -0.4 1.4 1.9
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.8 1.3 0.3 -1.0
Falls in the last year 0.3 0.3 0.6 0.7 -0.7 -0.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.2 -1.5 0.2 0.2
Number of live births 0.9 1.3 1.9 -1.4 -0.3 1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.3 -0.4 -0.4 0.5
Pulse rate 0.4 0.7 1.8 0.5 1.3 -0.2
Happiness 0.9 1.1 2.5 0.4 0.8 -1.6
Noisy workplace 0.9 1.2 2.4 -1.5 1.0 0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.0 1.4 -1.1 1.2 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.3 -0.5 -0.6 0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 2.0 1.4 -0.4 -1.0
Asthma 1.2 2.3 4.1 -0.5 2.0 1.6
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 5.6 0.2 -0.0 -2.4
Medication: Cholesterol lowering 0.6 0.9 2.8 1.7 0.1 -0.0
Depression (self-reported) 0.3 0.3 0.8 -0.9 0.1 -0.4
Medication: Lansoprazole 1.4 1.6 3.8 -2.0 0.9 -0.0
Prospective memory result 0.7 0.8 1.4 -0.8 -0.6 1.2
Lung cancer (father) 4.5 5.2 7.8 1.1 -2.6 -2.8
Illnesses of mother 0.2 0.2 0.4 -0.4 0.6 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.5 0.3 -0.1 1.2
Pulse wave Arterial Stiffness index 1.4 1.6 3.8 0.9 -0.4 -1.9
Impedance of arm (left) 0.4 1.7 3.3 1.8 -0.5 -1.2
Arm fat mass (right) 1.1 4.3 8.3 -1.5 -1.6 -2.9
Trunk predicted mass 0.2 1.4 2.2 -1.5 0.1 1.4
Standing height 0.1 0.6 1.3 0.7 -0.1 1.2
Length of working week for main job 1.5 1.7 3.4 1.1 0.7 1.8
Exposure to tobacco smoke at home 1.5 1.7 2.6 -1.6 1.5 0.4
Breastfed as a baby 1.1 1.3 1.6 -1.3 -1.1 1.0
Tense / ‘highly strung’ 0.6 0.9 1.7 -0.9 1.3 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 5.8 -2.4 1.0 1.2
Hair/balding pattern: Pattern 4 0.2 0.4 0.8 -0.1 0.9 0.7
Birth weight of first child 0.6 1.2 2.7 0.8 -1.6 0.4
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.4 0.5 0.6
Pulse wave reflection index 0.4 0.5 0.6 0.5 -0.8 -0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.8 0.0 0.0 -1.3
Loud music exposure frequency 0.9 1.0 1.9 0.9 1.4 -0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.2 -1.1 -1.0 -0.5
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.7 -0.7 -1.9 0.8
Blood clot in the leg (DVT) 4.5 5.8 13.4 1.1 -1.7 -3.7
Medication: Paracetamol 0.9 1.5 4.0 0.7 -0.0 -2.0
Headache pain in last month 1.0 1.8 2.3 1.4 1.1 -1.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 -0.8 -0.3 0.1
Glaucoma (self-reported) 1.6 1.9 4.8 2.2 0.4 0.9
Gout (self-reported) 0.5 0.7 1.4 1.2 -0.8 -0.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.6 -0.5 -0.1 -2.1
Medication: Amlodipine 0.5 0.7 1.2 -1.1 -0.6 -0.8
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 -0.8 -0.3 0.1
Birth weight 0.6 1.4 2.4 0.7 -1.5 -1.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.6 -0.1 -0.7 -0.7
High blood pressure (siblings) 0.2 0.3 0.8 -0.9 0.1 0.2
Forced vital capacity (FVC), Best measure 0.1 0.3 0.6 -0.4 -0.4 0.8
Body fat percentage 1.5 6.0 13.2 -1.4 -1.7 -3.6
Leg fat percentage (right) 1.3 4.6 6.8 -2.2 -1.6 -2.6
Arm fat-free mass (right) 0.1 0.7 1.7 -1.3 -0.7 -0.1
Exposure to tobacco smoke outside home 0.5 0.7 1.5 1.2 0.6 0.5
Comparative body size at age 10 1.8 4.9 14.3 0.3 -0.5 -3.8
Number of full brothers 1.3 1.6 2.4 0.0 1.6 1.5
Worry too long after embarrassment 0.2 0.4 0.7 0.1 0.8 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.4 -1.8 0.2 -0.3
Wheeze or whistling in the chest in last year 1.8 3.3 4.8 -1.7 1.4 2.2
Number of children fathered 1.4 1.5 2.6 1.6 0.1 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 6.5 7.6 15.9 0.5 4.0 2.5
Age at first live birth 0.4 0.8 1.3 -0.0 1.1 1.0
Pulse wave peak to peak time 1.5 1.7 4.3 -0.8 0.5 2.1
Health satisfaction 0.5 0.6 1.2 -0.7 0.4 1.1
Shortness of breath walking on level ground 1.4 1.7 3.8 -0.3 -1.9 -1.1
Qualifications: College or University degree 1.2 3.7 4.3 -2.1 1.7 2.0
Eye problems/disorders: None of the above 0.1 0.1 0.4 0.0 0.1 0.6
Mouth/teeth dental problems: Loose teeth 2.0 2.4 5.3 -0.3 -2.3 -1.3
Emphysema/chronic bronchitis 0.3 0.3 0.7 -0.3 0.4 -0.9
Medication for pain relief, constipation, heartburn 0.3 0.5 0.7 -0.3 -0.8 0.8
Neck or shoulder pain in last month 0.3 0.4 0.8 0.9 -0.1 0.7
Medication: Blood pressure 0.3 0.5 1.6 0.0 0.1 -1.2
Angina (self-reported) 2.4 3.2 4.4 2.1 -1.6 -1.6
Migraine (self-reported) 1.2 1.5 2.2 -1.3 0.6 -1.5
Medication: Ibuprofen 1.3 1.5 4.5 0.2 0.2 -2.1
Medication: Allopurinol 0.2 0.3 0.6 0.7 -0.3 0.6
Medication: Omeprazole 0.2 0.3 0.6 -0.4 0.8 -0.2
Medication: Seretide 50 evohaler 0.7 0.8 1.4 0.3 1.2 1.0
Mean time to correctly identify matches 0.1 0.3 0.6 -0.8 0.3 0.3
Heart disease (mother) 0.2 0.3 0.4 -0.4 -0.7 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.4 0.4 1.2 -0.0
Whole body fat mass 1.0 4.3 8.3 -1.6 -1.5 -2.9
Leg fat mass (right) 1.0 3.9 5.3 -2.0 -1.6 -2.3
Arm predicted mass (right) 0.1 0.7 1.5 -1.2 -0.7 -0.1
Pulse rate, automated reading 0.3 0.9 2.2 1.5 0.7 -0.3
Alcohol intake frequency. 0.4 0.9 1.9 -1.4 -0.4 0.7
Comparative height size at age 10 0.1 0.4 0.7 -0.6 -0.3 0.8
Number of full sisters 0.3 0.3 0.8 0.2 -0.5 0.9
Suffer from ‘nerves’ 1.6 2.5 5.3 -1.2 2.3 0.8
Overall health rating 1.0 2.2 4.5 0.9 1.1 -2.1
Chest pain or discomfort 0.3 0.5 0.9 -0.8 -0.1 -0.9
Had major operations 1.0 1.2 2.2 1.1 -0.5 1.5
Age at last live birth 0.5 0.8 1.6 -0.0 0.8 1.3
Family relationship satisfaction 0.6 0.8 2.3 -0.0 1.5 -0.2
Leg pain on walking 0.6 0.7 1.9 1.4 0.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.8 0.7 0.9 0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.7 0.9 -0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.7 -1.0 1.3 -0.1
Medication: Aspirin 0.4 0.5 1.2 1.1 0.2 -0.6
Supplements: Vitamin C 3.0 3.5 7.6 0.8 1.5 2.8
Knee pain experienced in last month 0.0 0.1 0.1 -0.2 -0.2 -0.3
Hypertension (Self-reported) 1.5 4.2 7.7 -2.8 -0.1 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.8 5.3 -0.4 2.3 0.1
Illnesses of father: Heart disease 0.2 0.3 0.4 -0.6 -0.6 0.4
Illnesses of siblings: Diabetes 0.9 1.1 2.5 -0.5 0.7 1.6
Smoking status: Previous 0.4 0.5 0.8 0.9 0.5 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.1 0.1 -2.0 -0.5
Whole body fat-free mass 0.1 0.7 1.7 -1.3 -0.5 0.5
Leg fat-free mass (right) 0.2 0.9 1.5 -0.7 -1.2 -0.9
Arm fat percentage (left) 1.6 6.3 12.7 -1.5 -2.0 -3.6
Average weekly red wine intake 1.2 1.7 3.9 0.5 1.0 2.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 0.3 -0.3 -1.3
Mood swings 1.4 2.5 3.9 -1.6 -1.0 -2.0
Loneliness, isolation 1.5 2.1 3.1 -1.8 1.3 -1.2
Long-standing illness, disability or infirmity 0.9 1.4 3.8 0.6 1.9 0.4
Ever had bowel cancer screening 0.2 0.2 0.4 0.6 -0.3 -0.1
Diabetes diagnosed by doctor 0.7 1.1 2.1 -0.2 -1.1 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.3 -0.5 -0.5 -1.1
Friendships satisfaction 1.0 1.2 2.2 -1.5 1.1 -0.5
Qualifications: nursing, teaching 0.9 1.4 3.3 0.7 0.7 1.8
Commuting to job workplace: Walk 1.2 1.3 2.2 0.1 1.3 1.5
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.1 1.0 0.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.1 -1.0 0.6 1.8
Medication for cholesterol 1.1 1.7 4.5 0.6 0.6 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.9 -1.4 0.3 0.7
Back pain experienced in last month 0.4 0.6 1.0 0.5 -1.0 0.8
Mineral and other dietary supplements 3.0 4.0 7.7 1.7 -1.2 -2.8
Breast cancer (self-reported) 0.2 0.2 0.6 0.3 -0.0 -0.8
Asthma (self-reported) 0.9 1.9 3.6 -0.3 1.9 1.4
Osteoporosis (self-reported) 0.4 0.6 1.0 0.2 0.8 1.0
Osteoarthritis (self-reported) 1.2 1.6 3.1 -1.2 -1.8 -0.4
Medication: Aspirin 0.8 1.0 2.1 1.4 0.5 -0.8
Medication: Gliclazide 0.3 0.3 0.7 0.8 0.1 -0.6
Illnesses of father: None of the above (group 1) 4.1 5.1 8.0 2.7 -0.3 -2.8
Smoking status: Current 0.3 0.4 1.0 -0.3 -0.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -1.0 -1.3 0.2
Whole body water mass 0.1 0.7 1.7 -1.3 -0.5 0.4
Leg predicted mass (right) 0.2 1.0 1.6 -0.7 -1.3 -0.9
Arm fat mass (left) 0.9 3.9 7.5 -1.4 -1.5 -2.7
Number of self-reported non-cancer illnesses 0.7 1.3 3.4 -0.3 0.6 -1.8
Average weekly champagne plus white wine intake 2.1 2.9 6.7 2.6 1.3 0.5
Miserableness 0.4 0.7 1.6 -0.4 1.3 -0.5
Guilty feelings 0.1 0.1 0.2 -0.5 0.1 -0.2
Wears glasses or contact lenses 1.9 2.2 6.1 0.2 2.5 -0.6
Ever taken oral contraceptive pill 0.6 0.6 1.3 1.1 0.7 -0.2
Hearing aid user 0.3 0.4 0.7 -0.8 -0.6 -0.3
Mother’s age at death 0.6 0.8 2.3 -0.2 0.2 1.5
Financial situation satisfaction 1.6 2.0 3.2 1.8 1.3 1.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.1 -0.1 0.8 1.4
Commuting to job workplace: Public transport 0.9 1.1 2.2 -0.7 1.5 0.8
Eye problems/disorders: Glaucoma 0.9 1.1 3.2 1.8 -0.1 0.3
Medication: Blood pressure 1.5 2.9 5.7 -1.7 -0.3 -2.4
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.3 1.2 -1.2 -2.1
Supplements: Fish oil (including cod liver oil) 2.1 2.7 5.2 -1.3 1.1 2.3
High cholesterol (Self-reported) 0.6 1.1 2.1 1.0 1.5 0.2
Medication: Bendroflumethiazide 1.1 1.7 3.8 -1.2 -0.0 -1.9
Medication: Paracetamol 1.1 1.8 3.6 1.3 0.2 -1.9
Medication: Lisinopril 0.5 0.6 1.4 0.3 0.6 -1.2
Medication: Atorvastatin 4.0 5.0 11.3 -0.2 -1.9 -3.4
Illnesses of father: High blood pressure 1.9 2.3 4.0 -2.0 0.3 1.7
Alcohol drinker status: Never 0.4 0.5 1.0 0.0 0.6 1.0
Ever smoked 0.6 1.1 1.2 1.1 1.0 -1.1
Basal metabolic rate 0.1 0.8 1.7 -1.3 -0.8 -0.1
Leg fat percentage (left) 1.2 4.4 7.1 -2.0 -1.5 -2.7
Arm fat-free mass (left) 0.1 0.6 1.7 -1.3 0.0 0.5
Number of operations (self-reported) 0.1 0.2 0.4 -0.6 -0.5 -0.1
Average weekly beer plus cider intake 0.6 0.9 1.7 -1.1 0.1 1.3
Irritability 0.1 0.2 0.3 -0.1 -0.3 -0.6
Risk taking 1.1 1.5 2.2 1.5 -0.7 1.4
Ever had prostate specific antigen (PSA) test 1.0 1.2 1.5 -1.1 1.0 1.2
Fractured/broken bones in last 5 years 0.9 1.1 2.6 1.6 -0.3 0.8
Age started oral contraceptive pill 0.6 0.7 1.2 1.1 1.0 -0.2
Diastolic blood pressure, automated reading 0.7 2.2 4.9 -2.2 -0.1 -1.2
Ever depressed for a whole week 2.8 3.4 5.4 0.9 2.0 2.3
Unable to work because of sickness or disability 1.2 1.6 3.3 0.8 -0.9 -1.8
Commuting to job workplace: Cycle 1.1 1.3 2.2 -0.8 -1.0 -1.5
Myopia 0.9 1.3 2.9 0.9 -0.3 -1.7
Vascular/heart problems diagnosed by doctor 1.0 2.8 5.3 2.3 0.3 1.7
Cholesterol lowering medication 1.0 1.5 3.5 0.0 -1.0 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.0 -1.7 0.2 -0.1
Pain experienced in last month 0.7 1.1 2.4 -0.6 1.6 0.8
Supplements: Calcium 6.6 7.3 14.2 1.2 2.5 3.8
Basal cell carcinoma (self-reported) 1.3 1.5 2.0 -1.1 1.1 1.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 1.2 0.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 5.2 6.7 15.2 1.2 -1.9 -3.9
Heart disease (siblings) 0.4 0.5 1.3 0.4 1.2 -0.3
Alcohol drinker status: Previous 0.3 0.4 1.0 0.1 -1.0 0.4
Pack years of smoking 0.9 1.3 3.1 -1.8 0.7 0.6
Impedance of whole body 0.2 1.2 3.0 1.7 0.1 -0.7
Leg fat mass (left) 0.9 3.6 5.6 -1.8 -1.5 -2.4
Arm predicted mass (left) 0.1 0.4 1.1 -1.1 -0.0 0.4