Best TWAS P=9.9e-12 · Best GWAS P=3.21e-08 conditioned to 0.604
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | -5.3 | 5.2 | 1.5e-07 | 0.05 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | STMN3 | 0.07 | 0.02 | lasso | 4 | 0.05 | 2.8e-06 | -4.3 | -6.1 | 8.5e-10 | -0.08 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Artery Coronary | PCMTD2 | 0.23 | 0.11 | enet | 13 | 0.16 | 4.0e-06 | -3.5 | 5.6 | 2.3e-08 | 0.30 | 0.17 | 0.56 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | STMN3 | 0.39 | 0.08 | lasso | 5 | 0.22 | 2.1e-06 | -4.1 | -5.2 | 1.6e-07 | -0.02 | 0.17 | 0.56 | FALSE |
| 5 | GTEx | Brain Cerebellum | STMN3 | 0.33 | 0.12 | lasso | 10 | 0.20 | 1.8e-06 | -4.3 | -5.5 | 4.0e-08 | -0.04 | 0.07 | 0.90 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | CTD-3184A7.4 | 0.09 | 0.00 | enet | 28 | 0.00 | 1.4e-01 | -5.5 | -5.2 | 2.4e-07 | 0.00 | 0.02 | 0.85 | FALSE |
| 7 | GTEx | Whole Blood | STMN3 | 0.10 | 0.00 | lasso | 3 | 0.00 | 1.2e-01 | -3.9 | 6.8 | 9.9e-12 | 0.50 | 0.03 | 0.70 | TRUE |
| 8 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | -5.3 | -5.4 | 6.1e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | -4.7 | -6.3 | 3.0e-10 | -0.05 | 0.01 | 0.79 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | -5.3 | 5.3 | 1.1e-07 | 0.05 | 0.01 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | -5.4 | -5.3 | 1.1e-07 | -0.04 | 0.01 | 0.99 | FALSE |