TWAS hub - CBX7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.094	0.026	2.7e-07	0.066	0.051	0.055	0.055	0.049	1.9e-08	8.0e-07	2.7e-07	2.7e-07	1.1e-06
2	YFS	Blood	0.038	0.011	1.1e-06	0.016	0.025	0.022	0.024	0.019	4.9e-06	1.2e-08	7.5e-08	2.3e-08	3.8e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	12.5	92.3	141.6	-11.9	-6.6
Ever had prostate specific antigen (PSA) test	7.7	8.9	12.3	-3.5	-2.4
Blood Red Count	3.9	37.2	38.2	-6.0	-6.2
Breast Cancer	3.8	9.2	9.6	-3.1	-3.0
Crohns Disease (2012)	3.8	6.1	10.4	-1.4	-3.2
Unable to work because of sickness or disability	3.8	4.9	5.3	2.3	2.1
Fluid intelligence score	3.7	7.8	14.5	3.8	-1.0
Illnesses of father: High blood pressure	3.5	4.3	5.1	-2.2	-1.9
Verbal and Numeric Reasoning (VNR)	3.2	7.6	14.4	3.8	-0.9
Alzheimer’s Disease (including proxy)	3.1	4.5	7.7	2.8	1.1
Hip circumference	3.1	13.3	19.3	4.4	2.7
Arm predicted mass (right)	3.0	15.1	25.4	5.0	2.2
Illnesses of mother	2.9	3.6	3.8	2.0	1.8
Arm fat-free mass (right)	2.9	14.8	25.2	5.0	2.1
Arm fat-free mass (left)	2.9	14.5	26.6	5.2	1.6
Birth weight	2.7	5.8	10.0	3.2	1.3
Arm predicted mass (left)	2.7	13.7	25.2	5.0	1.5
Weight	2.6	13.0	19.3	4.4	2.6
Basal metabolic rate	2.6	14.1	24.4	4.9	2.0
Commuting to job workplace: Cycle	2.6	3.1	5.2	-1.0	-2.3
Pain all over the body in last month	2.5	2.7	5.4	0.2	2.3
Whole body fat-free mass	2.5	14.0	24.9	5.0	1.8
Whole body water mass	2.5	14.1	24.9	5.0	1.8
Intelligence (Savage-Jansen 2018)	2.4	7.5	11.3	3.4	-1.9
Leg predicted mass (left)	2.4	12.8	21.8	4.7	1.9
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	7.7	0.2	-2.8
Medication for cholesterol	2.4	3.6	7.0	2.7	-0.3
Ever taken oral contraceptive pill	2.4	2.6	3.0	-1.7	-1.5
Leg fat-free mass (left)	2.3	12.1	20.6	4.5	1.9
Trunk fat-free mass	2.3	13.5	24.6	5.0	1.5
Trunk predicted mass	2.3	13.2	24.4	4.9	1.4
Leg fat mass (right)	2.3	8.8	9.4	3.1	2.9
Overall health rating	2.3	4.9	9.8	0.3	3.1
Breast cancer (self-reported)	2.2	2.6	4.2	2.1	1.0
Alzheimer’s Disease (in mother)	2.1	2.4	4.8	2.2	0.2
Waist circumference	2.1	7.9	9.1	2.6	3.0
Leg fat-free mass (right)	2.1	11.0	19.4	4.4	1.6
Leg predicted mass (right)	2.1	11.0	19.4	4.4	1.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.9	1.2	1.7
Prospective memory result	2.0	2.5	4.9	-2.2	-0.0
Medication: Paracetamol	1.9	3.1	5.8	-2.4	0.6
Hearing aid user	1.9	2.1	4.1	0.3	-2.0
Leg fat mass (left)	1.9	7.2	7.9	2.8	2.6
Medication for hormone replacement therapy	1.8	2.0	3.8	-1.9	-0.4
Severe depression (siblings)	1.8	2.0	3.6	0.6	1.9
Hair/balding pattern: Pattern 2	1.8	2.4	4.6	0.4	2.1
Wheeze or whistling in the chest in last year	1.8	3.2	4.5	1.4	2.1
Health satisfaction	1.8	2.3	3.8	1.9	1.0
Emphysema/chronic bronchitis	1.8	2.0	2.1	1.5	1.4
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.2	0.5	-2.0
Pulse wave peak to peak time	1.7	2.0	3.7	0.6	1.9
Whole body fat mass	1.7	7.3	8.7	2.9	2.4
Suffer from ‘nerves’	1.7	2.6	3.6	-1.3	-1.9
Age at last live birth	1.7	2.4	3.5	-1.2	-1.9
Lung FEV1/FVC ratio	1.6	8.3	15.2	-1.1	-3.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.7	1.2	1.6
Multivitamins +/- minerals	1.6	2.1	2.5	1.6	1.3
High blood pressure (mother)	1.6	2.2	2.9	-1.7	-1.3
Number of incorrect matches in round	1.6	2.6	5.2	-0.1	2.3
Pulse wave Arterial Stiffness index	1.6	1.9	3.7	-0.2	-1.9
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.6	2.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	5.3	2.3	1.2
Arm fat mass (left)	1.6	6.5	7.9	2.8	2.3
Number of treatments/medications taken	1.5	2.7	4.7	-2.2	0.8
Trunk fat mass	1.5	6.6	8.1	2.8	2.3
Medication for pain relief, constipation, heartburn	1.5	2.6	5.0	2.2	-0.4
Heart disease (mother)	1.5	1.8	2.5	-1.0	-1.6
Heart disease (siblings)	1.5	1.8	3.7	-1.9	0.0
Crohns Disease (2017)	1.4	3.1	6.1	-0.1	-2.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.8	-1.7	-0.9
Arm fat mass (right)	1.4	5.8	7.2	2.7	2.1
Chest pain or discomfort	1.4	2.1	3.7	1.9	-0.7
Guilty feelings	1.4	2.1	4.1	-0.4	-2.0
Eye problems/disorders: Glaucoma	1.4	1.6	2.1	-1.5	-1.0
Medication: Paracetamol	1.4	2.2	3.5	-1.9	1.0
Alzheimer’s Disease (in father)	1.3	1.4	1.5	1.1	1.2
Irritable Bowel Disease (IBD)	1.3	3.2	6.4	0.0	-2.5
Diabetes (mother)	1.3	1.7	2.8	-0.8	1.7
Body mass index (BMI)	1.3	5.4	5.4	2.3	2.3
Happiness	1.3	1.6	2.2	-1.0	-1.5
Standing height	1.3	12.8	24.8	5.0	0.9
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.4	-0.9	-1.5
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.4	1.5	0.9
Osteoarthritis (self-reported)	1.3	1.7	2.6	0.9	1.6
Reaction Time	1.2	2.4	4.7	-2.2	0.1
Bipolar Disorder (2011)	1.2	1.2	2.1	-1.5	-0.4
Ever had hysterectomy (womb removed)	1.2	1.3	2.6	0.3	1.6
Had other major operations	1.2	1.5	3.0	-0.1	1.7
Alcohol intake versus 10 years previously	1.2	1.8	3.3	-1.8	-0.6
Hair/balding pattern: Pattern 4	1.2	2.8	4.5	1.1	2.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	1.6	-1.2	-1.3
Comparative body size at age 10	1.2	3.3	6.1	2.5	0.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	-0.2	1.7
Medication: Ibuprofen	1.2	1.5	2.6	-1.6	-0.6
Illnesses of father: Heart disease	1.2	1.7	2.7	-0.8	-1.7
Mother’s age at death	1.2	1.5	2.0	1.4	1.0
Age at First Birth	1.1	1.5	2.7	-1.7	-0.6
Mean Putamen Volume	1.1	1.2	1.5	-1.2	-1.0
Chronotype (morning person)	1.1	2.6	2.9	-1.5	-1.7
Taking other prescription medications	1.1	1.7	3.3	-0.2	1.8
Medication: Atenolol	1.1	1.4	2.5	-1.6	-0.6
Sitting height	1.1	8.1	15.3	3.9	1.0
Impedance of arm (right)	1.1	5.0	8.6	-2.9	-1.1
Noisy workplace	1.1	1.4	1.6	-1.3	1.1
Leg fat percentage (right)	1.1	4.1	4.9	1.8	2.2
Number of full brothers	1.1	1.3	1.9	1.4	0.9
Comparative height size at age 10	1.1	5.9	11.4	3.4	0.6
Irritability	1.1	1.8	2.4	-1.1	-1.6
Age started oral contraceptive pill	1.1	1.4	2.8	-0.3	-1.7
Rheumatoid Arthritis	1.0	1.4	1.4	-1.2	1.2
Medication: Co-codamol	1.0	1.1	2.2	-0.1	1.5
Had menopause	1.0	1.2	2.4	-0.2	-1.6
Financial difficulties in last 2 years	1.0	1.3	2.7	-0.1	1.6
Time employed in main current job	1.0	1.2	1.2	-1.1	-1.1
Qualifications: College or University degree	1.0	3.2	4.9	1.3	-2.2
Friendships satisfaction	1.0	1.3	1.7	1.3	-0.9
Alcohol drinker status: Never	1.0	1.2	1.6	0.9	1.3
Diastolic blood pressure, automated reading	1.0	3.0	6.0	-0.2	-2.4
Cholesterol lowering medication	1.0	1.5	2.7	-0.7	1.6
Impedance of whole body	1.0	4.9	8.1	-2.9	-1.3
Prostate Cancer	0.9	1.2	1.6	1.2	0.9
BMI	0.9	5.4	5.4	2.3	2.3
Height	0.9	18.2	35.6	6.0	-0.8
Hearing difficulty/problems: Yes	0.9	1.4	2.3	1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.5	-0.8	-1.2
Father’s age at death	0.9	1.2	2.4	0.0	-1.6
Body fat percentage	0.9	3.6	4.1	1.8	2.0
Schizophrenia (2014)	0.8	1.7	2.2	-1.5	1.1
Systolic blood pressure, automated reading	0.8	2.3	3.9	-0.8	-2.0
Trunk fat percentage	0.8	3.3	3.3	1.8	1.8
Serious illness, injury or assault to yourself	0.8	0.9	1.8	0.1	1.4
Qualifications: None of the above	0.8	1.6	2.8	-0.7	1.7
Pulse rate, automated reading	0.8	2.5	3.8	1.9	1.1
Alcohol intake frequency.	0.8	1.9	2.8	-1.0	1.7
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.8	0.4	1.3
Medication: Blood pressure	0.8	1.5	2.8	-1.7	-0.5
Neuroticism (2016)	0.7	1.0	1.8	0.3	1.3
Ulcerative Colitis	0.7	1.1	2.2	-0.0	-1.5
Stomach or abdominal pain in last month	0.7	0.8	1.4	1.2	0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	0.7	1.1
Impedance of leg (left)	0.7	3.3	5.9	-2.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	1.5	0.4	1.2
Impedance of arm (left)	0.7	3.4	5.9	-2.4	-0.9
High blood pressure (siblings)	0.7	1.0	1.6	1.2	0.7
Exposure to tobacco smoke outside home	0.7	0.9	1.7	-1.3	0.3
Number of children fathered	0.7	0.8	1.0	-1.0	-0.9
Mean time to correctly identify matches	0.7	1.4	2.8	-1.7	0.2
Arm fat percentage (left)	0.7	2.7	4.0	1.2	2.0
Long-standing illness, disability or infirmity	0.7	1.1	2.1	1.4	0.5
Back pain experienced in last month	0.7	1.0	1.5	-0.8	-1.2
Medication: Atorvastatin	0.7	0.8	1.4	-0.5	-1.2
Leg fat percentage (left)	0.7	2.6	3.2	1.4	1.8
Ever depressed for a whole week	0.7	0.9	1.7	0.1	-1.3
Bipolar Disorder (2018)	0.6	0.9	1.8	-0.2	1.4
Waist Hip Ratio (WHR)	0.6	2.7	2.8	-1.7	1.6
Respiratory disease	0.6	1.4	2.6	-0.4	1.6
Hand grip strength (left)	0.6	1.6	2.6	0.8	-1.6
Vitamin and mineral supplements	0.6	0.8	1.0	-0.8	-1.0
Hand grip strength (right)	0.6	1.5	2.1	1.0	-1.4
Supplements: Glucosamine	0.6	0.7	1.3	1.1	0.4
Alcohol usually taken with meals	0.6	1.0	1.5	1.2	0.7
Medication: Lansoprazole	0.6	0.7	1.3	-1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	-1.2	-0.1
Mood swings	0.6	1.1	1.7	-1.3	-0.7
Loneliness, isolation	0.6	0.9	1.5	-1.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	-0.1	1.2
Eye problems/disorders: Cataract	0.6	0.7	1.5	0.2	1.2
Medication: Aspirin	0.6	0.8	1.3	-1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.3	1.1	1.1
Commuting to job workplace: Public transport	0.6	0.8	1.5	0.3	-1.2
Average weekly beer plus cider intake	0.6	0.9	1.9	-1.4	0.0
Pack years of smoking	0.6	0.9	1.0	-0.9	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.1	1.5	-0.8	1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	-0.3	1.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	1.2	-0.2
HDL Cholesterol	0.5	0.9	1.2	1.1	0.8
Age when periods started (menarche)	0.5	1.2	2.4	0.1	1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-1.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	0.9	0.6
Arm fat percentage (right)	0.5	1.8	2.7	1.0	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-0.1	-1.3
Birth weight of first child	0.5	0.9	1.8	1.3	-0.1
Worry too long after embarrassment	0.5	0.9	1.8	1.4	0.1
Neck or shoulder pain in last month	0.5	0.6	1.1	1.1	-0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.2	1.1
Family relationship satisfaction	0.5	0.6	1.1	1.1	0.3
Leg pain on walking	0.5	0.6	1.2	-0.3	-1.1
Average weekly red wine intake	0.5	0.8	1.4	0.4	1.2
Osteoporosis (self-reported)	0.5	0.6	0.9	0.5	0.9
Wears glasses or contact lenses	0.5	0.5	1.0	0.3	-1.0
High cholesterol (Self-reported)	0.5	0.8	1.6	-1.3	-0.1
Medication: Lisinopril	0.5	0.6	1.2	0.1	1.1
Ever smoked	0.5	0.9	1.3	0.7	1.2
Ulcerative Colitis (UC)	0.4	0.8	1.4	0.4	-1.2
Systolic Blood Pressure	0.4	1.9	3.1	-0.8	-1.8
Allergy or Eczema	0.4	1.1	2.1	0.1	1.4
Average weekly spirits intake	0.4	0.5	0.7	-0.8	-0.6
Sensitivity / hurt feelings	0.4	0.7	1.2	-0.5	-1.1
Impedance of leg (right)	0.4	1.9	3.7	-1.9	-0.2
Average weekly fortified wine intake	0.4	0.5	0.6	-0.6	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.2	-1.1
Neuroticism score	0.4	0.9	1.0	-1.0	-0.9
Falls in the last year	0.4	0.6	0.9	1.0	0.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.1	-1.1
Asthma	0.4	0.9	1.6	-0.4	1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.2	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.6	-0.7	-0.8
Age at first live birth	0.4	0.6	1.1	-0.4	-1.1
Supplements: Vitamin C	0.4	0.5	0.9	-1.0	-0.3
Asthma (self-reported)	0.4	0.8	1.3	-0.5	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.5	-0.9
Schizophrenia (2018)	0.3	0.6	0.9	-0.9	0.6
Ovarian Cancer	0.3	0.4	0.4	0.7	-0.5
HbA1C	0.3	0.3	0.5	-0.7	0.4
Blood Platelet Count	0.3	3.5	6.8	-2.6	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.4	0.8
Diabetes (father)	0.3	0.4	0.7	-0.0	0.9
Pack years adult smoking proportion	0.3	0.5	0.5	-0.7	-0.7
Relative age voice broke	0.3	0.5	1.0	0.3	-1.0
Nervous feelings	0.3	0.5	1.1	-0.2	1.0
Mouth/teeth dental problems	0.3	0.5	1.0	-0.0	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	-0.5	0.9
Depression (self-reported)	0.3	0.3	0.4	-0.6	0.5
Length of working week for main job	0.3	0.4	0.7	0.8	0.0
Pulse wave reflection index	0.3	0.4	0.7	0.9	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	2.0	1.4	0.2
Medication: Aspirin	0.3	0.4	0.5	-0.7	0.5
Hypertension (Self-reported)	0.3	0.7	1.2	-1.1	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.7	-0.4
Ever had bowel cancer screening	0.3	0.3	0.6	-0.8	0.2
Commuting to job workplace: Walk	0.3	0.3	0.4	0.7	-0.5
Mineral and other dietary supplements	0.3	0.4	0.5	-0.7	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	0.6	0.7
Number of self-reported non-cancer illnesses	0.3	0.6	0.9	-0.9	0.5
Miserableness	0.3	0.5	0.6	-0.8	-0.6
Myopia	0.3	0.5	0.9	0.4	-0.9
Coronary Artery Disease (CAD)	0.2	0.3	0.5	-0.3	0.7
Blood Eosinophil Count	0.2	1.3	2.4	-1.6	-0.4
Supplements: Zinc	0.2	0.2	0.4	0.7	-0.0
Medication: Metformin	0.2	0.3	0.4	0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.4	-0.7	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	-0.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.3	0.6
High blood pressure	0.2	0.5	0.9	-0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.4	0.7
Medication: Ramipril	0.2	0.2	0.4	-0.7	-0.1
Medication: Simvastatin	0.2	0.2	0.4	-0.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.6	0.7	-0.8
Pulse rate	0.2	0.3	0.4	-0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	0.9	-0.5
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.3	-0.9
Loud music exposure frequency	0.2	0.2	0.5	0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	0.7	0.5
Gout (self-reported)	0.2	0.3	0.6	-0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.4	0.3	-0.7
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.7	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.1	-0.6
Migraine (self-reported)	0.2	0.2	0.4	0.1	0.6
Medication: Omeprazole	0.2	0.3	0.5	0.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.4	0.5
Number of full sisters	0.2	0.2	0.2	0.5	0.5
Knee pain experienced in last month	0.2	0.3	0.4	0.5	0.6
Medication: Gliclazide	0.2	0.2	0.3	0.6	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.3	0.6	-0.5
Financial situation satisfaction	0.2	0.2	0.3	-0.5	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.2	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.2	-0.7
Medication: Bendroflumethiazide	0.2	0.4	0.7	-0.2	0.8
Risk taking	0.2	0.3	0.4	0.6	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.1	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	1.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.2	0.6
Alcohol drinker status: Previous	0.2	0.2	0.4	0.3	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.6	0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.7	-0.0
LDL Cholesterol	0.1	0.2	0.4	0.6	-0.1
Lupus	0.1	0.1	0.1	0.4	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.1	0.4
Heel T-Score	0.1	0.5	0.7	-0.5	0.8
Smoking Status	0.1	0.2	0.4	-0.6	-0.1
Cardiovascular Disease	0.1	0.3	0.5	-0.7	-0.2
Hypothyroidism (self reported)	0.1	0.3	0.4	-0.4	0.6
Lung FVC	0.1	0.6	1.2	-1.1	0.1
Neuroticism	0.1	0.3	0.5	-0.4	-0.7
Hair Pigment	0.1	1.5	2.9	-1.7	0.3
Tanning	0.1	0.6	0.8	-0.7	0.9
Relative age of first facial hair	0.1	0.2	0.4	0.2	-0.6
Angina	0.1	0.1	0.3	-0.5	0.0
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	-0.5
Current tobacco smoking	0.1	0.2	0.4	-0.6	-0.2
Maternal smoking around birth	0.1	0.2	0.3	0.0	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.2	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.4	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.7	0.1
Past tobacco smoking	0.1	0.2	0.2	-0.4	-0.5
Forced vital capacity (FVC)	0.1	0.5	1.1	1.0	0.0
Allergy	0.1	0.3	0.4	0.3	-0.6
Diabetes (self-reported)	0.1	0.2	0.3	0.6	-0.1
Illnesses of siblings	0.1	0.1	0.2	-0.0	-0.4
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	0.0
Number of live births	0.1	0.2	0.3	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.4	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.1	-0.4
Medication: Cholesterol lowering	0.1	0.2	0.3	0.2	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	-0.0
Breastfed as a baby	0.1	0.1	0.2	-0.4	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.0	-0.4
Headache pain in last month	0.1	0.2	0.3	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	0.5
Medication: Blood pressure	0.1	0.2	0.4	0.2	0.6
Angina (self-reported)	0.1	0.1	0.2	-0.4	0.0
Smoking status: Previous	0.1	0.2	0.2	0.4	-0.4
Diabetes diagnosed by doctor	0.1	0.1	0.1	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3
Smoking status: Current	0.1	0.2	0.3	-0.5	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.2	-0.6
Depression (Nagel 2018)	0.0	0.0	0.0	0.1	0.2
Worry (Nagel 2018)	0.0	0.0	0.1	-0.2	-0.2
Major Depression (MDD)	0.0	0.0	0.1	-0.0	0.2
Fasting Glucose	0.0	0.0	0.0	0.0	0.2
Triglycerides	0.0	0.0	0.0	-0.2	-0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.3	-0.2
Fed-up feelings	0.0	0.1	0.1	-0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.0	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	0.1
Heart attack	0.0	0.0	0.0	0.1	-0.2
Lung cancer (father)	0.0	0.0	0.1	-0.1	0.3
Tense / ‘highly strung’	0.0	0.0	0.1	0.0	-0.3
Glaucoma (self-reported)	0.0	0.0	0.1	0.2	-0.2
Medication: Amlodipine	0.0	0.0	0.0	-0.1	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.0	-0.2
Medication: Allopurinol	0.0	0.0	0.1	-0.3	-0.0
Had major operations	0.0	0.1	0.1	-0.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.3	-0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.4	-0.0
Number of operations (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Pain experienced in last month	0.0	0.0	0.1	0.3	0.2
Supplements: Calcium	0.0	0.1	0.1	-0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

CBX7

Models

Trait associations