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chr22:28,792,887-32,995,751

Best TWAS P=3.6e-15 · Best GWAS P=2.86e-15 conditioned to 9.05e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Esophagus Muscularis	LIMK2	0.08	0.03	lasso	4	0.01	4.3e-02	-7.50	7.9	3.6e-15	-0.90	0.02	0.94	TRUE
24	GTEx	Pancreas	EMID1	0.19	0.18	lasso	8	0.17	1.2e-07	-6.96	-6.5	5.7e-11	-0.11	0.00	1.00	TRUE
13	GTEx	Breast Mammary Tissue (Female)	CTA-85E5.10	0.13	-0.01	lasso	4	-0.01	5.7e-01	-5.45	6.4	1.6e-10	0.09	0.05	0.12	TRUE
7	GTEx	Brain Caudate basal ganglia	CTA-85E5.10	0.35	0.06	lasso	9	0.03	6.1e-02	3.22	6.2	5.5e-10	0.02	0.07	0.50	TRUE
31	GTEx	Whole Blood	NIPSNAP1	0.05	0.00	enet	19	0.01	8.8e-02	4.90	-5.7	1.0e-08	-0.10	0.10	0.03	TRUE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF4ENIF1	0.08	0.06	enet	5	0.06	3.4e-04	-7.90	-7.6	3.4e-14	0.97	0.00	0.99	FALSE
5	GTEx	Artery Aorta	SFI1	0.10	0.01	enet	23	0.02	1.9e-02	-4.37	7.3	2.1e-13	-0.74	0.10	0.77	FALSE
30	GTEx	Thyroid	RNF185	0.05	0.03	lasso	4	0.02	5.1e-03	-7.63	-7.3	2.9e-13	0.97	0.02	0.96	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	SFI1	0.15	0.07	lasso	3	0.06	3.7e-03	-7.50	7.2	6.3e-13	-0.82	0.04	0.83	FALSE
23	GTEx	Nerve Tibial	SFI1	0.23	0.06	enet	16	0.14	1.9e-10	-4.76	6.8	8.7e-12	-0.74	0.12	0.87	FALSE
19	GTEx	Esophagus Muscularis	SFI1	0.22	0.13	enet	20	0.15	3.7e-09	-5.41	6.5	1.0e-10	-0.86	0.05	0.95	FALSE
32	GTEx	Whole Blood	SFI1	0.05	0.05	lasso	2	0.04	3.0e-04	-6.40	6.5	1.0e-10	-0.84	0.04	0.94	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASCC2	0.04	0.02	enet	6	0.03	6.0e-04	-5.55	6.4	1.9e-10	0.08	0.01	0.93	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	ZMAT5	0.10	0.00	lasso	4	0.00	5.0e-01	-5.64	-6.3	2.2e-10	-0.10	0.08	0.39	FALSE
53	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	EIF4ENIF1	0.21	0.03	enet	5	0.08	2.9e-03	-5.57	-6.2	4.9e-10	0.32	0.06	0.08	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	RNF185	0.18	0.10	enet	6	0.12	9.7e-04	-6.58	-6.2	5.4e-10	0.71	0.03	0.32	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFI1	0.05	0.06	enet	3	0.04	1.9e-05	5.99	6.1	1.1e-09	-0.87	0.01	0.99	FALSE
38	YFS	Blood	SFI1	0.19	0.14	enet	36	0.24	9.8e-76	-2.42	6.0	1.4e-09	-0.65	1.00	0.00	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ZMAT5	0.06	0.03	enet	15	0.02	4.4e-03	-4.90	-6.0	2.3e-09	-0.08	0.12	0.82	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	RNF185	0.06	0.09	lasso	4	0.07	1.5e-07	-6.08	-6.0	2.5e-09	0.69	0.34	0.66	FALSE
10	GTEx	Brain Putamen basal ganglia	SFI1	0.23	0.06	enet	18	0.06	1.4e-02	6.05	5.9	3.1e-09	-0.68	0.05	0.62	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF185	0.09	0.05	enet	21	0.09	1.3e-10	-7.64	5.9	3.3e-09	-0.81	0.02	0.98	FALSE
8	GTEx	Brain Cerebellum	CTA-85E5.10	0.13	0.09	lasso	4	0.02	1.1e-01	-6.21	5.9	3.5e-09	0.11	0.08	0.38	FALSE
6	GTEx	Artery Tibial	SFI1	0.12	0.04	enet	21	0.09	8.5e-08	-4.31	5.9	3.8e-09	-0.70	0.07	0.93	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	SFI1	0.05	0.03	lasso	4	0.02	2.4e-03	5.89	5.8	5.5e-09	-0.83	0.01	0.96	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	UQCR10	0.12	0.03	lasso	4	0.06	6.6e-03	-5.65	5.8	6.3e-09	0.10	0.12	0.11	FALSE
20	GTEx	Heart Left Ventricle	SFI1	0.12	0.10	enet	20	0.07	2.3e-04	6.06	5.8	7.9e-09	-0.85	0.20	0.75	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIMK2	0.06	0.06	blup	47	0.06	9.3e-08	-4.51	5.8	8.6e-09	-0.71	0.77	0.23	FALSE
12	GTEx	Breast Mammary Tissue	CTA-85E5.10	0.14	-0.01	enet	13	0.00	6.1e-01	3.87	5.7	1.1e-08	-0.02	0.13	0.10	FALSE
42	The Cancer Genome Atlas	Glioblastoma Multiforme	SFI1	0.23	0.03	blup	93	0.04	2.7e-02	-2.64	5.6	1.7e-08	-0.66	0.03	0.24	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	HORMAD2	0.06	0.04	enet	10	0.07	5.7e-07	6.51	-5.6	1.9e-08	-0.11	0.01	0.99	FALSE
29	GTEx	Testis	ZMAT5	0.09	0.08	lasso	2	0.05	2.3e-03	-5.55	5.6	2.0e-08	0.13	0.14	0.41	FALSE
33	NTR	Blood	DEPDC5	0.02	0.02	lasso	5	0.01	2.4e-05	-5.31	5.6	2.3e-08	-0.72	0.14	0.84	FALSE
36	YFS	Blood	LIMK2	0.04	0.04	enet	9	0.06	3.6e-18	-6.40	-5.6	2.4e-08	0.78	0.98	0.02	FALSE
35	NTR	Blood	PISD	0.05	0.08	lasso	5	0.09	3.3e-27	-5.31	5.6	2.6e-08	-0.75	1.00	0.00	FALSE
34	NTR	Blood	KREMEN1	0.05	0.04	lasso	5	0.04	1.4e-12	4.48	-5.6	2.7e-08	-0.03	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	SFI1	0.15	0.06	lasso	7	0.10	2.3e-08	-4.31	5.5	3.2e-08	-0.61	0.91	0.08	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	PISD	0.05	0.00	blup	54	0.05	1.0e-03	-1.89	-5.5	3.6e-08	0.64	0.02	0.74	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SFI1	0.05	0.01	blup	386	0.04	1.6e-05	5.99	5.5	4.0e-08	-0.83	0.04	0.96	FALSE
28	GTEx	Skin Sun Exposed Lower leg	UQCR10	0.07	0.10	lasso	8	0.09	5.5e-08	-5.45	-5.5	4.4e-08	-0.10	0.75	0.25	FALSE
16	GTEx	Colon Transverse	PIK3IP1	0.13	0.08	lasso	3	0.04	6.0e-03	-5.45	5.5	5.1e-08	-0.28	0.35	0.03	FALSE
11	GTEx	Breast Mammary Tissue	AC005003.1	0.05	0.01	lasso	5	0.02	4.5e-02	-5.45	-5.4	5.5e-08	0.27	0.18	0.05	FALSE
15	GTEx	Cells Transformed fibroblasts	NIPSNAP1	0.12	0.17	enet	11	0.13	3.1e-10	4.90	-5.4	5.8e-08	-0.11	1.00	0.00	FALSE
21	GTEx	Muscle Skeletal	SFI1	0.13	0.09	enet	22	0.10	1.7e-10	6.06	5.3	8.6e-08	-0.86	0.02	0.98	FALSE
37	YFS	Blood	RNF185	0.04	0.03	lasso	4	0.03	2.8e-09	-5.44	-5.3	1.3e-07	0.83	0.94	0.06	FALSE
22	GTEx	Nerve Tibial	PIK3IP1	0.09	0.05	enet	11	0.09	3.5e-07	-3.95	5.3	1.4e-07	-0.46	0.87	0.08	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	SFI1	0.12	0.00	enet	12	0.05	1.4e-03	-5.45	5.2	1.5e-07	-0.77	0.03	0.91	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SELM	0.06	0.01	blup	54	0.02	5.2e-03	2.67	-5.2	1.6e-07	0.73	0.05	0.82	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	NIPSNAP1	0.20	0.00	enet	10	-0.01	6.7e-01	4.99	-5.2	1.7e-07	-0.12	0.07	0.14	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NF2	0.02	0.01	blup	72	0.00	8.4e-02	4.95	5.2	1.7e-07	0.10	0.04	0.61	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFI1	0.11	0.02	lasso	3	0.04	4.3e-03	-4.57	5.2	1.7e-07	-0.36	0.06	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NIPSNAP1	0.16	0.15	enet	19	0.12	8.7e-15	4.98	-5.2	2.1e-07	-0.10	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	PISD	0.06	0.01	lasso	4	0.04	7.7e-05	-0.76	-5.2	2.1e-07	0.57	0.02	0.96	FALSE