Hub : Genes

CBX6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1140	0.0440	4.8e-03	0.060	NA	0.086	NA	0.088	2.7e-05	NA	5.1e-07	NA	4.2e-07
2	GTEx	Nerve Tibial	0.1366	0.0520	2.1e-03	0.012	NA	0.057	NA	0.029	4.7e-02	NA	7.0e-05	NA	3.8e-03
3	GTEx	Whole Blood	0.0800	0.0310	4.9e-03	0.029	NA	0.027	NA	0.014	1.0e-03	NA	1.4e-03	NA	1.8e-02
4	YFS	Blood	0.1272	0.0261	2.8e-16	0.032	0.061	0.056	0.058	0.049	1.0e-10	3.6e-19	9.7e-18	2.1e-18	7.8e-16
5	TCGA	Bladder Urothelial Carcinoma	0.0830	0.0450	8.5e-03	0.005	0.005	0.006	NA	0.011	1.2e-01	1.1e-01	9.2e-02	NA	4.0e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0596	0.0279	4.1e-06	0.024	0.044	0.042	NA	0.043	8.8e-04	8.7e-06	1.4e-05	NA	1.3e-05
7	TCGA	Thyroid Carcinoma	0.1300	0.0820	3.1e-03	0.016	0.015	0.030	NA	0.024	1.0e-02	1.3e-02	5.6e-04	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	1.0	-0.0	-1.0	-0.9	-0.7	-0.1	-0.3	0.0
Bipolar Disorder or Schizophrenia	0.6	1.5	3.7	1.2	-1.0	-0.7	-1.9	-0.2	1.9	0.5
Depressed Affect (Nagel 2018)	0.8	1.8	5.0	1.3	1.1	-1.6	-0.1	2.2	0.6	1.2
Depression (Nagel 2018)	0.7	1.1	5.6	0.4	0.7	-0.3	0.4	2.4	1.1	0.3
Intelligence (Savage-Jansen 2018)	1.9	5.8	14.8	-3.0	-0.7	-0.6	-1.9	-1.9	-3.9	-3.0
Neuroticism (Nagel 2018)	0.6	1.3	3.9	1.0	0.3	-2.0	-0.2	1.9	0.0	0.8
Schizophrenia (2018)	0.9	2.0	7.5	1.5	-0.6	-0.1	-1.8	-0.2	2.7	0.6
Schizophrenia vs Biploar Disorder	2.3	3.0	10.7	1.6	0.6	0.8	1.2	-1.0	3.3	2.0
Worry (Nagel 2018)	0.3	0.6	2.0	-0.7	-0.3	-0.4	-0.3	0.7	-1.4	-1.0
Alzheimer’s Disease (in mother)	1.2	1.4	3.3	1.6	-0.6	-0.8	0.6	0.8	1.8	1.5
Alzheimer’s Disease (in father)	0.9	0.9	4.5	-0.9	-0.5	-2.1	-0.5	0.3	-0.3	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	4.2	1.1	-0.8	-2.0	0.7	0.9	1.8	0.9
Crohns Disease (2017)	0.4	0.9	2.2	-0.8	0.5	-0.6	-0.8	1.5	-1.2	-0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.5	-0.7	0.5	-1.2	-1.1	0.4	-1.1	-0.7
Ulcerative Colitis (UC)	0.4	0.8	2.5	-0.5	0.3	-1.6	-0.9	-0.8	-0.8	-0.4
Major Depression (MDD)	0.2	0.2	1.0	0.3	0.1	-0.2	-1.0	-0.1	0.3	-0.4
Reaction Time	1.0	1.9	4.4	2.0	1.5	0.9	0.2	-0.2	2.1	1.3
Verbal and Numeric Reasoning (VNR)	3.0	7.1	13.6	-3.0	-1.1	-2.2	-3.0	-1.6	-3.7	-3.2
Breast Cancer	3.2	7.6	12.7	3.3	3.6	3.3	2.5	1.2	1.4	3.1
Ovarian Cancer	0.7	0.9	2.3	1.5	0.8	-0.4	-0.0	1.2	0.4	1.3
Prostate Cancer	1.9	2.6	9.5	-0.6	-3.1	-1.7	-1.9	-1.3	0.2	-0.5
Age at First Birth	0.6	0.9	2.6	-0.8	1.1	1.6	0.7	-0.9	0.0	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	-0.5	0.0
Body Mass Index (BMI) (2010)	0.8	1.0	2.8	1.1	-0.8	-1.7	-0.9	1.0	0.7	0.7
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.7	0.3	0.3	1.4	0.0	-0.4	0.0
Crohns Disease (2012)	1.0	1.7	3.4	-1.8	0.8	0.6	-0.3	1.5	-1.7	-1.5
Mean Putamen Volume	0.8	0.9	2.2	1.5	0.8	0.9	1.0	0.5	0.9	0.9
Fasting Glucose	1.6	1.9	3.4	1.4	1.2	-1.2	-0.9	1.8	1.5	1.5
HbA1C	1.0	1.1	2.0	-1.3	0.7	1.2	-0.1	-0.5	-1.4	-1.3
HDL Cholesterol	1.0	1.6	4.6	1.5	-0.3	1.4	2.1	0.3	0.9	1.4
LDL Cholesterol	0.6	1.0	2.7	-1.4	-0.5	0.5	0.7	-0.8	-1.0	-1.6
Lupus	1.7	2.5	6.5	-1.2	0.1	-2.2	-0.5	-2.6	-1.4	-1.6
Neuroticism (2016)	1.0	1.4	4.9	1.3	0.6	-0.2	1.6	2.2	0.6	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.8	-0.2	1.4	-1.2	-0.5	0.2	-0.5	0.0
Rheumatoid Arthritis	0.9	1.2	4.0	-1.0	1.4	-0.1	0.0	-0.7	-2.0	-1.0
Schizophrenia (2014)	1.1	2.4	9.1	1.7	-1.0	-0.5	-1.5	-0.4	3.0	0.9
Triglycerides	2.2	3.7	10.9	-1.8	-0.9	-1.8	-3.3	-1.0	-1.5	-2.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	4.0	0.5	0.1	1.0	0.6	0.8	2.0	0.4
Ulcerative Colitis	0.5	0.7	1.1	-1.0	0.4	-0.6	-0.8	-0.5	-1.1	-1.1
Blood Eosinophil Count	0.4	3.4	6.7	2.3	2.1	0.6	0.9	1.1	2.6	2.3
Blood Platelet Count	0.5	5.6	30.7	0.6	5.5	-1.1	2.5	-1.0	0.1	-0.2
Blood Red Count	1.1	10.8	27.1	3.0	3.1	5.2	2.7	1.2	3.4	3.1
Blood White Count	1.7	12.7	33.5	3.0	5.8	3.9	3.8	0.3	2.6	3.1
Heel T-Score	1.7	13.5	32.0	4.8	-1.1	-0.9	1.5	2.2	5.5	5.7
BMI	0.8	4.4	8.3	2.5	0.3	-2.4	1.0	2.0	2.9	2.2
Height	2.5	47.8	88.2	-9.4	-5.5	-0.2	-6.5	-5.2	-8.5	-8.7
Waist Hip Ratio (WHR)	0.6	2.9	7.8	2.0	-1.1	1.1	1.5	0.1	1.9	2.8
Systolic Blood Pressure	0.2	1.2	3.4	-0.8	-0.8	1.8	-0.4	-0.7	-1.1	-1.3
Smoking Status	1.9	4.6	10.5	2.2	-0.3	-2.1	-0.9	3.2	2.0	2.7
Allergy or Eczema	0.5	1.4	4.7	-1.4	0.1	0.5	1.0	-2.2	-0.9	-1.2
Cardiovascular Disease	0.6	1.9	4.5	-1.8	-1.4	-0.2	-0.5	-0.5	-1.6	-2.1
Hypothyroidism (self reported)	0.2	0.4	1.8	0.1	-0.4	-1.3	-0.4	0.8	-0.5	-0.1
Respiratory disease	1.4	3.1	7.9	1.9	-1.0	-1.6	-0.7	-0.2	2.5	2.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	1.1	-0.4	-1.5	-1.1	-0.4	0.2	1.6
Lung FEV1/FVC ratio	0.2	1.2	5.2	0.7	1.4	0.3	-2.3	1.0	0.0	0.1
Lung FVC	1.0	4.9	9.4	-3.1	1.0	1.7	1.9	-1.7	-2.4	-2.9
Neuroticism	0.5	1.3	1.9	1.0	1.4	-1.3	0.9	1.3	0.6	1.2
Chronotype (morning person)	2.6	6.0	15.4	-2.7	1.0	-0.9	-3.9	-1.3	-2.9	-2.8
Hair Pigment	0.1	2.4	4.3	-1.3	1.3	1.8	2.1	0.5	-2.0	-1.4
Tanning	0.0	0.3	1.1	-0.4	1.1	0.2	0.7	0.4	0.0	-0.4
Hand grip strength (left)	0.2	0.4	1.5	-0.1	1.2	0.9	0.1	-0.1	0.9	0.2
Number of treatments/medications taken	0.2	0.3	0.7	0.8	0.5	0.5	0.2	0.6	-0.1	0.9
Average weekly spirits intake	0.2	0.2	1.3	-0.1	0.0	1.2	0.3	-0.0	0.3	0.4
Sensitivity / hurt feelings	0.8	1.4	3.9	0.9	-0.7	-2.0	-1.4	0.9	-0.0	1.5
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.7	1.5	1.0	0.4	1.7	2.4	2.1	1.5
Hearing difficulty/problems: Yes	1.8	2.7	6.2	2.4	0.4	1.2	0.7	1.0	2.0	2.5
Relative age of first facial hair	1.1	2.3	6.7	-1.5	0.0	-0.6	-1.4	1.4	-2.6	-1.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.9	-1.3	0.2	-1.5	-1.0	-1.0	-1.5	-1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.5	-0.1	0.9	-1.1	-1.9	-0.3	-0.4	-0.7
Ever had hysterectomy (womb removed)	2.7	3.1	6.3	-2.3	-1.0	-0.8	-1.4	-2.2	-1.1	-2.5
Systolic blood pressure, automated reading	0.2	0.6	2.7	0.5	0.2	1.6	-0.2	-1.2	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	1.0	-0.0	-0.6	-0.0	-0.1	-0.2	1.2
Angina	0.6	0.7	3.3	-0.6	0.3	-1.8	0.7	-0.7	-0.4	-0.5
Medication for hormone replacement therapy	1.0	1.1	3.3	-0.4	0.4	-1.2	-1.5	-1.8	-0.5	-0.2
Vitamin and mineral supplements	0.7	0.9	2.7	-1.0	-0.0	0.9	-0.4	-1.6	-1.2	-0.2
Supplements: Zinc	0.5	0.5	1.2	-0.7	-0.6	-0.5	-0.6	-0.3	-0.8	-1.1
Medication: Co-codamol	1.0	1.2	2.2	1.0	-0.2	-1.4	-1.5	1.4	1.0	0.6
Medication: Metformin	0.3	0.4	1.0	0.9	-0.6	-0.8	-0.0	-0.1	-0.4	1.0
Diabetes (father)	0.2	0.2	0.7	0.2	0.5	-0.8	0.1	0.0	-0.8	-0.1
Diabetes (mother)	1.0	1.3	3.2	1.0	1.8	0.9	1.6	-0.1	1.2	0.5
Severe depression (siblings)	0.2	0.3	1.2	0.4	-0.4	-0.1	0.4	1.1	-0.3	0.3
Pack years adult smoking proportion	0.2	0.4	1.1	-0.3	0.5	-0.6	-0.5	-1.1	-0.7	0.3
Impedance of leg (right)	1.2	6.0	12.3	-3.1	-0.5	1.0	-1.0	-3.5	-3.3	-2.7
Leg fat-free mass (left)	0.2	1.2	5.8	-0.4	-0.9	-2.4	-1.0	0.1	0.6	-0.5
Trunk fat percentage	0.3	1.2	6.8	-0.3	0.4	-2.6	-0.4	-0.9	-0.4	0.0
Hand grip strength (right)	0.1	0.3	1.1	-1.0	-0.4	0.2	-0.5	-0.3	-0.3	-0.8
Townsend deprivation index at recruitment	0.4	0.5	2.7	-0.3	0.6	0.2	-0.2	-1.6	0.5	-0.1
Current tobacco smoking	1.1	1.8	3.9	1.4	-0.5	-0.7	-0.9	1.7	2.0	1.6
Average weekly fortified wine intake	1.5	1.8	4.0	-1.3	-0.3	1.3	0.1	-2.0	-0.9	-2.0
Maternal smoking around birth	1.3	1.9	3.8	1.4	-0.5	0.8	0.6	1.6	1.9	1.9
Fed-up feelings	3.0	5.5	11.4	3.2	0.9	-0.5	1.2	2.2	3.4	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	5.3	1.0	1.6	0.1	1.0	1.5	2.3	0.8
Relative age voice broke	1.4	2.2	9.0	-1.4	-0.1	1.1	0.7	0.8	-3.0	-1.4
Taking other prescription medications	0.1	0.2	0.7	-0.0	0.8	0.0	0.6	0.2	-0.3	0.3
Age when periods started (menarche)	3.1	7.6	15.9	-3.3	-2.4	-0.1	-2.8	-1.0	-4.0	-3.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.2	-0.7	0.5	-1.8	-1.7	-1.1	0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	0.9	-0.4	0.8	0.8	-0.5	1.6	1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	0.6	1.2	-0.2	-0.6	1.0	0.7	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.6	0.0	0.3	-0.8	-0.4	-0.1	0.0	-0.2
Serious illness, injury or assault to yourself	1.1	1.3	7.8	-0.2	-0.3	0.8	2.8	-0.4	0.1	-0.7
High blood pressure	0.2	0.7	1.2	-0.6	-0.4	0.6	1.0	-0.9	-1.1	-0.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.1	-0.6	0.2	0.9	0.4	-2.0	-0.4	-0.6
Multivitamins +/- minerals	0.2	0.3	0.9	-0.2	-0.5	-0.9	0.6	0.0	-0.2	-0.8
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.7	0.2	-0.7	0.6	-0.4	-0.4	-0.8
Supplements: Glucosamine	0.5	0.7	2.2	-0.3	-0.0	1.5	0.5	-0.1	-1.1	-0.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.1	0.8	2.3	0.3	-0.6	-1.6	1.3	0.6
Medication: Atenolol	1.0	1.3	3.0	-1.7	-0.9	0.0	-0.5	-0.2	-1.7	-1.4
Medication: Levothyroxine sodium	0.3	0.5	1.5	0.6	-0.1	-1.0	-0.6	1.2	-0.6	0.3
Sitting height	0.6	4.3	9.0	-3.0	-2.2	-0.7	-0.7	-1.7	-2.4	-2.6
Chronic bronchitis/emphysema (father)	2.1	2.5	6.1	2.0	0.3	0.8	2.5	0.3	2.0	1.5
High blood pressure (mother)	0.5	0.7	1.5	-0.6	0.1	1.2	-0.6	-1.0	-1.2	-0.7
Body mass index (BMI)	1.1	4.8	8.5	2.7	1.0	-2.6	0.7	1.4	2.9	2.7
Impedance of leg (left)	1.2	5.9	11.5	-3.2	-0.6	1.1	-0.8	-3.1	-3.4	-2.7
Leg predicted mass (left)	0.3	1.4	6.1	-0.5	-1.1	-2.5	-1.2	0.0	0.6	-0.6
Trunk fat mass	0.3	1.4	7.3	-0.7	0.1	-2.7	-0.6	-1.0	-0.7	-0.4
Waist circumference	0.6	2.4	5.5	1.8	0.2	-2.3	0.2	-0.2	1.7	2.2
Number of incorrect matches in round	0.2	0.4	1.1	-0.7	-0.3	-0.6	-0.4	0.0	-1.0	-0.7
Past tobacco smoking	2.1	3.9	6.8	-2.3	-1.0	1.1	-0.8	-2.5	-2.5	-2.6
Alcohol usually taken with meals	0.3	0.5	2.0	-0.3	0.5	1.4	-0.4	0.1	-0.8	-0.1
Nervous feelings	0.2	0.4	1.0	-0.6	-0.6	-0.8	0.2	0.1	-1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.4	-0.2	-0.5	0.3	0.7	0.8	-0.1
Hearing difficulty/problems with background noise	6.0	9.6	19.2	4.4	2.0	2.2	1.8	1.4	3.9	4.3
Hair/balding pattern: Pattern 2	1.1	1.4	4.4	0.3	2.1	-0.3	1.9	0.6	1.0	0.2
Had menopause	0.6	0.7	2.1	0.7	1.5	1.3	0.6	-0.5	-0.0	0.2
Had other major operations	1.0	1.2	3.1	0.9	0.3	1.4	1.7	-0.0	1.4	0.5
Forced vital capacity (FVC)	1.1	4.2	10.7	-3.3	-0.1	0.7	-0.6	-1.7	-2.2	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.8	0.9	-0.6	0.1	0.3	-0.5	2.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.7	1.5	0.5	1.4	1.4	-0.5	-0.7
Qualifications: None of the above	2.9	6.2	13.0	3.6	0.9	-1.4	0.9	1.8	3.3	3.6
Financial difficulties in last 2 years	0.3	0.4	2.1	0.4	0.1	0.4	1.5	0.2	0.3	0.1
Mouth/teeth dental problems	0.7	1.0	1.9	-0.6	0.1	1.4	-0.5	-1.4	-1.4	-0.8
Heart attack	0.2	0.2	0.7	-0.8	-0.8	-0.1	0.2	-0.1	-0.2	0.2
Allergy	0.3	0.7	3.8	-0.4	-0.5	0.1	-0.2	2.0	-0.3	-0.5
Pain all over the body in last month	1.4	1.5	6.9	0.3	-1.7	-2.6	-0.1	0.6	0.1	0.3
Diabetes (self-reported)	0.5	0.7	1.7	1.2	-0.5	-0.8	-0.7	-0.5	-0.5	1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	0.9	0.6	-0.0	0.7	-1.4	0.8	1.3
Medication: Ramipril	0.3	0.4	0.9	-0.7	-0.9	0.9	0.5	-0.6	-0.2	-0.2
Medication: Simvastatin	0.7	1.0	2.3	-1.3	-1.2	-0.1	-0.6	-0.3	-1.5	-1.0
Fluid intelligence score	2.3	4.7	9.8	-2.5	0.2	-1.7	-1.5	-1.7	-3.1	-3.1
Illnesses of siblings	0.4	0.6	1.9	-0.5	0.1	-0.5	-1.4	-1.0	-0.9	-0.2
Neuroticism score	0.5	1.0	3.0	0.6	1.1	-0.8	0.8	1.7	0.1	0.8
Weight	0.3	1.4	8.0	-0.6	-0.5	-2.8	-0.9	-0.5	-0.1	-0.5
Impedance of arm (right)	1.1	5.0	12.8	-2.9	-0.5	0.8	-1.1	-2.3	-3.6	-2.6
Arm fat percentage (right)	0.4	1.6	5.2	1.4	0.9	-2.3	0.0	0.4	1.1	1.5
Trunk fat-free mass	0.2	1.3	2.1	-1.3	-1.5	-1.4	-1.5	-0.1	0.1	-1.2
Hip circumference	0.5	2.2	12.1	-0.0	-0.1	-3.5	-1.4	-0.8	0.8	0.0
Time employed in main current job	0.2	0.2	0.7	-0.4	-0.8	0.5	0.0	-0.0	-0.6	-0.1
Alcohol intake versus 10 years previously	0.8	1.2	4.1	-0.3	1.2	-0.4	0.1	-2.0	-1.1	-1.0
Father’s age at death	0.7	1.0	4.7	-0.4	-0.2	2.2	-0.4	0.5	-1.2	-0.1
Worrier / anxious feelings	0.8	1.6	3.7	-1.5	-0.7	-1.1	0.6	0.8	-1.9	-1.5
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	13.7	3.1	1.2	-2.1	1.6	2.0	3.7	2.7
Falls in the last year	1.1	1.4	3.0	1.2	1.0	-0.2	1.2	1.7	1.5	0.9
Hair/balding pattern: Pattern 3	0.9	1.3	4.1	-1.0	0.0	1.2	0.0	-1.2	-2.0	-1.0
Number of live births	1.2	1.7	8.0	0.2	-1.2	-1.5	-2.8	0.3	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	6.0	-2.4	0.4	0.7	-1.3	-1.2	-1.5	-2.4
Pulse rate	3.3	5.5	11.4	2.8	-1.1	0.4	2.6	1.6	3.4	3.0
Happiness	1.1	1.4	2.2	-1.1	1.3	1.5	0.8	-0.6	-1.2	-1.5
Noisy workplace	0.5	0.6	1.2	0.4	1.1	1.0	0.5	-0.0	0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.7	-1.3	1.2	-0.0	-1.1	-0.7	-1.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.1	-1.1	0.1	-0.3	-0.3	-1.2	-1.3
Mouth/teeth dental problems: Dentures	2.6	4.4	8.2	2.9	-0.1	-0.7	1.7	2.2	2.5	2.8
Asthma	1.9	3.8	8.5	2.6	-0.6	-1.9	-0.6	-0.3	2.7	2.9
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	6.9	2.4	0.4	-0.5	0.1	2.6	2.1	2.1
Medication: Cholesterol lowering	0.2	0.3	1.0	0.3	-0.7	0.6	0.0	1.0	-0.5	0.4
Depression (self-reported)	0.8	1.0	5.1	0.6	2.3	-0.1	-0.1	-0.0	0.6	0.9
Medication: Lansoprazole	0.9	1.0	2.9	0.3	-1.0	1.4	1.0	1.7	-0.1	0.5
Prospective memory result	0.6	0.7	2.8	0.1	-0.0	1.3	1.7	0.5	0.7	-0.0
Lung cancer (father)	0.9	1.1	2.5	-1.4	0.2	-0.6	0.7	-1.1	-1.1	-1.6
Illnesses of mother	0.8	0.9	4.0	-0.6	-0.0	-2.0	-1.1	0.9	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	10.1	-3.0	-0.1	1.0	-1.1	-1.4	-2.0	-3.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.8	-0.2	-0.0	1.3	0.7	-0.5	0.3	0.0
Impedance of arm (left)	1.5	7.1	17.7	-3.5	-0.1	0.4	-1.3	-2.8	-4.2	-3.2
Arm fat mass (right)	0.5	2.0	8.3	1.2	0.7	-2.9	-0.2	0.4	1.4	1.3
Trunk predicted mass	0.3	1.4	2.4	-1.3	-1.5	-1.4	-1.6	-0.1	0.0	-1.3
Standing height	2.6	25.8	52.9	-7.3	-3.3	-0.8	-3.6	-4.2	-6.2	-6.9
Length of working week for main job	1.5	1.7	5.0	-1.3	-0.2	0.3	0.7	-2.2	-1.7	-1.3
Exposure to tobacco smoke at home	0.7	0.8	1.7	0.9	-0.3	-0.9	-1.2	0.1	1.3	1.0
Breastfed as a baby	0.3	0.4	0.8	-0.2	0.9	0.6	0.8	-0.1	-0.9	-0.4
Tense / ‘highly strung’	0.1	0.2	0.8	-0.4	-0.3	0.6	-0.1	0.9	-0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	0.9	1.3	0.1	0.0	1.3	0.8	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	3.4	0.4	0.6	1.8	0.3	-0.0	1.2	0.2
Birth weight of first child	0.7	1.3	3.6	-0.8	1.9	1.0	0.2	-1.4	-0.3	-1.3
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.8	0.0	0.2	-0.8	-0.5	0.0	-0.5
Pulse wave reflection index	0.4	0.4	0.9	0.9	0.5	0.5	-0.2	0.9	0.7	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.5	1.4	-0.1	0.2	1.1	-0.1	0.3
Loud music exposure frequency	0.3	0.4	0.8	-0.4	0.5	-0.4	-0.5	-0.5	0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	11.2	-3.4	0.2	-0.8	-1.3	-1.7	-2.7	-3.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.0	-2.2	-0.9	0.9	-1.8	-0.7	-1.4	-1.9
Blood clot in the leg (DVT)	0.3	0.4	2.2	0.2	1.5	0.2	0.6	-0.1	0.1	0.2
Medication: Paracetamol	0.3	0.5	1.8	0.2	1.3	-0.7	0.7	-0.0	-0.9	0.1
Headache pain in last month	0.6	0.9	4.4	0.6	0.0	0.3	0.8	2.1	-0.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.3	1.3	1.4	-1.0	0.3	0.8	2.1	1.0
Glaucoma (self-reported)	0.7	0.8	1.8	-1.4	0.7	0.9	0.7	-0.6	-1.0	-1.0
Gout (self-reported)	1.5	2.0	4.3	-1.0	1.6	1.8	2.1	0.2	-1.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	0.4	-0.3	-1.4	-1.3	0.7	-0.3	0.1
Medication: Amlodipine	0.6	0.9	1.7	1.2	1.2	-0.4	1.3	0.5	0.1	1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.7	1.1	-0.7	-0.3	1.6	0.2	0.9	1.2
Birth weight	0.6	1.3	4.6	-1.0	-0.6	-2.1	-0.6	-1.3	-0.5	-1.0
Chronic bronchitis/emphysema (mother)	4.3	5.0	9.7	2.6	1.4	-0.4	0.7	2.5	3.1	3.0
High blood pressure (siblings)	0.7	1.0	4.8	-0.0	-2.2	0.1	0.7	1.2	-0.1	-0.0
Forced vital capacity (FVC), Best measure	1.5	5.6	13.4	-3.7	-0.5	1.1	-0.4	-2.0	-2.7	-3.6
Body fat percentage	0.3	1.1	5.9	0.5	0.6	-2.4	0.1	-0.7	0.2	0.8
Leg fat percentage (right)	0.4	1.6	3.5	1.4	0.7	-1.9	0.6	-0.4	1.2	1.8
Arm fat-free mass (right)	0.2	1.2	4.6	-0.7	-0.8	-2.1	-1.0	-0.5	0.7	-0.8
Exposure to tobacco smoke outside home	0.6	0.9	2.8	0.6	1.7	0.0	0.3	-1.0	1.2	0.5
Comparative body size at age 10	0.1	0.3	0.6	-0.7	-0.7	0.5	0.2	-0.3	0.3	-0.7
Number of full brothers	0.5	0.6	2.0	0.6	-1.4	0.9	0.6	-0.2	0.7	0.6
Worry too long after embarrassment	0.7	1.1	3.0	1.0	0.0	-1.7	0.4	1.4	0.7	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.0	0.6	0.6	0.6	0.4	1.0	0.3	0.3
Wheeze or whistling in the chest in last year	1.0	1.7	3.5	1.4	-1.6	-1.9	-0.3	0.8	1.2	1.4
Number of children fathered	0.6	0.7	3.2	-0.0	-1.8	0.5	-1.0	0.3	-0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	-1.2	-0.6	-0.9	-0.6	-0.4	-0.4	-1.4
Age at first live birth	1.3	2.3	3.8	-1.7	1.9	1.9	0.5	-0.0	-1.8	-1.6
Pulse wave peak to peak time	0.4	0.5	1.6	-0.3	-0.0	-1.3	-0.9	0.4	-0.8	-0.5
Health satisfaction	1.7	2.3	4.4	1.7	-0.2	-1.8	1.0	2.1	1.5	1.4
Shortness of breath walking on level ground	1.5	1.7	4.1	1.4	1.0	-1.4	2.0	0.2	1.1	1.3
Qualifications: College or University degree	1.9	6.0	9.7	-3.0	-1.7	-0.2	-3.1	-1.5	-3.0	-2.9
Eye problems/disorders: None of the above	0.6	0.7	1.7	1.0	0.3	-1.3	0.1	0.9	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	-0.4	-0.4	0.2	0.8	-1.2	0.2	-0.3
Emphysema/chronic bronchitis	1.2	1.3	3.4	0.7	-1.7	-1.9	-0.6	-0.3	0.9	1.2
Medication for pain relief, constipation, heartburn	1.1	1.8	6.6	-0.8	-0.3	2.6	1.6	-1.2	0.2	-1.0
Neck or shoulder pain in last month	1.7	2.4	4.0	1.9	1.4	0.3	2.0	1.4	1.8	1.4
Medication: Blood pressure	1.2	2.1	5.0	-1.6	-1.5	1.2	-0.1	-1.5	-2.2	-1.2
Angina (self-reported)	0.5	0.7	3.2	-0.6	0.0	-1.8	0.6	-0.7	-0.4	-0.3
Migraine (self-reported)	0.8	1.0	2.5	1.4	-0.5	0.4	0.8	0.6	1.2	1.6
Medication: Ibuprofen	1.3	1.5	4.6	1.7	0.4	0.0	0.2	2.2	1.2	1.3
Medication: Allopurinol	0.9	1.2	4.5	-0.9	0.7	1.4	0.5	-0.5	-2.1	-0.7
Medication: Omeprazole	0.3	0.4	2.1	0.3	0.1	-0.3	-1.4	0.4	-0.5	0.2
Medication: Seretide 50 evohaler	2.0	2.3	4.7	1.2	-1.2	-1.9	-0.9	0.3	2.2	2.0
Mean time to correctly identify matches	0.8	1.4	2.7	1.7	0.8	1.5	0.6	0.1	1.6	1.3
Heart disease (mother)	0.3	0.4	1.9	0.3	0.5	0.4	-0.4	-1.4	-0.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	0.9	-0.1	-1.2	-0.7	1.2	1.1	0.5
Whole body fat mass	0.3	1.1	6.9	0.3	0.3	-2.6	-0.1	-0.6	0.5	0.6
Leg fat mass (right)	0.4	1.6	7.2	0.9	0.2	-2.7	-0.0	-0.2	1.2	1.3
Arm predicted mass (right)	0.3	1.4	5.3	-0.9	-0.9	-2.3	-1.3	-0.6	0.5	-0.9
Pulse rate, automated reading	4.2	13.5	28.0	4.8	-1.6	-1.8	2.0	2.6	5.3	5.2
Alcohol intake frequency.	0.2	0.4	1.4	-0.5	0.4	-0.5	0.2	-0.3	-0.9	-1.2
Comparative height size at age 10	0.5	3.0	6.1	-2.0	-0.1	-2.5	-2.1	-0.8	-1.5	-1.9
Number of full sisters	0.5	0.6	2.3	0.1	-1.1	0.8	0.3	1.5	-0.1	0.3
Suffer from ‘nerves’	0.6	0.9	3.7	0.1	1.0	1.9	-0.4	1.0	-0.6	-0.2
Overall health rating	0.9	1.9	5.0	1.8	0.4	-2.2	0.9	0.7	1.4	1.4
Chest pain or discomfort	0.7	1.1	3.4	0.2	0.3	-1.8	-0.1	1.3	1.6	-0.0
Had major operations	0.8	0.9	1.5	0.9	0.6	1.2	0.8	1.2	0.8	1.0
Age at last live birth	0.6	0.9	2.2	-1.1	0.6	1.5	-0.3	-0.1	-1.2	-0.9
Family relationship satisfaction	0.6	0.8	4.4	0.5	-0.2	-0.2	0.3	2.1	0.8	0.2
Leg pain on walking	1.9	2.4	6.7	2.0	1.0	-0.7	0.6	2.6	1.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	-1.0	-0.5	1.6	0.8	-0.9	-1.4	-0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	0.1	-0.4	-1.2	-0.3	-0.4	-0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.9	0.4	1.0	0.4	-1.7	0.5	0.3	0.8
Medication: Aspirin	0.8	1.0	2.3	-0.5	-1.3	-1.5	-1.3	0.5	-0.9	0.1
Supplements: Vitamin C	2.2	2.6	5.0	2.1	-0.7	0.6	0.4	2.2	2.2	1.7
Knee pain experienced in last month	0.4	0.6	3.1	0.4	-0.8	0.4	0.3	1.8	0.5	0.3
Hypertension (Self-reported)	0.2	0.6	1.4	-0.8	-0.6	0.6	0.5	-0.7	-1.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	2.8	1.4	1.2	1.4	1.3	1.6	1.6	1.7
Illnesses of father: Heart disease	0.9	1.3	2.9	-0.9	-1.4	1.7	0.3	1.7	-0.6	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.6	0.3	0.5	0.1	0.3	0.9	1.0
Smoking status: Previous	1.0	1.5	3.1	1.3	1.0	-0.2	1.0	1.8	1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.5	-1.3	-0.8	0.4	-1.4	-1.2	-1.0	-1.6
Whole body fat-free mass	0.2	1.3	3.6	-0.9	-1.3	-1.9	-1.3	-0.1	0.4	-1.0
Leg fat-free mass (right)	0.2	1.3	5.8	-0.6	-1.0	-2.4	-1.1	0.3	0.5	-0.7
Arm fat percentage (left)	0.4	1.7	6.6	1.2	1.1	-2.6	0.1	0.2	0.8	1.3
Average weekly red wine intake	1.2	1.8	3.0	-1.5	-0.5	1.7	-1.2	-1.4	-1.1	-1.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.9	0.6	0.8	-2.0	-0.3	0.6	0.7	0.2
Mood swings	1.7	3.1	8.2	1.8	2.1	-0.8	0.3	2.9	1.2	1.9
Loneliness, isolation	0.6	0.9	2.8	-0.3	-0.8	0.1	1.7	1.4	-0.7	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	3.1	1.0	-0.3	-0.5	-1.8	0.3	0.9	0.5
Ever had bowel cancer screening	1.9	2.3	4.8	-1.8	0.2	-0.6	-0.6	-2.1	-1.6	-2.2
Diabetes diagnosed by doctor	0.5	0.8	2.5	1.3	0.3	-1.0	0.3	0.1	-0.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-0.3	-1.4	-1.3	-1.5	-0.4	-0.3	-0.5
Friendships satisfaction	0.3	0.4	0.7	0.6	-0.1	0.8	0.1	0.8	0.7	0.5
Qualifications: nursing, teaching	3.3	5.1	10.0	-3.1	-0.8	2.3	-0.8	-1.0	-3.0	-3.2
Commuting to job workplace: Walk	1.0	1.1	3.7	0.1	-1.9	0.0	-1.9	-0.3	-0.1	0.0
Eye problems/disorders: Cataract	0.5	0.6	3.6	-0.4	-1.9	0.6	0.0	0.1	0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.9	0.8	1.0	-2.6	-2.1	0.4	1.0	-0.2
Medication for cholesterol	0.9	1.4	3.2	1.1	0.6	1.0	1.2	1.6	1.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.2	0.0	1.8	-0.5	0.3	0.4	-0.0	0.5
Back pain experienced in last month	1.3	1.9	4.6	1.4	1.5	-0.1	0.2	2.2	1.7	1.3
Mineral and other dietary supplements	0.4	0.6	2.2	-0.5	-1.0	-0.7	-0.0	-1.5	-0.2	0.3
Breast cancer (self-reported)	4.3	5.2	8.2	-2.9	-1.9	-2.0	-2.6	-1.1	-2.3	-2.7
Asthma (self-reported)	2.0	4.1	9.2	2.7	-0.7	-1.6	-0.5	-0.3	2.9	3.0
Osteoporosis (self-reported)	0.5	0.7	3.3	-0.5	-0.1	0.2	0.9	-1.8	-0.4	-0.4
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.9	0.9	-0.9	0.4	-0.5	0.5	0.7
Medication: Aspirin	0.6	0.8	2.0	-0.9	-1.4	-0.8	-0.9	0.3	-1.0	-0.4
Medication: Gliclazide	0.6	0.6	2.0	-0.5	-1.4	0.1	0.1	-0.3	-1.4	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	4.7	-0.0	1.2	-2.2	0.1	0.4	-0.2	0.2
Smoking status: Current	1.4	2.2	4.4	1.5	-0.3	-1.1	-1.0	1.8	2.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	-0.3	1.5	0.2	0.9	-0.8	0.3	-0.6
Whole body water mass	0.2	1.3	4.4	-0.8	-1.3	-2.1	-1.3	-0.0	0.5	-0.9
Leg predicted mass (right)	0.2	1.3	5.9	-0.5	-1.0	-2.4	-1.0	0.3	0.6	-0.5
Arm fat mass (left)	0.5	2.2	8.6	1.3	0.7	-2.9	0.0	0.6	1.5	1.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.5	0.4	-0.3	0.4	-0.7	0.0	0.4
Average weekly champagne plus white wine intake	0.2	0.2	1.2	0.2	0.1	-0.1	-1.1	0.3	0.5	0.1
Miserableness	1.9	3.3	5.7	2.2	1.5	-0.6	0.1	2.3	2.4	2.1
Guilty feelings	1.0	1.4	2.9	1.3	1.3	-0.3	1.7	1.4	0.9	1.1
Wears glasses or contact lenses	3.3	3.8	5.9	2.4	0.5	2.0	1.6	2.0	2.0	2.4
Ever taken oral contraceptive pill	0.6	0.7	2.7	-0.4	-0.0	0.7	-1.6	0.4	-1.0	-0.5
Hearing aid user	0.5	0.6	1.8	-0.5	-0.2	1.4	-1.2	-0.4	-0.6	-0.4
Mother’s age at death	0.9	1.2	4.1	-0.8	-0.3	0.7	2.0	-0.1	-0.9	-1.4
Financial situation satisfaction	0.4	0.5	2.0	0.3	0.2	-0.1	1.4	0.8	0.6	0.0
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.8	1.4	0.3	0.5	-0.3	1.5	2.4	1.8
Commuting to job workplace: Public transport	1.0	1.2	2.6	-0.5	1.0	1.6	1.5	0.1	-0.9	-1.3
Eye problems/disorders: Glaucoma	1.1	1.3	3.7	-1.2	1.3	1.9	1.2	-0.5	-0.7	-0.6
Medication: Blood pressure	0.1	0.2	1.3	-0.1	0.3	-0.2	0.4	-0.4	-1.1	0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	1.1	-0.2	0.0	-0.8	1.3	1.0	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	0.5	0.8	1.4	0.4	1.5	0.3	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.0	0.8	0.2	0.5	0.5	0.1	-0.3
Medication: Bendroflumethiazide	1.7	2.5	7.8	-1.4	-1.1	-0.0	-0.9	-2.8	-2.0	-1.5
Medication: Paracetamol	0.7	1.0	3.8	-0.8	0.8	-0.7	0.2	-0.6	-1.9	-1.1
Medication: Lisinopril	1.7	2.2	4.3	-1.5	1.4	-0.1	2.0	-0.9	-2.1	-1.4
Medication: Atorvastatin	0.3	0.4	1.6	-0.5	-1.2	-0.2	-0.6	0.0	-0.8	-0.3
Illnesses of father: High blood pressure	0.4	0.5	2.0	-0.4	0.6	0.8	-1.4	0.2	0.5	-0.5
Alcohol drinker status: Never	0.7	0.9	3.8	-1.1	-0.1	-0.6	-0.2	-0.3	-1.9	-0.9
Ever smoked	2.0	3.5	5.7	2.0	0.7	-1.6	0.5	2.4	2.4	2.3
Basal metabolic rate	0.3	1.4	5.0	-0.9	-1.1	-2.2	-1.3	-0.2	0.2	-0.9
Leg fat percentage (left)	0.4	1.4	3.0	1.3	0.7	-1.7	0.7	-0.0	1.1	1.7
Arm fat-free mass (left)	0.2	1.2	4.2	-0.4	-1.4	-2.0	-1.1	-0.1	0.8	-0.4
Number of operations (self-reported)	1.4	2.1	3.8	1.9	0.3	1.9	1.3	1.0	1.5	1.5
Average weekly beer plus cider intake	0.7	1.0	5.3	0.4	-0.1	1.0	2.3	0.1	0.0	0.6
Irritability	2.2	3.7	10.4	2.3	1.0	0.4	0.9	3.2	2.2	1.9
Risk taking	0.8	1.2	4.9	0.1	-1.1	-0.1	-2.2	-0.3	1.4	-0.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	7.8	0.4	1.1	2.8	0.5	0.4	-0.3	0.7
Fractured/broken bones in last 5 years	0.9	1.1	2.7	1.6	1.1	0.9	0.8	0.4	1.2	1.0
Age started oral contraceptive pill	0.7	0.8	1.7	-0.9	1.0	0.5	0.7	-0.2	-1.3	-1.3
Diastolic blood pressure, automated reading	1.0	3.1	7.2	2.4	0.9	1.7	0.9	0.0	2.7	2.1
Ever depressed for a whole week	1.5	1.8	2.5	1.6	1.0	1.5	0.1	1.3	1.6	1.6
Unable to work because of sickness or disability	1.9	2.5	5.5	1.9	-0.3	-2.3	-0.5	1.1	2.1	1.6
Commuting to job workplace: Cycle	2.0	2.5	4.6	1.8	2.0	0.5	1.1	0.5	2.1	1.9
Myopia	0.9	1.3	3.3	1.2	-1.1	1.8	1.0	0.5	0.7	1.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.5	0.3	-0.2	-0.2	-1.6	0.9	0.9	0.3
Cholesterol lowering medication	0.5	0.7	2.8	-0.7	-1.7	-0.7	-0.5	0.3	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.1	-0.0	-0.4	-0.1	-1.4	0.0	-1.1	0.0
Pain experienced in last month	1.2	2.0	10.0	-0.8	0.0	0.5	-1.0	-3.2	-0.8	-1.1
Supplements: Calcium	1.6	1.8	3.0	-1.3	0.9	1.6	0.9	-0.9	-1.7	-1.6
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	-0.4	0.5	-0.6	-1.4	-1.3	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.2	-0.9	-1.1	-0.3	-0.1	-0.1	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.6	0.4	1.3	0.2	0.9	0.3	0.3	0.4
Heart disease (siblings)	2.9	3.5	6.7	2.2	1.1	0.5	2.2	1.3	2.6	2.2
Alcohol drinker status: Previous	0.4	0.5	1.7	-0.0	0.4	-1.1	0.0	1.3	-0.1	-0.6
Pack years of smoking	0.2	0.3	0.9	-0.2	0.7	-0.2	-0.2	-0.9	-0.7	0.3
Impedance of whole body	1.7	8.5	19.3	-3.7	-0.2	1.2	-1.2	-3.4	-4.4	-3.4
Leg fat mass (left)	0.4	1.5	6.7	0.9	0.4	-2.6	0.1	-0.1	1.2	1.1
Arm predicted mass (left)	0.3	1.4	4.5	-0.3	-1.4	-2.1	-1.1	-0.1	1.3	-0.3