TWAS hub - CBX6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1140	0.0440	4.8e-03	0.060	NA	0.086	NA	0.088	2.7e-05	NA	5.1e-07	NA	4.2e-07
2	GTEx	Nerve Tibial	0.1366	0.0520	2.1e-03	0.012	NA	0.057	NA	0.029	4.7e-02	NA	7.0e-05	NA	3.8e-03
3	GTEx	Whole Blood	0.0800	0.0310	4.9e-03	0.029	NA	0.027	NA	0.014	1.0e-03	NA	1.4e-03	NA	1.8e-02
4	YFS	Blood	0.1272	0.0261	2.8e-16	0.032	0.061	0.056	0.058	0.049	1.0e-10	3.6e-19	9.7e-18	2.1e-18	7.8e-16
5	TCGA	Bladder Urothelial Carcinoma	0.0830	0.0450	8.5e-03	0.005	0.005	0.006	NA	0.011	1.2e-01	1.1e-01	9.2e-02	NA	4.0e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0596	0.0279	4.1e-06	0.024	0.044	0.042	NA	0.043	8.8e-04	8.7e-06	1.4e-05	NA	1.3e-05
7	TCGA	Thyroid Carcinoma	0.1300	0.0820	3.1e-03	0.016	0.015	0.030	NA	0.024	1.0e-02	1.3e-02	5.6e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hearing difficulty/problems with background noise	6.0	9.6	19.2	4.4	2.0	2.2	1.8	1.4	3.9	4.3
Chronic bronchitis/emphysema (mother)	4.3	5.0	9.7	2.6	1.4	-0.4	0.7	2.5	3.1	3.0
Breast cancer (self-reported)	4.3	5.2	8.2	-2.9	-1.9	-2.0	-2.6	-1.1	-2.3	-2.7
Pulse rate, automated reading	4.2	13.5	28.0	4.8	-1.6	-1.8	2.0	2.6	5.3	5.2
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	13.7	3.1	1.2	-2.1	1.6	2.0	3.7	2.7
Pulse rate	3.3	5.5	11.4	2.8	-1.1	0.4	2.6	1.6	3.4	3.0
Qualifications: nursing, teaching	3.3	5.1	10.0	-3.1	-0.8	2.3	-0.8	-1.0	-3.0	-3.2
Wears glasses or contact lenses	3.3	3.8	5.9	2.4	0.5	2.0	1.6	2.0	2.0	2.4
Breast Cancer	3.2	7.6	12.7	3.3	3.6	3.3	2.5	1.2	1.4	3.1
Age when periods started (menarche)	3.1	7.6	15.9	-3.3	-2.4	-0.1	-2.8	-1.0	-4.0	-3.4
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	11.2	-3.4	0.2	-0.8	-1.3	-1.7	-2.7	-3.3
Verbal and Numeric Reasoning (VNR)	3.0	7.1	13.6	-3.0	-1.1	-2.2	-3.0	-1.6	-3.7	-3.2
Fed-up feelings	3.0	5.5	11.4	3.2	0.9	-0.5	1.2	2.2	3.4	3.1
Qualifications: None of the above	2.9	6.2	13.0	3.6	0.9	-1.4	0.9	1.8	3.3	3.6
Heart disease (siblings)	2.9	3.5	6.7	2.2	1.1	0.5	2.2	1.3	2.6	2.2
Ever had hysterectomy (womb removed)	2.7	3.1	6.3	-2.3	-1.0	-0.8	-1.4	-2.2	-1.1	-2.5
Chronotype (morning person)	2.6	6.0	15.4	-2.7	1.0	-0.9	-3.9	-1.3	-2.9	-2.8
Mouth/teeth dental problems: Dentures	2.6	4.4	8.2	2.9	-0.1	-0.7	1.7	2.2	2.5	2.8
Standing height	2.6	25.8	52.9	-7.3	-3.3	-0.8	-3.6	-4.2	-6.2	-6.9
Height	2.5	47.8	88.2	-9.4	-5.5	-0.2	-6.5	-5.2	-8.5	-8.7
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	6.9	2.4	0.4	-0.5	0.1	2.6	2.1	2.1
Schizophrenia vs Biploar Disorder	2.3	3.0	10.7	1.6	0.6	0.8	1.2	-1.0	3.3	2.0
Fluid intelligence score	2.3	4.7	9.8	-2.5	0.2	-1.7	-1.5	-1.7	-3.1	-3.1
Triglycerides	2.2	3.7	10.9	-1.8	-0.9	-1.8	-3.3	-1.0	-1.5	-2.0
Supplements: Vitamin C	2.2	2.6	5.0	2.1	-0.7	0.6	0.4	2.2	2.2	1.7
Irritability	2.2	3.7	10.4	2.3	1.0	0.4	0.9	3.2	2.2	1.9
Chronic bronchitis/emphysema (father)	2.1	2.5	6.1	2.0	0.3	0.8	2.5	0.3	2.0	1.5
Past tobacco smoking	2.1	3.9	6.8	-2.3	-1.0	1.1	-0.8	-2.5	-2.5	-2.6
Medication: Seretide 50 evohaler	2.0	2.3	4.7	1.2	-1.2	-1.9	-0.9	0.3	2.2	2.0
Asthma (self-reported)	2.0	4.1	9.2	2.7	-0.7	-1.6	-0.5	-0.3	2.9	3.0
Ever smoked	2.0	3.5	5.7	2.0	0.7	-1.6	0.5	2.4	2.4	2.3
Commuting to job workplace: Cycle	2.0	2.5	4.6	1.8	2.0	0.5	1.1	0.5	2.1	1.9
Intelligence (Savage-Jansen 2018)	1.9	5.8	14.8	-3.0	-0.7	-0.6	-1.9	-1.9	-3.9	-3.0
Prostate Cancer	1.9	2.6	9.5	-0.6	-3.1	-1.7	-1.9	-1.3	0.2	-0.5
Smoking Status	1.9	4.6	10.5	2.2	-0.3	-2.1	-0.9	3.2	2.0	2.7
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.7	1.5	1.0	0.4	1.7	2.4	2.1	1.5
Asthma	1.9	3.8	8.5	2.6	-0.6	-1.9	-0.6	-0.3	2.7	2.9
Qualifications: College or University degree	1.9	6.0	9.7	-3.0	-1.7	-0.2	-3.1	-1.5	-3.0	-2.9
Leg pain on walking	1.9	2.4	6.7	2.0	1.0	-0.7	0.6	2.6	1.7	1.1
Ever had bowel cancer screening	1.9	2.3	4.8	-1.8	0.2	-0.6	-0.6	-2.1	-1.6	-2.2
Miserableness	1.9	3.3	5.7	2.2	1.5	-0.6	0.1	2.3	2.4	2.1
Unable to work because of sickness or disability	1.9	2.5	5.5	1.9	-0.3	-2.3	-0.5	1.1	2.1	1.6
Hearing difficulty/problems: Yes	1.8	2.7	6.2	2.4	0.4	1.2	0.7	1.0	2.0	2.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.0	-2.2	-0.9	0.9	-1.8	-0.7	-1.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	2.8	1.4	1.2	1.4	1.3	1.6	1.6	1.7
Lupus	1.7	2.5	6.5	-1.2	0.1	-2.2	-0.5	-2.6	-1.4	-1.6
Blood White Count	1.7	12.7	33.5	3.0	5.8	3.9	3.8	0.3	2.6	3.1
Heel T-Score	1.7	13.5	32.0	4.8	-1.1	-0.9	1.5	2.2	5.5	5.7
Health satisfaction	1.7	2.3	4.4	1.7	-0.2	-1.8	1.0	2.1	1.5	1.4
Neck or shoulder pain in last month	1.7	2.4	4.0	1.9	1.4	0.3	2.0	1.4	1.8	1.4
Mood swings	1.7	3.1	8.2	1.8	2.1	-0.8	0.3	2.9	1.2	1.9
Medication: Bendroflumethiazide	1.7	2.5	7.8	-1.4	-1.1	-0.0	-0.9	-2.8	-2.0	-1.5
Medication: Lisinopril	1.7	2.2	4.3	-1.5	1.4	-0.1	2.0	-0.9	-2.1	-1.4
Impedance of whole body	1.7	8.5	19.3	-3.7	-0.2	1.2	-1.2	-3.4	-4.4	-3.4
Fasting Glucose	1.6	1.9	3.4	1.4	1.2	-1.2	-0.9	1.8	1.5	1.5
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.8	1.4	0.3	0.5	-0.3	1.5	2.4	1.8
Supplements: Calcium	1.6	1.8	3.0	-1.3	0.9	1.6	0.9	-0.9	-1.7	-1.6
Average weekly fortified wine intake	1.5	1.8	4.0	-1.3	-0.3	1.3	0.1	-2.0	-0.9	-2.0
Impedance of arm (left)	1.5	7.1	17.7	-3.5	-0.1	0.4	-1.3	-2.8	-4.2	-3.2
Length of working week for main job	1.5	1.7	5.0	-1.3	-0.2	0.3	0.7	-2.2	-1.7	-1.3
Gout (self-reported)	1.5	2.0	4.3	-1.0	1.6	1.8	2.1	0.2	-1.4	-1.1
Forced vital capacity (FVC), Best measure	1.5	5.6	13.4	-3.7	-0.5	1.1	-0.4	-2.0	-2.7	-3.6
Shortness of breath walking on level ground	1.5	1.7	4.1	1.4	1.0	-1.4	2.0	0.2	1.1	1.3
Ever depressed for a whole week	1.5	1.8	2.5	1.6	1.0	1.5	0.1	1.3	1.6	1.6
Respiratory disease	1.4	3.1	7.9	1.9	-1.0	-1.6	-0.7	-0.2	2.5	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	5.3	1.0	1.6	0.1	1.0	1.5	2.3	0.8
Relative age voice broke	1.4	2.2	9.0	-1.4	-0.1	1.1	0.7	0.8	-3.0	-1.4
Pain all over the body in last month	1.4	1.5	6.9	0.3	-1.7	-2.6	-0.1	0.6	0.1	0.3
Smoking status: Current	1.4	2.2	4.4	1.5	-0.3	-1.1	-1.0	1.8	2.1	1.7
Number of operations (self-reported)	1.4	2.1	3.8	1.9	0.3	1.9	1.3	1.0	1.5	1.5
Maternal smoking around birth	1.3	1.9	3.8	1.4	-0.5	0.8	0.6	1.6	1.9	1.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.1	0.8	2.3	0.3	-0.6	-1.6	1.3	0.6
Age at first live birth	1.3	2.3	3.8	-1.7	1.9	1.9	0.5	-0.0	-1.8	-1.6
Medication: Ibuprofen	1.3	1.5	4.6	1.7	0.4	0.0	0.2	2.2	1.2	1.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.9	0.8	1.0	-2.6	-2.1	0.4	1.0	-0.2
Back pain experienced in last month	1.3	1.9	4.6	1.4	1.5	-0.1	0.2	2.2	1.7	1.3
Alzheimer’s Disease (in mother)	1.2	1.4	3.3	1.6	-0.6	-0.8	0.6	0.8	1.8	1.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.9	-1.3	0.2	-1.5	-1.0	-1.0	-1.5	-1.7
Impedance of leg (right)	1.2	6.0	12.3	-3.1	-0.5	1.0	-1.0	-3.5	-3.3	-2.7
Impedance of leg (left)	1.2	5.9	11.5	-3.2	-0.6	1.1	-0.8	-3.1	-3.4	-2.7
Number of live births	1.2	1.7	8.0	0.2	-1.2	-1.5	-2.8	0.3	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	10.1	-3.0	-0.1	1.0	-1.1	-1.4	-2.0	-3.2
Emphysema/chronic bronchitis	1.2	1.3	3.4	0.7	-1.7	-1.9	-0.6	-0.3	0.9	1.2
Medication: Blood pressure	1.2	2.1	5.0	-1.6	-1.5	1.2	-0.1	-1.5	-2.2	-1.2
Average weekly red wine intake	1.2	1.8	3.0	-1.5	-0.5	1.7	-1.2	-1.4	-1.1	-1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	7.8	0.4	1.1	2.8	0.5	0.4	-0.3	0.7
Pain experienced in last month	1.2	2.0	10.0	-0.8	0.0	0.5	-1.0	-3.2	-0.8	-1.1
Alzheimer’s Disease (including proxy)	1.1	1.6	4.2	1.1	-0.8	-2.0	0.7	0.9	1.8	0.9
Schizophrenia (2014)	1.1	2.4	9.1	1.7	-1.0	-0.5	-1.5	-0.4	3.0	0.9
Blood Red Count	1.1	10.8	27.1	3.0	3.1	5.2	2.7	1.2	3.4	3.1
Relative age of first facial hair	1.1	2.3	6.7	-1.5	0.0	-0.6	-1.4	1.4	-2.6	-1.6
Current tobacco smoking	1.1	1.8	3.9	1.4	-0.5	-0.7	-0.9	1.7	2.0	1.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.2	-0.7	0.5	-1.8	-1.7	-1.1	0.1	-0.8
Serious illness, injury or assault to yourself	1.1	1.3	7.8	-0.2	-0.3	0.8	2.8	-0.4	0.1	-0.7
Body mass index (BMI)	1.1	4.8	8.5	2.7	1.0	-2.6	0.7	1.4	2.9	2.7
Hair/balding pattern: Pattern 2	1.1	1.4	4.4	0.3	2.1	-0.3	1.9	0.6	1.0	0.2
Forced vital capacity (FVC)	1.1	4.2	10.7	-3.3	-0.1	0.7	-0.6	-1.7	-2.2	-3.2
Impedance of arm (right)	1.1	5.0	12.8	-2.9	-0.5	0.8	-1.1	-2.3	-3.6	-2.6
Falls in the last year	1.1	1.4	3.0	1.2	1.0	-0.2	1.2	1.7	1.5	0.9
Happiness	1.1	1.4	2.2	-1.1	1.3	1.5	0.8	-0.6	-1.2	-1.5
Medication for pain relief, constipation, heartburn	1.1	1.8	6.6	-0.8	-0.3	2.6	1.6	-1.2	0.2	-1.0
Eye problems/disorders: Glaucoma	1.1	1.3	3.7	-1.2	1.3	1.9	1.2	-0.5	-0.7	-0.6
Reaction Time	1.0	1.9	4.4	2.0	1.5	0.9	0.2	-0.2	2.1	1.3
Crohns Disease (2012)	1.0	1.7	3.4	-1.8	0.8	0.6	-0.3	1.5	-1.7	-1.5
HbA1C	1.0	1.1	2.0	-1.3	0.7	1.2	-0.1	-0.5	-1.4	-1.3
HDL Cholesterol	1.0	1.6	4.6	1.5	-0.3	1.4	2.1	0.3	0.9	1.4
Neuroticism (2016)	1.0	1.4	4.9	1.3	0.6	-0.2	1.6	2.2	0.6	0.5
Lung FVC	1.0	4.9	9.4	-3.1	1.0	1.7	1.9	-1.7	-2.4	-2.9
Medication for hormone replacement therapy	1.0	1.1	3.3	-0.4	0.4	-1.2	-1.5	-1.8	-0.5	-0.2
Medication: Co-codamol	1.0	1.2	2.2	1.0	-0.2	-1.4	-1.5	1.4	1.0	0.6
Diabetes (mother)	1.0	1.3	3.2	1.0	1.8	0.9	1.6	-0.1	1.2	0.5
Medication: Atenolol	1.0	1.3	3.0	-1.7	-0.9	0.0	-0.5	-0.2	-1.7	-1.4
Had other major operations	1.0	1.2	3.1	0.9	0.3	1.4	1.7	-0.0	1.4	0.5
Wheeze or whistling in the chest in last year	1.0	1.7	3.5	1.4	-1.6	-1.9	-0.3	0.8	1.2	1.4
Smoking status: Previous	1.0	1.5	3.1	1.3	1.0	-0.2	1.0	1.8	1.1	1.5
Commuting to job workplace: Walk	1.0	1.1	3.7	0.1	-1.9	0.0	-1.9	-0.3	-0.1	0.0
Guilty feelings	1.0	1.4	2.9	1.3	1.3	-0.3	1.7	1.4	0.9	1.1
Commuting to job workplace: Public transport	1.0	1.2	2.6	-0.5	1.0	1.6	1.5	0.1	-0.9	-1.3
Diastolic blood pressure, automated reading	1.0	3.1	7.2	2.4	0.9	1.7	0.9	0.0	2.7	2.1
Schizophrenia (2018)	0.9	2.0	7.5	1.5	-0.6	-0.1	-1.8	-0.2	2.7	0.6
Alzheimer’s Disease (in father)	0.9	0.9	4.5	-0.9	-0.5	-2.1	-0.5	0.3	-0.3	-0.9
Rheumatoid Arthritis	0.9	1.2	4.0	-1.0	1.4	-0.1	0.0	-0.7	-2.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.7	1.5	0.5	1.4	1.4	-0.5	-0.7
Hair/balding pattern: Pattern 3	0.9	1.3	4.1	-1.0	0.0	1.2	0.0	-1.2	-2.0	-1.0
Medication: Lansoprazole	0.9	1.0	2.9	0.3	-1.0	1.4	1.0	1.7	-0.1	0.5
Lung cancer (father)	0.9	1.1	2.5	-1.4	0.2	-0.6	0.7	-1.1	-1.1	-1.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.3	1.3	1.4	-1.0	0.3	0.8	2.1	1.0
Medication: Allopurinol	0.9	1.2	4.5	-0.9	0.7	1.4	0.5	-0.5	-2.1	-0.7
Overall health rating	0.9	1.9	5.0	1.8	0.4	-2.2	0.9	0.7	1.4	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	-1.0	-0.5	1.6	0.8	-0.9	-1.4	-0.8
Illnesses of father: Heart disease	0.9	1.3	2.9	-0.9	-1.4	1.7	0.3	1.7	-0.6	-0.6
Medication for cholesterol	0.9	1.4	3.2	1.1	0.6	1.0	1.2	1.6	1.8	0.6
Mother’s age at death	0.9	1.2	4.1	-0.8	-0.3	0.7	2.0	-0.1	-0.9	-1.4
Fractured/broken bones in last 5 years	0.9	1.1	2.7	1.6	1.1	0.9	0.8	0.4	1.2	1.0
Myopia	0.9	1.3	3.3	1.2	-1.1	1.8	1.0	0.5	0.7	1.2
Depressed Affect (Nagel 2018)	0.8	1.8	5.0	1.3	1.1	-1.6	-0.1	2.2	0.6	1.2
Body Mass Index (BMI) (2010)	0.8	1.0	2.8	1.1	-0.8	-1.7	-0.9	1.0	0.7	0.7
Mean Putamen Volume	0.8	0.9	2.2	1.5	0.8	0.9	1.0	0.5	0.9	0.9
Type 2 Diabetes (T2D) (2012)	0.8	0.9	4.0	0.5	0.1	1.0	0.6	0.8	2.0	0.4
BMI	0.8	4.4	8.3	2.5	0.3	-2.4	1.0	2.0	2.9	2.2
Sensitivity / hurt feelings	0.8	1.4	3.9	0.9	-0.7	-2.0	-1.4	0.9	-0.0	1.5
Alcohol intake versus 10 years previously	0.8	1.2	4.1	-0.3	1.2	-0.4	0.1	-2.0	-1.1	-1.0
Worrier / anxious feelings	0.8	1.6	3.7	-1.5	-0.7	-1.1	0.6	0.8	-1.9	-1.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	6.0	-2.4	0.4	0.7	-1.3	-1.2	-1.5	-2.4
Depression (self-reported)	0.8	1.0	5.1	0.6	2.3	-0.1	-0.1	-0.0	0.6	0.9
Illnesses of mother	0.8	0.9	4.0	-0.6	-0.0	-2.0	-1.1	0.9	-0.1	-0.4
Migraine (self-reported)	0.8	1.0	2.5	1.4	-0.5	0.4	0.8	0.6	1.2	1.6
Mean time to correctly identify matches	0.8	1.4	2.7	1.7	0.8	1.5	0.6	0.1	1.6	1.3
Had major operations	0.8	0.9	1.5	0.9	0.6	1.2	0.8	1.2	0.8	1.0
Medication: Aspirin	0.8	1.0	2.3	-0.5	-1.3	-1.5	-1.3	0.5	-0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-0.3	-1.4	-1.3	-1.5	-0.4	-0.3	-0.5
Risk taking	0.8	1.2	4.9	0.1	-1.1	-0.1	-2.2	-0.3	1.4	-0.1
Depression (Nagel 2018)	0.7	1.1	5.6	0.4	0.7	-0.3	0.4	2.4	1.1	0.3
Ovarian Cancer	0.7	0.9	2.3	1.5	0.8	-0.4	-0.0	1.2	0.4	1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.5	-0.1	0.9	-1.1	-1.9	-0.3	-0.4	-0.7
Vitamin and mineral supplements	0.7	0.9	2.7	-1.0	-0.0	0.9	-0.4	-1.6	-1.2	-0.2
Mouth/teeth dental problems	0.7	1.0	1.9	-0.6	0.1	1.4	-0.5	-1.4	-1.4	-0.8
Medication: Simvastatin	0.7	1.0	2.3	-1.3	-1.2	-0.1	-0.6	-0.3	-1.5	-1.0
Father’s age at death	0.7	1.0	4.7	-0.4	-0.2	2.2	-0.4	0.5	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.1	-1.1	0.1	-0.3	-0.3	-1.2	-1.3
Exposure to tobacco smoke at home	0.7	0.8	1.7	0.9	-0.3	-0.9	-1.2	0.1	1.3	1.0
Birth weight of first child	0.7	1.3	3.6	-0.8	1.9	1.0	0.2	-1.4	-0.3	-1.3
Glaucoma (self-reported)	0.7	0.8	1.8	-1.4	0.7	0.9	0.7	-0.6	-1.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.7	1.1	-0.7	-0.3	1.6	0.2	0.9	1.2
High blood pressure (siblings)	0.7	1.0	4.8	-0.0	-2.2	0.1	0.7	1.2	-0.1	-0.0
Worry too long after embarrassment	0.7	1.1	3.0	1.0	0.0	-1.7	0.4	1.4	0.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	-1.2	-0.6	-0.9	-0.6	-0.4	-0.4	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	0.9	-0.1	-1.2	-0.7	1.2	1.1	0.5
Chest pain or discomfort	0.7	1.1	3.4	0.2	0.3	-1.8	-0.1	1.3	1.6	-0.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.9	0.6	0.8	-2.0	-0.3	0.6	0.7	0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	4.7	-0.0	1.2	-2.2	0.1	0.4	-0.2	0.2
Medication: Paracetamol	0.7	1.0	3.8	-0.8	0.8	-0.7	0.2	-0.6	-1.9	-1.1
Alcohol drinker status: Never	0.7	0.9	3.8	-1.1	-0.1	-0.6	-0.2	-0.3	-1.9	-0.9
Average weekly beer plus cider intake	0.7	1.0	5.3	0.4	-0.1	1.0	2.3	0.1	0.0	0.6
Age started oral contraceptive pill	0.7	0.8	1.7	-0.9	1.0	0.5	0.7	-0.2	-1.3	-1.3
Bipolar Disorder or Schizophrenia	0.6	1.5	3.7	1.2	-1.0	-0.7	-1.9	-0.2	1.9	0.5
Neuroticism (Nagel 2018)	0.6	1.3	3.9	1.0	0.3	-2.0	-0.2	1.9	0.0	0.8
Age at First Birth	0.6	0.9	2.6	-0.8	1.1	1.6	0.7	-0.9	0.0	-0.6
LDL Cholesterol	0.6	1.0	2.7	-1.4	-0.5	0.5	0.7	-0.8	-1.0	-1.6
Waist Hip Ratio (WHR)	0.6	2.9	7.8	2.0	-1.1	1.1	1.5	0.1	1.9	2.8
Cardiovascular Disease	0.6	1.9	4.5	-1.8	-1.4	-0.2	-0.5	-0.5	-1.6	-2.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	1.1	-0.4	-1.5	-1.1	-0.4	0.2	1.6
Angina	0.6	0.7	3.3	-0.6	0.3	-1.8	0.7	-0.7	-0.4	-0.5
Sitting height	0.6	4.3	9.0	-3.0	-2.2	-0.7	-0.7	-1.7	-2.4	-2.6
Waist circumference	0.6	2.4	5.5	1.8	0.2	-2.3	0.2	-0.2	1.7	2.2
Had menopause	0.6	0.7	2.1	0.7	1.5	1.3	0.6	-0.5	-0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	0.9	0.6	-0.0	0.7	-1.4	0.8	1.3
Prospective memory result	0.6	0.7	2.8	0.1	-0.0	1.3	1.7	0.5	0.7	-0.0
Headache pain in last month	0.6	0.9	4.4	0.6	0.0	0.3	0.8	2.1	-0.4	1.0
Medication: Amlodipine	0.6	0.9	1.7	1.2	1.2	-0.4	1.3	0.5	0.1	1.2
Birth weight	0.6	1.3	4.6	-1.0	-0.6	-2.1	-0.6	-1.3	-0.5	-1.0
Exposure to tobacco smoke outside home	0.6	0.9	2.8	0.6	1.7	0.0	0.3	-1.0	1.2	0.5
Number of children fathered	0.6	0.7	3.2	-0.0	-1.8	0.5	-1.0	0.3	-0.6	0.3
Eye problems/disorders: None of the above	0.6	0.7	1.7	1.0	0.3	-1.3	0.1	0.9	0.8	0.7
Suffer from ‘nerves’	0.6	0.9	3.7	0.1	1.0	1.9	-0.4	1.0	-0.6	-0.2
Age at last live birth	0.6	0.9	2.2	-1.1	0.6	1.5	-0.3	-0.1	-1.2	-0.9
Family relationship satisfaction	0.6	0.8	4.4	0.5	-0.2	-0.2	0.3	2.1	0.8	0.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.9	0.4	1.0	0.4	-1.7	0.5	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.5	-1.3	-0.8	0.4	-1.4	-1.2	-1.0	-1.6
Loneliness, isolation	0.6	0.9	2.8	-0.3	-0.8	0.1	1.7	1.4	-0.7	-0.2
Medication: Aspirin	0.6	0.8	2.0	-0.9	-1.4	-0.8	-0.9	0.3	-1.0	-0.4
Medication: Gliclazide	0.6	0.6	2.0	-0.5	-1.4	0.1	0.1	-0.3	-1.4	-0.4
Ever taken oral contraceptive pill	0.6	0.7	2.7	-0.4	-0.0	0.7	-1.6	0.4	-1.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	1.1	-0.2	0.0	-0.8	1.3	1.0	1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	0.5	0.8	1.4	0.4	1.5	0.3	-0.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	-0.4	0.5	-0.6	-1.4	-1.3	-0.2	-0.4
Ulcerative Colitis	0.5	0.7	1.1	-1.0	0.4	-0.6	-0.8	-0.5	-1.1	-1.1
Blood Platelet Count	0.5	5.6	30.7	0.6	5.5	-1.1	2.5	-1.0	0.1	-0.2
Allergy or Eczema	0.5	1.4	4.7	-1.4	0.1	0.5	1.0	-2.2	-0.9	-1.2
Neuroticism	0.5	1.3	1.9	1.0	1.4	-1.3	0.9	1.3	0.6	1.2
Supplements: Zinc	0.5	0.5	1.2	-0.7	-0.6	-0.5	-0.6	-0.3	-0.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	0.6	1.2	-0.2	-0.6	1.0	0.7	0.5
Supplements: Glucosamine	0.5	0.7	2.2	-0.3	-0.0	1.5	0.5	-0.1	-1.1	-0.9
High blood pressure (mother)	0.5	0.7	1.5	-0.6	0.1	1.2	-0.6	-1.0	-1.2	-0.7
Diabetes (self-reported)	0.5	0.7	1.7	1.2	-0.5	-0.8	-0.7	-0.5	-0.5	1.3
Neuroticism score	0.5	1.0	3.0	0.6	1.1	-0.8	0.8	1.7	0.1	0.8
Hip circumference	0.5	2.2	12.1	-0.0	-0.1	-3.5	-1.4	-0.8	0.8	0.0
Noisy workplace	0.5	0.6	1.2	0.4	1.1	1.0	0.5	-0.0	0.7	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.7	-1.3	1.2	-0.0	-1.1	-0.7	-1.1	-1.1
Arm fat mass (right)	0.5	2.0	8.3	1.2	0.7	-2.9	-0.2	0.4	1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	0.9	1.3	0.1	0.0	1.3	0.8	0.8
Number of full brothers	0.5	0.6	2.0	0.6	-1.4	0.9	0.6	-0.2	0.7	0.6
Angina (self-reported)	0.5	0.7	3.2	-0.6	0.0	-1.8	0.6	-0.7	-0.4	-0.3
Comparative height size at age 10	0.5	3.0	6.1	-2.0	-0.1	-2.5	-2.1	-0.8	-1.5	-1.9
Number of full sisters	0.5	0.6	2.3	0.1	-1.1	0.8	0.3	1.5	-0.1	0.3
Long-standing illness, disability or infirmity	0.5	0.8	3.1	1.0	-0.3	-0.5	-1.8	0.3	0.9	0.5
Diabetes diagnosed by doctor	0.5	0.8	2.5	1.3	0.3	-1.0	0.3	0.1	-0.1	1.6
Eye problems/disorders: Cataract	0.5	0.6	3.6	-0.4	-1.9	0.6	0.0	0.1	0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.2	0.0	1.8	-0.5	0.3	0.4	-0.0	0.5
Osteoporosis (self-reported)	0.5	0.7	3.3	-0.5	-0.1	0.2	0.9	-1.8	-0.4	-0.4
Arm fat mass (left)	0.5	2.2	8.6	1.3	0.7	-2.9	0.0	0.6	1.5	1.4
Hearing aid user	0.5	0.6	1.8	-0.5	-0.2	1.4	-1.2	-0.4	-0.6	-0.4
Cholesterol lowering medication	0.5	0.7	2.8	-0.7	-1.7	-0.7	-0.5	0.3	-0.9	-0.4
Crohns Disease (2017)	0.4	0.9	2.2	-0.8	0.5	-0.6	-0.8	1.5	-1.2	-0.8
Ulcerative Colitis (UC)	0.4	0.8	2.5	-0.5	0.3	-1.6	-0.9	-0.8	-0.8	-0.4
Primary Biliary Cirrhosis	0.4	0.6	1.8	-0.2	1.4	-1.2	-0.5	0.2	-0.5	0.0
Blood Eosinophil Count	0.4	3.4	6.7	2.3	2.1	0.6	0.9	1.1	2.6	2.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	1.0	-0.0	-0.6	-0.0	-0.1	-0.2	1.2
Townsend deprivation index at recruitment	0.4	0.5	2.7	-0.3	0.6	0.2	-0.2	-1.6	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	0.9	-0.4	0.8	0.8	-0.5	1.6	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.1	-0.6	0.2	0.9	0.4	-2.0	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.8	0.9	-0.6	0.1	0.3	-0.5	2.0	1.0
Illnesses of siblings	0.4	0.6	1.9	-0.5	0.1	-0.5	-1.4	-1.0	-0.9	-0.2
Arm fat percentage (right)	0.4	1.6	5.2	1.4	0.9	-2.3	0.0	0.4	1.1	1.5
Pulse wave reflection index	0.4	0.4	0.9	0.9	0.5	0.5	-0.2	0.9	0.7	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.5	1.4	-0.1	0.2	1.1	-0.1	0.3
Leg fat percentage (right)	0.4	1.6	3.5	1.4	0.7	-1.9	0.6	-0.4	1.2	1.8
Pulse wave peak to peak time	0.4	0.5	1.6	-0.3	-0.0	-1.3	-0.9	0.4	-0.8	-0.5
Leg fat mass (right)	0.4	1.6	7.2	0.9	0.2	-2.7	-0.0	-0.2	1.2	1.3
Knee pain experienced in last month	0.4	0.6	3.1	0.4	-0.8	0.4	0.3	1.8	0.5	0.3
Arm fat percentage (left)	0.4	1.7	6.6	1.2	1.1	-2.6	0.1	0.2	0.8	1.3
Mineral and other dietary supplements	0.4	0.6	2.2	-0.5	-1.0	-0.7	-0.0	-1.5	-0.2	0.3
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.9	0.9	-0.9	0.4	-0.5	0.5	0.7
Financial situation satisfaction	0.4	0.5	2.0	0.3	0.2	-0.1	1.4	0.8	0.6	0.0
Illnesses of father: High blood pressure	0.4	0.5	2.0	-0.4	0.6	0.8	-1.4	0.2	0.5	-0.5
Leg fat percentage (left)	0.4	1.4	3.0	1.3	0.7	-1.7	0.7	-0.0	1.1	1.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.1	-0.0	-0.4	-0.1	-1.4	0.0	-1.1	0.0
Alcohol drinker status: Previous	0.4	0.5	1.7	-0.0	0.4	-1.1	0.0	1.3	-0.1	-0.6
Leg fat mass (left)	0.4	1.5	6.7	0.9	0.4	-2.6	0.1	-0.1	1.2	1.1
Worry (Nagel 2018)	0.3	0.6	2.0	-0.7	-0.3	-0.4	-0.3	0.7	-1.4	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.5	-0.7	0.5	-1.2	-1.1	0.4	-1.1	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.7	0.3	0.3	1.4	0.0	-0.4	0.0
Medication: Metformin	0.3	0.4	1.0	0.9	-0.6	-0.8	-0.0	-0.1	-0.4	1.0
Trunk fat percentage	0.3	1.2	6.8	-0.3	0.4	-2.6	-0.4	-0.9	-0.4	0.0
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.7	0.2	-0.7	0.6	-0.4	-0.4	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.5	0.6	-0.1	-1.0	-0.6	1.2	-0.6	0.3
Leg predicted mass (left)	0.3	1.4	6.1	-0.5	-1.1	-2.5	-1.2	0.0	0.6	-0.6
Trunk fat mass	0.3	1.4	7.3	-0.7	0.1	-2.7	-0.6	-1.0	-0.7	-0.4
Alcohol usually taken with meals	0.3	0.5	2.0	-0.3	0.5	1.4	-0.4	0.1	-0.8	-0.1
Financial difficulties in last 2 years	0.3	0.4	2.1	0.4	0.1	0.4	1.5	0.2	0.3	0.1
Allergy	0.3	0.7	3.8	-0.4	-0.5	0.1	-0.2	2.0	-0.3	-0.5
Medication: Ramipril	0.3	0.4	0.9	-0.7	-0.9	0.9	0.5	-0.6	-0.2	-0.2
Weight	0.3	1.4	8.0	-0.6	-0.5	-2.8	-0.9	-0.5	-0.1	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.8	-0.2	-0.0	1.3	0.7	-0.5	0.3	0.0
Trunk predicted mass	0.3	1.4	2.4	-1.3	-1.5	-1.4	-1.6	-0.1	0.0	-1.3
Breastfed as a baby	0.3	0.4	0.8	-0.2	0.9	0.6	0.8	-0.1	-0.9	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	3.4	0.4	0.6	1.8	0.3	-0.0	1.2	0.2
Loud music exposure frequency	0.3	0.4	0.8	-0.4	0.5	-0.4	-0.5	-0.5	0.9	-0.7
Blood clot in the leg (DVT)	0.3	0.4	2.2	0.2	1.5	0.2	0.6	-0.1	0.1	0.2
Medication: Paracetamol	0.3	0.5	1.8	0.2	1.3	-0.7	0.7	-0.0	-0.9	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	0.4	-0.3	-1.4	-1.3	0.7	-0.3	0.1
Body fat percentage	0.3	1.1	5.9	0.5	0.6	-2.4	0.1	-0.7	0.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.0	0.6	0.6	0.6	0.4	1.0	0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	-0.4	-0.4	0.2	0.8	-1.2	0.2	-0.3
Medication: Omeprazole	0.3	0.4	2.1	0.3	0.1	-0.3	-1.4	0.4	-0.5	0.2
Heart disease (mother)	0.3	0.4	1.9	0.3	0.5	0.4	-0.4	-1.4	-0.0	-0.1
Whole body fat mass	0.3	1.1	6.9	0.3	0.3	-2.6	-0.1	-0.6	0.5	0.6
Arm predicted mass (right)	0.3	1.4	5.3	-0.9	-0.9	-2.3	-1.3	-0.6	0.5	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	0.1	-0.4	-1.2	-0.3	-0.4	-0.3	0.9
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.6	0.3	0.5	0.1	0.3	0.9	1.0
Friendships satisfaction	0.3	0.4	0.7	0.6	-0.1	0.8	0.1	0.8	0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	-0.3	1.5	0.2	0.9	-0.8	0.3	-0.6
Medication: Atorvastatin	0.3	0.4	1.6	-0.5	-1.2	-0.2	-0.6	0.0	-0.8	-0.3
Basal metabolic rate	0.3	1.4	5.0	-0.9	-1.1	-2.2	-1.3	-0.2	0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.6	0.4	1.3	0.2	0.9	0.3	0.3	0.4
Arm predicted mass (left)	0.3	1.4	4.5	-0.3	-1.4	-2.1	-1.1	-0.1	1.3	-0.3
Bipolar Disorder (2018)	0.2	0.4	1.0	-0.0	-1.0	-0.9	-0.7	-0.1	-0.3	0.0
Major Depression (MDD)	0.2	0.2	1.0	0.3	0.1	-0.2	-1.0	-0.1	0.3	-0.4
Systolic Blood Pressure	0.2	1.2	3.4	-0.8	-0.8	1.8	-0.4	-0.7	-1.1	-1.3
Hypothyroidism (self reported)	0.2	0.4	1.8	0.1	-0.4	-1.3	-0.4	0.8	-0.5	-0.1
Lung FEV1/FVC ratio	0.2	1.2	5.2	0.7	1.4	0.3	-2.3	1.0	0.0	0.1
Hand grip strength (left)	0.2	0.4	1.5	-0.1	1.2	0.9	0.1	-0.1	0.9	0.2
Number of treatments/medications taken	0.2	0.3	0.7	0.8	0.5	0.5	0.2	0.6	-0.1	0.9
Average weekly spirits intake	0.2	0.2	1.3	-0.1	0.0	1.2	0.3	-0.0	0.3	0.4
Systolic blood pressure, automated reading	0.2	0.6	2.7	0.5	0.2	1.6	-0.2	-1.2	0.0	0.0
Diabetes (father)	0.2	0.2	0.7	0.2	0.5	-0.8	0.1	0.0	-0.8	-0.1
Severe depression (siblings)	0.2	0.3	1.2	0.4	-0.4	-0.1	0.4	1.1	-0.3	0.3
Pack years adult smoking proportion	0.2	0.4	1.1	-0.3	0.5	-0.6	-0.5	-1.1	-0.7	0.3
Leg fat-free mass (left)	0.2	1.2	5.8	-0.4	-0.9	-2.4	-1.0	0.1	0.6	-0.5
High blood pressure	0.2	0.7	1.2	-0.6	-0.4	0.6	1.0	-0.9	-1.1	-0.9
Multivitamins +/- minerals	0.2	0.3	0.9	-0.2	-0.5	-0.9	0.6	0.0	-0.2	-0.8
Number of incorrect matches in round	0.2	0.4	1.1	-0.7	-0.3	-0.6	-0.4	0.0	-1.0	-0.7
Nervous feelings	0.2	0.4	1.0	-0.6	-0.6	-0.8	0.2	0.1	-1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.4	-0.2	-0.5	0.3	0.7	0.8	-0.1
Heart attack	0.2	0.2	0.7	-0.8	-0.8	-0.1	0.2	-0.1	-0.2	0.2
Trunk fat-free mass	0.2	1.3	2.1	-1.3	-1.5	-1.4	-1.5	-0.1	0.1	-1.2
Time employed in main current job	0.2	0.2	0.7	-0.4	-0.8	0.5	0.0	-0.0	-0.6	-0.1
Medication: Cholesterol lowering	0.2	0.3	1.0	0.3	-0.7	0.6	0.0	1.0	-0.5	0.4
Arm fat-free mass (right)	0.2	1.2	4.6	-0.7	-0.8	-2.1	-1.0	-0.5	0.7	-0.8
Alcohol intake frequency.	0.2	0.4	1.4	-0.5	0.4	-0.5	0.2	-0.3	-0.9	-1.2
Hypertension (Self-reported)	0.2	0.6	1.4	-0.8	-0.6	0.6	0.5	-0.7	-1.2	-1.0
Whole body fat-free mass	0.2	1.3	3.6	-0.9	-1.3	-1.9	-1.3	-0.1	0.4	-1.0
Leg fat-free mass (right)	0.2	1.3	5.8	-0.6	-1.0	-2.4	-1.1	0.3	0.5	-0.7
Whole body water mass	0.2	1.3	4.4	-0.8	-1.3	-2.1	-1.3	-0.0	0.5	-0.9
Leg predicted mass (right)	0.2	1.3	5.9	-0.5	-1.0	-2.4	-1.0	0.3	0.6	-0.5
Average weekly champagne plus white wine intake	0.2	0.2	1.2	0.2	0.1	-0.1	-1.1	0.3	0.5	0.1
Arm fat-free mass (left)	0.2	1.2	4.2	-0.4	-1.4	-2.0	-1.1	-0.1	0.8	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.5	0.3	-0.2	-0.2	-1.6	0.9	0.9	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.2	-0.9	-1.1	-0.3	-0.1	-0.1	-0.1	0.1
Pack years of smoking	0.2	0.3	0.9	-0.2	0.7	-0.2	-0.2	-0.9	-0.7	0.3
Hair Pigment	0.1	2.4	4.3	-1.3	1.3	1.8	2.1	0.5	-2.0	-1.4
Hand grip strength (right)	0.1	0.3	1.1	-1.0	-0.4	0.2	-0.5	-0.3	-0.3	-0.8
Taking other prescription medications	0.1	0.2	0.7	-0.0	0.8	0.0	0.6	0.2	-0.3	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.6	0.0	0.3	-0.8	-0.4	-0.1	0.0	-0.2
Tense / ‘highly strung’	0.1	0.2	0.8	-0.4	-0.3	0.6	-0.1	0.9	-0.5	-0.0
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.8	0.0	0.2	-0.8	-0.5	0.0	-0.5
Comparative body size at age 10	0.1	0.3	0.6	-0.7	-0.7	0.5	0.2	-0.3	0.3	-0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.5	0.4	-0.3	0.4	-0.7	0.0	0.4
Medication: Blood pressure	0.1	0.2	1.3	-0.1	0.3	-0.2	0.4	-0.4	-1.1	0.1
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.0	0.8	0.2	0.5	0.5	0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	-0.5	0.0
Tanning	0.0	0.3	1.1	-0.4	1.1	0.2	0.7	0.4	0.0	-0.4

Hub : Genes

CBX6

Models

Trait associations