Hub : Genes

APOBEC3F

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0210	1.9e-02	0.030	0.004	-0.001	0.008	0.015	0.00013	0.09800	0.40000	0.03300	0.00530
2	GTEx	Cells Transformed fibroblasts	0.1020	0.0370	1.5e-03	0.047	NA	0.041	NA	0.038	0.00020	NA	0.00049	NA	0.00072
3	GTEx	Esophagus Mucosa	0.1060	0.0380	7.4e-04	0.047	NA	0.045	NA	0.052	0.00040	NA	0.00055	NA	0.00023
4	NTR	Blood	0.0303	0.0110	5.6e-05	0.000	0.010	0.010	0.009	0.005	0.30000	0.00026	0.00025	0.00066	0.00520
5	TCGA	Prostate Adenocarcinoma	0.0198	0.0125	6.6e-03	0.016	0.015	0.009	NA	0.011	0.00760	0.00930	0.03500	NA	0.02300
6	TCGA	Thyroid Carcinoma	0.0290	0.0200	4.6e-03	0.016	0.020	0.016	NA	0.019	0.01100	0.00430	0.01000	NA	0.00490

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.0	4.8	5.8	2.2	-1.5	-2.4	2.2	2.3	-2.4
Bipolar Disorder or Schizophrenia	0.9	2.1	3.3	1.6	-0.7	-1.3	1.5	1.8	-1.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.8	1.7	-1.4	-0.9	0.1	1.2	-1.3
Depression (Nagel 2018)	0.1	0.2	0.3	0.4	-0.4	0.3	-0.6	0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.4	-1.0	-0.2	0.8	-1.2	-0.7	0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.4	0.5	-1.2	0.1	-0.6	0.2	-0.5
Schizophrenia (2018)	0.1	0.1	0.3	0.2	0.4	0.3	0.5	0.5	-0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	3.0	-0.8	1.7	1.4	-1.2	0.0	0.0
Worry (Nagel 2018)	0.2	0.4	1.6	0.5	-1.3	-0.3	0.1	0.3	-0.3
Alzheimer’s Disease (in mother)	9.0	10.5	13.1	-3.6	3.5	3.4	-1.2	-3.5	3.5
Alzheimer’s Disease (in father)	1.3	1.5	2.7	1.0	-1.5	-1.1	1.7	1.0	-0.6
Alzheimer’s Disease (including proxy)	1.6	2.4	4.5	-1.7	1.5	1.5	-0.0	-1.5	2.1
Crohns Disease (2017)	0.6	1.4	2.3	-1.3	1.2	1.0	0.1	-1.4	1.5
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.2	-0.3	-0.3	0.5	0.2	-0.2
Ulcerative Colitis (UC)	1.1	2.0	2.7	1.4	-1.6	-1.4	1.0	1.6	-1.4
Major Depression (MDD)	0.1	0.1	0.2	0.0	-0.5	0.4	-0.3	0.0	0.0
Reaction Time	1.9	3.6	4.3	1.9	-1.2	-2.0	2.1	2.0	-2.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.3	-1.8	0.4	1.6	-1.4	-1.7	1.3
Breast Cancer	0.1	0.3	0.6	-0.5	0.6	0.6	0.5	-0.8	-0.0
Ovarian Cancer	0.2	0.2	0.7	0.3	-0.8	0.3	-0.5	0.2	0.1
Prostate Cancer	0.2	0.3	0.6	-0.4	-0.7	0.7	-0.8	-0.3	0.5
Age at First Birth	0.2	0.3	1.0	-0.5	0.5	0.3	1.0	-0.6	0.2
Bipolar Disorder (2011)	0.7	0.6	3.1	0.2	-0.4	-0.7	1.8	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	1.7	-0.9	1.3	1.0	-0.7	-1.0	1.2
Coronary Artery Disease (CAD)	0.2	0.3	1.2	-0.5	0.2	0.3	1.1	0.0	0.0
Crohns Disease (2012)	0.6	0.9	2.4	-0.8	0.5	0.8	0.6	-1.0	1.5
Mean Putamen Volume	0.5	0.6	0.9	-1.0	0.9	0.8	-0.2	-0.7	0.7
Fasting Glucose	0.1	0.1	0.4	0.1	0.7	0.0	0.0	-0.2	0.6
HbA1C	1.1	1.2	4.0	2.0	-0.3	-0.9	0.6	1.1	-1.0
HDL Cholesterol	0.4	0.7	1.7	0.7	-0.0	-0.6	-0.6	1.1	-1.3
LDL Cholesterol	0.8	1.3	1.9	-1.1	1.4	1.2	-0.7	-1.3	1.1
Lupus	2.9	4.4	7.1	-2.1	1.9	2.7	-0.5	-2.3	2.3
Neuroticism (2016)	0.2	0.3	1.0	0.3	-0.3	-0.0	-0.7	0.4	-1.0
Primary Biliary Cirrhosis	4.3	6.1	8.1	2.8	-1.9	-2.7	2.4	2.8	-2.1
Rheumatoid Arthritis	2.1	2.9	6.6	1.5	-1.6	-1.4	2.6	1.5	-1.4
Schizophrenia (2014)	0.6	1.3	2.8	1.2	-0.7	-0.8	1.7	1.3	-0.8
Triglycerides	0.4	0.7	1.2	-0.8	-0.9	0.7	-0.6	-1.1	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	-0.1	1.1	0.7	-1.1	-0.5	0.9
Ulcerative Colitis	0.5	0.8	1.6	0.9	-1.3	-0.7	-0.1	0.9	-0.9
Blood Eosinophil Count	0.1	1.1	5.1	0.7	-0.6	-0.2	2.3	0.6	0.2
Blood Platelet Count	0.5	5.4	15.4	-1.8	2.2	1.7	0.6	-2.4	3.9
Blood Red Count	0.2	1.6	7.5	0.5	-0.8	-0.6	2.7	0.5	-0.7
Blood White Count	2.3	16.8	52.9	3.5	-3.4	-3.5	7.3	3.1	-1.5
Heel T-Score	0.3	2.0	4.0	-2.0	1.7	0.7	1.1	-1.2	1.4
BMI	0.2	1.3	3.6	1.0	-0.2	-0.5	-1.9	1.2	-1.3
Height	0.3	6.6	16.3	-2.2	-0.4	4.0	-0.9	-2.2	3.5
Waist Hip Ratio (WHR)	0.8	3.7	6.1	2.2	-0.6	-2.3	0.2	2.4	-2.5
Systolic Blood Pressure	0.1	0.5	2.4	0.2	-0.4	0.1	1.5	0.3	-0.2
Smoking Status	0.1	0.2	0.6	0.2	-0.3	-0.2	0.8	0.0	0.8
Allergy or Eczema	0.3	0.7	3.6	0.1	0.1	-0.5	-1.9	-0.0	-0.6
Cardiovascular Disease	0.1	0.4	1.8	0.3	-1.3	-0.2	0.8	0.4	-0.2
Hypothyroidism (self reported)	0.1	0.3	1.2	-0.4	-0.1	0.4	1.1	-0.4	-0.2
Respiratory disease	0.4	0.8	3.6	0.5	-0.9	-0.3	-1.9	0.4	-0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.2	0.2	0.1	-0.8	-0.4	0.3
Lung FEV1/FVC ratio	1.3	6.6	22.1	1.6	-2.4	-1.9	4.7	1.9	-1.3
Lung FVC	0.3	1.5	3.2	-0.9	1.8	1.0	-1.3	-1.2	0.8
Neuroticism	0.3	0.7	2.2	1.0	-1.5	-0.8	-0.1	0.5	-0.3
Chronotype (morning person)	0.5	1.2	3.9	0.7	-2.0	-0.9	1.3	0.5	-0.2
Hair Pigment	0.0	0.5	1.8	-0.2	0.6	0.4	-1.3	-0.6	0.4
Tanning	0.1	0.6	2.4	0.5	0.5	-0.5	1.6	0.6	-0.4
Hand grip strength (left)	0.1	0.3	0.4	-0.5	0.4	0.5	0.5	-0.4	0.6
Number of treatments/medications taken	0.4	0.8	1.6	0.6	-0.9	-0.4	-1.2	0.5	-1.3
Average weekly spirits intake	1.5	1.9	2.8	1.5	-1.2	-1.7	0.4	1.7	-1.4
Sensitivity / hurt feelings	0.1	0.2	1.1	0.2	-1.0	0.3	-0.4	0.0	-0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.4	-0.0	0.1	-0.3	0.4	-0.7
Hearing difficulty/problems: Yes	0.8	1.3	2.9	-0.8	1.3	1.2	-1.7	-1.0	-0.1
Relative age of first facial hair	0.1	0.1	0.3	0.3	-0.5	-0.3	-0.5	0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.3	1.0	-0.6	-1.0	-0.7	1.1	-1.5
Ever used hormone-replacement therapy (HRT)	2.7	3.4	6.0	2.0	-2.0	-1.2	-1.2	2.0	-2.4
Ever had hysterectomy (womb removed)	2.3	2.6	3.9	2.0	-1.9	-1.8	-0.2	1.8	-1.3
Systolic blood pressure, automated reading	0.1	0.4	1.9	-0.2	-0.6	0.0	1.4	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.3	-0.7	1.1	1.2	-0.6	-0.6	0.9
Angina	0.4	0.5	1.0	0.7	-1.0	-0.6	0.8	0.4	-0.4
Medication for hormone replacement therapy	0.4	0.4	1.2	0.1	-1.1	-0.0	-1.1	0.1	-0.5
Vitamin and mineral supplements	1.9	2.6	4.3	1.7	-2.1	-1.5	0.3	1.7	-1.8
Supplements: Zinc	0.0	0.0	0.2	-0.0	-0.1	0.1	0.1	-0.2	0.4
Medication: Co-codamol	0.1	0.1	0.2	0.4	-0.2	-0.3	0.2	0.3	0.3
Medication: Metformin	0.4	0.6	2.2	0.6	-1.5	-0.7	0.0	0.3	-0.5
Diabetes (father)	1.3	1.6	2.3	1.5	-1.0	-1.5	-0.5	1.5	-1.3
Diabetes (mother)	0.5	0.6	3.3	0.2	0.5	-0.3	-1.8	0.2	-0.3
Severe depression (siblings)	0.5	0.5	2.7	0.3	-0.2	-0.5	-1.6	0.3	0.2
Pack years adult smoking proportion	0.9	1.3	2.3	-1.4	0.8	0.9	0.3	-1.5	1.4
Impedance of leg (right)	0.3	1.3	7.1	-0.1	-0.6	-0.3	2.7	0.0	-0.3
Leg fat-free mass (left)	0.5	2.5	6.8	-0.9	0.6	2.1	-2.6	-0.8	1.5
Trunk fat percentage	0.5	2.0	3.7	1.8	-1.1	-1.0	0.1	1.9	-1.6
Hand grip strength (right)	0.2	0.5	0.8	-0.9	0.3	0.9	0.7	-0.6	0.6
Townsend deprivation index at recruitment	0.4	0.6	1.6	0.7	-1.3	-0.5	-0.9	0.6	-0.4
Current tobacco smoking	0.1	0.1	0.5	-0.1	-0.0	-0.1	0.7	-0.0	0.5
Average weekly fortified wine intake	0.9	1.1	2.0	1.3	-1.4	-1.0	0.9	0.8	-0.6
Maternal smoking around birth	0.1	0.2	1.0	-0.2	0.2	-0.1	-1.0	-0.2	0.2
Fed-up feelings	0.7	1.2	1.9	1.3	-1.4	-0.7	-0.2	1.1	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	1.1	-1.2	-0.2	0.5	0.8	-1.2
Relative age voice broke	0.1	0.2	0.4	-0.4	0.4	0.0	-0.4	-0.6	0.4
Taking other prescription medications	0.5	0.8	2.1	0.9	-0.5	-0.7	-1.5	0.7	-0.9
Age when periods started (menarche)	0.3	0.8	1.8	-0.8	0.1	1.0	0.8	-0.8	1.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.3	-0.4	-0.3	-0.9	0.3	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.6	0.6	-0.8	-1.0	1.3	0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.8	-1.3	1.3	1.2	-0.9	-1.2	0.3
Qualifications: CSEs or equivalent	1.1	1.5	2.2	-1.2	1.4	1.5	-1.3	-1.0	0.8
Serious illness, injury or assault to yourself	4.2	5.0	11.0	-2.3	3.3	2.6	-1.0	-2.1	1.4
High blood pressure	0.7	1.9	2.5	1.5	-1.6	-1.2	1.3	1.5	-1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.0	-0.3	0.1	0.0	-1.4	-0.6	0.3
Multivitamins +/- minerals	0.6	0.8	1.1	-0.9	1.0	0.8	-0.6	-1.0	1.0
Stomach or abdominal pain in last month	0.3	0.3	1.3	-0.1	0.4	0.4	-1.1	-0.2	0.4
Supplements: Glucosamine	0.1	0.1	0.4	0.3	0.7	0.0	-0.3	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	1.2	-0.8	-0.6	0.5	0.8	-1.0
Medication: Atenolol	1.4	1.7	5.0	0.8	-1.5	-1.1	2.2	0.8	-0.7
Medication: Levothyroxine sodium	0.3	0.6	0.8	-0.9	0.8	0.9	-0.6	-0.9	0.1
Sitting height	1.1	8.1	14.0	-3.0	1.8	3.7	-1.8	-2.8	3.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.1	1.5	0.1	-1.2	-0.0	0.2
High blood pressure (mother)	0.2	0.3	1.4	0.3	-1.2	-0.5	-0.0	0.1	0.0
Body mass index (BMI)	0.2	0.9	2.7	1.0	-0.3	-0.3	-1.6	1.1	-0.7
Impedance of leg (left)	0.2	1.2	6.9	-0.3	-0.2	-0.1	2.6	-0.2	-0.1
Leg predicted mass (left)	0.5	2.9	7.5	-1.0	0.6	2.2	-2.7	-0.9	1.6
Trunk fat mass	0.2	0.8	1.8	1.2	-0.8	-0.1	-0.7	1.3	-0.9
Waist circumference	0.3	1.1	1.8	1.3	-0.7	-0.4	-1.2	1.3	-1.1
Number of incorrect matches in round	0.2	0.3	0.7	0.2	-0.9	-0.3	-0.8	-0.0	-0.0
Past tobacco smoking	0.2	0.3	0.9	-0.9	-0.0	0.9	0.1	-0.6	0.0
Alcohol usually taken with meals	0.9	1.4	5.9	-0.3	1.1	0.7	-2.4	-0.7	0.5
Nervous feelings	0.2	0.5	1.1	-1.0	0.1	0.7	-0.1	-1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	0.2	-0.6	0.2	-0.3	0.1	-0.4
Hearing difficulty/problems with background noise	1.0	1.6	6.5	-0.7	2.5	1.1	-1.0	-0.8	0.4
Hair/balding pattern: Pattern 2	1.0	1.2	6.7	0.3	0.7	-0.3	-2.6	0.3	-0.4
Had menopause	4.1	5.1	6.8	2.4	-2.4	-2.4	0.8	2.6	-2.5
Had other major operations	1.0	1.2	2.3	1.1	-0.1	-0.8	-1.5	0.9	-1.5
Forced vital capacity (FVC)	2.9	11.3	15.5	-3.4	2.8	3.9	-2.3	-3.7	3.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.3	0.9	-1.1	-1.0	0.7	1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.6	-0.3	0.7	0.6	-1.6	-0.5	0.4
Qualifications: None of the above	1.5	3.3	3.8	1.8	-1.9	-1.9	1.8	1.9	-1.5
Financial difficulties in last 2 years	2.1	2.8	4.2	2.0	-1.9	-1.7	0.9	1.6	-1.7
Mouth/teeth dental problems	0.4	0.7	0.9	0.7	-0.8	-0.9	0.8	1.0	-0.9
Heart attack	0.6	0.8	1.4	-0.8	0.5	1.2	0.4	-1.0	1.2
Allergy	0.2	0.5	2.8	-0.1	0.3	0.3	1.7	0.1	0.3
Pain all over the body in last month	2.9	3.1	4.3	-1.8	0.7	2.0	-2.1	-1.7	1.9
Diabetes (self-reported)	0.4	0.7	2.2	0.6	-1.0	-0.7	-1.5	0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	5.4	2.0	-1.2	-2.2	0.2	2.1	-2.3
Medication: Ramipril	0.3	0.4	1.3	-0.5	-0.3	0.2	1.1	-0.6	0.3
Medication: Simvastatin	0.5	0.7	2.6	0.4	-1.6	-0.3	0.3	0.3	-1.0
Fluid intelligence score	2.4	5.1	6.1	-2.5	1.9	2.3	-1.9	-2.4	2.4
Illnesses of siblings	0.0	0.1	0.1	-0.3	0.2	0.3	0.3	-0.2	-0.1
Neuroticism score	0.7	1.5	3.6	1.4	-1.9	-1.1	-0.1	1.1	-1.2
Weight	0.2	1.2	4.3	-0.3	0.2	1.5	-2.1	-0.1	0.7
Impedance of arm (right)	0.7	3.3	10.6	1.2	-1.6	-1.4	3.3	1.0	-1.5
Arm fat percentage (right)	0.5	2.0	3.2	1.8	-1.2	-1.2	0.0	1.8	-1.7
Trunk fat-free mass	1.3	7.4	12.9	-2.5	1.5	3.6	-3.1	-2.4	2.8
Hip circumference	0.3	1.1	3.0	-0.3	-0.3	1.5	-1.7	-0.4	1.0
Time employed in main current job	1.2	1.3	2.2	0.9	-0.9	-1.4	1.5	0.9	-1.2
Alcohol intake versus 10 years previously	0.7	1.0	2.5	1.2	-1.6	-0.8	-1.1	0.6	-0.3
Father’s age at death	0.2	0.2	0.9	0.2	-0.3	-0.2	-0.3	0.5	-1.0
Worrier / anxious feelings	1.4	2.6	5.7	1.6	-2.4	-1.4	0.2	1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.7	0.3	0.8	-0.0	-0.2	0.1	-0.1
Falls in the last year	0.5	0.6	3.1	-0.4	0.4	0.6	-1.8	-0.3	-0.1
Hair/balding pattern: Pattern 3	0.7	1.1	2.6	0.8	-0.8	-1.0	1.6	0.7	-1.0
Number of live births	0.6	0.8	2.7	0.8	-1.7	-0.9	-0.1	0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	11.2	-2.9	2.3	3.3	-1.3	-3.1	3.2
Pulse rate	0.7	1.2	3.2	-1.2	1.8	0.8	-0.4	-1.0	0.9
Happiness	0.3	0.3	1.3	0.4	-0.7	-0.3	1.1	-0.3	0.1
Noisy workplace	0.5	0.6	1.2	1.1	-0.2	-0.9	-0.5	1.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.1	-1.1	1.0	1.0	-2.0	-1.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.3	-1.1	0.1	1.1	-0.9	-1.0	0.9
Mouth/teeth dental problems: Dentures	0.6	0.9	2.1	1.0	-0.7	-1.0	-0.4	1.0	-1.4
Asthma	0.5	0.9	2.5	0.7	-1.1	-0.6	-1.6	0.9	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	0.4	-0.4	-0.2	0.9	0.1	-0.3
Medication: Cholesterol lowering	0.3	0.4	1.5	0.3	-1.2	-0.1	0.1	0.2	-0.9
Depression (self-reported)	0.9	1.1	1.8	1.4	-0.1	-1.2	-0.5	1.3	-1.1
Medication: Lansoprazole	0.7	0.8	1.6	1.0	-0.5	-0.7	0.8	0.9	-1.3
Prospective memory result	0.9	1.1	3.1	0.9	-0.9	-1.1	1.8	0.6	-0.6
Lung cancer (father)	0.1	0.2	0.4	0.2	-0.5	-0.3	0.7	0.2	-0.3
Illnesses of mother	1.1	1.3	3.8	1.2	-0.8	-0.6	-0.0	1.3	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	5.2	-2.0	1.5	2.3	0.0	-2.2	2.3
Pulse wave Arterial Stiffness index	3.0	3.5	5.2	2.3	-1.2	-2.2	1.4	2.1	-1.7
Impedance of arm (left)	0.8	3.9	9.9	1.5	-1.7	-1.7	3.1	1.4	-1.8
Arm fat mass (right)	0.1	0.6	1.1	0.9	-0.5	-0.0	-1.1	1.0	-0.6
Trunk predicted mass	1.3	7.5	13.0	-2.6	1.5	3.6	-3.1	-2.4	2.8
Standing height	0.8	7.5	18.0	-2.9	1.1	4.2	-1.2	-2.5	3.1
Length of working week for main job	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.1	0.3	-0.3
Exposure to tobacco smoke at home	0.6	0.7	1.1	-0.7	1.1	0.8	-0.8	-0.8	0.6
Breastfed as a baby	0.7	0.8	4.0	0.5	-0.5	-0.3	2.0	0.3	0.4
Tense / ‘highly strung’	0.1	0.1	0.4	-0.4	-0.1	0.6	-0.3	-0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	4.5	2.1	-1.9	-1.8	0.1	2.1	-2.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.5	0.0	0.7	0.3	-0.1	-0.1	-0.1
Birth weight of first child	0.3	0.6	1.4	0.9	-0.5	-0.5	-1.2	0.8	-0.4
Peak expiratory flow (PEF)	0.7	1.6	2.8	-1.3	1.3	1.4	0.6	-1.1	1.7
Pulse wave reflection index	3.3	4.0	6.8	2.4	-1.5	-2.6	1.1	2.2	-1.8
Ever highly irritable/argumentative for 2 days	2.4	2.9	4.5	1.6	-2.1	-1.9	0.7	1.8	-1.8
Loud music exposure frequency	0.4	0.4	1.3	-0.5	0.3	0.1	-1.1	-0.6	0.7
Qualifications: O levels/GCSEs or equivalent	4.3	6.8	9.0	-2.7	2.3	3.0	-2.3	-2.6	2.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	-0.2	-0.9	0.0	1.0	-0.1	0.4
Blood clot in the leg (DVT)	0.9	1.2	1.9	-1.1	1.4	1.0	-1.0	-1.1	0.8
Medication: Paracetamol	0.2	0.4	0.9	0.9	-0.2	-0.4	-0.8	0.8	-0.3
Headache pain in last month	0.5	0.9	3.6	0.5	-0.6	-0.2	-1.9	0.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.1	-0.2	1.4	0.1	-0.9	-0.3	0.7
Glaucoma (self-reported)	0.1	0.1	0.4	0.6	-0.2	-0.4	0.3	0.2	-0.0
Gout (self-reported)	0.3	0.4	0.9	-0.7	1.0	0.8	-0.0	-0.7	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	-1.2	0.3	1.2	0.0	-1.2	0.6
Medication: Amlodipine	0.6	0.9	1.7	0.9	-0.8	-0.8	1.3	0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	1.0	-1.1	-0.9	-0.6	0.8	-0.4
Birth weight	1.0	2.2	4.1	-1.1	2.0	1.6	-1.6	-1.0	1.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.4	-0.9	1.9	0.6	-0.7	-0.6	0.9
High blood pressure (siblings)	0.1	0.2	0.6	-0.3	0.5	0.5	-0.8	-0.2	0.0
Forced vital capacity (FVC), Best measure	1.3	4.6	6.5	-2.2	1.8	2.6	-1.2	-2.5	2.4
Body fat percentage	0.4	1.7	3.1	1.7	-1.1	-0.9	-0.1	1.8	-1.6
Leg fat percentage (right)	0.3	0.9	1.7	1.2	-0.9	-0.8	-0.0	1.3	-1.0
Arm fat-free mass (right)	1.1	5.7	9.6	-2.0	1.6	3.0	-3.1	-1.7	2.5
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.5	0.2	-0.4
Comparative body size at age 10	0.3	0.9	3.2	-0.5	1.0	0.6	-1.8	-0.2	-0.6
Number of full brothers	0.9	1.1	2.9	-0.6	0.4	1.2	-1.7	-0.8	1.0
Worry too long after embarrassment	0.2	0.4	1.2	-0.4	0.2	0.5	-1.1	-0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	3.9	1.6	-1.4	-1.6	0.5	1.6	-2.0
Wheeze or whistling in the chest in last year	0.6	1.1	4.5	-0.9	0.3	0.9	-2.1	-0.6	0.3
Number of children fathered	3.3	3.7	7.1	-2.1	1.3	2.1	0.5	-2.1	2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.5	0.6	0.4	-0.6	-0.2	0.8
Age at first live birth	0.1	0.2	0.7	-0.2	0.4	0.5	0.4	-0.1	-0.9
Pulse wave peak to peak time	4.1	4.9	7.1	-2.6	1.5	2.7	-1.7	-2.5	2.0
Health satisfaction	0.8	1.0	2.0	-0.6	0.9	1.0	-1.1	-1.0	1.4
Shortness of breath walking on level ground	0.4	0.5	1.5	-0.4	0.9	0.6	-1.2	-0.4	0.3
Qualifications: College or University degree	0.1	0.2	0.8	-0.4	0.1	0.5	-0.9	-0.1	0.1
Eye problems/disorders: None of the above	0.4	0.5	0.7	0.4	-0.6	-0.8	0.6	0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.3	-0.1	0.4	-0.4	-0.5	0.1
Emphysema/chronic bronchitis	0.6	0.7	2.0	-0.7	0.1	0.8	-1.4	-0.5	0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.1	0.8	-0.2	-0.5	0.0	-0.3
Neck or shoulder pain in last month	0.8	1.2	4.6	-0.6	2.1	0.8	-0.8	-0.9	0.1
Medication: Blood pressure	0.5	0.9	1.8	0.8	-0.9	-0.5	1.0	0.9	-1.3
Angina (self-reported)	0.5	0.6	1.1	0.8	-1.1	-0.8	0.9	0.5	-0.6
Migraine (self-reported)	1.1	1.4	3.3	-1.0	1.2	1.0	-1.8	-1.0	0.9
Medication: Ibuprofen	0.2	0.3	0.5	0.7	-0.5	-0.4	0.1	0.4	-0.7
Medication: Allopurinol	1.0	1.3	2.5	-1.4	1.0	1.6	-0.4	-1.3	0.8
Medication: Omeprazole	0.7	0.9	1.7	1.3	-1.2	-0.8	0.5	1.1	-0.2
Medication: Seretide 50 evohaler	0.6	0.6	2.7	-0.2	0.7	0.5	-1.6	-0.1	0.6
Mean time to correctly identify matches	1.9	3.6	4.6	1.9	-1.3	-2.1	1.8	2.0	-2.1
Heart disease (mother)	1.7	2.1	3.4	1.5	-1.6	-1.8	1.1	1.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.6	0.8	0.6	-1.0	-0.6	1.0
Whole body fat mass	0.1	0.5	0.9	0.8	-0.5	0.2	-1.0	1.0	-0.6
Leg fat mass (right)	0.1	0.5	1.4	0.7	-0.4	0.1	-1.2	0.8	-0.2
Arm predicted mass (right)	1.3	6.6	12.4	-2.1	1.7	3.2	-3.5	-1.8	2.6
Pulse rate, automated reading	2.9	9.4	16.7	-3.3	4.1	2.9	-2.2	-2.8	2.9
Alcohol intake frequency.	0.4	1.0	3.0	1.0	-1.7	-0.9	-0.0	0.9	-0.5
Comparative height size at age 10	0.3	1.9	5.0	-1.5	0.9	2.2	-0.9	-1.2	1.1
Number of full sisters	0.1	0.1	0.5	0.3	-0.7	-0.1	-0.0	-0.2	0.4
Suffer from ‘nerves’	0.2	0.3	1.2	-0.3	-1.1	0.1	-0.5	-0.2	-0.4
Overall health rating	0.4	0.8	4.4	0.3	-0.2	0.1	-2.1	0.5	-0.5
Chest pain or discomfort	0.4	0.6	2.7	0.3	-0.2	-0.2	-1.6	0.5	-0.4
Had major operations	0.1	0.1	0.4	0.3	0.0	0.0	0.7	-0.0	-0.3
Age at last live birth	1.0	1.4	2.7	1.1	-1.6	-0.6	1.0	1.1	-1.4
Family relationship satisfaction	0.4	0.5	2.4	0.5	0.1	-0.4	-1.5	0.3	-0.6
Leg pain on walking	0.1	0.1	0.2	0.2	-0.5	-0.0	0.2	0.1	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.4	0.3	-0.6	0.7	-0.0	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.9	0.7	0.6	-0.9	0.3	1.2	-1.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	0.2	0.2	0.2	-0.3	0.5
Medication: Aspirin	0.2	0.3	0.8	-0.5	-0.9	0.7	-0.1	-0.4	0.4
Supplements: Vitamin C	0.4	0.4	1.5	-0.6	1.2	0.4	-0.4	-0.2	0.7
Knee pain experienced in last month	0.1	0.2	0.4	-0.4	0.3	0.6	-0.1	-0.4	0.4
Hypertension (Self-reported)	0.4	1.2	2.1	1.1	-1.4	-0.9	1.2	1.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.3	0.6	-0.4	-0.2	0.3	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.2	0.4	0.3	-0.6	-0.0	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.4	0.9	-0.7	-1.1	-0.5	1.2	-1.5
Smoking status: Previous	0.6	0.9	2.0	1.4	-0.8	-1.3	0.2	1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.1	-1.2	1.4	1.8	-1.7	-1.2	0.7
Whole body fat-free mass	1.0	5.5	9.6	-1.9	1.3	3.1	-3.1	-1.8	2.4
Leg fat-free mass (right)	0.6	3.4	8.4	-1.2	1.0	2.4	-2.9	-1.1	1.8
Arm fat percentage (left)	0.6	2.4	3.9	1.9	-1.2	-1.3	-0.1	2.0	-1.8
Average weekly red wine intake	1.0	1.5	2.8	1.7	-1.5	-1.3	0.2	1.4	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.0	-0.4	-0.3	0.6	0.1	0.2
Mood swings	2.3	4.1	5.2	2.3	-2.0	-2.0	1.2	2.2	-2.3
Loneliness, isolation	1.3	1.7	3.2	1.5	-1.6	-1.0	0.4	1.1	-1.8
Long-standing illness, disability or infirmity	0.3	0.5	2.2	0.0	-0.5	0.5	-1.5	-0.1	-0.4
Ever had bowel cancer screening	0.3	0.3	0.7	0.9	-0.4	-0.8	-0.2	0.7	-0.0
Diabetes diagnosed by doctor	0.3	0.5	2.9	0.3	-0.3	-0.3	-1.7	0.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.3	0.2
Friendships satisfaction	0.4	0.5	2.1	0.1	-0.6	0.1	-1.4	-0.1	-0.8
Qualifications: nursing, teaching	0.1	0.2	0.8	-0.1	0.3	0.3	0.2	-0.1	-0.9
Commuting to job workplace: Walk	0.5	0.5	1.8	-0.2	-0.7	0.6	-0.3	-0.5	1.4
Eye problems/disorders: Cataract	3.6	4.2	7.1	-1.9	1.9	2.1	-2.7	-1.8	1.7
Mouth/teeth dental problems: Mouth ulcers	3.1	5.0	10.2	-2.0	1.0	2.3	-1.6	-2.5	3.2
Medication for cholesterol	0.7	1.1	3.5	-0.7	1.9	0.5	0.5	-0.7	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	-0.4	1.0	0.1	0.7	-0.8	1.1
Back pain experienced in last month	0.2	0.2	0.6	-0.5	0.6	0.2	-0.3	-0.8	0.4
Mineral and other dietary supplements	0.8	1.1	3.0	0.8	-1.7	-0.7	0.9	0.9	-0.7
Breast cancer (self-reported)	1.9	2.3	4.2	1.6	-1.2	-1.6	-0.4	1.7	-2.0
Asthma (self-reported)	0.5	1.1	2.8	0.8	-1.1	-0.6	-1.7	1.0	-0.7
Osteoporosis (self-reported)	0.3	0.3	0.6	0.6	-0.2	-0.8	-0.1	0.5	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.4	0.6	0.3	-0.8	-0.4	0.5
Medication: Aspirin	0.2	0.3	0.8	-0.5	-0.9	0.7	0.2	-0.5	0.4
Medication: Gliclazide	0.6	0.7	1.9	0.4	-1.4	-0.1	-1.4	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.6	0.0	0.2	0.0	0.8	-0.2	0.3
Smoking status: Current	0.1	0.1	0.4	-0.2	0.0	0.1	0.7	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.1	-1.8	1.5	2.0	-0.2	-2.0	1.6
Whole body water mass	1.1	6.1	10.3	-2.1	1.4	3.2	-3.2	-2.0	2.5
Leg predicted mass (right)	0.7	3.8	8.6	-1.3	1.1	2.5	-2.9	-1.2	1.9
Arm fat mass (left)	0.2	0.9	2.0	1.0	-0.4	-0.1	-1.4	1.2	-0.7
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	0.8	-1.0	-0.5	-1.1	0.8	-1.2
Average weekly champagne plus white wine intake	0.4	0.5	1.5	-0.6	1.2	0.8	-0.7	-0.5	-0.0
Miserableness	0.9	1.5	2.6	1.6	-1.2	-1.1	0.5	1.4	-1.3
Guilty feelings	0.3	0.4	0.8	-0.5	-0.3	0.7	-0.9	-0.7	0.6
Wears glasses or contact lenses	0.3	0.4	1.1	0.5	0.1	-0.2	-0.3	0.8	-1.0
Ever taken oral contraceptive pill	1.4	1.6	3.9	1.2	-2.0	-1.1	0.9	1.0	-1.1
Hearing aid user	0.4	0.4	1.4	0.3	-1.2	-0.2	-0.3	0.3	-0.9
Mother’s age at death	0.6	0.7	2.2	0.7	-0.3	-0.5	-0.2	1.1	-1.5
Financial situation satisfaction	0.2	0.2	0.6	0.5	-0.1	-0.3	-0.5	0.2	-0.8
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.1	-0.9	0.3	0.7	-1.0	-1.2	1.4
Commuting to job workplace: Public transport	0.3	0.4	0.9	-0.4	0.1	0.7	-1.0	-0.7	0.7
Eye problems/disorders: Glaucoma	1.4	1.7	4.4	1.3	-0.8	-1.3	2.1	0.9	-0.9
Medication: Blood pressure	0.1	0.1	0.5	0.1	-0.7	-0.1	0.4	0.1	-0.3
Pain type(s) experienced in last month: Hip pain	2.1	2.6	4.1	2.0	-1.7	-1.7	1.3	1.9	-0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.9	-1.3	1.3	1.1	-0.2	-1.4	0.9
High cholesterol (Self-reported)	3.0	5.2	8.8	2.3	-3.0	-2.5	0.8	2.2	-2.3
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.7	0.0	0.8	-0.2	-0.6	0.4
Medication: Paracetamol	0.4	0.6	3.4	0.4	0.2	0.2	-1.8	0.4	0.0
Medication: Lisinopril	1.4	1.9	5.1	1.2	-0.9	-1.2	0.6	1.4	-2.3
Medication: Atorvastatin	1.0	1.3	3.5	1.1	-1.9	-1.0	-0.0	1.1	-0.8
Illnesses of father: High blood pressure	0.2	0.2	0.8	-0.4	-0.1	0.1	0.9	-0.3	0.6
Alcohol drinker status: Never	0.1	0.1	0.5	-0.4	0.1	0.2	-0.2	0.1	-0.7
Ever smoked	0.2	0.4	1.5	-0.0	1.2	-0.1	-0.5	-0.3	0.8
Basal metabolic rate	0.8	4.7	8.6	-1.7	1.1	2.9	-2.9	-1.5	2.1
Leg fat percentage (left)	0.2	0.9	1.8	1.3	-0.7	-0.8	-0.1	1.3	-0.9
Arm fat-free mass (left)	1.2	5.9	10.2	-2.0	1.5	3.2	-3.2	-1.8	2.4
Number of operations (self-reported)	0.1	0.2	0.5	0.7	-0.3	-0.2	-0.1	0.4	-0.7
Average weekly beer plus cider intake	0.3	0.4	1.0	-0.9	1.0	0.3	0.4	-0.6	0.2
Irritability	0.8	1.3	2.1	1.5	-1.2	-1.0	0.2	1.3	-1.2
Risk taking	0.2	0.3	0.4	0.7	-0.4	-0.6	-0.5	0.5	0.0
Ever had prostate specific antigen (PSA) test	2.8	3.3	8.6	1.8	-1.4	-1.8	2.9	1.4	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.4	0.6	0.9	-0.8	-0.5	0.5
Age started oral contraceptive pill	3.0	3.8	6.3	1.9	-1.7	-2.1	1.2	2.0	-2.5
Diastolic blood pressure, automated reading	0.1	0.2	0.8	-0.2	0.9	0.3	-0.0	0.2	-0.2
Ever depressed for a whole week	0.1	0.1	0.3	-0.2	-0.5	-0.0	0.1	-0.4	-0.0
Unable to work because of sickness or disability	1.6	2.0	5.0	-1.3	0.7	1.8	-2.2	-1.2	0.7
Commuting to job workplace: Cycle	0.4	0.5	1.2	-0.3	0.1	0.5	-1.0	-0.6	1.1
Myopia	4.3	6.2	9.5	-2.5	2.9	2.2	-3.1	-2.3	1.8
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.4	-1.3	1.6	1.0	-1.4	-1.3	1.1
Cholesterol lowering medication	1.1	1.6	4.2	1.1	-2.1	-0.9	-0.6	1.2	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	0.3	-0.7	0.2	0.5	0.0	0.7
Pain experienced in last month	0.4	0.7	1.0	0.9	-0.9	-1.0	0.8	0.8	-0.6
Supplements: Calcium	0.3	0.4	0.6	0.6	0.4	-0.8	-0.6	0.5	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	3.3	-0.1	0.7	0.8	-1.8	-0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.5	0.1	0.7	0.7	-0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.9	1.3	0.8	-0.8	-0.8	0.6
Heart disease (siblings)	0.3	0.4	1.4	-0.3	0.8	0.2	1.2	-0.3	0.5
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.1	-0.8	0.0	-0.3	-0.3	0.7
Pack years of smoking	0.4	0.6	1.2	-0.9	0.3	0.3	0.6	-1.1	1.1
Impedance of whole body	0.5	2.4	9.9	0.8	-1.1	-1.0	3.1	0.8	-1.0
Leg fat mass (left)	0.1	0.4	1.2	0.7	-0.3	0.1	-1.1	0.8	-0.2
Arm predicted mass (left)	1.3	6.5	11.3	-2.2	1.5	3.4	-3.2	-1.9	2.5