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chr2:218,296,003-220,733,584

Best TWAS P=1.44e-11 · Best GWAS P=6.52e-11 conditioned to 0.637

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
51	GTEx	Pituitary	PNKD	0.29	0.23	enet	21	0.24	8.9e-07	-6.0	6.8	1.4e-11	-0.83	0.01	0.98	TRUE
26	GTEx	Breast Mammary Tissue (Female)	USP37	0.16	0.00	enet	10	0.00	3.7e-01	-5.8	5.8	8.0e-09	-0.06	0.06	0.10	TRUE
47	GTEx	Nerve Tibial	SLC23A3	0.13	0.06	lasso	4	0.07	1.4e-05	-4.1	-5.2	2.2e-07	0.06	0.63	0.32	TRUE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM1	0.04	0.01	blup	49	0.02	4.8e-05	-6.5	6.7	2.7e-11	-0.95	0.01	0.98	FALSE
6	GTEx	Adipose Visceral Omentum	TMBIM1	0.17	0.03	enet	31	0.03	1.1e-02	-6.4	6.5	6.4e-11	-0.80	0.02	0.96	FALSE
19	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	-6.4	6.5	6.9e-11	-1.00	0.01	0.99	FALSE
75	YFS	Blood	GPBAR1	0.04	0.06	lasso	10	0.06	2.3e-18	-6.4	-6.5	7.6e-11	1.00	0.01	0.99	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	RP11-378A13.1	0.44	0.64	bslmm	431	0.64	1.1e-107	-6.4	6.5	8.0e-11	-0.98	0.01	0.99	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	RP11-378A13.1	0.47	0.51	lasso	5	0.48	1.5e-14	-6.4	-6.5	8.7e-11	1.00	0.01	0.99	FALSE
62	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	-5.3	6.4	1.4e-10	-0.95	0.04	0.96	FALSE
21	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	-6.5	6.4	1.8e-10	-0.97	0.01	0.99	FALSE
50	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	-6.5	6.4	2.0e-10	-0.97	0.01	0.99	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	RP11-378A13.1	0.37	0.37	enet	26	0.33	1.1e-12	-6.4	6.3	2.2e-10	-0.96	0.01	0.99	FALSE
36	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	-6.4	6.3	3.1e-10	-0.98	0.01	0.99	FALSE
66	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	-6.4	6.3	3.5e-10	-0.98	0.01	0.98	FALSE
18	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	-6.4	6.2	4.1e-10	-0.99	0.01	0.99	FALSE
45	GTEx	Muscle Skeletal	RP11-378A13.1	0.19	0.27	enet	23	0.31	1.7e-30	-6.4	6.2	4.1e-10	-0.97	0.01	0.99	FALSE
64	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	-6.4	6.2	4.9e-10	-0.97	0.01	0.99	FALSE
65	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	-6.4	6.2	5.0e-10	-0.97	0.03	0.83	FALSE
69	METSIM	Adipose	PNKD	0.07	0.08	lasso	7	0.08	4.8e-12	-6.0	6.2	5.7e-10	-0.90	0.07	0.93	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-378A13.1	0.30	0.28	enet	30	0.32	2.9e-17	-6.5	6.2	6.5e-10	-0.93	0.01	0.99	FALSE
46	GTEx	Nerve Tibial	ARPC2	0.29	0.30	enet	27	0.26	1.1e-18	-6.0	6.1	8.5e-10	-0.87	0.14	0.86	FALSE
38	GTEx	Heart Atrial Appendage	RP11-378A13.1	0.26	0.17	enet	13	0.22	2.0e-10	-6.5	6.1	8.7e-10	-0.97	0.01	0.99	FALSE
59	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	-6.1	6.1	8.7e-10	-0.88	0.04	0.91	FALSE
44	GTEx	Muscle Skeletal	ARPC2	0.23	0.17	enet	18	0.20	1.9e-19	-4.8	6.1	1.1e-09	-0.82	0.52	0.48	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	-6.5	6.1	1.3e-09	-0.96	0.01	0.99	FALSE
17	GTEx	Brain Cerebellum	RP11-378A13.1	0.46	0.52	enet	15	0.46	2.5e-15	-6.1	6.0	1.4e-09	-0.98	0.01	0.99	FALSE
35	GTEx	Esophagus Mucosa	RP11-378A13.1	0.28	0.32	enet	27	0.39	1.3e-27	-6.4	6.0	2.0e-09	-0.97	0.01	0.99	FALSE
31	GTEx	Cells Transformed fibroblasts	RP11-378A13.1	0.29	0.26	enet	24	0.31	2.0e-23	-5.3	6.0	2.3e-09	-0.95	0.06	0.94	FALSE
32	GTEx	Colon Sigmoid	RP11-378A13.1	0.31	0.33	enet	23	0.34	6.0e-13	-6.4	6.0	2.4e-09	-0.98	0.01	0.99	FALSE
15	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	-6.5	6.0	2.5e-09	-0.94	0.01	0.99	FALSE
39	GTEx	Heart Left Ventricle	TMBIM1	0.12	0.08	enet	11	0.07	1.4e-04	-5.8	6.0	2.6e-09	-0.96	0.02	0.98	FALSE
10	GTEx	Artery Aorta	TMBIM1	0.17	0.20	enet	29	0.19	1.2e-10	-4.9	5.9	2.8e-09	-0.91	0.02	0.98	FALSE
14	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	-6.0	5.9	2.9e-09	-0.94	0.07	0.93	FALSE
11	GTEx	Artery Aorta	RP11-378A13.1	0.28	0.28	enet	20	0.31	2.2e-17	-6.1	5.9	3.1e-09	-0.98	0.01	0.99	FALSE
41	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	-6.1	5.9	3.1e-09	-0.92	0.01	0.98	FALSE
61	GTEx	Stomach	RP11-378A13.1	0.32	0.32	enet	20	0.34	3.4e-17	-5.3	5.9	3.2e-09	-0.94	0.08	0.92	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM1	0.02	0.01	blup	49	0.02	2.6e-03	-5.1	5.9	3.2e-09	-0.95	0.02	0.92	FALSE
25	GTEx	Breast Mammary Tissue (Male)	RP11-378A13.1	0.27	0.24	enet	29	0.27	5.4e-07	-5.3	5.9	3.3e-09	-0.84	0.04	0.91	FALSE
23	GTEx	Brain Putamen basal ganglia	RP11-378A13.1	0.35	0.28	enet	18	0.29	1.2e-07	-6.4	5.9	3.8e-09	-0.98	0.01	0.98	FALSE
43	GTEx	Lung	RP11-378A13.1	0.27	0.30	enet	19	0.37	2.3e-29	-4.8	5.9	4.2e-09	-0.97	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	PNKD	0.11	0.00	enet	31	0.00	2.3e-01	-6.0	5.9	4.5e-09	-0.65	0.02	0.85	FALSE
63	GTEx	Thyroid	PNKD	0.13	0.12	enet	13	0.14	6.3e-11	-6.0	5.8	5.3e-09	-0.83	0.18	0.82	FALSE
28	GTEx	Breast Mammary Tissue (Female)	RP11-378A13.1	0.30	0.11	lasso	10	0.22	3.0e-07	-5.3	5.8	5.5e-09	-0.94	0.07	0.92	FALSE
1	GTEx	Adipose Subcutaneous	PNKD	0.12	0.08	lasso	3	0.07	4.2e-06	-5.3	5.8	5.9e-09	-0.94	0.19	0.81	FALSE
9	GTEx	Adrenal Gland	RP11-378A13.1	0.25	0.22	enet	17	0.30	3.2e-11	-4.9	5.8	6.1e-09	-0.95	0.03	0.97	FALSE
24	GTEx	Breast Mammary Tissue	RP11-378A13.1	0.27	0.26	enet	20	0.30	1.3e-15	-5.3	5.8	6.1e-09	-0.96	0.08	0.92	FALSE
33	GTEx	Colon Transverse	RP11-378A13.1	0.35	0.31	lasso	6	0.43	4.6e-22	-4.9	5.8	6.1e-09	-0.96	0.04	0.96	FALSE
4	GTEx	Adipose Subcutaneous	RP11-378A13.1	0.25	0.34	lasso	9	0.37	2.4e-31	-4.9	5.8	8.3e-09	-0.96	0.22	0.78	FALSE
74	YFS	Blood	AAMP	0.02	0.02	lasso	3	0.01	4.1e-05	-5.8	5.8	8.7e-09	-0.87	0.12	0.86	FALSE
40	GTEx	Heart Left Ventricle	RP11-378A13.1	0.21	0.16	enet	27	0.19	1.3e-10	-4.9	5.8	9.0e-09	-0.94	0.01	0.99	FALSE
27	GTEx	Breast Mammary Tissue (Female)	ARPC2	0.12	-0.01	lasso	5	-0.01	7.1e-01	-4.7	5.7	1.0e-08	-0.87	0.06	0.37	FALSE
52	GTEx	Pituitary	TMBIM1	0.20	0.16	enet	13	0.02	8.4e-02	-6.4	5.7	1.2e-08	-0.98	0.02	0.95	FALSE
49	GTEx	Pancreas	PNKD	0.12	0.10	lasso	3	0.08	3.6e-04	-6.0	5.7	1.4e-08	-0.85	0.05	0.74	FALSE
12	GTEx	Artery Coronary	RP11-378A13.1	0.34	0.36	lasso	8	0.38	1.2e-13	-4.9	5.7	1.5e-08	-0.93	0.05	0.95	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	-5.0	5.6	1.7e-08	-0.89	0.08	0.92	FALSE
58	GTEx	Skin Sun Exposed Lower leg	RP11-378A13.1	0.29	0.36	enet	28	0.40	9.8e-35	-5.0	5.6	1.8e-08	-0.96	0.19	0.81	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF142	0.06	0.05	enet	11	0.05	3.1e-06	-5.8	-5.6	2.1e-08	0.09	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	ARPC2	0.16	0.16	enet	12	0.17	4.4e-14	-6.0	5.6	2.3e-08	-0.86	0.13	0.87	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCD4	0.10	0.09	blup	61	0.09	1.6e-10	-5.8	-5.6	2.5e-08	0.05	0.01	0.99	FALSE
68	METSIM	Adipose	AAMP	0.03	0.00	bslmm	433	0.01	7.1e-03	-4.7	5.6	2.8e-08	-0.73	0.10	0.72	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	-4.9	5.5	3.0e-08	-0.93	0.03	0.97	FALSE
60	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	-5.0	5.5	3.2e-08	-0.91	0.20	0.80	FALSE
2	GTEx	Adipose Subcutaneous	TMBIM1	0.12	0.08	lasso	5	0.10	2.9e-08	-5.3	5.5	3.5e-08	-0.89	0.39	0.61	FALSE
42	GTEx	Lung	ARPC2	0.19	0.10	lasso	7	0.09	1.6e-07	-5.8	5.5	3.9e-08	-0.88	0.07	0.93	FALSE
48	GTEx	Nerve Tibial	RP11-378A13.1	0.33	0.31	enet	35	0.36	1.0e-26	-6.3	5.5	4.1e-08	-0.96	0.01	0.99	FALSE
8	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	-4.9	5.5	4.2e-08	-0.84	0.15	0.80	FALSE
67	GTEx	Whole Blood	RP11-378A13.1	0.11	0.13	enet	18	0.15	1.6e-13	-5.0	5.5	4.2e-08	-0.89	0.61	0.39	FALSE
70	METSIM	Adipose	TMBIM1	0.14	0.15	lasso	11	0.14	1.3e-20	-5.3	5.5	4.2e-08	-0.90	0.79	0.21	FALSE
57	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	-4.9	5.4	5.4e-08	-0.88	0.64	0.36	FALSE
76	YFS	Blood	PNKD	0.08	0.07	lasso	6	0.09	2.9e-27	-4.3	5.4	8.3e-08	-0.83	0.78	0.22	FALSE
13	GTEx	Artery Tibial	TMBIM1	0.18	0.14	enet	30	0.13	3.2e-10	-5.3	5.4	8.5e-08	-0.87	0.47	0.53	FALSE
53	GTEx	Pituitary	RP11-378A13.1	0.64	0.52	enet	19	0.52	2.7e-15	-6.5	5.3	1.4e-07	-0.95	0.01	0.99	FALSE
56	GTEx	Skin Sun Exposed Lower leg	ZNF142	0.10	0.05	enet	26	0.07	1.5e-06	-5.8	-5.2	1.6e-07	0.03	0.33	0.56	FALSE
71	NTR	Blood	CXCR1	0.03	0.03	lasso	8	0.03	1.1e-08	5.2	5.2	1.6e-07	-0.72	0.90	0.10	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	TMBIM1	0.35	0.24	lasso	10	0.24	2.3e-08	-5.3	5.2	1.7e-07	-0.89	0.76	0.24	FALSE
37	GTEx	Heart Atrial Appendage	TMBIM1	0.11	0.09	lasso	2	0.08	1.8e-04	-4.9	5.2	2.7e-07	-0.86	0.19	0.76	FALSE
72	NTR	Blood	CXCR2	0.03	0.02	lasso	2	0.02	2.9e-06	-5.1	5.2	2.7e-07	-0.73	0.53	0.46	FALSE
30	GTEx	Cells EBV-transformed lymphocytes	RP11-378A13.1	0.18	0.14	lasso	6	0.13	4.6e-05	-5.0	5.1	3.0e-07	-0.88	0.11	0.73	FALSE
20	GTEx	Brain Hippocampus	RP11-378A13.1	0.43	0.24	lasso	5	0.15	2.4e-04	-6.5	-5.1	3.1e-07	0.84	0.02	0.96	FALSE