Hub : Genes

PLCD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0190	2.4e-10	0.087	0.086	0.062	0.083	0.073	9.3e-11	1.3e-10	4.7e-08	2.9e-10	3.1e-09
2	GTEx	Artery Aorta	0.1380	0.0440	3.7e-08	0.180	NA	0.166	NA	0.184	3.6e-10	NA	1.8e-09	NA	2.1e-10
3	GTEx	Artery Coronary	0.1320	0.0590	2.6e-03	0.024	NA	-0.005	NA	0.017	5.1e-02	NA	5.5e-01	NA	8.5e-02
4	GTEx	Artery Tibial	0.0726	0.0322	2.2e-04	0.023	NA	0.028	NA	0.034	6.2e-03	NA	2.5e-03	NA	9.9e-04
5	GTEx	Brain Cerebellar Hemisphere	0.1170	0.0560	8.5e-03	0.150	NA	0.014	NA	0.066	1.1e-04	NA	1.4e-01	NA	8.9e-03
6	GTEx	Cells Transformed fibroblasts	0.2090	0.0470	8.8e-13	0.105	NA	0.236	NA	0.239	2.7e-08	NA	1.2e-17	NA	6.9e-18
7	GTEx	Liver	0.2430	0.1180	4.0e-04	0.148	NA	0.096	NA	0.154	6.6e-05	NA	1.2e-03	NA	4.5e-05
8	GTEx	Thyroid	0.0760	0.0390	3.2e-04	0.102	NA	0.083	NA	0.102	3.4e-08	NA	6.1e-07	NA	3.5e-08
9	ROSMAP	Brain Pre-frontal Cortex	0.0536	0.0205	6.1e-07	0.043	0.059	0.051	0.057	0.038	2.5e-06	4.6e-08	3.7e-07	7.0e-08	9.2e-06
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.1001	0.0466	8.1e-10	0.094	0.092	0.085	NA	0.091	1.0e-10	1.6e-10	7.6e-10	NA	2.1e-10
11	TCGA	Brain Lower Grade Glioma	0.0335	0.0301	1.9e-03	0.015	0.020	0.016	NA	0.017	6.2e-03	2.1e-03	5.2e-03	NA	3.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.3	0.5	1.1	-1.1	-0.7	-0.9	-0.5	-0.7	-0.6	0.5	0.5	-0.9	-0.4	-0.8
Bipolar Disorder or Schizophrenia	0.4	1.1	2.8	-1.2	-1.1	-0.9	-0.8	-1.0	-0.6	1.0	1.1	-1.7	-0.1	-1.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	-0.8	-0.9	-1.2	-0.6	-0.9	-1.1	0.5	0.7	-1.6	-0.9	-0.8
Depression (Nagel 2018)	0.5	0.7	1.2	-0.7	-0.9	-0.8	-0.7	-0.9	-0.2	1.0	1.1	-1.0	0.2	-1.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	7.3	1.4	0.6	-0.6	0.8	0.6	-1.6	-1.6	-1.1	0.6	-2.7	1.4
Neuroticism (Nagel 2018)	0.3	0.6	1.4	1.0	0.7	-0.1	1.2	0.7	-0.4	-1.0	-0.7	-0.1	-1.0	0.8
Schizophrenia (2018)	0.3	0.6	2.1	-0.8	-0.9	-0.5	-0.6	-0.7	-0.2	0.9	1.0	-1.5	0.1	-0.7
Schizophrenia vs Biploar Disorder	0.6	0.7	1.6	0.6	0.9	1.3	0.8	0.9	1.1	-0.6	-0.5	0.4	1.1	0.8
Worry (Nagel 2018)	0.5	1.0	2.0	1.4	0.8	-0.1	1.4	0.8	-0.4	-1.2	-0.9	0.8	-1.2	1.1
Alzheimer’s Disease (in mother)	2.2	2.5	4.2	1.6	1.7	1.7	1.9	1.7	1.1	-1.6	-1.4	2.1	0.7	1.7
Alzheimer’s Disease (in father)	1.1	1.2	2.3	-1.5	-1.1	-0.5	-1.3	-1.1	-0.2	1.3	1.4	-0.8	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.1	0.5	0.8	0.6	0.4	0.7	-0.5	-0.1	0.7	0.8	0.3
Crohns Disease (2017)	1.5	3.3	6.2	-2.5	-1.5	-0.5	-2.4	-1.5	0.5	1.9	2.0	-2.5	1.3	-1.9
Irritable Bowel Disease (IBD)	0.8	1.9	4.0	-1.9	-0.5	0.8	-1.6	-0.4	1.5	1.1	1.3	-2.0	2.0	-0.9
Ulcerative Colitis (UC)	0.4	0.7	2.4	-0.3	0.7	1.6	-0.2	0.7	1.5	-0.3	0.1	-0.6	1.3	0.5
Major Depression (MDD)	2.3	2.8	4.5	-1.9	-1.9	-1.2	-1.6	-2.0	-0.6	2.1	1.9	-1.7	0.3	-2.1
Reaction Time	0.2	0.3	0.9	-0.2	-0.5	0.2	0.0	-0.6	0.3	0.7	0.6	-1.0	0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.9	2.0	1.1	0.1	1.5	1.2	-0.9	-1.8	-1.6	1.6	-1.9	1.6
Breast Cancer	0.2	0.5	1.1	-0.0	0.7	1.0	0.5	0.8	1.0	-0.5	-0.8	0.4	0.8	0.5
Ovarian Cancer	2.6	3.5	7.6	-1.9	-1.9	-1.7	-2.0	-1.8	-0.9	1.8	2.5	-2.8	-0.3	-1.8
Prostate Cancer	1.5	2.0	7.5	-0.4	-1.1	-2.2	-0.5	-1.2	-2.5	-0.1	-0.0	-0.8	-2.7	-0.4
Age at First Birth	2.8	4.0	6.6	-1.7	-2.1	-2.6	-2.3	-2.2	-2.2	1.5	1.9	-2.0	-1.6	-1.8
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.3	0.1	-0.1	0.0	0.1	0.0	-0.2	0.0	-0.6	-0.0	0.2
Body Mass Index (BMI) (2010)	5.7	7.8	13.1	-3.4	-2.8	-1.9	-3.6	-2.8	-0.8	3.2	3.0	-3.4	0.6	-3.2
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.2	-0.3	-0.0	0.2	0.1	-0.3	-0.1	-0.2
Crohns Disease (2012)	0.2	0.3	0.8	-0.5	-0.0	0.4	-0.6	0.1	0.7	0.2	0.8	-0.9	0.8	-0.2
Mean Putamen Volume	0.1	0.1	0.4	0.1	0.2	-0.4	-0.2	0.3	-0.6	-0.4	-0.4	-0.2	-0.7	0.2
Fasting Glucose	0.3	0.3	0.8	-0.9	-0.5	0.0	-0.9	-0.5	0.1	0.6	0.5	-0.8	0.4	-0.5
HbA1C	0.4	0.4	0.6	-0.7	-0.7	-0.8	-0.8	-0.6	-0.5	0.7	0.8	-0.7	-0.4	-0.7
HDL Cholesterol	0.8	1.3	2.3	-1.2	-1.5	-0.9	-0.9	-1.5	-0.5	1.5	1.5	-0.7	0.0	-1.4
LDL Cholesterol	0.7	1.1	2.1	0.4	1.2	1.5	0.9	1.2	0.5	-1.2	-1.4	0.8	0.4	1.2
Lupus	0.2	0.3	0.8	-0.1	-0.6	-0.9	-0.2	-0.6	-0.7	0.3	0.7	-0.3	-0.9	-0.2
Neuroticism (2016)	0.4	0.5	0.8	0.8	0.7	0.1	0.7	0.8	-0.2	-0.9	-0.8	0.8	-0.7	0.9
Primary Biliary Cirrhosis	1.6	2.3	4.8	1.9	1.7	0.8	1.5	1.8	-0.0	-2.2	-1.6	0.7	-1.1	1.9
Rheumatoid Arthritis	0.4	0.5	2.1	0.3	-0.8	-0.8	0.1	-0.9	-1.2	0.2	0.2	-0.0	-1.5	-0.3
Schizophrenia (2014)	0.3	0.6	1.8	-0.9	-0.9	-0.6	-0.6	-0.8	-0.5	0.8	0.8	-1.3	-0.0	-0.8
Triglycerides	3.4	5.5	9.9	2.2	2.7	1.3	2.4	2.7	-0.1	-3.1	-3.1	1.9	-1.3	2.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	0.7	0.7	0.7	0.4	1.1	0.8	-0.4	-0.0	0.5	0.6	0.7
Ulcerative Colitis	0.9	1.2	4.2	-0.4	0.8	2.1	-0.2	0.7	2.0	-0.2	0.1	-0.8	1.8	0.5
Blood Eosinophil Count	0.9	6.8	11.2	3.2	2.7	1.9	2.8	2.7	1.1	-2.8	-2.8	3.4	-0.5	3.1
Blood Platelet Count	6.8	79.2	136.9	-11.4	-8.5	-3.3	-11.2	-8.5	0.5	10.4	9.8	-11.7	5.1	-9.7
Blood Red Count	11.8	114.0	170.5	13.1	11.6	6.8	12.1	11.5	2.7	-13.0	-12.1	11.5	-3.1	12.6
Blood White Count	1.0	7.5	31.0	1.3	-0.5	-3.1	0.8	-0.5	-5.0	-1.7	-2.1	2.3	-5.6	1.2
Heel T-Score	0.1	1.0	3.6	-1.6	-0.4	-0.3	-1.8	-0.4	-0.1	0.5	-0.0	-1.9	0.3	-0.6
BMI	4.5	26.3	36.4	-6.0	-5.8	-4.2	-5.9	-5.8	-2.6	5.7	5.7	-5.4	-0.4	-5.7
Height	12.2	235.0	392.0	19.5	14.9	6.2	17.2	14.9	-0.8	-18.3	-17.3	19.8	-9.4	17.6
Waist Hip Ratio (WHR)	0.6	2.9	6.4	1.1	2.0	1.2	0.9	2.0	-0.0	-2.5	-2.4	1.1	-0.8	2.5
Systolic Blood Pressure	0.5	2.3	6.8	-2.2	-1.1	-1.3	-2.3	-1.1	-1.3	0.7	0.5	-2.6	-0.7	-1.0
Smoking Status	0.2	0.4	1.2	-0.6	-0.5	-0.7	-0.7	-0.5	-0.7	0.3	0.3	-1.1	-0.7	-0.2
Allergy or Eczema	4.1	10.8	18.5	-4.3	-3.2	-2.2	-4.3	-3.2	-0.9	3.5	3.6	-4.0	0.7	-3.6
Cardiovascular Disease	1.9	6.3	12.1	-2.8	-2.3	-2.8	-3.3	-2.3	-2.8	1.5	1.7	-3.5	-2.0	-1.9
Hypothyroidism (self reported)	3.2	7.3	11.3	-3.4	-3.0	-2.7	-3.0	-3.0	-2.2	2.7	2.5	-2.6	-1.0	-3.0
Respiratory disease	0.9	1.9	4.9	-1.9	-1.0	-0.2	-1.7	-1.0	0.2	1.4	1.8	-2.2	0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.3	-0.2	-0.0	0.5	-0.5	0.0	0.9	0.4	0.6	0.0	1.1	-0.2
Lung FEV1/FVC ratio	0.6	3.2	6.8	-1.6	-1.6	-2.5	-1.8	-1.7	-2.6	0.6	0.6	-1.8	-2.3	-1.2
Lung FVC	0.8	4.1	8.4	-1.9	-2.5	-1.4	-1.6	-2.5	-0.3	2.9	2.6	-0.9	1.1	-2.8
Neuroticism	0.7	1.7	3.5	1.7	1.2	0.3	1.9	1.2	-0.4	-1.6	-1.4	0.9	-1.1	1.5
Chronotype (morning person)	2.4	5.5	10.2	2.5	2.8	1.2	2.2	2.7	0.3	-3.1	-3.2	2.1	-0.9	2.8
Hair Pigment	0.0	0.7	2.9	0.0	-0.0	0.7	0.5	-0.1	1.2	0.5	0.1	1.4	1.7	-0.3
Tanning	0.5	6.1	9.2	-2.9	-2.9	-1.8	-2.4	-2.9	-1.0	3.0	2.7	-2.5	0.5	-3.0
Hand grip strength (left)	1.9	5.1	9.7	3.1	1.8	-0.2	2.4	1.8	-1.0	-2.6	-2.4	3.1	-2.3	2.3
Number of treatments/medications taken	2.0	3.7	5.8	-2.4	-2.0	-2.0	-2.2	-2.0	-1.7	1.7	1.6	-2.2	-0.9	-1.8
Average weekly spirits intake	0.9	1.1	2.3	-0.8	-1.2	-0.6	-1.0	-1.2	-0.3	1.2	1.5	-1.4	0.2	-1.2
Sensitivity / hurt feelings	0.3	0.6	1.2	0.8	0.8	0.7	1.1	0.8	0.4	-0.9	-0.9	0.2	0.2	0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.0	-0.1	-0.5	-0.1	-0.2	-0.6	-0.1	-0.0	-0.2	-0.6	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	1.0	0.3	-0.7	-0.2	0.1	-0.7	0.0	0.8	1.0	0.0	0.4	-0.8
Relative age of first facial hair	1.6	3.4	6.1	-2.5	-1.7	-0.7	-2.2	-1.8	0.0	2.2	1.9	-2.2	1.2	-2.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.0	-0.6	-1.0	-1.4	-0.9	-1.0	-1.7	0.3	0.5	-0.7	-1.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	0.6	0.8	1.4	0.9	0.8	1.4	-0.4	-0.3	1.2	1.3	0.5
Ever had hysterectomy (womb removed)	1.7	1.9	3.4	1.4	1.5	1.4	1.8	1.6	0.9	-1.5	-1.6	1.2	0.4	1.3
Systolic blood pressure, automated reading	2.1	6.0	12.6	-3.5	-2.3	-1.2	-3.3	-2.3	-0.4	2.5	2.6	-3.2	0.8	-2.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	3.9	-1.5	-0.9	0.6	-1.1	-0.9	1.2	1.6	1.9	-0.8	2.0	-1.1
Angina	0.3	0.5	1.7	-0.6	-0.4	-0.9	-0.2	-0.4	-1.3	-0.2	-0.3	-0.3	-1.2	0.0
Medication for hormone replacement therapy	0.7	0.7	1.6	-1.3	-0.9	-0.9	-1.1	-0.8	-0.7	0.8	0.6	-0.8	-0.1	-0.9
Vitamin and mineral supplements	0.1	0.1	0.6	0.3	0.1	-0.4	-0.1	0.1	-0.6	-0.3	-0.2	0.0	-0.8	0.2
Supplements: Zinc	2.4	2.6	4.7	1.5	1.8	2.2	1.6	1.8	1.9	-1.4	-1.3	1.1	1.2	1.5
Medication: Co-codamol	1.6	1.9	4.0	-1.6	-1.3	-0.4	-1.4	-1.3	0.3	1.7	2.0	-1.1	1.4	-1.6
Medication: Metformin	0.5	0.7	3.4	-0.1	0.2	1.2	-0.1	0.2	1.6	0.5	0.5	-0.1	1.8	-0.1
Diabetes (father)	0.7	0.9	3.5	-0.7	0.0	1.0	-0.5	-0.0	1.6	0.7	1.0	-0.4	1.9	-0.4
Diabetes (mother)	0.3	0.4	0.8	-0.6	-0.8	-0.3	-0.3	-0.9	-0.3	0.8	0.6	-0.8	0.3	-0.9
Severe depression (siblings)	0.0	0.1	0.2	0.2	0.1	0.3	0.1	0.1	0.3	-0.0	0.2	-0.0	0.5	0.1
Pack years adult smoking proportion	0.2	0.4	0.7	0.6	0.6	0.8	0.6	0.5	0.8	-0.3	-0.1	0.6	0.8	0.4
Impedance of leg (right)	7.5	36.5	50.6	6.7	7.0	5.1	6.7	6.9	3.1	-7.1	-6.5	6.2	0.1	7.1
Leg fat-free mass (left)	0.4	2.3	11.0	0.9	-0.2	-1.8	0.4	-0.2	-2.6	-0.9	-0.8	1.1	-3.3	0.5
Trunk fat percentage	0.1	0.6	1.3	-1.1	-0.6	-0.1	-1.1	-0.6	0.2	0.8	1.1	-0.4	0.4	-0.8
Hand grip strength (right)	2.6	7.1	14.7	3.6	2.5	0.9	3.0	2.5	-0.1	-3.1	-2.7	3.8	-1.5	3.0
Townsend deprivation index at recruitment	3.2	4.5	7.0	-2.6	-2.3	-1.0	-2.6	-2.4	-0.5	2.5	2.4	-2.3	0.7	-2.3
Current tobacco smoking	0.4	0.6	1.2	-1.0	-0.7	-0.6	-1.1	-0.8	-0.5	0.6	0.8	-1.0	-0.1	-0.7
Average weekly fortified wine intake	0.4	0.4	1.6	-0.0	0.0	0.7	0.3	-0.1	1.1	0.5	0.7	0.8	1.3	-0.3
Maternal smoking around birth	0.9	1.3	3.7	-0.4	-0.9	-1.7	-0.7	-0.9	-1.9	0.2	0.3	-1.3	-1.8	-0.4
Fed-up feelings	0.1	0.2	0.5	-0.5	-0.2	0.3	0.2	-0.2	0.4	0.3	0.4	-0.7	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.5	3.9	-1.5	-1.8	-1.3	-1.7	-1.8	-0.7	1.8	2.0	-1.6	0.2	-1.9
Relative age voice broke	0.9	1.4	3.8	-1.6	-0.8	-0.1	-1.7	-0.8	0.5	1.2	1.3	-2.0	1.0	-1.1
Taking other prescription medications	4.1	6.3	9.3	-3.0	-2.7	-2.2	-3.0	-2.7	-1.5	2.6	2.5	-3.0	-0.4	-2.7
Age when periods started (menarche)	0.0	0.1	0.3	-0.5	0.0	-0.3	-0.5	0.0	-0.2	-0.1	0.4	0.2	-0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	-0.6	-0.7	-0.8	-0.3	-0.7	-0.8	0.5	0.2	-0.4	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.1	0.3	0.6	0.0	0.3	0.3	-0.4	-0.4	0.6	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.0	-1.6	-1.3	-1.0	-1.2	-1.2	-0.5	1.3	1.3	-1.7	0.1	-1.3
Qualifications: CSEs or equivalent	0.4	0.5	2.4	0.2	0.5	1.0	0.5	0.4	1.3	-0.0	0.1	-0.1	1.6	0.1
Serious illness, injury or assault to yourself	1.3	1.6	3.4	-1.9	-1.5	-1.1	-1.5	-1.4	-0.9	1.4	0.8	-1.3	-0.2	-1.3
High blood pressure	4.1	11.3	15.1	-3.6	-3.6	-3.9	-3.9	-3.5	-3.6	2.7	2.7	-3.7	-2.3	-3.1
Hayfever, allergic rhinitis or eczema	1.9	4.1	8.3	-2.7	-1.8	-1.2	-2.9	-1.8	-0.4	2.0	2.2	-2.9	0.5	-2.1
Multivitamins +/- minerals	1.3	1.7	4.1	0.7	1.1	2.0	1.4	1.1	2.0	-0.4	-0.8	1.0	2.0	0.6
Stomach or abdominal pain in last month	0.6	0.7	2.0	-1.4	-0.5	-0.0	-1.0	-0.4	0.4	0.8	0.7	-1.0	1.0	-0.9
Supplements: Glucosamine	0.0	0.0	0.1	-0.3	0.0	-0.1	0.0	0.0	-0.3	-0.1	-0.3	0.2	-0.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.6	-0.5	-0.2	0.5	-0.3	-0.2	0.8	0.6	0.8	-0.3	1.2	-0.5
Medication: Atenolol	0.7	0.8	3.6	0.2	-0.2	-1.1	0.3	-0.2	-1.7	-0.6	-0.9	0.0	-1.9	0.2
Medication: Levothyroxine sodium	1.8	3.0	4.1	-1.9	-2.0	-2.0	-1.8	-1.9	-1.9	1.6	1.4	-1.1	-1.2	-1.8
Sitting height	6.0	42.9	70.7	8.2	6.2	2.6	7.5	6.1	-0.9	-7.9	-7.7	8.4	-4.3	7.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.6	-0.5	-0.2	-0.2	-0.5	-0.3	0.5	0.2	-0.4	-0.0	-0.7
High blood pressure (mother)	0.8	1.1	2.8	-1.3	-1.0	-1.0	-1.1	-1.0	-0.6	1.0	0.7	-1.7	-0.1	-1.1
Body mass index (BMI)	4.5	19.1	27.2	-5.2	-4.8	-3.0	-5.0	-4.8	-1.5	5.1	5.1	-4.8	0.6	-5.1
Impedance of leg (left)	8.2	40.0	55.1	7.2	7.2	5.2	7.0	7.2	3.1	-7.3	-6.9	6.6	0.1	7.4
Leg predicted mass (left)	0.4	2.3	11.4	0.9	-0.2	-1.8	0.4	-0.2	-2.7	-0.9	-0.9	1.1	-3.4	0.5
Trunk fat mass	0.1	0.2	1.1	-0.1	-0.2	-0.5	-0.3	-0.2	-0.8	-0.1	0.1	0.6	-1.1	-0.0
Waist circumference	0.4	1.4	2.3	-1.5	-1.3	-1.1	-1.5	-1.3	-1.2	1.0	1.1	-0.8	-0.8	-1.1
Number of incorrect matches in round	0.6	0.9	2.9	0.8	0.7	1.5	0.9	0.8	1.7	-0.2	-0.3	0.4	1.5	0.5
Past tobacco smoking	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.3	-0.2	-0.3	0.0	0.0	0.5	-0.0	-0.2
Alcohol usually taken with meals	4.0	6.5	11.8	3.2	2.5	1.7	3.2	2.6	0.7	-2.7	-2.7	3.4	-0.4	3.0
Nervous feelings	0.1	0.1	0.4	0.5	0.1	0.3	0.6	0.0	0.4	-0.0	0.4	0.2	0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.7	0.5	0.0	0.4	0.5	-0.4	-0.8	-0.3	-0.4	-0.7	0.6
Hearing difficulty/problems with background noise	1.0	1.5	3.8	1.9	1.1	1.0	1.8	1.1	0.2	-1.4	-1.1	1.4	-0.4	1.3
Hair/balding pattern: Pattern 2	0.6	0.8	3.0	-0.0	0.7	1.5	0.2	0.7	1.7	-0.0	-0.1	0.4	1.6	0.3
Had menopause	0.9	1.1	4.2	-0.3	0.1	1.2	0.2	0.1	1.9	0.7	0.8	0.9	2.0	-0.4
Had other major operations	0.1	0.1	0.2	-0.0	-0.3	-0.3	0.1	-0.3	-0.2	0.2	0.1	0.5	0.1	-0.3
Forced vital capacity (FVC)	3.1	12.1	22.6	4.8	2.7	0.1	3.9	2.7	-1.6	-4.0	-4.0	4.6	-3.4	3.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	-0.2	-0.0	-0.5	-0.5	-0.0	-0.8	-0.4	-0.7	0.2	-0.8	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.9	0.2	-0.3	-0.8	0.1	-0.3	-0.8	-0.1	-0.2	0.1	-1.0	-0.1
Qualifications: None of the above	6.5	13.9	19.4	-4.3	-4.2	-3.1	-4.3	-4.2	-1.4	4.4	4.2	-3.7	0.3	-4.3
Financial difficulties in last 2 years	0.4	0.5	0.8	0.8	0.8	0.8	0.8	0.8	0.4	-0.8	-0.9	0.3	-0.1	0.8
Mouth/teeth dental problems	10.4	16.0	23.6	4.7	4.5	3.1	4.9	4.4	1.6	-4.6	-4.2	4.4	-0.5	4.5
Heart attack	0.9	1.1	4.8	0.1	0.3	-0.7	-0.2	0.3	-1.6	-1.2	-1.4	-0.3	-2.2	0.9
Allergy	1.9	4.4	8.5	2.8	1.8	0.7	2.9	1.7	-0.1	-2.3	-2.6	2.9	-1.2	2.1
Pain all over the body in last month	0.5	0.6	0.9	-0.6	-0.8	-0.9	-1.0	-0.8	-0.9	0.5	0.5	-0.7	-0.9	-0.5
Diabetes (self-reported)	0.9	1.3	6.1	-0.6	-0.0	1.2	-0.5	-0.1	2.0	1.0	1.1	-0.3	2.5	-0.5
Hayfever/allergic rhinitis (self-reported)	2.5	3.4	6.2	-2.5	-1.6	-0.9	-2.4	-1.7	0.0	1.9	2.0	-2.3	0.9	-2.1
Medication: Ramipril	1.0	1.3	3.4	-1.8	-1.2	-0.3	-1.4	-1.2	-0.0	1.3	1.4	-0.9	0.6	-1.1
Medication: Simvastatin	0.3	0.4	1.9	-0.9	-0.4	-0.2	-1.0	-0.4	-0.5	0.2	0.6	-1.4	-0.4	-0.2
Fluid intelligence score	0.6	1.3	2.5	1.6	0.8	-0.1	1.3	0.9	-0.7	-1.3	-1.1	1.0	-1.5	1.2
Illnesses of siblings	0.6	0.8	1.8	-0.6	-0.9	-0.3	-0.7	-0.9	0.4	1.3	1.3	-1.0	0.9	-1.0
Neuroticism score	0.7	1.5	3.6	1.6	1.3	0.9	1.9	1.3	0.4	-1.4	-1.3	0.8	-0.1	1.3
Weight	0.2	1.2	5.8	0.7	-0.2	-1.2	0.2	-0.2	-1.9	-0.6	-0.5	1.1	-2.4	0.4
Impedance of arm (right)	2.9	13.7	19.3	3.5	4.4	3.7	3.7	4.3	2.9	-3.9	-3.6	4.1	1.2	4.1
Arm fat percentage (right)	2.2	8.6	15.5	-3.9	-3.0	-1.5	-3.5	-3.0	-0.3	3.5	3.5	-3.0	1.1	-3.4
Trunk fat-free mass	2.3	13.1	32.7	4.1	1.9	-1.4	3.2	1.9	-3.7	-4.0	-4.1	4.2	-5.7	3.3
Hip circumference	0.2	0.9	3.1	-0.3	-0.8	-1.4	-0.5	-0.8	-1.7	0.3	0.4	0.2	-1.8	-0.5
Time employed in main current job	2.2	2.6	3.9	-1.3	-2.0	-1.9	-1.4	-2.0	-1.7	1.5	2.0	-0.2	-1.1	-1.7
Alcohol intake versus 10 years previously	0.7	1.1	2.8	-1.2	-1.0	-0.7	-1.4	-1.0	-0.2	1.1	0.8	-1.7	0.3	-0.9
Father’s age at death	1.3	1.8	3.6	-1.6	-1.3	-0.0	-1.2	-1.3	0.6	1.9	1.7	-0.1	1.5	-1.7
Worrier / anxious feelings	0.3	0.5	1.0	0.7	0.6	-0.1	0.9	0.6	-0.4	-0.9	-1.0	0.3	-1.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	-0.1	-0.2	-0.6	-0.1	-0.2	-0.6	-0.1	-0.1	-0.5	-0.8	-0.0
Falls in the last year	0.2	0.3	1.0	-0.5	-0.1	0.7	-0.1	-0.1	0.6	0.4	0.4	-0.7	1.0	-0.2
Hair/balding pattern: Pattern 3	0.8	1.2	4.3	2.1	1.1	0.5	1.7	1.0	0.3	-1.1	-0.3	0.6	-0.2	1.2
Number of live births	0.1	0.1	0.7	-0.0	0.1	0.4	-0.1	0.2	0.6	0.2	0.3	-0.3	0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	2.1	6.9	12.5	3.5	1.7	-0.6	2.8	1.7	-1.9	-3.0	-2.9	3.3	-3.3	2.7
Pulse rate	0.4	0.7	1.3	0.8	0.7	1.1	0.9	0.7	1.1	-0.4	-0.3	1.1	0.9	0.7
Happiness	0.1	0.2	0.7	0.6	-0.1	-0.4	0.5	-0.0	-0.4	-0.0	0.1	0.8	-0.5	0.1
Noisy workplace	2.1	2.5	5.4	-2.3	-1.6	-1.2	-2.0	-1.6	-0.6	1.7	1.4	-2.0	0.2	-1.7
Qualifications: A levels/AS levels or equivalent	7.6	16.8	25.1	4.8	4.4	2.5	4.6	4.3	0.5	-5.0	-4.9	4.4	-1.8	5.0
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.4	-1.5	-1.2	0.1	-1.3	-1.2	1.0	1.9	2.1	-1.4	1.8	-1.6
Mouth/teeth dental problems: Dentures	7.3	12.2	19.2	-4.1	-4.0	-3.5	-4.4	-3.9	-2.6	3.6	3.0	-3.4	-1.0	-3.7
Asthma	0.4	0.7	2.5	-1.0	-0.3	0.4	-1.0	-0.3	0.7	0.7	1.1	-1.6	1.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.1	1.8	1.6	1.3	1.7	1.6	1.2	-1.4	-1.5	1.1	0.6	1.4
Medication: Cholesterol lowering	0.2	0.4	0.9	0.0	0.8	0.6	-0.1	0.8	0.1	-0.9	-0.7	-0.2	-0.2	0.9
Depression (self-reported)	0.9	1.1	2.1	1.2	1.0	1.4	1.2	0.9	1.4	-0.7	-0.3	0.5	1.2	0.7
Medication: Lansoprazole	0.6	0.7	3.2	-0.2	0.1	-1.0	-0.1	0.1	-1.4	-0.7	-0.8	-0.2	-1.8	0.4
Prospective memory result	0.4	0.4	1.8	0.1	0.4	1.0	0.4	0.3	1.2	0.0	0.3	0.3	1.4	0.2
Lung cancer (father)	0.7	0.8	1.2	-0.9	-1.1	-1.0	-0.9	-1.0	-0.7	1.0	1.1	-0.7	-0.4	-0.9
Illnesses of mother	2.2	2.7	5.6	1.8	1.7	1.9	1.6	1.7	1.5	-1.4	-1.2	2.4	0.8	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	10.3	2.9	1.6	-0.5	2.6	1.5	-1.9	-2.9	-2.9	3.0	-3.2	2.5
Pulse wave Arterial Stiffness index	4.8	5.6	9.5	2.5	2.7	2.4	3.1	2.7	1.9	-2.5	-2.2	1.8	0.9	2.5
Impedance of arm (left)	2.7	12.4	17.3	3.4	4.2	3.8	3.5	4.1	3.1	-3.5	-3.2	3.9	1.6	3.9
Arm fat mass (right)	1.2	5.1	7.1	-2.7	-2.5	-1.9	-2.7	-2.5	-1.4	2.4	2.5	-2.2	-0.5	-2.5
Trunk predicted mass	2.3	13.3	33.4	4.1	1.9	-1.4	3.2	1.9	-3.7	-4.0	-4.1	4.2	-5.8	3.4
Standing height	9.9	98.5	158.8	12.4	9.5	3.6	10.9	9.4	-1.3	-12.0	-11.6	12.6	-6.9	11.5
Length of working week for main job	1.1	1.2	2.4	-1.2	-1.1	-1.6	-1.3	-1.1	-1.3	0.8	0.5	-1.1	-1.0	-1.0
Exposure to tobacco smoke at home	0.9	1.1	2.0	-1.1	-1.2	-0.3	-1.0	-1.2	0.0	1.4	1.4	-1.0	0.7	-1.2
Breastfed as a baby	1.4	1.8	2.9	1.6	1.1	0.1	1.3	1.2	-0.7	-1.6	-1.7	1.6	-1.5	1.5
Tense / ‘highly strung’	0.4	0.7	1.6	1.2	0.7	0.0	1.2	0.7	-0.3	-1.0	-0.7	0.5	-0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.2	0.4	0.2	0.1	0.5	0.2	0.0	-0.3	-0.1	-0.0	0.1	0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.6	0.4	0.0	0.1	0.1	0.0	-0.2	-0.2	0.8	-0.3	-0.3	0.2
Birth weight of first child	0.2	0.3	1.0	0.1	-0.6	-1.0	-0.3	-0.4	-0.6	0.4	0.5	0.1	-0.7	-0.6
Peak expiratory flow (PEF)	1.0	2.3	9.8	1.2	0.0	-1.6	0.4	-0.0	-2.5	-1.1	-1.2	1.3	-3.1	0.9
Pulse wave reflection index	6.9	8.5	15.7	3.6	3.2	2.1	4.0	3.1	1.1	-3.3	-3.4	2.5	-0.2	3.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.7	-0.1	-0.7	-0.6	-0.1	-0.5	-0.0	0.1	-0.8	-0.6	-0.1
Loud music exposure frequency	0.1	0.1	0.3	0.0	0.4	0.0	0.2	0.3	-0.2	-0.5	-0.5	0.0	-0.3	0.2
Qualifications: O levels/GCSEs or equivalent	5.8	9.2	16.2	3.2	3.1	1.1	3.1	3.1	-0.6	-4.0	-3.9	3.0	-2.5	3.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.5	-0.7	0.3	-0.7	-0.7	0.8	1.2	1.1	-1.0	1.4	-1.0
Blood clot in the leg (DVT)	1.3	1.7	3.2	-1.4	-1.3	-1.8	-1.2	-1.3	-1.8	0.7	0.8	-1.2	-1.4	-1.0
Medication: Paracetamol	0.4	0.7	1.6	1.2	0.4	-0.6	1.3	0.4	-0.8	-0.9	-0.5	0.5	-1.1	0.6
Headache pain in last month	0.0	0.1	0.2	0.3	0.2	0.1	0.5	0.3	0.3	-0.2	-0.1	0.0	0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.3	1.6	1.1	1.3	1.8	1.0	1.5	-0.7	-0.6	1.5	1.1	0.8
Glaucoma (self-reported)	0.2	0.2	0.7	0.1	-0.2	-0.5	-0.4	-0.3	-0.8	-0.1	0.2	-0.4	-0.9	0.1
Gout (self-reported)	1.4	1.9	3.3	-1.8	-1.3	-1.6	-1.8	-1.2	-1.5	0.9	0.9	-1.7	-1.1	-1.0
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	10.3	-3.2	-3.0	-2.6	-2.8	-3.0	-1.8	2.9	2.6	-2.2	-0.6	-3.0
Medication: Amlodipine	4.6	6.5	8.6	-2.9	-2.9	-2.4	-2.8	-2.9	-1.8	2.6	2.6	-2.9	-0.6	-2.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	-0.6	-0.4	0.2	-0.7	-0.4	0.5	0.7	0.5	-1.4	0.8	-0.7
Birth weight	0.1	0.3	1.2	0.5	-0.2	-0.4	0.5	-0.1	-0.6	-0.1	-0.1	1.1	-0.7	0.1
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.9	-1.8	-1.4	-1.4	-1.8	-1.5	-1.1	1.3	1.2	-2.2	-0.4	-1.4
High blood pressure (siblings)	0.4	0.6	1.6	0.5	0.6	-0.0	0.4	0.6	-0.7	-1.1	-1.1	0.7	-1.3	0.9
Forced vital capacity (FVC), Best measure	2.6	9.5	17.1	4.0	2.4	-0.0	3.4	2.3	-1.6	-3.6	-3.6	4.1	-3.2	3.3
Body fat percentage	0.4	1.6	3.3	-1.8	-1.1	-0.3	-1.6	-1.1	0.2	1.5	1.7	-1.2	0.8	-1.4
Leg fat percentage (right)	0.7	2.4	4.8	-2.2	-1.4	-0.3	-1.8	-1.4	0.3	1.8	2.0	-1.9	1.0	-1.7
Arm fat-free mass (right)	1.3	6.8	16.6	3.2	1.4	-0.9	2.4	1.4	-2.5	-2.8	-2.8	3.0	-4.1	2.4
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-0.8	-0.8	-1.0	-0.6	-0.7	-0.8	0.7	0.3	-1.1	-0.4	-0.8
Comparative body size at age 10	5.2	14.5	19.5	-4.1	-4.4	-3.9	-4.1	-4.4	-3.0	4.0	3.8	-3.6	-1.3	-4.1
Number of full brothers	0.3	0.4	0.9	-0.7	-0.5	-0.9	-0.5	-0.5	-1.0	0.1	-0.1	-0.8	-0.8	-0.5
Worry too long after embarrassment	9.8	16.5	21.9	4.3	4.7	4.5	4.7	4.6	3.6	-3.9	-3.8	3.5	2.1	4.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.9	-0.9	-1.2	-1.4	-1.0	-1.3	-1.2	0.9	1.2	-0.7	-0.8	-1.1
Wheeze or whistling in the chest in last year	2.7	4.8	8.4	-2.7	-2.2	-1.2	-2.8	-2.1	-0.1	2.5	2.3	-2.9	0.8	-2.5
Number of children fathered	0.7	0.8	1.7	-0.9	-0.9	-1.3	-1.0	-0.9	-1.1	0.6	0.5	-0.5	-1.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	6.0	2.1	2.0	2.2	1.9	2.0	1.6	-1.6	-1.6	2.4	0.9	1.8
Age at first live birth	2.3	4.1	5.4	2.2	2.3	2.3	2.1	2.3	1.9	-2.0	-1.3	2.2	0.9	2.2
Pulse wave peak to peak time	2.5	3.0	5.2	-1.6	-2.0	-2.0	-2.3	-1.9	-1.9	1.6	1.4	-1.0	-1.3	-1.6
Health satisfaction	0.4	0.5	1.3	0.4	0.6	0.9	0.5	0.6	1.2	-0.3	-0.0	0.7	1.0	0.4
Shortness of breath walking on level ground	0.0	0.1	0.3	-0.5	-0.3	0.0	-0.1	-0.4	-0.1	0.2	0.2	-0.0	-0.0	-0.1
Qualifications: College or University degree	2.2	7.1	10.7	3.3	2.8	1.7	3.2	2.6	0.6	-3.2	-2.9	2.9	-1.0	3.2
Eye problems/disorders: None of the above	0.9	1.0	2.5	1.6	1.1	0.8	1.3	1.1	0.5	-1.0	-0.9	1.1	0.3	0.9
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.2	2.0	1.9	1.3	1.5	1.9	0.7	-1.9	-1.9	1.3	-0.3	2.1
Emphysema/chronic bronchitis	1.2	1.3	5.4	0.2	0.6	2.0	0.5	0.6	2.0	0.2	0.3	0.4	2.3	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	-0.5	-0.2	0.4	-0.5	-0.2	0.6	0.5	0.4	0.2	0.8	-0.3
Neck or shoulder pain in last month	1.4	2.0	2.9	-1.6	-1.7	-1.0	-1.5	-1.7	-0.8	1.6	1.6	-1.6	-0.1	-1.6
Medication: Blood pressure	4.4	7.7	11.4	-2.9	-3.0	-3.4	-3.1	-2.9	-3.3	2.1	2.1	-2.6	-2.3	-2.5
Angina (self-reported)	0.2	0.3	1.2	-0.6	-0.3	-0.7	-0.2	-0.3	-1.1	-0.2	-0.4	-0.3	-1.0	0.1
Migraine (self-reported)	0.4	0.6	1.2	0.8	0.7	-0.0	0.4	0.8	-0.4	-1.0	-1.1	-0.0	-1.0	0.8
Medication: Ibuprofen	0.6	0.8	1.3	0.9	1.1	0.9	0.8	1.1	1.1	-0.8	-0.7	0.3	0.8	0.8
Medication: Allopurinol	0.4	0.5	1.1	-1.0	-0.7	-0.5	-1.0	-0.6	-0.1	0.8	0.8	-0.8	0.3	-0.7
Medication: Omeprazole	2.6	3.2	4.9	2.0	2.1	1.7	1.9	2.0	1.0	-2.2	-2.1	1.3	0.2	2.0
Medication: Seretide 50 evohaler	1.3	1.5	2.6	-1.3	-1.2	-0.2	-1.5	-1.2	0.4	1.6	1.6	-1.5	1.0	-1.3
Mean time to correctly identify matches	0.2	0.4	0.7	-0.6	-0.6	0.3	-0.2	-0.7	0.4	0.8	0.7	-0.6	0.8	-0.7
Heart disease (mother)	4.5	5.5	14.7	-1.5	-2.2	-3.4	-1.9	-2.2	-3.8	0.9	0.9	-1.7	-3.5	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.3	-1.6	-1.0	-0.8	-1.8	-0.9	-0.0	1.2	1.6	-2.1	0.3	-1.2
Whole body fat mass	0.2	0.8	1.2	-1.1	-1.0	-0.9	-1.1	-1.0	-0.9	0.8	1.0	-0.5	-0.7	-0.9
Leg fat mass (right)	0.4	1.6	2.5	-1.6	-1.4	-1.1	-1.5	-1.4	-0.9	1.2	1.3	-1.2	-0.6	-1.3
Arm predicted mass (right)	1.3	6.9	18.7	3.1	1.3	-1.1	2.3	1.3	-2.8	-2.8	-2.8	2.9	-4.3	2.4
Pulse rate, automated reading	1.8	5.8	7.8	2.8	2.7	2.7	2.6	2.7	2.0	-2.4	-2.1	2.3	0.9	2.6
Alcohol intake frequency.	1.6	3.8	5.9	-1.9	-2.0	-2.4	-2.1	-2.1	-2.1	1.5	1.3	-2.4	-1.2	-2.0
Comparative height size at age 10	9.0	49.7	81.0	8.8	6.5	2.1	7.9	6.5	-1.4	-8.4	-8.5	9.0	-5.3	7.9
Number of full sisters	1.5	1.8	3.3	-1.5	-1.5	-0.8	-1.6	-1.4	-0.4	1.6	1.8	-1.1	0.3	-1.6
Suffer from ‘nerves’	0.2	0.3	0.8	0.0	-0.5	-0.6	0.1	-0.5	-0.5	0.3	0.8	-0.9	-0.6	-0.4
Overall health rating	1.7	3.6	7.1	-2.7	-2.0	-1.4	-2.2	-2.0	-0.7	2.0	1.8	-2.3	0.2	-2.1
Chest pain or discomfort	0.3	0.4	1.8	-0.1	-0.2	-0.7	-0.5	-0.1	-1.2	-0.3	-0.3	-0.5	-1.3	0.1
Had major operations	0.4	0.5	2.3	-0.0	-0.2	-1.0	-0.0	-0.2	-1.3	-0.3	-0.4	-0.1	-1.5	0.1
Age at last live birth	2.5	3.6	7.5	1.7	1.8	2.7	1.7	1.9	2.7	-1.0	-0.5	1.9	2.3	1.5
Family relationship satisfaction	0.7	0.9	2.9	0.9	0.8	0.8	1.2	0.8	0.4	-0.9	-0.9	1.7	0.2	1.0
Leg pain on walking	0.3	0.3	0.8	-0.7	-0.6	0.0	-0.6	-0.6	0.1	0.8	0.9	-0.3	0.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.8	0.3	0.7	-0.0	0.0	0.7	-1.0	-1.2	-1.3	-0.7	-1.3	0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.4	-0.7	-0.9	-1.5	-0.8	-0.7	-1.4	0.4	0.4	-1.4	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	1.4	1.3	0.8	1.2	1.3	0.2	-1.5	-1.4	1.8	-0.5	1.5
Medication: Aspirin	0.8	1.1	1.8	-1.0	-1.0	-1.1	-1.1	-1.1	-1.3	0.6	0.9	-1.3	-1.0	-0.7
Supplements: Vitamin C	0.5	0.6	2.2	-0.4	-0.5	-1.2	-0.5	-0.6	-1.3	0.1	0.2	0.3	-1.5	-0.1
Knee pain experienced in last month	0.8	1.2	1.8	-1.3	-1.1	-1.3	-1.3	-1.1	-1.3	0.8	0.6	-1.2	-0.9	-1.0
Hypertension (Self-reported)	4.3	11.9	16.4	-3.9	-3.8	-3.5	-4.0	-3.7	-3.1	3.2	3.3	-3.6	-1.5	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	-0.1	0.7	0.6	-0.1	0.6	0.9	-0.4	-0.1	-0.4	0.7	0.2
Illnesses of father: Heart disease	1.4	1.9	3.0	1.6	1.7	1.0	1.2	1.7	0.8	-1.7	-1.7	1.2	0.3	1.5
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.8	-0.5	-0.4	-0.5	-0.5	-0.6	0.1	-0.2	-0.7	-0.5	-0.4
Smoking status: Previous	0.2	0.3	1.2	-0.4	-0.5	-0.2	-0.2	-0.4	0.1	0.6	0.7	-1.1	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	4.9	10.2	17.5	3.9	3.1	0.7	3.0	3.1	-0.9	-4.2	-3.9	3.5	-2.7	3.8
Whole body fat-free mass	1.3	7.5	23.6	3.0	1.1	-1.5	2.1	1.1	-3.3	-2.8	-2.9	3.0	-4.9	2.3
Leg fat-free mass (right)	0.5	2.6	11.9	1.2	-0.2	-1.9	0.5	-0.2	-2.7	-0.9	-1.0	1.3	-3.5	0.6
Arm fat percentage (left)	2.5	9.8	16.6	-4.1	-3.2	-1.6	-3.8	-3.2	-0.3	3.8	3.8	-3.3	1.2	-3.6
Average weekly red wine intake	0.8	1.2	5.5	0.9	-0.0	-0.9	0.7	-0.1	-1.8	-0.8	-0.6	1.0	-2.3	0.8
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.8	1.2	1.4	0.3	1.2	1.4	-1.0	-2.2	-2.4	0.9	-2.1	2.1
Mood swings	0.0	0.1	0.7	-0.1	-0.1	-0.2	0.1	-0.0	0.0	0.0	-0.1	-0.8	-0.2	-0.1
Loneliness, isolation	0.9	1.2	2.4	-1.0	-1.2	-0.8	-0.9	-1.2	-0.3	1.4	1.5	-1.3	0.5	-1.6
Long-standing illness, disability or infirmity	3.1	4.7	7.7	-2.7	-2.3	-1.1	-2.5	-2.3	-0.3	2.5	2.4	-2.8	0.9	-2.4
Ever had bowel cancer screening	0.4	0.4	0.7	-0.8	-0.6	-0.3	-0.9	-0.7	0.0	0.7	0.8	-0.8	0.1	-0.7
Diabetes diagnosed by doctor	0.5	0.8	3.6	-0.6	-0.1	0.9	-0.7	-0.1	1.5	0.8	0.9	-0.4	1.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	3.9	1.6	1.9	2.0	1.6	1.9	1.4	-1.6	-1.6	1.6	0.9	1.7
Friendships satisfaction	0.4	0.5	1.8	1.0	0.5	0.6	0.8	0.6	0.7	-0.3	-0.2	1.3	0.6	0.5
Qualifications: nursing, teaching	0.9	1.5	2.3	1.5	1.3	1.2	1.5	1.3	0.8	-1.1	-1.0	1.5	0.2	1.3
Commuting to job workplace: Walk	1.6	1.7	3.3	0.9	1.3	1.8	1.3	1.2	1.6	-0.9	-0.8	1.7	1.4	1.1
Eye problems/disorders: Cataract	1.1	1.3	2.5	-1.4	-1.2	-1.6	-1.2	-1.2	-1.3	0.8	0.7	-0.9	-1.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.0	-1.1	-0.8	0.4	-0.9	-0.8	1.0	1.3	1.3	-0.8	1.7	-1.2
Medication for cholesterol	3.8	5.7	8.3	2.9	2.6	2.2	2.9	2.7	1.6	-2.4	-2.3	2.8	0.4	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.2	7.3	9.9	-2.9	-3.1	-2.4	-2.9	-3.0	-1.8	3.0	3.1	-2.6	-0.1	-3.1
Back pain experienced in last month	0.3	0.4	1.2	-1.1	-0.4	-0.1	-0.6	-0.4	0.3	0.6	0.5	-0.9	0.6	-0.6
Mineral and other dietary supplements	0.4	0.6	1.3	-0.6	-0.7	-0.9	-1.1	-0.6	-0.7	0.6	0.7	-1.2	-0.5	-0.5
Breast cancer (self-reported)	0.6	0.8	1.7	1.2	0.7	0.4	1.3	0.5	-0.1	-0.9	-0.9	1.3	-0.5	0.9
Asthma (self-reported)	0.4	0.7	2.2	-1.0	-0.3	0.4	-0.9	-0.3	0.7	0.8	1.0	-1.5	1.0	-0.6
Osteoporosis (self-reported)	1.6	1.9	3.3	-1.4	-1.6	-1.4	-1.4	-1.6	-1.0	1.5	1.8	-0.9	-0.4	-1.6
Osteoarthritis (self-reported)	1.9	2.4	3.9	-1.7	-1.8	-1.3	-1.6	-1.8	-0.6	1.9	1.7	-1.6	0.4	-2.0
Medication: Aspirin	0.4	0.6	1.6	-0.6	-0.7	-0.9	-0.7	-0.7	-1.2	0.3	0.6	-0.8	-1.0	-0.4
Medication: Gliclazide	0.4	0.4	0.9	0.7	0.5	0.8	0.7	0.5	0.9	-0.3	0.0	0.9	0.6	0.6
Illnesses of father: None of the above (group 1)	1.4	1.8	3.3	1.8	1.2	0.9	1.8	1.3	0.3	-1.3	-1.2	1.8	-0.4	1.5
Smoking status: Current	0.2	0.3	1.0	-0.8	-0.4	-0.3	-1.0	-0.5	-0.3	0.4	0.5	-1.0	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.0	0.1	-0.4	0.5	0.0	-0.5	-0.4	-0.8	0.6	-0.7	0.2
Whole body water mass	1.2	6.9	23.1	2.8	0.9	-1.7	1.9	0.9	-3.4	-2.6	-2.7	2.8	-4.8	2.1
Leg predicted mass (right)	0.5	2.6	12.1	1.1	-0.3	-1.9	0.4	-0.3	-2.8	-0.9	-1.0	1.2	-3.5	0.5
Arm fat mass (left)	1.4	5.7	8.0	-2.8	-2.7	-1.9	-2.8	-2.7	-1.3	2.7	2.8	-2.2	-0.3	-2.7
Number of self-reported non-cancer illnesses	3.0	5.2	8.9	-2.8	-2.3	-1.7	-2.9	-2.2	-1.2	2.3	2.5	-3.0	-0.2	-2.4
Average weekly champagne plus white wine intake	3.1	4.3	6.4	2.3	2.2	2.3	2.4	2.3	2.0	-1.8	-1.3	2.5	1.5	1.9
Miserableness	0.1	0.1	0.4	0.1	-0.1	-0.4	0.5	-0.2	-0.6	-0.1	0.1	0.1	-0.4	-0.0
Guilty feelings	0.4	0.7	2.0	0.5	0.6	-0.2	0.6	0.5	-1.1	-1.2	-0.8	-0.4	-1.4	0.9
Wears glasses or contact lenses	0.4	0.5	2.0	-0.0	0.3	1.3	0.2	0.3	1.2	0.1	0.1	0.1	1.4	-0.0
Ever taken oral contraceptive pill	3.3	3.6	7.2	2.7	1.7	0.4	2.0	1.7	-0.7	-2.3	-2.3	1.9	-1.7	2.2
Hearing aid user	0.7	0.8	1.9	-0.6	-1.1	-0.1	-0.3	-1.1	0.1	1.4	1.3	0.1	0.9	-1.3
Mother’s age at death	0.3	0.4	0.7	-0.7	-0.8	-0.6	-0.4	-0.8	-0.7	0.6	0.7	-0.1	-0.5	-0.6
Financial situation satisfaction	2.9	3.6	5.3	2.2	2.0	2.1	2.3	1.9	1.7	-1.7	-1.4	2.2	1.1	1.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	0.5	0.5	1.1	0.5	0.5	1.4	-0.1	0.0	-0.0	1.5	0.1
Commuting to job workplace: Public transport	0.9	1.1	1.6	1.0	1.2	1.3	1.1	1.1	0.8	-1.2	-1.1	1.1	0.4	1.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.4	0.5	0.1	-0.1	0.5	-0.0	-0.5	-0.3	-0.2	-0.5	0.6
Medication: Blood pressure	1.5	2.9	5.0	-2.0	-1.9	-1.4	-1.8	-2.0	-1.0	1.8	1.8	-2.2	-0.0	-1.8
Pain type(s) experienced in last month: Hip pain	3.2	4.1	5.7	-2.3	-2.2	-2.4	-2.2	-2.3	-2.1	1.7	1.7	-1.8	-1.4	-1.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	0.9	0.9	1.2	1.3	0.8	1.0	-0.7	-0.7	1.2	0.7	0.8
High cholesterol (Self-reported)	0.8	1.5	4.8	0.3	1.1	1.9	-0.1	1.1	2.2	-0.4	-0.3	-0.6	2.0	0.6
Medication: Bendroflumethiazide	6.2	9.4	12.5	-3.1	-3.5	-3.2	-3.4	-3.5	-2.7	3.0	3.1	-3.1	-1.3	-3.2
Medication: Paracetamol	0.2	0.3	1.1	0.9	0.4	-0.2	1.1	0.4	-0.3	-0.6	-0.2	0.3	-0.5	0.5
Medication: Lisinopril	0.3	0.4	0.8	0.6	0.6	-0.0	0.3	0.7	-0.5	-0.9	-0.9	-0.2	-0.9	0.9
Medication: Atorvastatin	0.1	0.1	0.5	0.1	0.4	0.0	-0.1	0.4	0.2	-0.4	-0.7	-0.4	0.0	0.2
Illnesses of father: High blood pressure	1.8	2.3	4.3	-1.5	-1.3	-0.5	-1.6	-1.4	0.6	1.8	2.1	-1.9	1.3	-1.7
Alcohol drinker status: Never	1.1	1.3	4.3	-0.5	-0.8	-1.9	-0.6	-0.8	-2.0	-0.0	-0.1	-0.6	-2.1	-0.4
Ever smoked	0.0	0.1	0.2	0.3	0.2	0.4	0.3	0.3	0.3	-0.2	-0.1	-0.1	0.1	0.3
Basal metabolic rate	1.0	5.6	18.6	2.5	0.8	-1.5	1.7	0.8	-3.0	-2.3	-2.4	2.6	-4.3	1.9
Leg fat percentage (left)	0.6	2.3	4.2	-2.0	-1.5	-0.5	-1.7	-1.5	0.1	1.8	2.0	-1.7	0.8	-1.7
Arm fat-free mass (left)	1.3	6.4	18.7	2.9	1.2	-1.2	2.1	1.2	-2.9	-2.7	-2.6	2.8	-4.3	2.2
Number of operations (self-reported)	2.1	3.1	5.2	-1.6	-2.2	-2.1	-1.6	-2.3	-1.8	2.0	1.5	-0.8	-0.8	-2.0
Average weekly beer plus cider intake	0.5	0.7	1.2	-1.0	-1.0	-0.9	-1.1	-1.0	-0.5	1.0	0.8	-0.7	-0.4	-0.9
Irritability	0.1	0.1	0.3	0.3	0.2	0.3	0.6	0.2	0.6	-0.0	0.1	-0.4	0.5	0.0
Risk taking	0.2	0.4	0.9	-0.5	-0.3	-0.8	-0.8	-0.2	-0.9	0.0	0.0	-0.9	-0.8	-0.2
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.5	1.3	0.9	0.7	1.6	0.9	0.0	-1.2	-1.3	2.1	-0.9	1.4
Fractured/broken bones in last 5 years	0.0	0.1	0.2	0.2	0.2	0.4	0.1	0.2	0.2	-0.1	-0.3	-0.1	0.2	0.3
Age started oral contraceptive pill	0.0	0.1	0.5	0.0	-0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.0	0.7	-0.3	0.1
Diastolic blood pressure, automated reading	1.3	4.1	15.3	-1.0	-0.7	-2.9	-1.4	-0.7	-3.5	-0.7	-0.9	-2.1	-3.9	-0.1
Ever depressed for a whole week	0.7	0.9	1.7	1.3	0.6	-0.2	1.0	0.6	-0.8	-1.1	-1.1	0.9	-1.2	0.9
Unable to work because of sickness or disability	3.0	3.9	8.2	-2.0	-2.0	-0.1	-1.7	-2.1	0.9	2.9	2.6	-1.3	2.2	-2.5
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.7	0.6	0.9	0.3	0.5	1.0	-0.3	-0.4	1.2	0.8	0.5
Myopia	0.1	0.1	0.5	-0.4	0.1	0.5	0.1	0.0	0.5	0.1	0.2	-0.4	0.7	-0.2
Vascular/heart problems diagnosed by doctor	4.0	10.8	16.2	3.5	3.4	4.0	3.8	3.3	4.0	-2.3	-2.2	3.4	2.9	2.8
Cholesterol lowering medication	1.0	1.5	4.0	-1.4	-0.9	-0.1	-1.5	-1.0	0.5	1.2	1.4	-2.0	1.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.9	3.5	6.3	2.2	2.1	1.4	2.0	2.0	0.3	-2.5	-2.2	1.4	-0.6	2.3
Pain experienced in last month	0.1	0.1	0.2	0.4	-0.3	-0.2	0.2	-0.4	-0.4	0.1	0.3	0.2	-0.5	0.0
Supplements: Calcium	0.3	0.3	0.9	-0.8	-0.5	0.1	-0.2	-0.5	0.3	0.7	0.5	-0.5	0.9	-0.7
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	-0.7	-0.9	-0.6	-0.8	-0.8	-0.4	0.9	1.1	-0.1	0.1	-0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.2	0.2	0.4	-0.4	-0.1	0.4	-1.3	-1.2	-1.4	-0.2	-1.8	0.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.0	-1.3	-1.2	-1.7	-1.1	-1.2	-1.7	0.6	0.6	-1.3	-1.4	-0.9
Heart disease (siblings)	1.2	1.5	2.6	-1.3	-1.3	-1.5	-1.6	-1.2	-1.3	0.9	1.0	-0.9	-0.9	-1.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.0	-0.2	-0.2	0.3	-0.3	-0.1	0.2	0.0	-0.2	0.1	-0.4
Pack years of smoking	0.3	0.5	0.9	0.9	0.7	0.8	0.7	0.7	0.6	-0.6	-0.3	1.0	0.5	0.7
Impedance of whole body	5.5	28.0	38.1	5.7	6.2	4.9	5.6	6.1	3.5	-5.9	-5.3	5.6	1.0	6.1
Leg fat mass (left)	0.5	1.8	2.5	-1.6	-1.5	-1.3	-1.6	-1.5	-1.1	1.3	1.4	-1.2	-0.7	-1.4
Arm predicted mass (left)	1.3	6.6	18.7	2.9	1.2	-1.2	2.2	1.2	-2.9	-2.7	-2.6	2.9	-4.3	2.3