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chr3:127,639,072-129,574,472

Best TWAS P=1.75e-24 · Best GWAS P=1.07e-35 conditioned to 2.14e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Aorta	RAB7A	0.13	0.00	enet	21	0.08	5.6e-05	5.0	-10.2	1.7e-24	0.56	0.02	0.73	TRUE
12	METSIM	Adipose	RPN1	0.07	0.05	blup	362	0.05	2.3e-08	6.1	-9.4	6.2e-21	0.66	0.32	0.68	TRUE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC90246	0.09	0.09	lasso	4	0.10	4.1e-11	-6.5	7.6	3.3e-14	-0.12	0.05	0.95	TRUE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLXND1	0.08	0.06	blup	55	0.08	1.8e-09	-3.8	-5.3	9.8e-08	-0.07	0.21	0.78	TRUE
3	GTEx	Artery Aorta	RPN1	0.17	0.06	enet	27	0.07	9.7e-05	-5.3	-9.9	6.5e-23	0.81	0.02	0.97	FALSE
6	GTEx	Brain Cortex	RPN1	0.30	0.14	lasso	5	0.15	7.0e-05	-9.8	-7.8	5.5e-15	0.68	0.08	0.56	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC90246	0.06	0.06	enet	8	0.05	1.1e-05	-6.5	6.6	3.3e-11	-0.12	0.04	0.96	FALSE
5	GTEx	Brain Cerebellum	RAB7A	0.24	0.02	enet	23	0.05	1.6e-02	-4.1	-6.6	3.7e-11	0.58	0.03	0.53	FALSE
15	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPN1	0.10	0.02	blup	59	0.02	3.6e-02	-7.0	-6.6	4.3e-11	0.72	0.06	0.38	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	LOC90246	0.08	0.04	lasso	3	0.04	5.8e-05	-6.0	6.5	5.8e-11	-0.17	0.06	0.82	FALSE
4	GTEx	Artery Tibial	RPN1	0.12	0.07	lasso	4	0.05	1.3e-04	-5.3	-6.2	5.3e-10	0.80	0.10	0.89	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RPN1	0.11	0.12	lasso	2	0.12	1.0e-14	6.1	-6.2	7.7e-10	0.46	1.00	0.00	FALSE
8	GTEx	Esophagus Muscularis	RPN1	0.19	0.11	lasso	6	0.10	7.3e-07	-5.3	-5.8	5.0e-09	0.76	0.75	0.20	FALSE
10	GTEx	Testis	RPN1	0.30	0.15	enet	22	0.15	2.8e-07	-5.3	-5.4	5.7e-08	0.75	0.02	0.98	FALSE
9	GTEx	Lung	RPN1	0.08	0.06	lasso	4	0.04	2.6e-04	-5.3	-5.3	1.4e-07	0.75	0.26	0.54	FALSE
11	GTEx	Thyroid	RPN1	0.16	0.04	lasso	3	0.08	1.0e-06	-5.3	-5.2	1.8e-07	0.73	0.38	0.62	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	RPN1	0.13	0.10	lasso	3	0.08	9.9e-04	-5.3	-5.1	2.9e-07	0.77	0.04	0.89	FALSE