Best TWAS P=1.75e-24 · Best GWAS P=1.07e-35 conditioned to 2.14e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RPN1 | 0.11 | 0.12 | lasso | 2 | 0.12 | 1.0e-14 | 6.1 | -6.2 | 7.7e-10 | 0.46 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | RAB7A | 0.13 | 0.00 | enet | 21 | 0.08 | 5.6e-05 | 5.0 | -10.2 | 1.7e-24 | 0.56 | 0.02 | 0.73 | TRUE |
| 3 | GTEx | Artery Aorta | RPN1 | 0.17 | 0.06 | enet | 27 | 0.07 | 9.7e-05 | -5.3 | -9.9 | 6.5e-23 | 0.81 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Artery Tibial | RPN1 | 0.12 | 0.07 | lasso | 4 | 0.05 | 1.3e-04 | -5.3 | -6.2 | 5.3e-10 | 0.80 | 0.10 | 0.89 | FALSE |
| 5 | GTEx | Brain Cerebellum | RAB7A | 0.24 | 0.02 | enet | 23 | 0.05 | 1.6e-02 | -4.1 | -6.6 | 3.7e-11 | 0.58 | 0.03 | 0.53 | FALSE |
| 6 | GTEx | Brain Cortex | RPN1 | 0.30 | 0.14 | lasso | 5 | 0.15 | 7.0e-05 | -9.8 | -7.8 | 5.5e-15 | 0.68 | 0.08 | 0.56 | FALSE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | RPN1 | 0.13 | 0.10 | lasso | 3 | 0.08 | 9.9e-04 | -5.3 | -5.1 | 2.9e-07 | 0.77 | 0.04 | 0.89 | FALSE |
| 8 | GTEx | Esophagus Muscularis | RPN1 | 0.19 | 0.11 | lasso | 6 | 0.10 | 7.3e-07 | -5.3 | -5.8 | 5.0e-09 | 0.76 | 0.75 | 0.20 | FALSE |
| 9 | GTEx | Lung | RPN1 | 0.08 | 0.06 | lasso | 4 | 0.04 | 2.6e-04 | -5.3 | -5.3 | 1.4e-07 | 0.75 | 0.26 | 0.54 | FALSE |
| 10 | GTEx | Testis | RPN1 | 0.30 | 0.15 | enet | 22 | 0.15 | 2.8e-07 | -5.3 | -5.4 | 5.7e-08 | 0.75 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Thyroid | RPN1 | 0.16 | 0.04 | lasso | 3 | 0.08 | 1.0e-06 | -5.3 | -5.2 | 1.8e-07 | 0.73 | 0.38 | 0.62 | FALSE |
| 12 | METSIM | Adipose | RPN1 | 0.07 | 0.05 | blup | 362 | 0.05 | 2.3e-08 | 6.1 | -9.4 | 6.2e-21 | 0.66 | 0.32 | 0.68 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC90246 | 0.09 | 0.09 | lasso | 4 | 0.10 | 4.1e-11 | -6.5 | 7.6 | 3.3e-14 | -0.12 | 0.05 | 0.95 | TRUE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLXND1 | 0.08 | 0.06 | blup | 55 | 0.08 | 1.8e-09 | -3.8 | -5.3 | 9.8e-08 | -0.07 | 0.21 | 0.78 | TRUE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RPN1 | 0.10 | 0.02 | blup | 59 | 0.02 | 3.6e-02 | -7.0 | -6.6 | 4.3e-11 | 0.72 | 0.06 | 0.38 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC90246 | 0.06 | 0.06 | enet | 8 | 0.05 | 1.1e-05 | -6.5 | 6.6 | 3.3e-11 | -0.12 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC90246 | 0.08 | 0.04 | lasso | 3 | 0.04 | 5.8e-05 | -6.0 | 6.5 | 5.8e-11 | -0.17 | 0.06 | 0.82 | FALSE |