TWAS hub - RAB7A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1300	0.0520	0.00220	0.020	NA	0.012	NA	0.014	8.8e-03	NA	3.4e-02	NA	2.3e-02
2	GTEx	Artery Aorta	0.1250	0.0510	0.00470	0.000	NA	0.076	NA	0.021	3.1e-01	NA	5.6e-05	NA	2.4e-02
3	GTEx	Brain Cerebellum	0.2400	0.0880	0.00990	0.021	NA	0.047	NA	0.009	8.0e-02	NA	1.6e-02	NA	1.7e-01
4	GTEx	Nerve Tibial	0.1840	0.0717	0.00190	0.089	NA	0.133	NA	0.132	7.7e-07	NA	1.2e-09	NA	1.5e-09
5	YFS	Blood	0.0287	0.0116	0.00036	0.000	0.015	0.011	0.013	0.004	2.1e-01	8.5e-06	8.6e-05	2.2e-05	1.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Eosinophil Count	9.3	71.4	263.4	-2.0	16.2	-5.0	7.1	-3.9
Hearing difficulty/problems with background noise	8.5	13.7	16.6	3.8	4.0	2.9	4.1	-3.6
Number of full brothers	4.8	6.0	11.1	-2.5	-3.3	-2.6	-2.5	-0.3
Ever had hysterectomy (womb removed)	4.3	4.8	10.7	1.8	3.3	1.3	1.9	-2.2
Blood White Count	4.2	31.0	104.0	-1.4	-10.2	-6.6	0.5	2.2
Pulse wave Arterial Stiffness index	4.2	4.9	9.4	2.2	2.2	1.4	3.1	-1.9
Hand grip strength (right)	4.0	10.9	18.2	-4.3	-3.3	-2.1	-4.1	2.1
Rheumatoid Arthritis	3.8	5.3	15.5	1.4	3.9	1.9	2.1	0.7
Pulse wave peak to peak time	3.8	4.5	8.9	-2.1	-2.1	-1.4	-3.0	1.7
Hearing difficulty/problems: Yes	3.7	5.6	8.2	2.3	2.1	1.8	2.9	-2.6
Mean Putamen Volume	3.6	4.1	10.8	-1.3	-3.3	-2.3	-1.6	0.4
Prostate Cancer	3.5	4.9	15.9	2.7	4.0	0.4	1.1	0.3
Lung FEV1/FVC ratio	3.1	15.8	26.2	4.1	5.1	-1.9	3.6	4.3
Medication: Metformin	3.1	4.4	9.5	2.4	1.8	0.4	1.8	-3.1
Myopia	3.0	4.4	6.1	-1.6	-2.2	-1.8	-2.4	2.5
Handedness (chirality/laterality): Left-handed	2.9	3.5	6.1	1.6	1.5	2.5	0.8	-2.4
Ever depressed for a whole week	2.9	3.6	5.9	1.4	2.4	1.4	2.0	-2.0
Hand grip strength (left)	2.7	7.0	14.8	-3.4	-2.5	-0.9	-3.9	1.1
Falls in the last year	2.6	3.6	6.2	2.5	1.8	1.8	2.2	-0.6
Medication: Gliclazide	2.5	2.8	5.0	2.2	1.6	0.5	2.0	-1.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.3	1.6	2.1	1.3	1.8	-1.4
Diabetes (mother)	2.2	2.8	5.4	-1.8	-1.4	-2.3	-1.8	0.5
Friendships satisfaction	2.2	2.7	11.3	-0.3	0.2	0.2	1.4	-3.4
Had major operations	2.1	2.4	4.1	0.0	1.9	1.5	1.5	-2.0
Smoking status: Previous	2.1	3.2	8.4	1.4	0.5	0.7	2.2	-2.9
Financial situation satisfaction	2.1	2.6	7.8	0.8	0.6	1.4	1.4	-2.8
Stomach or abdominal pain in last month	2.0	2.5	6.7	0.5	0.6	2.1	0.6	-2.6
Impedance of arm (right)	2.0	9.5	20.6	3.7	4.5	2.5	2.6	0.5
Townsend deprivation index at recruitment	1.9	2.6	5.6	1.5	0.1	0.5	2.3	-2.4
Past tobacco smoking	1.9	3.5	8.8	-1.1	-0.3	-0.9	-2.5	3.0
Depression (self-reported)	1.9	2.3	5.0	2.2	1.2	0.6	2.0	-0.9
Ever had prostate specific antigen (PSA) test	1.9	2.2	8.5	1.1	2.9	0.6	0.8	-0.2
Alzheimer’s Disease (including proxy)	1.8	2.6	6.0	-0.0	1.5	2.4	1.1	-1.9
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	7.8	1.1	1.4	-0.5	2.8	-0.7
Diabetes (father)	1.8	2.2	5.5	2.3	1.6	-0.0	1.8	0.1
Serious illness, injury or assault to yourself	1.8	2.2	4.2	1.7	0.3	1.9	2.1	0.1
Impedance of arm (left)	1.8	8.3	18.4	2.9	4.3	2.5	2.8	0.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	7.6	-1.8	-1.0	-1.6	0.0	2.8
Birth weight	1.8	3.9	10.9	-1.3	-2.0	-3.3	-1.1	1.3
Risk taking	1.8	2.6	7.8	1.2	0.6	0.4	2.8	-1.7
Fluid intelligence score	1.7	3.5	4.7	1.4	1.7	1.8	2.2	-2.1
Length of working week for main job	1.7	1.9	2.9	1.7	0.8	1.5	1.3	-1.3
Long-standing illness, disability or infirmity	1.7	2.7	6.8	0.9	-0.2	1.2	2.6	-2.0
Ever had bowel cancer screening	1.7	2.0	4.3	2.1	0.4	1.1	1.6	-1.5
Wears glasses or contact lenses	1.7	1.9	5.9	0.3	0.6	1.7	0.7	-2.4
Number of incorrect matches in round	1.6	2.7	6.7	1.1	1.8	2.6	1.1	-1.0
Mouth/teeth dental problems: Loose teeth	1.6	2.0	4.9	1.5	0.8	1.0	2.2	-0.9
Heart disease (mother)	1.6	1.9	4.7	1.1	0.6	1.2	1.3	-2.2
Loneliness, isolation	1.6	2.2	3.9	1.3	0.6	2.0	1.4	-1.7
Number of operations (self-reported)	1.6	2.3	7.8	0.7	0.3	0.1	2.8	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	5.2	-2.3	-1.9	-0.7	-0.7	-0.7
Major Depression (MDD)	1.5	1.8	4.7	0.6	2.2	0.7	1.7	-0.6
Blood Platelet Count	1.5	17.3	73.6	-2.5	-0.5	2.2	-1.2	-8.6
Cardiovascular Disease	1.5	4.9	12.5	-2.7	-3.5	-1.8	-0.5	-1.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	0.8	1.6	1.2	2.0	-0.7
Qualifications: CSEs or equivalent	1.5	1.9	4.4	-1.4	-1.7	-0.5	-0.4	2.1
Chronic bronchitis/emphysema (father)	1.5	1.8	5.9	0.8	0.3	0.1	1.5	-2.4
High blood pressure (siblings)	1.5	2.2	5.6	-0.5	-2.4	-0.4	-0.7	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.7	0.2	1.6	2.2	1.0	-0.8
Supplements: Vitamin C	1.5	1.8	2.7	1.5	1.2	1.3	1.6	0.9
Knee pain experienced in last month	1.5	2.4	5.7	1.2	0.7	0.3	2.4	-2.1
Diabetes diagnosed by doctor	1.5	2.4	4.2	1.9	1.2	0.7	1.5	-2.0
Impedance of whole body	1.5	7.6	18.8	2.6	4.3	3.0	1.9	0.4
Depressed Affect (Nagel 2018)	1.4	2.8	3.5	1.6	1.6	1.7	1.6	-1.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.0	1.5	1.7	1.0	1.3	-0.4
Illnesses of siblings	1.4	1.9	5.7	-0.0	2.4	0.5	1.1	1.6
Birth weight of first child	1.4	2.6	5.9	2.4	2.0	-0.5	0.8	1.5
Shortness of breath walking on level ground	1.4	1.6	5.0	1.1	0.6	0.4	2.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	5.9	-2.3	-0.8	-0.9	-2.4	1.4
Ever smoked	1.4	2.5	7.1	-0.2	-0.4	0.3	2.2	-2.7
Average weekly beer plus cider intake	1.4	2.0	3.5	-1.6	-1.8	-1.9	0.7	-0.9
Irritability	1.4	2.4	3.6	1.4	1.2	1.9	1.3	-1.8
Basal cell carcinoma (self-reported)	1.4	1.7	3.1	1.5	1.7	1.8	0.5	0.1
Impedance of leg (right)	1.3	6.4	15.8	2.5	4.0	3.0	1.0	-0.6
High blood pressure	1.3	3.5	9.7	-1.8	-2.1	-0.2	0.5	-3.1
Impedance of leg (left)	1.3	6.2	15.8	2.1	4.0	3.2	0.7	-0.6
Forced vital capacity (FVC)	1.3	4.8	8.4	-2.6	-2.0	-1.7	-2.9	1.4
Mouth/teeth dental problems	1.3	1.9	3.5	-1.6	-0.3	-0.2	-1.8	1.9
Pulse wave reflection index	1.3	1.6	2.7	1.6	1.4	1.5	0.3	-1.0
Blood clot in the leg (DVT)	1.3	1.7	4.6	-2.1	-1.7	-0.5	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.8	-1.5	-0.9	-0.6	-2.1	2.4
Alzheimer’s Disease (in mother)	1.2	1.4	3.9	0.1	1.1	2.0	1.3	-0.5
LDL Cholesterol	1.2	2.0	3.0	1.0	1.4	1.7	1.6	1.1
Average weekly spirits intake	1.2	1.4	2.6	-1.6	-1.6	-0.0	-1.3	-0.6
Waist circumference	1.2	4.2	11.8	-1.2	-3.4	-2.5	0.2	-1.4
Alcohol usually taken with meals	1.2	2.0	5.5	1.4	0.9	-1.0	-0.7	2.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.4	-1.6	-0.1	1.0	-0.1	1.8
Mean time to correctly identify matches	1.2	2.2	5.2	1.9	1.5	-0.5	2.3	0.0
Family relationship satisfaction	1.2	1.5	5.1	0.2	-0.6	-0.2	1.3	-2.3
Mood swings	1.2	2.2	4.4	1.4	1.7	1.2	2.1	-0.7
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	0.1	-0.5	1.1	1.7	-2.5
Eye problems/disorders: Glaucoma	1.2	1.4	4.8	-2.2	-1.4	-0.4	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.4	-2.1	-1.0	0.8	-1.3	-0.5
Crohns Disease (2012)	1.1	1.8	3.2	-1.8	-0.6	-1.8	-1.1	1.1
BMI	1.1	6.7	19.3	-1.9	-4.4	-3.2	0.0	0.0
Respiratory disease	1.1	2.4	3.4	-1.9	-1.3	1.6	-1.2	-1.8
Medication: Co-codamol	1.1	1.2	3.7	0.5	-1.1	-0.9	0.4	-1.9
Body mass index (BMI)	1.1	4.8	14.4	-1.6	-3.8	-2.5	0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.2	2.0	2.0	0.2	0.5	-0.6
Headache pain in last month	1.1	1.8	5.1	1.3	2.3	1.3	0.7	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	5.3	0.2	0.2	2.3	0.8	-1.0
Hypertension (Self-reported)	1.1	3.0	8.6	-1.3	-1.9	-0.4	1.0	-2.9
Leg fat-free mass (right)	1.1	5.6	10.7	-2.0	-3.3	-3.2	-1.4	1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	4.4	-0.3	1.4	0.7	-0.5	2.1
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.8	0.7	-1.4	-1.7	0.8	-0.9
Arm predicted mass (left)	1.1	5.7	9.9	-2.4	-3.1	-2.7	-2.2	-0.3
Schizophrenia (2018)	1.0	2.1	4.2	-1.5	-1.6	-1.1	-2.1	0.4
Primary Biliary Cirrhosis	1.0	1.4	3.4	1.4	-0.7	-0.8	1.8	0.8
Leg fat-free mass (left)	1.0	5.3	10.9	-1.7	-3.2	-3.3	-1.2	1.0
Age when periods started (menarche)	1.0	2.3	4.5	0.9	2.1	1.2	0.9	1.9
Had other major operations	1.0	1.2	3.7	-0.0	-0.6	-0.7	1.9	-1.2
Time employed in main current job	1.0	1.2	3.7	-0.1	0.6	0.8	-1.0	-1.9
Happiness	1.0	1.2	2.4	-1.6	-0.8	-1.0	0.5	-1.3
Medication: Lansoprazole	1.0	1.2	3.9	-0.0	-1.3	-2.0	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.8	1.4	0.7	-1.4	1.7	0.3
Arm fat-free mass (right)	1.0	5.3	9.9	-2.4	-3.1	-2.6	-1.9	0.0
Medication: Blood pressure	1.0	1.7	6.0	0.6	0.2	0.7	1.3	-2.5
Arm predicted mass (right)	1.0	5.4	9.9	-2.5	-3.1	-2.7	-1.9	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	4.4	0.2	-0.9	0.4	2.1	-0.4
Mineral and other dietary supplements	1.0	1.4	2.7	1.6	0.8	-1.0	1.6	-0.1
Leg predicted mass (right)	1.0	5.3	10.2	-1.9	-3.2	-3.1	-1.4	1.0
Arm fat-free mass (left)	1.0	5.0	9.9	-2.1	-3.1	-2.5	-2.0	-0.5
Vascular/heart problems diagnosed by doctor	1.0	2.8	8.0	1.6	1.8	0.1	-0.7	2.8
Intelligence (Savage-Jansen 2018)	0.9	2.8	4.9	2.2	2.0	1.1	1.8	-0.7
Alzheimer’s Disease (in father)	0.9	1.0	2.6	0.2	0.3	0.9	1.1	-1.6
Neuroticism	0.9	2.1	2.9	1.6	1.7	1.1	1.6	-1.1
Medication: Levothyroxine sodium	0.9	1.5	3.5	-1.1	-1.2	-1.9	-0.4	1.1
Leg predicted mass (left)	0.9	5.0	10.3	-1.7	-3.1	-3.2	-1.1	1.0
Pain all over the body in last month	0.9	1.0	2.2	0.8	0.9	0.6	0.9	-1.5
Medication: Amlodipine	0.9	1.3	3.6	0.1	-1.9	0.6	0.3	-1.6
Emphysema/chronic bronchitis	0.9	1.1	2.2	1.0	0.7	1.5	0.9	0.9
Whole body fat-free mass	0.9	5.1	9.6	-2.1	-3.1	-3.0	-1.7	0.4
Whole body water mass	0.9	5.3	10.2	-2.2	-3.2	-2.9	-1.7	0.4
Arm fat mass (left)	0.9	3.7	10.6	-1.3	-3.2	-2.3	0.2	-0.8
Average weekly champagne plus white wine intake	0.9	1.3	3.7	1.1	0.8	-0.3	1.9	0.8
Basal metabolic rate	0.9	5.0	9.9	-2.0	-3.1	-3.0	-1.5	0.2
Unable to work because of sickness or disability	0.9	1.2	2.5	0.8	-0.4	1.6	0.6	-1.5
Heart disease (siblings)	0.9	1.2	3.2	-0.1	-0.6	-1.8	-0.7	-1.3
Leg fat mass (left)	0.9	3.3	8.9	-1.1	-3.0	-2.3	-0.2	-1.0
Fasting Glucose	0.8	1.0	2.4	1.5	-0.1	0.1	1.2	-1.0
Heel T-Score	0.8	6.3	13.9	2.5	3.7	2.6	0.5	-2.0
Systolic Blood Pressure	0.8	4.0	7.8	-1.9	-2.8	-0.7	-1.6	-2.2
Lung FVC	0.8	4.1	5.8	-2.3	-2.3	-0.9	-2.4	-1.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.3	1.5	-0.0	-0.8	0.7	-0.8
Maternal smoking around birth	0.8	1.2	2.5	-0.8	-1.5	-0.6	0.3	1.6
Taking other prescription medications	0.8	1.3	2.9	0.6	-0.0	0.3	1.7	-1.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	1.1	0.6	1.5	1.0	-0.3
Medication: Atenolol	0.8	1.0	2.2	-1.5	-1.4	-0.3	-0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.7	1.2	1.7	-0.3	1.4	-0.2
Medication: Ramipril	0.8	1.0	4.4	0.4	0.1	0.4	0.7	-2.1
Neuroticism score	0.8	1.7	3.1	1.4	1.8	0.9	1.5	-0.7
Weight	0.8	4.0	10.0	-1.4	-3.2	-2.8	-0.6	-0.5
Trunk fat-free mass	0.8	4.9	8.6	-2.1	-2.9	-2.7	-2.0	0.1
Trunk predicted mass	0.8	4.8	8.7	-2.1	-3.0	-2.6	-2.0	0.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.2	1.5	0.3	-0.9	1.1	0.8
Forced vital capacity (FVC), Best measure	0.8	3.0	7.4	-2.4	-1.0	-0.7	-2.7	0.6
Medication: Ibuprofen	0.8	0.9	3.2	-0.3	-0.4	-1.8	-0.6	-0.9
Leg fat mass (right)	0.8	3.2	8.0	-0.7	-2.8	-2.5	0.2	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.8	0.7	0.6	1.0	1.7	-0.2
Medication: Blood pressure	0.8	1.6	3.8	-1.2	-1.9	-0.1	0.5	-1.5
Irritable Bowel Disease (IBD)	0.7	1.6	4.5	-0.6	-0.4	-2.1	-1.2	1.1
Reaction Time	0.7	1.3	2.9	1.3	1.1	-0.7	1.7	0.3
Triglycerides	0.7	1.2	2.6	1.4	-0.2	-1.6	-0.5	1.0
Supplements: Zinc	0.7	0.7	1.3	1.1	1.2	0.5	0.9	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	0.5	0.4	-1.3	-0.7	1.4
Diabetes (self-reported)	0.7	1.1	2.3	1.5	0.6	0.3	0.9	-1.5
Father’s age at death	0.7	0.9	2.9	-1.7	-0.4	0.4	-0.4	-1.0
Prospective memory result	0.7	0.8	2.3	-0.9	-1.5	0.4	-0.8	0.4
Arm fat mass (right)	0.7	3.1	8.6	-0.9	-2.9	-2.1	0.6	-1.0
Loud music exposure frequency	0.7	0.8	1.8	-0.5	-1.4	-1.1	-0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.2	1.1	0.4	-1.0	1.5	-0.6
Migraine (self-reported)	0.7	0.9	1.9	1.0	0.6	1.4	-0.0	-1.2
Medication: Seretide 50 evohaler	0.7	0.8	3.0	0.4	0.5	1.7	-0.1	-0.7
Overall health rating	0.7	1.5	5.3	-0.5	-0.7	0.1	1.2	-2.3
Leg pain on walking	0.7	0.9	1.3	-0.8	-1.1	-1.1	-0.5	-1.1
Depression (Nagel 2018)	0.6	0.9	2.1	-0.1	0.2	1.2	0.8	-1.5
Crohns Disease (2017)	0.6	1.3	4.8	-0.6	-0.5	-2.2	-0.9	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	1.9	1.2	1.4	0.9	1.3	-1.2
Age at First Birth	0.6	0.9	2.5	-0.4	0.2	-1.1	-1.6	0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.0	0.8	0.4	-0.4	0.6	1.4
HbA1C	0.6	0.7	1.7	1.3	0.8	-0.2	1.1	-0.1
HDL Cholesterol	0.6	1.0	1.9	0.6	0.6	1.4	1.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	-1.0	-1.4	0.7	0.1	0.2
Waist Hip Ratio (WHR)	0.6	2.6	5.2	-1.5	-2.3	-2.1	-0.6	-1.0
Smoking Status	0.6	1.4	4.1	0.1	-0.2	1.0	2.0	-1.3
Severe depression (siblings)	0.6	0.6	2.1	-0.2	0.5	0.9	1.4	0.1
High blood pressure (mother)	0.6	0.8	2.4	-0.2	-0.8	0.8	0.5	-1.5
Allergy	0.6	1.4	3.0	1.3	0.4	-1.0	1.0	1.7
Arm fat percentage (right)	0.6	2.3	4.7	0.1	-2.2	-1.8	1.5	-1.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.2	-1.1	0.0	-1.7	-1.8	1.6
Pulse rate	0.6	1.1	4.0	0.6	0.5	-0.7	2.0	-0.5
Asthma	0.6	1.2	2.6	-1.0	-1.1	1.0	-0.3	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.9	-0.0	-0.1	-1.7	-0.4	-0.7
Peak expiratory flow (PEF)	0.6	1.4	4.2	-1.2	-0.8	-2.0	-0.8	-0.1
Wheeze or whistling in the chest in last year	0.6	1.1	2.7	-0.7	-1.2	-0.8	-0.4	-1.6
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	0.7	1.4	0.1	0.6	1.6
Medication: Omeprazole	0.6	0.7	1.7	0.9	0.2	1.3	0.9	-0.4
Whole body fat mass	0.6	2.5	6.5	-0.6	-2.5	-2.2	0.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.5	-0.4	0.4	-0.4	1.6	-0.8
Medication: Aspirin	0.6	0.8	1.5	-1.2	-0.7	-1.0	-0.7	-0.7
Arm fat percentage (left)	0.6	2.5	6.1	-0.4	-2.5	-1.8	1.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	1.5	0.6	-0.4	0.7	0.2
Medication for cholesterol	0.6	1.0	2.2	0.6	1.5	0.3	-1.2	0.7
Osteoarthritis (self-reported)	0.6	0.8	1.8	1.1	0.4	-0.6	1.4	-0.6
Miserableness	0.6	1.1	2.5	1.1	1.6	0.8	1.0	-0.6
Medication: Lisinopril	0.6	0.7	1.6	0.2	0.6	1.3	0.8	-1.0
Cholesterol lowering medication	0.6	0.8	1.9	-0.6	-1.4	-0.6	1.3	-0.0
Neuroticism (Nagel 2018)	0.5	1.3	1.6	1.3	1.0	1.2	1.2	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	2.1	-0.6	-0.7	-0.9	-1.4	0.1
Ulcerative Colitis (UC)	0.5	1.0	2.2	-0.5	-0.0	-1.3	-1.1	1.5
Blood Red Count	0.5	5.3	11.8	2.2	2.5	1.8	3.4	-0.3
Number of treatments/medications taken	0.5	0.9	2.8	-0.5	-0.8	-0.5	0.7	-1.7
Systolic blood pressure, automated reading	0.5	1.5	3.7	-0.7	-1.9	0.1	0.1	-1.8
Angina	0.5	0.6	2.0	-0.4	-0.1	-0.0	-1.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	1.0	1.5	1.3	-0.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	0.5	0.9	1.2	-0.1	-0.9
Hair/balding pattern: Pattern 3	0.5	0.7	2.0	0.3	0.5	1.4	0.8	-0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	2.1	-0.1	-1.0	0.5	1.0	-1.4
Lung cancer (father)	0.5	0.6	1.0	-0.2	0.7	0.8	1.0	1.0
Exposure to tobacco smoke at home	0.5	0.5	0.9	-0.2	-0.9	-0.9	-0.5	-0.7
Number of children fathered	0.5	0.6	1.5	-1.2	-0.4	0.2	0.7	-0.7
Age at first live birth	0.5	0.8	1.7	1.3	1.3	0.1	0.2	0.8
Health satisfaction	0.5	0.6	2.0	-1.4	-0.5	0.4	0.3	-0.7
Qualifications: College or University degree	0.5	1.5	2.7	1.6	1.5	1.6	0.4	0.0
Neck or shoulder pain in last month	0.5	0.8	2.7	1.6	0.3	0.1	0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-1.0	-0.9	-0.5	-0.9	0.3
Alcohol intake frequency.	0.5	1.2	3.3	-0.4	-0.2	1.5	-1.8	-0.5
Commuting to job workplace: Walk	0.5	0.6	1.5	1.0	-0.5	-1.2	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.8	0.6	0.8	0.1	-0.1	-1.7
Asthma (self-reported)	0.5	1.0	2.6	-0.4	-0.8	1.3	-0.1	-1.6
Hearing aid user	0.5	0.6	1.6	0.1	-0.4	-1.0	0.0	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.1	1.4	0.8	0.3	0.6	-0.2
Alcohol drinker status: Never	0.5	0.6	2.0	1.4	0.6	-0.0	0.0	-0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.7	0.4	0.2	1.3	0.5	-0.9
Pack years of smoking	0.5	0.8	2.7	0.3	-0.6	-1.6	0.4	0.7
Schizophrenia (2014)	0.4	1.0	3.8	-0.7	-0.6	0.1	-1.9	-0.4
Ulcerative Colitis	0.4	0.5	2.5	-0.2	0.0	-0.2	-0.2	1.6
Hypothyroidism (self reported)	0.4	0.9	1.4	0.8	1.0	0.8	1.2	1.0
Medication for hormone replacement therapy	0.4	0.4	2.0	0.0	0.2	0.2	1.4	0.1
Pack years adult smoking proportion	0.4	0.6	1.8	0.5	-0.3	-1.4	0.6	0.6
Current tobacco smoking	0.4	0.6	1.7	-0.4	0.4	1.0	1.3	-0.0
Fed-up feelings	0.4	0.7	1.8	0.8	0.4	-1.3	0.7	-0.7
Multivitamins +/- minerals	0.4	0.5	1.5	0.1	1.2	0.1	0.2	-1.1
Trunk fat mass	0.4	1.8	4.2	-0.4	-2.1	-2.0	0.6	-0.4
Qualifications: None of the above	0.4	0.9	3.5	0.0	-0.7	-0.7	-0.2	-1.9
Financial difficulties in last 2 years	0.4	0.6	1.1	-1.0	-0.9	-0.8	-0.3	0.6
Heart attack	0.4	0.6	2.0	-0.4	-0.0	-0.7	0.2	-1.4
Alcohol intake versus 10 years previously	0.4	0.5	0.9	0.5	-1.0	0.7	0.4	-1.0
Noisy workplace	0.4	0.5	1.9	0.5	0.4	1.4	-0.2	0.0
Illnesses of mother	0.4	0.6	1.0	0.1	-0.5	-1.0	-0.7	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.6	-1.0	0.7	-0.9	-1.6	1.0
Tense / ‘highly strung’	0.4	0.7	2.0	0.2	1.0	1.4	-0.1	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	4.4	-2.1	-0.2	-0.2	-0.6	-0.5
Glaucoma (self-reported)	0.4	0.5	2.2	-1.5	-0.2	-0.3	-0.1	0.3
Body fat percentage	0.4	1.5	2.7	0.2	-1.6	-1.6	1.3	-0.7
Leg fat percentage (right)	0.4	1.6	3.3	-0.2	-1.8	-1.8	0.6	-1.1
Comparative body size at age 10	0.4	1.0	2.7	0.2	-1.2	-0.0	1.0	-1.6
Angina (self-reported)	0.4	0.5	1.8	-0.0	0.2	-0.1	-0.8	-1.4
Medication: Allopurinol	0.4	0.6	1.1	0.6	-0.8	-0.5	0.8	1.0
Pulse rate, automated reading	0.4	1.2	2.3	1.0	1.5	0.1	1.5	-0.5
Suffer from ‘nerves’	0.4	0.6	1.6	0.1	-0.2	-1.1	1.2	0.5
Chest pain or discomfort	0.4	0.6	1.1	0.9	0.9	-0.5	1.0	0.2
Age at last live birth	0.4	0.6	1.6	1.3	0.8	0.4	0.6	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.1	-0.3	-0.6	-0.7	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.8	0.7	-0.3	-0.6	0.5	1.4
Medication: Aspirin	0.4	0.5	0.9	-1.0	-0.5	-0.7	-0.2	-0.8
High cholesterol (Self-reported)	0.4	0.8	1.6	-1.3	-0.9	-0.6	0.6	0.8
Medication: Bendroflumethiazide	0.4	0.6	1.7	-0.5	-1.1	0.1	0.2	-1.3
Medication: Atorvastatin	0.4	0.4	1.0	0.3	1.0	0.9	0.5	-0.2
Leg fat percentage (left)	0.4	1.6	3.9	-0.6	-2.0	-1.6	0.2	-1.0
Age started oral contraceptive pill	0.4	0.6	2.0	-0.2	-0.5	-1.4	-0.6	-0.3
Commuting to job workplace: Cycle	0.4	0.5	1.5	-1.2	-0.8	-0.2	0.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.6	-0.5	1.0	1.1	-0.1
Supplements: Calcium	0.4	0.5	0.9	0.9	0.6	-0.3	0.9	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	-0.6	-0.9	-0.6	-1.6	-0.1
Ovarian Cancer	0.3	0.4	1.1	0.5	-0.5	-1.1	0.1	-0.3
Body Mass Index (BMI) (2010)	0.3	0.3	1.1	0.7	0.0	-1.0	-0.0	0.4
Neuroticism (2016)	0.3	0.4	1.2	-0.4	-0.2	0.0	-0.9	1.1
Allergy or Eczema	0.3	0.9	1.4	-0.8	1.0	0.2	-1.2	-1.2
Relative age of first facial hair	0.3	0.6	1.2	0.3	1.1	0.5	-0.7	1.1
Trunk fat percentage	0.3	1.1	2.0	0.2	-1.3	-1.4	1.3	-0.2
Relative age voice broke	0.3	0.4	1.5	0.5	-0.1	0.4	-1.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.4	0.7	1.2	0.9	-1.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.0	0.7	-0.1	1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.3	1.1	0.5	-0.2	-1.2
Sitting height	0.3	1.9	3.8	-1.5	-0.6	-1.6	-1.9	0.4
Medication: Simvastatin	0.3	0.5	1.0	-0.4	-0.8	-0.6	1.0	0.5
Hip circumference	0.3	1.3	3.9	-0.5	-2.0	-1.2	1.0	-0.5
Worrier / anxious feelings	0.3	0.5	1.4	0.2	1.2	1.0	-0.1	-0.2
Breastfed as a baby	0.3	0.4	1.0	-1.0	0.0	-0.4	-0.2	1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.6	0.6	-0.5	1.0	-0.3
Medication: Paracetamol	0.3	0.5	1.5	1.2	0.2	0.9	0.2	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.3	-0.0	-0.2	-0.1	-0.9	1.1
Gout (self-reported)	0.3	0.5	1.4	-0.4	0.0	-1.2	0.3	0.8
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.6	-0.4	1.0	-0.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.2	-1.1	-0.3	-0.2	-0.7	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.9	0.1	-0.5	0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.7	0.1	-1.3	-0.3	-0.3	-0.3
Back pain experienced in last month	0.3	0.4	0.9	0.1	-0.3	-0.9	-0.3	-1.0
Smoking status: Current	0.3	0.4	1.4	-0.3	0.4	0.7	1.2	0.1
Guilty feelings	0.3	0.4	0.7	0.7	0.4	0.1	0.8	-0.7
Commuting to job workplace: Public transport	0.3	0.4	1.7	0.5	0.4	1.3	0.2	-0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.7	-0.2	0.1	-0.6	0.1	-1.3
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	0.6	0.5	0.4	-0.6
Worry (Nagel 2018)	0.2	0.5	1.0	0.6	0.8	1.0	0.7	0.3
Lupus	0.2	0.3	0.7	-0.9	0.2	-0.4	0.3	-0.7
Chronotype (morning person)	0.2	0.4	1.2	-0.2	-0.0	-1.1	-0.7	0.5
Tanning	0.2	2.1	7.1	-1.4	-2.7	0.1	-1.2	-0.4
Sensitivity / hurt feelings	0.2	0.4	0.7	0.8	0.4	0.3	0.8	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.1	-0.7	-0.3	0.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.6	0.6	0.3	0.8	-0.4
Supplements: Glucosamine	0.2	0.3	0.9	0.0	-0.1	0.9	0.2	-0.7
Had menopause	0.2	0.2	0.7	-0.8	-0.6	0.3	0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	-0.5	-0.1	-0.6	-0.7	1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.6	0.5	0.5	0.8	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.8	0.5	0.2	0.1	0.9	-0.5
Worry too long after embarrassment	0.2	0.3	0.8	0.6	0.9	0.3	0.5	-0.1
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.4	0.6	0.4	-0.6	0.1
Number of full sisters	0.2	0.3	0.8	0.3	-0.1	-0.3	0.7	-0.9
Illnesses of father: Heart disease	0.2	0.3	1.5	-0.0	-0.5	0.1	-0.1	-1.2
Osteoporosis (self-reported)	0.2	0.3	0.8	0.1	0.4	0.9	-0.6	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.0	-0.8	0.0	0.7	0.0
Mother’s age at death	0.2	0.2	0.5	0.5	0.7	-0.4	-0.2	-0.3
Illnesses of father: High blood pressure	0.2	0.3	1.0	0.1	-0.2	0.6	-0.2	-1.0
Diastolic blood pressure, automated reading	0.2	0.5	1.4	-0.3	-0.5	-0.5	0.8	-1.2
Alcohol drinker status: Previous	0.2	0.3	0.6	0.3	-0.8	0.5	-0.2	0.6
Breast Cancer	0.1	0.2	0.5	0.7	0.5	-0.6	-0.0	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.4	0.3	0.5	-0.1	0.3
Height	0.1	2.1	4.5	0.8	1.9	1.1	-0.7	-2.1
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	0.5	0.1	-0.8	0.7	-0.2
Vitamin and mineral supplements	0.1	0.2	0.4	0.4	-0.7	-0.3	-0.2	-0.3
Average weekly fortified wine intake	0.1	0.1	0.3	-0.2	-0.2	0.6	0.0	0.0
Nervous feelings	0.1	0.3	0.9	0.4	0.5	0.1	-0.3	0.9
Number of live births	0.1	0.2	0.5	-0.3	0.3	0.4	0.4	-0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.5	-0.1	-0.5	0.4	-0.3
Standing height	0.1	0.7	1.8	0.0	0.7	-0.8	-1.3	0.8
Comparative height size at age 10	0.1	0.3	0.6	0.1	0.1	-0.8	-0.6	-0.7
Average weekly red wine intake	0.1	0.1	0.3	0.4	-0.2	-0.3	-0.6	-0.1
Breast cancer (self-reported)	0.1	0.1	0.3	0.2	-0.2	-0.1	0.2	-0.5
Medication: Paracetamol	0.1	0.1	0.4	0.4	-0.1	-0.3	0.1	0.7
Pain experienced in last month	0.1	0.2	0.6	-0.5	0.2	-0.2	-0.3	0.8
Hair Pigment	0.0	0.6	2.1	0.2	-0.1	-1.0	1.4	0.3

Hub : Genes

RAB7A

Models

Trait associations