TWAS hub - LOC90246

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.1120	0.0400	9.5e-07	0.080	0.088	0.074	NA	0.077	2.6e-07	6.5e-08	7.8e-07	NA	4.8e-07
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0870	0.0277	2.0e-09	0.094	0.085	0.086	NA	0.098	9.7e-11	8.2e-10	6.8e-10	NA	4.1e-11
3	TCGA	Prostate Adenocarcinoma	0.0632	0.0246	8.3e-06	0.058	0.031	0.047	NA	0.044	1.1e-06	2.8e-04	1.1e-05	NA	2.1e-05
4	TCGA	Thyroid Carcinoma	0.0760	0.0340	3.9e-04	0.038	0.027	0.032	NA	0.042	1.2e-04	1.0e-03	4.2e-04	NA	5.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Blood Eosinophil Count	30.2	233.0	405.6	-20.1	-10.0	-17.7	-10.7
Mean Putamen Volume	6.4	7.3	11.2	2.2	2.3	2.8	3.4
Blood White Count	5.1	37.4	57.5	2.3	7.6	6.6	6.5
Hearing aid user	4.9	5.6	6.4	2.0	2.5	2.5	2.4
Stomach or abdominal pain in last month	4.5	5.6	6.8	-2.5	-2.5	-2.6	-1.8
Breast cancer (self-reported)	4.4	5.3	9.6	1.6	2.1	2.1	3.1
Had other major operations	4.1	5.0	7.0	1.2	2.6	2.2	2.6
Chronic bronchitis/emphysema (father)	3.7	4.3	5.3	-2.1	-2.3	-2.2	-1.6
Diabetes (father)	3.6	4.4	6.0	1.8	1.8	2.3	2.4
Lung cancer (father)	3.5	4.0	6.9	-2.6	-2.0	-2.2	-0.8
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	5.0	1.5	1.8	2.1	2.2
Number of incorrect matches in round	3.3	5.5	11.6	-0.9	-2.4	-2.0	-3.4
Average weekly champagne plus white wine intake	3.3	4.5	5.5	2.1	2.0	2.3	2.2
Blood Platelet Count	3.1	35.8	55.8	-7.5	-4.9	-6.1	-5.0
Ovarian Cancer	3.0	3.9	5.8	2.3	1.7	2.4	1.3
Alcohol intake frequency.	2.8	6.5	9.6	-1.6	-3.1	-2.1	-3.1
Prostate Cancer	2.7	3.8	5.8	-1.1	-2.4	-2.4	-1.5
Suffer from ‘nerves’	2.7	4.3	5.2	-2.3	-2.1	-2.1	-1.8
Rheumatoid Arthritis	2.6	3.6	7.2	-2.7	-1.6	-2.0	-0.7
Commuting to job workplace: Car/motor vehicle	2.6	3.0	3.5	-1.7	-1.8	-1.9	-1.5
Medication: Atorvastatin	2.6	3.2	5.0	-2.2	-2.0	-1.7	-1.1
Medication for hormone replacement therapy	2.5	2.8	3.9	1.4	2.0	1.8	1.5
Tinnitus: Yes, now most or all of the time	2.5	2.9	5.2	2.3	1.3	1.6	1.5
Commuting to job workplace: Cycle	2.5	3.0	4.7	0.9	2.2	1.5	2.1
Length of working week for main job	2.4	2.6	3.7	1.5	1.9	1.6	1.4
Heart disease (mother)	2.4	2.9	3.6	-1.9	-1.8	-1.6	-1.4
Hand grip strength (left)	2.3	5.9	11.2	-0.8	-2.3	-2.6	-3.3
Risk taking	2.2	3.2	3.7	1.7	1.9	1.9	1.7
Systolic Blood Pressure	2.1	10.4	12.4	-3.5	-3.0	-3.4	-3.0
Family relationship satisfaction	2.1	2.6	3.6	1.3	1.9	1.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	5.9	0.2	2.4	1.6	1.2
Father’s age at death	2.0	2.7	3.7	-1.6	-1.6	-1.9	-1.4
Birth weight	2.0	4.4	8.4	1.0	2.4	1.6	2.9
Coronary Artery Disease (CAD)	1.9	2.2	2.7	1.4	1.5	1.6	1.4
Schizophrenia (2014)	1.9	4.2	6.1	2.5	1.3	2.3	1.9
Nervous feelings	1.9	3.6	4.3	-1.9	-2.1	-1.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.1	2.7	2.0	2.2	1.2
Medication: Lansoprazole	1.9	2.2	2.8	-1.6	-1.4	-1.1	-1.7
Hand grip strength (right)	1.8	4.9	10.1	-0.7	-1.9	-2.3	-3.2
Hypertension (Self-reported)	1.8	5.1	9.3	-3.0	-2.0	-2.1	-1.6
Bipolar Disorder or Schizophrenia	1.7	4.0	5.5	2.3	1.7	2.3	1.6
Cardiovascular Disease	1.7	5.6	9.5	-3.1	-1.9	-2.2	-2.1
Systolic blood pressure, automated reading	1.7	4.8	6.8	-2.6	-2.1	-2.3	-1.7
Qualifications: CSEs or equivalent	1.7	2.2	2.8	-1.6	-1.2	-1.5	-1.7
Diabetes (self-reported)	1.7	2.6	4.2	1.7	1.4	2.0	1.1
Alcohol drinker status: Previous	1.7	1.9	3.4	1.8	0.8	1.7	0.9
Hearing difficulty/problems: Yes	1.6	2.5	3.6	-1.6	-1.9	-1.7	-0.9
High blood pressure	1.6	4.5	8.1	-2.9	-1.9	-1.9	-1.5
Medication: Allopurinol	1.6	2.2	3.6	1.4	1.0	1.4	1.9
Schizophrenia (2018)	1.5	3.1	5.0	2.2	1.1	1.9	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.5	-1.1	-1.2	-1.0	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.5	-1.0	-1.9	-1.6	-1.6
Hair/balding pattern: Pattern 2	1.4	1.7	3.6	1.9	1.1	1.2	0.8
Illnesses of mother	1.4	1.7	3.3	1.8	1.1	1.2	0.8
Impedance of arm (left)	1.3	5.8	11.0	3.3	1.9	2.1	2.0
Diastolic blood pressure, automated reading	1.3	4.2	9.2	-3.0	-1.3	-2.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.0	1.3	1.1	1.2	1.4
Basal cell carcinoma (self-reported)	1.3	1.6	4.3	2.1	0.6	1.0	0.7
Diabetes (mother)	1.2	1.6	3.2	-1.8	-1.3	-1.2	-0.3
Relative age voice broke	1.2	1.9	4.1	0.7	-2.0	-0.3	-1.6
Medication: Simvastatin	1.2	1.7	2.3	1.4	1.3	1.5	1.1
Exposure to tobacco smoke at home	1.2	1.3	1.6	1.2	0.8	1.2	1.3
Health satisfaction	1.2	1.6	2.3	-1.1	-1.0	-1.3	-1.5
Chest pain or discomfort	1.2	1.7	3.8	0.9	0.6	1.3	1.9
Diabetes diagnosed by doctor	1.2	1.9	3.1	1.4	1.1	1.8	1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	1.6	1.2	1.1	1.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.2	2.3	1.3	1.6	0.7
Hearing difficulty/problems with background noise	1.1	1.8	3.1	-1.8	-1.2	-1.6	-0.6
Birth weight of first child	1.1	2.0	3.5	1.9	1.5	1.4	0.7
Shortness of breath walking on level ground	1.1	1.4	2.0	-1.2	-0.9	-1.1	-1.4
Average weekly red wine intake	1.1	1.6	2.2	1.2	1.5	1.2	1.1
Ever had bowel cancer screening	1.1	1.3	2.8	0.7	0.6	1.2	1.7
Commuting to job workplace: Walk	1.1	1.2	1.4	1.1	1.2	1.1	0.9
Mother’s age at death	1.1	1.4	1.9	1.4	1.0	1.0	1.3
Alcohol drinker status: Never	1.1	1.4	2.7	-0.6	-1.6	-1.1	-1.0
Worry (Nagel 2018)	1.0	2.1	2.5	-1.4	-1.6	-1.3	-1.5
Primary Biliary Cirrhosis	1.0	1.4	1.7	1.0	1.2	1.3	1.2
Waist Hip Ratio (WHR)	1.0	4.3	5.7	2.0	2.2	2.4	1.6
Allergy	1.0	2.4	3.1	1.7	1.5	1.7	1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.7	-1.6	-1.0	-1.2	-0.6
Number of live births	1.0	1.5	2.0	-0.9	-1.2	-1.3	-1.4
Prospective memory result	1.0	1.2	1.5	-1.2	-1.2	-1.0	-1.0
Osteoarthritis (self-reported)	1.0	1.3	2.9	0.9	0.6	1.1	1.7
Unable to work because of sickness or disability	1.0	1.2	3.0	-1.7	-0.2	-1.2	-0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.0	-1.4	-0.9	-1.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.1	0.2	1.5	1.2	0.8
Supplements: Zinc	0.9	1.0	1.6	1.1	0.7	0.9	1.3
Alcohol usually taken with meals	0.9	1.4	2.0	1.4	0.7	1.4	1.2
Medication: Ramipril	0.9	1.1	2.7	-0.5	-1.1	-0.5	-1.7
Impedance of arm (right)	0.9	4.4	7.6	2.8	1.9	1.8	1.8
Time employed in main current job	0.9	1.0	1.5	1.2	0.6	1.1	0.9
Hair/balding pattern: Pattern 4	0.9	2.1	2.3	-1.5	-1.3	-1.5	-1.5
Loud music exposure frequency	0.9	1.0	2.5	0.3	1.6	1.0	0.6
Headache pain in last month	0.9	1.6	4.7	-0.6	-2.2	-0.9	-0.9
Qualifications: College or University degree	0.9	2.7	4.3	1.4	2.1	1.2	1.8
Neck or shoulder pain in last month	0.9	1.2	2.8	-0.4	-1.3	-0.6	-1.7
Overall health rating	0.9	1.9	4.9	-2.2	-1.1	-1.1	-0.6
Had major operations	0.9	1.0	2.3	-1.5	-0.5	-1.0	-0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.6	1.1	1.3	1.1	1.0
Age started oral contraceptive pill	0.9	1.1	3.0	-1.7	-0.6	-0.8	-0.7
Depression (Nagel 2018)	0.8	1.3	2.2	-1.1	-1.2	-0.6	-1.5
Lupus	0.8	1.1	2.8	-0.3	1.7	0.6	1.1
Hypothyroidism (self reported)	0.8	1.8	2.0	1.3	1.4	1.2	1.4
Taking other prescription medications	0.8	1.2	2.4	-1.6	-1.3	-0.9	-0.1
Forced vital capacity (FVC)	0.8	3.2	4.7	-1.7	-1.3	-2.2	-1.9
Fluid intelligence score	0.8	1.6	2.2	1.5	1.2	1.2	1.1
Medication: Paracetamol	0.8	1.4	2.5	0.1	-1.6	-0.9	-1.5
Number of full brothers	0.8	1.0	1.4	-1.2	-0.9	-0.7	-1.2
Medication: Omeprazole	0.8	0.9	2.1	1.4	0.6	1.0	0.5
Bipolar Disorder (2018)	0.7	1.2	1.8	1.0	1.4	1.2	0.7
Fed-up feelings	0.7	1.3	2.1	-1.0	-1.1	-1.0	-1.4
Medication: Cholesterol lowering	0.7	1.1	1.9	1.0	0.9	1.4	0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.9	1.4	1.1	1.2	1.0
Arm fat-free mass (right)	0.7	3.3	3.9	-1.9	-1.7	-2.0	-1.7
Comparative body size at age 10	0.7	1.9	2.2	1.2	1.5	1.3	1.5
Number of children fathered	0.7	0.8	2.0	-0.1	1.4	0.6	1.0
Emphysema/chronic bronchitis	0.7	0.8	1.2	-1.0	-0.5	-1.1	-0.9
Arm predicted mass (right)	0.7	3.7	4.4	-2.1	-1.7	-2.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.7	-0.1	-1.3	-1.6	-1.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	-0.7	-0.5	-1.2	-1.0
Medication: Aspirin	0.7	0.9	1.5	1.2	0.4	1.2	0.7
Illnesses of father: None of the above (group 1)	0.7	0.9	2.1	1.5	1.0	0.6	0.1
Wears glasses or contact lenses	0.7	0.8	1.9	-0.6	-1.4	-0.9	-0.2
Arm fat-free mass (left)	0.7	3.5	4.0	-2.0	-1.7	-2.0	-1.8
Pain experienced in last month	0.7	1.2	1.5	1.2	1.1	1.0	0.9
Arm predicted mass (left)	0.7	3.6	4.7	-2.2	-1.6	-2.1	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	2.1	-1.0	-1.0	-0.7	-1.5
Crohns Disease (2012)	0.6	1.0	1.2	1.1	1.0	1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.8	1.0	1.2	1.3	0.3
Sensitivity / hurt feelings	0.6	1.1	2.8	1.7	-0.3	1.1	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	-0.3	1.0	0.9	1.0
Medication: Atenolol	0.6	0.7	1.7	-0.7	-0.8	-0.4	-1.3
Heart attack	0.6	0.7	1.5	0.9	0.6	1.2	0.4
Illnesses of siblings	0.6	0.8	1.6	0.5	1.3	0.3	1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.3	-1.2	-0.7	-1.7	-1.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	0.7	1.3	0.7	0.4
Loneliness, isolation	0.6	0.8	2.1	1.4	-0.1	1.0	-0.6
Back pain experienced in last month	0.6	0.8	1.2	-1.1	-0.7	-0.9	-0.9
Osteoporosis (self-reported)	0.6	0.8	2.2	0.1	-1.5	-0.7	-0.6
Guilty feelings	0.6	0.9	1.1	1.0	0.7	1.1	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.4	1.9	1.1	1.0	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.4	1.1	0.5	1.2	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.0	1.4	1.1	1.0	1.3
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.3	1.1	1.1	0.7	1.1
Lung FVC	0.5	2.7	3.9	-1.8	-1.0	-2.0	-1.7
Medication: Metformin	0.5	0.7	1.3	-1.2	-0.8	-0.4	-0.8
Age when periods started (menarche)	0.5	1.1	2.5	1.0	0.5	0.9	1.6
Serious illness, injury or assault to yourself	0.5	0.6	1.4	0.5	0.6	0.6	1.2
High blood pressure (mother)	0.5	0.7	1.5	-1.2	-0.3	-0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.5	0.1	-0.0	-0.3	-1.6
Financial difficulties in last 2 years	0.5	0.6	1.7	1.3	0.4	0.7	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.6	0.9	0.8	1.0	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	0.6	0.7	0.8	1.1
High blood pressure (siblings)	0.5	0.7	1.5	-0.3	-1.1	-0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	0.0	1.0	0.3	1.1
Medication: Ibuprofen	0.5	0.6	0.9	-0.7	-0.7	-0.9	-0.7
Mean time to correctly identify matches	0.5	0.9	1.8	-0.3	1.0	0.7	1.4
Pulse rate, automated reading	0.5	1.7	2.8	-1.7	-1.1	-1.6	-0.0
Leg pain on walking	0.5	0.7	1.8	-1.3	-0.2	-0.7	-0.6
Medication: Aspirin	0.5	0.7	1.2	0.9	0.5	1.1	0.6
Smoking status: Previous	0.5	0.8	1.6	0.0	0.9	0.7	1.3
Whole body water mass	0.5	2.7	4.0	-2.0	-1.2	-1.9	-1.4
Medication: Blood pressure	0.5	1.0	2.8	-1.7	-0.5	-0.8	-0.3
Myopia	0.5	0.7	1.1	1.0	0.8	1.0	0.3
Impedance of whole body	0.5	2.6	7.0	2.6	0.8	1.4	0.9
Neuroticism (2016)	0.4	0.6	2.0	-0.2	-1.4	-0.2	-0.3
Respiratory disease	0.4	1.0	1.2	-1.0	-1.1	-1.1	-0.7
Lung FEV1/FVC ratio	0.4	2.2	3.4	1.4	1.9	1.6	1.0
Relative age of first facial hair	0.4	0.9	2.4	1.6	0.1	1.0	0.3
Medication: Co-codamol	0.4	0.5	1.7	-1.3	0.6	0.0	-0.0
Current tobacco smoking	0.4	0.7	1.2	-0.6	-0.7	-1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.9	0.3	-0.8	-0.7
Sitting height	0.4	2.8	5.2	-1.7	-1.4	-2.3	-1.0
Body mass index (BMI)	0.4	1.9	4.8	-2.2	-0.9	-1.0	-1.0
Past tobacco smoking	0.4	0.8	1.5	0.3	-1.1	-0.4	-1.2
Qualifications: None of the above	0.4	0.9	1.8	0.3	1.3	1.1	0.8
Trunk fat-free mass	0.4	2.4	3.7	-1.9	-1.0	-1.8	-1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	-1.2	-0.7	-0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-1.0	-0.4	-0.9	-0.4
Trunk predicted mass	0.4	2.2	3.4	-1.8	-1.0	-1.7	-1.3
Peak expiratory flow (PEF)	0.4	1.0	3.0	-0.4	-0.2	-0.8	-1.7
Medication: Amlodipine	0.4	0.6	1.7	-0.6	-1.3	-0.6	-0.4
Exposure to tobacco smoke outside home	0.4	0.5	1.8	-0.3	-0.2	-0.5	-1.3
Worry too long after embarrassment	0.4	0.7	0.9	1.0	0.6	1.0	0.9
Eye problems/disorders: None of the above	0.4	0.4	1.1	0.4	-0.4	-0.5	-1.0
Comparative height size at age 10	0.4	2.0	2.9	-1.1	-1.1	-1.7	-1.7
Whole body fat-free mass	0.4	2.2	3.5	-1.9	-1.0	-1.7	-1.2
Friendships satisfaction	0.4	0.5	1.6	-0.2	1.3	0.6	0.1
Smoking status: Current	0.4	0.7	1.2	-0.8	-0.6	-1.1	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.1	1.1	0.3	0.8	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.2	0.9	0.6	0.9
Medication: Paracetamol	0.4	0.7	1.6	0.0	-1.3	-0.6	-0.9
Basal metabolic rate	0.4	2.3	3.8	-1.9	-1.0	-1.7	-1.3
Number of operations (self-reported)	0.4	0.5	0.7	-0.9	0.8	0.2	0.8
Supplements: Calcium	0.4	0.4	1.1	1.1	-0.0	0.7	0.2
Number of treatments/medications taken	0.3	0.6	1.4	-0.3	-1.2	-0.2	-1.0
Severe depression (siblings)	0.3	0.3	0.6	-0.3	-0.5	-0.5	-0.8
Impedance of leg (right)	0.3	1.3	4.2	2.0	0.2	1.0	-0.3
Leg fat-free mass (left)	0.3	1.7	3.2	-1.8	-0.7	-1.4	-0.9
Maternal smoking around birth	0.3	0.5	1.6	-1.3	0.1	-0.4	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.1	-0.8	-0.4	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-1.0	-0.3	-0.8	-0.7
Impedance of leg (left)	0.3	1.6	5.2	2.3	-0.0	1.1	-0.0
Leg predicted mass (left)	0.3	1.5	3.0	-1.7	-0.7	-1.4	-0.9
Neuroticism score	0.3	0.6	1.2	-0.6	-1.1	-0.4	-0.8
Weight	0.3	1.7	3.1	-1.8	-0.9	-1.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.7	0.8	0.4	0.8	0.6
Pulse rate	0.3	0.6	1.5	-0.4	0.8	0.3	1.2
Asthma	0.3	0.5	0.8	-0.8	-0.9	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.7	-0.8	0.0	-1.1	-1.3
Breastfed as a baby	0.3	0.3	0.9	-0.1	-1.0	-0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	-0.6	0.6	-0.1	1.1
Forced vital capacity (FVC), Best measure	0.3	1.1	1.8	-0.8	-0.4	-1.3	-1.3
Age at first live birth	0.3	0.6	0.7	0.7	0.8	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	-0.3	-0.5	-0.5	-0.9
Supplements: Vitamin C	0.3	0.4	0.7	0.8	0.5	0.7	0.4
Leg fat-free mass (right)	0.3	1.4	2.6	-1.6	-0.8	-1.4	-0.8
Qualifications: nursing, teaching	0.3	0.5	1.1	0.5	1.1	0.3	0.7
Mineral and other dietary supplements	0.3	0.3	1.0	-1.0	0.2	-0.5	-0.3
Asthma (self-reported)	0.3	0.7	1.2	-0.8	-1.1	-0.6	-0.6
Medication: Gliclazide	0.3	0.4	0.7	-0.4	0.7	0.5	0.9
Leg predicted mass (right)	0.3	1.5	2.8	-1.7	-0.8	-1.4	-0.8
Arm fat mass (left)	0.3	1.0	2.7	-1.6	-0.5	-0.8	-0.8
Ever taken oral contraceptive pill	0.3	0.3	0.9	-0.1	1.0	0.4	0.5
Medication: Bendroflumethiazide	0.3	0.5	1.2	-1.1	-0.6	-0.5	-0.0
Ever smoked	0.3	0.6	1.2	-0.4	1.1	0.1	1.0
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.4	-0.9	-0.2	-0.9
Major Depression (MDD)	0.2	0.2	0.6	-0.5	0.0	-0.8	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	0.3	0.6	0.6	0.6
HbA1C	0.2	0.3	0.9	0.2	-0.3	-0.2	-1.0
Triglycerides	0.2	0.3	0.7	0.5	-0.8	-0.4	0.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.0	0.7	0.4	0.7
Angina	0.2	0.2	0.3	0.6	0.2	0.6	-0.4
Pack years adult smoking proportion	0.2	0.3	0.6	-0.5	-0.5	-0.0	0.8
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.9	0.4	-0.4	0.4
Multivitamins +/- minerals	0.2	0.2	0.6	-0.2	-0.5	-0.8	-0.2
Pain all over the body in last month	0.2	0.2	0.4	0.1	0.7	0.5	-0.4
Hip circumference	0.2	0.8	1.8	-1.4	-0.5	-0.8	-0.5
Alcohol intake versus 10 years previously	0.2	0.4	1.4	-0.1	-0.2	0.0	-1.2
Worrier / anxious feelings	0.2	0.3	0.9	0.9	0.0	0.7	0.0
Happiness	0.2	0.2	0.4	-0.5	-0.1	-0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.0	-0.3	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	0.0	0.9	0.7	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.8	0.2	-0.5	-0.0
Arm fat mass (right)	0.2	0.9	2.8	-1.7	-0.3	-0.7	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.2	-0.2	0.0	1.0
Blood clot in the leg (DVT)	0.2	0.3	0.4	-0.6	-0.4	-0.6	-0.6
Glaucoma (self-reported)	0.2	0.2	0.4	0.1	-0.5	-0.3	-0.6
Gout (self-reported)	0.2	0.2	0.4	0.5	0.4	0.6	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.6	0.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.7	-0.0	0.3	0.6
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	-0.1	0.5	0.1
Medication: Blood pressure	0.2	0.4	0.9	-0.4	-0.8	-0.1	-0.9
Angina (self-reported)	0.2	0.3	0.5	0.7	0.2	0.7	-0.5
Leg fat mass (right)	0.2	0.8	1.9	-1.4	-0.4	-0.4	-1.0
Age at last live birth	0.2	0.2	0.8	0.2	0.0	0.2	0.9
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.3	0.8	0.3	0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.6	-0.1	0.7	-0.2
Mood swings	0.2	0.4	0.9	-0.3	-0.9	-0.2	-0.7
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.8	-0.2	-0.3	-0.6
Financial situation satisfaction	0.2	0.3	0.7	0.9	0.4	0.4	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.2	-0.4	-0.4	-0.8
Average weekly beer plus cider intake	0.2	0.2	0.7	-0.9	0.0	-0.4	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.3	0.4	0.2	0.7
Heart disease (siblings)	0.2	0.2	0.6	-0.8	-0.1	-0.3	-0.4
Pack years of smoking	0.2	0.3	0.7	-0.5	-0.5	0.1	0.9
Leg fat mass (left)	0.2	0.7	1.6	-1.3	-0.5	-0.3	-0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.5	0.7	-0.2	-0.0	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.0
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.1	-0.3	-0.1	-0.6
Reaction Time	0.1	0.2	0.4	-0.1	0.6	0.3	0.3
Breast Cancer	0.1	0.2	0.8	-0.1	0.1	0.3	0.9
Fasting Glucose	0.1	0.1	0.2	-0.2	-0.4	-0.1	0.1
HDL Cholesterol	0.1	0.2	0.4	0.6	-0.0	0.6	-0.4
Ulcerative Colitis	0.1	0.2	0.4	0.1	0.6	0.4	0.6
BMI	0.1	0.6	1.9	-1.4	-0.4	-0.4	-0.5
Neuroticism	0.1	0.3	0.8	-0.3	-0.7	-0.0	-0.9
Chronotype (morning person)	0.1	0.2	0.7	-0.8	-0.1	0.0	0.2
Average weekly spirits intake	0.1	0.1	0.5	0.0	-0.3	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.2	-0.1	0.6	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.4	0.6	0.0	-0.5
Vitamin and mineral supplements	0.1	0.1	0.5	-0.3	0.7	0.1	-0.1
Average weekly fortified wine intake	0.1	0.1	0.3	0.2	-0.6	-0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.3
Waist circumference	0.1	0.2	0.8	-0.9	0.1	0.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	-0.1	0.1	0.1	0.6
Had menopause	0.1	0.2	0.5	-0.0	-0.7	-0.4	-0.3
Mouth/teeth dental problems	0.1	0.1	0.4	0.6	0.0	0.3	-0.2
Arm fat percentage (right)	0.1	0.5	1.3	-1.1	0.6	0.2	0.3
Falls in the last year	0.1	0.1	0.4	-0.4	0.1	-0.0	-0.6
Depression (self-reported)	0.1	0.2	0.4	-0.2	-0.6	-0.2	-0.4
Tense / ‘highly strung’	0.1	0.1	0.4	0.2	0.2	0.2	0.6
Pulse wave reflection index	0.1	0.1	0.3	0.5	0.2	0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.5	-0.0	-0.7	0.5
Leg fat percentage (right)	0.1	0.5	1.3	-1.2	-0.4	-0.0	-0.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.3	-0.4	0.1	0.3
Migraine (self-reported)	0.1	0.2	0.5	0.7	-0.3	0.3	0.0
Medication: Seretide 50 evohaler	0.1	0.2	0.5	-0.7	-0.2	-0.3	0.1
Whole body fat mass	0.1	0.3	1.3	-1.1	-0.1	-0.2	-0.3
Number of full sisters	0.1	0.1	0.4	0.1	-0.6	-0.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.2
Knee pain experienced in last month	0.1	0.2	0.4	-0.7	-0.4	-0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.6	0.2	0.3	0.0
Arm fat percentage (left)	0.1	0.3	1.0	-1.0	0.4	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	0.2	0.4	0.6	0.1
Medication for cholesterol	0.1	0.2	0.4	-0.2	-0.5	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.4	-0.3	-0.5	-0.6
Number of self-reported non-cancer illnesses	0.1	0.3	0.9	-0.1	-1.0	-0.3	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.3	0.5	0.3	0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.1	-0.4	0.5	0.2
Leg fat percentage (left)	0.1	0.4	0.9	-0.9	-0.6	0.1	-0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.5	0.1	0.5
Ever depressed for a whole week	0.1	0.2	0.6	-0.1	-0.2	-0.3	-0.8
Cholesterol lowering medication	0.1	0.2	0.5	-0.1	-0.3	-0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.2	-0.0	-0.2	-0.5
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.3	-0.4	0.1	0.1
Crohns Disease (2017)	0.0	0.1	0.2	-0.3	-0.5	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2
Age at First Birth	0.0	0.0	0.1	0.1	-0.3	0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.1	0.4	0.1	0.1	0.0
Blood Red Count	0.0	0.2	0.2	-0.2	-0.4	0.5	-0.4
Heel T-Score	0.0	0.3	0.6	0.8	0.2	0.8	-0.1
Height	0.0	0.7	1.1	1.1	-0.1	-1.0	-0.9
Smoking Status	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3
Allergy or Eczema	0.0	0.1	0.2	-0.5	0.0	-0.5	-0.1
Hair Pigment	0.0	0.1	0.2	-0.4	0.3	-0.3	-0.4
Tanning	0.0	0.6	1.7	1.3	0.2	0.8	0.1
Trunk fat percentage	0.0	0.0	0.1	-0.2	-0.1	0.3	0.0
Supplements: Glucosamine	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1
Trunk fat mass	0.0	0.2	0.6	-0.8	-0.2	-0.1	-0.3
Noisy workplace	0.0	0.0	0.1	-0.0	-0.1	-0.0	-0.3
Standing height	0.0	0.5	1.0	0.4	-0.5	-1.0	-0.7
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.2	-0.3	-0.0	0.2
Body fat percentage	0.0	0.1	0.3	-0.5	-0.0	0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	0.2	-0.0	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	-0.3	0.1	-0.3	-0.3
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1
Miserableness	0.0	0.0	0.1	-0.1	0.3	0.1	0.2
Medication: Lisinopril	0.0	0.0	0.1	0.3	0.1	-0.1	0.2
Irritability	0.0	0.1	0.2	0.2	-0.0	0.5	0.2

Hub : Genes

LOC90246

Models

Trait associations