Hub : Genes

CNPY3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.134	0.0620	9.3e-03	0.024	NA	0.041	NA	-0.007	4.5e-02	NA	1.3e-02	NA	7.9e-01
2	GTEx	Prostate	0.251	0.1020	9.0e-03	0.011	NA	-0.005	NA	0.023	1.6e-01	NA	4.3e-01	NA	8.8e-02
3	GTEx	Stomach	0.166	0.0600	8.9e-04	0.178	NA	0.126	NA	0.169	6.3e-09	NA	1.3e-06	NA	1.7e-08
4	GTEx	Testis	0.193	0.0680	5.2e-04	0.010	NA	0.031	NA	-0.002	1.2e-01	NA	1.5e-02	NA	3.8e-01
5	TCGA	Prostate Adenocarcinoma	0.160	0.0566	2.6e-11	0.113	0.108	0.109	NA	0.108	7.9e-12	2.5e-11	1.6e-11	NA	2.2e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.0	4.1	2.0	0.2	0.3	-0.9	0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	1.4	1.2	0.7	0.6	-1.2	0.6
Depressed Affect (Nagel 2018)	1.5	3.1	13.4	-3.7	-1.1	-0.7	-0.3	-0.5
Depression (Nagel 2018)	1.3	2.0	3.5	-1.1	1.4	1.4	-1.9	1.2
Intelligence (Savage-Jansen 2018)	1.1	3.3	6.1	0.8	2.2	2.5	-1.4	1.7
Neuroticism (Nagel 2018)	0.8	1.9	8.0	-2.8	0.6	0.6	-0.7	0.6
Schizophrenia (2018)	0.2	0.3	0.7	-0.3	0.8	0.5	-0.7	0.4
Schizophrenia vs Biploar Disorder	1.6	2.1	2.9	-1.1	-1.3	-1.7	1.5	-1.5
Worry (Nagel 2018)	0.7	1.4	2.0	-1.3	1.2	1.4	-0.5	1.3
Alzheimer’s Disease (in mother)	0.9	1.1	2.8	1.7	-0.0	0.5	1.4	0.7
Alzheimer’s Disease (in father)	4.1	4.4	9.2	3.0	2.1	1.6	-2.0	1.4
Alzheimer’s Disease (including proxy)	2.6	3.8	11.6	3.4	1.5	1.4	-0.7	1.6
Crohns Disease (2017)	0.2	0.4	1.5	1.2	-0.4	-0.6	0.1	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.1	-0.4	-0.4	0.7	0.5
Ulcerative Colitis (UC)	0.3	0.6	1.4	-1.1	-0.4	-0.0	1.2	0.5
Major Depression (MDD)	1.1	1.3	2.0	-0.1	1.4	1.4	-1.0	1.2
Reaction Time	0.3	0.7	1.7	1.3	-0.1	-1.0	0.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.3	0.3	1.3	1.8	-1.2	1.1
Breast Cancer	1.1	2.7	4.7	0.8	2.2	1.8	-1.5	1.7
Ovarian Cancer	0.0	0.1	0.1	-0.1	0.4	0.1	-0.1	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	3.0	1.7	-0.0	-1.1	1.1	-1.0
Bipolar Disorder (2011)	1.4	1.4	3.3	1.8	0.6	0.7	-1.5	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-1.4	-1.2	-0.5	0.5	-0.3
Coronary Artery Disease (CAD)	0.6	0.7	2.5	-1.6	0.8	-0.2	-0.2	0.5
Crohns Disease (2012)	0.5	0.8	2.4	1.6	0.6	0.3	-1.1	0.4
Mean Putamen Volume	0.8	0.9	2.5	-0.3	-0.7	-1.1	1.6	-0.7
Fasting Glucose	1.0	1.2	3.1	0.4	0.8	1.1	-1.8	0.8
HbA1C	0.3	0.3	1.2	-1.1	-0.6	0.1	-0.0	-0.3
HDL Cholesterol	5.5	9.2	15.2	2.4	3.9	3.2	-2.5	2.9
LDL Cholesterol	5.4	8.6	14.3	-2.4	-3.8	-2.7	2.8	-2.7
Lupus	0.4	0.5	2.5	-1.6	0.3	-0.2	-0.2	-0.0
Neuroticism (2016)	0.7	1.1	3.2	-1.8	-0.9	-0.8	0.8	-0.1
Primary Biliary Cirrhosis	1.1	1.6	2.8	-1.0	-1.4	-1.2	1.7	-0.7
Rheumatoid Arthritis	0.5	0.7	1.1	0.9	0.3	1.0	-0.7	1.0
Schizophrenia (2014)	0.1	0.2	0.6	0.7	-0.2	-0.6	-0.0	-0.4
Triglycerides	0.2	0.4	1.0	-0.3	-1.0	-0.2	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.3	-0.9	0.6	1.5	-0.9	1.3
Ulcerative Colitis	0.4	0.6	1.2	0.8	0.5	1.0	-0.2	1.1
Blood Eosinophil Count	0.1	0.5	1.4	1.1	-0.1	-0.3	-1.2	-0.0
Blood Platelet Count	1.5	17.9	30.4	1.1	-5.5	-4.3	4.5	-4.5
Blood Red Count	2.4	23.3	37.3	-2.0	-6.0	-6.1	2.7	-5.6
Blood White Count	0.2	1.4	1.7	1.3	-1.2	-1.1	-1.3	-1.0
Heel T-Score	0.4	3.3	15.5	-3.9	0.1	0.1	0.9	0.2
BMI	0.8	4.4	10.8	-0.9	0.5	2.3	-3.3	2.2
Height	0.8	15.3	26.5	4.1	-3.7	-5.2	-1.0	-4.3
Waist Hip Ratio (WHR)	1.1	5.0	14.4	-3.8	1.9	1.1	-0.3	2.4
Systolic Blood Pressure	1.7	8.4	21.6	-4.6	2.1	2.3	-2.1	2.5
Smoking Status	4.0	9.6	12.0	1.8	3.3	3.2	-3.5	3.3
Allergy or Eczema	0.2	0.6	1.0	-0.5	0.8	1.0	-1.0	0.0
Cardiovascular Disease	1.5	5.1	18.8	-4.3	1.1	1.3	-1.1	1.6
Hypothyroidism (self reported)	0.2	0.6	1.9	-0.3	0.6	-0.3	1.4	0.6
Respiratory disease	0.7	1.6	3.5	-1.9	0.6	1.7	-0.5	0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.3	-1.5	-1.3	-0.8	-0.4	-1.1
Lung FEV1/FVC ratio	0.7	3.5	10.4	3.2	0.8	0.6	-2.5	0.0
Lung FVC	0.3	1.3	3.2	1.8	0.1	-1.2	-0.3	-1.4
Neuroticism	0.5	1.1	3.2	-1.8	0.7	0.9	0.4	0.9
Chronotype (morning person)	0.5	1.2	4.2	-2.1	0.2	0.7	-1.0	0.5
Hair Pigment	0.2	5.4	9.2	3.0	2.4	2.4	-1.2	2.2
Tanning	0.1	0.7	2.2	1.5	0.0	0.1	-1.1	0.1
Hand grip strength (left)	0.4	0.9	2.8	1.7	0.8	0.9	-0.2	0.7
Number of treatments/medications taken	1.0	1.7	4.5	-1.1	1.1	1.1	0.8	2.1
Average weekly spirits intake	0.1	0.2	0.5	-0.2	0.1	0.7	-0.3	0.4
Sensitivity / hurt feelings	1.0	1.8	4.1	-0.6	2.0	1.3	0.1	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-1.3	0.8	1.0	0.1	0.8
Hearing difficulty/problems: Yes	2.9	4.4	5.6	1.9	-2.1	-2.1	2.4	-1.9
Relative age of first facial hair	0.7	1.5	3.3	-0.5	-1.0	-0.7	-1.8	-1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-1.1	-0.5	-1.0	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.4	-0.3	-0.7	-1.5	1.5	-0.8
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	-0.5	-0.0	-1.0	-1.3	-0.7
Systolic blood pressure, automated reading	0.5	1.6	3.4	-1.9	0.8	1.2	-1.1	1.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.6	-1.9	-1.5	-1.2	0.8	-0.9
Angina	1.5	2.0	5.8	-2.4	-1.2	-1.5	-0.2	-0.8
Medication for hormone replacement therapy	0.5	0.6	1.4	1.2	0.3	-0.2	1.2	0.0
Vitamin and mineral supplements	2.9	3.9	6.5	-1.4	-2.3	-2.5	0.6	-2.3
Supplements: Zinc	1.5	1.6	3.1	1.8	1.1	1.3	-1.4	0.7
Medication: Co-codamol	0.0	0.0	0.2	-0.1	-0.4	0.0	0.1	-0.0
Medication: Metformin	0.3	0.4	0.8	-0.6	-0.8	-0.9	0.5	-0.5
Diabetes (father)	0.3	0.3	0.6	-0.3	0.7	0.8	-0.0	0.6
Diabetes (mother)	0.2	0.3	0.7	-0.1	-0.1	0.8	-0.8	-0.2
Severe depression (siblings)	0.4	0.4	1.4	-0.7	-0.2	-0.3	1.2	0.2
Pack years adult smoking proportion	1.5	2.3	5.2	-2.3	-1.4	-1.2	1.6	-0.7
Impedance of leg (right)	0.3	1.5	4.1	0.4	-0.2	-1.2	2.0	-1.3
Leg fat-free mass (left)	0.4	2.1	7.8	1.4	-0.7	-0.2	-2.8	0.4
Trunk fat percentage	0.3	1.2	3.5	-0.1	-1.6	-0.0	-1.9	-0.1
Hand grip strength (right)	0.2	0.6	1.7	1.3	-0.6	-0.7	-0.0	-0.7
Townsend deprivation index at recruitment	0.9	1.3	2.8	1.0	0.9	1.3	0.2	1.7
Current tobacco smoking	1.6	2.7	4.3	0.6	1.8	2.0	-1.3	2.1
Average weekly fortified wine intake	1.1	1.3	2.0	1.1	1.3	1.4	-1.0	0.9
Maternal smoking around birth	0.4	0.6	1.1	-1.0	-0.9	-0.5	0.7	0.1
Fed-up feelings	1.0	1.9	8.6	-2.9	-0.7	-0.3	0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	-0.4	0.7	0.9	-1.5	0.6
Relative age voice broke	0.2	0.3	1.0	-0.4	0.4	0.5	-1.0	0.2
Taking other prescription medications	1.5	2.3	3.6	-0.9	1.1	1.7	-1.7	1.9
Age when periods started (menarche)	1.6	3.9	8.0	1.4	-1.9	-1.8	1.6	-2.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.2	-0.2	-0.8	-1.8	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	-1.8	-1.1	-0.4	0.8	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	-0.5	-0.7	-0.6	-0.4	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.2	0.8	0.9	1.1	-0.7	0.8
Serious illness, injury or assault to yourself	1.1	1.4	2.3	0.7	0.8	1.5	-1.1	1.5
High blood pressure	1.3	3.6	16.5	-4.1	0.6	0.8	-0.7	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	0.1	1.0	1.1	-1.2	0.1
Multivitamins +/- minerals	1.8	2.3	3.0	1.7	1.6	1.7	-0.6	1.6
Stomach or abdominal pain in last month	1.8	2.3	6.9	-2.6	-0.9	-0.3	1.9	0.4
Supplements: Glucosamine	1.0	1.3	2.3	1.2	0.8	1.5	0.2	1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-1.3	-0.8	-0.7	0.2	-0.5
Medication: Atenolol	0.8	1.0	4.2	-2.1	0.1	-0.1	-0.8	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.3	0.3	-0.4	0.3	-0.4
Sitting height	0.4	3.0	6.8	1.1	-1.9	-2.6	-0.5	-1.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	-0.3	-0.6	-0.5	0.4	-0.9
High blood pressure (mother)	2.1	3.0	7.9	-2.8	1.2	1.1	0.8	1.9
Body mass index (BMI)	0.4	1.9	6.6	-0.3	-0.5	1.1	-2.6	1.2
Impedance of leg (left)	0.3	1.3	3.7	0.1	-0.2	-1.2	1.9	-1.2
Leg predicted mass (left)	0.4	2.1	7.7	1.4	-0.7	-0.3	-2.8	0.3
Trunk fat mass	0.4	1.8	5.1	0.5	-1.9	-0.4	-2.3	-0.3
Waist circumference	0.4	1.5	4.4	-0.2	-0.2	0.9	-2.1	1.5
Number of incorrect matches in round	0.4	0.7	1.8	1.3	0.1	0.0	1.2	0.2
Past tobacco smoking	2.0	3.6	6.8	-0.8	-2.0	-1.6	2.6	-2.0
Alcohol usually taken with meals	0.7	1.2	2.4	1.4	1.6	0.8	-0.5	0.8
Nervous feelings	0.2	0.3	0.4	-0.2	0.7	0.6	0.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-1.5	-0.5	-0.4	1.3	-0.5
Hearing difficulty/problems with background noise	2.1	3.3	5.0	2.2	-1.5	-1.8	1.7	-1.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.2	-0.1	-0.6	-0.9	-0.8
Had menopause	0.3	0.4	1.1	0.2	0.0	-0.8	1.0	-0.3
Had other major operations	0.4	0.5	1.3	-0.9	0.4	0.5	-1.1	0.3
Forced vital capacity (FVC)	0.5	1.8	7.0	2.6	-0.0	-0.9	-0.3	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.3	-2.3	-1.8	-1.1	1.5	-1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.6	0.7	0.8	-1.0	0.7
Qualifications: None of the above	1.8	3.9	6.5	-1.5	-2.5	-2.1	1.9	-1.6
Financial difficulties in last 2 years	0.1	0.2	0.2	-0.4	-0.5	-0.2	0.4	0.5
Mouth/teeth dental problems	0.8	1.3	4.0	0.9	0.4	-0.2	-2.0	-1.1
Heart attack	0.6	0.8	1.5	-1.2	-0.7	-1.2	-0.3	-0.8
Allergy	0.2	0.5	1.5	1.2	-0.2	-0.5	0.7	0.3
Pain all over the body in last month	1.1	1.1	2.7	-1.6	-0.9	-0.6	1.2	-0.6
Diabetes (self-reported)	2.0	3.2	4.7	-1.9	-2.2	-1.8	1.1	-1.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	0.1	0.1	1.2	-0.5	0.4
Medication: Ramipril	0.4	0.5	1.6	-0.2	0.6	0.6	-1.3	0.3
Medication: Simvastatin	1.3	1.9	3.1	-1.8	-1.3	-1.4	1.6	-0.5
Fluid intelligence score	0.2	0.5	1.4	-1.2	0.4	0.2	1.0	0.1
Illnesses of siblings	1.7	2.4	7.0	2.6	1.0	-0.1	-1.7	-1.0
Neuroticism score	0.8	1.7	2.3	-1.5	1.4	1.4	-0.6	1.4
Weight	0.4	1.9	6.2	1.1	-1.4	-0.4	-2.5	0.2
Impedance of arm (right)	0.1	0.5	1.2	0.4	-0.2	-0.2	1.0	-1.1
Arm fat percentage (right)	0.4	1.4	4.7	-0.4	-1.4	0.7	-2.2	0.3
Trunk fat-free mass	0.5	2.8	3.8	1.6	-1.7	-1.9	-2.0	-1.0
Hip circumference	0.7	3.0	7.8	2.4	-1.1	-0.0	-2.8	-0.1
Time employed in main current job	0.6	0.6	2.7	1.6	-0.4	-0.0	0.6	0.1
Alcohol intake versus 10 years previously	0.3	0.4	1.4	-0.6	0.3	0.6	-1.2	-0.1
Father’s age at death	1.2	1.6	5.2	2.3	1.0	0.5	1.2	0.0
Worrier / anxious feelings	1.0	1.8	5.0	-2.2	1.1	1.3	0.0	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.7	-0.6	-0.0	-0.0	-0.4
Falls in the last year	10.1	13.6	22.9	1.0	4.2	4.5	-2.5	4.8
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-0.7	0.2	-0.5	1.2	-0.5
Number of live births	0.8	1.1	2.0	0.2	-1.2	-1.4	0.6	-1.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.9	12.0	3.5	0.5	-0.4	-1.2	-0.5
Pulse rate	2.9	4.9	6.4	2.3	2.5	2.3	-2.1	1.8
Happiness	0.4	0.4	1.2	-1.1	0.3	0.1	0.9	0.4
Noisy workplace	0.3	0.3	1.4	-0.2	0.0	-0.1	1.2	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.5	0.7	1.6	1.4	-0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	4.4	5.1	8.2	-1.2	-2.9	-2.1	2.5	-2.2
Mouth/teeth dental problems: Dentures	0.5	0.8	2.7	-0.2	0.4	1.0	-0.2	1.6
Asthma	0.5	0.9	3.5	-1.9	-0.8	-0.0	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.2	1.1	-0.1	-0.1	-0.2	-0.2
Medication: Cholesterol lowering	3.4	5.2	8.2	-1.9	-2.7	-2.9	1.7	-2.1
Depression (self-reported)	3.0	3.6	5.8	0.5	2.2	2.4	-1.4	2.3
Medication: Lansoprazole	0.2	0.3	0.9	-0.9	-0.4	0.0	0.3	0.3
Prospective memory result	0.4	0.5	1.1	1.1	-0.4	-0.6	-0.9	-0.1
Lung cancer (father)	1.1	1.3	3.0	-1.7	-0.9	-1.4	0.5	-0.7
Illnesses of mother	1.6	2.0	3.5	0.7	-1.5	-1.9	-0.1	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	8.7	3.0	-0.2	-1.1	-1.5	-1.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.3	-0.3	-0.1	-0.9	0.2
Impedance of arm (left)	0.2	0.7	2.3	0.0	-0.2	-0.2	1.5	-1.1
Arm fat mass (right)	0.4	1.8	6.8	0.2	-1.3	0.3	-2.6	0.4
Trunk predicted mass	0.5	2.8	3.9	1.5	-1.7	-1.9	-2.0	-1.0
Standing height	0.6	6.2	11.0	3.1	-2.2	-3.3	-0.1	-2.4
Length of working week for main job	0.2	0.2	0.7	-0.3	0.2	0.0	-0.8	0.0
Exposure to tobacco smoke at home	2.4	2.7	4.1	1.3	1.9	2.0	-0.2	2.0
Breastfed as a baby	0.4	0.5	1.0	1.0	0.4	0.2	-0.9	-0.4
Tense / ‘highly strung’	0.7	1.2	1.7	0.4	1.3	1.2	-1.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.5	-0.1	1.4	1.6	-1.2	1.6
Hair/balding pattern: Pattern 4	1.3	3.0	4.5	2.1	1.2	1.4	-2.1	1.7
Birth weight of first child	0.5	0.9	3.1	-0.8	-1.8	-0.5	-0.1	-0.5
Peak expiratory flow (PEF)	0.3	0.6	1.7	1.3	-0.1	-0.5	-0.9	-0.6
Pulse wave reflection index	3.6	4.5	7.4	-1.0	-2.7	-2.7	1.3	-2.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.8	-1.7	-1.2	-0.6	1.1	-0.6
Loud music exposure frequency	0.6	0.6	2.7	0.2	-0.1	-0.5	1.6	-0.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.1	0.9	1.8	1.7	-0.4	1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.9	-0.3	-0.6	-0.7	1.7	-0.2
Blood clot in the leg (DVT)	0.2	0.3	0.9	-1.0	0.4	0.0	-0.3	0.5
Medication: Paracetamol	2.0	3.3	6.1	0.5	1.9	2.2	-1.3	2.5
Headache pain in last month	0.2	0.4	2.0	-1.4	0.1	-0.2	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.1	1.5	1.2	1.4	-0.8	1.0
Glaucoma (self-reported)	1.1	1.3	2.9	-0.6	-0.6	-1.3	1.7	-1.1
Gout (self-reported)	1.9	2.6	5.4	-0.4	1.4	2.3	-1.3	1.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.7	-0.0	0.5	-0.4	1.3	0.3
Medication: Amlodipine	1.8	2.5	11.9	-3.5	-0.2	-0.4	-0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	0.5	0.3	-0.4	-0.1
Birth weight	2.2	4.9	7.8	2.3	2.0	2.0	-2.8	1.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.4	-1.6	-0.6	-0.1	1.1	0.4
High blood pressure (siblings)	1.5	2.1	7.2	-2.7	-0.2	0.1	1.5	1.0
Forced vital capacity (FVC), Best measure	0.5	1.9	4.7	2.2	-0.5	-1.2	-0.8	-1.6
Body fat percentage	0.2	1.0	2.9	-0.1	-1.4	0.2	-1.7	0.3
Leg fat percentage (right)	0.2	0.6	1.7	-0.0	-1.0	0.4	-1.3	0.5
Arm fat-free mass (right)	0.4	1.9	3.1	1.1	-1.5	-1.6	-1.8	-0.5
Exposure to tobacco smoke outside home	1.4	1.8	3.5	0.5	1.7	1.6	0.1	1.9
Comparative body size at age 10	2.6	7.2	13.5	-0.6	3.2	3.4	-0.6	3.7
Number of full brothers	0.5	0.6	2.4	0.1	-0.6	0.2	1.5	0.6
Worry too long after embarrassment	0.5	0.8	2.0	-1.0	1.0	0.3	-1.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.4	-1.6	-0.5	-0.6	-0.4	-0.1
Wheeze or whistling in the chest in last year	1.2	2.1	3.4	-1.9	1.1	1.5	-0.6	1.8
Number of children fathered	0.5	0.6	1.0	-0.4	-1.0	-1.0	-0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.7	-0.4	0.7	0.5	0.9	0.7
Age at first live birth	0.6	1.1	4.1	2.0	0.3	0.5	-0.9	-0.4
Pulse wave peak to peak time	0.2	0.2	0.8	-0.2	0.1	-0.1	0.9	-0.3
Health satisfaction	0.6	0.8	2.2	-0.5	-1.1	-0.7	1.5	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.3	-0.3	0.5	0.6	1.1	0.6
Qualifications: College or University degree	1.3	4.0	8.9	1.6	2.2	1.8	-3.0	0.6
Eye problems/disorders: None of the above	2.1	2.5	3.7	1.6	1.8	1.9	-1.1	1.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.9	0.1	-0.1	-0.7	1.4	-0.3
Emphysema/chronic bronchitis	0.5	0.6	0.8	-0.8	0.9	0.8	0.4	0.8
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	-0.2	-1.0	-0.7	0.7	-1.3
Neck or shoulder pain in last month	1.5	2.2	7.0	-2.6	-1.2	-1.0	1.1	-0.5
Medication: Blood pressure	0.4	0.8	2.9	-1.7	0.2	0.3	-0.8	0.2
Angina (self-reported)	1.4	1.8	5.3	-2.3	-1.1	-1.4	-0.2	-0.8
Migraine (self-reported)	0.2	0.3	0.7	0.6	0.2	0.5	0.8	0.2
Medication: Ibuprofen	0.6	0.7	1.8	1.3	0.6	0.7	-0.7	0.6
Medication: Allopurinol	0.4	0.5	1.6	-1.3	-0.1	0.9	0.1	0.6
Medication: Omeprazole	2.4	2.9	5.4	1.3	2.3	1.7	0.1	2.1
Medication: Seretide 50 evohaler	0.4	0.4	1.6	-1.3	0.2	-0.1	0.6	0.4
Mean time to correctly identify matches	0.6	1.1	2.2	1.5	-0.3	-1.4	0.3	-1.2
Heart disease (mother)	0.1	0.1	0.5	-0.7	-0.2	0.1	0.2	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	8.2	9.7	14.2	2.1	3.6	3.8	-2.5	3.3
Whole body fat mass	0.3	1.4	3.9	0.5	-1.6	-0.2	-2.0	-0.0
Leg fat mass (right)	0.3	1.2	4.6	0.5	-1.0	0.2	-2.1	0.5
Arm predicted mass (right)	0.4	1.9	3.3	1.0	-1.6	-1.6	-1.8	-0.4
Pulse rate, automated reading	2.5	8.1	11.6	3.0	2.9	3.4	-1.6	3.1
Alcohol intake frequency.	0.6	1.5	5.4	-2.3	-0.6	-0.7	-0.5	-0.9
Comparative height size at age 10	0.4	2.5	6.2	0.9	-1.9	-2.5	-0.7	-1.1
Number of full sisters	1.3	1.6	3.0	1.7	0.7	1.4	-1.3	1.0
Suffer from ‘nerves’	3.9	6.2	10.1	1.3	2.7	3.2	-1.4	3.2
Overall health rating	0.3	0.6	1.3	-1.1	-0.6	-0.7	0.8	-0.2
Chest pain or discomfort	1.4	2.0	7.6	-2.8	-0.9	-0.3	1.1	0.0
Had major operations	0.9	1.0	4.3	-2.1	-0.4	-0.5	-0.5	-0.3
Age at last live birth	1.8	2.7	11.0	3.3	0.6	0.7	-1.2	-0.1
Family relationship satisfaction	1.8	2.2	4.0	-0.0	1.3	2.0	-1.3	1.9
Leg pain on walking	0.7	0.9	1.6	-1.2	-1.1	-0.7	1.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.5	0.6	1.6	1.4	-1.1	1.6
Commuting to job workplace: Car/motor vehicle	2.5	2.9	5.8	-1.5	-2.4	-1.6	1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	0.9	1.3	1.2	-0.2	0.9
Medication: Aspirin	2.1	2.7	7.0	-2.6	-1.0	-2.0	0.4	-1.2
Supplements: Vitamin C	2.2	2.6	3.6	1.6	1.9	1.9	-0.8	1.6
Knee pain experienced in last month	0.2	0.3	0.9	-0.8	0.3	0.0	0.1	0.9
Hypertension (Self-reported)	1.5	4.1	20.3	-4.5	0.2	0.3	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.5	0.1	0.1	-0.3	0.3
Illnesses of father: Heart disease	0.3	0.4	1.6	-1.2	-0.2	-0.4	0.2	0.1
Illnesses of siblings: Diabetes	1.0	1.2	3.7	-1.9	-1.2	0.1	1.0	0.3
Smoking status: Previous	1.6	2.4	7.7	0.5	1.2	0.9	-2.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	5.4	1.2	0.3	0.3	-2.3	0.1
Whole body fat-free mass	0.4	2.2	5.6	1.4	-1.3	-1.3	-2.4	-0.4
Leg fat-free mass (right)	0.4	2.0	7.8	1.3	-0.6	-0.3	-2.8	0.3
Arm fat percentage (left)	0.3	1.3	4.1	-0.5	-1.3	0.7	-2.0	0.4
Average weekly red wine intake	0.4	0.6	0.9	0.7	0.6	0.7	0.8	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	0.7	-0.5	-0.1	0.2	0.2
Mood swings	0.6	1.1	2.8	-1.7	0.9	0.8	-0.3	1.0
Loneliness, isolation	0.4	0.5	1.7	-1.3	-0.4	-0.3	-0.8	0.0
Long-standing illness, disability or infirmity	0.5	0.7	1.2	0.7	1.1	0.7	0.5	1.0
Ever had bowel cancer screening	0.2	0.2	0.7	-0.8	-0.3	-0.4	0.0	0.1
Diabetes diagnosed by doctor	0.6	1.0	1.3	-1.1	-1.1	-1.0	0.3	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	4.4	4.7	11.0	0.0	1.9	2.1	-3.3	2.1
Friendships satisfaction	0.4	0.5	1.0	-0.5	0.5	0.8	-0.4	1.0
Qualifications: nursing, teaching	0.1	0.2	0.9	0.3	0.1	0.1	-1.0	-0.2
Commuting to job workplace: Walk	1.8	1.9	3.5	1.1	1.9	1.5	-0.8	1.4
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.2	-0.5	-0.2	-0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.0	-0.3	-0.7	-0.6	1.7	-0.2
Medication for cholesterol	1.0	1.6	4.8	2.2	-0.7	-0.6	-0.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.6	-1.9	1.1	1.3	-1.1	1.5
Back pain experienced in last month	1.7	2.5	5.5	-2.0	1.1	1.3	-0.2	2.3
Mineral and other dietary supplements	3.4	4.5	6.8	-2.6	-2.1	-2.3	-0.7	-2.4
Breast cancer (self-reported)	1.7	2.0	3.1	-0.3	1.8	1.6	-1.0	1.8
Asthma (self-reported)	0.4	0.7	2.9	-1.7	-0.6	0.3	-0.3	-0.4
Osteoporosis (self-reported)	0.8	1.0	2.5	-0.5	-1.2	-0.7	1.6	-0.5
Osteoarthritis (self-reported)	1.4	1.8	2.7	1.6	0.9	1.6	-1.0	1.4
Medication: Aspirin	1.6	2.1	5.7	-2.4	-0.7	-1.8	0.0	-1.0
Medication: Gliclazide	0.9	1.0	2.5	-1.6	-1.0	-0.6	1.1	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.5	0.6	-0.6	-0.5	1.6	-0.2
Smoking status: Current	2.5	3.9	5.3	1.0	2.3	2.3	-1.8	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.6	1.9	0.1	-0.3	-0.6	-0.9
Whole body water mass	0.4	2.2	5.4	1.3	-1.4	-1.3	-2.3	-0.5
Leg predicted mass (right)	0.4	2.1	8.0	1.4	-0.6	-0.3	-2.8	0.4
Arm fat mass (left)	0.4	1.6	5.2	0.1	-1.7	-0.1	-2.3	0.1
Number of self-reported non-cancer illnesses	1.4	2.4	4.3	-1.4	1.2	1.9	-0.7	2.1
Average weekly champagne plus white wine intake	2.2	3.0	4.7	2.2	1.5	1.6	-2.2	0.8
Miserableness	1.0	1.8	6.4	-2.5	-1.2	-0.5	0.5	-0.8
Guilty feelings	0.4	0.5	2.6	-1.6	0.3	-0.0	-0.1	-0.2
Wears glasses or contact lenses	0.3	0.3	1.0	-0.4	-0.4	-0.3	1.0	-0.2
Ever taken oral contraceptive pill	0.8	0.8	2.6	0.2	-0.2	-0.7	-1.0	-1.6
Hearing aid user	0.2	0.2	0.5	0.7	-0.1	-0.1	0.6	0.5
Mother’s age at death	1.0	1.3	3.8	1.9	0.8	0.8	0.8	0.8
Financial situation satisfaction	0.3	0.3	0.8	0.7	0.6	0.9	-0.1	0.4
Tinnitus: Yes, now most or all of the time	1.6	1.9	6.4	2.5	0.6	1.0	-1.2	0.5
Commuting to job workplace: Public transport	0.3	0.3	1.1	0.2	0.1	-0.3	-1.1	-0.6
Eye problems/disorders: Glaucoma	2.0	2.4	3.5	-1.5	-1.0	-1.9	1.9	-1.4
Medication: Blood pressure	1.4	2.8	12.6	-3.6	0.1	0.6	0.1	0.8
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	0.2	-0.5	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	4.1	5.3	9.7	1.8	2.5	2.7	0.1	3.1
High cholesterol (Self-reported)	0.9	1.6	5.5	-2.4	-0.5	-0.8	1.1	0.4
Medication: Bendroflumethiazide	1.3	2.0	4.8	-2.2	0.7	1.3	-1.3	1.2
Medication: Paracetamol	1.5	2.3	5.0	-0.2	1.6	1.7	-0.8	2.2
Medication: Lisinopril	0.7	0.9	3.7	-1.9	0.5	0.5	-0.2	0.2
Medication: Atorvastatin	1.2	1.5	5.9	-2.4	-0.9	-0.7	0.4	-0.4
Illnesses of father: High blood pressure	0.7	0.9	1.4	-0.8	1.2	0.8	-0.6	1.1
Alcohol drinker status: Never	0.7	0.8	2.0	-0.9	-1.4	-0.4	0.1	-1.0
Ever smoked	1.5	2.7	4.2	1.6	2.1	1.2	-1.8	1.5
Basal metabolic rate	0.4	2.3	6.3	1.4	-1.4	-1.1	-2.5	-0.2
Leg fat percentage (left)	0.2	0.9	2.8	-0.1	-0.9	0.5	-1.7	0.7
Arm fat-free mass (left)	0.4	2.2	5.1	1.3	-1.4	-1.5	-2.3	-0.3
Number of operations (self-reported)	0.3	0.5	1.5	-1.2	-0.1	-0.0	-0.9	0.4
Average weekly beer plus cider intake	0.8	1.2	2.0	-0.3	-1.4	-1.3	0.7	-1.3
Irritability	0.8	1.4	3.2	0.1	1.4	1.8	0.1	1.4
Risk taking	3.1	4.5	8.4	0.6	2.9	2.0	-1.2	2.9
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	-1.2	-1.1	-0.8	1.0	-0.9
Fractured/broken bones in last 5 years	0.5	0.6	1.2	0.8	0.5	1.1	-0.8	0.6
Age started oral contraceptive pill	1.4	1.7	3.3	0.5	-1.1	-1.8	0.8	-1.8
Diastolic blood pressure, automated reading	0.2	0.7	1.9	-1.1	-0.2	0.5	-1.4	0.1
Ever depressed for a whole week	0.6	0.8	1.5	-1.2	0.5	0.6	0.6	1.2
Unable to work because of sickness or disability	1.0	1.3	2.7	-0.1	1.4	1.0	0.8	1.6
Commuting to job workplace: Cycle	1.6	2.0	4.0	0.5	1.9	1.3	-0.6	2.0
Myopia	0.7	1.0	1.8	-1.2	0.8	1.1	0.2	1.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	18.1	4.3	-0.4	-0.7	0.9	-0.7
Cholesterol lowering medication	0.9	1.3	3.1	-1.8	0.5	0.6	0.7	1.5
Medication: Omeprazole (e.g. Zanprol)	3.1	3.7	6.3	1.9	2.5	1.9	-0.5	2.2
Pain experienced in last month	2.0	3.3	9.8	3.1	1.6	1.5	-1.1	0.9
Supplements: Calcium	0.2	0.3	0.6	0.3	0.8	0.6	0.1	0.5
Basal cell carcinoma (self-reported)	1.6	2.0	3.1	-1.1	-1.7	-1.6	0.1	-1.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-1.0	-0.4	-1.0	-0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	-1.1	0.1	-0.3	0.3	0.3
Heart disease (siblings)	1.2	1.5	3.1	-1.8	-1.7	-0.8	0.3	-0.6
Alcohol drinker status: Previous	2.7	3.1	4.7	0.1	2.2	2.2	-1.7	1.8
Pack years of smoking	1.6	2.3	4.1	-2.0	-1.3	-1.3	1.9	-0.7
Impedance of whole body	0.3	1.3	3.8	0.2	-0.4	-0.8	1.9	-1.4
Leg fat mass (left)	0.4	1.4	5.5	0.4	-0.9	0.2	-2.4	0.7
Arm predicted mass (left)	0.4	2.3	5.4	1.2	-1.5	-1.5	-2.3	-0.4