TWAS hub - VIPR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.656	0.0430	0.0e+00	0.313	0.329	0.363	0.365	0.368	7.3e-39	4.4e-41	3.3e-46	1.4e-46	5.6e-47
2	GTEx	Adipose Visceral Omentum	0.275	0.0860	6.1e-04	0.097	NA	0.002	NA	0.079	9.6e-06	NA	2.6e-01	NA	6.8e-05
3	GTEx	Artery Aorta	0.119	0.0460	1.4e-03	0.013	NA	0.057	NA	0.027	6.1e-02	NA	4.5e-04	NA	1.2e-02
4	GTEx	Artery Tibial	0.115	0.0524	1.6e-03	0.068	NA	0.043	NA	0.039	5.4e-06	NA	2.4e-04	NA	4.6e-04
5	GTEx	Brain Cerebellum	0.269	0.1050	4.4e-03	-0.007	NA	0.038	NA	0.002	5.7e-01	NA	2.9e-02	NA	2.9e-01
6	GTEx	Brain Cortex	0.349	0.0970	5.4e-04	0.217	NA	0.127	NA	0.179	1.2e-06	NA	2.4e-04	NA	1.1e-05
7	GTEx	Brain Frontal Cortex BA9	0.248	0.1055	5.7e-03	0.016	NA	0.054	NA	0.074	1.2e-01	NA	1.5e-02	NA	5.3e-03
8	GTEx	Breast Mammary Tissue	0.108	0.0470	7.0e-03	0.004	NA	0.002	NA	-0.002	1.8e-01	NA	2.3e-01	NA	4.5e-01
9	GTEx	Breast Mammary Tissue (Male)	0.263	0.1076	2.1e-02	-0.001	NA	-0.012	NA	-0.013	3.5e-01	NA	7.5e-01	NA	9.4e-01
10	GTEx	Breast Mammary Tissue (Female)	0.122	0.0646	3.7e-02	0.009	NA	-0.003	NA	0.002	1.7e-01	NA	4.0e-01	NA	2.8e-01
11	GTEx	Pancreas	0.407	0.0740	7.7e-11	0.381	NA	0.398	NA	0.405	4.1e-17	NA	5.0e-18	NA	2.1e-18
12	ROSMAP	Brain Pre-frontal Cortex	0.501	0.0658	0.0e+00	0.085	0.183	0.222	0.231	0.219	4.5e-11	6.0e-23	4.2e-28	2.9e-29	1.2e-27

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	9	10	11	12
Bipolar Disorder (2011)	5.3	5.1	9.5	-3.1	2.6	-1.4	0.3	-0.9	-2.8	-3.0	-1.8	2.7	-3.1	-2.6
Guilty feelings	4.1	6.2	20.8	-4.6	0.7	-1.6	-1.1	-1.1	-4.4	-3.4	-0.9	0.1	-1.8	-3.8
Worry (Nagel 2018)	3.8	7.9	23.4	-4.4	-0.7	-0.5	2.3	1.6	-4.8	-4.6	-2.0	0.6	-1.4	-4.0
Maternal smoking around birth	3.8	5.5	13.5	3.4	0.1	2.0	-1.1	1.3	2.6	3.1	2.1	-0.1	3.7	3.6
Myopia	3.6	5.3	12.2	3.3	0.7	-1.1	-2.2	1.3	2.8	2.8	3.3	1.1	2.1	3.5
Diabetes (mother)	3.3	4.2	9.8	2.9	-2.0	0.5	-1.5	-1.4	2.9	3.1	2.1	-1.3	1.3	2.8
Neuroticism (Nagel 2018)	3.2	7.4	20.8	-4.5	-0.1	-2.0	0.9	0.0	-4.6	-4.4	-1.5	0.4	-1.9	-4.1
Neuroticism	3.2	7.8	23.2	-4.7	-0.5	-0.9	1.1	-0.2	-4.8	-4.3	-1.8	-0.4	-1.8	-4.5
Back pain experienced in last month	3.1	4.5	9.3	3.0	-1.8	0.6	-2.1	1.2	2.8	2.8	-1.8	0.7	2.4	3.0
Bipolar Disorder (2018)	3.0	4.8	13.5	-3.7	0.3	-0.6	0.5	-1.2	-3.6	-3.0	-1.1	0.0	-2.3	-3.6
Nervous feelings	2.8	5.2	12.3	-3.4	0.9	0.2	2.3	1.3	-3.3	-3.5	-2.3	2.2	-0.8	-2.9
Neuroticism score	2.6	5.5	19.2	-3.9	-0.4	-0.4	0.7	0.2	-4.4	-3.8	-1.4	-0.5	-0.9	-3.7
Schizophrenia vs Biploar Disorder	2.5	3.3	9.1	2.6	0.5	1.4	-1.2	0.5	2.6	3.0	1.2	-0.2	2.4	2.5
Medication: Bendroflumethiazide	2.5	3.7	10.6	3.3	0.7	1.0	1.9	1.0	2.6	2.6	0.6	1.5	1.4	3.2
Number of full sisters	2.4	2.9	8.2	1.9	-2.5	2.2	1.7	0.8	2.0	1.5	-0.1	-2.9	1.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	6.4	2.5	-2.3	0.7	-0.7	1.2	1.9	1.7	1.2	-1.3	1.9	2.5
Tense / ‘highly strung’	2.2	3.7	14.4	-3.4	1.2	-0.4	0.8	0.8	-3.8	-2.9	0.5	0.7	-0.1	-2.5
Commuting to job workplace: Walk	2.2	2.4	10.4	1.2	-2.9	0.7	1.4	1.2	1.2	1.1	-0.6	-3.2	0.9	1.1
Supplements: Zinc	2.1	2.3	6.5	2.1	0.1	-0.1	-0.5	-1.7	2.0	2.6	2.4	0.5	0.9	1.4
Depressed Affect (Nagel 2018)	2.0	4.1	10.1	-3.1	-0.5	-2.6	-1.1	-1.4	-2.8	-3.2	0.1	-0.5	-2.1	-2.8
Prospective memory result	2.0	2.4	8.9	-1.6	3.0	0.3	1.3	0.2	-1.4	-1.5	-1.3	2.9	-1.0	-0.8
Chronic bronchitis/emphysema (mother)	2.0	2.4	7.8	2.7	0.1	-1.3	-1.3	-0.7	2.8	2.4	1.3	-0.2	0.1	1.6
Leg fat percentage (left)	2.0	7.2	20.1	4.5	-0.7	0.0	-1.5	1.2	4.5	3.8	0.2	1.3	2.9	4.1
Fasting Glucose	1.9	2.3	16.1	-0.7	0.1	1.5	-2.3	-0.6	-0.8	-0.7	4.0	1.1	0.0	-1.0
Cardiovascular Disease	1.9	6.4	13.5	3.7	-1.4	1.5	-1.1	0.2	2.7	3.5	3.6	-1.2	3.2	3.7
Illnesses of mother	1.8	2.2	4.6	-1.7	1.6	-0.4	2.1	-0.3	-1.2	-2.0	-1.2	0.6	-2.1	-2.0
Leg fat percentage (right)	1.8	6.4	18.5	4.3	-0.7	0.1	-0.9	0.9	4.3	3.7	0.5	1.2	2.8	3.9
Commuting to job workplace: Cycle	1.8	2.2	7.7	1.7	-0.7	1.3	-2.8	-0.8	1.2	1.7	1.9	-0.7	1.7	1.3
Pulse wave peak to peak time	1.7	2.0	4.6	-1.9	-1.6	-0.1	0.9	-0.8	-1.5	-1.8	-0.5	-2.1	-1.8	-1.6
Mood swings	1.7	3.2	6.4	-2.5	-1.5	-2.0	-1.7	-1.9	-2.3	-2.5	0.5	-0.6	-1.3	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.4	1.5	1.2	0.5	-2.3	-1.6	1.6	2.2	-0.6	-0.2	1.2	1.1
Medication: Atorvastatin	1.7	2.1	5.0	1.4	-1.8	2.2	1.0	2.0	0.4	0.8	0.9	-0.1	2.2	2.1
Vascular/heart problems diagnosed by doctor	1.7	4.5	11.6	-3.1	0.2	0.4	1.3	0.9	-3.0	-3.4	-2.6	-0.6	-1.8	-3.3
Medication: Co-codamol	1.6	1.8	3.5	1.9	0.7	1.1	-0.1	1.3	1.7	1.9	0.5	1.7	1.6	1.7
High blood pressure	1.6	4.6	11.7	3.0	0.2	-1.1	-1.2	-0.5	2.8	3.3	2.7	0.5	2.0	3.4
Body mass index (BMI)	1.6	6.8	18.1	4.3	-1.3	-0.1	-2.3	0.8	4.2	4.1	0.2	1.0	2.6	3.7
Lung cancer (father)	1.6	1.9	4.9	2.2	-1.1	1.1	-0.2	1.0	2.1	2.0	0.1	-0.4	1.7	1.7
Pulse wave Arterial Stiffness index	1.6	1.9	5.6	1.6	1.9	0.1	-0.7	0.8	1.3	1.6	0.5	2.4	1.8	1.4
Medication: Atenolol	1.5	1.9	4.3	1.5	-0.8	0.7	-1.8	-0.9	1.2	1.8	1.8	-0.5	2.1	1.7
Waist circumference	1.5	5.5	15.4	3.9	-0.8	-0.3	-1.8	0.9	3.9	3.7	-0.3	1.2	2.3	3.2
Birth weight of first child	1.5	2.6	6.3	-2.5	0.7	-1.8	-2.0	-1.6	-2.2	-1.6	-0.6	0.8	-1.4	-2.2
Hypertension (Self-reported)	1.5	4.1	10.0	2.8	0.1	-1.0	-1.0	-0.6	2.6	3.2	2.8	0.5	2.0	3.1
Average weekly red wine intake	1.5	2.2	11.6	-0.4	1.7	3.0	3.4	0.6	-0.9	-0.1	-0.5	-1.0	0.4	-0.3
Eye problems/disorders: Cataract	1.5	1.7	5.2	1.9	0.0	-0.5	-1.4	0.3	1.4	2.0	0.5	1.2	1.3	2.3
Breast cancer (self-reported)	1.5	1.8	6.7	1.2	-0.2	-0.7	-2.6	-2.5	1.4	1.8	1.0	0.1	0.4	0.7
Arm fat percentage (right)	1.4	5.4	15.2	3.9	-1.6	-0.2	-1.5	0.8	3.9	3.7	0.3	0.9	2.3	3.1
Worrier / anxious feelings	1.4	2.6	8.2	-2.4	0.8	-0.8	-0.0	-0.4	-2.6	-2.4	0.1	1.3	-1.3	-2.9
Depression (self-reported)	1.4	1.6	4.2	-1.6	1.0	-1.5	-0.5	-2.0	-1.6	-0.9	-0.7	0.4	-1.6	-1.7
Arm fat mass (right)	1.4	5.6	15.9	4.0	-1.3	-0.1	-1.4	1.0	3.8	3.8	0.1	0.9	2.6	3.3
Birth weight	1.4	3.0	9.3	-2.0	1.0	-1.5	-2.6	-2.6	-1.1	-1.3	0.2	1.0	-1.2	-3.0
Number of full brothers	1.4	1.8	5.1	1.5	-0.1	-0.2	-1.1	-2.2	1.8	2.3	0.7	-1.7	0.5	0.9
Suffer from ‘nerves’	1.4	2.2	5.6	-2.3	0.2	-0.3	1.0	0.3	-2.4	-1.9	-2.4	0.8	-0.6	-2.1
Commuting to job workplace: Public transport	1.4	1.7	3.1	1.2	-1.5	1.0	1.4	1.6	1.0	1.2	-1.8	-0.8	1.8	1.4
Body fat percentage	1.3	5.2	14.5	3.8	-1.2	-0.3	-1.3	1.3	3.8	3.2	-0.1	1.3	2.5	3.2
Leg fat mass (right)	1.3	4.9	13.9	3.7	-0.8	-0.2	-0.9	0.5	3.7	3.5	0.4	1.0	2.3	3.3
Overall health rating	1.3	2.7	17.7	0.5	0.6	-1.1	-4.2	-0.8	0.1	0.3	2.5	1.8	1.7	0.3
Illnesses of father: Heart disease	1.3	1.8	4.7	-0.1	-2.1	2.2	1.1	1.5	-0.6	-0.5	-1.9	-1.5	1.3	0.7
Arm fat percentage (left)	1.3	5.2	14.4	3.8	-1.3	-0.2	-1.9	0.9	3.8	3.6	0.2	1.1	2.2	3.0
Arm fat mass (left)	1.3	5.3	14.8	3.8	-1.0	-0.3	-1.5	0.8	3.7	3.7	0.1	1.0	2.4	3.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	6.9	0.8	-0.2	0.7	-1.0	1.5	0.1	0.8	2.0	0.4	2.6	1.5
Leg fat mass (left)	1.3	5.1	14.2	3.8	-0.8	-0.3	-1.2	0.7	3.8	3.5	0.2	1.0	2.3	3.4
Alzheimer’s Disease (in mother)	1.2	1.4	4.3	1.4	-2.1	0.4	0.1	0.9	1.1	1.4	-0.7	-0.3	1.7	1.7
Prostate Cancer	1.2	1.7	5.8	-0.1	0.7	2.4	1.3	2.3	-0.8	-0.5	-1.2	1.1	1.8	0.4
BMI	1.2	7.2	21.2	4.3	-1.3	0.2	-2.4	0.1	4.6	4.2	0.9	1.2	2.8	3.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.8	1.4	0.8	2.2	-0.4	0.4	1.1	0.7	0.1	2.0	0.7	1.2
Hair/balding pattern: Pattern 2	1.2	1.5	5.2	1.7	0.5	2.3	-0.9	0.9	1.2	1.4	0.9	0.0	1.3	1.5
Comparative body size at age 10	1.2	3.3	11.2	2.8	-1.2	-1.3	-1.7	-0.2	3.4	3.2	-0.4	-0.2	0.8	2.0
Emphysema/chronic bronchitis	1.2	1.4	5.4	1.4	-1.0	0.2	-1.3	0.3	0.7	1.3	2.3	-0.3	1.2	1.7
Medication for pain relief, constipation, heartburn	1.2	2.0	5.0	-2.1	-1.2	-0.9	0.5	-1.5	-1.6	-1.3	0.1	-2.2	-1.5	-2.0
Neck or shoulder pain in last month	1.2	1.7	7.9	-0.9	-0.2	-1.2	-2.8	-2.2	-0.7	-0.1	1.4	-0.6	-0.4	-1.5
Medication: Seretide 50 evohaler	1.2	1.3	5.3	0.3	1.6	-0.2	-2.3	0.4	0.0	0.4	1.6	1.8	1.1	0.6
Knee pain experienced in last month	1.2	1.8	7.4	1.3	1.7	-0.8	-2.0	0.3	1.2	0.9	-0.4	2.7	0.7	1.6
Ever had bowel cancer screening	1.2	1.4	7.2	0.2	-1.5	-0.7	0.2	-1.1	0.2	-0.1	2.7	-2.0	-0.9	0.6
Neuroticism (2016)	1.1	1.6	4.9	-1.6	0.1	-2.2	-0.7	-0.7	-1.6	-1.2	0.3	2.2	-0.5	-1.4
Hearing difficulty/problems with background noise	1.1	1.8	4.8	0.8	2.1	0.8	-1.6	0.6	1.1	0.9	-2.2	2.0	1.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	11.1	0.4	0.9	-0.8	-3.3	-1.4	0.1	0.5	2.2	-0.3	1.2	0.2
Length of working week for main job	1.1	1.2	4.7	-0.4	0.7	1.7	1.1	1.2	-1.0	-0.1	0.0	2.2	1.5	-0.5
Exposure to tobacco smoke at home	1.1	1.2	3.8	1.0	-0.8	-0.7	-2.0	-1.3	0.9	1.1	1.2	-1.7	0.6	0.4
Family relationship satisfaction	1.1	1.4	3.7	1.5	1.4	1.0	-0.7	0.9	1.5	1.4	1.1	0.3	0.9	1.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	6.1	-0.5	1.8	-1.2	1.1	0.5	-0.6	-0.9	0.2	2.5	-1.1	-0.0
Osteoporosis (self-reported)	1.1	1.4	3.4	-1.4	1.3	-1.1	-1.2	0.7	-1.1	-1.6	-0.8	1.8	-1.1	-1.0
Smoking status: Current	1.1	1.7	6.9	1.3	-1.2	-0.8	-1.1	-1.1	0.9	1.3	2.6	-1.9	0.5	0.8
Number of operations (self-reported)	1.1	1.6	4.6	1.0	1.9	1.1	-2.1	1.3	1.0	0.3	0.7	1.6	1.1	1.5
Heart disease (siblings)	1.1	1.3	3.3	1.3	1.8	-0.7	-1.0	-1.0	1.5	1.7	-0.8	0.9	0.5	1.2
Major Depression (MDD)	1.0	1.2	2.9	-1.7	-0.1	-1.2	-1.4	-0.3	-1.7	-1.3	0.6	0.8	-0.8	-1.2
Reaction Time	1.0	1.8	7.8	-2.0	0.6	1.6	0.0	-0.5	-2.8	-1.1	1.7	-0.0	0.4	-1.6
Trunk fat percentage	1.0	3.9	10.3	3.2	-1.3	-0.2	-0.9	1.7	3.2	2.5	-0.4	1.4	2.3	2.7
Age when periods started (menarche)	1.0	2.3	7.7	-2.1	1.1	-1.2	-1.4	-0.4	-1.6	-1.7	-1.7	0.0	-1.4	-2.8
Qualifications: CSEs or equivalent	1.0	1.3	6.4	1.2	-2.5	-1.1	-1.2	0.9	1.3	0.4	-1.0	-0.7	0.8	0.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	8.8	0.5	0.2	-0.9	-3.0	-1.4	0.9	1.0	-0.1	0.3	0.2	0.2
Chronic bronchitis/emphysema (father)	1.0	1.1	3.2	-0.9	1.1	-0.8	-1.4	-1.6	-0.6	-0.6	0.3	1.8	-1.0	-1.0
Forced vital capacity (FVC)	1.0	3.8	14.2	-3.8	0.7	-0.2	-0.1	-0.5	-3.6	-2.6	-0.9	0.6	-0.8	-2.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	10.8	-3.2	0.4	-0.6	-0.3	-1.4	-3.3	-2.3	0.1	-0.1	-1.4	-3.0
Forced vital capacity (FVC), Best measure	1.0	3.8	12.4	-3.4	0.8	-0.4	0.2	-1.2	-3.5	-2.8	-0.4	0.3	-1.5	-2.9
Shortness of breath walking on level ground	1.0	1.2	3.2	1.2	0.9	0.2	-1.7	-0.4	0.5	0.9	1.8	1.6	1.0	1.3
Mean time to correctly identify matches	1.0	1.9	5.9	-2.0	1.3	0.8	0.5	-0.6	-2.4	-1.5	2.0	-0.1	-0.6	-1.7
Whole body fat mass	1.0	4.3	11.8	3.4	-0.8	-0.4	-1.2	1.0	3.3	3.1	0.0	1.2	2.3	2.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.8	1.7	0.2	0.5	1.6	0.8	2.0	1.1	-1.3	0.7	-0.6	1.5
Risk taking	1.0	1.5	4.2	1.7	-0.1	0.5	0.2	0.2	1.1	1.6	2.1	-1.0	1.9	1.6
Unable to work because of sickness or disability	1.0	1.3	3.3	1.3	0.6	-0.8	-1.8	-0.6	1.1	1.7	1.3	0.8	1.0	1.3
Chronotype (morning person)	0.9	2.1	6.9	-1.7	0.6	1.2	1.0	2.6	-2.5	-1.8	-1.3	0.8	0.8	-0.7
Sensitivity / hurt feelings	0.9	1.5	4.7	-1.4	1.0	-0.2	2.2	0.6	-1.6	-1.7	-0.7	1.3	-0.7	-1.3
Relative age voice broke	0.9	1.4	6.4	0.6	1.6	-1.2	-0.8	-2.5	1.2	0.6	0.2	1.3	-1.5	-0.1
Serious illness, injury or assault to yourself	0.9	1.0	2.0	1.4	0.8	-0.9	-0.4	0.6	1.1	1.4	1.2	0.9	1.2	1.4
Trunk fat mass	0.9	3.7	10.3	3.2	-0.7	-0.2	-1.0	1.2	3.1	2.7	-0.1	1.5	2.2	2.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	11.7	-3.4	0.4	-0.8	-0.6	-1.2	-3.3	-2.1	-0.1	-0.1	-1.0	-2.8
Pulse rate	0.9	1.5	3.6	1.9	-0.7	-0.1	-1.0	-0.6	1.9	1.8	0.9	-0.5	1.0	1.9
Noisy workplace	0.9	1.1	4.0	0.9	-0.3	1.5	0.7	1.5	0.6	0.2	-0.3	0.9	1.2	2.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	11.6	0.1	-1.7	-0.1	1.1	0.7	0.0	0.4	-1.0	-3.4	0.0	-0.1
Health satisfaction	0.9	1.1	10.6	0.8	0.3	0.2	-3.3	-0.6	0.9	0.6	-0.3	0.4	0.5	0.3
Medication: Blood pressure	0.9	1.6	4.2	1.5	0.6	-2.0	-1.1	-1.4	1.5	2.0	1.0	0.6	-0.4	1.2
Migraine (self-reported)	0.9	1.1	5.8	-0.3	-0.8	2.4	0.4	1.6	-1.0	-0.9	-0.6	-0.8	1.1	-0.3
Had major operations	0.9	1.1	5.7	0.6	1.0	0.2	-2.4	1.0	0.7	0.6	-1.6	0.7	1.0	0.6
Leg pain on walking	0.9	1.1	3.6	1.3	-0.4	-1.0	-1.9	-0.6	1.3	1.0	0.0	1.8	0.4	0.6
Long-standing illness, disability or infirmity	0.9	1.3	4.9	1.4	1.0	-0.4	-2.2	0.1	0.8	1.0	0.9	0.9	1.5	1.4
Ever taken oral contraceptive pill	0.9	0.9	2.3	1.4	1.5	0.7	-0.6	0.7	1.4	1.4	0.2	0.1	0.8	1.2
Financial situation satisfaction	0.9	1.1	3.1	1.3	1.1	-0.4	-1.4	-0.7	1.2	1.8	0.5	0.6	1.2	1.1
Irritability	0.9	1.5	4.5	-2.0	-0.6	1.1	1.1	-0.3	-2.1	-1.7	-0.2	-0.7	0.4	-1.8
Alzheimer’s Disease (including proxy)	0.8	1.2	3.0	1.3	-0.9	0.2	0.2	1.0	1.1	1.4	-1.5	0.2	1.4	1.7
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.8	1.7	0.6	-0.1	-1.2	1.8	1.2	1.2	-0.8	0.6	2.0	1.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.9	0.9	-0.7	0.1	-1.4	1.1	0.3	0.6	1.2	1.2	1.7	1.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	1.3	0.4	0.2	-0.8	0.4	1.5	0.7	1.6	1.4	0.1	1.1
Current tobacco smoking	0.8	1.3	5.2	1.3	-0.9	-0.9	-0.9	-0.8	0.9	1.2	2.3	-1.4	0.7	1.1
Average weekly fortified wine intake	0.8	0.9	2.2	-0.9	1.5	1.0	1.3	0.7	-1.2	-1.3	-0.1	1.1	-0.3	0.1
Medication: Cholesterol lowering	0.8	1.2	3.6	1.6	0.1	-0.5	-1.0	0.5	1.1	1.7	1.2	0.5	0.8	1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.4	-1.5	-0.7	1.3	0.9	0.6	-1.4	-1.9	-1.7	-0.2	-0.2	-1.6
Glaucoma (self-reported)	0.8	1.0	2.2	-1.4	-0.3	-0.7	-1.2	-1.3	-0.9	-1.5	0.9	-0.7	-1.3	-0.4
Worry too long after embarrassment	0.8	1.4	3.8	-1.5	-0.4	0.3	0.7	0.4	-1.8	-2.0	-0.8	-1.7	-0.1	-1.7
Medication: Aspirin	0.8	1.0	8.1	-0.4	1.0	0.0	-0.9	0.6	-0.4	-0.6	-1.1	2.8	-0.3	-0.5
Friendships satisfaction	0.8	1.0	2.8	-0.4	1.2	1.7	1.5	1.0	-0.7	-1.3	1.4	-0.3	0.4	0.4
Mineral and other dietary supplements	0.8	1.1	4.5	-1.1	-0.3	-0.4	-2.1	-1.0	-1.6	-0.4	0.7	-0.1	0.9	-1.4
Osteoarthritis (self-reported)	0.8	1.0	4.8	0.2	1.4	1.2	-0.2	2.2	-0.4	-0.2	0.9	0.6	1.1	0.8
Medication: Aspirin	0.8	1.0	8.2	-0.0	1.0	-0.1	-0.6	0.7	-0.0	-0.1	-1.5	2.9	-0.0	0.1
Medication: Blood pressure	0.8	1.4	3.4	1.7	-0.9	0.5	0.6	0.1	1.1	1.9	1.4	-0.9	1.6	1.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.1	1.1	0.7	2.3	-0.2	0.9	0.3	0.4	0.8	-0.1	1.5	0.8
Medication: Lisinopril	0.8	1.1	3.0	-1.1	-0.5	-1.4	-0.6	-1.7	-0.8	-0.8	-0.3	-1.1	-1.2	-1.5
Rheumatoid Arthritis	0.7	1.0	2.9	-1.0	1.3	-0.7	1.7	-0.3	-1.1	-0.9	1.5	0.7	-0.5	-0.5
Triglycerides	0.7	1.1	7.0	-0.2	1.0	1.1	1.3	-1.0	-0.8	-0.2	2.6	-0.3	0.2	0.1
Hypothyroidism (self reported)	0.7	1.7	10.4	0.6	-0.9	-1.3	-1.5	-1.4	0.7	1.2	0.7	-3.2	0.2	-0.5
Number of treatments/medications taken	0.7	1.2	5.5	0.9	1.1	-0.7	-1.1	-0.6	0.5	1.0	2.4	1.6	-0.0	1.1
Medication for hormone replacement therapy	0.7	0.8	3.1	0.8	0.1	1.8	-0.2	0.4	0.9	0.6	-1.4	1.4	0.5	0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	4.1	0.4	1.3	0.4	1.3	0.1	0.4	0.1	1.4	2.0	-0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	6.4	0.2	-1.4	1.0	-0.2	0.5	-0.2	0.7	2.5	-2.0	2.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.4	-0.8	1.0	-0.4	-1.1	-1.5	-0.5	-0.1	-0.1	0.9	-1.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	5.7	-0.4	-1.3	0.5	-2.4	-0.8	-0.8	-0.3	1.0	-1.4	0.4	-0.7
Had menopause	0.7	0.8	3.2	-0.2	1.4	1.1	0.9	0.4	0.5	-0.2	-1.2	1.8	-0.7	-0.6
Number of live births	0.7	1.0	4.7	1.2	0.1	1.5	-0.6	0.0	1.5	0.6	2.2	0.9	-0.5	0.7
Impedance of arm (left)	0.7	3.1	9.1	-2.9	0.0	0.1	1.4	0.4	-2.8	-3.0	-0.6	0.4	-1.5	-2.6
Breastfed as a baby	0.7	0.9	5.9	-0.0	1.2	-0.6	-0.5	-2.4	0.3	0.4	0.5	1.0	-1.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.6	-1.3	0.3	-0.8	0.7	-1.6	-1.6	-1.4	-0.2	0.4	-0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	3.2	0.5	-1.8	-0.5	-0.8	-1.6	0.7	0.9	0.2	-1.8	0.0	-0.4
Medication: Paracetamol	0.7	1.2	3.9	2.0	-0.7	0.1	0.4	1.3	1.8	0.9	-0.8	0.7	0.1	1.6
High blood pressure (siblings)	0.7	0.9	2.8	1.2	-0.9	-1.3	-0.8	-0.2	1.3	1.3	-0.5	-0.5	0.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.1	-0.1	0.8	-0.6	1.4	-2.0	-0.1	-0.1	0.9	0.7	-1.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	4.1	-0.8	0.1	0.3	2.0	1.4	-1.2	-0.9	-0.4	0.2	0.3	-0.1
Age at first live birth	0.7	1.3	6.6	-0.9	2.6	1.2	-1.3	0.7	-1.4	-0.5	-1.1	-0.6	0.7	-0.6
Eye problems/disorders: None of the above	0.7	0.8	4.0	-0.5	0.3	0.7	2.0	0.3	-0.3	-1.1	-0.9	-0.5	-1.1	-1.1
Medication: Omeprazole	0.7	0.8	4.2	0.2	-0.0	0.6	0.0	0.7	-0.3	0.2	2.1	0.6	1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	4.4	-2.1	-0.1	-0.3	-0.2	-0.2	-2.0	-1.4	-0.6	-1.6	-0.3	-1.9
Number of self-reported non-cancer illnesses	0.7	1.3	4.1	1.4	-0.3	-0.2	-1.6	-0.0	0.8	1.2	2.0	0.0	1.1	1.8
Miserableness	0.7	1.3	4.1	-1.4	-0.7	-2.0	-1.0	-0.7	-1.7	-1.5	-0.6	-0.7	-0.9	-0.8
Hearing aid user	0.7	0.7	2.1	1.5	0.2	0.4	-0.3	0.2	1.4	1.4	-0.1	1.1	0.7	0.8
Illnesses of father: High blood pressure	0.7	0.9	4.4	0.7	-0.5	-1.3	-2.1	-0.1	0.1	1.0	0.8	-0.4	1.3	0.4
Ever smoked	0.7	1.3	3.6	1.9	-0.5	0.4	-0.5	-0.6	1.4	1.7	0.7	-0.1	1.3	1.9
Pain experienced in last month	0.7	1.1	3.4	-1.3	-0.2	-0.3	1.8	-1.2	-1.1	-0.9	0.1	-1.1	-1.3	-1.3
Alzheimer’s Disease (in father)	0.6	0.6	2.6	0.3	1.6	-0.7	0.2	0.6	0.5	0.3	-1.4	0.9	0.2	0.5
Lupus	0.6	0.9	3.8	-0.4	0.7	0.6	1.8	1.9	-0.9	-1.1	-0.0	0.4	0.1	1.1
Heel T-Score	0.6	4.4	10.7	2.5	-2.1	0.7	-1.0	-1.2	1.8	3.1	2.0	-3.3	2.7	2.3
Lung FVC	0.6	3.3	8.5	-2.9	0.9	-0.7	-0.8	-1.8	-2.6	-2.2	0.1	-0.1	-2.4	-2.9
Hearing difficulty/problems: Yes	0.6	0.9	4.0	-0.2	1.7	-0.3	-0.2	-0.5	0.4	-0.3	-2.0	1.6	-1.0	-0.3
Medication: Metformin	0.6	0.8	2.9	0.6	1.7	0.0	-1.2	0.1	0.1	0.8	0.7	0.8	1.5	1.0
Pack years adult smoking proportion	0.6	0.9	4.2	0.4	-1.5	0.3	-0.3	0.1	-0.4	0.5	2.0	-1.1	1.4	0.0
Townsend deprivation index at recruitment	0.6	0.8	2.3	0.7	-1.2	0.1	-0.9	-1.5	1.2	0.6	1.5	0.7	-0.0	0.7
Taking other prescription medications	0.6	0.9	3.2	0.5	0.3	-0.6	-1.8	0.2	-0.0	0.4	1.6	1.1	1.0	1.2
Stomach or abdominal pain in last month	0.6	0.7	4.3	0.5	0.0	0.5	-2.1	0.0	0.5	1.2	0.3	0.3	1.3	-0.1
Supplements: Glucosamine	0.6	0.8	3.7	0.7	1.0	1.2	1.9	1.0	0.5	0.5	0.4	0.7	0.4	0.6
Alcohol usually taken with meals	0.6	0.9	6.7	0.3	0.5	1.7	2.6	0.1	0.2	0.4	0.4	-0.7	0.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.9	0.1	1.7	-1.4	-1.1	-1.1	-0.2	0.5	1.0	-0.2	-0.6	0.0
Mouth/teeth dental problems	0.6	0.9	3.4	-0.4	1.4	1.2	0.5	1.3	-0.6	-0.6	-0.8	1.9	0.6	0.3
Weight	0.6	3.2	8.2	2.9	-0.2	-0.2	-1.1	0.7	2.7	2.8	-0.1	1.5	2.1	2.5
Hip circumference	0.6	2.4	6.8	2.6	-0.2	-0.6	-0.9	0.1	2.6	2.4	-1.0	1.3	1.2	2.0
Alcohol intake versus 10 years previously	0.6	0.9	6.9	-0.5	1.5	-0.1	-1.0	-0.2	-0.5	-0.2	0.2	2.6	-0.2	-0.2
Father’s age at death	0.6	0.8	2.4	-1.4	0.3	1.0	-0.4	-0.4	-1.2	-1.6	-0.2	-0.5	-0.6	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	5.4	0.6	-1.4	1.2	0.9	-0.3	0.7	0.7	-2.1	-2.3	0.5	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	6.0	0.6	0.1	-1.0	-0.3	-0.9	0.9	0.5	2.5	1.2	-0.8	0.8
Hair/balding pattern: Pattern 4	0.6	1.5	5.8	-2.2	0.9	0.2	-0.6	-0.3	-2.4	-1.9	-0.1	0.4	-0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	7.8	0.7	-0.8	-0.7	-0.8	-0.9	0.8	0.9	1.1	-2.8	0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.8	3.9	0.6	-1.7	0.1	0.4	0.5	0.3	0.2	-0.4	-2.0	1.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.6	0.4	-1.9	-0.3	-1.2	-1.1	0.4	0.8	-1.0	0.3	-0.3	-0.6
Qualifications: nursing, teaching	0.6	1.0	5.9	0.0	-2.0	0.7	-0.7	0.6	-0.4	0.1	0.1	-2.4	0.6	-0.1
Wears glasses or contact lenses	0.6	0.7	4.4	0.5	-0.3	1.1	1.0	0.5	0.6	0.2	-2.1	0.1	-0.5	0.6
Mother’s age at death	0.6	0.8	5.4	-0.2	-0.8	-1.3	-2.3	-0.1	0.0	-0.4	0.4	-0.5	-0.2	-0.9
Alcohol drinker status: Never	0.6	0.8	2.2	-1.3	-0.3	-1.1	-0.6	-0.7	-0.8	-0.3	-1.3	0.3	-0.6	-1.5
Average weekly beer plus cider intake	0.6	0.8	3.5	0.9	0.3	-0.1	-1.6	-1.9	1.2	1.1	0.1	0.4	-0.1	0.2
Age started oral contraceptive pill	0.6	0.8	3.1	-0.4	1.2	-1.2	0.3	0.2	-0.1	-0.9	-1.8	0.9	-1.2	-0.2
Ever depressed for a whole week	0.6	0.7	2.5	-1.1	1.5	-0.7	-0.2	-1.0	-1.6	-0.3	0.6	-0.5	-0.2	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	3.5	0.6	1.9	0.8	0.3	0.4	0.7	0.5	0.3	1.8	0.0	0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.6	-1.3	-0.8	1.5	0.8	-0.1	-1.6	-0.9	0.6	-0.3	0.2	-0.9
Alcohol drinker status: Previous	0.6	0.6	2.7	0.9	-0.7	1.6	0.7	0.9	0.5	0.1	-0.3	0.2	1.2	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	4.6	-1.9	0.4	0.3	0.8	-0.4	-2.1	-1.4	-0.3	-0.2	-1.1	-1.5
Ulcerative Colitis (UC)	0.5	1.0	3.3	-0.8	1.8	0.5	0.5	1.5	-1.5	-1.0	1.2	-0.2	0.5	0.3
Age at First Birth	0.5	0.7	2.0	-1.1	0.5	-0.1	-1.1	-0.5	-1.2	-0.7	-0.8	-0.6	-0.7	-1.4
HDL Cholesterol	0.5	0.8	2.0	-0.4	-1.4	-0.2	1.2	1.1	-0.4	-0.5	-1.4	-1.4	-0.0	-0.5
Blood Platelet Count	0.5	6.1	46.1	0.5	2.0	1.4	0.8	0.8	1.4	0.2	-4.2	6.8	-0.1	-0.6
Average weekly spirits intake	0.5	0.6	4.7	0.0	0.1	0.5	-2.2	0.4	-0.6	0.3	0.5	-0.1	1.3	-0.1
Vitamin and mineral supplements	0.5	0.7	3.1	0.1	0.4	1.4	-0.3	0.7	-0.7	-0.0	1.0	-0.9	1.8	-0.1
Fed-up feelings	0.5	0.8	3.1	-0.7	-0.3	-1.8	-1.6	-1.3	-0.6	-0.3	0.2	0.1	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	10.0	-0.1	-0.7	0.6	0.6	-0.0	-0.7	0.5	3.2	-0.8	1.1	0.4
Financial difficulties in last 2 years	0.5	0.6	1.7	1.0	1.3	0.5	-0.5	-0.8	1.0	1.3	0.7	0.3	0.1	0.7
Pain all over the body in last month	0.5	0.6	1.8	0.5	0.2	-1.2	-0.8	1.4	0.5	-0.4	-0.3	1.1	0.4	0.6
Illnesses of siblings	0.5	0.8	2.4	-1.3	-0.1	0.8	0.6	0.5	-1.3	-1.4	0.1	0.6	-0.4	-1.5
Impedance of arm (right)	0.5	2.4	6.7	-2.4	-0.4	-0.1	1.4	0.3	-2.4	-2.6	-0.1	0.3	-1.2	-2.5
Time employed in main current job	0.5	0.5	2.4	0.2	1.0	0.1	0.6	-0.8	0.6	1.6	-1.0	0.5	-0.1	-0.6
Medication: Lansoprazole	0.5	0.5	1.3	0.6	-0.1	0.7	-1.1	-0.6	0.5	0.9	0.7	0.9	1.0	0.8
Pulse wave reflection index	0.5	0.6	3.0	-0.2	1.3	-0.3	0.3	0.7	-0.7	-0.1	0.8	1.7	1.0	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.5	-0.8	-0.1	0.8	-0.0	0.7	-1.3	-0.6	-1.6	0.6	-0.1	-0.5
Exposure to tobacco smoke outside home	0.5	0.6	3.8	0.2	-0.4	-1.9	-0.9	0.1	0.4	0.5	-1.1	1.0	0.4	-0.0
Wheeze or whistling in the chest in last year	0.5	0.9	7.4	0.6	-0.4	0.3	-2.7	0.9	0.5	-0.3	0.9	0.2	1.0	-0.2
Pulse rate, automated reading	0.5	1.5	4.2	1.7	0.4	-1.2	-1.2	-0.7	2.0	2.0	-0.0	0.2	1.1	1.3
Age at last live birth	0.5	0.7	4.3	0.1	1.3	-0.1	-2.1	0.3	-0.0	0.1	-0.3	-1.1	0.4	0.8
Supplements: Vitamin C	0.5	0.6	1.9	0.0	0.5	-1.4	1.1	0.8	0.1	-0.1	-1.3	0.9	0.4	0.9
Smoking status: Previous	0.5	0.7	4.4	0.3	0.4	1.1	0.2	0.7	0.2	0.1	-1.0	2.1	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.7	0.6	0.2	1.8	0.6	1.3	-0.3	0.6	0.9	-0.5	2.2	0.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	0.7	1.1	-0.9	0.9	-0.6	1.0	0.6	1.3	0.3	-1.0	-0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.9	0.7	0.6	-0.2	1.3	-0.1	0.5	0.5	-1.7	0.2	-0.3	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	3.2	-1.0	1.1	0.4	0.2	1.8	-1.5	-1.3	0.6	0.3	0.7	0.1
Crohns Disease (2012)	0.4	0.7	2.4	0.8	0.6	0.5	0.0	0.7	0.8	0.5	1.6	1.2	0.6	1.1
LDL Cholesterol	0.4	0.6	1.9	-1.1	0.3	0.0	0.3	-0.1	-1.0	-1.2	0.4	1.0	-0.8	-1.4
Smoking Status	0.4	1.0	3.9	1.6	-0.6	-0.0	-0.7	-0.6	2.0	1.2	0.8	0.8	0.5	1.1
Allergy or Eczema	0.4	1.0	5.7	0.3	0.9	0.0	-2.4	0.1	0.7	0.3	-1.5	1.4	0.9	-0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.8	-1.0	0.7	-0.1	-0.6	-0.3	-1.7	-0.9	1.0	-0.5	0.5	-0.7
Relative age of first facial hair	0.4	0.9	3.0	0.5	-0.2	-0.5	-1.7	-1.7	1.3	0.9	-0.2	0.2	-0.7	-0.8
Severe depression (siblings)	0.4	0.5	1.2	-1.0	-0.6	-0.8	-0.6	-1.1	-0.9	-0.5	-0.1	0.2	-0.7	-0.8
Multivitamins +/- minerals	0.4	0.5	1.5	0.8	-0.5	0.7	-0.3	-0.9	1.2	1.0	0.1	1.1	-0.7	0.4
High blood pressure (mother)	0.4	0.6	3.1	-0.3	-0.9	-0.6	-1.7	-1.1	-0.6	0.4	0.9	-0.4	0.1	-0.3
Past tobacco smoking	0.4	0.7	1.7	-1.2	0.0	-0.9	0.3	-0.2	-0.8	-1.0	-0.2	-1.1	-1.3	-1.3
Had other major operations	0.4	0.5	3.6	-0.6	1.9	0.4	-0.9	0.2	-0.8	-0.6	0.5	0.6	0.3	0.1
Heart attack	0.4	0.5	1.8	-0.9	-0.8	1.3	0.5	-0.1	-1.2	-0.6	0.8	0.0	0.1	-0.6
Diabetes (self-reported)	0.4	0.6	1.6	0.9	1.3	-0.7	-0.2	0.7	0.4	0.5	-0.2	1.0	0.9	1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.5	0.5	-1.0	-0.9	-1.6	0.9	0.3	0.1	-0.3	-0.3	0.8	0.5
Fluid intelligence score	0.4	0.8	2.1	1.0	-0.1	1.4	0.6	-0.6	0.7	1.2	1.2	-1.5	0.9	0.1
Falls in the last year	0.4	0.5	1.7	1.0	-0.1	0.1	-0.8	0.4	0.6	1.1	-0.2	-0.3	1.3	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.2	-0.5	-0.2	-1.2	1.5	-1.2	-0.4	-0.4	0.4	0.1	-0.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.7	0.0	-0.1	1.1	0.6	1.3	-0.4	-0.7	-0.3	-0.2	0.9	-0.4
Loud music exposure frequency	0.4	0.4	2.6	-0.1	1.0	0.8	-0.1	-0.2	0.0	-0.2	-0.4	1.6	-0.3	-0.3
Headache pain in last month	0.4	0.7	3.6	-0.7	1.1	-0.6	-0.3	-0.6	-0.9	-0.6	0.1	1.9	-0.8	-1.0
Number of children fathered	0.4	0.4	2.1	0.4	0.4	-0.2	1.0	-0.1	0.6	0.2	-1.5	0.7	-0.2	-0.7
Medication: Ibuprofen	0.4	0.5	1.6	0.8	1.2	0.2	0.4	0.4	0.5	0.6	0.4	1.0	0.2	1.1
Medication: Allopurinol	0.4	0.5	1.5	-0.7	-0.9	0.7	1.2	0.2	-0.3	-0.7	0.2	-0.8	-0.8	-1.1
Alcohol intake frequency.	0.4	0.8	3.5	-0.0	-1.2	0.2	-1.9	0.4	0.3	-0.2	-1.8	0.9	0.2	-0.7
Chest pain or discomfort	0.4	0.6	3.0	0.4	-0.4	1.3	-1.7	0.2	-0.4	0.1	0.6	0.6	1.3	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.5	0.9	-0.2	-0.1	-0.7	-0.4	0.9	1.2	0.4	0.2	0.4	0.9
Medication for cholesterol	0.4	0.6	1.7	-1.1	0.3	-1.3	-0.1	0.5	-0.8	-1.0	-0.1	-0.7	-0.9	-1.0
Medication: Gliclazide	0.4	0.4	1.8	-0.2	-0.5	-0.7	-0.6	0.6	-0.3	-0.3	1.4	1.2	-0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	3.7	0.1	0.0	1.0	-0.1	1.9	0.1	-0.8	-0.2	-0.2	0.2	0.2
Medication: Paracetamol	0.4	0.7	2.7	1.6	-0.3	-0.5	0.7	-0.0	1.3	1.0	0.2	0.6	-0.2	1.1
Pack years of smoking	0.4	0.6	3.6	0.5	-1.0	0.2	-0.2	0.2	-0.3	0.4	1.9	-0.5	1.4	0.2
Impedance of whole body	0.4	2.3	7.8	-2.4	-0.1	0.1	1.6	0.5	-2.3	-2.8	-0.6	-0.2	-1.0	-2.1
Depression (Nagel 2018)	0.3	0.5	1.6	-0.8	1.2	-0.9	-0.6	-0.4	-1.2	-0.8	0.0	-0.0	0.0	-0.3
Crohns Disease (2017)	0.3	0.7	2.2	-0.5	0.6	0.8	0.1	1.5	-1.0	-0.8	0.9	1.1	1.4	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-1.0	0.7	0.2	0.0	-0.7	-0.7	-0.8	-0.0	0.6	-0.5	-0.9
Primary Biliary Cirrhosis	0.3	0.4	2.3	-0.1	0.9	-0.8	1.5	-0.6	-0.4	-0.2	-0.6	0.6	-0.4	0.4
Ulcerative Colitis	0.3	0.4	1.0	-0.9	0.6	-0.3	0.5	0.1	-1.0	-1.0	-0.6	-0.1	-1.0	-0.6
Blood White Count	0.3	2.0	9.1	2.1	-2.2	-0.8	-1.2	0.1	3.0	1.6	-0.3	0.5	0.0	1.1
Systolic blood pressure, automated reading	0.3	0.9	4.9	0.7	0.7	-1.3	-0.0	-2.2	1.0	0.8	0.6	0.1	-1.0	0.6
Angina	0.3	0.4	3.0	0.0	-0.1	1.7	-0.3	0.8	-0.6	-0.0	-0.5	0.3	0.9	-0.4
Diabetes (father)	0.3	0.3	1.5	0.3	-1.2	0.1	-0.3	0.4	0.6	0.7	-0.4	-0.9	0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.6	0.1	0.5	-0.7	-1.6	-0.6	-0.1	0.0	0.4	0.5	0.9	0.1
Medication: Levothyroxine sodium	0.3	0.5	3.0	-0.4	-0.1	-0.3	-1.1	-0.2	-0.6	-0.1	0.0	-1.7	0.3	-1.0
Qualifications: None of the above	0.3	0.7	2.7	-0.8	0.1	0.1	1.6	0.8	-0.8	-1.2	0.2	1.4	-0.1	-0.2
Medication: Ramipril	0.3	0.4	1.8	-0.2	1.3	-1.2	-0.2	-0.9	-0.2	0.4	0.5	-0.4	-0.2	0.2
Medication: Simvastatin	0.3	0.5	2.3	-0.0	0.3	-1.5	-1.1	-0.9	-0.3	0.1	0.2	0.6	-1.1	0.1
Asthma	0.3	0.6	1.8	-0.6	1.0	1.2	-0.4	-0.1	-0.5	-1.0	0.7	1.3	-0.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	0.5	1.2	0.3	0.4	0.2	0.5	0.3	0.1	1.0	-0.1	0.9
Standing height	0.3	2.8	7.1	-2.3	2.1	-0.2	2.5	-0.1	-2.7	-2.1	-0.8	1.1	-0.7	-2.0
Qualifications: College or University degree	0.3	1.1	3.5	-0.1	1.7	1.9	1.0	1.5	-0.5	-0.2	-0.4	-0.1	1.3	1.0
Angina (self-reported)	0.3	0.4	2.1	-0.2	-0.1	1.4	-0.3	0.7	-0.8	-0.2	-0.4	0.5	0.7	-0.7
Heart disease (mother)	0.3	0.3	1.3	0.4	-0.7	0.8	0.9	1.1	0.2	-0.0	-0.5	-0.2	0.2	0.5
Comparative height size at age 10	0.3	1.6	9.1	-0.3	3.0	-0.4	1.1	0.6	-1.0	-0.1	-0.5	2.5	0.9	0.6
Illnesses of siblings: Diabetes	0.3	0.3	1.1	-0.3	-1.1	-0.8	-0.1	0.8	-0.3	-0.7	-0.8	0.5	0.1	0.3
Loneliness, isolation	0.3	0.4	1.9	-0.8	0.8	-0.9	-1.4	0.0	-0.7	-0.5	0.1	-0.6	-0.0	-0.6
Diabetes diagnosed by doctor	0.3	0.5	1.3	0.9	1.1	-0.1	-0.4	0.9	0.2	0.5	0.4	0.8	1.0	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.1	0.6	0.3	-0.2	-1.5	0.1	0.7	0.7	-1.1	-0.7	0.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.4	0.1	0.9	-0.2	-0.6	1.2	-0.6	0.2	0.2	-0.0	0.8	0.0
Average weekly champagne plus white wine intake	0.3	0.4	2.7	0.4	-0.5	0.7	1.6	-0.2	0.1	0.2	0.5	-0.1	0.2	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	-0.6	-0.7	-0.4	-0.4	-0.9	-0.2	-0.6	-0.4	-1.1	-0.7	0.1
Arm fat-free mass (left)	0.3	1.4	4.8	1.9	-0.0	-0.5	-0.6	-0.3	1.5	2.2	-0.1	0.2	1.5	1.7
Fractured/broken bones in last 5 years	0.3	0.4	1.6	0.1	-0.9	-0.2	0.9	0.1	0.7	0.4	-0.9	-1.3	-0.8	-0.2
Supplements: Calcium	0.3	0.4	2.4	-0.5	-0.2	-0.4	-0.9	0.3	-0.7	0.3	1.5	-0.0	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.1	-0.1	1.1	0.7	0.7	0.9	-0.6	-0.1	0.4	0.4	0.4	0.4
Arm predicted mass (left)	0.3	1.6	5.7	2.1	-0.2	-0.5	-0.7	-0.4	1.7	2.4	-0.0	-0.0	1.6	1.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	1.0	-0.4	0.1	-0.3	0.4	0.8	0.7	0.1	-1.2	0.7	0.5
Ovarian Cancer	0.2	0.3	1.3	0.2	0.7	-0.1	-0.3	-0.8	0.5	0.3	-0.3	1.1	-0.7	0.1
Coronary Artery Disease (CAD)	0.2	0.3	1.4	-0.0	-0.4	-0.5	-0.5	-0.3	0.2	-0.1	1.2	0.9	-0.1	-0.2
Mean Putamen Volume	0.2	0.2	0.8	0.3	0.9	-0.1	-0.3	0.7	0.5	-0.3	0.0	0.8	-0.5	0.3
HbA1C	0.2	0.3	1.4	0.3	-0.7	1.2	0.6	0.1	0.8	0.1	-0.4	0.3	0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.4	-0.4	0.2	-1.2	0.1	-0.5	-0.5	0.1	0.6	0.2	-0.2	-0.6
Blood Eosinophil Count	0.2	1.2	3.8	1.5	-1.0	-0.8	-1.2	0.1	1.9	1.2	-1.4	0.6	-0.1	1.4
Height	0.2	3.8	11.7	-2.9	1.5	-0.8	3.1	-0.4	-3.4	-2.2	-1.6	1.7	-0.3	-1.7
Waist Hip Ratio (WHR)	0.2	1.0	2.7	1.2	-1.3	-0.2	-1.2	1.1	1.6	1.2	-0.6	0.0	1.1	0.7
Systolic Blood Pressure	0.2	1.2	7.0	0.1	1.3	-0.8	-0.5	-2.6	-0.0	0.4	1.9	-0.6	-0.9	0.1
Lung FEV1/FVC ratio	0.2	1.3	3.6	-0.9	1.1	-1.0	0.8	-1.4	-1.2	0.0	1.2	0.7	-1.9	-1.7
Hand grip strength (left)	0.2	0.5	1.3	0.5	-0.5	1.1	1.0	-0.0	0.4	1.0	-0.7	-1.0	0.5	0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	0.7	-0.5	0.9	0.2	-0.4	0.7	0.2	-0.0	1.0	0.3	0.6
Impedance of leg (right)	0.2	1.2	5.9	-1.3	1.0	0.2	2.4	0.0	-1.4	-1.7	0.1	-0.0	-0.3	-0.9
Leg fat-free mass (left)	0.2	0.8	2.5	1.3	-0.6	-0.0	-0.9	0.1	1.1	1.6	-0.0	0.5	1.3	1.1
Impedance of leg (left)	0.2	0.9	3.1	-1.2	0.8	-0.1	1.5	0.4	-1.4	-1.8	-0.1	-0.0	-0.4	-0.8
Leg predicted mass (left)	0.2	0.9	2.9	1.4	-0.6	-0.0	-0.9	0.1	1.2	1.7	0.1	0.5	1.4	1.1
Number of incorrect matches in round	0.2	0.3	1.3	-0.2	0.8	0.1	1.1	0.8	-0.1	-0.3	-0.5	0.8	0.1	0.3
Allergy	0.2	0.3	1.7	0.0	-0.4	-1.3	0.4	-0.3	0.3	0.2	-0.4	-0.3	-1.3	-0.0
Peak expiratory flow (PEF)	0.2	0.5	3.1	-0.9	-0.5	-0.4	-1.8	-0.8	-0.8	-0.1	0.4	0.0	-0.1	-0.5
Blood clot in the leg (DVT)	0.2	0.3	1.3	0.0	1.1	0.5	0.5	0.7	-0.4	0.2	0.3	0.5	0.5	0.5
Medication: Amlodipine	0.2	0.3	1.6	0.6	0.3	-0.6	1.3	0.5	-0.0	0.2	0.5	0.5	-0.3	0.9
Arm fat-free mass (right)	0.2	1.0	3.5	1.6	0.4	-0.2	-0.5	-0.2	1.2	1.9	0.1	0.3	1.3	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.7	-0.2	-0.4	-1.3	-0.1	-0.3	0.0	-0.3	-0.1	-0.4	-0.9	-0.1
Arm predicted mass (right)	0.2	1.1	3.7	1.7	0.1	-0.4	-0.9	-0.5	1.4	1.9	0.2	0.1	1.2	1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-0.1	0.6	-0.7	-0.3	-0.9	0.2	0.4	0.5	0.5	-0.9	0.1
Leg fat-free mass (right)	0.2	0.9	2.2	1.2	-0.7	0.1	-1.3	0.5	1.0	1.5	-0.2	0.5	1.3	1.1
Asthma (self-reported)	0.2	0.5	1.6	-0.5	0.6	1.3	-0.2	0.0	-0.5	-0.9	0.9	0.8	-0.3	-0.8
High cholesterol (Self-reported)	0.2	0.3	1.8	0.3	-0.0	-0.1	-0.5	-0.4	-0.2	0.7	1.4	0.5	0.1	0.5
Basal metabolic rate	0.2	1.4	4.8	1.8	-0.1	-0.3	-0.7	-0.0	1.5	2.2	0.1	0.7	1.6	1.6
Diastolic blood pressure, automated reading	0.2	0.5	1.9	0.2	1.1	-1.4	-0.8	-1.2	0.4	0.4	0.3	-0.3	-0.4	-0.0
Cholesterol lowering medication	0.2	0.4	2.7	-0.3	-0.3	0.4	0.2	-0.1	-1.0	-0.4	0.1	1.6	0.1	-0.2
Schizophrenia (2018)	0.1	0.2	0.6	-0.0	0.3	0.7	0.7	0.3	-0.3	0.3	0.3	0.2	0.3	0.8
Breast Cancer	0.1	0.4	2.3	-0.3	0.6	-0.8	-0.4	0.6	-0.1	-0.4	0.4	1.5	-0.2	-0.1
Schizophrenia (2014)	0.1	0.3	1.6	-0.2	1.3	0.5	0.6	0.6	-0.0	0.1	0.0	0.6	0.4	0.6
Blood Red Count	0.1	1.2	3.6	1.3	-1.3	1.9	0.5	-0.0	1.8	1.1	-1.1	-0.6	0.9	0.8
Respiratory disease	0.1	0.3	1.2	-0.1	0.5	0.8	-0.9	-0.4	0.2	-0.1	1.1	0.9	0.1	-0.4
Tanning	0.1	0.8	3.3	-0.5	0.2	1.1	0.9	0.9	-1.3	-0.5	1.8	-0.6	0.6	0.4
Hand grip strength (right)	0.1	0.3	1.0	-0.3	-0.2	0.7	0.5	0.3	-0.3	-0.2	-1.0	-1.0	0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.3	-0.4	0.3	-0.8	0.0	-0.2	-0.7	-0.7	-0.2	0.2	-0.8
Sitting height	0.1	0.9	3.0	-1.0	1.2	-0.7	1.3	-1.7	-0.9	-0.6	-1.1	-0.4	-0.9	-0.6
Trunk fat-free mass	0.1	0.7	2.5	1.0	0.9	-0.2	-0.1	-0.7	0.6	1.6	0.5	0.6	1.1	0.9
Happiness	0.1	0.2	1.1	-0.2	0.4	1.0	-0.3	0.3	-0.2	-0.5	-0.1	0.0	0.4	0.2
Trunk predicted mass	0.1	0.6	2.3	1.0	0.9	-0.2	-0.0	-0.7	0.5	1.5	0.5	0.5	1.1	0.8
Gout (self-reported)	0.1	0.2	0.7	-0.1	-0.6	0.2	0.8	-0.2	0.3	-0.2	0.8	-0.5	-0.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	1.3	-0.1	-0.2	1.2	-0.6	0.2	-0.2	-0.1	0.2	-0.4	0.3	-0.1
Whole body fat-free mass	0.1	0.8	3.2	1.3	0.1	-0.3	-0.6	-0.3	1.0	1.8	0.1	0.4	1.3	1.2
Whole body water mass	0.1	0.8	3.2	1.3	0.2	-0.3	-0.6	-0.4	0.9	1.8	0.1	0.5	1.4	1.1
Leg predicted mass (right)	0.1	0.7	2.0	1.1	-0.6	0.0	-1.4	0.4	0.9	1.4	-0.1	0.6	1.2	0.9
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	0.3	0.5	0.3	-0.6	-0.0	0.3	0.1	-0.1	0.3	-0.3	-0.1
Hair Pigment	0.0	0.5	1.3	0.4	-1.1	1.0	1.1	-0.0	0.3	0.9	-0.4	-0.8	0.3	0.2

Hub : Genes

VIPR2

Models

Trait associations