Hub : Genes

NCAPG2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1500 0.0430 6.6e-07 0.108 0.065 0.094 0.093 0.100 4.5e-13 2.1e-08 1.8e-11 2.3e-11 3.6e-12
2 GTEx Cells EBV-transformed lymphocytes 0.1720 0.0710 3.2e-03 0.070 NA 0.049 NA 0.073 2.7e-03 NA 1.1e-02 NA 2.2e-03
3 GTEx Liver 0.4220 0.1300 9.4e-03 -0.011 NA -0.007 NA -0.004 9.5e-01 NA 5.7e-01 NA 4.5e-01
4 GTEx Lung 0.2225 0.0760 2.1e-04 -0.002 NA 0.050 NA 0.008 5.3e-01 NA 1.1e-04 NA 7.1e-02
5 GTEx Nerve Tibial 0.0911 0.0370 3.2e-03 0.047 NA 0.059 NA 0.048 2.8e-04 NA 5.4e-05 NA 2.5e-04
6 GTEx Thyroid 0.4950 0.1220 3.9e-03 0.018 NA 0.003 NA 0.014 1.4e-02 NA 1.7e-01 NA 2.8e-02
7 GTEx Whole Blood 0.2160 0.0780 1.3e-03 -0.002 NA -0.002 NA -0.003 5.5e-01 NA 6.1e-01 NA 9.1e-01
8 NTR Blood 0.2604 0.0393 0.0e+00 0.108 0.099 0.121 0.116 0.114 7.8e-33 2.4e-30 6.3e-37 2.1e-35 9.8e-35
9 ROSMAP Brain Pre-frontal Cortex 0.0612 0.0270 4.1e-03 -0.002 0.011 0.002 0.013 -0.002 6.2e-01 1.4e-02 1.4e-01 7.1e-03 7.0e-01
10 YFS Blood 0.5172 0.0421 0.0e+00 0.140 0.244 0.272 0.261 0.262 1.5e-43 9.8e-79 2.0e-89 3.7e-85 1.6e-85
11 TCGA Bladder Urothelial Carcinoma 0.0560 0.0320 8.5e-03 0.014 0.004 0.007 NA 0.004 2.1e-02 1.3e-01 8.1e-02 NA 1.4e-01
12 TCGA Pheochromocytoma and Paraganglioma 0.1080 0.0500 8.5e-04 0.024 0.093 0.043 NA 0.040 3.8e-02 1.5e-04 8.2e-03 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.3 0.4 1.6 -0.1 0.1 0.0 0.8 0.7 -0.2 0.0 -0.7 1.2 -0.1 -0.1 1.3
Bipolar Disorder or Schizophrenia 0.6 1.5 4.1 -1.6 -0.5 -0.6 1.2 1.5 -1.5 0.0 -0.2 1.1 1.2 -1.5 2.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 0.8 0.6 0.2 -0.2 0.1 -0.1 0.0 1.2 1.2 0.6 0.2 -0.2
Depression (Nagel 2018) 0.2 0.3 0.8 0.9 0.9 0.8 -0.1 -0.5 -0.8 0.0 -0.2 -0.3 0.2 0.8 0.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.9 -0.1 -0.6 -0.2 0.8 -0.1 0.2 0.0 0.9 0.8 0.8 0.1 0.1
Neuroticism (Nagel 2018) 0.6 1.3 5.3 0.1 1.9 2.3 1.3 1.2 0.3 0.0 0.5 0.9 1.3 -0.5 1.0
Schizophrenia (2018) 0.7 1.5 3.8 -2.0 -0.7 -0.8 0.5 1.4 -1.6 0.0 0.2 0.3 1.6 -1.9 1.6
Schizophrenia vs Biploar Disorder 0.4 0.5 2.6 0.3 -0.5 -0.7 -1.6 -0.9 -0.6 0.0 0.2 -0.5 -0.0 0.3 -1.0
Worry (Nagel 2018) 1.2 2.6 7.3 -0.7 2.1 2.4 2.7 1.6 1.0 0.0 0.3 1.6 1.6 -0.8 2.0
Alzheimer’s Disease (in mother) 0.8 1.0 3.8 0.4 0.9 1.2 0.6 -0.3 -1.6 0.0 -2.0 -1.3 -0.2 0.9 -0.2
Alzheimer’s Disease (in father) 0.4 0.5 1.9 1.1 0.8 0.2 -0.7 -0.8 -0.3 0.0 -1.4 -0.4 -0.7 0.5 -0.1
Alzheimer’s Disease (including proxy) 0.5 0.8 4.1 0.6 0.7 0.3 -0.1 -0.7 -1.4 0.0 -2.0 -0.8 -0.5 0.9 -0.3
Crohns Disease (2017) 0.3 0.7 2.9 0.3 -0.3 0.0 1.4 0.1 1.7 0.0 -1.5 0.2 0.2 -0.2 1.0
Irritable Bowel Disease (IBD) 0.4 0.8 3.7 -0.8 -0.8 -0.1 1.9 0.6 -0.6 0.0 -1.4 0.1 0.1 -0.6 1.4
Ulcerative Colitis (UC) 0.6 1.1 3.8 -1.2 -0.6 0.4 1.9 0.5 -1.9 0.0 -0.8 -0.3 0.1 -0.2 1.6
Major Depression (MDD) 0.3 0.3 1.6 -0.0 1.2 0.7 1.3 0.3 -0.4 0.0 -0.3 0.1 0.1 0.2 0.3
Reaction Time 1.1 2.2 10.6 -1.3 0.8 -0.0 3.2 1.3 -0.1 0.0 0.0 2.5 0.5 0.5 2.3
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.5 1.3 0.1 0.7 -0.6 -1.6 -0.1 0.0 0.8 0.2 0.1 1.2 -0.8
Breast Cancer 0.4 1.1 4.1 1.0 1.9 2.0 0.8 -0.1 0.6 0.0 0.9 -0.5 1.3 0.5 0.3
Ovarian Cancer 0.8 1.0 3.9 0.6 -1.5 -1.2 2.0 -0.6 1.3 0.0 -0.1 1.2 -0.6 0.6 -0.2
Prostate Cancer 0.5 0.7 3.9 0.4 -0.5 0.1 1.7 -0.4 2.0 0.0 -0.4 -0.4 -0.1 0.4 0.2
Age at First Birth 0.9 1.2 4.2 -2.0 -1.4 -1.5 1.2 0.6 -0.3 0.0 -0.5 0.8 0.6 -1.8 0.4
Bipolar Disorder (2011) 2.0 1.9 6.7 -1.7 1.2 1.0 0.8 2.6 0.9 0.0 0.3 1.1 1.1 -1.9 1.7
Body Mass Index (BMI) (2010) 0.6 0.8 4.2 0.2 -2.1 -1.8 -1.0 -0.1 0.6 0.0 -0.3 -0.1 -0.7 -0.6 -0.2
Coronary Artery Disease (CAD) 0.8 1.0 4.2 -0.3 1.0 0.4 0.9 2.0 -0.9 0.0 1.2 -0.9 1.3 -0.3 0.6
Crohns Disease (2012) 0.4 0.6 2.5 -0.4 0.6 0.2 -0.2 1.1 1.1 0.0 0.1 -0.1 1.6 -1.2 0.6
Mean Putamen Volume 0.4 0.5 2.4 -0.5 -0.1 -0.7 0.6 0.4 -0.4 0.0 -1.6 0.1 -0.4 -1.1 -0.4
Fasting Glucose 2.0 2.4 5.7 1.3 -1.2 -1.8 -0.0 -1.5 2.1 0.0 -2.4 0.9 -2.3 1.9 -0.9
HbA1C 0.8 0.9 8.2 0.3 -0.1 -0.2 -0.4 -0.1 2.9 0.0 0.7 0.2 -0.4 -0.1 -1.1
HDL Cholesterol 0.5 0.8 3.4 1.0 1.9 1.9 0.6 -0.2 -0.1 0.0 -0.5 -0.4 -0.8 0.7 0.5
LDL Cholesterol 0.6 0.9 4.1 -1.2 -0.6 -0.3 2.0 0.6 1.2 0.0 0.0 0.2 0.6 -0.8 1.2
Lupus 1.2 1.8 6.6 2.0 1.1 0.6 -0.3 -1.7 -0.7 0.0 -1.9 0.5 -1.3 2.6 -0.6
Neuroticism (2016) 0.4 0.6 1.6 0.4 1.2 1.1 -0.5 0.0 0.6 0.0 1.3 0.2 1.1 -0.7 0.2
Primary Biliary Cirrhosis 0.5 0.7 3.3 0.3 0.5 1.8 0.4 -0.4 1.4 0.0 -0.2 -0.0 0.4 0.7 1.2
Rheumatoid Arthritis 1.8 2.5 8.4 -0.4 2.9 2.6 1.4 1.4 -0.4 0.0 0.3 -1.4 1.7 -0.7 2.1
Schizophrenia (2014) 0.7 1.5 4.1 -1.9 -0.7 -0.7 -0.8 1.2 -1.4 0.0 1.1 -0.1 1.5 -2.0 1.2
Triglycerides 0.3 0.5 1.6 -1.0 -0.5 -0.8 1.3 0.3 0.3 0.0 -0.7 0.4 -0.3 0.4 1.1
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.5 0.5 1.6 1.9 0.2 0.9 -0.5 0.0 0.9 -1.4 0.4 -0.2 1.3
Ulcerative Colitis 0.4 0.5 2.1 -0.4 0.3 0.8 1.4 0.8 0.1 0.0 -0.8 1.3 -0.3 0.3 0.7
Blood Eosinophil Count 0.1 0.5 1.4 0.4 0.5 0.5 0.1 -1.0 1.1 0.0 0.8 0.5 1.2 -0.5 -0.2
Blood Platelet Count 0.6 6.7 52.7 2.7 1.2 1.3 1.8 -0.3 7.3 0.0 -2.8 1.8 -1.3 0.5 0.7
Blood Red Count 0.1 1.3 5.3 -1.0 -1.6 -1.5 -0.8 0.3 2.3 0.0 0.8 -0.6 0.1 -1.0 -1.2
Blood White Count 0.3 2.4 9.8 1.7 -0.4 -1.3 -3.0 -1.9 -0.4 0.0 0.6 0.1 -1.1 0.0 -3.1
Heel T-Score 0.1 0.7 3.3 0.5 1.3 -0.3 0.4 -0.6 -0.9 0.0 0.9 -0.6 0.1 1.8 0.5
BMI 1.1 6.2 19.0 2.2 -2.8 -4.4 -3.8 -2.6 -0.1 0.0 -1.3 -0.1 -2.9 1.6 -3.1
Height 0.4 7.1 22.7 -0.1 4.2 4.8 3.4 2.5 0.8 0.0 -2.3 -1.8 0.6 -0.3 4.2
Waist Hip Ratio (WHR) 1.2 5.3 15.1 3.2 -0.7 -1.3 -2.8 -3.5 -1.5 0.0 -1.2 1.1 -2.2 2.6 -3.9
Systolic Blood Pressure 0.2 1.2 3.0 -0.2 1.1 0.3 0.6 1.2 -1.5 0.0 1.7 0.8 1.7 0.8 1.4
Smoking Status 0.2 0.5 1.5 1.0 0.6 -0.4 -1.0 0.2 0.0 0.0 1.0 0.6 0.3 0.7 -1.2
Allergy or Eczema 1.6 4.1 13.0 2.5 -1.3 0.0 -1.0 -3.6 1.1 0.0 -0.7 0.7 -2.5 2.5 -3.5
Cardiovascular Disease 0.4 1.3 3.8 -1.0 -0.7 -1.5 0.8 0.5 -1.6 0.0 1.5 0.1 1.9 -0.0 1.4
Hypothyroidism (self reported) 0.4 0.9 4.6 -0.5 -0.2 0.1 -1.5 0.2 -2.1 0.0 1.5 -0.6 0.4 -0.4 -1.1
Respiratory disease 1.1 2.4 6.2 2.1 0.0 -0.3 -0.3 -2.4 1.3 0.0 -0.5 1.2 -1.9 2.2 -2.5
Type 2 Diabetes (T2D) (2018) 0.5 0.9 3.1 1.3 -0.3 -0.4 0.1 -0.5 -0.5 0.0 -1.6 0.7 -1.0 1.8 -0.9
Lung FEV1/FVC ratio 0.5 2.6 9.5 -1.7 0.9 0.9 1.6 3.0 0.3 0.0 0.4 0.2 2.1 -0.9 3.1
Lung FVC 0.3 1.6 6.4 1.3 -1.2 -1.1 1.5 -0.1 1.1 0.0 -0.5 2.5 -0.3 2.0 0.2
Neuroticism 0.6 1.5 3.7 0.0 1.1 1.7 1.9 1.3 1.4 0.0 0.3 1.9 1.1 -0.5 1.2
Chronotype (morning person) 0.6 1.5 6.2 0.5 1.6 1.2 1.0 0.4 0.4 0.0 -2.5 -0.7 -1.7 1.4 1.0
Hair Pigment 0.0 1.1 3.6 -1.7 -0.1 0.1 1.1 1.5 0.6 0.0 0.3 -0.3 1.1 -1.9 1.1
Tanning 0.1 1.0 4.5 -0.6 1.1 0.5 2.1 1.0 0.3 0.0 -1.0 0.6 -0.1 0.8 1.7
Hand grip strength (left) 0.2 0.5 1.3 -1.1 0.4 0.1 0.3 0.7 0.9 0.0 -0.9 0.5 0.7 -1.1 1.0
Number of treatments/medications taken 0.2 0.3 1.2 -0.5 -0.5 -0.7 1.1 0.5 -0.4 0.0 -0.0 -0.1 0.8 0.2 0.8
Average weekly spirits intake 0.4 0.5 1.4 -1.1 -0.4 -1.1 1.2 1.0 -0.1 0.0 -0.3 0.4 0.2 -0.8 0.5
Sensitivity / hurt feelings 1.5 2.6 7.8 -0.2 2.0 2.8 2.8 1.8 1.4 0.0 -0.4 -0.2 1.3 -0.4 2.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.8 0.1 1.3 1.0 0.3 0.1 -0.2 0.0 -0.2 -0.1 0.6 0.3 1.2
Hearing difficulty/problems: Yes 0.3 0.5 1.7 0.5 -1.0 -0.5 -0.3 -0.0 1.0 0.0 1.3 0.8 0.1 -0.2 -1.1
Relative age of first facial hair 0.4 0.9 4.7 0.7 -0.7 0.0 -0.5 -0.6 0.4 0.0 2.2 -0.7 -0.6 -0.3 -1.8
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 6.8 1.9 0.3 0.0 0.2 -1.5 0.4 0.0 -1.5 -0.1 -1.9 2.6 -1.4
Ever used hormone-replacement therapy (HRT) 2.3 2.9 7.6 2.3 0.5 -0.1 0.1 -2.5 0.6 0.0 -1.7 0.5 -2.7 2.8 -2.3
Ever had hysterectomy (womb removed) 1.2 1.4 5.8 1.3 -1.0 -1.7 -0.6 -1.8 -0.4 0.0 0.3 0.3 -0.6 0.9 -2.4
Systolic blood pressure, automated reading 0.3 0.8 1.9 0.8 1.4 0.8 -0.0 0.8 -1.3 0.0 1.4 -0.2 1.0 1.2 0.2
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 6.1 -1.6 -1.9 -2.5 1.5 1.2 1.6 0.0 0.2 0.9 0.5 -0.6 -0.0
Angina 1.7 2.3 15.1 0.2 -0.3 -0.7 1.1 -0.3 2.6 0.0 -1.3 3.9 0.1 1.3 0.1
Medication for hormone replacement therapy 2.5 2.8 6.8 1.5 -1.3 -0.6 0.5 -1.8 2.6 0.0 -2.5 -0.3 -2.4 2.0 -1.7
Vitamin and mineral supplements 0.6 0.8 1.7 -0.3 1.2 0.6 1.2 1.3 -1.2 0.0 0.5 0.8 0.8 0.3 1.2
Supplements: Zinc 0.8 0.9 5.3 -0.5 -0.0 0.3 -0.2 0.6 0.5 0.0 2.3 -1.1 1.4 -0.4 0.9
Medication: Co-codamol 0.1 0.1 0.7 0.1 -0.1 -0.2 -0.5 0.1 0.8 0.0 -0.3 0.3 -0.2 0.1 -0.6
Medication: Metformin 0.8 1.1 4.9 1.3 0.9 0.6 1.2 -0.6 0.6 0.0 -1.2 -0.6 -1.2 2.2 -0.5
Diabetes (father) 0.5 0.6 2.1 0.8 -1.1 -0.8 -1.4 -1.2 0.3 0.0 0.7 0.3 -0.1 0.4 -0.7
Diabetes (mother) 0.8 1.0 3.9 -0.2 -1.5 -1.6 -0.1 -0.7 -0.5 0.0 2.0 0.4 1.3 0.2 -0.9
Severe depression (siblings) 0.3 0.4 1.1 0.5 0.4 0.5 0.5 0.1 0.8 0.0 -0.6 1.1 -0.1 1.0 0.5
Pack years adult smoking proportion 1.3 2.0 7.8 1.6 0.6 0.7 0.6 -1.7 1.1 0.0 -2.2 -0.0 -1.9 2.8 -0.1
Impedance of leg (right) 1.0 4.7 23.3 -0.5 4.0 4.8 1.6 1.3 0.3 0.0 1.0 -2.2 1.4 -0.9 1.8
Leg fat-free mass (left) 0.3 1.5 5.2 1.0 -1.4 -2.3 -1.5 -0.7 -0.4 0.0 -1.8 0.7 -1.4 0.9 -0.6
Trunk fat percentage 0.7 2.8 10.4 1.7 -0.8 -1.4 -3.2 -1.5 -1.2 0.0 -1.8 -1.2 -2.5 1.1 -1.6
Hand grip strength (right) 0.1 0.3 1.1 -0.7 -0.0 0.2 0.3 0.3 1.0 0.0 -0.2 0.6 0.6 -0.9 0.8
Townsend deprivation index at recruitment 0.5 0.7 2.3 -0.2 -1.0 -1.5 -0.0 -0.1 1.5 0.0 0.4 0.5 0.2 -0.7 -1.2
Current tobacco smoking 0.3 0.4 1.8 0.6 0.2 0.4 -0.5 -0.3 -1.3 0.0 -0.2 -1.1 0.1 1.2 0.2
Average weekly fortified wine intake 0.8 0.9 3.0 -1.4 -0.1 1.0 1.5 0.8 -0.1 0.0 -0.8 -0.1 0.7 -1.0 1.7
Maternal smoking around birth 1.1 1.6 4.1 0.1 -1.0 -1.4 -0.5 -1.5 -1.6 0.0 -1.0 -1.5 -1.6 1.0 -2.0
Fed-up feelings 0.1 0.2 0.8 0.1 -0.0 -0.3 -0.3 0.1 0.5 0.0 0.7 0.9 0.8 -0.4 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.9 0.8 0.9 0.4 -0.9 -0.2 0.5 0.0 -0.1 0.1 0.3 0.7 -0.1
Relative age voice broke 0.4 0.6 2.9 0.1 -0.3 1.0 0.3 0.4 -0.4 0.0 1.5 -1.7 -0.2 0.2 -0.7
Taking other prescription medications 0.5 0.8 2.8 0.6 0.4 -0.0 0.5 -0.8 -0.9 0.0 -1.7 -0.1 -1.3 1.6 0.2
Age when periods started (menarche) 0.5 1.2 5.5 2.4 0.0 0.9 -0.1 -1.0 -0.2 0.0 -0.0 0.3 -1.3 1.7 -1.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.8 -1.0 -0.7 -0.9 0.4 0.2 -0.5 0.0 0.6 0.0 1.0 -1.4 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.0 -0.4 1.0 -0.1 -0.7 0.0 -0.3 0.0 -0.5 -0.8 -0.4 0.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 3.6 -0.2 -1.4 -0.9 -0.2 -0.3 1.9 0.0 0.4 0.1 0.9 -0.1 -0.4
Qualifications: CSEs or equivalent 0.7 0.9 2.7 1.3 1.0 0.3 -1.6 -1.5 0.7 0.0 0.4 0.0 -0.4 1.0 -1.0
Serious illness, injury or assault to yourself 1.0 1.3 3.8 1.4 1.6 1.3 0.2 -0.7 -2.0 0.0 -0.8 0.0 -0.8 1.8 0.2
High blood pressure 0.8 2.2 11.0 -0.4 0.8 0.1 -0.2 1.3 -3.0 0.0 0.7 -3.3 1.2 -0.5 1.2
Hayfever, allergic rhinitis or eczema 0.6 1.3 5.1 1.1 -0.4 0.5 -0.7 -2.0 1.0 0.0 0.2 -0.1 -1.2 1.3 -2.3
Multivitamins +/- minerals 0.8 1.1 3.1 0.0 -1.8 -1.6 -0.4 -1.3 1.1 0.0 -0.7 0.1 -1.2 -0.0 -1.4
Stomach or abdominal pain in last month 0.3 0.3 0.9 0.3 0.0 -0.7 -0.9 -0.5 -0.6 0.0 0.2 0.8 -0.5 -0.3 -0.9
Supplements: Glucosamine 1.0 1.3 3.3 -1.3 0.8 1.8 0.2 0.9 -0.6 0.0 0.7 -1.1 1.1 -1.6 1.7
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 7.2 1.8 -0.4 0.1 -0.9 -2.5 -1.1 0.0 -1.9 -0.3 -2.7 2.3 -1.8
Medication: Atenolol 0.4 0.5 2.1 0.3 -1.0 -0.4 -0.0 -1.4 1.0 0.0 -0.5 -0.1 -0.9 0.9 -0.1
Medication: Levothyroxine sodium 0.3 0.6 3.1 -0.1 0.5 0.3 -1.1 -0.1 -1.7 0.0 0.1 -0.9 -0.6 0.2 -1.0
Sitting height 0.1 0.8 5.0 0.2 0.9 1.0 -0.4 0.1 -0.1 0.0 -2.2 -1.1 -0.9 -0.0 0.9
Chronic bronchitis/emphysema (father) 0.4 0.5 1.4 0.9 -1.2 -1.0 0.9 0.0 0.1 0.0 -0.1 0.2 -0.7 0.5 -1.1
High blood pressure (mother) 0.3 0.4 1.0 -0.2 0.3 0.3 0.7 0.5 0.5 0.0 1.0 -0.5 1.0 0.3 1.0
Body mass index (BMI) 1.0 4.3 11.4 1.7 -2.4 -3.4 -3.2 -2.1 -1.2 0.0 -1.0 0.2 -2.4 1.6 -2.5
Impedance of leg (left) 0.9 4.1 18.5 -1.0 3.7 4.3 1.3 1.5 0.2 0.0 0.8 -2.1 1.6 -1.3 1.8
Leg predicted mass (left) 0.3 1.5 5.6 1.0 -1.4 -2.4 -1.5 -0.7 -0.4 0.0 -1.7 0.6 -1.4 1.0 -0.7
Trunk fat mass 0.6 2.5 8.3 1.7 -0.7 -1.6 -2.9 -1.3 -1.2 0.0 -1.7 -0.9 -2.4 1.2 -1.4
Waist circumference 1.1 4.1 10.0 2.3 -1.2 -2.1 -3.2 -2.3 -1.8 0.0 -1.5 -0.5 -2.4 1.9 -2.8
Number of incorrect matches in round 0.4 0.7 3.4 -1.1 0.8 1.1 -0.3 0.5 -0.6 0.0 -0.4 -1.8 -0.1 -1.3 0.3
Past tobacco smoking 0.2 0.3 1.0 -0.5 -0.3 0.2 -0.9 -0.0 0.0 0.0 -0.7 -1.0 -0.6 -1.0 -0.1
Alcohol usually taken with meals 0.8 1.2 3.1 -1.6 -0.8 0.2 0.4 1.1 0.9 0.0 1.3 -0.4 1.5 -1.4 1.8
Nervous feelings 0.9 1.7 4.6 -0.1 1.6 2.1 2.0 1.0 1.6 0.0 -0.1 1.8 1.2 -1.1 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 6.7 0.6 -0.3 -0.9 0.6 -1.1 1.1 0.0 -1.6 2.6 -0.4 1.3 0.3
Hearing difficulty/problems with background noise 0.6 1.0 2.9 -1.0 -1.0 -0.2 -0.0 0.6 1.2 0.0 1.6 -1.2 0.7 -1.7 -0.7
Hair/balding pattern: Pattern 2 0.8 1.1 4.4 -0.3 -2.1 -2.0 0.1 -1.3 0.3 0.0 0.7 0.4 -0.9 0.1 -1.0
Had menopause 1.2 1.5 6.1 1.4 -0.7 -0.3 -0.4 -1.1 1.8 0.0 -0.6 1.1 -1.5 1.0 -2.5
Had other major operations 1.0 1.2 3.5 1.4 -0.2 -0.5 -0.4 -1.4 -0.5 0.0 -1.1 1.0 -1.8 1.9 -0.5
Forced vital capacity (FVC) 0.2 0.8 2.4 0.6 0.0 0.2 1.4 0.1 1.5 0.0 -0.8 1.5 0.1 0.5 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.0 -1.0 1.7 0.3 0.4 0.8 0.0 0.0 -0.2 -1.0 -0.1 -0.2 1.4
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.2 -0.8 0.5 0.0 0.6 0.7 -0.4 0.0 1.8 -0.1 1.5 -0.4 1.4
Qualifications: None of the above 0.3 0.7 2.1 -0.5 0.8 0.4 1.2 1.5 0.2 0.0 1.2 -0.0 1.1 -0.9 0.1
Financial difficulties in last 2 years 0.6 0.8 3.4 -1.7 -0.2 -0.2 -1.0 0.5 -0.2 0.0 -0.1 -0.8 1.0 -1.8 0.3
Mouth/teeth dental problems 0.2 0.3 1.2 -0.5 -0.4 0.1 1.1 0.7 0.4 0.0 -0.5 0.3 0.5 0.1 0.4
Heart attack 0.7 0.9 4.2 -1.0 0.4 -0.4 1.6 0.7 1.1 0.0 -0.3 2.0 0.9 0.0 0.5
Allergy 0.3 0.6 2.7 -0.3 0.4 -0.4 0.3 1.6 -0.9 0.0 -0.2 0.1 1.0 -1.0 1.2
Pain all over the body in last month 0.8 0.9 3.5 -0.3 -0.2 0.0 -1.9 -0.8 -0.9 0.0 1.0 -1.3 0.6 -0.8 -1.3
Diabetes (self-reported) 0.6 0.9 2.9 1.3 0.9 1.0 0.5 -0.3 -0.7 0.0 -1.2 -0.5 -1.0 1.7 -0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 4.2 0.5 -1.1 -0.1 -0.6 -2.0 -0.9 0.0 0.1 -1.3 -0.8 0.7 -1.0
Medication: Ramipril 0.7 0.8 3.9 0.3 1.4 1.2 0.6 0.7 -0.7 0.0 -0.3 -2.0 0.3 -0.3 1.1
Medication: Simvastatin 0.3 0.4 1.4 0.5 -0.0 0.4 0.3 -0.0 -0.5 0.0 -1.2 1.1 -0.3 1.1 -0.2
Fluid intelligence score 0.4 0.9 4.2 0.7 -0.9 -0.6 -0.0 -1.9 -0.1 0.0 2.0 0.8 0.1 1.1 -0.3
Illnesses of siblings 0.5 0.7 2.2 -1.5 0.2 -0.6 0.2 0.8 0.9 0.0 1.3 0.3 0.9 -1.1 0.8
Neuroticism score 1.0 2.1 5.2 -0.7 1.0 1.1 2.3 1.7 1.5 0.0 0.7 2.0 1.7 -1.0 2.0
Weight 0.3 1.7 4.8 1.3 -0.8 -1.9 -2.2 -0.9 -1.1 0.0 -1.5 -0.4 -1.8 1.0 -1.0
Impedance of arm (right) 0.5 2.2 5.0 -1.3 2.0 2.2 1.3 1.4 1.4 0.0 0.5 -1.1 1.0 -2.1 1.9
Arm fat percentage (right) 0.6 2.4 8.3 1.2 -1.5 -2.5 -2.9 -1.4 -0.9 0.0 -0.9 -0.4 -2.1 0.9 -1.5
Trunk fat-free mass 0.1 0.4 1.3 0.9 0.2 -0.7 -0.0 0.2 -0.7 0.0 -1.0 0.1 -0.6 1.1 0.6
Hip circumference 0.3 1.2 5.5 0.8 -0.5 -1.4 -2.3 -0.4 -0.9 0.0 -1.0 -1.1 -1.6 0.3 -0.9
Time employed in main current job 0.9 1.0 5.2 -1.4 0.6 0.5 0.2 2.3 0.3 0.0 -0.1 -0.2 0.6 -2.0 0.2
Alcohol intake versus 10 years previously 1.0 1.5 4.7 1.7 -0.4 -0.4 -0.5 -1.3 0.2 0.0 -2.2 -0.4 -2.1 1.8 -0.9
Father’s age at death 0.4 0.6 1.4 -0.8 -1.1 -1.2 1.0 0.6 0.7 0.0 -0.1 0.6 0.1 -0.9 -0.9
Worrier / anxious feelings 1.7 3.3 6.9 -2.0 1.2 1.9 2.3 1.9 1.5 0.0 1.8 0.8 2.6 -1.9 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.0 0.0 -0.5 -0.9 -0.7 -0.8 -0.2 0.0 1.0 0.9 0.8 0.3 -0.2
Falls in the last year 0.2 0.3 2.0 -0.8 -0.0 -0.1 -1.4 -0.3 -0.8 0.0 -0.8 -0.0 -0.1 -0.0 -0.1
Hair/balding pattern: Pattern 3 1.0 1.5 5.6 1.5 2.2 2.4 1.5 0.3 0.7 0.0 -0.9 -0.3 -0.3 0.9 0.4
Number of live births 0.5 0.8 2.3 -0.1 -0.8 -1.2 1.2 -0.4 1.5 0.0 1.2 0.8 0.2 -0.4 -1.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.7 -0.1 0.2 0.3 1.0 0.9 0.8 0.0 -0.1 1.1 0.8 -0.0 1.6
Pulse rate 1.1 1.8 7.3 -1.0 -2.7 -1.4 -1.7 -0.6 -1.6 0.0 1.6 -0.8 0.7 -1.3 -0.7
Happiness 0.6 0.7 2.2 -0.6 -1.4 -1.5 -1.0 -0.5 1.3 0.0 -0.0 0.4 0.4 -0.9 0.0
Noisy workplace 0.5 0.6 2.3 -1.1 -1.4 -1.5 0.7 0.1 0.3 0.0 -0.1 -0.7 0.3 -0.9 -0.1
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.6 0.1 -1.1 -0.9 -0.5 -0.6 -0.3 0.0 0.6 1.2 0.6 0.2 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.5 -0.1 0.1 0.3 0.2 0.3 0.1 0.0 0.3 0.1 0.4 0.5 0.7
Mouth/teeth dental problems: Dentures 0.6 0.9 3.5 1.7 0.4 0.1 0.3 -1.9 -0.3 0.0 0.2 -0.1 -1.2 1.5 -0.9
Asthma 1.0 2.1 4.4 1.5 -0.6 -1.2 0.2 -1.8 1.9 0.0 -0.8 1.7 -1.9 2.1 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.8 0.4 0.0 -0.1 0.0 -0.1 -0.4 0.0 -0.9 -0.1 -0.5 0.6 0.3
Medication: Cholesterol lowering 0.3 0.5 2.3 -0.3 -0.3 -0.5 0.4 -0.1 -1.5 0.0 -1.1 1.0 -0.3 0.7 0.6
Depression (self-reported) 1.1 1.4 5.8 1.7 0.4 -0.0 0.1 -1.1 0.0 0.0 -1.3 0.7 -2.4 2.0 0.0
Medication: Lansoprazole 0.6 0.7 4.4 -0.4 -1.0 -2.1 -0.1 0.6 -0.8 0.0 0.3 0.6 0.9 0.0 -0.3
Prospective memory result 1.3 1.6 5.1 -1.3 -0.5 -0.5 2.2 1.9 2.1 0.0 0.8 0.4 0.8 -1.3 0.6
Lung cancer (father) 0.7 0.8 1.9 1.4 -0.1 -0.2 -0.0 -0.8 -0.6 0.0 -0.8 -1.1 -1.3 1.0 -1.4
Illnesses of mother 0.3 0.4 1.5 0.4 1.2 0.7 -0.8 0.6 0.7 0.0 -0.8 0.2 -0.7 -0.5 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.6 -0.8 -0.6 -0.2 1.2 1.6 0.6 0.0 0.3 1.2 1.0 -0.5 1.9
Pulse wave Arterial Stiffness index 0.9 1.0 2.8 0.1 1.1 1.5 0.7 0.0 0.9 0.0 1.6 -1.5 1.7 -0.1 0.1
Impedance of arm (left) 0.3 1.4 4.3 -1.1 1.5 2.1 1.0 1.0 1.2 0.0 -0.0 -0.6 0.7 -1.8 1.5
Arm fat mass (right) 0.6 2.3 7.5 1.1 -1.5 -2.5 -2.7 -1.2 -1.3 0.0 -0.9 -0.5 -1.8 0.9 -1.4
Trunk predicted mass 0.1 0.4 1.3 0.9 0.2 -0.8 0.0 0.2 -0.7 0.0 -0.9 0.1 -0.6 1.1 0.6
Standing height 0.3 3.1 9.5 -0.6 2.9 2.7 1.7 2.2 0.0 0.0 -1.0 -1.0 1.0 -0.9 3.1
Length of working week for main job 0.7 0.8 3.5 0.4 0.2 0.1 1.9 0.5 1.7 0.0 -0.9 1.1 0.1 0.6 0.5
Exposure to tobacco smoke at home 0.9 1.0 5.7 0.2 -0.4 -1.5 -0.8 -0.7 -1.4 0.0 2.4 0.3 0.6 0.3 -0.4
Breastfed as a baby 0.2 0.3 1.1 -0.6 -1.0 0.1 -0.2 -0.4 -1.0 0.0 0.1 -0.6 -0.3 -0.2 0.3
Tense / ‘highly strung’ 0.7 1.2 3.6 -0.6 1.9 1.7 1.2 1.6 -0.4 0.0 -0.6 0.6 1.1 -0.7 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 7.1 0.8 1.9 1.4 2.7 0.4 2.3 0.0 -0.6 1.5 0.1 1.1 1.6
Hair/balding pattern: Pattern 4 0.4 1.0 3.3 -1.4 -0.8 -1.8 -1.2 0.4 -1.0 0.0 0.6 1.3 0.9 -0.8 -0.1
Birth weight of first child 0.1 0.2 1.0 0.4 -0.9 -0.6 -0.5 -0.2 0.1 0.0 -0.2 0.2 -1.0 0.3 -0.4
Peak expiratory flow (PEF) 0.2 0.4 1.8 0.6 0.1 0.1 0.4 -1.0 0.8 0.0 -0.7 0.5 -0.6 1.3 0.3
Pulse wave reflection index 1.4 1.7 6.9 -0.3 2.6 1.9 0.7 1.3 1.5 0.0 1.1 -1.1 1.4 -0.3 1.2
Ever highly irritable/argumentative for 2 days 0.8 0.9 4.8 0.2 -0.5 -0.7 1.0 -0.2 0.7 0.0 -2.2 0.8 -1.3 1.1 -0.1
Loud music exposure frequency 0.6 0.6 4.0 0.4 -0.5 -1.0 0.2 0.5 2.0 0.0 0.6 0.6 1.0 -0.5 0.2
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.7 1.4 1.0 0.0 -0.8 -0.6 -0.9 0.0 -0.7 1.6 -0.4 1.6 -0.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.9 -0.9 -0.3 -0.5 -0.3 1.1 0.9 0.0 0.1 -0.1 0.3 -1.7 0.5
Blood clot in the leg (DVT) 0.4 0.5 1.6 -0.1 0.7 0.3 0.3 -0.1 -0.3 0.0 -1.3 0.5 -0.9 0.7 1.2
Medication: Paracetamol 0.3 0.4 1.4 0.4 -0.9 -0.5 -1.0 -0.5 0.4 0.0 -1.2 0.6 -0.3 0.0 -0.8
Headache pain in last month 0.6 1.0 4.6 1.0 1.2 0.6 0.3 0.3 0.2 0.0 -1.4 2.1 -0.9 1.3 -0.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 5.5 0.7 0.3 0.5 -0.4 -1.4 2.4 0.0 -0.1 0.7 -0.9 0.4 -1.4
Glaucoma (self-reported) 0.5 0.5 2.0 -0.6 -1.3 -1.4 -1.1 0.1 -0.5 0.0 0.2 0.2 0.3 -0.4 -0.7
Gout (self-reported) 0.4 0.6 2.4 0.2 0.4 -0.6 -1.3 0.0 -1.6 0.0 -0.7 -0.8 -0.8 -0.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.9 -0.5 0.8 1.1 -0.9 0.7 -2.0 0.0 1.0 -1.0 0.2 -0.4 -1.0
Medication: Amlodipine 1.0 1.4 4.2 1.1 0.9 0.4 2.0 0.2 -0.1 0.0 -0.9 -2.0 -0.4 1.3 2.1
Medication: Ventolin 100micrograms inhaler 2.2 2.9 7.8 1.9 -1.5 -1.3 -1.6 -2.5 0.8 0.0 -1.6 -0.0 -2.8 2.2 -1.5
Birth weight 0.7 1.4 5.9 0.0 -1.0 -1.2 -2.4 -0.9 -0.2 0.0 1.7 -0.4 0.2 -1.1 -2.0
Chronic bronchitis/emphysema (mother) 1.1 1.3 6.5 0.6 0.2 1.0 -1.7 -0.9 -2.6 0.0 1.2 -0.7 -0.0 0.4 -1.4
High blood pressure (siblings) 0.9 1.3 4.0 2.0 1.1 0.9 -0.6 -0.5 -1.3 0.0 -1.1 -1.4 -0.9 1.4 -1.0
Forced vital capacity (FVC), Best measure 0.3 0.9 3.1 -0.7 -0.5 -0.2 1.5 1.4 0.9 0.0 -0.1 1.3 0.8 -0.4 1.7
Body fat percentage 0.8 3.3 12.3 1.8 -0.9 -1.6 -3.5 -1.7 -1.2 0.0 -1.5 -1.2 -2.6 1.2 -2.0
Leg fat percentage (right) 0.9 3.2 9.2 2.0 -0.2 -1.0 -3.0 -1.8 -1.4 0.0 -1.1 -1.6 -2.6 1.5 -2.4
Arm fat-free mass (right) 0.2 0.8 1.9 0.9 -0.7 -1.4 -1.0 -0.2 -1.0 0.0 -1.2 0.1 -1.0 1.2 -0.3
Exposure to tobacco smoke outside home 0.4 0.6 1.9 1.4 0.6 0.5 -1.2 -0.7 0.3 0.0 -0.7 0.1 -0.8 1.1 -0.2
Comparative body size at age 10 0.7 2.0 5.2 1.5 -1.8 -2.1 -2.3 -1.4 -1.3 0.0 -0.6 0.2 -1.1 0.6 -1.9
Number of full brothers 0.5 0.7 4.8 -0.3 -0.1 -0.1 -1.3 -0.3 -2.2 0.0 0.3 -0.4 -0.0 0.1 -1.1
Worry too long after embarrassment 0.9 1.5 5.3 -0.9 -0.1 1.4 1.5 0.9 0.5 0.0 1.9 -0.5 2.3 -1.1 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 6.3 -1.5 1.5 1.4 2.5 2.5 0.4 0.0 1.9 -0.4 2.2 -1.5 2.2
Wheeze or whistling in the chest in last year 2.7 4.7 13.6 2.3 -1.2 -1.4 -1.6 -3.7 -0.1 0.0 -2.6 2.5 -2.8 2.5 -2.4
Number of children fathered 0.6 0.6 1.4 -1.2 -0.2 0.9 0.0 1.0 0.1 0.0 0.7 -1.1 1.1 -1.1 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 5.6 -0.4 2.0 2.1 0.8 1.8 0.1 0.0 0.9 -0.5 1.2 -0.3 2.4
Age at first live birth 0.6 1.1 4.1 -2.0 -0.7 0.5 1.6 0.8 -0.6 0.0 -0.9 -0.2 0.1 -1.2 1.5
Pulse wave peak to peak time 0.8 0.9 2.8 0.1 -0.8 -1.3 -0.4 0.1 -0.8 0.0 -1.7 1.5 -1.7 0.2 0.0
Health satisfaction 1.0 1.3 3.6 0.7 -1.7 -1.8 -1.0 -1.5 0.2 0.0 0.5 0.8 -0.6 0.8 -1.9
Shortness of breath walking on level ground 0.9 1.0 4.4 -0.4 -0.8 -1.1 1.5 -0.1 0.4 0.0 2.1 1.0 1.4 0.7 -0.0
Qualifications: College or University degree 0.2 0.6 2.2 -1.1 -1.3 -0.2 -0.6 0.1 0.4 0.0 -0.6 -0.1 0.5 -1.5 1.2
Eye problems/disorders: None of the above 0.7 0.8 2.6 -1.2 0.7 0.4 0.3 1.0 0.8 0.0 1.2 0.2 1.2 -1.6 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.7 0.2 1.3 0.6 0.5 0.4 -1.1 0.0 -0.1 -0.6 0.3 0.6 0.7
Emphysema/chronic bronchitis 0.2 0.2 0.6 -0.5 -0.4 -0.6 -0.6 -0.3 0.3 0.0 0.4 -0.5 0.8 0.1 0.6
Medication for pain relief, constipation, heartburn 1.3 2.1 7.0 -1.3 1.4 1.6 0.8 1.6 -0.7 0.0 2.6 -1.3 1.5 -1.5 1.6
Neck or shoulder pain in last month 1.2 1.7 4.5 1.5 -1.0 -1.2 -1.4 -1.8 0.1 0.0 -0.6 0.4 -1.9 2.1 -1.2
Medication: Blood pressure 0.7 1.3 7.0 -0.2 0.3 -0.3 -0.1 1.8 -2.6 0.0 0.4 -1.6 0.6 -0.3 1.4
Angina (self-reported) 2.0 2.6 17.1 0.5 -0.4 -0.7 1.2 -0.7 2.6 0.0 -1.4 4.1 -0.2 1.6 0.1
Migraine (self-reported) 1.2 1.4 5.7 -1.2 -0.6 -0.7 0.7 1.1 0.5 0.0 1.8 1.4 2.4 -1.4 0.5
Medication: Ibuprofen 0.4 0.5 2.2 0.6 0.7 0.4 0.6 -0.3 -0.7 0.0 -1.5 0.3 -0.6 1.0 0.5
Medication: Allopurinol 0.7 0.9 5.3 0.1 -0.4 -1.5 -1.7 -0.0 -2.3 0.0 0.3 -0.2 -0.3 -0.4 -0.5
Medication: Omeprazole 0.3 0.3 0.9 0.2 0.9 -0.9 0.5 -0.4 -0.5 0.0 0.6 0.6 0.5 0.5 0.7
Medication: Seretide 50 evohaler 0.5 0.6 1.8 0.8 -0.0 0.1 0.5 -0.8 0.6 0.0 -1.3 0.5 -1.1 1.3 -0.2
Mean time to correctly identify matches 0.8 1.4 6.1 -0.5 0.6 0.1 2.5 1.4 -1.3 0.0 0.6 1.4 0.0 0.8 2.0
Heart disease (mother) 0.3 0.4 0.8 0.5 0.5 0.4 0.8 -0.2 0.8 0.0 -0.7 0.7 -0.9 0.7 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.6 0.4 -0.0 -0.5 -0.1 -1.0 -1.0 0.0 0.5 0.1 -0.6 0.4 -1.3
Whole body fat mass 0.7 2.8 9.9 1.6 -1.1 -2.0 -3.1 -1.4 -1.4 0.0 -1.6 -0.8 -2.3 1.1 -1.6
Leg fat mass (right) 0.8 2.9 9.1 1.6 -1.0 -1.8 -3.0 -1.5 -1.3 0.0 -1.4 -0.8 -2.5 1.3 -2.1
Arm predicted mass (right) 0.2 0.8 2.2 1.1 -0.4 -1.1 -1.0 -0.4 -1.1 0.0 -1.2 0.1 -1.1 1.5 -0.4
Pulse rate, automated reading 0.4 1.2 4.1 1.5 -0.9 -0.3 -1.6 -1.4 -1.2 0.0 0.3 -0.4 -0.5 0.6 -2.0
Alcohol intake frequency. 2.1 4.9 13.3 2.8 -1.6 -0.8 -2.5 -3.6 0.2 0.0 -1.2 0.5 -3.1 2.6 -3.2
Comparative height size at age 10 0.5 2.7 8.8 -0.7 2.3 1.8 2.1 1.9 0.1 0.0 -2.0 -1.2 1.1 -0.7 3.0
Number of full sisters 1.2 1.4 4.3 0.7 -1.7 -1.5 -1.5 -1.4 -1.0 0.0 0.1 1.2 -0.6 0.5 -2.1
Suffer from ‘nerves’ 0.5 0.8 3.3 0.2 1.0 1.2 1.5 0.3 0.3 0.0 -1.8 0.6 -0.2 0.1 0.7
Overall health rating 1.4 3.1 9.9 2.4 0.3 -0.6 -0.6 -2.6 -0.0 0.0 -1.8 0.8 -2.3 3.1 -2.0
Chest pain or discomfort 1.1 1.6 6.5 0.2 -1.2 -1.5 1.8 -0.9 0.0 0.0 -1.5 2.5 -0.8 1.2 -0.4
Had major operations 0.8 0.9 3.6 0.6 -0.9 -0.0 -1.3 -1.4 -1.9 0.0 1.0 -0.0 -0.1 0.4 -1.3
Age at last live birth 0.5 0.7 3.0 -1.3 -0.3 0.7 1.0 -0.5 -1.7 0.0 -0.4 0.2 0.3 -0.7 0.9
Family relationship satisfaction 0.5 0.6 2.9 -0.4 -1.0 -1.7 -0.6 -0.4 0.3 0.0 -0.8 1.0 -0.3 -0.3 0.5
Leg pain on walking 0.5 0.6 2.9 0.5 -0.1 -0.6 1.3 -0.4 1.7 0.0 0.4 -0.1 1.0 0.8 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 7.9 0.8 -0.0 0.6 0.6 -0.9 2.8 0.0 -0.4 1.1 -0.4 1.1 -0.2
Commuting to job workplace: Car/motor vehicle 1.3 1.5 4.7 -0.0 2.2 2.0 0.5 1.6 0.3 0.0 -0.6 -1.8 0.2 0.1 1.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.5 -0.4 -1.2 -1.0 -0.4 -0.2 -0.2 0.0 -0.2 0.1 -0.6 -0.5 -0.6
Medication: Aspirin 2.2 2.9 5.6 1.4 -1.5 -1.2 0.4 -2.0 2.2 0.0 -2.3 2.4 -1.6 1.9 -1.8
Supplements: Vitamin C 0.7 0.8 3.1 -0.1 1.6 1.8 -0.9 0.6 0.4 0.0 0.3 -0.9 0.8 -0.7 0.8
Knee pain experienced in last month 0.6 0.9 3.3 0.9 0.6 0.3 -0.7 -1.3 -0.1 0.0 -1.3 0.1 -1.4 1.8 -0.4
Hypertension (Self-reported) 0.8 2.2 10.5 -0.4 1.1 0.3 0.1 1.4 -2.5 0.0 1.0 -3.2 1.4 -0.5 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.2 -0.2 -0.8 -1.4 -0.9 -1.1 -1.4 0.0 0.7 1.5 0.1 0.5 -0.7
Illnesses of father: Heart disease 0.6 0.8 3.0 -1.0 -1.1 -1.2 -0.1 -0.1 1.5 0.0 -0.3 1.7 0.1 -0.6 0.2
Illnesses of siblings: Diabetes 0.8 1.0 4.4 1.1 -0.3 0.3 0.2 -1.3 1.5 0.0 -2.1 -0.1 -1.2 0.6 -0.7
Smoking status: Previous 0.2 0.3 1.3 0.2 0.1 -0.7 0.3 0.5 0.5 0.0 0.9 1.2 0.5 0.2 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.3 -0.8 1.1 -0.0 0.4 0.0 0.3 0.0 -0.4 0.6 1.5 -0.6 1.3
Whole body fat-free mass 0.1 0.9 2.5 1.0 -0.6 -1.6 -0.9 -0.4 -0.7 0.0 -1.5 0.4 -1.1 1.2 -0.1
Leg fat-free mass (right) 0.4 1.9 8.1 0.7 -1.8 -2.9 -1.5 -0.7 -0.3 0.0 -2.0 1.2 -1.4 0.8 -0.6
Arm fat percentage (left) 0.8 3.2 9.9 1.4 -1.8 -2.8 -3.1 -1.7 -0.9 0.0 -1.2 -0.3 -2.5 1.0 -1.9
Average weekly red wine intake 0.8 1.2 3.4 -1.5 0.1 -0.1 0.9 1.4 1.4 0.0 -0.2 1.4 1.0 -1.1 1.8
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.1 0.5 0.8 0.6 -0.5 0.0 1.0 0.0 -0.0 -0.1 0.5 0.8 0.4
Mood swings 0.2 0.4 1.9 0.6 0.5 0.7 0.3 -0.1 1.2 0.0 1.4 0.5 0.4 0.2 0.2
Loneliness, isolation 0.4 0.5 3.0 0.1 -0.8 -0.7 -1.7 -0.1 -1.0 0.0 -0.2 0.7 0.3 -0.3 -0.2
Long-standing illness, disability or infirmity 2.6 4.0 14.6 2.7 -0.1 -0.6 -0.6 -2.9 -0.1 0.0 -1.8 1.0 -3.1 3.8 -1.8
Ever had bowel cancer screening 0.9 1.0 5.1 -0.6 0.4 0.6 1.6 0.8 -2.3 0.0 1.0 -1.3 0.8 -0.1 0.4
Diabetes diagnosed by doctor 0.3 0.5 2.1 0.8 0.2 0.3 0.9 -0.5 -0.3 0.0 -1.2 -0.3 -1.0 1.4 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.0 -0.7 0.3 1.0 -1.0 -0.3 0.7 0.0 0.1 -0.8 0.6 -0.4 -0.0
Friendships satisfaction 0.8 1.0 3.4 -1.3 -0.6 -0.9 0.7 0.5 0.3 0.0 1.8 -0.0 1.8 -1.1 0.9
Qualifications: nursing, teaching 0.5 0.7 2.4 0.5 -0.6 -1.0 0.5 -1.1 0.1 0.0 -1.0 1.6 -0.8 1.3 0.1
Commuting to job workplace: Walk 1.2 1.3 4.1 0.6 -2.0 -1.6 -1.7 -1.6 0.0 0.0 0.6 0.9 -0.6 0.1 -1.2
Eye problems/disorders: Cataract 0.6 0.7 1.8 0.9 0.3 0.3 1.0 -1.0 -1.1 0.0 -1.3 -0.3 -0.4 1.3 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.1 -0.6 -0.2 -0.7 0.0 0.5 -1.0 0.0 0.7 0.3 0.6 -1.0 -0.6
Medication for cholesterol 0.5 0.8 5.4 0.3 0.8 0.9 -1.4 0.3 -2.3 0.0 0.7 -0.5 -0.4 -0.3 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.6 2.1 -1.0 -0.8 -1.2 -0.2 1.4 -0.9 0.0 -0.5 -0.3 -0.0 -0.7 0.9
Back pain experienced in last month 4.0 5.8 14.9 3.6 -0.6 -0.8 -0.2 -3.0 1.8 0.0 -3.7 0.2 -3.6 3.9 -1.4
Mineral and other dietary supplements 0.5 0.7 1.6 0.7 -0.2 -0.6 1.0 0.4 1.2 0.0 -1.3 1.2 0.1 1.2 0.4
Breast cancer (self-reported) 0.3 0.4 1.6 -0.2 -1.3 -0.9 1.0 -0.5 -0.1 0.0 -0.3 0.2 0.6 0.6 -0.5
Asthma (self-reported) 1.1 2.1 4.8 1.6 -0.4 -1.1 0.3 -1.8 1.8 0.0 -0.9 1.9 -1.8 2.2 -1.5
Osteoporosis (self-reported) 0.4 0.5 1.7 -0.4 -1.1 -0.8 0.3 0.0 1.3 0.0 -0.4 -0.8 -0.1 -0.6 -0.7
Osteoarthritis (self-reported) 0.6 0.8 3.6 -1.0 -1.0 -1.0 1.0 -0.2 -0.3 0.0 -1.9 0.2 -0.8 -0.8 0.9
Medication: Aspirin 1.6 2.1 6.8 0.9 -1.1 -1.1 0.5 -1.3 2.1 0.0 -2.6 1.8 -1.2 1.3 -1.2
Medication: Gliclazide 0.4 0.4 1.4 0.4 1.1 0.2 1.2 0.4 1.1 0.0 -0.2 -0.7 -0.3 0.4 0.3
Illnesses of father: None of the above (group 1) 0.4 0.5 2.0 0.4 1.2 1.4 -0.3 0.4 -1.2 0.0 -0.5 -0.6 -0.4 0.1 -0.1
Smoking status: Current 0.2 0.4 2.0 0.5 -0.0 -0.0 -0.2 -0.0 -1.4 0.0 -0.1 -0.6 -0.0 1.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.6 0.6 -0.9 -0.5 -0.2 -0.1 1.0 0.0 -1.5 0.1 -1.6 0.7 -0.2
Whole body water mass 0.1 0.7 2.4 0.9 -0.6 -1.5 -0.7 -0.2 -0.6 0.0 -1.4 0.3 -0.9 1.1 0.1
Leg predicted mass (right) 0.4 1.9 8.5 0.7 -1.8 -2.9 -1.5 -0.7 -0.2 0.0 -1.9 1.2 -1.4 0.8 -0.6
Arm fat mass (left) 0.6 2.4 7.7 1.1 -1.5 -2.4 -2.8 -1.3 -1.2 0.0 -1.1 -0.4 -2.0 1.0 -1.5
Number of self-reported non-cancer illnesses 0.6 1.1 5.1 0.7 -1.0 -0.9 -0.6 -1.6 -0.2 0.0 -0.9 0.1 -1.3 2.3 -0.4
Average weekly champagne plus white wine intake 0.4 0.6 1.5 -0.4 1.1 0.8 1.2 0.9 -0.8 0.0 -0.1 -0.4 0.5 -0.3 1.1
Miserableness 0.3 0.6 2.1 0.5 1.4 0.2 0.5 1.2 0.4 0.0 -1.0 0.2 0.4 0.0 1.0
Guilty feelings 0.8 1.2 3.9 -0.9 1.1 1.5 1.1 2.0 -0.8 0.0 -0.1 0.3 0.7 -0.9 1.6
Wears glasses or contact lenses 1.1 1.2 3.8 -0.6 -1.7 -0.7 -0.7 -0.2 0.1 0.0 1.6 -0.4 1.2 -1.5 -2.0
Ever taken oral contraceptive pill 0.5 0.5 1.6 -0.3 0.8 1.2 -0.1 -0.7 -0.7 0.0 1.1 -1.3 0.5 -0.4 0.3
Hearing aid user 0.8 0.9 3.5 -0.8 -0.8 0.1 1.1 0.4 0.1 0.0 1.9 0.5 1.8 -0.9 0.4
Mother’s age at death 0.4 0.5 1.6 0.9 -0.8 -0.2 -0.5 -0.5 -1.1 0.0 0.7 0.4 -0.2 0.5 -1.3
Financial situation satisfaction 1.0 1.2 3.4 1.7 1.9 1.6 0.1 -0.3 0.7 0.0 -1.1 0.3 -0.5 1.8 0.1
Tinnitus: Yes, now most or all of the time 1.4 1.6 4.2 -1.4 -2.1 -2.0 -0.4 0.6 -1.0 0.0 1.6 1.0 1.1 -1.7 0.1
Commuting to job workplace: Public transport 0.6 0.7 4.1 0.4 0.6 0.5 1.3 -0.2 0.8 0.0 -0.0 2.0 0.9 0.1 0.0
Eye problems/disorders: Glaucoma 0.4 0.4 0.7 -0.8 -0.9 -0.8 -0.5 0.5 -0.6 0.0 -0.2 0.8 0.6 -0.8 -0.9
Medication: Blood pressure 0.3 0.6 2.4 -0.4 1.1 0.5 0.9 0.6 -0.1 0.0 0.6 -0.1 1.3 -0.1 1.6
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.7 0.3 -1.0 -0.2 1.7 -0.3 -0.1 0.0 -0.6 1.6 0.0 1.1 0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.6 -0.4 -0.1 -0.1 -0.2 -0.4 -1.3 0.0 -0.3 -0.8 -0.7 -0.9 -0.8
High cholesterol (Self-reported) 0.6 1.1 5.7 -0.0 -0.2 0.1 1.7 -0.1 0.4 0.0 -0.8 2.4 0.5 1.5 1.3
Medication: Bendroflumethiazide 0.8 1.3 4.6 0.0 2.0 1.4 2.2 0.7 -0.5 0.0 -1.1 -1.0 0.1 0.5 1.1
Medication: Paracetamol 0.3 0.4 1.0 0.6 0.4 0.7 0.5 -0.3 0.9 0.0 -1.0 1.0 0.0 0.7 0.4
Medication: Lisinopril 0.3 0.4 2.4 0.7 -0.3 -1.0 -0.3 0.0 0.0 0.0 0.2 1.6 -0.6 0.1 -0.4
Medication: Atorvastatin 0.9 1.2 4.1 -0.2 -0.7 -1.4 1.3 -1.7 0.3 0.0 -0.8 2.0 -0.1 1.3 -0.1
Illnesses of father: High blood pressure 1.0 1.3 4.3 -0.1 1.9 2.1 0.6 0.4 0.5 0.0 1.3 -1.6 1.2 0.3 1.0
Alcohol drinker status: Never 0.6 0.7 1.8 -0.8 -1.3 -0.8 -1.3 0.5 0.2 0.0 1.3 -0.4 -0.1 -1.1 -0.4
Ever smoked 0.4 0.6 3.4 1.0 0.5 0.6 0.5 -1.1 -0.9 0.0 -0.2 0.6 -0.3 1.9 0.1
Basal metabolic rate 0.2 0.9 2.6 1.0 -0.6 -1.6 -1.2 -0.4 -0.8 0.0 -1.5 0.1 -1.1 1.1 -0.1
Leg fat percentage (left) 0.9 3.3 11.2 1.7 -0.5 -1.4 -3.4 -1.8 -1.3 0.0 -1.2 -1.5 -2.5 1.3 -2.6
Arm fat-free mass (left) 0.1 0.5 1.6 0.6 -0.3 -1.3 -1.0 0.0 -1.2 0.0 -0.7 -0.1 -0.7 0.8 0.1
Number of operations (self-reported) 2.0 2.9 8.8 1.4 -1.7 -1.6 -1.4 -3.0 -2.0 0.0 -0.2 -0.1 -1.8 1.6 -2.7
Average weekly beer plus cider intake 0.4 0.6 1.8 0.4 -1.1 -1.3 -0.1 -0.9 0.5 0.0 -0.2 0.1 -0.9 0.6 -1.4
Irritability 0.5 0.9 3.2 -0.8 0.1 -0.5 -0.1 0.7 0.7 0.0 0.8 1.5 1.6 -1.8 -0.1
Risk taking 1.2 1.8 5.9 1.2 -0.0 0.5 -1.1 -1.7 -1.2 0.0 -1.4 -1.0 -2.4 2.0 -1.0
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.6 -0.0 -0.5 0.1 1.5 -0.2 -1.2 0.0 -1.2 -1.6 -0.6 0.5 0.3
Fractured/broken bones in last 5 years 1.4 1.8 5.0 1.6 -0.2 0.3 -1.9 -0.9 -1.3 0.0 -1.5 1.0 -2.2 1.4 -1.7
Age started oral contraceptive pill 0.1 0.2 0.5 -0.2 -0.2 0.7 0.5 0.6 0.2 0.0 -0.1 -0.3 0.2 -0.4 0.6
Diastolic blood pressure, automated reading 0.3 0.8 3.6 1.0 0.4 0.1 -1.3 0.2 -1.9 0.0 0.8 -0.8 0.1 1.1 -1.0
Ever depressed for a whole week 0.5 0.7 3.4 -0.9 0.4 0.1 1.2 0.9 0.4 0.0 -0.0 -0.1 1.1 -0.4 1.8
Unable to work because of sickness or disability 0.5 0.6 3.8 0.8 2.0 0.6 0.4 0.5 0.6 0.0 -0.2 0.6 -0.3 1.1 0.5
Commuting to job workplace: Cycle 0.9 1.1 4.7 -1.2 -2.2 -2.0 0.9 -0.2 0.9 0.0 0.4 1.0 0.0 0.3 0.2
Myopia 1.1 1.6 5.3 -0.4 0.8 0.8 -0.7 -0.6 -2.3 0.0 1.9 -2.3 1.4 -0.1 0.9
Vascular/heart problems diagnosed by doctor 0.4 1.0 6.1 0.3 0.2 0.7 -0.2 -0.7 1.7 0.0 -0.5 2.5 -1.1 0.2 -0.8
Cholesterol lowering medication 0.7 1.1 4.7 -0.1 -0.5 -0.3 2.2 0.1 1.6 0.0 -1.3 1.7 0.3 0.7 0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.8 0.5 0.3 -1.4 -0.1 -0.8 -0.9 0.0 -0.4 0.9 -0.1 1.1 0.5
Pain experienced in last month 2.1 3.5 7.3 -1.9 1.4 1.4 1.5 2.7 0.8 0.0 2.1 -1.2 2.7 -2.5 2.2
Supplements: Calcium 0.5 0.5 1.1 -1.1 -1.0 -0.7 -0.5 0.5 -0.6 0.0 0.3 -1.0 -0.2 -1.1 0.7
Basal cell carcinoma (self-reported) 0.5 0.6 3.7 -0.2 -0.4 -0.7 1.1 0.2 1.9 0.0 0.9 -0.7 0.4 -0.9 0.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 4.4 -0.8 0.3 -0.3 1.6 0.5 1.3 0.0 -0.3 2.1 0.8 0.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.9 -0.1 0.6 0.3 0.7 -0.2 -0.0 0.0 -1.4 0.6 -0.9 0.8 1.4
Heart disease (siblings) 0.2 0.2 0.6 0.8 -0.5 -0.2 -0.6 -0.6 -0.6 0.0 -0.4 -0.7 -0.1 0.4 -0.1
Alcohol drinker status: Previous 0.9 1.0 2.8 1.6 0.9 1.7 -0.3 -1.3 -0.4 0.0 0.5 -0.7 -0.6 1.7 -0.2
Pack years of smoking 2.0 2.9 11.0 2.2 0.6 0.8 0.2 -2.4 1.0 0.0 -2.2 -0.5 -2.3 3.3 -0.8
Impedance of whole body 0.5 2.4 11.3 -0.9 2.6 3.4 0.9 1.0 1.0 0.0 0.3 -1.3 1.0 -1.5 1.5
Leg fat mass (left) 0.7 2.8 9.8 1.4 -1.1 -2.0 -3.1 -1.4 -1.3 0.0 -1.3 -0.8 -2.2 1.1 -2.0
Arm predicted mass (left) 0.1 0.7 1.7 0.8 -0.4 -1.3 -1.1 -0.0 -1.3 0.0 -1.0 -0.2 -0.9 1.0 0.0