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chr1:91,271,668-95,250,942

Best TWAS P=7.69e-15 · Best GWAS P=4.01e-26 conditioned to 7.43e-18

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CDC7	0.35	0.32	lasso	8	0.37	1.4e-47	6.68	-7.1	1.7e-12	0.05	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DR1	0.21	0.20	blup	305	0.23	1.8e-27	-6.58	-5.4	5.6e-08	-0.03	0.94	0.06	FALSE
3	CommonMind	Brain Pre-frontal Cortex	EVI5	0.03	0.01	blup	335	0.02	1.3e-03	5.45	5.8	7.1e-09	-0.03	0.44	0.03	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TMED5	0.06	0.07	enet	20	0.09	6.7e-11	-6.36	6.4	2.1e-10	0.00	0.20	0.80	FALSE
5	GTEx	Adipose Subcutaneous	CCDC18	0.06	0.00	lasso	6	0.01	2.1e-02	-3.35	5.5	4.2e-08	-0.04	0.09	0.66	FALSE
6	GTEx	Adrenal Gland	SNORD21	0.20	0.09	enet	28	0.11	7.1e-05	5.46	6.8	1.4e-11	-0.05	0.10	0.19	FALSE
7	GTEx	Artery Tibial	EVI5	0.08	0.08	lasso	10	0.12	9.5e-10	5.62	5.7	1.6e-08	-0.04	1.00	0.00	FALSE
8	GTEx	Artery Tibial	DR1	0.17	0.11	lasso	8	0.18	5.9e-14	-6.65	-5.4	6.2e-08	0.01	0.79	0.21	FALSE
9	GTEx	Brain Caudate basal ganglia	EVI5	0.10	0.00	enet	19	0.01	1.7e-01	5.45	5.7	1.2e-08	-0.04	0.12	0.05	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CDC7	0.28	0.18	lasso	3	0.14	2.6e-04	6.51	-7.0	2.5e-12	0.06	0.37	0.04	FALSE
11	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	-6.11	7.0	3.3e-12	-0.01	0.03	0.91	FALSE
12	GTEx	Brain Cerebellum	RP4-717I23.3	0.48	0.53	enet	32	0.57	2.9e-20	-3.29	5.2	2.2e-07	-0.02	0.92	0.08	FALSE
13	GTEx	Brain Cortex	EVI5	0.25	0.33	lasso	13	0.30	4.1e-09	5.45	5.4	6.8e-08	-0.04	0.98	0.00	FALSE
14	GTEx	Brain Cortex	CDC7	0.26	0.12	lasso	8	0.10	1.1e-03	-5.47	-5.2	1.9e-07	0.03	0.10	0.07	FALSE
15	GTEx	Brain Frontal Cortex BA9	CDC7	0.42	0.14	enet	19	0.13	2.8e-04	-6.32	-7.6	4.0e-14	0.06	0.55	0.04	FALSE
16	GTEx	Brain Frontal Cortex BA9	CCDC18	0.12	0.02	enet	26	0.04	3.7e-02	-5.91	7.7	1.4e-14	-0.01	0.04	0.52	FALSE
17	GTEx	Brain Hypothalamus	EVI5	0.16	0.12	lasso	13	0.05	2.1e-02	5.53	5.6	2.0e-08	-0.04	0.14	0.05	FALSE
18	GTEx	Breast Mammary Tissue	EVI5	0.07	0.06	lasso	4	0.07	2.3e-04	5.43	5.3	1.2e-07	-0.04	0.74	0.02	FALSE
19	GTEx	Breast Mammary Tissue (Male)	EVI5	0.17	0.03	lasso	10	0.08	5.9e-03	5.62	5.5	3.9e-08	-0.04	0.08	0.05	FALSE
20	GTEx	Cells Transformed fibroblasts	EVI5	0.18	0.11	enet	28	0.20	5.9e-15	5.11	6.2	7.5e-10	-0.04	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	CDC7	0.21	0.14	enet	26	0.10	2.7e-08	6.68	-7.5	8.5e-14	0.06	1.00	0.00	FALSE
22	GTEx	Cells Transformed fibroblasts	TMED5	0.10	0.11	lasso	3	0.09	4.6e-07	-6.61	5.9	4.8e-09	0.00	0.17	0.83	FALSE
23	GTEx	Cells Transformed fibroblasts	DR1	0.18	0.21	enet	18	0.24	6.0e-18	-3.37	-5.3	1.0e-07	0.00	1.00	0.00	FALSE
24	GTEx	Colon Sigmoid	EVI5	0.13	0.16	lasso	3	0.12	7.0e-05	5.46	5.5	4.8e-08	-0.04	0.78	0.02	FALSE
25	GTEx	Colon Transverse	CCDC18	0.10	0.04	enet	11	0.04	8.0e-03	-5.43	6.2	4.7e-10	-0.02	0.22	0.59	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	EVI5	0.22	0.10	lasso	7	0.06	2.3e-03	4.81	5.6	2.6e-08	-0.04	0.83	0.01	FALSE
27	GTEx	Esophagus Mucosa	EVI5	0.12	0.19	lasso	4	0.19	6.0e-13	4.81	5.4	5.9e-08	-0.04	1.00	0.00	FALSE
28	GTEx	Esophagus Mucosa	CDC7	0.31	0.36	lasso	3	0.36	5.4e-25	6.51	-6.5	7.8e-11	0.06	1.00	0.00	FALSE
29	GTEx	Heart Atrial Appendage	EVI5	0.09	0.06	lasso	7	0.05	4.2e-03	5.45	5.4	6.7e-08	-0.04	0.41	0.03	FALSE
30	GTEx	Heart Left Ventricle	EVI5	0.07	0.11	lasso	5	0.08	7.7e-05	5.46	5.6	2.2e-08	-0.04	0.84	0.01	FALSE
31	GTEx	Lung	EVI5	0.11	0.08	lasso	11	0.13	7.0e-10	5.02	5.6	2.7e-08	-0.03	1.00	0.00	FALSE
32	GTEx	Lung	CDC7	0.15	0.09	lasso	8	0.08	1.2e-06	6.70	-6.8	7.5e-12	0.05	0.99	0.00	FALSE
33	GTEx	Nerve Tibial	EVI5	0.17	0.13	enet	25	0.18	4.5e-13	4.70	5.3	8.9e-08	-0.04	1.00	0.00	FALSE
34	GTEx	Nerve Tibial	CDC7	0.23	0.14	lasso	5	0.14	3.1e-10	-5.47	-6.3	3.4e-10	0.03	1.00	0.00	FALSE
35	GTEx	Nerve Tibial	CCDC18	0.06	0.04	lasso	11	0.04	7.2e-04	-6.36	5.9	4.2e-09	-0.02	0.14	0.70	FALSE
36	GTEx	Nerve Tibial	FAM69A	0.17	0.03	enet	19	0.05	1.4e-04	2.89	-6.0	2.6e-09	0.01	0.80	0.10	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CDC7	0.14	0.16	lasso	3	0.16	7.9e-09	6.51	-6.8	7.4e-12	0.06	0.99	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CDC7	0.31	0.27	enet	36	0.26	1.9e-21	6.51	-7.1	1.2e-12	0.05	1.00	0.00	FALSE
39	GTEx	Spleen	CCDC18	0.29	0.07	lasso	10	0.15	9.2e-05	-6.58	6.9	5.7e-12	-0.01	0.06	0.83	FALSE
40	GTEx	Testis	TMED5	0.27	0.31	lasso	5	0.30	6.9e-14	-6.64	6.6	5.2e-11	0.01	0.39	0.61	FALSE
41	GTEx	Testis	CCDC18	0.13	0.01	lasso	6	0.00	5.5e-01	-5.57	6.5	7.1e-11	-0.02	0.08	0.07	FALSE
42	GTEx	Thyroid	FAM69A	0.43	0.18	enet	41	0.20	5.5e-15	-4.05	-6.9	6.7e-12	0.04	1.00	0.00	FALSE
43	GTEx	Uterus	EVI5	0.23	0.12	enet	27	0.16	4.3e-04	5.45	5.6	2.4e-08	-0.03	0.34	0.06	FALSE
44	GTEx	Vagina	CDC7	0.32	0.12	enet	18	0.17	8.8e-05	-6.74	-7.6	3.3e-14	0.07	0.14	0.09	TRUE
45	GTEx	Whole Blood	EVI5	0.03	0.01	lasso	2	0.01	6.8e-02	5.43	5.8	8.4e-09	-0.03	0.63	0.01	FALSE
46	GTEx	Whole Blood	CDC7	0.11	0.02	enet	19	0.03	3.3e-04	-6.80	-5.2	2.2e-07	0.04	0.58	0.02	FALSE
47	METSIM	Adipose	CDC7	0.17	0.12	enet	46	0.15	1.2e-21	6.68	-6.0	2.2e-09	0.06	1.00	0.00	FALSE
48	NTR	Blood	CCDC18	0.03	0.00	blup	317	0.01	1.1e-05	-6.36	7.8	7.9e-15	-0.08	0.06	0.85	TRUE
49	NTR	Blood	TMED5	0.01	0.01	blup	277	0.01	5.2e-04	-6.36	7.8	7.7e-15	-0.03	0.04	0.93	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	CDC7	0.28	0.25	enet	30	0.29	1.2e-37	6.68	-7.0	3.3e-12	0.05	1.00	0.00	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	DR1	0.09	0.12	enet	20	0.16	1.2e-20	-3.29	-6.1	1.2e-09	0.02	0.09	0.91	FALSE
52	YFS	Blood	CDC7	0.30	0.30	enet	16	0.33	3.3e-110	6.68	-7.2	4.5e-13	0.06	1.00	0.00	FALSE
53	YFS	Blood	DR1	0.11	0.17	lasso	17	0.19	2.0e-58	-6.11	-6.3	2.7e-10	0.00	0.97	0.03	FALSE
54	YFS	Blood	FAM69A	0.28	0.09	enet	29	0.13	4.9e-40	-4.05	-5.9	4.5e-09	0.10	1.00	0.00	FALSE
55	YFS	Blood	TMED5	0.14	0.19	lasso	16	0.22	1.1e-69	-3.33	5.7	1.4e-08	-0.02	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC7	0.13	0.15	blup	73	0.18	7.8e-15	6.70	-7.5	8.1e-14	0.07	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC7	0.07	0.12	enet	13	0.14	1.2e-27	6.68	-6.9	4.5e-12	0.05	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	DR1	0.04	0.04	lasso	3	0.04	1.5e-08	-6.11	-6.5	8.7e-11	0.00	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI5	0.03	0.03	lasso	4	0.04	3.6e-09	4.79	5.5	3.4e-08	-0.04	0.05	0.95	FALSE
60	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CDC7	0.15	0.14	lasso	3	0.11	6.0e-06	6.51	-6.5	6.2e-11	0.06	0.02	0.97	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	CDC7	0.17	0.18	enet	14	0.17	7.8e-10	6.49	-6.5	1.2e-10	0.03	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	DR1	0.36	0.06	enet	9	0.06	2.2e-04	-6.36	-6.1	1.3e-09	0.03	0.02	0.90	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	EVI5	0.07	0.04	blup	93	0.03	4.7e-03	5.01	5.5	2.8e-08	-0.03	0.08	0.61	FALSE
64	The Cancer Genome Atlas	Glioblastoma Multiforme	EVI5	0.14	0.04	blup	93	0.06	8.9e-03	4.27	5.6	1.8e-08	-0.02	0.03	0.69	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	TMED5	0.08	0.05	blup	39	0.03	4.7e-02	-6.58	6.9	5.6e-12	-0.01	0.01	0.73	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABCD3	0.03	0.00	blup	61	0.01	7.5e-03	-5.76	-6.2	4.5e-10	-0.57	0.08	0.11	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC7	0.34	0.32	enet	12	0.32	3.8e-36	6.49	-7.0	2.4e-12	0.05	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DR1	0.03	0.03	lasso	1	0.03	3.2e-04	-6.36	-6.4	2.0e-10	0.02	0.01	0.80	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EVI5	0.08	0.04	blup	96	0.06	8.6e-08	4.70	5.6	2.4e-08	-0.04	0.04	0.96	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABCD3	0.03	0.04	lasso	2	0.03	1.9e-04	8.08	-7.7	1.4e-14	-0.76	0.27	0.45	TRUE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC7	0.19	0.16	enet	13	0.24	2.7e-27	-6.80	-6.6	4.7e-11	0.04	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DR1	0.05	0.05	blup	29	0.06	4.1e-07	-6.61	-6.5	1.1e-10	0.00	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI5	0.07	0.05	blup	96	0.06	2.5e-07	4.79	5.3	1.2e-07	-0.04	0.12	0.87	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ABCD3	0.06	0.00	blup	61	0.01	9.5e-02	7.99	-7.0	2.9e-12	-0.67	0.04	0.49	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EVI5	0.04	0.02	blup	96	0.04	1.4e-03	4.35	5.6	2.4e-08	-0.03	0.04	0.60	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARHGAP29	0.05	0.00	blup	96	0.01	8.0e-03	2.37	-5.3	1.3e-07	-0.18	0.02	0.85	TRUE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC18	0.03	0.03	blup	52	0.03	5.0e-04	-5.49	7.5	5.9e-14	0.01	0.04	0.70	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC7	0.08	0.01	enet	13	0.04	2.1e-05	0.69	-5.8	8.5e-09	0.04	0.01	0.98	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	DR1	0.03	0.03	blup	29	0.03	1.1e-04	-6.14	-6.2	4.8e-10	0.00	0.01	0.98	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI5	0.18	0.16	lasso	7	0.15	2.0e-16	5.45	5.7	1.2e-08	-0.04	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMED5	0.08	0.06	enet	12	0.07	3.5e-08	-6.58	5.4	6.5e-08	0.02	0.40	0.60	FALSE
82	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CDC7	0.07	0.07	enet	3	0.06	1.0e-03	-6.80	-6.8	1.1e-11	0.02	0.00	0.98	FALSE
83	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FNBP1L	0.13	0.02	lasso	3	0.01	1.3e-01	-5.84	-6.9	4.4e-12	0.05	0.01	0.64	TRUE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	CDC7	0.05	0.05	lasso	5	0.04	2.7e-05	6.68	-6.7	1.6e-11	0.06	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	DR1	0.05	0.03	blup	29	0.03	1.3e-04	-6.36	-7.4	1.1e-13	0.00	0.01	0.93	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI5	0.05	0.07	lasso	5	0.07	5.6e-09	4.79	5.5	3.8e-08	-0.04	0.10	0.89	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	F3	0.03	0.01	blup	44	0.02	4.1e-03	8.00	7.2	5.7e-13	0.59	0.01	0.68	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC7	0.07	0.13	enet	8	0.11	3.7e-12	6.51	-6.9	4.1e-12	0.06	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DR1	0.03	0.02	blup	29	0.02	3.2e-03	-6.58	-7.0	2.8e-12	-0.01	0.00	0.96	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI5	0.04	0.04	blup	93	0.03	4.8e-04	4.81	5.9	2.8e-09	-0.03	0.08	0.89	TRUE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CDC7	0.08	0.04	blup	76	0.06	7.2e-05	-5.47	-7.0	3.7e-12	0.04	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EVI5	0.05	0.02	blup	96	0.03	2.3e-03	5.04	5.8	9.0e-09	-0.03	0.07	0.77	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDC7	0.30	0.17	enet	9	0.20	5.8e-09	6.68	-5.6	2.4e-08	0.02	0.00	0.99	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DR1	0.09	0.09	lasso	2	0.07	4.7e-04	-6.11	-6.1	1.0e-09	-0.01	0.01	0.78	FALSE
95	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EVI5	0.10	0.06	blup	94	0.08	2.9e-04	5.47	5.8	5.5e-09	-0.03	0.02	0.96	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC18	0.03	0.02	blup	52	0.02	4.6e-03	-5.58	5.6	2.3e-08	0.02	0.07	0.06	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDC7	0.30	0.27	enet	32	0.30	1.3e-31	-6.80	-6.9	5.6e-12	0.05	0.00	1.00	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	DR1	0.10	0.09	blup	29	0.08	3.9e-09	-6.14	-6.6	3.4e-11	-0.01	0.01	0.99	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI5	0.06	0.10	blup	94	0.10	1.7e-10	5.47	5.9	3.4e-09	-0.04	0.02	0.98	FALSE
100	The Cancer Genome Atlas	Soft Tissue Sarcoma	CDC7	0.11	0.18	lasso	3	0.15	2.4e-09	6.51	-6.6	4.3e-11	0.06	0.02	0.98	FALSE
101	The Cancer Genome Atlas	Soft Tissue Sarcoma	DR1	0.10	0.03	lasso	4	0.06	3.2e-04	-3.25	-5.1	3.0e-07	0.01	0.01	0.97	FALSE
102	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDC7	0.13	0.12	blup	76	0.13	6.8e-10	6.49	-7.1	1.7e-12	0.06	0.02	0.98	FALSE
103	The Cancer Genome Atlas	Stomach Adenocarcinoma	DR1	0.07	0.05	enet	9	0.07	6.2e-06	-6.58	-5.7	1.6e-08	0.00	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMED5	0.05	0.06	lasso	2	0.05	1.4e-04	-7.75	7.7	1.3e-14	-0.03	0.01	0.98	FALSE
105	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CDC7	0.17	0.14	lasso	8	0.14	9.9e-06	-6.08	-7.0	2.3e-12	0.05	0.01	0.99	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	CDC7	0.11	0.08	enet	10	0.09	9.3e-09	6.68	-6.4	1.9e-10	0.04	0.00	1.00	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	DR1	0.16	0.18	blup	29	0.19	4.1e-18	-6.61	-7.4	1.7e-13	0.00	0.00	1.00	FALSE