TWAS hub - ABCD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1990	0.0510	1.0e-05	0.097	NA	0.088	NA	0.092	2.4e-08	NA	1.1e-07	NA	5.9e-08
2	GTEx	Adipose Visceral Omentum	0.2180	0.0750	2.3e-03	0.187	NA	0.176	NA	0.182	5.5e-10	NA	1.8e-09	NA	9.9e-10
3	GTEx	Artery Aorta	0.2240	0.0550	3.6e-05	0.197	NA	0.158	NA	0.171	4.2e-11	NA	4.8e-09	NA	1.0e-09
4	GTEx	Artery Tibial	0.2493	0.0579	9.1e-07	0.089	NA	0.147	NA	0.137	1.8e-07	NA	1.4e-11	NA	6.8e-11
5	GTEx	Colon Sigmoid	0.4960	0.0850	4.5e-07	0.487	NA	0.410	NA	0.475	1.8e-19	NA	8.9e-16	NA	7.6e-19
6	GTEx	Esophagus Gastroesophageal Junction	0.2680	0.0850	1.5e-03	0.170	NA	0.097	NA	0.108	9.7e-07	NA	2.3e-04	NA	1.0e-04
7	GTEx	Esophagus Muscularis	0.4000	0.0620	1.7e-10	0.294	NA	0.349	NA	0.352	3.2e-18	NA	4.7e-22	NA	3.2e-22
8	GTEx	Nerve Tibial	0.2933	0.0583	6.2e-09	0.235	NA	0.225	NA	0.224	1.2e-16	NA	6.1e-16	NA	7.0e-16
9	METSIM	Adipose	0.1283	0.0374	8.4e-06	0.057	0.041	0.057	0.055	0.058	6.6e-09	7.6e-07	5.8e-09	1.3e-08	3.9e-09
10	YFS	Blood	0.0208	0.0094	4.4e-03	0.002	0.007	0.000	0.007	0.001	4.8e-02	1.4e-03	5.2e-01	2.2e-03	1.7e-01
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0295	0.0158	2.1e-03	0.001	0.015	0.003	NA	0.003	2.7e-01	7.4e-03	1.2e-01	NA	1.5e-01
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0273	0.0140	1.1e-03	0.036	0.023	0.024	NA	0.031	6.2e-05	1.0e-03	9.3e-04	NA	1.9e-04
13	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0600	0.0370	3.4e-03	-0.003	0.009	-0.002	NA	-0.004	4.8e-01	9.5e-02	4.4e-01	NA	6.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.9	5.8	9.4	-2.2	-2.4	-2.2	-2.5	-2.3	-2.3	-2.7	-2.6	-2.3	-1.0	3.1	2.5	2.5
Knee pain experienced in last month	4.5	7.0	11.8	-3.4	-3.0	-3.1	-2.5	-3.1	-3.1	-3.1	-2.8	-0.6	-0.1	3.0	1.8	2.4
Financial difficulties in last 2 years	4.0	5.3	9.5	-2.9	-2.7	-3.0	-2.2	-2.8	-2.8	-3.1	-2.6	0.3	-1.4	1.4	1.1	1.5
Medication: Ventolin 100micrograms inhaler	3.9	5.0	7.9	2.2	2.1	2.2	1.6	2.2	2.1	2.2	2.7	0.1	2.4	-2.8	-2.6	-2.7
Supplements: Calcium	3.3	3.7	5.7	-2.4	-2.2	-2.4	-2.0	-2.2	-2.2	-2.4	-2.2	-1.0	0.7	1.5	1.1	1.6
Type 2 Diabetes (T2D) (2012)	3.1	3.5	6.7	1.8	2.0	1.6	1.9	2.0	1.7	1.7	2.1	0.7	1.0	-2.3	-2.6	-2.2
Birth weight	2.9	6.2	8.6	2.9	2.8	2.8	2.4	2.8	2.8	2.9	2.8	-0.1	2.0	-2.1	-2.2	-2.2
Angina	2.8	3.6	5.8	-2.0	-2.2	-2.2	-2.4	-2.1	-2.4	-2.1	-1.9	-1.6	-0.4	1.4	1.4	1.7
Alcohol intake versus 10 years previously	2.8	4.2	6.4	-2.5	-2.1	-2.2	-0.7	-2.2	-2.1	-2.4	-2.4	0.7	-0.8	2.3	2.1	2.4
Heart attack/myocardial infarction (self-reported)	2.6	3.3	4.9	-2.1	-1.9	-2.1	-0.0	-2.1	-1.9	-2.2	-2.2	0.2	-2.1	1.1	2.0	1.9
Ever had hysterectomy (womb removed)	2.5	2.8	6.1	1.1	1.4	1.3	1.5	1.3	1.4	1.8	1.9	1.2	0.3	-2.5	-2.5	-2.5
Respiratory disease	2.4	5.4	12.4	1.6	1.8	1.7	2.1	1.7	2.1	1.5	2.3	-0.5	2.9	-3.2	-3.5	-3.3
Heart attack	2.4	3.0	4.5	-1.9	-1.7	-1.9	0.2	-1.9	-1.7	-2.1	-2.1	0.4	-2.1	1.1	2.1	1.9
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	4.9	1.9	2.0	2.0	1.8	2.0	2.0	2.2	1.8	-0.4	0.1	-1.6	-1.1	-1.5
Fractured/broken bones in last 5 years	2.4	3.1	5.4	2.2	2.1	2.0	1.8	2.1	2.3	2.3	1.9	0.8	0.8	-1.3	-0.5	-1.1
Medication: Omeprazole	2.3	2.8	4.8	-1.9	-1.6	-1.7	-1.2	-1.7	-1.6	-2.1	-1.9	-0.7	-1.0	2.2	1.6	1.8
Mood swings	2.3	4.1	6.3	2.5	2.4	2.4	2.4	2.4	2.5	2.2	2.2	1.0	1.5	-1.4	-1.4	-1.4
Fed-up feelings	2.2	4.0	6.6	2.6	2.2	2.3	1.1	2.2	2.2	2.0	2.4	1.1	1.1	-2.0	-2.0	-1.9
Angina (self-reported)	2.2	2.9	4.8	-1.8	-2.0	-1.9	-2.2	-1.9	-2.2	-1.8	-1.7	-1.9	-0.5	1.0	1.2	1.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.5	-2.0	-1.7	-1.9	-1.4	-1.8	-1.7	-2.1	-1.9	-0.6	-0.3	2.0	1.2	1.6
Depressed Affect (Nagel 2018)	2.0	4.2	7.1	2.7	2.4	2.5	1.5	2.5	2.3	2.2	2.4	0.5	1.6	-1.6	-1.8	-1.6
Waist Hip Ratio (WHR)	2.0	9.0	14.3	3.5	3.7	3.6	3.5	3.7	3.8	3.6	3.3	-0.6	0.1	-2.2	-1.7	-2.2
Asthma (self-reported)	2.0	4.0	10.2	1.4	1.8	1.6	2.2	1.7	2.0	1.4	1.9	-0.1	3.2	-2.1	-2.5	-2.6
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.1	1.7	1.7	1.7	1.0	1.7	1.8	1.4	1.7	-1.0	0.3	-1.4	-1.3	-1.7
Medication for hormone replacement therapy	1.9	2.1	4.3	2.1	1.8	1.9	2.0	1.8	1.9	1.8	1.4	0.1	-0.0	-0.5	-0.2	-0.3
Number of full brothers	1.9	2.3	5.2	1.6	1.7	1.5	2.3	1.6	1.6	1.5	1.3	2.0	-0.1	-1.1	-0.9	-1.5
Neuroticism (2016)	1.8	2.6	4.2	1.7	1.6	1.6	1.3	1.6	1.7	1.8	2.0	0.7	1.6	-1.4	-2.0	-1.7
Prospective memory result	1.8	2.2	4.9	-2.1	-1.8	-1.9	-1.2	-1.9	-1.7	-2.2	-1.6	0.6	0.3	0.8	0.4	0.7
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	4.5	-1.2	-1.4	-1.4	-0.8	-1.4	-1.3	-1.3	-1.7	-2.1	-1.6	1.7	1.8	1.9
Ovarian Cancer	1.7	2.3	4.9	-1.6	-1.8	-1.9	-0.7	-1.9	-1.7	-2.2	-1.9	1.7	0.2	0.5	0.9	1.0
Stomach or abdominal pain in last month	1.7	2.1	4.2	-2.1	-1.6	-1.6	-1.5	-1.6	-1.7	-1.5	-1.3	-1.7	-0.3	1.3	0.3	0.9
Chronic bronchitis/emphysema (father)	1.7	2.0	3.6	-1.9	-1.5	-1.6	-0.7	-1.6	-1.5	-1.7	-1.7	1.0	-1.1	1.3	1.2	1.1
Impedance of leg (left)	1.7	8.2	13.1	3.0	3.0	3.1	2.0	3.1	3.0	3.0	3.1	0.1	2.0	-3.2	-3.3	-3.6
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	6.3	1.0	1.4	1.4	1.4	1.5	1.4	1.4	0.8	2.5	-1.6	-0.0	0.1	-0.5
Hearing aid user	1.7	1.9	2.9	-1.4	-1.5	-1.3	-1.6	-1.5	-1.4	-1.6	-1.7	-0.4	-0.8	1.5	1.7	1.2
Eye problems/disorders: Glaucoma	1.7	2.0	4.2	-1.4	-1.5	-1.4	-1.0	-1.5	-1.5	-1.4	-1.5	-1.0	1.0	2.1	1.0	1.6
Major Depression (MDD)	1.6	1.9	7.2	-0.4	-0.4	-0.4	-0.7	-0.3	-0.3	-0.7	-1.3	-0.7	-2.7	1.9	2.3	2.3
Hearing difficulty/problems: Yes	1.6	2.5	4.7	-2.1	-2.1	-2.2	-1.2	-2.2	-2.0	-2.0	-1.6	-0.5	0.2	1.0	0.1	1.0
Asthma	1.6	3.2	9.9	1.2	1.5	1.3	1.8	1.5	1.8	1.1	1.6	0.1	3.1	-1.9	-2.3	-2.2
Loneliness, isolation	1.6	2.2	3.0	1.7	1.6	1.5	1.6	1.6	1.6	1.7	1.5	-0.3	1.6	-1.5	-1.2	-1.2
Impedance of whole body	1.6	8.0	12.2	3.4	3.3	3.4	2.1	3.5	3.4	3.1	3.0	-0.7	1.5	-2.5	-2.4	-3.0
Mean Putamen Volume	1.5	1.7	4.0	-1.0	-0.8	-0.9	-0.9	-0.7	-0.9	-1.2	-1.4	-0.8	-2.0	1.7	1.9	1.7
Medication: Co-codamol	1.5	1.8	3.4	-1.6	-1.5	-1.6	-1.9	-1.4	-1.4	-1.7	-1.4	1.3	-0.3	0.6	0.7	0.8
Past tobacco smoking	1.5	2.7	5.7	2.4	2.1	2.2	1.8	2.1	1.9	1.9	1.8	0.5	1.3	-0.6	-0.3	-0.5
Miserableness	1.5	2.5	5.0	2.2	2.0	2.1	1.2	2.1	2.0	2.1	1.8	-0.4	-0.3	-0.8	-0.7	-0.6
Birth weight of first child	1.4	2.6	4.0	-1.4	-2.0	-1.9	-1.9	-1.9	-1.9	-1.7	-1.7	-0.8	-1.1	1.0	1.1	1.8
Family relationship satisfaction	1.4	1.7	3.3	1.6	1.5	1.4	1.6	1.5	1.5	1.7	1.2	0.6	1.8	-0.5	-0.3	-0.5
Body Mass Index (BMI) (2010)	1.3	1.8	3.0	1.2	1.6	1.6	1.3	1.6	1.5	1.7	1.5	1.4	0.4	-0.8	-1.0	-1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.7	1.2	0.9	1.1	0.6	0.9	1.0	1.3	1.4	0.6	1.7	-1.9	-1.8	-1.7
Diabetes (father)	1.3	1.6	2.8	-1.2	-1.6	-1.5	-1.5	-1.6	-1.5	-1.7	-1.2	-1.4	0.3	0.5	0.7	1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.1	-1.5	-1.4	-1.3	-1.3	-1.4	-1.4	-1.2	-1.2	-0.9	-1.0	0.7	0.8	0.8
Pulse wave Arterial Stiffness index	1.3	1.5	3.6	1.4	1.2	1.1	0.9	1.2	1.2	1.5	1.4	-1.2	-0.2	-1.9	-1.1	-1.1
Blood clot in the leg (DVT)	1.3	1.7	9.2	0.5	0.6	0.7	0.7	0.6	0.6	0.3	-0.3	0.4	-3.0	1.3	2.2	1.9
Ever taken oral contraceptive pill	1.3	1.4	8.4	0.7	0.5	0.6	-0.7	0.6	0.5	0.8	0.9	-1.1	2.9	-1.0	-1.6	-1.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.7	-1.1	-1.2	-1.3	-0.7	-1.3	-1.1	-1.5	-1.4	-0.3	0.6	1.6	1.4	1.5
Crohns Disease (2017)	1.2	2.6	4.8	-1.3	-1.4	-1.4	-1.4	-1.4	-1.5	-1.6	-1.9	-1.5	0.1	2.0	2.1	2.2
Blood Platelet Count	1.2	13.4	59.3	1.2	0.7	0.9	-1.2	0.9	0.5	1.5	3.4	-0.2	2.9	-6.2	-7.7	-7.0
Impedance of leg (right)	1.2	5.8	10.2	2.5	2.5	2.6	1.6	2.6	2.5	2.5	2.6	-0.1	1.6	-2.7	-2.8	-3.2
Medication: Atenolol	1.2	1.5	3.6	-1.5	-1.4	-1.5	-0.5	-1.5	-1.3	-1.9	-1.3	-1.5	-0.4	0.5	0.4	0.6
Number of incorrect matches in round	1.2	2.0	5.0	1.3	1.4	1.2	1.6	1.3	1.4	1.3	1.6	0.5	0.2	-2.2	-1.6	-1.8
Father’s age at death	1.2	1.6	3.3	1.8	1.6	1.6	1.1	1.7	1.5	1.8	0.8	1.3	-0.0	0.6	0.8	0.4
High blood pressure (siblings)	1.2	1.8	3.3	1.5	1.4	1.5	0.4	1.5	1.4	0.9	1.6	-1.1	0.8	-1.3	-1.4	-1.8
Worry too long after embarrassment	1.2	1.9	4.5	1.8	1.7	1.6	2.1	1.6	1.5	1.5	1.2	0.1	1.8	0.0	-0.2	-0.5
Migraine (self-reported)	1.2	1.5	4.8	-0.7	-0.8	-0.8	-0.6	-0.8	-0.6	-1.1	-1.2	0.7	-1.5	1.6	2.2	1.9
Medication: Seretide 50 evohaler	1.2	1.4	4.4	1.0	1.2	1.0	0.4	1.2	1.2	0.9	1.4	0.0	-0.3	-2.1	-1.2	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.5	1.2	1.2	1.2	1.1	1.2	1.2	1.0	1.5	-0.5	1.2	-1.1	-1.6	-1.1
Mineral and other dietary supplements	1.2	1.7	3.1	1.7	1.7	1.8	1.7	1.7	1.6	1.4	1.1	1.0	-0.6	0.2	0.1	-0.1
Ever smoked	1.2	2.1	3.7	-1.9	-1.7	-1.8	-1.6	-1.7	-1.5	-1.6	-1.5	-0.5	-1.7	0.6	0.6	0.7
Sensitivity / hurt feelings	1.1	1.9	6.0	1.1	1.3	1.2	1.6	1.3	1.3	1.3	1.3	-0.5	2.4	-1.0	-1.2	-1.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	-1.1	-1.5	-1.4	-0.9	-1.5	-1.5	-1.6	-1.6	-0.8	0.5	0.8	1.0	1.1
Supplements: Glucosamine	1.1	1.4	2.2	-1.3	-1.5	-1.3	-1.1	-1.5	-1.3	-1.3	-1.4	-0.7	-0.0	0.7	1.2	1.3
Medication: Levothyroxine sodium	1.1	1.8	4.4	-1.0	-1.2	-1.0	-1.3	-1.1	-1.3	-1.1	-1.1	-2.1	-1.1	1.6	1.1	1.7
Nervous feelings	1.1	2.1	3.4	1.3	1.3	1.3	1.4	1.3	1.3	1.6	1.7	0.3	1.6	-1.6	-1.9	-1.7
Noisy workplace	1.1	1.3	4.4	-1.4	-1.2	-1.2	-0.3	-1.2	-1.2	-1.0	-1.1	-2.1	0.3	0.9	0.9	1.2
Chest pain or discomfort	1.1	1.5	3.1	-1.6	-1.4	-1.5	-1.3	-1.5	-1.4	-1.8	-0.9	-0.2	1.5	0.8	-0.2	0.4
Smoking status: Previous	1.1	1.7	3.7	-1.9	-1.6	-1.8	-1.6	-1.6	-1.4	-1.5	-1.3	-0.4	-0.8	0.3	-0.0	0.1
Myopia	1.1	1.6	5.7	0.8	0.8	0.8	0.1	0.8	0.8	0.8	1.2	0.6	2.4	-1.6	-2.0	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	8.6	0.5	0.6	0.7	0.4	0.6	0.6	0.3	-0.3	0.4	-2.9	1.1	2.0	1.7
Fasting Glucose	1.0	1.2	6.4	0.9	1.1	1.1	1.5	1.0	1.4	0.4	0.7	2.5	0.1	-0.0	-0.1	-0.0
Pain all over the body in last month	1.0	1.1	2.2	-1.5	-1.2	-1.5	-0.1	-1.3	-1.1	-1.4	-0.9	1.0	0.5	-0.7	-0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	-1.1	-1.2	-1.1	-0.9	-1.2	-1.1	-1.0	-0.9	-1.3	1.2	1.4	0.2	0.6
Medication: Cholesterol lowering	1.0	1.6	3.2	-1.1	-0.9	-1.1	-0.7	-0.9	-0.9	-1.4	-1.5	-0.5	-1.6	1.6	1.8	1.8
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.9	-1.7	-1.3	-1.5	-0.4	-1.4	-1.1	-1.4	-1.1	0.3	0.4	0.6	0.2	0.4
Pulse wave peak to peak time	1.0	1.2	3.1	-1.1	-1.0	-0.9	-0.6	-1.0	-1.0	-1.3	-1.2	1.3	0.2	1.8	1.0	1.0
Eye problems/disorders: None of the above	1.0	1.2	7.9	-0.6	-0.9	-0.8	-1.2	-0.8	-1.0	-0.8	-0.7	2.8	-1.2	-0.5	0.4	0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.3	-1.2	-1.0	-1.1	-0.4	-1.0	-1.1	-1.1	-1.2	0.1	-1.1	1.5	1.1	1.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	4.2	0.9	1.2	1.0	1.7	1.1	1.3	1.0	1.3	0.3	0.5	-1.4	-2.1	-1.8
Breast cancer (self-reported)	1.0	1.2	1.8	1.0	1.2	1.3	0.7	1.2	1.2	1.0	1.3	-0.8	0.2	-0.9	-1.4	-1.4
Medication: Gliclazide	1.0	1.1	2.0	-1.2	-1.0	-1.0	-0.8	-1.0	-1.1	-1.1	-1.2	-1.3	0.6	1.4	1.0	0.9
Wears glasses or contact lenses	1.0	1.2	6.1	-0.5	-0.7	-0.7	-1.2	-0.6	-0.8	-0.3	-0.9	-2.5	-1.0	1.1	1.2	1.1
Neuroticism (Nagel 2018)	0.9	2.2	3.8	1.8	1.8	1.7	1.9	1.8	1.7	1.6	1.5	0.9	1.6	-0.6	-0.9	-0.6
Maternal smoking around birth	0.9	1.3	1.9	-1.4	-1.2	-1.1	-1.3	-1.3	-1.1	-1.3	-0.3	1.3	0.3	-1.1	-1.2	-1.1
Fluid intelligence score	0.9	1.8	3.5	1.9	1.7	1.8	1.0	1.7	1.6	1.6	1.1	1.5	-0.9	0.4	0.4	0.2
Neuroticism score	0.9	1.9	2.8	1.6	1.6	1.6	1.7	1.6	1.6	1.5	1.5	0.3	1.6	-0.5	-0.9	-0.7
Headache pain in last month	0.9	1.6	3.0	1.3	1.5	1.4	1.4	1.4	1.4	1.7	1.5	-0.5	-0.5	-1.1	-1.1	-0.9
Glaucoma (self-reported)	0.9	1.0	4.3	-0.8	-0.8	-0.7	-1.0	-0.8	-0.8	-0.7	-0.9	-0.8	0.5	2.1	0.8	1.4
Number of children fathered	0.9	1.0	2.8	-0.2	-0.5	-0.6	-0.4	-0.6	-0.5	-0.8	-0.9	-1.6	-0.8	1.5	1.6	1.7
Shortness of breath walking on level ground	0.9	1.1	3.0	-0.6	-0.8	-0.7	-0.9	-0.9	-0.9	-1.2	-1.1	-1.0	-0.2	1.7	1.2	1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.4	-1.0	-1.2	-1.2	-0.7	-1.1	-1.2	-0.9	-1.1	-1.5	0.8	0.7	0.6	0.7
Osteoporosis (self-reported)	0.9	1.1	2.6	0.9	1.1	1.1	0.9	1.2	1.1	0.8	1.2	0.5	1.6	-0.6	-1.2	-1.1
Commuting to job workplace: Public transport	0.9	1.0	1.7	-1.1	-1.1	-1.2	-1.3	-1.1	-1.0	-0.8	-1.1	1.0	-0.2	0.0	1.2	1.1
LDL Cholesterol	0.8	1.3	2.5	-1.1	-1.3	-1.2	-1.6	-1.2	-1.4	-1.1	-1.3	1.0	-0.6	1.1	1.1	1.0
Schizophrenia (2014)	0.8	1.9	9.6	-1.0	-1.4	-1.3	-1.3	-1.4	-1.2	-1.6	-1.1	-3.1	0.2	0.2	0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.9	0.6	1.0	1.0	0.9	1.0	0.9	0.8	0.3	-0.2	-2.2	0.8	1.2	0.6
Impedance of arm (right)	0.8	3.7	7.9	2.8	2.6	2.7	1.2	2.8	2.7	2.3	1.7	-0.5	0.4	-0.3	-0.2	-0.8
Impedance of arm (left)	0.8	3.8	7.3	2.6	2.5	2.6	1.2	2.7	2.6	2.2	1.9	-1.1	0.4	-1.0	-0.9	-1.5
Loud music exposure frequency	0.8	0.9	1.9	-1.3	-1.1	-1.2	-1.1	-1.2	-1.0	-1.4	-0.9	-0.8	0.0	0.3	0.0	0.1
Average weekly champagne plus white wine intake	0.8	1.1	1.9	1.2	1.1	1.1	0.1	1.2	0.9	1.2	1.4	0.6	1.1	-1.2	-1.0	-1.0
Unable to work because of sickness or disability	0.8	1.1	1.8	-1.3	-0.9	-1.1	-0.6	-1.0	-1.0	-1.3	-1.2	-0.9	-1.3	0.3	1.1	0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.6	1.9	1.5	1.8	0.7	1.7	1.3	1.7	1.0	1.1	-1.1	0.6	0.4	0.3
Age at First Birth	0.7	1.0	2.8	0.9	1.6	1.3	1.1	1.7	1.4	0.9	0.8	-0.4	-0.2	-0.1	0.6	-0.1
Blood White Count	0.7	5.4	9.5	2.4	2.4	2.4	2.7	2.3	2.5	2.5	2.4	1.3	-1.5	-3.1	-1.4	-2.6
Vitamin and mineral supplements	0.7	1.0	2.2	1.4	1.2	1.5	0.5	1.3	1.2	1.3	1.2	-0.2	0.1	-0.3	-0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.8	-0.6	-0.8	-0.7	-1.4	-0.7	-1.0	-0.5	-1.0	-0.9	0.3	1.2	0.9	1.3
Had other major operations	0.7	0.8	6.8	-0.5	-0.1	-0.2	0.5	-0.2	0.0	-0.1	0.1	2.6	-0.5	-0.9	-0.8	-1.2
Qualifications: None of the above	0.7	1.4	3.0	-1.2	-1.4	-1.5	-0.7	-1.4	-1.4	-1.5	-1.3	-0.6	-1.7	0.4	0.3	0.7
Medication: Ramipril	0.7	0.8	3.0	0.6	0.6	0.6	0.1	0.6	0.5	0.2	1.0	0.3	0.0	-1.5	-1.7	-1.7
Illnesses of siblings	0.7	1.0	2.2	-1.0	-0.8	-0.9	0.1	-0.9	-0.7	-0.7	-1.1	1.1	0.8	1.4	1.3	1.5
Depression (self-reported)	0.7	0.9	1.9	-1.0	-0.9	-1.0	-0.8	-0.9	-0.9	-1.2	-1.0	-0.7	-0.7	1.4	0.7	1.0
Medication: Lansoprazole	0.7	0.8	2.5	-0.5	-0.4	-0.3	-0.6	-0.3	-0.2	-0.3	-0.7	-1.4	-1.6	1.1	1.3	1.1
Medication: Amlodipine	0.7	1.0	3.2	-0.8	-0.9	-0.8	-1.4	-0.9	-1.0	-1.1	-1.0	-0.8	-1.8	0.6	0.8	0.8
Heart disease (mother)	0.7	0.8	2.9	1.0	1.0	1.0	0.5	1.0	0.8	0.7	0.6	-1.7	-1.3	-0.2	0.1	-0.5
Leg pain on walking	0.7	0.8	3.3	-0.8	-0.5	-0.5	-0.5	-0.5	-0.6	-1.0	-0.8	0.7	-0.8	1.8	1.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	0.5	0.8	0.7	0.9	0.7	0.7	1.0	0.9	1.3	1.5	-0.9	-0.8	-0.9
Ever had bowel cancer screening	0.7	0.9	2.7	-1.6	-1.2	-1.4	-0.8	-1.3	-1.0	-0.9	-0.8	-0.4	-0.6	-0.1	0.2	0.2
Medication for cholesterol	0.7	1.1	3.3	-0.7	-0.8	-0.9	-0.5	-0.8	-0.9	-0.6	-1.1	-0.5	0.6	1.5	1.6	1.8
Risk taking	0.7	1.0	1.7	0.7	1.1	1.1	1.3	1.1	1.2	1.1	1.2	-0.1	1.1	-0.2	-1.2	-0.5
Schizophrenia (2018)	0.6	1.2	6.2	-0.7	-1.0	-0.9	-1.2	-1.0	-0.9	-1.0	-0.8	-2.5	-0.9	0.5	0.5	0.7
Breast Cancer	0.6	1.4	3.6	1.9	1.3	1.6	1.4	1.4	1.4	1.3	1.0	-0.6	-0.8	-0.8	-0.1	-0.3
Coronary Artery Disease (CAD)	0.6	0.8	3.4	-0.8	-1.0	-0.7	-1.8	-0.9	-1.0	-1.1	-0.7	0.5	-0.6	-0.1	0.2	0.2
HbA1C	0.6	0.7	1.3	-0.7	-0.7	-0.7	-0.0	-0.8	-0.8	-0.5	-0.9	-0.9	-1.2	0.9	0.9	0.9
Average weekly fortified wine intake	0.6	0.7	2.6	0.6	0.4	0.6	-0.1	0.5	0.4	0.4	1.2	0.3	1.2	-0.8	-1.6	-1.1
Relative age voice broke	0.6	1.0	1.9	-0.8	-0.9	-0.8	-1.2	-0.9	-1.1	-0.7	-1.1	0.5	-1.1	0.8	1.4	1.2
Had menopause	0.6	0.7	1.5	-0.9	-1.0	-0.9	-0.9	-1.1	-0.9	-0.6	-0.5	-1.2	-1.2	0.1	0.2	0.3
Allergy	0.6	1.3	3.0	-0.4	-1.1	-0.9	-1.5	-1.0	-1.2	-0.8	-1.2	0.4	-1.0	1.4	1.7	1.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	4.7	0.9	0.5	0.6	-0.0	0.5	0.5	0.3	0.5	-2.2	1.6	-0.3	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.6	0.9	1.5	-1.1	-1.1	-1.2	-0.7	-1.1	-1.1	-0.7	-0.6	-0.9	1.1	-0.8	-0.8	-0.4
Pulse rate	0.6	1.0	1.4	0.9	1.1	1.0	0.6	1.1	1.2	1.1	1.2	-0.1	-0.8	-1.1	-0.9	-1.2
Exposure to tobacco smoke at home	0.6	0.7	1.4	-0.9	-0.8	-1.0	0.1	-0.9	-0.6	-1.2	-0.9	-1.1	-0.9	0.3	0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	1.1	1.3	1.4	0.4	1.3	1.2	1.3	1.1	-0.6	0.5	-0.6	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.9	-0.5	-0.3	-0.4	-0.7	-0.2	-0.3	-0.4	-0.8	-1.0	-0.5	1.3	1.7	1.0
Emphysema/chronic bronchitis	0.6	0.6	1.4	-0.9	-0.8	-0.9	-0.4	-0.9	-0.7	-1.0	-1.0	-1.2	-0.3	0.1	0.6	0.8
Alcohol intake frequency.	0.6	1.5	3.5	-1.0	-1.0	-1.0	0.1	-1.1	-0.9	-1.2	-1.4	0.7	-0.6	1.9	1.7	1.9
Illnesses of father: Heart disease	0.6	0.9	2.7	1.1	1.0	1.0	1.3	1.0	1.2	0.5	0.5	-1.6	0.3	0.6	0.7	0.4
Illnesses of father: None of the above (group 1)	0.6	0.7	2.3	-0.7	-0.9	-0.7	-1.5	-0.8	-1.0	-0.2	-0.1	0.0	0.1	-1.2	-1.2	-0.8
Pack years of smoking	0.6	0.9	2.7	-0.8	-1.0	-1.1	-1.7	-1.0	-1.2	-1.3	-0.8	0.0	-0.7	0.1	0.0	0.1
Bipolar Disorder (2011)	0.5	0.5	1.3	-0.5	-0.4	-0.5	0.7	-0.6	-0.3	-0.7	-0.2	0.9	0.7	-1.1	-1.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.6	0.3	0.6	0.5	0.9	0.5	0.7	0.5	0.5	1.6	1.6	-0.2	-0.4	-0.5
Lung cancer (father)	0.5	0.6	1.3	-0.9	-1.0	-1.0	-0.9	-1.0	-1.0	-1.1	-0.7	-0.1	-0.2	0.2	-0.1	0.1
Illnesses of mother	0.5	0.7	2.0	1.2	0.8	0.9	0.8	0.8	0.8	1.4	0.9	0.9	0.1	-0.5	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	7.7	1.2	1.0	1.2	1.0	1.0	1.0	1.1	0.5	2.8	-0.9	1.0	0.9	0.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	-0.9	-0.9	-0.7	-1.0	-0.9	-0.9	-0.6	-0.8	-1.5	-1.0	1.1	0.9	1.4
Comparative body size at age 10	0.5	1.3	2.7	-1.6	-1.3	-1.5	-0.4	-1.5	-1.2	-1.6	-1.2	-0.4	-0.6	0.5	0.8	0.3
Pulse rate, automated reading	0.5	1.5	3.0	1.3	1.5	1.3	1.4	1.5	1.7	1.1	0.9	1.0	-1.6	-0.7	0.1	-0.4
Diabetes diagnosed by doctor	0.5	0.8	1.2	1.0	1.0	1.0	-0.5	1.1	0.9	1.0	1.1	0.2	0.9	-0.9	-0.5	-0.8
Friendships satisfaction	0.5	0.6	1.1	1.0	1.0	0.9	0.8	1.0	0.9	1.0	0.4	-0.1	0.4	0.6	0.7	0.6
Qualifications: nursing, teaching	0.5	0.8	1.4	0.9	0.9	1.0	0.1	1.0	0.8	1.0	1.1	0.2	0.8	-0.9	-1.2	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	-1.0	-0.9	-0.8	-0.9	-0.8	-0.8	-1.0	-0.5	-1.0	0.3	0.3	-0.4	0.1
Osteoarthritis (self-reported)	0.5	0.7	2.4	-0.3	-0.4	-0.4	-0.8	-0.4	-0.5	-0.8	-0.8	-0.1	-1.0	1.3	1.1	1.5
Bipolar Disorder or Schizophrenia	0.4	1.1	3.6	-0.7	-1.0	-0.8	-1.1	-1.0	-0.8	-1.1	-0.9	-1.9	-1.0	0.8	0.8	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	-0.7	-0.8	-0.9	-0.8	-0.9	-0.9	-1.3	-0.6	-0.5	0.6	0.1	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.4	1.0	1.8	-0.9	-1.0	-1.0	-0.8	-1.1	-1.0	-1.4	-1.3	-0.3	0.9	1.0	1.1	1.2
BMI	0.4	2.1	4.4	-2.1	-1.8	-1.9	-0.5	-1.9	-1.8	-1.8	-1.5	0.3	-1.1	0.8	0.6	1.0
Cardiovascular Disease	0.4	1.5	4.0	0.7	1.0	0.9	0.9	0.9	0.9	0.6	1.3	1.3	-1.2	-1.5	-1.6	-2.0
Lung FVC	0.4	2.0	5.2	-0.8	-1.2	-1.1	-1.5	-1.1	-1.3	-0.9	-1.5	1.0	-0.7	1.8	2.3	2.1
Chronotype (morning person)	0.4	0.9	2.1	1.3	1.0	1.0	0.1	1.1	0.8	1.0	1.2	-0.7	-0.1	-0.7	-1.5	-1.1
Diabetes (mother)	0.4	0.5	2.9	-0.6	-0.4	-0.5	-0.3	-0.4	-0.4	-0.7	-0.6	1.7	-0.6	0.6	0.5	0.3
Trunk fat percentage	0.4	1.4	2.5	1.0	1.2	1.0	0.6	1.2	1.2	1.0	1.2	-1.4	-1.6	-1.5	-1.1	-1.3
Hand grip strength (right)	0.4	1.0	2.8	0.7	0.8	0.7	1.7	0.7	0.8	0.7	0.2	1.5	-1.2	1.1	1.0	0.9
Serious illness, injury or assault to yourself	0.4	0.5	2.3	-0.1	-0.1	-0.1	0.7	-0.2	-0.0	-0.5	-0.5	0.3	-1.1	0.7	1.5	1.2
Body mass index (BMI)	0.4	1.6	3.8	-1.6	-1.4	-1.5	-1.1	-1.5	-1.6	-1.4	-1.1	-0.8	-2.0	0.4	0.4	0.7
Falls in the last year	0.4	0.6	2.9	0.8	0.6	0.6	-0.3	0.7	0.6	0.5	0.7	1.7	1.0	-0.4	-0.6	-0.5
Number of live births	0.4	0.5	1.2	1.1	0.8	0.9	0.6	0.8	0.8	0.8	0.6	-1.0	-0.2	0.4	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	10.4	0.9	0.7	0.8	1.0	0.7	0.7	0.8	0.2	3.2	-0.2	0.7	0.9	0.8
Standing height	0.4	3.7	6.6	2.6	2.4	2.5	2.5	2.4	2.5	2.2	1.2	1.5	0.2	0.4	1.0	0.6
Pulse wave reflection index	0.4	0.4	2.0	0.3	0.2	0.2	0.5	0.2	0.2	0.5	0.7	-0.3	1.4	-1.1	-1.0	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.3	3.9	1.1	0.9	1.1	0.8	0.9	0.8	1.0	0.1	2.0	-1.2	1.3	1.6	1.3
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-1.1	-0.9	-0.9	-0.5	-0.9	-0.8	-0.6	-0.1	0.2	-0.3	-1.0	-1.1	-0.7
Wheeze or whistling in the chest in last year	0.4	0.6	3.5	-0.4	-0.0	-0.2	-0.4	-0.0	0.1	-0.5	0.3	-1.9	1.4	-0.3	-1.1	-0.7
Suffer from ‘nerves’	0.4	0.6	1.7	-0.1	-0.2	-0.3	-0.2	-0.2	-0.2	-0.1	-0.6	-1.0	-1.0	1.2	1.3	1.3
Supplements: Vitamin C	0.4	0.5	1.3	-0.5	-0.8	-0.9	-0.6	-0.9	-0.7	-1.2	-0.8	-0.3	-0.3	0.1	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.7	1.3	1.1	1.2	0.0	1.2	1.0	1.1	0.9	-0.8	0.0	0.1	-0.2	-0.1
Number of self-reported non-cancer illnesses	0.4	0.6	1.4	1.1	1.0	1.2	0.3	1.0	1.1	0.6	0.6	-0.4	-1.0	0.5	0.5	0.4
Mother’s age at death	0.4	0.5	1.0	1.0	0.9	0.9	0.7	1.0	0.9	0.7	0.4	0.1	0.3	0.6	0.5	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.3	0.6	0.6	0.6	1.2	0.5	0.7	0.2	0.4	-1.5	0.8	0.2	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.2	0.4	0.3	0.6	0.4	0.5	0.6	0.7	0.3	0.6	-1.4	-1.1	-1.1
Medication: Paracetamol	0.4	0.6	0.9	-0.5	-0.9	-0.9	-0.9	-0.9	-1.0	-0.9	-0.8	0.2	-0.8	0.3	0.2	0.8
Medication: Atorvastatin	0.4	0.5	3.3	-0.0	-0.2	-0.2	0.1	-0.2	-0.2	-0.4	-0.6	0.4	-1.8	0.6	1.1	0.7
Illnesses of father: High blood pressure	0.4	0.5	2.6	0.2	0.5	0.4	1.6	0.4	0.6	0.5	0.3	0.5	1.4	-0.0	0.1	0.1
Ever depressed for a whole week	0.4	0.5	3.8	-0.1	-0.2	-0.1	-0.3	-0.3	-0.3	-0.1	-0.3	1.2	-1.9	0.3	0.5	0.4
Crohns Disease (2012)	0.3	0.5	2.2	0.6	0.2	0.2	-0.2	0.3	0.2	-0.0	-0.4	-1.5	-0.2	0.6	1.4	1.2
Triglycerides	0.3	0.4	0.8	0.9	0.7	0.7	0.0	0.7	0.6	0.7	0.7	0.4	-0.3	-0.8	-0.8	-0.7
Systolic Blood Pressure	0.3	1.6	4.0	0.9	1.3	1.1	0.5	1.3	1.4	0.5	1.4	1.2	-0.2	-1.6	-1.6	-2.0
Hand grip strength (left)	0.3	0.7	2.3	0.2	-0.1	-0.0	0.5	-0.1	-0.1	-0.0	-0.5	1.1	-1.4	1.5	1.2	1.3
Average weekly spirits intake	0.3	0.3	2.2	0.8	0.4	0.6	0.4	0.4	0.5	0.3	0.3	-1.5	-0.5	-0.0	0.2	-0.0
Severe depression (siblings)	0.3	0.3	1.5	0.1	0.1	0.2	0.2	0.1	0.2	0.1	0.5	-1.2	0.5	-0.9	-0.8	-0.8
Pack years adult smoking proportion	0.3	0.5	1.8	-0.4	-0.7	-0.8	-1.3	-0.7	-0.9	-1.0	-0.5	0.3	-0.5	-0.1	-0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-0.9	-1.1	-1.0	-0.3	-1.2	-1.0	-1.0	-0.9	1.1	-0.1	0.3	0.3	0.5
Sitting height	0.3	1.8	5.3	1.5	1.5	1.4	2.3	1.4	1.7	1.3	1.0	1.9	0.8	-0.2	-0.2	-0.2
Alcohol usually taken with meals	0.3	0.5	1.9	0.2	0.1	0.2	0.7	0.1	0.2	0.0	-0.4	0.8	-0.7	1.1	1.4	1.1
Forced vital capacity (FVC)	0.3	1.1	8.1	0.5	0.4	0.4	0.8	0.3	0.4	0.4	-0.3	2.9	-0.3	0.9	1.4	1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.8	-0.6	-0.6	-1.1	-0.5	-0.7	-0.5	-0.8	0.3	1.6	0.8	0.8	0.7
Length of working week for main job	0.3	0.3	0.8	0.7	0.6	0.6	0.2	0.7	0.6	0.5	0.6	0.9	0.2	-0.4	-0.4	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	4.1	-0.3	-0.4	-0.2	-0.1	-0.4	-0.5	-0.1	-0.2	-2.0	-0.1	0.1	-0.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.1	0.0	0.0	0.2	0.0	0.0	-0.2	-0.3	-1.1	-1.4	0.9	0.9	0.7
Qualifications: College or University degree	0.3	1.0	3.1	-0.6	-0.6	-0.4	-1.0	-0.5	-0.6	-0.3	-0.7	1.8	0.2	1.8	1.4	1.4
Neck or shoulder pain in last month	0.3	0.5	2.2	-0.5	-0.7	-0.7	-0.6	-0.7	-0.6	-0.9	-0.4	-1.5	-0.4	0.3	0.1	0.6
Medication: Ibuprofen	0.3	0.4	2.0	0.2	0.4	0.3	0.3	0.3	0.4	0.1	0.4	1.4	1.1	-0.2	-0.6	-0.6
Medication: Allopurinol	0.3	0.4	1.3	-0.6	-0.4	-0.5	-1.1	-0.3	-0.3	-0.6	-0.5	0.7	-1.0	0.4	0.7	0.3
Number of full sisters	0.3	0.4	3.8	-0.0	0.2	0.3	-0.1	0.2	0.1	0.1	0.4	0.8	-1.9	0.3	-0.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	-0.6	-0.5	-0.5	-0.9	-0.4	-0.5	-0.8	-0.4	0.0	-0.4	1.1	-0.0	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.6	-0.3	-0.4	-0.3	-1.3	-0.3	-0.6	-0.4	-0.2	-1.0	-0.8	0.0	-0.6	-0.2
Medication: Aspirin	0.3	0.4	1.7	-0.5	-0.6	-0.5	-0.5	-0.6	-0.7	-0.6	-0.3	1.3	0.1	-0.4	-0.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-1.0	-0.8	-0.7	-0.2	-0.8	-0.9	-0.7	-0.8	0.1	-0.1	0.5	0.2	0.4
High cholesterol (Self-reported)	0.3	0.5	2.5	-0.7	-0.5	-0.5	-1.4	-0.4	-0.7	-0.6	-0.3	0.2	-1.6	0.2	0.1	0.0
Age started oral contraceptive pill	0.3	0.4	1.9	-0.2	-0.3	-0.3	-0.4	-0.3	-0.2	-0.3	0.2	0.9	1.0	-0.1	-1.4	-0.7
Diastolic blood pressure, automated reading	0.3	1.0	2.8	0.3	0.9	0.7	0.6	0.9	1.0	0.4	0.9	0.3	-1.7	-1.5	-1.0	-1.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	1.0	0.9	1.0	0.7	1.0	0.9	1.3	0.5	-0.3	1.5	0.7	0.5	0.7
Cholesterol lowering medication	0.3	0.5	1.2	-0.6	-0.3	-0.3	-1.1	-0.3	-0.4	-0.3	0.3	0.7	-1.1	-0.6	-1.0	-0.9
Pain experienced in last month	0.3	0.4	1.3	1.1	0.8	0.9	-0.5	0.9	0.6	0.7	0.4	0.3	-0.7	0.0	0.4	-0.2
Heart disease (siblings)	0.3	0.4	0.9	-0.7	-0.7	-0.7	-0.4	-0.7	-0.7	-0.6	-0.6	0.9	-0.8	0.6	0.1	0.4
Alcohol drinker status: Previous	0.3	0.4	3.8	-0.3	-0.4	-0.4	-0.0	-0.4	-0.3	-0.1	-0.3	-0.3	2.0	-0.2	0.1	0.1
Depression (Nagel 2018)	0.2	0.2	0.5	-0.3	-0.6	-0.6	-0.1	-0.6	-0.6	-0.7	-0.6	-0.5	0.4	-0.0	0.4	0.5
Alzheimer’s Disease (in mother)	0.2	0.3	1.5	-0.8	-0.2	-0.3	0.4	-0.3	-0.1	-0.6	-0.2	0.7	-1.2	0.5	0.2	0.5
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.7	0.4	0.4	-0.2	0.5	0.5	0.4	0.0	-1.1	-0.4	-0.0	0.5	0.3
Ulcerative Colitis (UC)	0.2	0.4	2.6	-0.4	-0.5	-0.5	0.0	-0.6	-0.3	-0.7	-0.3	0.9	1.6	-0.4	-0.4	-0.2
Prostate Cancer	0.2	0.3	0.9	0.6	0.4	0.3	0.4	0.4	0.3	0.2	0.6	-0.8	0.9	-0.4	-0.9	-0.6
HDL Cholesterol	0.2	0.3	1.2	0.5	0.3	0.4	0.2	0.3	0.3	0.8	0.5	0.9	-0.7	-1.1	-0.2	-0.7
Lupus	0.2	0.3	1.5	0.0	0.2	0.2	0.4	0.2	0.2	-0.1	-0.3	-0.6	-0.5	1.2	0.7	0.8
Ulcerative Colitis	0.2	0.2	1.3	0.3	-0.0	0.1	0.3	-0.1	0.1	-0.4	-0.0	1.1	1.1	-0.2	-0.0	0.0
Blood Eosinophil Count	0.2	1.4	3.1	1.6	1.3	1.2	1.5	1.2	1.4	1.6	1.1	0.0	-1.8	-0.5	0.4	-0.2
Allergy or Eczema	0.2	0.5	1.9	-0.3	0.3	-0.0	0.4	0.2	0.3	0.0	0.6	-0.7	0.9	-1.0	-1.4	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.6	0.3	0.4	0.5	-0.6	0.5	0.5	0.5	0.6	0.4	1.3	-0.6	-0.2	-0.4
Neuroticism	0.2	0.5	1.6	0.8	0.7	0.7	0.9	0.7	0.8	0.7	0.7	0.9	1.3	-0.2	-0.5	-0.1
Relative age of first facial hair	0.2	0.4	1.8	0.1	-0.1	0.0	-0.0	-0.1	-0.3	0.4	-0.4	0.9	-1.3	0.2	1.1	1.1
Supplements: Zinc	0.2	0.2	2.2	-0.3	-0.3	-0.2	0.3	-0.3	-0.1	-0.1	-0.3	0.0	1.5	0.2	-0.1	0.2
Medication: Metformin	0.2	0.2	0.8	-0.0	0.5	0.3	0.1	0.5	0.5	0.6	0.5	-0.9	-0.4	-0.5	-0.1	-0.6
Leg fat-free mass (left)	0.2	1.1	3.5	-0.6	-0.4	-0.5	0.3	-0.5	-0.4	-0.5	-0.9	1.1	-1.5	1.5	1.8	1.9
Current tobacco smoking	0.2	0.3	2.6	0.1	-0.1	-0.2	0.1	-0.1	0.0	-0.1	-0.4	0.6	-1.6	-0.3	0.9	0.6
High blood pressure	0.2	0.5	1.1	-0.8	-0.6	-0.6	-0.5	-0.7	-0.5	-1.0	-0.1	0.3	-0.7	-0.7	-1.0	-1.1
Multivitamins +/- minerals	0.2	0.3	0.5	-0.6	-0.6	-0.7	-0.3	-0.6	-0.6	-0.5	-0.4	0.4	-0.6	-0.4	-0.1	-0.3
High blood pressure (mother)	0.2	0.2	1.0	-0.2	-0.1	-0.2	-0.6	-0.1	-0.2	-0.6	-0.4	-0.6	-0.1	1.0	0.7	0.4
Leg predicted mass (left)	0.2	1.1	3.5	-0.5	-0.3	-0.4	0.4	-0.4	-0.4	-0.5	-0.8	1.1	-1.5	1.5	1.8	1.9
Trunk fat mass	0.2	0.7	2.8	0.6	0.8	0.6	0.5	0.7	0.7	0.6	0.8	-0.8	-1.7	-1.0	-0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.8	-0.5	-0.5	-0.7	0.2	-0.5	-0.4	-0.7	-0.9	0.4	0.4	0.8	0.9	0.8
Hearing difficulty/problems with background noise	0.2	0.4	2.4	-0.2	-0.2	-0.2	0.3	-0.2	-0.0	-0.1	-0.1	-0.9	1.5	0.7	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	4.3	-0.4	-0.5	-0.4	0.4	-0.6	-0.4	-0.4	-0.3	2.1	-0.1	0.1	-0.1	-0.1
Mouth/teeth dental problems	0.2	0.3	0.9	-0.5	-0.7	-0.4	-0.9	-0.6	-0.8	-0.1	-0.3	0.4	0.1	0.8	0.5	0.7
Diabetes (self-reported)	0.2	0.3	0.6	0.5	0.6	0.6	-0.7	0.7	0.5	0.6	0.7	0.0	-0.2	-0.8	-0.1	-0.4
Medication: Simvastatin	0.2	0.3	3.3	-0.1	0.2	0.0	-0.7	0.2	0.1	-0.2	-0.1	-0.0	-1.8	0.6	0.4	0.3
Trunk fat-free mass	0.2	1.3	4.0	-0.5	-0.5	-0.4	0.6	-0.6	-0.5	-0.3	-0.9	1.5	-1.4	1.6	2.0	2.0
Time employed in main current job	0.2	0.2	0.8	0.1	-0.1	-0.2	-0.2	-0.1	-0.2	-0.1	-0.4	-0.1	0.5	0.9	0.4	0.9
Worrier / anxious feelings	0.2	0.3	1.4	0.2	0.2	0.1	0.6	0.1	0.2	0.0	-0.3	-0.3	0.5	1.1	0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	0.9	0.4	0.5	-0.1	0.5	0.4	0.3	0.5	-1.0	0.5	0.4	-0.3	0.2
Happiness	0.2	0.2	0.7	0.5	0.4	0.3	0.7	0.3	0.5	0.4	0.3	0.8	0.7	-0.2	-0.3	-0.2
Trunk predicted mass	0.2	1.3	4.0	-0.5	-0.6	-0.5	0.5	-0.7	-0.6	-0.3	-0.9	1.5	-1.4	1.6	2.0	2.0
Breastfed as a baby	0.2	0.3	0.8	0.3	0.5	0.5	0.7	0.4	0.5	0.6	0.4	0.3	0.4	-0.9	-0.5	-0.8
Tense / ‘highly strung’	0.2	0.3	1.9	-0.6	-0.4	-0.6	0.1	-0.4	-0.3	-0.4	-0.3	-1.4	0.2	-0.1	-0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.1	0.1	0.0	-0.0	0.1	0.2	-0.0	0.3	-1.0	-0.8	-0.5	-0.9	-0.6
Medication: Paracetamol	0.2	0.3	0.6	-0.4	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	-0.5	0.1	-0.4	0.4	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	0.2	0.2	0.4	0.2	0.3	0.3	0.9	0.5	0.5	1.1	-0.4	-0.4	-0.4
Body fat percentage	0.2	0.8	2.5	0.4	0.6	0.5	0.1	0.6	0.5	0.4	0.8	-1.6	-1.6	-1.3	-1.0	-1.0
Leg fat percentage (right)	0.2	0.6	2.6	-0.9	-0.7	-0.7	-0.6	-0.7	-0.7	-0.6	-0.1	-0.9	-1.6	-0.7	-0.7	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	3.2	0.3	0.2	0.2	0.2	0.2	0.3	0.3	-0.0	-1.8	-0.2	0.1	0.7	0.2
Comparative height size at age 10	0.2	1.1	2.7	1.1	1.2	1.1	1.3	1.2	1.4	0.8	0.3	1.6	-0.6	0.4	0.8	0.5
Whole body fat-free mass	0.2	1.2	3.6	-0.5	-0.5	-0.5	0.6	-0.6	-0.5	-0.4	-0.8	1.5	-1.3	1.5	1.8	1.9
Leg fat-free mass (right)	0.2	1.1	3.8	-0.5	-0.4	-0.5	0.3	-0.5	-0.4	-0.5	-0.9	1.1	-1.3	1.5	1.8	2.0
Average weekly red wine intake	0.2	0.2	1.5	-0.2	-0.1	-0.0	0.0	-0.1	-0.1	0.1	-0.4	1.2	-0.4	0.4	1.0	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.1	0.5	0.4	0.5	0.4	0.5	0.6	0.5	-0.1	0.1	-0.6	-0.5	-0.8
Back pain experienced in last month	0.2	0.3	0.7	-0.8	-0.7	-0.6	0.1	-0.8	-0.7	-0.6	-0.3	-0.1	0.4	-0.2	-0.5	0.1
Smoking status: Current	0.2	0.3	2.1	-0.1	-0.3	-0.4	0.0	-0.3	-0.2	-0.3	-0.6	0.4	-1.4	-0.1	0.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.5	-0.1	-0.1	-0.1	-0.5	-0.1	-0.1	0.1	-0.2	1.2	-0.8	0.3	0.8	0.9
Whole body water mass	0.2	1.3	4.0	-0.6	-0.6	-0.6	0.5	-0.7	-0.6	-0.5	-0.9	1.4	-1.4	1.6	1.9	2.0
Leg predicted mass (right)	0.2	1.1	3.8	-0.5	-0.4	-0.5	0.3	-0.5	-0.4	-0.5	-0.9	1.1	-1.3	1.5	1.8	1.9
Financial situation satisfaction	0.2	0.2	1.1	-0.2	-0.4	-0.4	-1.1	-0.3	-0.5	-0.5	-0.4	0.2	-0.4	0.5	0.5	0.5
Medication: Blood pressure	0.2	0.5	1.4	-0.9	-0.5	-0.4	-0.4	-0.6	-0.3	-0.7	0.1	0.4	-0.5	-0.6	-1.2	-1.2
Medication: Bendroflumethiazide	0.2	0.2	0.7	-0.7	-0.4	-0.5	-0.2	-0.5	-0.4	-0.9	-0.6	0.2	-0.5	0.1	-0.0	-0.5
Basal metabolic rate	0.2	0.9	2.7	-0.5	-0.4	-0.4	0.5	-0.5	-0.4	-0.4	-0.7	1.2	-1.4	1.2	1.6	1.6
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.6	-0.6	-0.6	-0.5	-0.6	-0.5	-0.4	-0.4	0.2	-0.9	0.0	0.3	0.5
Commuting to job workplace: Cycle	0.2	0.2	1.4	-0.2	-0.3	-0.4	-0.1	-0.3	-0.2	-0.5	-0.2	-0.7	1.2	-0.1	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.8	-0.7	-0.7	-0.6	-0.7	-0.4	-0.6	-0.6	-0.3	0.3	0.2	-0.0	0.5
Bipolar Disorder (2018)	0.1	0.2	0.7	-0.2	-0.3	-0.3	-0.2	-0.3	-0.0	-0.5	-0.5	0.0	-0.5	0.6	0.6	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.8	0.4	0.1	0.3	-0.5	0.2	0.1	0.0	-0.1	1.4	-1.2	0.8	0.8	0.8
Worry (Nagel 2018)	0.1	0.2	0.9	-0.2	-0.1	-0.3	0.6	-0.2	-0.1	-0.1	-0.2	0.3	1.0	0.5	0.1	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.5	0.5	0.6	0.6	0.5	0.6	0.3	0.4	0.5	-0.6	-0.2	-0.1	0.2
Reaction Time	0.1	0.2	0.9	-0.2	-0.3	-0.2	-0.4	-0.3	-0.3	-0.2	0.0	1.0	0.7	-0.7	-0.4	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.0	0.3	0.2	0.6	0.2	0.2	0.1	0.0	0.2	0.7	0.0	0.1	0.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.6	0.5	0.5	0.4	0.5	0.5	0.2	0.4	-0.4	0.1	0.0	-0.6	0.0
Heel T-Score	0.1	0.4	0.8	-0.8	-0.7	-0.8	0.6	-0.8	-0.6	-0.9	-0.8	-0.3	-0.4	0.2	0.6	0.4
Height	0.1	2.7	5.9	2.4	2.0	2.2	1.1	2.1	1.9	2.0	1.6	1.1	1.3	-0.8	0.1	-0.4
Smoking Status	0.1	0.2	1.4	-0.5	-0.4	-0.6	-0.1	-0.4	-0.0	-0.4	-0.2	0.4	-1.2	-0.7	-0.4	-0.0
Hypothyroidism (self reported)	0.1	0.3	1.8	-0.2	-0.2	-0.0	-0.6	-0.1	-0.2	0.1	-0.1	-1.3	0.1	0.6	0.3	0.7
Lung FEV1/FVC ratio	0.1	0.5	2.7	0.2	0.4	0.4	0.4	0.5	0.4	0.6	-0.0	0.2	-1.6	0.9	1.0	0.7
Tanning	0.1	1.2	1.8	-1.2	-1.2	-1.2	-0.3	-1.3	-1.1	-1.0	-1.2	0.1	-1.1	1.1	1.3	1.1
Number of treatments/medications taken	0.1	0.1	0.6	-0.1	-0.1	0.0	-0.3	-0.1	0.0	-0.5	0.1	0.2	0.8	-0.2	-0.7	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.5	-0.4	-0.2	-0.3	0.5	-0.3	-0.2	-0.2	-0.4	-0.1	-0.4	0.2	0.7	0.2
Systolic blood pressure, automated reading	0.1	0.4	1.8	-0.2	0.3	-0.0	0.1	0.2	0.3	-0.1	0.4	-0.2	-0.9	-1.4	-0.8	-1.1
Townsend deprivation index at recruitment	0.1	0.1	0.9	0.1	0.1	0.0	-0.0	0.2	0.2	0.3	0.1	0.9	-0.6	-0.4	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.6	0.3	0.3	-0.0	0.3	0.3	0.0	-0.0	-0.1	-0.6	0.1	0.3	0.4
Taking other prescription medications	0.1	0.1	0.3	0.2	0.4	0.4	0.5	0.4	0.4	0.0	0.1	-0.0	0.3	0.5	0.5	0.3
Age when periods started (menarche)	0.1	0.2	0.5	-0.5	-0.5	-0.5	0.1	-0.5	-0.3	-0.3	-0.1	0.6	0.7	0.1	-0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.7	-0.3	-0.1	-0.1	0.3	-0.1	-0.1	0.2	0.2	0.2	-0.1	-0.8	-0.7	-0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.4	-0.3	-0.4	0.2	-0.4	-0.2	-0.5	-0.4	0.4	0.7	-0.2	0.3	-0.0
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.7	-0.5	-0.1	-0.2	0.2	-0.2	-0.1	-0.2	0.1	0.1	0.4	-0.4	-0.8	-0.5
Waist circumference	0.1	0.4	1.4	0.3	0.4	0.4	0.5	0.4	0.4	0.5	0.7	-0.8	-1.2	-0.9	-0.6	-0.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.7	0.3	0.4	0.4	0.7	0.4	0.4	0.1	0.2	0.8	-0.3	0.3	0.1	-0.1
Weight	0.1	0.5	3.1	-0.4	-0.4	-0.4	0.0	-0.5	-0.4	-0.4	-0.5	-0.0	-1.8	0.6	0.9	0.9
Arm fat percentage (right)	0.1	0.6	3.9	-0.5	-0.3	-0.4	-0.6	-0.4	-0.4	-0.4	-0.3	-1.3	-2.0	0.1	0.3	0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	-0.0	-0.1	-0.3	-0.2	-0.1	-0.0	-0.4	-0.2	0.1	-0.8	-0.7	0.0	-0.3
Arm fat mass (right)	0.1	0.5	4.2	-0.5	-0.4	-0.4	-0.3	-0.5	-0.5	-0.4	-0.3	-0.9	-2.0	0.2	0.4	0.5
Peak expiratory flow (PEF)	0.1	0.3	3.2	0.2	-0.1	0.1	-0.3	-0.0	-0.1	-0.1	-0.1	1.8	-0.1	0.3	0.0	0.2
Gout (self-reported)	0.1	0.1	0.4	0.2	0.5	0.4	-0.0	0.5	0.5	0.1	0.3	0.6	-0.2	0.2	0.2	-0.5
Arm fat-free mass (right)	0.1	0.4	1.4	-0.5	-0.5	-0.5	0.5	-0.6	-0.5	-0.3	-0.4	1.2	-0.9	0.1	0.6	0.7
Age at first live birth	0.1	0.2	1.4	0.2	0.4	0.4	-0.3	0.4	0.3	0.5	0.4	0.5	1.2	-0.1	-0.5	-0.3
Health satisfaction	0.1	0.1	0.8	-0.1	-0.0	0.1	-0.3	0.0	0.0	0.0	-0.1	0.3	0.0	0.9	0.0	0.1
Medication: Blood pressure	0.1	0.2	1.0	-0.1	-0.1	-0.2	-0.1	-0.2	-0.2	-0.8	-0.2	-1.0	-0.3	0.1	-0.4	-0.2
Mean time to correctly identify matches	0.1	0.2	0.5	0.5	0.4	0.4	0.5	0.4	0.5	0.5	0.4	-0.2	-0.6	-0.7	0.3	-0.2
Whole body fat mass	0.1	0.4	3.2	0.0	0.2	0.1	0.1	0.1	0.1	0.1	0.3	-1.0	-1.8	-0.6	-0.3	-0.2
Leg fat mass (right)	0.1	0.5	2.9	-0.9	-0.7	-0.8	-0.4	-0.7	-0.7	-0.6	-0.4	-0.8	-1.7	-0.1	0.0	0.2
Arm predicted mass (right)	0.1	0.3	1.2	-0.4	-0.4	-0.3	0.7	-0.5	-0.4	-0.1	-0.2	1.1	-0.8	0.1	0.5	0.6
Overall health rating	0.1	0.2	0.4	-0.3	-0.5	-0.5	-0.4	-0.5	-0.5	-0.6	-0.4	0.3	-0.4	0.3	-0.0	0.2
Had major operations	0.1	0.2	0.5	0.5	0.3	0.3	0.7	0.3	0.4	-0.1	-0.1	-0.3	0.3	0.6	0.5	0.4
Age at last live birth	0.1	0.2	1.2	-0.2	-0.0	-0.0	-0.1	-0.0	-0.1	0.2	-0.1	0.3	1.1	0.8	0.4	0.7
Medication: Aspirin	0.1	0.2	1.1	-0.1	-0.2	-0.2	-0.0	-0.3	-0.3	-0.2	-0.0	1.1	-0.0	-0.6	-0.3	-0.6
Hypertension (Self-reported)	0.1	0.3	1.1	-0.5	-0.3	-0.3	0.0	-0.4	-0.2	-0.8	0.1	0.1	-0.4	-0.6	-0.9	-1.1
Arm fat percentage (left)	0.1	0.6	4.2	-0.4	-0.2	-0.3	-0.5	-0.2	-0.3	-0.3	-0.0	-1.6	-2.1	-0.3	-0.0	-0.0
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.2	-0.1	-0.1	-0.1	-0.1	-0.1	-0.3	-0.3	-0.2	-0.6	0.7	0.4	0.6
Commuting to job workplace: Walk	0.1	0.1	0.7	-0.2	-0.2	-0.1	-0.3	-0.2	-0.2	-0.1	-0.2	-0.8	-0.3	-0.1	0.4	0.2
Arm fat mass (left)	0.1	0.5	4.1	-0.5	-0.4	-0.5	-0.2	-0.5	-0.5	-0.5	-0.3	-1.0	-2.0	0.0	0.4	0.5
Guilty feelings	0.1	0.1	0.7	-0.2	-0.4	-0.4	0.2	-0.4	-0.3	-0.1	-0.3	0.2	0.9	0.2	0.2	0.4
Medication: Lisinopril	0.1	0.1	0.4	0.5	0.4	0.4	0.7	0.3	0.4	0.1	0.2	-0.1	-0.0	0.4	0.3	0.2
Alcohol drinker status: Never	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.4	-0.3	-0.3	-0.4	-0.2	0.4	0.2	0.5	0.3	0.3
Leg fat percentage (left)	0.1	0.5	1.8	-0.6	-0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.2	-0.6	-1.3	-1.1	-1.1	-0.8
Arm fat-free mass (left)	0.1	0.7	1.6	-0.6	-0.5	-0.5	0.6	-0.7	-0.5	-0.4	-0.6	1.3	-1.1	0.8	1.1	1.2
Number of operations (self-reported)	0.1	0.2	0.7	-0.5	-0.3	-0.3	0.4	-0.4	-0.2	-0.3	-0.5	0.8	-0.3	0.2	0.4	0.1
Irritability	0.1	0.2	1.4	0.1	0.3	0.2	0.3	0.3	0.3	0.0	-0.0	1.2	0.7	0.7	0.1	0.4
Leg fat mass (left)	0.1	0.3	2.2	-0.6	-0.4	-0.5	-0.2	-0.5	-0.4	-0.4	-0.1	-0.6	-1.5	-0.4	-0.3	-0.0
Arm predicted mass (left)	0.1	0.5	2.1	-0.3	-0.2	-0.2	0.9	-0.4	-0.2	-0.1	-0.4	1.5	-1.0	0.6	0.9	1.0
Blood Red Count	0.0	0.4	2.2	0.2	0.4	0.3	1.5	0.3	0.5	0.2	0.0	1.4	-0.7	-0.2	0.0	0.2
Hair Pigment	0.0	0.5	3.0	-0.7	-0.4	-0.4	-0.3	-0.4	-0.6	-0.7	-0.1	-1.7	1.2	-0.1	-0.7	-0.0
Hip circumference	0.0	0.1	0.7	-0.3	-0.2	-0.2	0.1	-0.3	-0.2	-0.2	0.1	-0.5	-0.8	-0.2	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.5	-0.2	-0.2	-0.3	-0.7	-0.2	-0.1	-0.7	-0.1	0.1	-0.0	-0.3	0.0	-0.4

Hub : Genes

ABCD3

Models

Trait associations