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chr10:49,201,820-51,094,660

Best TWAS P=2.02e-42 · Best GWAS P=1.51e-46 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	The Cancer Genome Atlas	Soft Tissue Sarcoma	FAM170B	0.07	0.09	lasso	4	0.07	4.9e-05	-13.65	-13.6	2.0e-42	0.95	0.01	0.98	TRUE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	C10orf72	0.06	0.02	enet	7	0.05	1.3e-03	-9.66	12.7	6.5e-37	-0.82	0.01	0.90	FALSE
7	GTEx	Spleen	VSTM4	0.46	0.19	lasso	6	0.23	1.2e-06	-10.74	-11.9	2.0e-32	0.82	0.08	0.90	FALSE
4	GTEx	Muscle Skeletal	VSTM4	0.07	0.04	lasso	2	0.03	5.6e-04	-11.14	11.2	4.6e-29	-0.78	0.20	0.59	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM170B	0.09	0.10	blup	65	0.10	1.1e-11	-10.73	-11.2	5.8e-29	0.81	0.60	0.40	FALSE
8	GTEx	Spleen	C10orf128	0.37	0.05	lasso	11	0.09	2.6e-03	-13.42	-10.4	1.6e-25	0.72	0.05	0.73	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	C10orf128	0.11	0.05	lasso	5	0.06	1.0e-07	-8.60	-9.7	2.8e-22	0.70	0.04	0.96	FALSE
1	GTEx	Artery Tibial	VSTM4	0.15	0.00	lasso	3	0.00	4.1e-01	3.25	-9.6	8.9e-22	0.62	0.05	0.57	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C10orf128	0.05	0.02	blup	59	0.02	2.9e-03	-8.60	-9.4	4.3e-21	0.70	0.01	0.73	FALSE
6	GTEx	Spleen	WDFY4	0.39	0.00	lasso	8	0.03	5.8e-02	-1.80	-9.4	6.4e-21	0.49	0.04	0.68	FALSE
3	GTEx	Heart Left Ventricle	VSTM4	0.16	0.06	enet	12	0.08	5.8e-05	-13.13	9.2	2.3e-20	-0.72	0.06	0.91	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf128	0.02	0.00	enet	7	0.01	2.7e-03	-8.60	-9.0	1.8e-19	0.63	0.04	0.14	FALSE
12	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf128	0.14	0.03	blup	60	0.06	9.1e-04	4.76	-8.3	1.2e-16	0.60	0.00	0.86	FALSE
2	GTEx	Colon Sigmoid	ARHGAP22	0.25	0.02	enet	28	0.03	2.9e-02	-0.43	-8.1	4.1e-16	0.51	0.03	0.81	FALSE
9	GTEx	Testis	VSTM4	0.27	0.14	lasso	4	0.22	3.3e-10	4.66	-7.3	2.5e-13	0.39	0.97	0.02	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C10orf128	0.04	0.01	lasso	2	0.03	5.2e-04	-7.00	-6.8	8.7e-12	0.46	0.17	0.13	FALSE
5	GTEx	Pancreas	ARHGAP22	0.21	0.00	enet	18	0.00	2.6e-01	-10.75	-6.5	5.7e-11	0.56	0.07	0.16	FALSE
10	GTEx	Whole Blood	C10orf128	0.11	0.04	enet	20	0.05	3.0e-05	1.53	-5.5	3.3e-08	0.32	0.25	0.22	FALSE