Best TWAS P=2.02e-42 · Best GWAS P=1.51e-46 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | VSTM4 | 0.15 | 0.00 | lasso | 3 | 0.00 | 4.1e-01 | 3.25 | -9.6 | 8.9e-22 | 0.62 | 0.05 | 0.57 | FALSE |
| 2 | GTEx | Colon Sigmoid | ARHGAP22 | 0.25 | 0.02 | enet | 28 | 0.03 | 2.9e-02 | -0.43 | -8.1 | 4.1e-16 | 0.51 | 0.03 | 0.81 | FALSE |
| 3 | GTEx | Heart Left Ventricle | VSTM4 | 0.16 | 0.06 | enet | 12 | 0.08 | 5.8e-05 | -13.13 | 9.2 | 2.3e-20 | -0.72 | 0.06 | 0.91 | FALSE |
| 4 | GTEx | Muscle Skeletal | VSTM4 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.6e-04 | -11.14 | 11.2 | 4.6e-29 | -0.78 | 0.20 | 0.59 | FALSE |
| 5 | GTEx | Pancreas | ARHGAP22 | 0.21 | 0.00 | enet | 18 | 0.00 | 2.6e-01 | -10.75 | -6.5 | 5.7e-11 | 0.56 | 0.07 | 0.16 | FALSE |
| 6 | GTEx | Spleen | WDFY4 | 0.39 | 0.00 | lasso | 8 | 0.03 | 5.8e-02 | -1.80 | -9.4 | 6.4e-21 | 0.49 | 0.04 | 0.68 | FALSE |
| 7 | GTEx | Spleen | VSTM4 | 0.46 | 0.19 | lasso | 6 | 0.23 | 1.2e-06 | -10.74 | -11.9 | 2.0e-32 | 0.82 | 0.08 | 0.90 | FALSE |
| 8 | GTEx | Spleen | C10orf128 | 0.37 | 0.05 | lasso | 11 | 0.09 | 2.6e-03 | -13.42 | -10.4 | 1.6e-25 | 0.72 | 0.05 | 0.73 | FALSE |
| 9 | GTEx | Testis | VSTM4 | 0.27 | 0.14 | lasso | 4 | 0.22 | 3.3e-10 | 4.66 | -7.3 | 2.5e-13 | 0.39 | 0.97 | 0.02 | FALSE |
| 10 | GTEx | Whole Blood | C10orf128 | 0.11 | 0.04 | enet | 20 | 0.05 | 3.0e-05 | 1.53 | -5.5 | 3.3e-08 | 0.32 | 0.25 | 0.22 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C10orf128 | 0.02 | 0.00 | enet | 7 | 0.01 | 2.7e-03 | -8.60 | -9.0 | 1.8e-19 | 0.63 | 0.04 | 0.14 | FALSE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C10orf128 | 0.14 | 0.03 | blup | 60 | 0.06 | 9.1e-04 | 4.76 | -8.3 | 1.2e-16 | 0.60 | 0.00 | 0.86 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | C10orf72 | 0.06 | 0.02 | enet | 7 | 0.05 | 1.3e-03 | -9.66 | 12.7 | 6.5e-37 | -0.82 | 0.01 | 0.90 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C10orf128 | 0.04 | 0.01 | lasso | 2 | 0.03 | 5.2e-04 | -7.00 | -6.8 | 8.7e-12 | 0.46 | 0.17 | 0.13 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FAM170B | 0.09 | 0.10 | blup | 65 | 0.10 | 1.1e-11 | -10.73 | -11.2 | 5.8e-29 | 0.81 | 0.60 | 0.40 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | C10orf128 | 0.11 | 0.05 | lasso | 5 | 0.06 | 1.0e-07 | -8.60 | -9.7 | 2.8e-22 | 0.70 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C10orf128 | 0.05 | 0.02 | blup | 59 | 0.02 | 2.9e-03 | -8.60 | -9.4 | 4.3e-21 | 0.70 | 0.01 | 0.73 | FALSE |
| 18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FAM170B | 0.07 | 0.09 | lasso | 4 | 0.07 | 4.9e-05 | -13.65 | -13.6 | 2.0e-42 | 0.95 | 0.01 | 0.98 | TRUE |