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chr10:63,414,038-66,034,105

Best TWAS P=2.49e-290 · Best GWAS P=0 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	35.1	-36.4	2.5e-290	-0.90	0.26	0.74	TRUE
11	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	35.2	-32.4	1.4e-230	-0.83	0.61	0.38	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	-23.0	30.9	3.8e-209	0.72	0.03	0.97	TRUE
45	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	35.1	-30.1	2.0e-199	-0.78	0.02	0.21	TRUE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	35.2	-29.7	8.0e-194	-0.76	0.02	0.80	TRUE
14	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	-21.6	-28.3	1.2e-176	-0.67	0.06	0.55	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	-26.0	28.3	3.0e-176	0.67	1.00	0.00	TRUE
12	GTEx	Pituitary	REEP3	0.28	-0.01	enet	43	0.02	1.1e-01	2.5	11.6	3.8e-31	0.21	0.05	0.08	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	ADO	0.06	0.04	lasso	2	0.06	3.1e-08	8.2	-8.9	5.0e-19	-0.10	0.99	0.00	TRUE
9	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	-8.4	-8.9	6.9e-19	-0.07	1.00	0.00	TRUE
10	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	8.2	-8.4	3.9e-17	-0.02	0.95	0.00	TRUE
20	NTR	Blood	NRBF2	0.03	0.01	bslmm	386	0.01	3.4e-05	-7.8	7.7	1.5e-14	0.35	0.18	0.12	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADO	0.07	0.06	blup	53	0.05	2.5e-06	-8.0	-7.5	7.7e-14	-0.05	0.01	0.99	TRUE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADO	0.10	0.03	enet	6	0.06	4.6e-07	-8.0	-7.1	1.0e-12	-0.03	0.04	0.95	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARID5B	0.05	0.05	lasso	2	0.04	3.7e-05	6.6	-6.8	1.0e-11	-0.01	0.00	1.00	TRUE
16	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	35.2	-36.2	9.4e-287	-0.89	0.40	0.51	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	35.3	-36.2	2.1e-286	-0.89	0.04	0.96	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	35.3	-35.7	1.3e-279	-0.89	0.52	0.48	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	35.1	-35.6	2.1e-277	-0.89	1.00	0.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	35.1	-35.1	3.2e-270	-0.89	1.00	0.00	FALSE
4	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	-34.5	-35.1	6.9e-270	-0.87	0.14	0.85	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	35.3	-35.1	1.8e-269	-0.87	0.07	0.76	FALSE
5	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	35.1	-34.5	1.5e-261	-0.88	0.15	0.73	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	-22.8	-34.5	1.8e-261	-0.77	0.00	0.99	FALSE
7	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	35.2	-34.3	2.9e-258	-0.87	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	35.3	-34.3	1.8e-257	-0.87	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	35.1	34.2	2.5e-256	0.88	0.34	0.66	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	35.3	-33.9	1.6e-252	-0.84	0.35	0.64	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	-24.9	-32.3	1.2e-228	-0.79	0.87	0.12	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBF2	0.07	0.04	blup	42	0.02	7.3e-03	35.3	-30.5	8.4e-204	-0.77	0.05	0.59	FALSE
8	GTEx	Esophagus Muscularis	NRBF2	0.10	0.03	enet	22	0.03	3.8e-03	36.0	-30.1	1.2e-199	-0.71	0.02	0.94	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBF2	0.17	0.09	enet	10	0.13	1.1e-04	35.1	-29.3	1.2e-188	-0.80	0.06	0.55	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	35.3	-28.5	1.0e-178	-0.80	0.02	0.59	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NRBF2	0.08	0.01	blup	40	0.03	6.6e-03	-24.9	-28.2	3.2e-175	-0.60	0.01	0.25	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBF2	0.13	0.10	enet	11	0.09	4.9e-06	35.1	-27.2	2.0e-162	-0.70	0.26	0.39	FALSE
13	GTEx	Skin Sun Exposed Lower leg	NRBF2	0.06	0.01	lasso	3	0.00	4.0e-01	6.1	-24.1	1.3e-128	-0.53	0.07	0.18	FALSE
3	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	-24.5	23.9	3.3e-126	0.53	0.39	0.32	FALSE
19	GTEx	Thyroid	NRBF2	0.11	0.05	lasso	3	0.07	2.5e-06	-6.9	-23.1	1.1e-117	-0.66	0.10	0.88	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC84989	0.10	0.05	blup	19	0.04	7.7e-03	-10.2	-18.9	5.0e-80	-0.62	0.01	0.34	FALSE
6	GTEx	Cells Transformed fibroblasts	JMJD1C	0.09	0.01	enet	18	0.07	8.6e-06	-25.0	-15.9	5.3e-57	-0.50	0.23	0.44	FALSE
15	GTEx	Stomach	ADO	0.19	0.01	enet	31	0.10	1.0e-05	3.7	-13.8	2.5e-43	-0.30	0.09	0.16	FALSE
24	YFS	Blood	NRBF2	0.33	0.12	enet	54	0.17	1.2e-53	-7.8	-8.7	2.4e-18	-0.19	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADO	0.06	0.04	blup	55	0.01	1.4e-01	8.2	-8.6	5.9e-18	-0.07	0.02	0.57	FALSE
17	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	-8.4	8.6	1.2e-17	0.05	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADO	0.04	0.01	blup	465	0.02	1.8e-03	-8.0	-8.5	2.3e-17	-0.19	0.14	0.02	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	8.2	-8.4	3.2e-17	-0.05	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADO	0.03	0.02	blup	53	0.03	1.8e-06	-6.1	-8.2	3.1e-16	-0.06	0.12	0.88	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	ADO	0.14	0.05	blup	53	0.05	3.8e-06	6.1	-7.4	1.8e-13	-0.07	0.08	0.92	FALSE
18	GTEx	Testis	JMJD1C-AS1	0.22	0.08	enet	23	0.10	3.7e-05	-10.8	-7.2	4.7e-13	-0.37	0.67	0.04	FALSE