TWAS hub - TRIM5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0270	8.2e-03	0.026	0.021	0.045	0.028	0.032	3.7e-04	1.2e-03	3.1e-06	1.9e-04	8.2e-05
2	GTEx	Esophagus Mucosa	0.1910	0.0610	1.1e-03	0.041	NA	0.055	NA	0.044	9.4e-04	NA	1.5e-04	NA	6.1e-04
3	GTEx	Muscle Skeletal	0.1286	0.0432	2.0e-03	0.072	NA	0.049	NA	0.006	1.3e-07	NA	1.4e-05	NA	7.1e-02
4	YFS	Blood	0.0243	0.0110	1.2e-02	0.011	0.002	0.019	0.017	0.017	1.5e-04	7.5e-02	6.7e-07	1.8e-06	1.5e-06
5	TCGA	Breast Invasive Carcinoma	0.0593	0.0202	3.5e-05	0.040	0.019	0.028	NA	0.038	1.0e-08	5.8e-05	1.9e-06	NA	2.0e-08
6	TCGA	Cervical Squamous Cell Carcinoma	0.2040	0.0710	1.4e-03	-0.004	0.066	0.079	NA	0.003	5.9e-01	3.8e-04	1.0e-04	NA	2.3e-01
7	TCGA	Colon Adenocarcinoma	0.1450	0.0560	2.4e-03	0.034	0.066	0.066	NA	0.068	4.4e-03	1.1e-04	1.1e-04	NA	9.1e-05
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1091	0.0318	3.2e-06	0.096	0.063	0.078	NA	0.092	6.5e-11	1.3e-07	4.1e-09	NA	1.7e-10
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0739	0.0264	6.7e-04	0.064	0.022	0.040	NA	0.054	1.0e-07	1.5e-03	2.4e-05	NA	1.1e-06
10	TCGA	Brain Lower Grade Glioma	0.0771	0.0290	6.1e-04	0.066	0.031	0.063	NA	0.058	6.0e-08	1.7e-04	1.2e-07	NA	3.3e-07
11	TCGA	Lung Adenocarcinoma	0.0793	0.0297	4.3e-04	0.053	0.028	0.054	NA	0.054	7.1e-07	3.0e-04	6.0e-07	NA	5.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Blood Platelet Count	4.9	56.4	74.3	8.6	8.0	5.8	7.4	7.3	7.6	6.7	7.4	7.4	8.6	7.4
Medication: Lisinopril	4.2	5.5	11.4	0.6	-2.3	0.7	0.1	-2.9	-3.4	-3.4	-2.7	-2.7	-0.3	-2.9
Illnesses of father: High blood pressure	3.3	4.1	6.5	-1.0	-2.4	0.5	-2.4	-2.6	-1.9	-2.0	-2.5	-2.5	0.2	-2.3
Mouth/teeth dental problems	3.0	4.7	8.1	0.5	-2.9	0.5	-1.7	-2.7	-1.9	-2.5	-2.7	-2.7	-0.7	-2.8
Ulcerative Colitis (UC)	2.8	5.3	10.0	-0.8	2.7	-1.1	1.6	2.9	1.6	3.2	2.9	2.9	-0.2	3.0
Supplements: Glucosamine	2.8	3.6	8.7	-0.1	1.6	-0.6	1.3	2.5	1.3	2.9	2.4	2.4	0.3	2.6
Tinnitus: Yes, now most or all of the time	2.7	3.1	6.3	0.6	-1.8	1.8	-0.5	-2.4	0.7	-2.5	-2.2	-2.2	0.1	-2.3
Supplements: Fish oil (including cod liver oil)	2.7	3.5	6.8	-2.0	1.4	-1.3	1.0	2.6	0.8	2.1	2.5	2.5	-0.7	2.3
Average weekly spirits intake	2.6	3.2	7.8	1.5	-1.9	2.8	-1.7	-1.6	-0.6	-1.4	-1.6	-1.7	2.5	-1.5
Current tobacco smoking	2.6	4.3	14.3	1.8	-2.1	3.8	-0.1	-2.0	-1.5	-1.6	-1.9	-1.9	2.3	-1.9
Gout (self-reported)	2.6	3.6	7.9	-1.3	1.7	-1.2	0.1	2.3	2.2	2.8	2.3	2.3	0.1	2.3
Triglycerides	2.5	4.2	8.6	0.7	2.5	-0.6	0.5	2.8	0.7	2.2	2.8	2.8	1.1	2.9
Ulcerative Colitis	2.5	3.6	7.9	-0.9	2.2	-1.7	0.6	2.3	0.7	2.8	2.4	2.4	-0.9	2.3
Mouth/teeth dental problems: Mouth ulcers	2.5	4.1	10.8	-0.7	2.1	-0.3	1.0	2.4	1.8	3.3	2.4	2.4	1.1	2.3
Smoking status: Current	2.5	3.9	12.1	1.5	-2.1	3.5	-0.4	-1.9	-1.5	-1.5	-1.9	-1.9	2.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	6.3	0.4	-1.8	1.1	-2.5	-2.1	-0.0	-1.4	-2.2	-2.2	1.4	-1.9
Osteoporosis (self-reported)	2.4	3.0	5.7	-2.3	-1.4	-1.5	-1.0	-1.7	0.0	-2.2	-1.6	-1.6	-2.4	-1.9
Commuting to job workplace: Public transport	2.4	2.8	4.9	-1.8	2.0	-1.9	1.0	1.9	-0.5	1.6	1.9	1.9	-1.1	2.2
Rheumatoid Arthritis	2.2	3.0	14.3	-3.8	-0.2	-2.8	0.3	0.6	-0.1	0.5	0.6	0.6	-3.0	0.6
Medication: Ibuprofen	2.2	2.7	5.0	-0.1	-2.0	0.9	-2.2	-2.0	0.1	-1.3	-2.1	-2.1	1.1	-1.9
Severe depression (siblings)	2.1	2.3	4.8	-1.1	2.2	-1.1	-1.1	1.7	0.9	2.1	1.6	1.6	0.4	2.0
Medication: Ramipril	2.1	2.7	4.2	-1.4	1.3	-1.7	0.6	2.0	1.8	1.7	2.0	2.0	-1.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	6.0	2.2	-0.9	2.4	0.1	-1.0	-2.3	-0.8	-1.0	-1.0	1.9	-0.9
Happiness	2.0	2.5	9.7	-1.8	0.3	-2.8	0.7	0.8	1.2	1.4	0.8	0.8	-3.1	0.7
Coronary Artery Disease (CAD)	1.9	2.3	9.0	0.5	-1.2	-0.2	-2.1	-1.5	-3.0	-0.9	-1.5	-1.6	0.1	-1.4
Average weekly fortified wine intake	1.9	2.2	13.6	1.3	1.7	0.3	0.8	1.0	3.7	1.1	0.9	0.9	0.8	0.9
Mouth/teeth dental problems: Dentures	1.9	3.1	6.1	-0.3	2.5	-0.9	2.0	2.2	1.1	1.4	2.3	2.2	-0.3	2.2
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.4	-2.0	0.9	-1.1	0.1	1.9	-0.1	1.9	2.1	2.1	-0.4	1.8
Medication for pain relief, constipation, heartburn	1.8	3.0	5.8	-1.0	2.1	-0.4	1.2	2.4	0.4	2.1	2.4	2.4	0.6	2.1
Angina (self-reported)	1.8	2.3	4.3	1.7	-1.4	2.1	0.0	-1.9	0.1	-1.5	-1.7	-1.7	1.3	-1.7
Medication: Paracetamol	1.7	2.7	5.9	0.0	-1.5	0.0	-1.7	-2.1	-1.7	-2.4	-2.0	-2.0	-0.2	-1.8
Alcohol drinker status: Previous	1.7	1.9	3.6	1.4	-1.9	0.6	-1.5	-1.5	-0.7	-1.6	-1.6	-1.6	-0.0	-1.5
Angina	1.6	2.1	3.7	1.6	-1.3	1.9	0.1	-1.8	0.3	-1.6	-1.7	-1.7	1.0	-1.7
Pain all over the body in last month	1.6	1.7	3.3	-0.5	-0.6	-0.5	-0.9	-1.8	-1.0	-1.6	-1.8	-1.8	-0.8	-1.7
Exposure to tobacco smoke at home	1.6	1.8	5.3	0.7	1.3	1.7	0.2	1.1	1.8	0.8	1.2	1.2	2.3	1.2
Medication: Aspirin	1.6	2.1	6.5	2.5	-1.7	2.0	1.4	-1.2	-0.5	-1.2	-1.1	-1.1	-0.4	-1.1
Handedness (chirality/laterality): Left-handed	1.6	1.9	6.9	0.5	-0.7	-0.2	-2.6	-1.6	-0.6	-1.5	-1.7	-1.7	0.1	-1.6
LDL Cholesterol	1.5	2.4	7.5	-2.4	-1.8	-2.2	-0.3	-0.7	-1.6	-1.2	-0.6	-0.6	-2.7	-0.3
Fed-up feelings	1.5	2.7	6.2	-1.6	-1.6	-1.7	-1.9	-1.6	-0.9	-1.3	-1.5	-1.5	-2.5	-1.4
Medication: Simvastatin	1.5	2.2	6.9	1.1	-2.6	-0.7	-1.2	-1.6	-1.3	-1.1	-1.6	-1.6	-1.2	-1.4
Medication: Aspirin	1.5	2.0	4.9	2.2	-1.9	1.6	1.5	-1.2	-0.7	-1.3	-1.2	-1.1	-0.7	-1.3
High cholesterol (Self-reported)	1.5	2.6	8.0	0.9	-2.8	-0.2	-1.8	-1.8	-0.7	-1.2	-1.9	-1.9	-0.9	-1.9
HbA1C	1.4	1.5	4.9	0.7	-1.1	1.4	-1.8	-0.5	-2.2	0.6	-0.6	-0.6	1.8	-0.6
Relative age of first facial hair	1.4	2.8	5.0	2.2	-0.8	1.9	-1.2	-1.9	-0.1	-1.6	-2.0	-1.9	1.4	-2.1
Health satisfaction	1.4	1.8	5.8	-1.5	-0.9	-1.4	-0.5	-1.4	0.0	-1.0	-1.4	-1.4	-2.4	-1.2
Medication: Allopurinol	1.4	1.8	3.5	-0.6	1.1	-0.3	0.3	1.9	1.3	1.9	1.8	1.8	0.8	1.5
Commuting to job workplace: Walk	1.4	1.5	3.3	-1.0	1.2	-0.9	0.1	1.3	1.8	1.4	1.2	1.2	-1.0	1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.5	1.1	1.2	0.4	1.1	1.4	1.4	1.9	1.3	1.3	1.1	1.4
Major Depression (MDD)	1.3	1.5	5.7	0.6	-1.6	0.9	-0.9	-1.2	-0.5	-2.4	-1.1	-1.1	-0.4	-1.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.8	1.5	-0.5	0.9	-1.8	-1.3	-0.4	-0.7	-1.4	-1.4	0.3	-1.9
Illnesses of mother	1.3	1.6	2.9	1.3	-0.7	0.3	0.0	-1.7	1.0	-1.4	-1.7	-1.7	-0.8	-1.7
Headache pain in last month	1.3	2.3	5.3	-1.9	1.0	-2.3	-1.1	1.4	0.4	1.6	1.6	1.5	-1.4	1.5
Medication: Paracetamol	1.3	2.0	5.9	0.5	-1.2	0.3	-1.0	-1.9	-1.0	-2.4	-1.8	-1.8	-0.2	-1.6
Heart disease (siblings)	1.3	1.6	3.9	1.6	0.4	1.6	0.4	0.9	1.4	1.7	1.0	1.0	2.0	0.9
Systolic blood pressure, automated reading	1.2	3.4	13.5	-0.2	0.9	-0.1	3.7	2.0	1.4	1.5	2.2	2.2	0.0	2.1
Number of live births	1.2	1.7	5.4	1.4	1.0	1.6	0.7	1.2	1.5	1.1	1.1	1.1	2.3	0.6
Lung cancer (father)	1.2	1.4	3.4	-1.1	1.5	-0.8	-1.9	1.1	1.3	1.4	0.9	1.0	-0.0	0.9
Mineral and other dietary supplements	1.2	1.6	3.2	0.8	-0.7	0.5	-0.4	-1.8	-1.1	-1.6	-1.7	-1.7	0.1	-1.6
Illnesses of father: None of the above (group 1)	1.2	1.4	6.0	1.2	0.5	1.8	1.3	0.7	2.5	0.2	0.6	0.6	1.4	0.2
Ever taken oral contraceptive pill	1.2	1.3	3.8	-0.1	-1.0	1.1	-2.0	-1.1	-0.1	-0.6	-1.2	-1.2	1.5	-1.2
Diastolic blood pressure, automated reading	1.2	3.7	14.5	0.7	1.6	0.8	3.8	2.1	0.9	1.8	2.2	2.2	1.0	1.9
Irritable Bowel Disease (IBD)	1.1	2.7	4.8	-0.9	2.2	-2.0	0.5	1.8	0.5	2.1	1.8	1.8	-1.1	1.9
Hand grip strength (left)	1.1	2.8	4.9	0.5	1.4	0.7	1.7	2.2	1.5	1.4	2.2	2.2	1.5	2.1
High blood pressure (mother)	1.1	1.6	3.3	-0.3	0.1	0.2	0.2	1.8	0.4	1.8	1.8	1.8	0.9	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.9	-2.0	0.2	-1.7	-1.3	0.9	0.8	1.1	0.9	0.9	-1.1	1.3
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	0.6	-1.3	0.8	-1.6	-1.3	-0.1	-1.2	-1.4	-1.4	-0.1	-1.4
Respiratory disease	1.0	2.1	4.6	-1.2	0.7	-0.2	1.0	1.9	-1.0	2.1	1.9	1.9	0.8	1.7
Lung FEV1/FVC ratio	1.0	5.3	11.0	1.2	-2.2	0.5	-1.5	-2.9	-2.1	-3.3	-2.9	-2.9	-1.1	-2.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.4	0.4	0.2	0.5	-1.7	-1.3	0.9	-1.8	-1.3	-1.3	0.7	-1.1
Diabetes (father)	1.0	1.3	4.6	-1.5	0.9	-2.1	-2.0	0.5	-0.0	0.2	0.5	0.5	-1.1	0.5
Heart attack	1.0	1.2	2.7	1.4	-1.6	1.1	0.8	-1.1	-0.4	-0.9	-1.1	-1.1	0.2	-1.4
Tense / ‘highly strung’	1.0	1.6	5.3	-2.3	0.2	-1.6	0.8	0.8	1.0	0.9	0.7	0.8	-2.3	0.5
Medication: Seretide 50 evohaler	1.0	1.2	4.0	0.5	-0.6	1.4	-0.1	-0.7	-2.0	-1.5	-0.7	-0.7	1.1	-1.2
Mean time to correctly identify matches	1.0	1.9	5.7	2.3	0.4	1.6	-0.6	0.5	1.8	1.6	0.4	0.4	2.4	1.0
Smoking status: Previous	1.0	1.5	4.5	-1.3	1.6	-2.1	-0.2	1.1	0.2	0.9	1.1	1.1	-1.2	1.1
Age at First Birth	0.9	1.3	6.9	0.5	-1.1	2.6	1.0	-0.4	0.8	0.2	-0.6	-0.5	1.8	-0.2
Hearing difficulty/problems: Yes	0.9	1.4	4.4	-2.1	0.3	-2.0	0.1	0.7	-1.3	0.8	0.9	0.9	-1.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.3	-0.0	-0.0	-2.1	0.4	-0.1	-1.5	-0.4	0.0	0.0	-2.0	-0.0
Vitamin and mineral supplements	0.9	1.3	4.9	2.2	0.4	1.9	0.8	-0.2	0.1	-0.4	-0.2	-0.2	2.1	-0.1
Worrier / anxious feelings	0.9	1.7	4.2	-2.0	1.4	-2.0	1.4	0.8	-0.3	0.7	0.8	0.8	-2.0	0.6
Hair/balding pattern: Pattern 4	0.9	2.3	4.2	0.1	1.9	-0.8	1.9	1.8	-0.1	1.5	1.9	1.9	-0.1	2.0
Worry too long after embarrassment	0.9	1.6	5.7	-1.5	1.8	-2.4	-0.7	0.7	0.9	0.5	0.6	0.6	-1.8	0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.5	1.5	0.6	1.0	0.9	0.7	1.2	1.1	0.7	0.7	1.6	0.8
Neck or shoulder pain in last month	0.9	1.3	3.3	1.6	0.2	1.8	1.2	1.0	-0.2	1.1	1.1	1.0	1.3	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.7	-1.4	-0.0	-1.1	-1.1	-0.0	-1.5	-1.3	0.0	0.0	-1.9	-0.2
Family relationship satisfaction	0.9	1.1	4.3	-0.2	0.5	-0.4	0.8	1.1	1.4	2.1	1.0	1.0	0.4	1.0
Illnesses of father: Heart disease	0.9	1.2	3.5	-0.7	-1.7	-0.7	-0.2	-1.3	-1.9	-0.6	-1.2	-1.2	-0.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.3	0.2	-1.4	0.5	-1.2	-1.0	0.6	-1.5	-1.1	-1.1	0.7	-1.2
Alcohol drinker status: Never	0.9	1.1	3.1	0.8	1.2	0.8	1.8	1.2	0.7	0.3	1.3	1.3	0.3	0.9
Myopia	0.9	1.3	2.3	0.2	-1.3	-0.6	-1.3	-1.3	-0.8	-1.2	-1.2	-1.2	-0.9	-1.5
Breast Cancer	0.8	1.9	3.8	0.6	1.0	-1.1	0.1	1.9	0.1	1.8	1.9	1.9	0.2	2.0
Bipolar Disorder (2011)	0.8	0.7	3.0	-0.7	0.8	-1.7	0.4	0.4	0.6	1.1	0.3	0.4	-1.1	0.8
Crohns Disease (2012)	0.8	1.2	3.2	0.2	-0.0	-1.8	-1.5	-0.9	-1.2	-0.6	-1.0	-1.0	-1.6	-0.9
Taking other prescription medications	0.8	1.2	2.2	-1.0	1.2	-1.2	-1.5	1.2	-0.4	0.7	1.1	1.2	-0.9	1.1
Medication: Atenolol	0.8	1.0	3.8	1.3	-0.1	0.8	-0.3	-1.1	-0.4	-1.9	-0.9	-0.9	0.6	-1.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.9	-0.3	0.1	0.6	0.2	1.0	1.4	0.3	1.0	1.0	2.0	0.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.6	-0.8	-1.2	0.1	-1.3	-1.2	-1.9	-0.6	-1.2	-1.2	0.2	-1.2
High blood pressure (siblings)	0.8	1.2	4.6	1.1	-1.4	2.1	1.5	0.3	-0.3	0.9	0.5	0.5	1.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.2	0.5	-1.2	0.6	-1.5	-1.0	-1.1	-0.6	-1.0	-1.0	1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	4.0	2.0	1.8	1.8	1.8	0.5	-0.8	0.0	0.6	0.7	1.9	0.5
Age started oral contraceptive pill	0.8	1.0	2.0	-0.1	0.9	-0.9	0.8	1.4	1.0	0.5	1.4	1.4	-0.3	1.3
Commuting to job workplace: Cycle	0.8	0.9	2.0	0.3	1.0	-0.1	0.3	1.4	0.2	1.1	1.4	1.4	0.2	1.4
Supplements: Calcium	0.8	0.9	2.4	-1.4	1.2	-1.2	0.3	-0.2	1.5	-0.1	-0.1	-0.1	-1.6	-0.0
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.3	1.3	-1.5	1.0	0.8	-1.0	-0.3	-0.9	-1.0	-1.0	0.2	-1.3
Depressed Affect (Nagel 2018)	0.7	1.5	3.3	-1.0	-1.8	-0.5	-1.8	-1.2	-0.8	-1.0	-1.2	-1.2	-0.8	-1.2
Alzheimer’s Disease (in mother)	0.7	0.8	3.5	-1.9	-0.5	-1.1	-0.3	0.6	-0.1	0.6	0.5	0.5	-1.5	0.7
Reaction Time	0.7	1.4	4.3	1.3	0.5	1.3	-1.2	0.6	1.2	1.8	0.4	0.4	2.1	0.9
Supplements: Zinc	0.7	0.8	1.6	0.6	-0.9	0.7	-0.2	-1.1	0.2	-1.3	-1.0	-1.0	0.5	-1.2
Hand grip strength (right)	0.7	1.9	3.6	-0.3	0.8	0.4	1.9	1.7	1.5	0.7	1.9	1.9	0.7	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.2	0.7	0.6	-0.4	0.7	1.8	-1.7	1.2	1.7	1.7	0.6	1.8
Diabetes (self-reported)	0.7	1.0	3.4	1.0	0.8	-1.6	0.5	0.8	0.3	0.8	0.9	0.9	-1.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.9	0.8	0.3	1.3	0.9	0.7	0.9	1.0	1.0	0.7	0.8
Pulse wave peak to peak time	0.7	0.8	2.7	1.3	-1.0	0.9	-0.6	-0.6	-1.6	-0.7	-0.6	-0.6	0.5	-0.7
Emphysema/chronic bronchitis	0.7	0.8	1.4	-0.7	-0.2	0.5	1.2	1.1	-0.7	0.9	1.2	1.2	0.7	0.9
Number of full sisters	0.7	0.8	5.9	-0.4	-0.1	0.9	-2.4	-0.5	0.0	-0.2	-0.6	-0.6	0.8	-0.7
Age at last live birth	0.7	1.1	3.9	0.1	0.7	1.0	1.3	1.1	-0.2	0.5	1.0	1.0	2.0	0.9
Average weekly red wine intake	0.7	1.0	5.2	0.6	-2.3	0.9	1.6	-0.4	-0.0	-0.1	-0.5	-0.5	0.5	-0.9
Miserableness	0.7	1.2	1.7	-1.1	-1.2	-0.9	-1.3	-1.2	-0.7	-0.4	-1.2	-1.2	-1.3	-1.1
Guilty feelings	0.7	1.1	1.9	-1.0	1.1	-1.4	0.0	1.3	-0.2	1.4	1.2	1.2	-0.5	1.2
Hearing aid user	0.7	0.8	4.3	-0.8	-0.3	-1.2	0.5	0.1	1.3	0.1	0.1	0.1	-2.1	0.1
Medication for hormone replacement therapy	0.6	0.7	3.4	1.8	0.7	0.6	0.1	0.2	0.9	-0.1	0.1	0.1	1.5	0.2
Qualifications: CSEs or equivalent	0.6	0.8	3.5	0.7	0.8	1.1	-1.1	-0.0	-1.1	0.6	-0.2	-0.2	1.9	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.9	-1.3	-0.7	-0.8	-1.0	-0.5	1.1	-0.1	-0.4	-0.4	-2.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.8	-1.7	-1.4	-0.7	-1.0	-0.3	0.3	-0.5	-0.1	-0.2	-0.7	-0.2
Breastfed as a baby	0.6	0.7	3.0	1.4	0.5	0.9	1.7	0.2	1.1	0.0	0.1	0.1	0.8	0.0
Birth weight of first child	0.6	1.2	3.8	2.0	-0.1	1.0	0.8	-1.1	-0.2	-0.9	-1.0	-1.0	-1.2	-1.5
Blood clot in the leg (DVT)	0.6	0.8	3.8	0.5	0.5	0.1	-1.9	-0.4	-1.3	-0.4	-0.7	-0.7	1.2	-0.2
Medication: Amlodipine	0.6	0.9	2.6	-0.3	-1.6	-0.8	-0.6	-1.3	-0.0	-0.7	-1.2	-1.2	-0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	4.3	0.4	1.0	0.0	0.5	0.5	2.1	0.6	0.6	0.6	0.4	0.6
Heart disease (mother)	0.6	0.8	2.9	-1.1	-1.7	-0.5	-0.4	-0.8	-0.2	-0.6	-0.8	-0.8	-1.0	-0.7
Comparative height size at age 10	0.6	3.5	12.6	1.5	3.5	0.4	1.1	1.9	1.5	1.6	1.9	1.9	1.9	1.8
Illnesses of siblings: Diabetes	0.6	0.7	1.5	0.3	-0.9	0.2	-0.0	-1.2	0.8	-0.9	-1.0	-1.1	-0.8	-1.2
Mood swings	0.6	1.1	3.1	-1.8	-0.5	-1.2	-1.3	-0.8	0.3	-0.5	-0.8	-0.9	-1.5	-0.9
Diabetes diagnosed by doctor	0.6	1.0	2.8	1.7	0.8	-0.6	0.3	1.0	0.3	0.7	1.1	1.1	-1.3	0.9
Medication: Gliclazide	0.6	0.7	1.9	0.4	1.0	-1.4	0.7	-0.2	1.3	-0.3	-0.2	-0.2	-1.3	0.2
Financial situation satisfaction	0.6	0.7	3.1	0.6	-0.1	0.0	0.9	-0.9	-1.8	-0.4	-0.8	-0.8	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	2.2	-0.5	0.6	0.1	0.9	0.6	1.5	1.2	0.7	0.7	0.8	0.8
Neuroticism (Nagel 2018)	0.5	1.3	2.6	-1.6	-1.0	-1.2	-1.1	-0.8	-1.0	-0.8	-0.9	-0.9	-1.6	-1.2
Blood Red Count	0.5	5.2	10.6	-0.5	1.6	-0.8	1.4	3.2	1.4	2.9	3.2	3.2	-0.5	3.2
Heel T-Score	0.5	3.8	7.1	-0.8	1.5	-1.0	1.4	2.6	1.2	2.7	2.6	2.6	-0.2	2.7
Cardiovascular Disease	0.5	1.6	5.6	-1.8	-0.7	-1.6	-0.5	-0.4	-2.0	-0.8	-0.4	-0.4	-2.4	-0.8
Relative age voice broke	0.5	0.8	1.9	1.2	-0.4	1.4	-0.3	-1.1	0.0	-0.4	-1.1	-1.1	0.1	-1.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.4	-2.1	-0.0	-1.2	0.1	0.6	-1.8	0.2	0.7	0.7	-1.2	0.7
Multivitamins +/- minerals	0.5	0.6	3.8	-1.1	-0.8	-0.9	0.0	0.1	0.6	-0.2	0.0	0.0	-1.9	-0.0
Waist circumference	0.5	1.8	9.7	2.0	0.3	1.4	0.3	0.4	3.1	0.6	0.2	0.3	1.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.1	-1.4	-0.1	-1.3	0.8	0.2	0.4	-0.4	0.3	0.3	-1.4	0.3
Illnesses of siblings	0.5	0.7	2.4	-1.1	1.2	-1.5	-1.0	-0.3	-0.2	-0.8	-0.6	-0.6	-0.8	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.8	0.3	0.0	-0.2	-1.1	-1.3	0.0	-1.3	-1.2	-1.2	-0.9	-1.2
Hair/balding pattern: Pattern 3	0.5	0.7	2.8	0.6	-0.7	0.9	-1.7	-0.3	0.1	-0.1	-0.6	-0.6	1.5	-0.4
Noisy workplace	0.5	0.6	2.5	0.0	-0.7	1.2	0.6	-0.8	0.1	-0.5	-0.7	-0.7	1.6	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.0	0.1	-1.2	1.4	1.0	-1.1	-1.2	-0.8	-1.1	-1.1	1.1	-1.1
Asthma	0.5	1.0	1.9	-0.6	0.3	0.4	0.5	1.4	-0.7	1.4	1.4	1.4	1.1	1.2
Medication: Cholesterol lowering	0.5	0.7	1.9	1.4	-1.4	-0.3	-0.5	-0.8	-0.6	-0.3	-0.8	-0.8	-1.0	-0.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.3	-1.0	1.1	-0.7	0.3	0.5	1.5	0.8	0.5	0.5	-0.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.6	-1.0	0.2	-1.6	-1.1	0.5	-0.5	0.7	0.5	0.5	-1.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	-0.3	1.0	-0.5	0.1	0.8	1.0	1.1	0.8	0.7	0.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.0	-0.4	0.3	-0.7	-1.0	1.2	0.4	1.3	1.2	1.2	-1.4	0.9
Birth weight	0.5	1.1	2.2	1.3	-0.9	0.5	0.6	-1.3	-0.2	-1.2	-1.2	-1.3	-0.6	-1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.6	-1.2	0.3	-0.4	0.6	0.4	-1.6	-0.3	0.6	0.5	-0.4	0.3
Age at first live birth	0.5	0.9	2.1	0.2	0.6	0.4	1.4	1.2	0.1	0.5	1.2	1.2	1.4	1.1
Shortness of breath walking on level ground	0.5	0.5	1.6	0.0	-1.2	0.8	-1.3	-0.5	-0.3	-0.1	-0.5	-0.5	1.1	-0.5
Overall health rating	0.5	1.1	3.9	-1.0	-1.0	-0.8	-0.4	-1.1	-0.3	-1.1	-1.0	-1.0	-2.0	-1.2
Chest pain or discomfort	0.5	0.7	2.1	-0.8	-1.4	1.3	-0.2	-0.8	-0.4	-0.2	-0.7	-0.8	0.9	-0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.9	-0.5	-0.2	-1.0	-1.0	-0.1	-1.0	-1.0	-1.0	-0.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	1.1	-0.8	1.4	-0.3	-0.5	0.3	-1.1	-0.4	-0.4	0.6	-0.2
Long-standing illness, disability or infirmity	0.5	0.7	3.5	-1.4	-0.1	-0.9	-1.1	0.1	-1.9	0.3	0.1	0.1	-0.7	0.2
Asthma (self-reported)	0.5	1.0	1.8	-0.6	0.1	0.5	0.4	1.3	-0.8	1.1	1.3	1.3	1.3	1.1
Cholesterol lowering medication	0.5	0.8	2.4	0.2	-1.5	-0.6	-0.8	-1.0	-0.3	-0.8	-1.1	-1.1	-0.8	-1.0
Bipolar Disorder (2018)	0.4	0.6	2.8	-0.7	-0.0	-1.6	0.4	0.2	0.0	-0.0	0.2	0.2	-1.7	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	3.6	0.4	-0.4	0.4	-1.9	-0.2	-0.6	-0.9	-0.2	-0.2	-0.0	-0.3
Worry (Nagel 2018)	0.4	0.8	3.4	-1.5	-0.1	-1.3	0.9	0.1	-0.7	-0.3	0.1	0.1	-1.8	-0.1
Ovarian Cancer	0.4	0.5	1.3	-1.1	-1.0	-0.3	-1.0	0.4	-0.7	0.7	0.4	0.4	1.0	0.2
Prostate Cancer	0.4	0.5	3.1	1.3	0.6	0.4	-0.5	-0.0	-0.5	-0.2	-0.1	-0.1	1.8	-0.3
HDL Cholesterol	0.4	0.7	2.0	0.4	-1.4	1.3	0.6	-0.8	0.6	0.3	-0.7	-0.7	0.9	-0.7
BMI	0.4	2.1	6.2	2.1	0.7	1.2	-0.1	0.9	2.5	1.2	0.8	0.8	2.4	0.8
Height	0.4	7.4	21.3	4.6	2.8	4.0	2.7	1.7	0.4	1.0	1.6	1.6	4.1	1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-1.1	-0.2	-0.9	-1.4	-0.4	0.5	-0.5	-0.5	-0.5	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.2	0.2	-0.2	0.6	-0.5	-0.9	-0.8	-0.3	-0.8	-0.8	1.1	-0.6
Medication: Co-codamol	0.4	0.4	2.7	0.6	-0.4	0.3	-0.5	-0.4	1.6	0.0	-0.5	-0.5	-0.2	-0.4
Medication: Metformin	0.4	0.5	3.0	1.7	0.1	-0.7	0.4	0.5	-0.0	0.6	0.6	0.6	-0.6	0.7
Impedance of leg (right)	0.4	2.0	4.1	-0.2	-1.3	0.6	-0.4	-1.8	-1.7	-1.8	-1.8	-1.8	-0.7	-2.0
Maternal smoking around birth	0.4	0.6	2.5	-1.6	0.2	-0.4	-1.1	0.6	1.0	0.5	0.5	0.5	-0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	-0.3	0.7	0.2	-0.2	-1.0	0.1	-0.8	-1.0	-0.9	-0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	6.1	0.4	0.1	0.1	0.7	0.9	-2.5	0.1	0.9	0.9	0.6	0.8
Nervous feelings	0.4	0.7	2.3	-0.8	1.0	-0.7	1.5	0.8	0.1	0.5	0.8	0.8	-0.9	0.8
Hair/balding pattern: Pattern 2	0.4	0.5	2.7	0.2	0.3	0.6	1.6	0.6	0.9	0.5	0.8	0.8	-0.2	0.4
Allergy	0.4	0.9	4.2	2.0	0.6	1.0	0.3	-0.1	2.0	-0.1	-0.1	-0.1	0.5	-0.1
Neuroticism score	0.4	0.8	2.6	-1.6	0.7	-1.5	-0.5	0.5	0.2	1.2	0.4	0.4	-1.1	0.4
Weight	0.4	1.9	5.0	2.2	1.1	1.4	0.9	1.0	2.2	0.9	0.8	0.8	1.9	0.7
Trunk fat-free mass	0.4	2.2	5.7	2.4	1.6	2.0	1.1	0.7	1.9	0.4	0.6	0.6	2.2	0.5
Falls in the last year	0.4	0.5	1.7	1.3	1.3	0.3	1.0	0.1	0.6	-0.1	0.2	0.2	0.4	0.4
Prospective memory result	0.4	0.6	1.1	0.2	-0.7	-0.4	-1.1	-0.9	1.0	-0.4	-0.8	-0.8	-0.6	-0.7
Trunk predicted mass	0.4	2.2	6.2	2.5	1.7	2.0	1.1	0.7	1.9	0.4	0.6	0.6	2.2	0.5
Glaucoma (self-reported)	0.4	0.4	1.3	-0.3	-1.2	-0.2	-0.6	-0.7	-0.1	-0.2	-0.7	-0.7	-1.1	-0.7
Arm fat-free mass (right)	0.4	1.8	4.5	1.9	1.8	1.5	1.1	0.8	2.1	0.6	0.8	0.8	1.7	0.7
Exposure to tobacco smoke outside home	0.4	0.6	2.9	1.2	0.7	0.6	-1.7	-0.1	-0.6	0.2	-0.1	-0.1	0.7	0.1
Loneliness, isolation	0.4	0.6	1.7	-0.5	0.0	-1.1	-0.7	0.8	-0.2	1.3	0.8	0.8	-0.6	0.7
Average weekly champagne plus white wine intake	0.4	0.6	2.1	-0.1	-1.4	0.1	0.4	-0.9	0.7	-0.4	-1.0	-1.0	-0.4	-0.9
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.1	0.6	-0.6	-0.5	1.0	-0.9	0.7	1.0	1.1	-0.3	0.9
Basal metabolic rate	0.4	1.9	4.4	2.1	1.7	1.6	0.9	1.0	1.8	0.7	0.8	0.8	2.1	0.8
Arm fat-free mass (left)	0.4	1.9	5.1	2.2	1.7	1.5	1.2	0.7	2.2	0.3	0.7	0.7	1.6	0.5
Irritability	0.4	0.6	1.6	-1.3	0.7	-0.6	-0.4	0.8	-0.9	1.3	0.8	0.7	0.0	0.7
Fractured/broken bones in last 5 years	0.4	0.5	0.7	0.8	0.5	0.5	0.8	0.6	-0.7	0.7	0.8	0.8	0.4	0.8
Ever depressed for a whole week	0.4	0.4	3.1	-1.8	-0.0	-0.7	-0.4	0.4	-0.6	-0.4	0.4	0.4	0.1	0.3
Unable to work because of sickness or disability	0.4	0.6	2.4	1.2	0.4	1.6	-0.6	-0.1	0.2	-0.5	-0.1	-0.1	1.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	0.7	0.9	0.0	-1.4	-0.1	-0.9	0.0	-0.4	-0.4	1.3	0.1
Arm predicted mass (left)	0.4	2.3	6.2	2.2	1.9	1.5	1.2	1.0	2.5	0.6	0.9	0.9	1.7	0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.8	-0.6	-0.3	-1.3	0.6	0.2	-0.1	0.5	0.6	-0.5	0.3
Crohns Disease (2017)	0.3	0.7	2.0	-0.6	0.5	-1.4	-0.6	-0.5	-1.4	-0.3	-0.4	-0.4	-1.2	-0.4
Fasting Glucose	0.3	0.3	1.2	0.5	1.0	-0.3	-0.8	0.2	-0.6	-1.1	0.1	0.1	0.0	0.2
Lupus	0.3	0.4	2.1	-0.1	-0.0	0.9	-0.1	-0.1	-0.7	1.1	-0.0	-0.0	1.5	0.3
Systolic Blood Pressure	0.3	1.6	5.6	-2.0	0.3	-0.9	2.4	0.5	-1.6	0.2	0.8	0.8	-1.4	0.8
Allergy or Eczema	0.3	0.7	3.0	-1.6	0.0	-0.6	-0.8	0.5	-1.7	0.4	0.5	0.5	-0.3	0.3
Hypothyroidism (self reported)	0.3	0.6	1.3	0.1	-0.1	-0.6	-1.1	0.8	-0.8	0.8	0.9	0.8	-1.0	0.7
Chronotype (morning person)	0.3	0.6	2.6	-1.6	0.1	-0.0	0.8	0.4	-1.6	0.3	0.3	0.3	0.5	0.1
Sensitivity / hurt feelings	0.3	0.6	3.3	-0.9	1.8	-1.1	-0.1	-0.0	0.2	0.8	-0.0	-0.0	-0.5	0.1
Diabetes (mother)	0.3	0.4	0.7	-0.4	-0.6	0.5	-0.3	0.9	-0.1	0.6	0.9	0.9	0.8	0.8
Leg fat-free mass (left)	0.3	1.5	3.9	1.8	1.5	1.2	0.4	0.9	1.1	0.8	0.8	0.8	2.0	0.8
Townsend deprivation index at recruitment	0.3	0.4	2.6	-1.6	0.2	-0.7	-0.2	0.1	0.3	0.5	0.1	0.1	-0.7	0.6
Sitting height	0.3	2.2	7.7	2.7	0.4	2.8	0.0	-0.5	0.2	-0.9	-0.4	-0.4	2.7	-0.5
Body mass index (BMI)	0.3	1.1	6.9	0.9	0.3	0.2	0.4	0.9	2.6	1.0	0.7	0.8	0.6	0.7
Impedance of leg (left)	0.3	1.4	3.6	-0.2	-1.1	0.7	-0.1	-1.3	-1.9	-1.6	-1.3	-1.3	-0.5	-1.6
Trunk fat mass	0.3	1.4	3.9	2.0	0.8	0.9	0.6	1.0	1.5	1.2	0.8	0.8	1.7	0.7
Past tobacco smoking	0.3	0.5	1.3	1.1	-1.1	0.9	0.4	-0.7	-0.1	-0.5	-0.7	-0.7	0.4	-0.6
Alcohol usually taken with meals	0.3	0.4	1.7	-0.2	-1.3	-0.2	-0.1	-0.4	0.6	-1.0	-0.4	-0.4	-0.4	-1.0
Qualifications: None of the above	0.3	0.6	3.0	-0.3	-0.7	-0.4	-0.2	-0.3	1.3	-0.8	-0.2	-0.2	-1.7	-0.4
Financial difficulties in last 2 years	0.3	0.4	1.7	-0.3	1.2	0.3	0.0	0.5	-1.3	0.4	0.5	0.5	0.1	0.6
Time employed in main current job	0.3	0.3	1.4	0.0	0.0	-0.4	-1.2	0.3	0.9	1.0	0.2	0.2	-0.1	0.3
Arm fat mass (right)	0.3	1.1	3.9	1.4	0.7	0.4	0.6	1.0	2.0	1.1	0.9	0.9	1.0	0.8
Standing height	0.3	2.6	9.5	2.6	1.8	2.8	0.9	0.2	-0.5	-0.0	0.2	0.2	3.1	-0.1
Loud music exposure frequency	0.3	0.3	1.2	-1.1	-0.6	-0.7	-0.1	-0.5	0.3	-0.3	-0.4	-0.4	-0.5	-0.2
Number of children fathered	0.3	0.3	1.2	-0.1	-0.0	0.1	0.0	0.7	-0.1	1.1	0.7	0.7	0.5	0.6
Migraine (self-reported)	0.3	0.3	1.1	-0.8	0.9	-1.0	-0.7	0.0	0.6	0.5	-0.1	-0.1	0.1	-0.3
Medication: Omeprazole	0.3	0.3	1.4	-0.7	-0.0	-0.0	0.3	0.6	1.2	0.4	0.6	0.6	0.5	0.4
Whole body fat mass	0.3	1.4	3.7	1.9	0.8	0.9	0.6	1.1	1.7	1.2	0.9	0.9	1.5	0.8
Arm predicted mass (right)	0.3	1.8	5.0	1.6	1.9	1.1	1.1	1.0	2.2	0.6	1.0	1.0	1.4	0.9
Pulse rate, automated reading	0.3	0.8	2.6	1.1	-0.5	1.6	1.5	-0.7	0.5	-0.1	-0.7	-0.7	1.0	-0.2
Leg pain on walking	0.3	0.3	1.3	-0.6	-0.8	-0.5	-0.2	-0.2	1.2	-0.4	-0.2	-0.2	-0.8	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.8	0.8	0.5	-0.1	-0.3	0.1	1.1	0.5	0.1	0.0	1.3	0.2
Supplements: Vitamin C	0.3	0.3	2.3	0.0	0.3	-0.1	-0.9	0.0	1.5	0.3	0.0	0.0	0.3	-0.1
Knee pain experienced in last month	0.3	0.4	1.2	0.7	-0.0	0.8	0.5	0.6	-0.5	1.1	0.6	0.6	0.6	0.2
Whole body fat-free mass	0.3	1.9	4.6	2.1	1.7	1.7	0.9	0.9	1.7	0.6	0.8	0.8	2.1	0.7
Leg fat-free mass (right)	0.3	1.5	4.8	1.7	1.6	1.3	0.4	1.0	0.8	0.8	0.9	0.9	2.2	0.9
Qualifications: nursing, teaching	0.3	0.4	1.9	-0.1	-0.6	0.2	1.4	-0.3	1.1	0.8	-0.3	-0.3	0.3	-0.1
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.8	0.1	-1.0	-0.1	0.5	0.5	-0.1	0.6	0.6	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	5.1	2.3	-0.9	0.7	0.5	0.0	0.4	0.3	-0.0	-0.0	0.1	0.2
Whole body water mass	0.3	2.0	4.5	2.1	1.8	1.6	1.1	0.9	1.8	0.6	0.8	0.8	2.0	0.8
Leg predicted mass (right)	0.3	1.5	4.8	1.7	1.6	1.3	0.4	0.9	0.8	0.7	0.8	0.8	2.2	0.9
Arm fat mass (left)	0.3	1.4	5.2	1.4	0.8	0.5	0.6	1.1	2.3	1.3	0.9	0.9	1.4	0.9
Wears glasses or contact lenses	0.3	0.4	1.7	0.6	0.1	1.1	-0.2	-0.2	0.7	-0.1	-0.4	-0.4	1.3	-0.3
Mother’s age at death	0.3	0.4	0.9	-0.2	-0.8	0.1	-0.4	0.8	0.6	1.0	0.7	0.8	0.3	0.3
Medication: Blood pressure	0.3	0.5	3.0	0.4	-0.2	0.6	0.9	0.1	-1.7	-0.9	0.2	0.2	0.1	-0.2
Medication: Atorvastatin	0.3	0.4	0.9	0.3	-0.0	-0.1	-0.5	-0.7	0.8	-0.5	-0.6	-0.6	-0.9	-0.7
Pain experienced in last month	0.3	0.5	2.5	0.0	0.5	-0.7	1.6	0.3	0.7	-0.3	0.3	0.3	-0.9	0.6
Pack years of smoking	0.3	0.4	2.0	1.2	0.2	0.6	-0.2	0.3	1.4	0.6	0.3	0.3	0.2	0.4
Depression (Nagel 2018)	0.2	0.3	1.3	-0.6	-0.6	-0.2	-0.8	-0.0	-0.2	0.1	0.1	0.1	-1.1	-0.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-0.9	-1.0	-0.7	1.1	-0.3	0.3	0.3	-0.3	-0.3	-1.1	-0.5
Schizophrenia (2018)	0.2	0.4	1.1	1.0	0.1	0.8	-0.3	0.1	0.8	-0.6	-0.0	-0.0	1.0	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	1.2	0.2	-0.1	-0.1	-1.1	0.3	0.8	0.4	0.3	0.3	0.3	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	1.4	0.2	0.2	0.6	0.2	-0.5	-1.2	0.1	-0.5	-0.5	0.9	-0.5
Mean Putamen Volume	0.2	0.3	1.3	-0.0	-0.3	-0.2	-0.0	-0.6	0.6	-0.5	-0.5	-0.5	-0.3	-1.2
Neuroticism (2016)	0.2	0.3	0.7	-0.2	-0.4	0.3	-0.8	-0.7	-0.2	-0.4	-0.6	-0.6	0.4	-0.7
Primary Biliary Cirrhosis	0.2	0.3	1.5	-1.2	-0.2	-0.8	0.1	-0.3	0.2	-0.3	-0.2	-0.2	-0.8	-0.1
Blood Eosinophil Count	0.2	1.3	5.0	-0.9	-0.3	-1.3	2.2	0.3	-1.4	-0.3	0.5	0.5	-1.9	0.4
Blood White Count	0.2	1.2	3.2	-0.2	-1.4	-1.2	1.2	-0.9	-1.6	-0.6	-0.7	-0.7	-1.8	-0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.2	1.5	0.1	1.1	-0.1	-0.5	1.4	0.8	-0.5	-0.5	1.5	-0.2
Smoking Status	0.2	0.5	1.3	0.8	0.6	1.1	-0.3	-0.2	-1.1	-0.2	-0.2	-0.2	1.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.3	1.5	-0.0	0.4	0.2	0.4	1.1	0.3	0.5	0.5	-0.0	0.3
Neuroticism	0.2	0.4	1.6	-1.3	0.4	-0.9	-0.9	0.6	0.2	0.5	0.5	0.5	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.9	-0.8	0.0	-0.5	-0.1	0.2	-0.1	0.4	0.3	0.2	-1.4	0.1
Pack years adult smoking proportion	0.2	0.4	1.1	1.0	0.1	0.8	-0.2	0.4	1.1	0.6	0.4	0.4	0.2	0.4
Trunk fat percentage	0.2	1.0	1.8	1.4	0.6	0.4	0.4	1.1	1.1	1.4	0.9	0.9	1.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	-0.8	-0.1	-0.6	-0.4	0.3	-0.2	0.6	0.4	0.4	-1.1	0.5
Age when periods started (menarche)	0.2	0.5	1.8	-1.0	-0.3	-0.6	-0.6	-0.1	-0.8	-0.9	-0.0	-0.0	-1.4	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	1.0	0.7	0.2	0.2	0.8	0.4	-1.0	-0.3	0.4	0.4	0.1	0.4
Stomach or abdominal pain in last month	0.2	0.2	1.0	-0.5	-0.7	1.0	-0.2	-0.4	0.0	0.2	-0.3	-0.3	0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.1	-0.4	-0.2	-0.4	0.1	-0.9	-0.1	0.2	0.2	-1.0	0.1
Leg predicted mass (left)	0.2	1.3	3.7	1.8	1.5	1.2	0.3	0.8	1.2	0.7	0.7	0.7	1.9	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	-0.1	-0.5	0.8	0.2	0.3	0.5	0.4	0.4	-0.8	0.3
Had menopause	0.2	0.2	0.6	-0.4	0.6	-0.6	0.8	0.4	0.6	-0.5	0.3	0.3	0.2	0.4
Fluid intelligence score	0.2	0.5	1.5	0.1	-1.1	-0.6	-0.6	-0.4	-1.2	-0.0	-0.5	-0.5	-0.5	-0.9
Impedance of arm (right)	0.2	1.1	8.3	-0.4	-0.8	-0.2	-0.9	-0.8	-2.9	-0.3	-0.7	-0.7	0.0	-0.8
Arm fat percentage (right)	0.2	0.6	2.0	1.0	0.1	-0.1	0.4	0.8	1.4	1.2	0.7	0.7	0.5	0.7
Hip circumference	0.2	1.0	4.0	1.3	0.3	1.2	0.2	0.6	2.0	0.3	0.5	0.5	1.7	0.3
Depression (self-reported)	0.2	0.3	0.8	-0.7	0.9	-0.2	-0.0	-0.1	0.8	0.7	-0.2	-0.2	-0.9	-0.1
Impedance of arm (left)	0.2	1.0	6.9	-0.7	-0.8	-0.3	-1.0	-0.7	-2.6	0.0	-0.7	-0.7	0.1	-0.6
Length of working week for main job	0.2	0.2	0.6	0.6	-0.3	0.5	-0.8	-0.5	-0.4	-0.1	-0.5	-0.5	-0.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.9	0.3	0.2	0.7	-0.6	-0.1	-0.7	-0.6	-0.6	0.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	2.7	1.6	0.9	0.8	-0.6	0.4	-0.4	0.1	0.4	0.4	1.4	0.6
Body fat percentage	0.2	0.7	1.9	1.3	0.2	0.3	0.6	0.9	1.4	1.1	0.7	0.7	0.7	0.6
Comparative body size at age 10	0.2	0.4	1.1	0.4	-0.5	0.1	0.6	-0.8	1.1	-0.1	-0.7	-0.7	-0.9	-0.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	-1.1	-1.1	0.1	0.2	-0.6	-0.8	-0.3	-0.5	-0.5	-0.6	-0.6
Qualifications: College or University degree	0.2	0.6	3.0	-0.9	-0.5	-0.8	-0.5	-0.3	-1.7	-0.4	-0.3	-0.3	-1.0	-0.4
Medication: Blood pressure	0.2	0.4	1.7	0.4	-0.0	0.2	-1.3	0.7	0.9	0.4	0.7	0.7	0.2	0.4
Leg fat mass (right)	0.2	0.8	3.0	1.6	0.3	0.9	0.5	0.7	1.7	0.5	0.5	0.5	1.1	0.3
Alcohol intake frequency.	0.2	0.5	0.8	-0.3	0.7	-0.5	-0.7	0.8	0.9	0.7	0.7	0.7	-0.7	0.8
Suffer from ‘nerves’	0.2	0.3	1.1	0.1	1.1	-0.4	0.5	0.2	0.8	1.0	0.1	0.1	-0.4	0.4
Had major operations	0.2	0.2	1.0	0.5	0.6	-0.9	-0.4	-0.2	1.0	0.2	-0.1	-0.1	-0.4	-0.0
Hypertension (Self-reported)	0.2	0.4	1.8	-0.9	-0.6	-0.8	0.0	0.3	-0.9	-0.0	0.4	0.4	-1.4	-0.2
Arm fat percentage (left)	0.2	0.6	2.2	0.8	0.1	-0.1	0.3	0.8	1.5	1.2	0.7	0.7	0.6	0.7
Ever had bowel cancer screening	0.2	0.2	0.9	0.0	-0.3	-0.3	0.7	-0.1	-0.1	-0.5	-0.1	-0.1	-0.9	-0.2
Friendships satisfaction	0.2	0.2	1.6	0.3	-0.1	-0.1	0.3	0.1	0.8	1.3	0.1	0.1	-0.0	-0.2
Medication for cholesterol	0.2	0.3	1.0	-0.7	0.4	0.2	-0.1	0.5	0.4	1.0	0.4	0.4	0.4	0.5
Breast cancer (self-reported)	0.2	0.2	1.0	-1.0	0.1	-0.5	0.6	-0.2	0.3	-0.3	-0.2	-0.1	-0.7	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	-0.9	-0.1	-0.8	-1.0	0.3	-0.5	0.3	0.2	0.2	-1.1	0.1
Number of operations (self-reported)	0.2	0.3	2.4	0.1	1.6	0.3	0.3	0.1	0.8	0.4	0.1	0.1	0.1	0.3
Average weekly beer plus cider intake	0.2	0.3	1.2	0.7	0.0	0.8	0.1	0.2	-1.1	-0.1	0.3	0.3	0.6	0.2
Risk taking	0.2	0.3	0.9	-0.0	-0.2	0.9	0.9	0.1	-0.7	0.5	0.1	0.1	0.7	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	2.5	0.4	0.4	0.5	-0.4	0.1	0.8	0.6	-0.0	0.0	1.6	0.5
Impedance of whole body	0.2	1.1	6.5	-0.6	-0.9	-0.1	-0.8	-0.9	-2.6	-0.6	-0.9	-0.9	-0.3	-1.0
Leg fat mass (left)	0.2	0.8	2.9	1.4	0.3	0.8	0.6	0.8	1.7	0.6	0.7	0.7	1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.4	1.4	-0.3	-0.7	-1.0	-0.1	0.4	-1.2	0.4	0.2	0.2	-0.8	0.0
Schizophrenia (2014)	0.1	0.2	1.0	0.5	-0.2	-0.2	-1.0	0.4	0.8	-0.4	0.3	0.3	0.1	-0.1
Hair Pigment	0.1	1.8	3.3	-0.2	1.7	-0.6	-1.2	1.8	0.9	1.4	1.7	1.7	0.6	1.8
Tanning	0.1	0.8	2.7	-1.6	-0.4	-0.8	1.6	-0.7	-0.7	-0.7	-0.6	-0.6	-0.6	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.7	-0.2	-0.4	-0.1	0.0	-0.3	-0.2	0.0	0.0	-0.1	-0.1
High blood pressure	0.1	0.3	1.7	-0.7	-0.2	-0.8	0.2	0.3	-0.5	-0.2	0.4	0.4	-1.3	-0.2
Medication: Levothyroxine sodium	0.1	0.2	1.1	0.7	-0.5	0.0	-0.2	-0.2	0.2	0.4	-0.2	-0.2	-1.0	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.6	0.1	0.5	0.2	-0.4	-0.0	0.4	-0.4	-0.4	0.3	-0.3
Number of incorrect matches in round	0.1	0.2	0.7	0.0	0.2	-0.1	0.8	0.2	-0.8	0.6	0.3	0.3	0.4	0.4
Had other major operations	0.1	0.1	0.5	-0.1	0.4	0.7	0.1	0.0	-0.2	0.0	-0.1	-0.1	0.5	-0.0
Forced vital capacity (FVC)	0.1	0.4	1.0	0.9	1.0	0.8	-0.7	0.1	-0.3	-0.4	0.2	0.2	1.0	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.9	-0.1	1.0	0.3	-0.4	0.4	0.3	0.1	0.4	0.4	-0.3	0.6
Father’s age at death	0.1	0.1	0.4	0.7	-0.3	0.5	0.2	0.1	-0.1	-0.3	0.2	0.2	0.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.6	0.4	0.2	-0.8	-0.3	-0.9	-0.9	-0.2	-0.2	0.0	-0.2
Pulse rate	0.1	0.2	1.2	-0.3	1.1	0.0	0.3	0.1	-0.6	0.1	0.1	0.1	0.1	0.4
Medication: Lansoprazole	0.1	0.2	0.3	-0.5	0.5	-0.1	-0.2	0.5	-0.3	-0.4	0.5	0.5	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.4	1.2	0.1	0.1	-0.8	-0.1	-0.8	-0.3	0.0	0.0	0.2	0.2
Peak expiratory flow (PEF)	0.1	0.3	1.1	0.6	-0.5	0.7	-0.2	0.1	-1.1	-0.6	0.2	0.2	0.5	-0.1
Pulse wave reflection index	0.1	0.1	0.3	0.4	-0.4	0.6	0.5	0.1	0.6	0.3	0.1	0.1	0.2	0.0
Leg fat percentage (right)	0.1	0.4	2.0	1.1	-0.9	0.4	0.0	0.3	1.4	0.3	0.1	0.1	0.1	-0.1
Number of full brothers	0.1	0.1	0.4	0.1	-0.4	0.5	-0.6	0.0	-0.6	0.1	-0.1	-0.1	0.4	-0.1
Eye problems/disorders: None of the above	0.1	0.2	0.5	-0.7	0.1	0.2	0.7	-0.3	-0.1	-0.5	-0.4	-0.4	0.3	-0.3
Back pain experienced in last month	0.1	0.1	0.3	0.2	-0.3	0.4	-0.1	-0.1	0.3	-0.4	-0.1	-0.1	0.6	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.1	0.1	0.7	-0.6	0.4	0.3	0.2	0.2	0.2	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.7	0.2	-0.3	-0.0	-0.1	-0.4	0.2	-0.5	-0.5	-0.5	-0.6	-0.8
Leg fat percentage (left)	0.1	0.5	2.2	1.1	-0.7	0.4	0.3	0.6	1.5	0.5	0.4	0.4	-0.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.8	-0.4	-0.4	-0.0	0.9	-0.2	0.7	-0.1	-0.2	-0.1	0.1	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.4	0.4	0.1	-0.4	0.0	0.2	0.7	-0.5	0.1	0.1	-0.3	-0.2
Lung FVC	0.0	0.2	0.6	-0.1	0.3	-0.8	-0.2	0.3	-0.5	0.4	0.4	0.4	-0.4	0.7
Number of treatments/medications taken	0.0	0.1	0.2	0.2	-0.5	0.3	-0.4	-0.0	0.0	-0.3	-0.1	-0.1	-0.4	-0.1
Ever smoked	0.0	0.1	0.4	-0.1	0.7	0.1	-0.5	0.2	-0.1	-0.2	0.1	0.1	0.3	0.1

Hub : Genes

TRIM5

Models

Trait associations