Hub : Genes

TRIM6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.1574	0.0417	2.0e-13	0.148	0.138	0.149	NA	0.149	2.5e-16	2.9e-15	1.8e-16	NA	1.9e-16
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1330	0.0580	3.1e-04	0.024	0.069	0.077	NA	0.045	1.5e-02	8.7e-05	3.6e-05	NA	1.3e-03
3	TCGA	Lung Adenocarcinoma	0.0425	0.0196	2.8e-03	0.009	0.015	0.012	NA	0.012	2.8e-02	6.3e-03	1.3e-02	NA	1.1e-02
4	TCGA	Prostate Adenocarcinoma	0.1418	0.0581	4.3e-03	-0.002	0.026	0.008	NA	-0.002	5.9e-01	7.9e-04	4.4e-02	NA	7.7e-01
5	TCGA	Thyroid Carcinoma	0.4710	0.0790	1.4e-14	0.238	0.168	0.238	NA	0.241	5.3e-23	3.8e-16	5.2e-23	NA	3.2e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	1.6	0.5	0.5	-0.9	1.3	1.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	0.2	0.5	0.3	1.2	-0.8
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-1.5	-0.9	-0.1	-0.0	0.0
Depression (Nagel 2018)	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.9	1.6	1.6	-1.0	-1.2	-1.7
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-1.2	-0.6	-0.3	0.3	0.1
Schizophrenia (2018)	0.5	1.1	3.7	-0.2	0.3	1.1	0.6	-1.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.3	-0.1	0.7	0.8	0.1
Worry (Nagel 2018)	0.3	0.5	1.8	-1.3	-0.7	-0.3	-0.6	-0.0
Alzheimer’s Disease (in mother)	0.6	0.7	2.1	-1.0	0.0	0.4	0.6	-1.5
Alzheimer’s Disease (in father)	1.3	1.4	4.1	-0.7	-0.8	2.0	0.2	1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.9	-0.3	0.9	0.2	-0.1
Crohns Disease (2017)	0.8	1.8	4.1	2.0	1.6	-0.8	0.5	1.1
Irritable Bowel Disease (IBD)	0.9	2.1	5.2	2.3	2.2	0.3	0.0	-0.4
Ulcerative Colitis (UC)	1.4	2.6	5.0	2.0	2.2	0.9	-0.7	-1.5
Major Depression (MDD)	1.3	1.6	6.2	0.6	0.7	-2.5	0.0	1.0
Reaction Time	0.4	0.7	2.4	0.6	0.7	1.6	-0.1	-0.5
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.2	1.5	2.0	-0.6	-1.4	-1.7
Breast Cancer	0.9	2.2	7.2	-0.8	-1.7	-0.5	0.1	2.7
Ovarian Cancer	1.4	1.9	4.0	-1.5	-2.0	-0.6	-0.6	1.5
Prostate Cancer	0.7	0.9	3.6	-0.4	0.2	1.9	0.2	-0.9
Age at First Birth	0.1	0.2	0.6	-0.4	-0.1	-0.8	0.3	0.1
Bipolar Disorder (2011)	0.9	0.9	2.0	0.6	1.1	-0.6	1.4	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.6	-0.3	0.3	0.5	-1.0
Coronary Artery Disease (CAD)	1.1	1.3	2.9	-1.2	-1.7	0.2	0.7	1.2
Crohns Disease (2012)	0.4	0.6	1.3	0.6	0.9	-0.4	0.6	1.1
Mean Putamen Volume	0.5	0.6	1.7	1.3	0.5	-0.6	0.3	-0.7
Fasting Glucose	0.2	0.3	1.0	-0.0	0.4	0.5	-1.0	0.1
HbA1C	1.8	2.0	4.4	0.5	0.9	2.1	1.9	-0.9
HDL Cholesterol	0.4	0.7	1.8	-1.0	-0.2	1.3	0.7	0.1
LDL Cholesterol	0.9	1.4	5.4	0.2	0.3	-2.3	-1.1	-0.6
Lupus	0.9	1.4	4.0	-1.0	-0.8	2.0	1.1	-0.6
Neuroticism (2016)	0.7	1.0	2.8	-1.4	-1.7	-0.0	0.0	0.6
Primary Biliary Cirrhosis	0.6	0.9	3.0	0.1	0.3	-1.2	0.0	1.7
Rheumatoid Arthritis	1.5	2.1	5.6	-0.6	-1.2	-2.4	-0.7	1.6
Schizophrenia (2014)	0.2	0.5	1.3	0.6	1.1	-0.1	0.5	-0.9
Triglycerides	1.0	1.6	5.2	0.8	0.8	0.8	-2.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	-0.7	-0.8	-0.6	-0.2	0.8
Ulcerative Colitis	1.0	1.4	3.1	0.6	1.3	0.4	1.7	-1.3
Blood Eosinophil Count	0.1	1.0	1.5	-0.9	-1.2	-1.0	1.2	0.5
Blood Platelet Count	1.0	11.5	49.3	1.7	2.1	7.0	0.9	-0.5
Blood Red Count	0.6	5.9	12.8	-3.6	-2.8	-0.1	-0.6	3.0
Blood White Count	0.1	0.7	2.8	-0.5	-0.6	-0.3	0.4	1.7
Heel T-Score	0.1	0.6	1.3	1.1	0.9	0.9	0.0	0.2
BMI	0.6	3.5	7.3	2.7	2.5	-0.7	-1.6	-0.9
Height	0.3	5.1	10.8	1.8	2.8	3.3	-1.6	-1.1
Waist Hip Ratio (WHR)	0.0	0.2	0.7	-0.4	-0.1	0.8	0.1	0.3
Systolic Blood Pressure	0.4	1.9	3.8	0.8	0.4	-1.9	-1.1	1.9
Smoking Status	0.5	1.2	4.1	-0.5	-0.4	2.0	1.2	-0.5
Allergy or Eczema	0.2	0.6	1.3	0.1	0.5	1.1	-0.5	1.1
Cardiovascular Disease	0.5	1.6	2.9	1.7	1.4	-1.1	-0.1	-1.4
Hypothyroidism (self reported)	0.5	1.1	3.3	1.8	1.4	-0.5	0.5	0.2
Respiratory disease	0.5	1.1	1.8	1.3	1.1	-0.2	0.7	1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.7	-0.4	-1.0	-1.7	0.8	0.9
Lung FEV1/FVC ratio	0.1	0.4	0.7	-0.6	-0.3	-0.8	-0.8	-0.2
Lung FVC	0.7	3.7	5.8	-2.4	-2.3	2.1	1.6	0.9
Neuroticism	0.4	1.0	2.2	-0.8	-0.7	-0.3	-1.5	1.3
Chronotype (morning person)	0.3	0.6	1.4	1.1	1.2	-0.3	-0.4	0.5
Hair Pigment	0.1	1.8	6.9	-0.7	-0.5	2.6	-0.9	-0.8
Tanning	0.2	2.2	6.3	2.5	1.7	-0.9	0.9	0.2
Hand grip strength (left)	0.6	1.5	6.3	-0.1	1.0	2.5	-0.3	-0.1
Number of treatments/medications taken	0.2	0.4	1.0	0.2	0.1	-0.8	-1.0	-0.4
Average weekly spirits intake	0.4	0.4	1.1	-0.8	-0.5	0.2	-1.0	-0.4
Sensitivity / hurt feelings	1.0	1.7	4.7	2.2	1.5	-1.0	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.6	0.4	-0.4	-0.8	0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.2	0.9	0.1	-1.1	-0.6	-0.2
Relative age of first facial hair	0.6	1.2	4.1	0.5	0.0	0.1	1.2	2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-0.5	-1.1	-0.8	-1.0	0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	1.5	1.1	-0.7	0.5	-1.0
Ever had hysterectomy (womb removed)	1.5	1.7	4.8	1.3	1.3	0.6	0.5	-2.2
Systolic blood pressure, automated reading	0.7	2.0	3.5	1.5	0.7	-1.1	-1.9	1.5
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	8.5	-0.1	0.2	0.9	2.9	-0.2
Angina	0.3	0.5	1.1	0.8	0.1	-1.1	-0.3	0.6
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.5	-0.6	0.9	-0.8	-0.2
Vitamin and mineral supplements	0.6	0.8	1.9	1.1	0.9	-0.3	0.3	-1.4
Supplements: Zinc	0.5	0.6	1.2	-0.7	-0.5	0.7	1.1	-0.6
Medication: Co-codamol	0.1	0.2	0.4	0.3	0.6	-0.3	-0.1	-0.4
Medication: Metformin	0.4	0.6	2.7	-0.2	0.1	0.3	1.6	-0.2
Diabetes (father)	0.2	0.2	0.8	-0.0	0.1	0.5	-0.1	-0.9
Diabetes (mother)	0.1	0.1	0.3	-0.4	-0.0	-0.2	-0.5	0.1
Severe depression (siblings)	1.0	1.1	2.9	0.3	0.8	1.7	-1.1	-0.8
Pack years adult smoking proportion	0.2	0.2	0.6	-0.6	-0.5	0.1	0.2	0.8
Impedance of leg (right)	0.6	2.8	6.3	-2.5	-2.3	0.0	1.2	-1.0
Leg fat-free mass (left)	0.8	4.0	8.1	2.7	2.8	0.4	-2.1	0.3
Trunk fat percentage	0.8	3.3	4.8	1.9	2.0	-0.8	-2.2	-1.8
Hand grip strength (right)	0.4	1.0	3.1	0.3	1.2	1.8	-0.3	-0.1
Townsend deprivation index at recruitment	0.3	0.5	1.1	-0.1	-0.6	-0.7	-0.7	1.0
Current tobacco smoking	0.3	0.4	1.3	-0.2	-0.2	1.1	0.4	-0.8
Average weekly fortified wine intake	0.6	0.7	2.2	-0.6	-0.6	0.4	-1.5	-0.6
Maternal smoking around birth	1.1	1.6	3.2	0.8	0.9	1.6	0.9	-1.8
Fed-up feelings	0.5	0.8	2.5	-0.6	-0.3	-1.1	-1.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	-0.1	-0.2	0.3	-0.6	-0.3
Relative age voice broke	0.8	1.3	4.9	-0.5	-0.3	0.6	1.0	2.2
Taking other prescription medications	0.9	1.4	6.1	0.5	-0.4	-0.3	-2.5	0.7
Age when periods started (menarche)	0.4	1.0	4.2	-0.0	-0.8	-0.3	2.0	-0.5
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	5.2	1.4	1.4	0.5	0.4	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.2	0.7	0.5	1.5	0.9	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.7	0.2	0.0	-0.6	-0.1	1.6
Qualifications: CSEs or equivalent	0.6	0.7	1.4	0.5	0.9	1.1	1.2	-0.2
Serious illness, injury or assault to yourself	0.4	0.4	1.9	0.0	-0.2	-0.5	-1.4	0.1
High blood pressure	0.7	2.0	3.3	1.7	1.8	-1.0	-1.1	-1.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.1	0.5	0.5	-0.9	0.9
Multivitamins +/- minerals	0.3	0.4	0.9	0.4	0.6	-0.9	-0.4	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.7	-0.8	-1.1	0.0	-0.2
Supplements: Glucosamine	0.4	0.5	2.0	0.4	0.4	1.4	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.5	0.1	-0.0	-0.6	0.8
Medication: Atenolol	1.7	2.2	5.5	1.5	1.6	0.4	0.7	-2.3
Medication: Levothyroxine sodium	0.8	1.3	2.9	0.7	0.5	-0.9	-1.7	1.4
Sitting height	0.1	0.9	2.0	1.1	1.4	0.8	-0.8	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.7	0.5	-0.0	0.2	-1.5
High blood pressure (mother)	1.2	1.6	5.3	-0.1	-1.1	-0.4	-2.3	1.2
Body mass index (BMI)	0.8	3.3	4.7	2.1	2.0	-1.6	-2.2	-0.6
Impedance of leg (left)	0.8	3.8	8.2	-2.9	-2.6	0.5	1.4	-1.3
Leg predicted mass (left)	0.7	3.9	8.1	2.7	2.8	0.4	-2.1	0.3
Trunk fat mass	1.0	4.1	6.4	2.4	2.5	-0.6	-2.5	-1.4
Waist circumference	1.2	4.5	8.2	2.8	2.9	-1.1	-1.8	-1.4
Number of incorrect matches in round	0.3	0.5	1.0	0.7	0.8	0.4	1.0	-0.3
Past tobacco smoking	0.2	0.3	1.3	0.4	0.2	-1.1	-0.2	-0.3
Alcohol usually taken with meals	0.2	0.3	0.6	0.5	0.5	-0.8	0.6	0.1
Nervous feelings	0.2	0.4	0.8	-0.8	-0.5	0.4	-0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	0.3	1.0	-0.2	-1.3	-1.1
Hearing difficulty/problems with background noise	0.5	0.9	2.0	-0.8	-1.0	-0.8	0.0	1.4
Hair/balding pattern: Pattern 2	0.8	1.0	2.4	1.2	1.1	-0.4	0.3	1.5
Had menopause	1.4	1.8	4.2	0.8	-0.2	-1.9	-2.0	-0.7
Had other major operations	0.8	1.0	2.0	-1.3	-1.4	0.3	-0.3	1.2
Forced vital capacity (FVC)	0.2	0.9	3.1	-1.0	-0.4	1.8	-0.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.6	0.5	0.1	1.6	0.8	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.2	-1.5	-1.1	0.1	1.0	-0.9
Qualifications: None of the above	1.3	2.7	8.4	0.5	-0.3	-2.9	-1.8	1.3
Financial difficulties in last 2 years	1.8	2.4	4.1	-2.0	-1.9	1.9	-0.0	0.6
Mouth/teeth dental problems	0.6	0.9	3.5	-0.2	0.6	0.5	1.9	-0.7
Heart attack	1.4	1.8	7.2	0.9	0.7	-2.7	-0.6	0.5
Allergy	0.4	0.9	2.5	-0.2	-0.8	-0.0	1.2	-1.6
Pain all over the body in last month	0.9	0.9	1.6	0.2	0.7	1.2	1.1	-1.2
Diabetes (self-reported)	0.4	0.7	1.4	0.2	-0.4	-1.2	0.6	1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.5	1.3	1.6	-1.5	-1.3	0.1
Medication: Ramipril	1.6	2.1	4.6	1.6	0.7	-1.5	-0.6	2.2
Medication: Simvastatin	1.2	1.8	3.8	1.1	0.5	-1.9	-2.0	-0.5
Fluid intelligence score	1.8	3.6	7.1	2.0	2.6	0.0	-0.8	-2.7
Illnesses of siblings	0.1	0.1	0.1	0.3	0.3	-0.1	0.4	0.3
Neuroticism score	0.3	0.6	2.7	0.1	0.4	-0.6	-1.6	0.1
Weight	0.8	4.1	7.1	2.5	2.7	-0.4	-2.5	-0.9
Impedance of arm (right)	0.2	1.0	2.3	-1.2	-0.9	0.5	0.6	-1.5
Arm fat percentage (right)	0.7	2.6	3.9	1.7	1.8	-1.4	-2.0	-1.2
Trunk fat-free mass	0.4	2.0	3.6	1.6	1.7	0.6	-1.9	0.9
Hip circumference	1.0	4.2	7.3	2.5	2.7	-0.7	-2.1	-1.6
Time employed in main current job	0.1	0.1	0.4	0.1	-0.2	-0.1	0.7	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.3	0.0	-0.2	-1.1	0.3	1.1
Father’s age at death	1.5	2.0	4.1	-1.5	-1.9	0.2	-2.0	0.2
Worrier / anxious feelings	0.2	0.4	1.9	-0.2	0.1	-0.3	-1.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	1.2	1.1	-1.2	-0.2	-0.2
Falls in the last year	0.1	0.1	0.2	0.5	0.4	0.2	-0.1	0.1
Hair/balding pattern: Pattern 3	1.9	2.9	5.4	-2.1	-2.3	-1.3	-0.5	1.6
Number of live births	0.3	0.4	0.6	0.2	-0.6	0.7	-0.8	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.8	-0.5	0.3	1.4	-0.2	-0.7
Pulse rate	0.3	0.5	1.2	-0.4	-1.1	-0.4	-0.6	0.9
Happiness	1.7	2.1	4.3	-0.5	-0.6	-1.7	-1.6	2.1
Noisy workplace	2.0	2.5	4.4	-2.1	-1.6	1.8	-0.4	1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.5	-0.6	0.3	0.6	1.2	-2.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	-0.4	-0.5	0.4	-1.5	0.7
Mouth/teeth dental problems: Dentures	0.8	1.3	4.2	-0.4	-1.1	-0.3	-2.0	1.0
Asthma	1.0	2.0	6.0	1.3	0.8	-0.9	-1.0	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.1	-0.5	-0.3	0.2	-0.6
Medication: Cholesterol lowering	0.3	0.5	1.5	0.6	0.4	-1.2	0.2	0.4
Depression (self-reported)	0.3	0.4	0.9	0.4	0.6	0.3	0.6	-0.9
Medication: Lansoprazole	0.3	0.4	0.8	0.6	0.2	-0.6	-0.6	-0.9
Prospective memory result	0.6	0.7	1.3	-1.1	-0.9	0.3	-0.4	1.2
Lung cancer (father)	1.4	1.6	5.4	1.2	1.0	-0.2	-2.3	0.1
Illnesses of mother	0.6	0.7	2.4	0.2	0.8	0.7	1.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.2	-0.5	-0.1	1.8	0.3	0.1
Pulse wave Arterial Stiffness index	0.9	1.1	2.7	1.6	1.6	-0.6	0.2	-0.0
Impedance of arm (left)	0.3	1.2	2.3	-1.5	-1.2	0.6	0.5	-1.3
Arm fat mass (right)	0.7	2.8	5.6	1.9	2.0	-0.7	-2.4	-0.8
Trunk predicted mass	0.3	1.9	3.3	1.5	1.6	0.7	-1.8	1.0
Standing height	0.2	1.9	5.6	0.7	1.2	2.4	-1.1	-0.6
Length of working week for main job	0.6	0.7	1.6	0.5	0.6	1.3	1.1	-0.4
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.5	0.5	0.5	-0.3	0.5
Breastfed as a baby	1.8	2.2	4.8	1.6	0.7	-2.2	-1.7	0.8
Tense / ‘highly strung’	0.9	1.5	5.3	0.7	0.2	-2.3	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.8	-0.4	-0.6	-1.1	-1.7	1.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.4	0.6	0.3	0.0	0.3	-0.1
Birth weight of first child	1.2	2.2	5.7	-2.0	-1.1	0.2	2.4	0.6
Peak expiratory flow (PEF)	0.3	0.8	1.7	-1.0	0.4	1.3	-1.0	-0.4
Pulse wave reflection index	0.1	0.1	0.3	-0.2	0.5	0.1	0.6	-0.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.3	0.7	1.3	1.7	0.7	-2.1
Loud music exposure frequency	2.2	2.4	9.4	0.8	0.5	-3.1	0.9	1.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	6.0	0.2	1.0	1.0	1.5	-2.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.8	2.0	1.7	-1.1	0.1	-0.7
Blood clot in the leg (DVT)	1.3	1.6	3.2	1.8	1.4	-0.1	-1.6	0.5
Medication: Paracetamol	0.2	0.4	1.0	-1.0	-0.5	-0.3	-0.1	-0.8
Headache pain in last month	1.1	1.8	4.5	2.1	1.8	-0.6	-0.9	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.5	-0.4	0.9	0.5	-0.5
Glaucoma (self-reported)	0.7	0.9	1.9	-0.7	-0.2	1.4	1.0	-1.0
Gout (self-reported)	1.2	1.7	3.1	1.0	0.9	1.7	-1.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.3	1.1	0.8	-0.3	-0.8	0.4
Medication: Amlodipine	0.2	0.3	1.2	0.1	-0.1	-1.1	0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.3	0.1	-0.4	-0.2	-0.5	1.8
Birth weight	0.3	0.6	1.1	0.4	-0.3	-1.0	0.9	1.1
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.4	-0.3	-0.2	-0.6	0.4
High blood pressure (siblings)	0.4	0.6	1.4	-0.7	-0.7	-0.7	-1.2	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	4.9	-0.5	-0.3	2.2	0.5	0.6
Body fat percentage	0.7	2.9	3.6	1.7	1.8	-1.3	-1.9	-1.7
Leg fat percentage (right)	0.6	2.3	3.8	1.2	1.2	-1.9	-2.0	-1.0
Arm fat-free mass (right)	0.4	1.9	3.4	1.6	1.8	0.4	-1.9	0.5
Exposure to tobacco smoke outside home	0.6	0.8	2.1	-0.9	-0.3	0.9	-1.4	0.4
Comparative body size at age 10	0.2	0.4	1.2	0.2	0.7	0.3	1.1	-0.4
Number of full brothers	0.3	0.3	0.6	0.6	0.6	-0.8	-0.5	0.5
Worry too long after embarrassment	0.2	0.3	0.7	0.7	0.5	-0.0	0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.1	-0.0	-0.0	-1.3	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	2.1	1.0	0.7	-1.4	-0.5	1.2
Number of children fathered	0.9	1.0	1.5	0.4	1.2	1.1	-1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.6	1.4	0.7	0.8	-1.6	-0.5
Age at first live birth	0.2	0.4	1.0	-0.2	-0.1	0.1	-1.0	1.0
Pulse wave peak to peak time	0.8	1.0	2.1	-1.4	-1.3	0.8	-0.5	-0.3
Health satisfaction	2.3	3.0	10.8	0.3	-0.2	-3.3	0.8	1.9
Shortness of breath walking on level ground	0.3	0.3	1.4	-0.3	0.1	-0.4	-1.2	0.1
Qualifications: College or University degree	0.8	2.6	9.6	-1.4	-0.6	1.1	3.1	0.1
Eye problems/disorders: None of the above	0.4	0.5	2.0	0.3	0.1	-1.4	-0.2	0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.2	0.0	-1.5	-1.2	-0.5	1.4
Emphysema/chronic bronchitis	0.6	0.7	2.0	-0.7	-1.4	0.2	1.0	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	0.1	0.6	1.1	-0.1	0.2
Neck or shoulder pain in last month	0.1	0.1	0.6	-0.2	-0.1	0.1	-0.2	-0.8
Medication: Blood pressure	0.1	0.2	0.8	-0.0	0.2	-0.2	-0.9	0.1
Angina (self-reported)	0.3	0.4	0.9	0.9	0.2	-1.0	-0.4	0.5
Migraine (self-reported)	0.4	0.5	1.3	0.4	-0.0	1.1	-1.0	-0.4
Medication: Ibuprofen	0.4	0.5	1.5	0.0	-0.9	-1.2	0.4	0.0
Medication: Allopurinol	2.5	3.3	7.1	1.9	2.0	0.9	-2.7	-1.2
Medication: Omeprazole	0.4	0.5	0.9	1.0	0.7	-0.6	-0.8	0.4
Medication: Seretide 50 evohaler	0.9	1.1	3.9	-0.5	-0.4	0.4	-2.0	0.9
Mean time to correctly identify matches	0.1	0.2	0.3	0.6	0.3	0.3	-0.5	0.4
Heart disease (mother)	1.7	2.1	6.6	-1.0	-1.5	-2.6	-0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	0.8	1.3	0.1	1.3	-1.4
Whole body fat mass	0.9	3.6	5.3	2.3	2.3	-0.8	-2.3	-1.3
Leg fat mass (right)	0.9	3.5	5.7	2.2	2.1	-1.0	-2.4	-1.2
Arm predicted mass (right)	0.4	1.9	3.5	1.6	1.7	0.5	-1.9	0.5
Pulse rate, automated reading	0.2	0.8	1.8	0.5	-0.4	-1.4	-1.3	0.2
Alcohol intake frequency.	0.2	0.4	1.3	0.0	-0.4	-1.1	0.5	0.4
Comparative height size at age 10	0.9	5.1	8.4	2.8	2.9	1.9	-1.9	-1.3
Number of full sisters	0.6	0.8	1.3	-1.1	-1.0	0.9	0.8	-0.0
Suffer from ‘nerves’	0.4	0.7	1.3	-1.0	-0.0	0.3	-1.1	-1.0
Overall health rating	1.0	2.2	5.9	1.4	1.0	-2.4	-0.7	-1.4
Chest pain or discomfort	0.2	0.3	1.5	-0.1	0.0	-0.4	0.3	1.2
Had major operations	0.5	0.6	1.4	0.9	0.5	0.2	0.5	1.2
Age at last live birth	0.3	0.4	0.8	0.3	0.6	0.9	-0.9	-0.2
Family relationship satisfaction	1.2	1.5	2.7	1.6	0.9	-0.3	-1.6	1.2
Leg pain on walking	0.6	0.8	2.6	0.4	0.5	-1.6	0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.0	-1.7	-1.6	0.4	1.3	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	1.2	0.4	-0.7	0.4	1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	-0.3	0.5	1.3	1.1	-0.8
Medication: Aspirin	0.8	1.0	1.7	0.2	-0.8	-1.2	1.1	1.3
Supplements: Vitamin C	2.3	2.7	7.0	-1.9	-2.6	0.9	-0.2	1.5
Knee pain experienced in last month	0.3	0.5	0.9	-0.7	0.3	-0.2	1.0	-1.0
Hypertension (Self-reported)	0.6	1.5	2.7	1.6	1.6	-1.1	-0.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.0	-0.5	-0.3	-0.5	0.5
Illnesses of father: Heart disease	1.5	2.1	4.4	-1.3	-1.4	-1.5	2.1	0.3
Illnesses of siblings: Diabetes	1.7	2.1	4.8	2.2	1.4	-1.1	-0.1	1.6
Smoking status: Previous	0.3	0.5	0.8	-0.6	-0.8	0.6	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	0.5	0.1	1.1	0.8	1.5
Whole body fat-free mass	0.5	2.7	4.7	2.0	2.2	0.5	-2.0	0.6
Leg fat-free mass (right)	0.7	3.7	7.7	2.5	2.8	0.8	-1.9	0.2
Arm fat percentage (left)	0.7	2.8	4.8	1.7	1.8	-1.3	-2.2	-1.1
Average weekly red wine intake	0.1	0.1	0.4	0.3	0.2	-0.6	-0.0	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	4.0	-0.3	0.2	0.5	2.0	-0.0
Mood swings	0.3	0.5	0.9	-0.7	-1.0	-0.5	-0.6	0.6
Loneliness, isolation	0.6	0.8	1.6	-1.2	-1.0	0.4	-0.6	-0.8
Long-standing illness, disability or infirmity	0.4	0.7	2.4	-0.5	-0.5	-0.2	-1.6	-0.6
Ever had bowel cancer screening	0.8	0.9	2.1	-0.3	-0.9	-1.5	-1.2	0.5
Diabetes diagnosed by doctor	0.2	0.4	1.1	-0.2	-0.3	-0.4	1.0	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.7	0.4	0.7	1.6	1.1	-0.6
Friendships satisfaction	0.5	0.6	1.6	0.9	1.3	-0.7	0.3	-0.2
Qualifications: nursing, teaching	0.4	0.6	1.5	0.9	0.4	-0.2	-0.6	1.2
Commuting to job workplace: Walk	0.1	0.2	0.3	-0.3	0.1	0.0	0.6	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	0.2	0.1	-0.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.0	-0.8	-1.4	0.4	-2.0	1.0
Medication for cholesterol	1.6	2.5	8.9	-1.1	-0.9	0.5	3.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.9	0.7	-0.2	0.5	-0.0
Back pain experienced in last month	0.6	0.9	1.4	-0.9	-1.2	0.4	1.0	-1.0
Mineral and other dietary supplements	0.7	1.0	2.5	0.2	0.0	-1.5	1.6	0.1
Breast cancer (self-reported)	1.1	1.3	1.9	-1.3	-0.8	0.9	-1.3	-1.4
Asthma (self-reported)	1.0	2.0	6.7	1.2	0.9	-0.7	-0.7	2.6
Osteoporosis (self-reported)	1.8	2.3	7.9	-0.4	-0.9	-2.8	-1.2	1.0
Osteoarthritis (self-reported)	0.7	1.0	1.9	1.3	1.4	0.1	-0.6	-0.9
Medication: Aspirin	0.8	1.0	1.7	-0.3	-1.1	-1.3	0.8	1.2
Medication: Gliclazide	1.6	1.8	4.4	-1.9	-2.1	-0.3	1.0	0.1
Illnesses of father: None of the above (group 1)	1.0	1.3	3.1	1.0	0.7	-1.3	-1.8	0.4
Smoking status: Current	0.3	0.5	1.2	-0.0	0.0	1.1	0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	-1.3	-0.8	0.7	1.0	0.6
Whole body water mass	0.5	2.8	4.9	2.1	2.2	0.5	-2.0	0.7
Leg predicted mass (right)	0.7	3.6	7.7	2.5	2.8	0.9	-1.8	0.2
Arm fat mass (left)	0.9	3.8	7.7	2.2	2.2	-1.1	-2.8	-0.7
Number of self-reported non-cancer illnesses	0.4	0.7	2.2	-0.3	-0.7	0.1	-1.5	0.8
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-0.9	-1.0	-1.5	0.1	1.3
Miserableness	0.2	0.3	0.9	-1.0	-0.1	-0.6	-0.2	-0.6
Guilty feelings	0.4	0.5	1.2	-0.7	-0.1	0.8	-1.1	0.6
Wears glasses or contact lenses	1.8	2.0	6.8	1.5	1.1	-0.1	-2.6	0.1
Ever taken oral contraceptive pill	1.4	1.5	3.3	-1.8	-1.0	0.6	1.7	-0.5
Hearing aid user	0.4	0.5	1.8	-0.2	-0.2	-0.7	-0.2	-1.4
Mother’s age at death	2.3	2.9	6.8	-2.2	-2.6	-0.6	-1.3	0.9
Financial situation satisfaction	1.2	1.4	3.5	0.4	-0.1	-1.2	1.5	1.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	-0.9	-0.6	-1.6	-0.3	-1.6
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.3	0.1	0.6	-0.5	0.5
Eye problems/disorders: Glaucoma	1.3	1.5	3.4	-0.1	0.1	1.8	1.5	-1.4
Medication: Blood pressure	0.7	1.3	2.1	1.4	1.2	-0.7	-1.3	-0.9
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.0	-1.4	-1.2	-0.8	-1.4	0.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.8	0.6	0.6	0.6	-2.2	-0.2
High cholesterol (Self-reported)	0.3	0.5	1.1	-0.2	-0.6	-0.9	-1.1	0.4
Medication: Bendroflumethiazide	0.5	0.7	1.0	0.8	1.0	1.0	-0.6	-0.9
Medication: Paracetamol	0.3	0.5	1.1	-1.0	-0.6	-0.5	0.4	-0.8
Medication: Lisinopril	0.6	0.8	2.6	-0.9	-0.2	0.4	0.5	-1.6
Medication: Atorvastatin	0.1	0.1	0.4	-0.6	0.1	-0.3	0.1	-0.4
Illnesses of father: High blood pressure	0.2	0.3	0.7	0.0	0.0	0.8	0.3	-0.7
Alcohol drinker status: Never	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.5	0.6
Ever smoked	0.4	0.6	3.0	-0.0	0.3	1.7	0.2	-0.2
Basal metabolic rate	0.5	3.0	5.3	2.1	2.3	0.5	-2.2	0.3
Leg fat percentage (left)	0.5	2.0	3.3	1.1	1.1	-1.7	-1.8	-1.2
Arm fat-free mass (left)	0.4	1.9	3.7	1.6	1.7	0.1	-1.9	0.4
Number of operations (self-reported)	0.2	0.3	1.5	-0.1	-1.2	0.0	0.0	0.3
Average weekly beer plus cider intake	0.2	0.4	0.7	0.4	0.6	0.9	0.5	-0.5
Irritability	0.1	0.1	0.3	0.2	-0.5	-0.1	-0.5	0.4
Risk taking	1.3	1.9	5.1	-0.7	-0.8	2.3	1.9	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	-0.1	-0.9	-0.4	-0.5	0.5
Fractured/broken bones in last 5 years	0.6	0.7	2.2	-0.7	-0.9	0.5	-1.5	-0.1
Age started oral contraceptive pill	0.8	1.0	1.4	-1.2	-1.0	0.9	-1.2	-0.9
Diastolic blood pressure, automated reading	0.3	0.9	2.4	0.8	0.9	0.8	-1.5	-0.3
Ever depressed for a whole week	0.5	0.6	0.7	0.8	0.8	-0.8	-0.4	-0.8
Unable to work because of sickness or disability	2.2	2.8	6.9	2.6	2.3	-0.9	-0.6	-0.9
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.8	-0.1	0.3	0.5	0.2
Myopia	0.4	0.6	1.1	0.5	1.1	1.0	0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.6	-1.3	-1.2	1.1	1.2	0.9
Cholesterol lowering medication	1.0	1.4	5.3	-0.4	-0.7	-0.9	-2.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	1.2	0.8	-0.9	-0.5	0.8
Pain experienced in last month	0.1	0.2	0.4	0.6	0.5	-0.3	-0.3	0.7
Supplements: Calcium	0.5	0.5	2.2	-0.5	0.1	-0.5	0.2	-1.5
Basal cell carcinoma (self-reported)	1.1	1.3	3.5	1.5	0.4	-0.8	-0.0	1.9
Heart attack/myocardial infarction (self-reported)	1.2	1.5	5.8	0.8	0.5	-2.4	-0.6	0.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.2	1.8	1.5	-0.2	-1.6	0.3
Heart disease (siblings)	0.2	0.2	0.8	-0.5	-0.2	0.9	-0.4	-0.1
Alcohol drinker status: Previous	0.5	0.6	1.6	0.7	0.8	-1.3	-0.1	0.1
Pack years of smoking	0.2	0.2	0.7	-0.5	-0.4	-0.1	0.2	0.8
Impedance of whole body	0.5	2.7	5.4	-2.3	-2.0	0.6	1.3	-1.4
Leg fat mass (left)	0.8	3.3	5.2	2.1	2.1	-0.9	-2.3	-1.2
Arm predicted mass (left)	0.5	2.5	4.5	2.0	2.1	0.3	-2.0	0.1