Hub : Genes

UBQLNL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1750	0.0670	8.9e-03	-0.005	NA	-0.005	NA	-0.005	7.3e-01	NA	9.0e-01	NA	9.0e-01
2	GTEx	Adrenal Gland	0.2488	0.0927	5.0e-03	0.049	NA	0.056	NA	0.049	7.5e-03	NA	4.7e-03	NA	7.5e-03
3	GTEx	Esophagus Muscularis	0.1930	0.0610	7.0e-04	0.078	NA	0.078	NA	0.085	1.8e-05	NA	1.8e-05	NA	7.9e-06
4	GTEx	Lung	0.2860	0.0668	1.4e-05	0.107	NA	0.068	NA	0.075	1.6e-08	NA	6.9e-06	NA	2.2e-06
5	GTEx	Nerve Tibial	0.1508	0.0502	1.8e-03	0.075	NA	0.062	NA	0.091	5.5e-06	NA	3.5e-05	NA	5.3e-07
6	GTEx	Uterus	0.5970	0.1230	2.9e-04	0.066	NA	0.120	NA	0.147	1.9e-02	NA	2.1e-03	NA	6.8e-04
7	METSIM	Adipose	0.1782	0.0377	2.9e-11	0.048	0.085	0.093	0.099	0.082	8.4e-08	1.0e-12	7.9e-14	1.3e-14	2.9e-12
8	ROSMAP	Brain Pre-frontal Cortex	0.0890	0.0290	5.5e-04	-0.002	0.020	0.001	0.019	-0.001	7.5e-01	9.8e-04	1.9e-01	1.3e-03	4.9e-01
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0260	0.0135	5.2e-03	0.015	0.011	-0.001	NA	0.002	6.6e-03	1.6e-02	5.1e-01	NA	1.6e-01
10	TCGA	Brain Lower Grade Glioma	0.0469	0.0272	2.5e-03	-0.002	0.007	0.000	NA	-0.001	9.5e-01	4.7e-02	3.2e-01	NA	4.8e-01
11	TCGA	Thyroid Carcinoma	0.0840	0.0300	1.7e-08	0.070	0.091	0.118	NA	0.119	2.1e-07	3.5e-09	1.4e-11	NA	1.2e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.2	0.9	-1.0	-0.3	0.1	-0.5	-0.1	-0.4	-0.2	0.3	0.2	-0.3	0.3
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	-0.6	0.3	0.4	0.5	0.4	0.5	-0.6	1.0	0.2	-0.3	0.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	-0.5	-0.1	-0.8	-0.2	0.0	-0.8	-0.1	-0.7	-0.7	-1.3	-0.8
Depression (Nagel 2018)	0.5	0.7	2.0	-0.5	-0.7	-1.3	-1.3	-0.9	-0.4	-0.2	-0.2	-0.6	-0.5	-1.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.3	-0.5	1.1	1.0	0.7	0.7	0.7	1.0	-0.1	1.0	1.0	0.5
Neuroticism (Nagel 2018)	0.6	1.5	2.8	-1.1	-1.1	-1.5	-1.2	-1.0	-1.7	-0.7	-0.6	-1.1	-1.2	-1.6
Schizophrenia (2018)	0.2	0.4	1.3	0.0	0.6	0.4	1.1	0.6	0.9	-0.7	1.1	0.0	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.6	0.8	3.4	1.8	0.5	0.6	0.7	0.4	-0.1	1.2	0.5	0.7	-0.1	1.3
Worry (Nagel 2018)	1.6	3.4	7.2	-0.7	-2.0	-2.1	-2.3	-1.8	-2.7	-1.2	-1.0	-1.7	-1.9	-1.9
Alzheimer’s Disease (in mother)	4.5	5.3	11.6	1.5	-1.6	-3.0	-1.9	-2.7	-1.6	-1.8	-2.0	-3.1	-1.9	-3.4
Alzheimer’s Disease (in father)	0.3	0.3	1.3	-0.3	0.3	-0.4	0.1	0.1	0.6	1.1	1.0	0.1	-0.3	-0.2
Alzheimer’s Disease (including proxy)	2.1	3.1	7.5	1.1	-1.0	-2.6	-1.4	-2.2	-0.5	-0.5	-0.9	-2.4	-2.1	-2.7
Crohns Disease (2017)	0.6	1.3	5.0	-2.2	0.1	1.0	-0.1	-0.1	0.4	1.5	0.9	1.4	0.7	1.4
Irritable Bowel Disease (IBD)	0.3	0.7	2.7	-1.2	-0.6	-0.1	-0.9	-0.8	-0.4	0.2	1.6	0.8	0.9	-0.0
Ulcerative Colitis (UC)	0.4	0.7	2.3	-0.3	-0.7	-0.6	-1.0	-0.9	-0.4	-0.7	1.5	0.3	1.0	-0.8
Major Depression (MDD)	0.2	0.3	1.0	-0.1	-0.0	-0.1	-0.4	-0.2	0.6	0.9	0.3	1.0	-0.4	0.8
Reaction Time	0.5	0.9	1.8	-0.9	1.3	0.7	1.3	0.8	1.2	0.7	0.5	0.8	0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.7	-1.5	1.6	1.3	1.6	1.0	0.6	1.6	0.8	1.4	0.9	1.1
Breast Cancer	0.2	0.6	1.5	-0.0	0.9	0.5	0.9	0.8	-0.6	0.6	1.2	0.0	0.1	1.2
Ovarian Cancer	1.0	1.4	2.6	-0.5	-1.4	-1.5	-1.4	-1.6	-1.0	-0.8	-1.3	-1.3	-0.6	-1.1
Prostate Cancer	0.2	0.3	0.7	0.2	-0.5	-0.3	-0.1	-0.6	0.5	-0.5	0.8	-0.6	-0.7	-0.4
Age at First Birth	0.1	0.2	0.8	-0.5	-0.1	0.8	0.0	0.5	-0.1	0.4	0.3	0.1	0.2	0.9
Bipolar Disorder (2011)	0.8	0.8	2.6	-1.6	-0.6	-0.5	-1.3	-0.9	-0.2	-0.5	1.5	-0.1	-0.4	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	-0.6	-1.0	-0.8	-0.5	-0.8	-0.0	-1.2	-0.5	-0.7	-0.4	-1.1
Coronary Artery Disease (CAD)	0.6	0.8	3.1	-1.8	0.1	-0.1	-0.2	-0.6	-0.3	1.4	-0.3	-0.9	-1.4	0.2
Crohns Disease (2012)	0.3	0.4	1.7	-1.3	-0.2	0.2	-0.2	-0.8	-0.1	0.9	0.1	0.1	-0.9	0.8
Mean Putamen Volume	3.8	4.3	8.1	-1.1	2.3	2.0	2.7	2.2	1.9	1.7	2.8	2.1	2.1	1.3
Fasting Glucose	0.6	0.7	3.8	-0.3	0.2	0.2	-0.6	0.1	-0.7	1.4	2.0	-0.4	-0.6	0.4
HbA1C	0.3	0.4	1.5	-1.1	0.2	0.7	0.3	-0.0	1.2	0.1	-0.4	-0.5	0.1	-0.1
HDL Cholesterol	0.3	0.5	1.1	0.6	-0.5	-0.7	-0.4	-0.8	-0.4	0.2	-1.0	-1.0	-0.6	-0.6
LDL Cholesterol	0.4	0.7	3.7	-1.0	-0.7	-0.4	-0.5	-0.2	-1.1	-1.9	-0.6	0.0	-0.0	-0.6
Lupus	0.5	0.7	2.1	0.7	-0.3	-1.3	0.2	-0.8	0.3	-0.9	-0.6	-1.1	-0.8	-1.5
Neuroticism (2016)	0.3	0.5	1.3	-0.5	-0.8	-1.1	-0.7	-0.6	-0.8	0.3	0.4	-0.8	-0.6	-0.7
Primary Biliary Cirrhosis	0.3	0.4	2.7	1.6	-0.2	-0.1	0.3	-0.2	-0.7	-0.0	0.6	0.4	-0.4	0.8
Rheumatoid Arthritis	0.4	0.5	3.3	-0.3	0.3	-0.0	0.7	0.2	-1.8	-0.1	-0.3	0.6	1.0	0.5
Schizophrenia (2014)	0.2	0.4	1.4	0.5	-0.0	0.3	0.5	0.3	0.5	-1.2	0.6	0.1	-0.6	1.0
Triglycerides	0.2	0.3	1.3	0.0	-0.1	0.1	0.2	0.1	1.1	-0.6	1.1	0.5	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	4.2	-1.2	-1.1	-0.5	-0.7	-0.4	0.0	0.1	-0.2	-0.8	-2.0	-0.3
Ulcerative Colitis	0.4	0.6	1.5	0.1	-0.6	-0.8	-0.9	-0.7	-0.9	-1.0	1.2	-0.4	0.3	-0.6
Blood Eosinophil Count	0.3	2.5	5.2	-1.1	-1.1	-1.4	-1.2	-1.8	-2.3	-0.7	-2.0	-1.8	-2.1	-0.7
Blood Platelet Count	1.2	14.0	41.6	-0.6	2.8	4.4	4.5	4.7	3.8	0.3	6.5	3.0	2.5	3.5
Blood Red Count	0.2	2.3	15.0	-0.1	-0.8	-0.9	-1.1	-0.6	-3.9	-0.5	-0.4	-1.6	-2.0	0.3
Blood White Count	0.0	0.3	1.3	0.5	-0.5	-0.1	-0.6	-0.6	-1.1	-0.8	-0.1	-0.1	-0.8	-0.1
Heel T-Score	0.2	1.2	3.6	-1.2	1.2	1.6	0.7	1.2	1.1	0.6	0.4	1.1	0.2	1.9
BMI	0.2	1.2	7.0	-0.4	-0.1	1.1	0.6	0.6	2.6	-1.2	0.2	1.2	0.6	0.6
Height	0.1	1.2	3.8	-0.2	0.4	0.6	1.5	0.7	2.0	-0.0	1.4	1.6	0.9	0.9
Waist Hip Ratio (WHR)	0.2	1.0	2.1	1.2	-1.1	-1.5	-1.4	-1.1	-1.0	0.4	1.1	-0.3	-0.7	-0.6
Systolic Blood Pressure	0.2	1.1	3.3	0.3	0.1	1.7	-0.1	1.3	-0.2	-0.6	-0.9	1.8	0.7	1.6
Smoking Status	0.1	0.2	0.8	-0.5	-0.4	0.1	-0.5	-0.0	0.4	-0.1	0.3	-0.3	0.5	-0.9
Allergy or Eczema	0.1	0.3	0.5	0.6	0.4	0.5	0.2	0.5	0.2	0.7	-0.6	0.6	-0.4	0.7
Cardiovascular Disease	0.4	1.3	2.7	-0.4	0.3	1.3	0.5	1.2	1.3	-0.8	-1.6	1.5	1.1	1.5
Hypothyroidism (self reported)	0.8	1.9	5.1	-0.1	1.6	1.3	1.3	1.1	0.5	2.3	1.3	1.6	1.4	1.6
Respiratory disease	0.2	0.5	1.7	-1.3	-0.4	0.4	-0.7	-0.9	0.1	0.8	-1.0	0.4	-0.7	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	-0.4	0.6	0.6	0.2	0.8	-0.3	1.6	1.1	0.8	-0.4	1.2
Lung FEV1/FVC ratio	0.1	0.6	2.0	-0.7	0.7	0.9	0.8	1.4	-0.4	-0.5	0.1	0.3	1.2	0.5
Lung FVC	0.1	0.8	3.1	0.3	0.3	-1.1	-0.9	-0.3	-1.8	1.0	0.4	-0.9	-0.7	-0.8
Neuroticism	0.2	0.4	1.4	-0.3	-0.4	-1.0	-0.3	-0.5	-1.0	0.5	-0.3	-0.6	-1.2	-0.3
Chronotype (morning person)	0.6	1.5	5.2	-1.8	-0.8	0.7	0.2	0.5	1.8	-0.9	-2.3	1.0	0.9	0.9
Hair Pigment	0.0	0.5	2.0	1.4	0.2	-0.9	0.1	-0.3	-0.2	0.9	0.9	-0.1	-0.6	-0.6
Tanning	0.1	1.4	5.7	-0.1	1.2	0.6	0.4	0.4	1.6	0.6	-1.0	1.9	2.4	-0.4
Hand grip strength (left)	0.2	0.6	1.7	1.2	-0.9	0.2	-0.6	0.2	0.5	-1.1	-1.3	-0.2	0.4	0.6
Number of treatments/medications taken	0.2	0.3	1.0	0.8	0.3	0.8	0.7	1.0	0.6	-0.1	-0.1	-0.1	-0.5	0.1
Average weekly spirits intake	0.5	0.6	1.7	1.3	-0.5	-0.8	0.3	-0.2	0.7	0.3	-0.6	-1.1	-1.3	-0.7
Sensitivity / hurt feelings	0.8	1.4	3.5	-1.7	1.1	0.9	0.8	0.7	1.6	0.2	0.3	1.9	1.2	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	-0.8	0.8	-0.1	0.3	0.4	0.1	1.2	0.4	1.0	1.1	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	2.2	-1.3	-0.3	-0.1	-0.3	-0.3	0.0	-0.4	-1.5	0.3	0.8	-0.4
Relative age of first facial hair	0.4	0.8	2.9	0.3	-0.3	1.3	0.1	0.7	1.2	0.3	1.1	0.6	-0.6	1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	0.8	0.2	0.6	0.6	0.7	-0.7	-0.6	-1.0	0.4	0.0	0.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	4.1	2.0	0.3	0.2	-0.1	-0.1	0.7	0.8	1.3	0.9	0.1	0.5
Ever had hysterectomy (womb removed)	0.9	1.0	6.3	-0.6	0.8	1.1	0.5	0.7	2.5	0.1	0.8	1.1	0.5	0.4
Systolic blood pressure, automated reading	0.8	2.4	6.6	0.0	1.1	2.6	1.2	2.1	0.8	-0.6	1.1	2.5	1.1	1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-1.2	0.8	-0.2	0.5	0.4	-0.5	-0.1	-0.3	0.0	0.7	0.2
Angina	3.0	4.0	7.5	0.4	2.7	2.6	2.6	2.7	1.7	1.8	1.1	1.6	1.6	1.6
Medication for hormone replacement therapy	0.5	0.5	1.3	-0.6	-1.1	-0.7	-0.7	-1.0	-0.9	-0.7	-0.1	-0.7	-0.4	-0.2
Vitamin and mineral supplements	1.6	2.2	4.2	-1.3	1.7	1.7	1.6	1.3	1.9	1.3	1.3	1.1	0.8	2.1
Supplements: Zinc	0.6	0.6	2.2	1.2	0.4	-0.7	0.2	-0.3	-0.7	1.5	0.3	-0.8	-1.0	-0.3
Medication: Co-codamol	0.4	0.4	1.3	0.6	-0.4	0.7	-0.3	0.5	1.0	-0.5	1.2	-0.4	-0.5	0.2
Medication: Metformin	0.5	0.7	3.3	-1.8	0.6	0.6	0.5	0.8	-0.1	0.7	0.7	0.6	-0.4	1.0
Diabetes (father)	2.0	2.5	7.1	-0.1	2.7	1.0	1.9	1.6	0.9	2.5	1.5	0.9	1.3	0.8
Diabetes (mother)	0.2	0.3	1.1	-1.1	-0.5	0.2	0.2	0.3	0.2	-0.6	-0.9	0.1	-0.2	-0.1
Severe depression (siblings)	0.4	0.4	0.8	0.6	0.8	0.8	0.6	0.9	0.8	0.4	-0.3	0.4	0.7	-0.0
Pack years adult smoking proportion	0.1	0.1	0.3	-0.1	-0.1	-0.1	0.4	0.3	-0.0	-0.6	0.6	-0.3	-0.3	0.1
Impedance of leg (right)	0.3	1.6	4.1	-0.5	-0.5	-1.9	-1.3	-1.2	-2.0	0.7	0.4	-1.7	-1.0	-1.4
Leg fat-free mass (left)	0.3	1.6	4.9	-0.6	0.1	1.7	1.0	0.9	2.2	0.2	-0.3	2.1	0.9	1.5
Trunk fat percentage	0.1	0.3	1.0	-0.8	-0.1	0.2	0.1	-0.2	1.0	-0.9	0.2	0.6	-0.4	0.2
Hand grip strength (right)	0.2	0.7	3.4	0.9	-0.3	0.5	-0.3	0.4	0.8	-0.6	-1.8	0.3	0.5	1.2
Townsend deprivation index at recruitment	0.5	0.7	1.5	-1.0	0.9	0.5	1.2	0.8	-0.4	0.1	-0.5	1.0	1.1	0.5
Current tobacco smoking	0.1	0.2	0.8	0.2	0.0	0.4	-0.0	0.4	0.8	0.2	-0.3	0.4	0.9	-0.7
Average weekly fortified wine intake	1.6	1.9	3.3	1.8	-1.7	-1.2	-0.8	-1.3	0.3	-1.7	-0.7	-1.8	-1.1	-1.8
Maternal smoking around birth	1.2	1.7	3.4	0.3	1.8	0.8	1.8	1.4	1.4	0.1	1.2	1.7	1.8	-0.1
Fed-up feelings	0.6	1.0	3.0	0.1	-0.7	-1.3	-0.6	-0.9	-1.4	-0.2	-1.3	-0.6	-1.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	1.0	0.4	0.4	-0.4	-0.5	-0.0	-0.3	1.0	0.2	0.1	-0.3	0.1
Relative age voice broke	0.7	1.0	2.6	0.9	-0.7	0.9	-0.2	0.5	-1.6	1.1	1.2	0.1	-0.9	1.5
Taking other prescription medications	0.1	0.1	0.4	-0.2	-0.3	0.0	-0.1	0.2	-0.1	-0.3	0.3	0.1	-0.3	-0.6
Age when periods started (menarche)	0.2	0.6	3.2	1.8	0.4	-1.0	-0.1	-0.6	-0.3	0.8	-0.1	-0.5	0.1	-0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-0.5	0.3	1.1	0.2	0.8	1.0	0.2	1.3	1.0	1.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.9	-2.0	1.4	1.6	0.8	1.5	0.7	0.7	1.5	1.1	1.6	1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.8	0.2	0.8	0.4	0.3	-0.1	0.1	-0.7	0.5	-0.1	0.6
Qualifications: CSEs or equivalent	0.2	0.3	2.1	-1.5	0.2	-0.2	0.0	-0.3	0.8	-0.2	0.0	-0.0	0.0	-0.4
Serious illness, injury or assault to yourself	0.8	1.0	3.1	-0.9	-1.8	-0.8	-1.3	-1.0	-0.5	-1.4	-0.3	-0.3	-0.7	-0.8
High blood pressure	0.2	0.6	1.5	-0.7	-0.4	1.0	0.1	0.7	1.2	-0.5	-0.8	1.0	0.5	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.9	-0.1	-0.3	0.3	-0.5	0.1	-0.3	-0.1	-1.7	0.4	-0.8	0.6
Multivitamins +/- minerals	1.5	2.0	4.3	0.7	-2.0	-1.6	-2.1	-1.7	-1.2	-1.4	-0.6	-0.7	-0.8	-1.5
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.6	-0.1	0.3	0.6	0.5	-1.0	0.2	0.3	0.2	-0.1	0.7
Supplements: Glucosamine	1.4	1.8	3.2	1.6	1.7	1.7	1.1	1.7	-0.2	1.8	1.5	1.4	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	5.7	-0.6	1.9	1.5	1.5	1.6	0.4	2.1	2.4	1.4	0.8	1.4
Medication: Atenolol	0.9	1.2	2.3	-0.8	1.4	1.5	1.3	1.2	1.2	0.4	0.7	0.9	1.2	0.6
Medication: Levothyroxine sodium	0.5	0.9	2.4	-0.0	0.7	1.0	0.5	0.9	0.1	0.9	1.6	1.1	0.1	1.5
Sitting height	0.1	0.9	3.2	-1.3	-0.0	0.9	0.3	0.5	1.8	0.6	0.6	0.5	-0.3	1.7
Chronic bronchitis/emphysema (father)	0.4	0.4	1.7	1.3	-0.1	0.6	0.3	0.5	0.6	-0.2	1.1	0.5	0.6	-0.0
High blood pressure (mother)	0.1	0.2	0.5	-0.2	-0.3	-0.2	-0.2	-0.4	-0.6	0.7	-0.4	0.2	0.7	0.1
Body mass index (BMI)	0.1	0.6	2.2	-0.0	-0.3	0.9	0.4	0.4	1.5	-1.1	-0.2	1.1	0.1	0.7
Impedance of leg (left)	0.4	2.0	4.9	-0.1	-0.5	-2.1	-1.3	-1.3	-2.2	0.4	0.4	-2.2	-1.3	-1.5
Leg predicted mass (left)	0.3	1.6	4.9	-0.6	0.1	1.7	1.0	0.9	2.2	0.2	-0.2	2.1	0.8	1.5
Trunk fat mass	0.1	0.6	2.5	-0.8	-0.0	0.7	0.4	0.2	1.6	-0.5	0.4	1.2	-0.1	0.7
Waist circumference	0.2	0.8	3.9	0.4	-0.4	0.9	0.2	0.4	2.0	-0.7	0.5	1.4	0.4	0.6
Number of incorrect matches in round	0.3	0.5	1.4	0.2	1.2	0.7	1.1	0.5	0.4	0.5	0.8	0.4	1.1	0.3
Past tobacco smoking	0.2	0.4	2.0	-0.6	-0.0	-0.4	0.1	-0.4	-0.0	-1.4	-1.4	-0.0	0.0	0.1
Alcohol usually taken with meals	0.3	0.4	1.5	-1.2	-0.3	0.8	-0.0	0.6	0.4	-0.3	0.0	0.5	0.8	1.0
Nervous feelings	0.7	1.3	3.7	0.1	-0.9	-1.2	-1.4	-1.2	-1.9	-0.3	-0.4	-1.0	-1.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.1	-1.0	-0.8	-1.1	-1.2	-0.7	-0.2	-0.8	-0.3	-0.4	-0.4	-1.4
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-1.0	0.0	0.3	0.5	0.3	-0.3	-0.8	-1.1	0.1	0.0	-0.2
Hair/balding pattern: Pattern 2	0.9	1.2	2.6	1.5	0.5	0.9	0.8	1.0	0.7	0.6	1.0	1.5	0.9	1.6
Had menopause	0.4	0.5	1.7	-1.3	-0.9	-0.2	-0.9	-0.7	0.9	-1.0	-0.3	0.1	-0.2	-0.5
Had other major operations	0.6	0.8	1.5	-0.9	1.1	1.0	1.2	1.2	-0.2	1.1	-0.5	-0.2	-0.2	1.0
Forced vital capacity (FVC)	0.1	0.2	0.7	-0.1	-0.6	-0.8	-0.7	-0.2	-0.1	-0.3	0.6	-0.1	-0.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.7	-1.4	1.4	1.4	0.7	1.2	0.3	1.2	2.6	1.1	0.9	1.2
Ever unenthusiastic/disinterested for a whole week	4.1	5.0	7.7	0.1	-2.0	-2.6	-2.2	-2.2	-1.8	-2.2	-2.7	-2.3	-2.8	-2.4
Qualifications: None of the above	0.5	1.0	8.0	2.8	0.1	0.5	-0.2	0.2	0.2	1.0	1.1	0.6	-0.5	0.3
Financial difficulties in last 2 years	2.3	3.0	4.9	0.1	-2.0	-2.1	-2.2	-1.8	-2.0	-1.0	-1.1	-2.1	-1.4	-2.1
Mouth/teeth dental problems	0.2	0.3	0.7	0.2	0.6	0.8	0.7	0.7	-0.3	0.7	-0.9	0.5	0.2	0.4
Heart attack	0.2	0.3	0.8	0.8	0.3	0.5	0.3	0.0	-0.2	0.7	0.9	0.3	-0.2	0.6
Allergy	0.2	0.5	2.9	-0.2	0.9	0.1	0.9	0.5	0.1	-0.0	1.7	-0.2	1.0	-0.2
Pain all over the body in last month	0.3	0.3	1.0	-0.9	0.4	-0.3	0.2	0.2	0.5	-0.5	0.2	0.2	0.6	-1.0
Diabetes (self-reported)	1.4	2.2	5.3	-2.3	1.4	1.6	1.1	1.8	0.3	1.2	1.3	1.4	0.4	2.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.9	0.1	-0.6	0.0	-0.5	-0.5	-0.5	-0.5	-1.0	0.4	0.5	0.1
Medication: Ramipril	0.6	0.8	2.1	-0.6	-0.3	1.0	-0.1	0.5	1.2	-0.0	-1.2	1.3	0.8	1.5
Medication: Simvastatin	0.8	1.2	2.7	0.2	1.1	1.6	1.4	1.5	1.1	-0.1	1.2	1.2	0.3	0.8
Fluid intelligence score	1.4	2.9	4.6	-1.0	1.8	1.8	2.1	1.6	2.1	1.6	0.9	1.5	1.9	1.7
Illnesses of siblings	0.2	0.3	1.8	1.3	0.3	-0.3	0.1	-0.3	0.7	0.1	-0.6	-0.2	0.1	-0.4
Neuroticism score	0.3	0.7	1.4	-1.0	-0.7	-1.2	-0.9	-1.0	-0.9	0.5	-0.7	-0.2	-0.9	-0.6
Weight	0.2	1.1	4.3	-0.4	-0.1	1.3	0.8	0.8	2.1	-0.4	0.3	1.6	0.3	1.2
Impedance of arm (right)	0.1	0.6	1.6	-0.7	0.5	-1.1	0.2	-0.8	-1.0	0.2	-0.3	-1.2	-0.7	-0.7
Arm fat percentage (right)	0.1	0.3	0.8	-0.9	-0.1	0.6	0.4	0.1	0.8	-0.9	0.2	0.7	-0.5	0.5
Trunk fat-free mass	0.2	1.2	3.0	-0.6	-0.2	1.6	0.7	1.0	1.6	0.4	0.0	1.7	0.5	1.5
Hip circumference	0.2	1.0	4.9	-0.0	-0.2	1.4	0.7	0.7	2.2	-0.8	-0.5	1.1	0.4	0.9
Time employed in main current job	0.1	0.2	0.5	-0.4	0.7	0.2	0.2	0.3	0.5	0.6	-0.3	0.3	-0.2	0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-1.1	1.1	0.5	0.6	0.8	0.3	0.9	1.1	0.6	0.8	0.6
Father’s age at death	1.1	1.5	5.8	-0.2	-1.8	-1.1	-1.5	-0.8	-0.5	-2.4	-0.1	-1.0	-0.9	-1.2
Worrier / anxious feelings	0.8	1.6	2.9	-1.6	-1.6	-1.2	-1.5	-1.2	-1.7	-1.0	-1.3	-0.7	-0.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.2	-0.0	-1.3	-0.7	-1.5	-0.9	0.1	-0.0	0.5	-0.2	-0.5	-0.6
Falls in the last year	0.3	0.4	2.5	-0.4	-0.2	0.8	-0.2	0.4	0.5	0.1	1.6	0.7	-0.1	0.0
Hair/balding pattern: Pattern 3	0.9	1.3	6.7	-1.3	1.2	0.0	0.6	0.3	-1.1	2.6	1.4	-0.3	-0.7	0.6
Number of live births	1.0	1.4	5.0	1.0	1.0	1.3	1.2	1.2	2.2	0.6	1.4	0.7	0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.5	0.2	-0.4	-0.5	-0.4	0.2	-0.0	-0.7	0.2	-0.0	0.6	-0.5
Pulse rate	0.3	0.4	1.1	1.0	-0.2	0.7	0.2	0.6	0.7	-0.7	-1.0	0.0	-0.4	0.6
Happiness	0.4	0.4	3.0	0.2	0.4	-0.2	0.2	-0.1	-1.7	0.6	-0.8	-0.1	-0.6	-0.2
Noisy workplace	0.3	0.3	0.8	-0.7	0.3	0.3	0.9	0.7	-0.7	-0.9	-0.6	-0.4	-0.4	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.0	-2.2	-1.0	-0.9	-0.8	-0.6	-0.4	-0.6	-1.5	-0.7	-0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.0	-0.2	0.4	0.2	0.2	-0.0	-0.4	-0.5	-0.3	-0.6	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	2.2	-0.1	-0.7	-0.2	-0.2	-0.2	0.0	-1.5	0.9	-0.1	0.2	-0.5
Asthma	0.4	0.7	2.0	-1.0	-0.8	0.1	-1.2	-1.1	0.2	1.4	-0.9	0.3	-0.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	4.0	2.0	0.0	0.1	0.5	0.3	0.6	-0.1	0.2	-0.1	-0.3	0.1
Medication: Cholesterol lowering	0.6	0.9	2.5	0.2	0.9	1.5	1.3	1.6	1.0	-0.0	0.4	0.6	-0.1	1.3
Depression (self-reported)	0.1	0.2	0.5	-0.5	0.5	0.1	0.7	0.6	0.1	-0.1	0.3	0.5	0.2	0.1
Medication: Lansoprazole	0.4	0.4	1.1	1.0	0.7	0.6	0.7	0.8	0.7	0.3	0.7	0.4	-0.0	0.5
Prospective memory result	0.3	0.3	1.7	0.5	0.0	-0.5	-0.5	0.1	-0.7	0.2	1.3	-0.3	-0.1	-0.9
Lung cancer (father)	0.3	0.3	1.2	0.0	0.1	0.1	0.1	-0.3	0.7	1.1	0.6	0.6	1.1	0.0
Illnesses of mother	0.7	0.9	4.0	-0.7	0.5	0.8	1.0	1.2	0.5	-0.2	2.0	0.8	0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.9	0.1	0.6	0.1	0.0	0.7	-0.0	0.3	1.0	0.2	0.6	-0.0
Pulse wave Arterial Stiffness index	2.9	3.3	6.0	1.1	2.2	2.0	1.8	1.8	2.2	1.7	0.5	2.2	2.4	1.2
Impedance of arm (left)	0.3	1.3	3.1	-0.5	-0.3	-1.8	-0.7	-1.4	-1.5	-0.1	-0.6	-1.7	-1.0	-1.3
Arm fat mass (right)	0.1	0.5	1.3	-0.4	-0.2	0.9	0.5	0.5	1.2	-0.8	0.5	1.1	-0.1	0.8
Trunk predicted mass	0.2	1.1	2.9	-0.6	-0.2	1.5	0.6	1.0	1.6	0.5	0.1	1.7	0.5	1.5
Standing height	0.1	0.8	1.9	-1.0	0.3	0.8	0.8	0.7	1.4	1.2	0.8	1.0	0.2	1.2
Length of working week for main job	0.6	0.6	4.7	-2.2	0.6	0.4	0.3	0.3	0.3	0.7	0.6	-0.0	0.8	-0.0
Exposure to tobacco smoke at home	0.7	0.8	2.1	0.4	0.5	1.3	1.1	1.1	1.5	-0.1	-0.1	0.9	0.4	0.9
Breastfed as a baby	1.0	1.2	3.2	-0.0	0.9	1.4	0.7	0.9	1.4	1.3	-0.2	1.8	-0.4	1.6
Tense / ‘highly strung’	0.2	0.4	1.4	-0.1	0.0	-0.6	-0.6	-0.3	0.0	-0.7	-0.9	0.1	0.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.5	-0.6	-0.2	-0.5	0.1	-1.2	-0.5	0.4	-0.2	-0.6	0.1
Hair/balding pattern: Pattern 4	0.2	0.4	3.4	-0.4	-0.0	0.5	-0.1	0.3	-0.1	-1.8	0.3	0.2	0.5	0.3
Birth weight of first child	1.6	2.9	4.5	-0.0	-2.1	-2.1	-1.7	-1.6	-2.1	-1.2	-1.5	-1.7	-1.8	-1.7
Peak expiratory flow (PEF)	0.4	0.8	2.2	0.7	-1.4	-0.7	-1.0	-0.4	-1.5	-0.9	-0.3	-0.9	-0.2	-1.1
Pulse wave reflection index	0.3	0.3	0.9	0.7	0.2	-0.4	0.2	-0.4	-0.5	0.9	0.2	-0.1	0.7	-0.9
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.7	-0.2	1.6	1.6	1.4	1.6	1.6	1.4	0.8	1.3	1.4	1.0
Loud music exposure frequency	0.8	0.9	2.3	-1.2	0.3	1.0	0.5	0.9	0.4	-0.0	0.3	1.5	1.2	1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.4	-0.8	1.1	0.5	1.0	1.0	0.1	0.7	0.4	1.0	1.8	0.3
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.0	-1.0	1.2	0.7	0.6	0.5	1.3	1.1	0.8	0.9	0.8	1.4
Blood clot in the leg (DVT)	2.4	3.1	11.3	0.3	1.7	2.2	1.9	1.8	3.4	0.7	1.1	1.9	1.2	1.2
Medication: Paracetamol	0.9	1.5	2.8	1.4	-1.3	-1.3	-1.3	-1.0	-0.6	-1.5	-0.8	-1.2	-0.8	-1.7
Headache pain in last month	0.8	1.4	4.3	0.2	0.8	1.1	0.9	1.3	0.9	0.1	0.6	1.9	2.1	1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	0.1	-0.3	-1.5	-0.5	-1.3	-1.1	-0.6	-0.6	-0.5	0.1	-1.4
Glaucoma (self-reported)	0.2	0.2	0.7	0.7	0.9	-0.1	0.5	0.5	-0.3	0.5	0.1	-0.4	-0.1	-0.4
Gout (self-reported)	0.6	0.9	1.8	0.5	0.8	1.0	1.2	1.2	1.4	0.5	0.1	1.2	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.5	0.6	1.0	0.9	0.8	1.0	0.1	1.6	1.9	1.3	0.9	1.2
Medication: Amlodipine	0.3	0.4	2.5	0.1	-0.5	0.2	0.1	-0.4	0.1	-0.9	-0.4	-0.1	-1.6	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	-0.5	-0.9	-0.7	-1.2	-1.0	-0.2	0.5	-1.3	-0.8	-0.4	-0.3
Birth weight	0.1	0.3	1.8	-0.3	-0.5	-0.4	-0.5	-0.4	0.2	-0.6	-1.3	-0.0	0.3	0.1
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.5	0.8	-1.4	-1.7	-1.4	-1.4	-0.1	-1.5	-1.7	-1.2	-0.6	-2.1
High blood pressure (siblings)	0.3	0.4	1.7	-0.9	-1.0	0.3	-0.2	0.1	-1.3	-0.4	-0.6	-0.3	-0.5	0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	2.5	-0.1	0.5	0.2	0.1	0.8	0.5	0.7	1.6	0.6	0.5	0.3
Body fat percentage	0.0	0.2	0.7	-0.6	-0.2	0.2	-0.0	-0.2	0.6	-0.8	0.3	0.5	-0.5	0.2
Leg fat percentage (right)	0.0	0.1	0.4	-0.6	-0.4	0.2	-0.4	-0.2	0.3	-0.2	-0.1	0.4	-0.5	0.1
Arm fat-free mass (right)	0.2	0.8	2.7	-0.3	-0.4	1.2	0.3	0.7	1.6	0.2	0.2	1.6	0.3	1.2
Exposure to tobacco smoke outside home	1.0	1.3	3.8	-2.0	-1.2	-1.1	-1.0	-1.2	-1.5	0.6	0.2	-0.3	-0.3	-1.8
Comparative body size at age 10	0.8	2.2	6.5	0.5	2.5	1.4	2.3	2.2	0.7	1.1	-0.5	0.8	0.4	1.5
Number of full brothers	0.2	0.2	0.5	0.3	-0.5	-0.5	-0.2	-0.7	-0.0	-0.0	0.4	0.7	0.6	-0.0
Worry too long after embarrassment	0.1	0.2	1.7	-0.4	-0.2	-0.4	0.1	-0.4	0.3	0.3	-1.3	0.2	0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.3	0.5	0.6	0.3	0.4	0.6	-0.4	0.6	1.1	0.5	0.6	0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-0.7	-1.1	-0.3	-1.1	-0.6	-1.0	-0.2	-0.5	0.7	-0.5	0.1
Number of children fathered	0.9	1.1	2.3	1.5	-1.1	-1.1	-1.3	-1.2	-0.3	0.0	-0.4	-0.9	-1.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	3.0	-0.2	0.3	0.7	0.4	0.2	1.7	0.1	0.9	0.6	0.8	0.1
Age at first live birth	0.4	0.7	1.7	-0.4	-1.3	-0.4	-1.0	-1.0	-0.9	0.0	-1.2	-0.7	-0.6	-0.4
Pulse wave peak to peak time	2.3	2.7	4.9	-1.2	-1.9	-1.8	-1.6	-1.6	-1.8	-1.5	-0.3	-2.0	-2.2	-1.2
Health satisfaction	0.3	0.4	1.1	1.0	-0.2	0.1	-0.7	0.0	-0.6	0.1	-1.0	0.4	-0.6	1.0
Shortness of breath walking on level ground	1.4	1.7	4.0	-0.5	-2.0	-1.4	-1.7	-1.3	-0.3	-1.5	-1.3	-0.9	-0.6	-1.6
Qualifications: College or University degree	0.3	1.0	2.8	-1.0	-0.5	-1.0	-0.8	-0.7	-1.5	0.7	-1.7	-1.5	-0.3	-0.3
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.3	-0.6	0.6	-0.1	0.1	0.4	-0.6	0.0	0.6	0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.6	-1.5	-0.5	0.0	-0.3	0.1	0.4	-0.1	1.6	0.3	-0.1	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.2	-0.2	-0.3	-0.2	-0.3	0.1	-0.1	-0.6	-0.2	-0.4	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	2.2	-1.5	0.2	-0.3	0.3	-0.7	-0.0	0.3	-0.7	0.0	-0.0	0.1
Neck or shoulder pain in last month	0.2	0.2	1.2	0.5	0.4	0.1	-0.1	0.2	-0.2	1.1	0.8	0.1	-0.0	-0.3
Medication: Blood pressure	0.3	0.5	1.3	1.1	-0.3	1.1	0.0	0.8	0.7	0.5	-0.3	0.0	-0.8	1.0
Angina (self-reported)	3.2	4.3	8.2	0.4	2.8	2.8	2.8	2.9	1.9	1.6	1.2	1.6	1.6	1.7
Migraine (self-reported)	0.3	0.3	1.0	0.1	0.6	0.2	0.9	0.6	1.0	0.8	0.2	0.4	0.7	-0.1
Medication: Ibuprofen	0.2	0.2	1.1	1.1	-0.2	-0.2	0.2	-0.0	0.7	-0.3	-0.5	-0.5	-0.6	-0.1
Medication: Allopurinol	0.4	0.5	2.8	0.3	0.5	0.7	0.9	0.4	1.7	0.2	-0.2	0.9	0.5	0.3
Medication: Omeprazole	0.3	0.4	1.6	0.7	0.3	0.7	0.5	0.4	0.5	-0.1	1.3	0.6	0.7	0.3
Medication: Seretide 50 evohaler	0.6	0.7	2.5	-1.6	-1.1	-0.7	-0.8	-0.8	-0.2	-0.0	0.5	-0.9	-1.2	-0.2
Mean time to correctly identify matches	0.4	0.7	1.8	-0.6	1.2	0.8	1.3	0.6	1.0	0.6	1.2	0.4	0.3	0.8
Heart disease (mother)	2.3	2.8	5.3	0.6	-1.9	-1.7	-2.1	-1.8	-1.5	-1.5	-1.8	-1.8	-0.4	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.6	0.7	0.8	-0.0	0.7	0.3	-0.3	1.3	0.3	0.4	0.1	0.1
Whole body fat mass	0.2	0.7	2.4	-0.8	0.0	0.9	0.6	0.4	1.6	-0.6	0.5	1.3	0.2	0.8
Leg fat mass (right)	0.1	0.5	2.0	-0.7	-0.1	0.9	0.4	0.4	1.4	-0.2	0.6	1.3	0.4	0.5
Arm predicted mass (right)	0.2	0.8	2.6	-0.0	-0.4	1.2	0.3	0.7	1.5	0.1	0.2	1.6	0.2	1.2
Pulse rate, automated reading	0.2	0.8	2.2	1.3	-0.1	0.7	0.9	0.7	1.3	-1.5	-0.3	0.9	0.4	0.3
Alcohol intake frequency.	0.3	0.6	3.5	1.9	0.6	-0.0	0.2	0.3	0.2	0.1	1.0	0.3	0.9	-0.8
Comparative height size at age 10	1.0	5.3	10.4	-1.2	2.0	2.8	2.4	2.4	3.2	1.6	1.3	2.9	1.6	3.0
Number of full sisters	1.2	1.4	3.0	0.4	-1.3	-1.6	-1.3	-1.6	-0.6	0.8	-0.5	-1.5	-0.9	-1.7
Suffer from ‘nerves’	2.0	3.2	5.4	-0.7	-2.0	-2.3	-2.2	-1.8	-2.1	-1.8	0.6	-2.0	-1.7	-1.7
Overall health rating	0.3	0.6	2.4	0.1	-0.8	-0.2	-0.6	-0.3	-0.2	-1.5	-0.9	0.4	1.0	-1.0
Chest pain or discomfort	0.4	0.5	3.7	0.3	-0.8	0.5	-0.6	0.0	-0.7	0.1	-1.9	0.0	-0.4	0.3
Had major operations	1.7	1.9	3.1	1.0	1.7	1.5	1.6	1.4	0.7	1.3	1.8	1.7	1.2	1.1
Age at last live birth	0.4	0.6	1.5	0.4	-0.8	-0.5	-0.5	-1.0	0.2	-0.1	-0.8	-1.0	-0.9	-1.2
Family relationship satisfaction	1.7	2.1	4.7	-0.6	1.6	1.4	1.9	1.6	1.8	0.1	0.2	2.0	2.2	0.7
Leg pain on walking	0.6	0.8	1.8	-0.3	0.6	1.3	0.5	1.2	0.7	0.6	0.2	1.0	1.1	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.3	-0.7	-0.9	-1.4	-1.5	-1.3	-1.4	-0.1	-0.9	-1.1	-1.1	-1.2
Commuting to job workplace: Car/motor vehicle	1.7	2.0	6.7	2.6	0.1	1.2	0.1	1.2	0.8	1.0	1.8	1.9	1.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.1	0.6	0.9	0.9	0.7	0.8	-0.0	1.8	0.9	0.7	0.1	1.3
Medication: Aspirin	0.8	1.1	2.4	0.1	0.9	1.5	0.6	1.4	0.1	1.2	1.5	0.8	0.6	1.1
Supplements: Vitamin C	1.2	1.4	5.9	2.4	-0.3	-1.0	0.1	-0.5	-1.0	-0.0	-0.5	-1.9	-1.0	-1.5
Knee pain experienced in last month	0.6	1.0	2.6	0.1	-1.6	-0.8	-1.0	-1.0	-1.0	-1.1	0.1	-1.2	-0.4	-1.3
Hypertension (Self-reported)	0.2	0.7	1.9	-1.4	-0.6	0.7	-0.3	0.4	1.2	-0.6	-1.3	0.7	0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	0.3	0.4	0.2	0.7	0.5	0.9	0.0	0.5	-0.0	-0.5	0.3
Illnesses of father: Heart disease	0.7	1.0	2.4	-1.5	-0.4	-0.8	-0.3	-0.8	-1.1	0.4	-1.2	-1.4	-1.3	-0.5
Illnesses of siblings: Diabetes	2.3	2.8	7.0	0.9	1.5	1.4	1.4	1.4	2.4	0.3	1.3	2.6	2.5	1.2
Smoking status: Previous	0.3	0.4	1.7	0.3	-0.3	0.3	-0.4	0.3	-0.6	1.1	1.3	-0.3	-0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	0.2	0.8	1.1	0.9	1.0	0.6	1.5	0.7	1.4	1.3	1.3
Whole body fat-free mass	0.2	1.4	4.0	-0.6	-0.1	1.6	0.9	1.0	2.0	0.2	-0.1	1.9	0.7	1.5
Leg fat-free mass (right)	0.3	1.5	5.1	-0.5	0.2	1.6	1.1	0.9	2.3	0.1	-0.3	1.9	0.8	1.5
Arm fat percentage (left)	0.1	0.3	0.6	-0.8	-0.3	0.4	0.1	-0.1	0.7	-0.8	0.0	0.7	-0.5	0.4
Average weekly red wine intake	0.3	0.4	0.9	-0.8	-0.7	0.7	-0.7	0.1	0.9	-0.6	-0.7	0.2	-0.0	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.1	0.3	0.7	0.5	0.5	0.6	0.2	0.6	0.2	0.2	0.6
Mood swings	0.2	0.4	1.7	-0.2	0.8	-0.2	0.8	0.7	-0.2	1.3	0.3	0.1	-0.4	0.3
Loneliness, isolation	0.2	0.3	1.0	-0.2	0.4	-0.9	-0.0	-0.5	-0.0	0.8	-0.3	-0.6	-1.0	-0.5
Long-standing illness, disability or infirmity	1.0	1.6	4.7	-0.3	-1.1	-1.2	-1.2	-1.1	-0.4	-1.4	-2.2	-0.8	-1.1	-1.9
Ever had bowel cancer screening	0.7	0.9	1.5	-0.9	-1.1	-0.6	-1.2	-0.9	-1.1	-1.0	0.3	-0.9	-1.2	-0.2
Diabetes diagnosed by doctor	1.0	1.6	3.4	-1.8	1.4	1.1	1.0	1.6	0.1	1.2	1.4	1.1	0.3	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.6	-1.6	-0.5	-1.3	-0.3	-1.0	1.3	-0.7	-0.9	-0.9	-0.9	-1.2
Friendships satisfaction	0.9	1.1	2.6	-0.1	1.4	1.0	1.6	1.2	1.2	0.4	-1.0	1.1	0.7	1.0
Qualifications: nursing, teaching	0.4	0.6	1.1	0.5	0.5	0.8	1.0	0.6	-0.4	0.9	-0.6	1.0	0.6	1.0
Commuting to job workplace: Walk	0.9	0.9	2.0	-0.1	-0.9	-1.4	-0.8	-1.2	-1.2	-0.4	-0.8	-1.2	-0.7	-1.1
Eye problems/disorders: Cataract	0.7	0.9	3.0	-0.6	-0.6	-1.0	-0.5	-1.3	-0.7	-0.3	-1.7	-1.0	-1.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.4	-0.4	-1.5	-1.6	-1.0	-1.2	0.0	-0.8	-0.7	-1.3	-1.5	-1.2
Medication for cholesterol	0.2	0.3	2.0	0.1	0.8	0.1	0.2	0.5	-0.5	1.4	0.3	-0.1	0.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.8	1.3	-0.1	0.7	-0.6	-0.1	1.3	1.0	0.8	0.7	-1.3	1.2
Back pain experienced in last month	0.5	0.7	2.1	0.6	0.5	1.1	0.5	1.4	0.4	0.7	-0.4	0.7	1.3	0.8
Mineral and other dietary supplements	0.5	0.7	4.3	-2.1	-0.4	-0.4	-0.4	-0.6	0.3	-0.9	-1.0	-0.3	0.3	0.4
Breast cancer (self-reported)	1.6	1.9	4.3	-0.5	-1.2	-1.0	-0.7	-0.7	-1.3	-2.0	-2.1	-1.6	-1.1	-1.6
Asthma (self-reported)	0.4	0.7	1.9	-1.1	-0.9	0.4	-1.1	-0.9	0.2	1.4	-0.8	0.3	-1.0	0.5
Osteoporosis (self-reported)	0.7	0.8	3.8	-0.2	0.2	0.5	0.3	0.1	-0.5	0.3	-2.0	0.0	-1.5	1.6
Osteoarthritis (self-reported)	0.3	0.5	1.3	0.9	-0.3	1.1	0.6	0.9	0.9	-0.3	0.0	0.6	0.4	0.4
Medication: Aspirin	0.4	0.5	1.5	0.4	0.7	1.2	0.4	1.2	-0.2	0.8	0.7	0.3	-0.0	0.8
Medication: Gliclazide	0.8	0.9	1.9	-1.1	1.4	0.5	1.3	1.4	-0.9	0.5	0.1	-0.1	-0.8	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.6	1.2	0.5	1.1	0.9	0.9	1.0	0.2	-1.1	1.2	1.2	1.1
Smoking status: Current	0.2	0.3	1.2	0.1	0.2	0.3	-0.1	0.3	1.0	0.2	-0.3	0.4	1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.3	1.1	0.2	0.1	0.1	0.4	-0.7	-0.2	1.5	-0.4	0.7	-0.8
Whole body water mass	0.3	1.5	4.1	-0.5	-0.0	1.8	0.9	1.1	1.9	0.2	-0.0	2.0	0.7	1.7
Leg predicted mass (right)	0.3	1.5	5.0	-0.5	0.2	1.6	1.1	0.9	2.2	0.1	-0.2	2.0	0.8	1.5
Arm fat mass (left)	0.2	0.7	2.0	-0.6	-0.4	1.0	0.4	0.4	1.4	-0.8	0.3	1.3	-0.1	0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.8	-0.2	0.3	0.4	0.3	-0.6	-0.5	-0.0	-0.4	-0.3	-0.2
Average weekly champagne plus white wine intake	1.2	1.6	5.3	-0.5	-1.8	-0.9	-1.3	-1.2	-1.0	-0.6	-2.3	-1.3	-1.3	-0.1
Miserableness	0.8	1.4	3.2	-0.6	-1.4	-1.6	-1.2	-1.0	-1.8	-1.1	-1.3	-0.7	-0.3	-1.3
Guilty feelings	0.2	0.3	0.8	-0.8	-0.3	-0.6	-0.1	-0.6	-0.9	0.0	0.6	-0.3	-0.7	-0.4
Wears glasses or contact lenses	2.7	3.1	6.5	-0.3	1.8	1.9	1.7	1.8	2.3	1.4	2.6	2.0	0.8	1.5
Ever taken oral contraceptive pill	1.0	1.2	3.5	-0.1	-0.6	-1.0	-0.8	-0.9	-1.2	0.6	-1.1	-1.9	-1.8	-0.4
Hearing aid user	0.3	0.3	1.5	-0.1	-0.1	-0.5	-0.6	-0.0	-0.3	-1.2	-0.5	0.1	0.2	-1.1
Mother’s age at death	0.4	0.5	2.1	0.3	-0.2	-0.4	-0.7	-0.2	-1.1	0.1	0.1	-1.4	-1.3	-0.4
Financial situation satisfaction	0.8	1.0	2.8	-1.7	1.2	1.0	1.0	1.1	0.3	0.3	-0.5	1.0	1.4	-0.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.8	1.2	-1.2	-1.5	-1.3	-1.1	-0.9	-1.9	0.1	-1.2	0.4	-2.2
Commuting to job workplace: Public transport	0.5	0.6	2.8	-1.7	-0.0	-0.3	-0.1	-0.6	-0.6	-0.2	-1.5	0.2	0.2	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	0.9	1.1	0.2	0.8	0.7	1.1	1.4	0.5	0.1	0.2	-0.3
Medication: Blood pressure	0.2	0.4	1.6	-1.3	-0.4	0.1	-0.1	-0.2	0.7	-1.0	-1.0	0.0	-0.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	0.5	-1.0	-0.0	-0.7	-0.1	-1.2	0.3	-0.1	-0.8	-0.8	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.5	1.6	0.3	0.9	0.4	0.9	-0.2	0.3	0.7	0.7	-0.1	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.1	0.9	-0.6	-0.2	0.1	-0.1	-0.5	-1.1	0.8	-0.2	-0.8	-0.8
Medication: Bendroflumethiazide	0.5	0.7	3.2	0.1	-0.7	-0.4	-0.6	-0.8	0.8	-0.6	-1.8	-0.5	-0.6	-1.1
Medication: Paracetamol	0.3	0.5	1.6	1.1	-0.4	-0.7	0.1	-0.2	-0.4	-1.3	-0.3	-0.9	-0.6	-0.5
Medication: Lisinopril	0.3	0.3	2.0	1.4	-0.2	0.5	0.3	0.7	-0.4	-0.4	0.1	-0.5	-0.5	-0.4
Medication: Atorvastatin	0.2	0.3	1.4	1.2	-0.2	-0.4	-0.3	-0.1	-0.5	0.5	-0.2	-0.3	-0.9	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.3	-0.1	-0.4	-0.0	-0.3	0.2	0.4	-0.4	0.2	-0.1	-0.5
Alcohol drinker status: Never	0.2	0.2	1.1	0.8	-0.2	0.3	0.0	-0.0	0.3	-0.0	1.0	0.3	0.7	0.1
Ever smoked	0.5	0.9	3.2	1.1	0.7	0.5	0.6	0.8	0.9	1.8	1.6	0.3	0.3	0.2
Basal metabolic rate	0.2	1.3	3.8	-0.5	-0.1	1.6	0.9	1.0	1.9	0.1	-0.1	1.9	0.7	1.4
Leg fat percentage (left)	0.0	0.1	0.5	-0.4	-0.4	-0.0	-0.4	-0.3	0.2	-0.4	0.1	0.2	-0.7	0.1
Arm fat-free mass (left)	0.2	1.1	3.0	-0.5	-0.0	1.5	0.7	1.1	1.7	-0.1	0.6	1.6	0.4	1.4
Number of operations (self-reported)	0.4	0.6	3.9	-0.1	0.9	-0.0	0.4	0.1	-0.1	2.0	1.2	-0.0	0.1	-0.1
Average weekly beer plus cider intake	0.1	0.2	0.7	0.8	-0.0	-0.0	-0.5	-0.5	-0.7	0.4	-0.2	0.5	-0.1	-0.5
Irritability	0.3	0.6	3.2	-0.9	0.3	-0.4	-0.3	-0.3	-0.2	1.8	0.8	0.1	0.9	-0.6
Risk taking	0.3	0.4	1.1	0.0	-0.2	-0.4	-0.9	-0.4	0.1	-0.1	-1.0	-0.9	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.4	-0.3	-2.2	-0.9	-2.3	-1.7	0.3	-1.6	-1.3	-1.3	-1.8	-0.3
Fractured/broken bones in last 5 years	0.5	0.6	2.4	-0.7	-0.4	-0.8	-0.4	-0.8	0.0	-1.6	-0.4	-0.3	-0.9	-1.1
Age started oral contraceptive pill	0.2	0.3	1.7	-0.1	0.2	0.1	0.2	0.2	-0.5	0.5	1.3	-0.6	-0.6	-0.3
Diastolic blood pressure, automated reading	0.6	1.8	4.1	-0.8	0.9	2.0	1.1	2.0	0.9	-1.1	0.0	1.9	1.1	1.5
Ever depressed for a whole week	0.8	1.0	3.0	-0.6	-1.0	-0.8	-0.9	-0.8	0.2	-1.7	-1.5	-0.1	0.0	-1.3
Unable to work because of sickness or disability	1.0	1.3	4.7	-0.2	0.8	1.0	0.9	0.5	2.2	1.3	1.1	1.5	1.2	0.5
Commuting to job workplace: Cycle	0.6	0.8	1.9	-0.3	-0.4	-0.9	-0.3	-1.1	0.7	-0.8	-0.6	-1.4	-1.0	-1.3
Myopia	0.1	0.1	0.3	0.2	0.4	-0.4	0.2	-0.4	-0.0	0.5	0.4	0.4	0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	0.6	-0.1	-1.1	-0.6	-1.1	-1.0	-0.2	0.0	-1.0	-0.3	-0.8
Cholesterol lowering medication	0.3	0.4	1.2	1.1	-0.0	-0.0	0.3	-0.3	-0.3	-0.7	1.0	-0.2	-1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.1	0.6	0.6	0.8	0.9	0.5	0.6	0.1	1.4	1.1	0.7	0.5
Pain experienced in last month	0.3	0.4	1.4	-0.4	0.2	-0.3	0.2	-0.6	0.6	-1.2	-1.1	-0.5	-0.9	-0.2
Supplements: Calcium	0.9	0.9	2.9	0.7	-0.3	-1.6	-0.7	-1.0	-1.5	0.1	0.4	-0.7	0.0	-1.7
Basal cell carcinoma (self-reported)	2.6	3.1	6.2	0.1	2.1	2.2	1.8	2.0	1.1	1.1	1.7	2.5	1.7	1.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	1.1	0.2	0.5	0.3	-0.0	-0.2	0.8	1.1	0.3	-0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	10.5	-0.1	1.5	1.8	1.6	1.4	3.2	0.5	1.0	1.5	0.8	0.9
Heart disease (siblings)	0.3	0.3	2.7	-0.4	-0.3	0.2	-0.2	-0.1	-0.1	0.3	1.6	-0.4	-0.4	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.6	0.1	-0.2	0.1	-0.8	-0.4	-0.2	-0.1	0.1	0.2	0.1	-0.4
Pack years of smoking	0.1	0.1	0.5	0.0	-0.2	-0.2	0.3	0.1	-0.1	-0.4	0.7	-0.5	-0.6	0.1
Impedance of whole body	0.3	1.8	4.7	-0.5	-0.2	-2.0	-0.9	-1.4	-2.0	0.3	0.2	-2.2	-1.3	-1.4
Leg fat mass (left)	0.1	0.5	1.7	-0.6	-0.0	0.9	0.4	0.4	1.3	-0.2	0.6	1.2	0.2	0.7
Arm predicted mass (left)	0.3	1.3	4.0	-0.3	0.1	1.6	0.8	1.1	2.0	-0.1	0.6	1.9	0.7	1.4