Best TWAS P=2.16e-16 · Best GWAS P=7.17e-71 conditioned to 2.37e-71
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Cells Transformed fibroblasts | TBK1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.5e-05 | 8.09 | -8.2 | 2.2e-16 | -0.10 | 0.83 | 0.01 | TRUE |
| 6 | GTEx | Nerve Tibial | XPOT | 0.11 | 0.06 | enet | 15 | 0.07 | 8.6e-06 | -0.61 | -7.5 | 4.4e-14 | -0.04 | 0.79 | 0.01 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RASSF3 | 0.05 | 0.01 | lasso | 5 | 0.03 | 2.3e-04 | 2.31 | 6.5 | 6.0e-11 | -0.19 | 0.40 | 0.03 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | TBC1D30 | 0.10 | 0.03 | enet | 15 | 0.07 | 1.8e-08 | 4.63 | 5.7 | 1.3e-08 | 0.11 | 0.98 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C12orf66 | 0.05 | 0.03 | blup | 39 | 0.02 | 4.6e-03 | 7.03 | 5.6 | 1.9e-08 | 0.04 | 0.01 | 0.94 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TBK1 | 0.02 | 0.02 | blup | 58 | 0.01 | 7.7e-03 | 8.11 | -7.2 | 6.4e-13 | -0.14 | 0.08 | 0.04 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | XPOT | 0.02 | 0.01 | blup | 44 | 0.02 | 2.7e-03 | 8.11 | -6.9 | 5.0e-12 | -0.05 | 0.06 | 0.06 | FALSE |
| 5 | GTEx | Muscle Skeletal | TBK1 | 0.06 | 0.02 | enet | 13 | 0.02 | 7.2e-03 | 8.18 | -6.1 | 1.2e-09 | -0.04 | 0.84 | 0.01 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | FLJ41278 | 0.46 | 0.29 | bslmm | 340 | 0.38 | 1.4e-48 | -4.14 | 5.7 | 1.3e-08 | 0.10 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GNS | 0.05 | 0.03 | blup | 38 | 0.04 | 3.6e-03 | 4.16 | -5.2 | 2.1e-07 | -0.12 | 0.06 | 0.03 | FALSE |