TWAS hub - RASSF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.053	0.022	0.00210	0.012	0.024	0.024	0.027	0.028	1.0e-02	0.00052	0.00062	0.00026	0.00023
2	TCGA	Thyroid Carcinoma	0.044	0.021	0.00039	0.044	0.033	0.032	NA	0.022	3.5e-05	0.00033	0.00041	NA	0.00270

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	11.3	36.5	54.6	-4.3	-7.4
Pulse rate	8.5	14.4	16.3	-3.5	-4.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	7.2	8.5	8.9	-2.8	-3.0
Qualifications: NVQ or HND or HNC or equivalent	4.2	5.0	8.3	-1.3	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.2	3.0	1.9
Qualifications: CSEs or equivalent	3.0	4.0	4.2	-2.1	-1.9
Medication: Paracetamol	2.9	4.7	8.2	-1.1	-2.9
Stomach or abdominal pain in last month	2.7	3.4	6.4	-0.6	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.5	14.4	1.6	3.8
Eye problems/disorders: None of the above	2.5	2.9	4.6	-1.1	-2.1
Blood Platelet Count	2.4	28.0	42.8	6.5	3.6
Ever had prostate specific antigen (PSA) test	2.4	2.7	3.9	1.2	2.0
Supplements: Vitamin C	2.3	2.7	5.3	0.3	2.3
Fractured/broken bones in last 5 years	2.3	2.9	4.9	-2.2	-0.9
High blood pressure (mother)	2.2	3.0	3.7	1.9	1.6
Asthma	2.1	4.1	6.0	-2.5	-1.5
Medication for pain relief, constipation, heartburn	1.9	3.3	6.0	0.8	2.5
Asthma (self-reported)	1.9	3.9	5.0	-2.2	-1.6
Mean time to correctly identify matches	1.8	3.4	4.8	1.4	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.5	1.2	2.3
Medication: Paracetamol	1.7	2.6	4.5	-0.8	-2.1
Alzheimer’s Disease (in mother)	1.6	1.9	3.6	-1.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.2	-0.9	-1.8
Migraine (self-reported)	1.6	2.0	2.8	-1.7	-1.1
Medication: Ibuprofen	1.6	1.9	2.8	-1.0	-1.7
Type 2 Diabetes (T2D) (2018)	1.5	2.8	4.6	-1.0	-2.1
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	9.7	0.7	3.1
Forced vital capacity (FVC), Best measure	1.5	5.5	9.5	1.2	3.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.4	-1.8	-0.5
Smoking status: Current	1.5	2.4	4.0	-1.0	-2.0
Crohns Disease (2012)	1.4	2.3	3.2	-1.8	-1.2
Neuroticism (2016)	1.4	2.0	2.9	1.7	1.0
Age when periods started (menarche)	1.4	3.4	5.9	-2.4	-1.0
Had other major operations	1.4	1.7	3.3	1.8	-0.2
Illnesses of mother	1.4	1.7	2.6	-0.9	-1.6
Peak expiratory flow (PEF)	1.4	3.2	6.2	0.5	2.5
Wheeze or whistling in the chest in last year	1.4	2.6	4.0	-2.0	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.0	0.5	1.7
Heart disease (mother)	1.4	1.7	3.1	0.5	1.8
Smoking status: Previous	1.4	2.1	2.4	1.6	1.4
Risk taking	1.4	2.0	3.9	0.3	2.0
Townsend deprivation index at recruitment	1.3	1.8	3.1	-1.8	-0.8
Eye problems/disorders: Glaucoma	1.3	1.5	2.6	1.6	0.7
Age at First Birth	1.2	1.8	1.8	1.3	1.3
Had menopause	1.2	1.5	2.7	1.7	0.4
Medication: Ramipril	1.2	1.6	2.3	-0.9	-1.5
Glaucoma (self-reported)	1.2	1.4	2.3	1.5	0.7
Osteoarthritis (self-reported)	1.2	1.6	1.7	1.3	1.2
Hearing aid user	1.2	1.3	1.8	1.3	-0.9
Average weekly beer plus cider intake	1.2	1.7	2.9	-1.7	-0.7
Blood Eosinophil Count	1.1	8.2	10.2	-2.5	-3.2
Respiratory disease	1.1	2.4	2.7	-1.5	-1.6
Comparative body size at age 10	1.1	3.1	5.9	2.4	-0.5
Pulse wave peak to peak time	1.1	1.3	2.4	1.5	0.4
Qualifications: College or University degree	1.1	3.5	5.2	1.3	2.3
Overall health rating	1.1	2.3	3.0	-1.2	-1.7
Number of operations (self-reported)	1.1	1.6	3.3	1.8	0.1
Ever depressed for a whole week	1.1	1.4	1.5	1.1	1.2
Bipolar Disorder (2018)	1.0	1.6	1.9	1.4	1.1
Ovarian Cancer	1.0	1.3	2.2	1.5	0.6
Lung FEV1/FVC ratio	1.0	5.0	8.8	1.1	3.0
Forced vital capacity (FVC)	1.0	3.9	7.4	0.6	2.7
Blood clot in the leg (DVT)	1.0	1.3	1.5	1.2	1.0
Alcohol drinker status: Never	1.0	1.2	1.6	-1.0	-1.2
Diastolic blood pressure, automated reading	1.0	3.2	6.4	-0.3	-2.5
Major Depression (MDD)	0.9	1.1	2.2	1.5	0.2
Supplements: Zinc	0.9	1.0	2.0	-1.4	0.2
Diabetes (father)	0.9	1.2	2.3	-1.5	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.2	0.8	1.5
Pulse wave Arterial Stiffness index	0.9	1.0	2.0	-1.4	-0.2
Health satisfaction	0.9	1.1	1.4	0.9	1.2
Mood swings	0.9	1.5	1.9	1.4	1.1
Eye problems/disorders: Cataract	0.9	1.0	1.9	0.3	1.4
Mineral and other dietary supplements	0.9	1.3	1.6	-1.3	-1.0
Financial situation satisfaction	0.9	1.1	2.1	-1.5	-0.3
Depression (Nagel 2018)	0.8	1.2	2.1	1.4	-0.6
Bipolar Disorder (2011)	0.8	0.7	0.7	0.9	-0.8
Coronary Artery Disease (CAD)	0.8	1.0	1.2	-1.1	-0.9
Medication for hormone replacement therapy	0.8	0.9	1.5	1.2	0.6
Trunk fat percentage	0.8	3.2	3.7	-1.6	-1.9
Time employed in main current job	0.8	0.9	1.6	1.3	0.5
Alcohol intake versus 10 years previously	0.8	1.2	1.7	-1.3	-0.8
Worrier / anxious feelings	0.8	1.4	2.6	1.6	-0.5
Hair/balding pattern: Pattern 4	0.8	1.9	2.7	-1.1	-1.6
Arm fat percentage (left)	0.8	3.0	3.5	-1.6	-1.9
Commuting to job workplace: Walk	0.8	0.8	1.3	0.6	1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.6	1.3	0.7
High cholesterol (Self-reported)	0.8	1.5	2.6	-0.6	-1.6
Unable to work because of sickness or disability	0.8	1.0	1.3	-0.8	-1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	-1.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.9	1.4	0.4
Hearing difficulty/problems with background noise	0.7	1.2	1.7	1.3	0.9
Diabetes (self-reported)	0.7	1.0	1.6	-0.6	-1.3
Arm fat percentage (right)	0.7	2.6	2.9	-1.5	-1.7
Depression (self-reported)	0.7	0.8	1.4	1.2	0.4
Tense / ‘highly strung’	0.7	1.1	2.2	1.5	0.1
Body fat percentage	0.7	2.6	3.2	-1.4	-1.8
Had major operations	0.7	0.8	1.5	1.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.2	1.1	0.8
Fasting Glucose	0.6	0.7	1.3	-1.1	-0.2
Ulcerative Colitis	0.6	0.9	1.7	1.3	0.3
Tanning	0.6	7.9	12.2	-1.9	-3.5
Nervous feelings	0.6	1.2	2.3	1.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.6	1.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.3	1.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.4	-1.1
Standing height	0.6	6.4	11.6	1.1	3.4
Loud music exposure frequency	0.6	0.6	0.8	-0.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.3	-1.2	-0.3
Exposure to tobacco smoke outside home	0.6	0.7	1.0	-1.0	0.7
Number of full brothers	0.6	0.7	1.0	-0.7	-1.0
Emphysema/chronic bronchitis	0.6	0.7	0.7	-0.8	-0.8
Loneliness, isolation	0.6	0.9	1.4	-0.6	-1.2
Medication for cholesterol	0.6	1.0	1.7	0.5	1.3
Ever taken oral contraceptive pill	0.6	0.6	0.9	0.6	1.0
Supplements: Calcium	0.6	0.7	1.3	-0.3	1.1
Pack years of smoking	0.6	0.9	1.7	1.3	-0.2
Worry (Nagel 2018)	0.5	1.1	1.7	1.3	-0.7
Crohns Disease (2017)	0.5	1.1	1.3	-1.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	1.0	-0.3
Current tobacco smoking	0.5	0.8	1.7	0.1	-1.3
Serious illness, injury or assault to yourself	0.5	0.6	1.0	-1.0	0.5
Medication: Levothyroxine sodium	0.5	0.8	0.9	-0.8	0.9
Breastfed as a baby	0.5	0.6	1.2	1.1	0.1
Medication: Amlodipine	0.5	0.7	1.0	1.0	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.6	-0.8	-0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	-0.1	-1.0
Average weekly red wine intake	0.5	0.7	1.2	1.1	0.4
Breast cancer (self-reported)	0.5	0.6	0.8	-0.9	-0.7
Wears glasses or contact lenses	0.5	0.5	0.7	0.9	-0.6
Illnesses of father: High blood pressure	0.5	0.6	1.0	1.0	-0.5
Irritability	0.5	0.8	1.2	0.6	1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	1.1	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	0.6	0.9
Neuroticism (Nagel 2018)	0.4	0.8	1.5	1.2	-0.4
Reaction Time	0.4	0.7	1.5	-0.2	1.2
Waist Hip Ratio (WHR)	0.4	1.7	3.4	-0.3	-1.9
Average weekly spirits intake	0.4	0.5	0.7	0.5	0.8
Hearing difficulty/problems: Yes	0.4	0.7	1.2	1.1	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.4	0.8
Vitamin and mineral supplements	0.4	0.5	0.6	0.6	-0.8
Pack years adult smoking proportion	0.4	0.6	1.0	1.0	-0.4
Maternal smoking around birth	0.4	0.5	0.6	0.8	-0.7
Supplements: Glucosamine	0.4	0.5	0.8	0.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.8	0.5
Sitting height	0.4	2.8	5.2	0.6	2.3
Past tobacco smoking	0.4	0.7	0.9	-0.9	-0.7
Heart attack	0.4	0.6	0.6	0.7	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.9	-0.5	-0.9
Trunk fat-free mass	0.4	2.3	3.0	1.2	1.7
Hair/balding pattern: Pattern 3	0.4	0.6	0.8	-0.5	0.9
Trunk predicted mass	0.4	2.4	3.3	1.2	1.8
Length of working week for main job	0.4	0.5	0.6	0.6	-0.8
Headache pain in last month	0.4	0.7	1.2	-0.4	-1.1
Leg fat percentage (right)	0.4	1.3	1.8	-0.8	-1.4
Shortness of breath walking on level ground	0.4	0.5	1.0	-1.0	0.1
Number of full sisters	0.4	0.4	0.5	0.7	0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.6	0.7	0.8
Medication: Aspirin	0.4	0.5	1.0	1.0	0.0
Medication: Aspirin	0.4	0.6	1.0	1.0	0.4
Arm fat mass (left)	0.4	1.7	2.0	-1.2	-1.4
Commuting to job workplace: Public transport	0.4	0.5	1.1	-1.0	-0.0
Medication: Lisinopril	0.4	0.5	0.9	1.0	-0.4
Myopia	0.4	0.5	0.6	0.7	0.7
Cholesterol lowering medication	0.4	0.5	0.9	-0.4	-0.9
Pain experienced in last month	0.4	0.6	0.8	0.7	0.9
Heart disease (siblings)	0.4	0.5	0.6	0.7	0.6
HDL Cholesterol	0.3	0.5	0.6	-0.8	-0.6
Blood White Count	0.3	2.4	4.2	-0.8	-2.0
BMI	0.3	1.5	2.4	0.7	-1.5
Height	0.3	6.6	12.9	0.5	3.6
Neuroticism	0.3	0.7	1.4	1.2	-0.3
Number of treatments/medications taken	0.3	0.5	1.0	0.0	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.0	-0.9
Relative age of first facial hair	0.3	0.6	1.3	0.0	1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.2	0.8
Angina	0.3	0.4	0.5	0.5	0.7
Average weekly fortified wine intake	0.3	0.3	0.6	0.8	-0.2
Medication: Atenolol	0.3	0.4	0.9	0.9	-0.0
Body mass index (BMI)	0.3	1.3	2.2	-0.6	-1.5
Trunk fat mass	0.3	1.3	1.4	-1.1	-1.2
Waist circumference	0.3	1.1	1.9	-0.6	-1.4
Illnesses of siblings	0.3	0.4	0.6	-0.8	0.5
Neuroticism score	0.3	0.7	1.3	1.1	0.2
Noisy workplace	0.3	0.3	0.6	-0.0	0.8
Arm fat mass (right)	0.3	1.1	1.2	-1.0	-1.1
Pulse wave reflection index	0.3	0.4	0.8	0.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.9	-1.0	-0.3
Medication: Allopurinol	0.3	0.4	0.7	0.2	-0.9
Whole body fat mass	0.3	1.2	1.3	-1.0	-1.2
Age at last live birth	0.3	0.5	0.9	-0.9	-0.3
Illnesses of father: Heart disease	0.3	0.4	0.9	0.1	0.9
Ever had bowel cancer screening	0.3	0.3	0.6	0.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.5	-0.6	-0.7
Guilty feelings	0.3	0.4	0.7	0.3	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	0.6	-0.7
Leg fat percentage (left)	0.3	1.0	1.6	-0.6	-1.3
Bipolar Disorder or Schizophrenia	0.2	0.6	0.8	0.9	0.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	0.8	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.7	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.5	0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.7	-0.7	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	0.6	-0.4
HbA1C	0.2	0.2	0.4	-0.6	0.1
Lupus	0.2	0.3	0.4	-0.5	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.6	-0.2
Heel T-Score	0.2	1.4	1.6	-1.1	-1.3
Systolic Blood Pressure	0.2	0.9	1.7	-1.3	0.3
Smoking Status	0.2	0.4	0.8	0.9	-0.0
Lung FVC	0.2	0.9	1.0	0.9	1.0
Chronotype (morning person)	0.2	0.5	0.9	1.0	0.1
Hand grip strength (left)	0.2	0.5	0.6	-0.7	0.8
Medication: Metformin	0.2	0.3	0.7	-0.0	-0.8
Diabetes (mother)	0.2	0.2	0.5	0.7	-0.1
Relative age voice broke	0.2	0.4	0.5	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.9	0.3
Multivitamins +/- minerals	0.2	0.2	0.4	-0.7	0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.3	-0.7
Number of incorrect matches in round	0.2	0.3	0.5	0.7	0.2
Alcohol usually taken with meals	0.2	0.4	0.5	0.7	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.9	0.2
Allergy	0.2	0.6	0.9	1.0	0.5
Medication: Simvastatin	0.2	0.3	0.5	0.7	0.3
Number of live births	0.2	0.3	0.7	-0.8	-0.2
Prospective memory result	0.2	0.2	0.4	-0.1	-0.6
Lung cancer (father)	0.2	0.2	0.3	0.3	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.0	0.7
Birth weight of first child	0.2	0.3	0.5	0.3	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.7	-0.0
Worry too long after embarrassment	0.2	0.3	0.4	0.7	-0.4
Number of children fathered	0.2	0.2	0.4	-0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.3	0.6
Neck or shoulder pain in last month	0.2	0.2	0.5	-0.1	0.7
Angina (self-reported)	0.2	0.2	0.3	0.4	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	0.6
Comparative height size at age 10	0.2	0.9	1.2	0.7	1.1
Leg pain on walking	0.2	0.2	0.3	-0.3	0.6
Whole body fat-free mass	0.2	1.0	1.4	0.8	1.2
Long-standing illness, disability or infirmity	0.2	0.3	0.3	0.5	0.5
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.1	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.7	0.0
Whole body water mass	0.2	0.9	1.4	0.6	1.2
Mother’s age at death	0.2	0.3	0.4	0.5	0.6
Medication: Atorvastatin	0.2	0.3	0.6	-0.0	-0.7
Ever smoked	0.2	0.3	0.6	0.8	0.2
Age started oral contraceptive pill	0.2	0.2	0.4	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.3	-0.6	-0.6
Mean Putamen Volume	0.1	0.2	0.2	-0.4	-0.4
LDL Cholesterol	0.1	0.1	0.2	-0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.6	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.6	0.2
Blood Red Count	0.1	0.5	1.1	1.0	0.1
Allergy or Eczema	0.1	0.3	0.6	-0.8	-0.0
Cardiovascular Disease	0.1	0.2	0.3	-0.3	-0.6
Sensitivity / hurt feelings	0.1	0.2	0.5	0.1	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.3	-0.4
Hand grip strength (right)	0.1	0.3	0.4	-0.6	0.5
Fed-up feelings	0.1	0.1	0.2	-0.4	0.0
Taking other prescription medications	0.1	0.1	0.1	0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.7	-0.1
Qualifications: None of the above	0.1	0.2	0.3	-0.5	-0.2
Mouth/teeth dental problems	0.1	0.1	0.1	0.4	-0.3
Father’s age at death	0.1	0.2	0.2	0.3	-0.5
Falls in the last year	0.1	0.1	0.2	0.4	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.3	0.6
Medication: Lansoprazole	0.1	0.2	0.3	0.5	0.2
Impedance of arm (left)	0.1	0.4	0.8	-0.9	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.1	-0.4
Gout (self-reported)	0.1	0.2	0.3	-0.3	-0.5
Birth weight	0.1	0.2	0.3	0.1	0.6
Arm fat-free mass (right)	0.1	0.5	0.7	0.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.2	0.3
Age at first live birth	0.1	0.3	0.5	0.7	0.1
Medication: Omeprazole	0.1	0.1	0.2	0.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.5	-0.3
Leg fat mass (right)	0.1	0.4	0.6	-0.6	-0.7
Arm predicted mass (right)	0.1	0.5	0.6	0.8	0.6
Alcohol intake frequency.	0.1	0.2	0.3	-0.2	-0.6
Suffer from ‘nerves’	0.1	0.1	0.2	0.5	-0.1
Family relationship satisfaction	0.1	0.1	0.2	-0.5	0.2
Hypertension (Self-reported)	0.1	0.1	0.2	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.2	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	-0.3
Friendships satisfaction	0.1	0.2	0.2	-0.4	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.3	0.3	0.5
Medication: Gliclazide	0.1	0.1	0.1	-0.4	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	-0.4
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.6	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	0.1
Impedance of whole body	0.1	0.3	0.6	-0.8	-0.1
Leg fat mass (left)	0.1	0.2	0.4	-0.3	-0.6
Schizophrenia (2018)	0.0	0.0	0.0	0.1	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	-0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.1	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	-0.2
Triglycerides	0.0	0.0	0.0	0.2	0.2
Hypothyroidism (self reported)	0.0	0.0	0.1	0.3	-0.0
Hair Pigment	0.0	0.9	0.9	0.9	-1.0
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.2	-0.2
Medication: Co-codamol	0.0	0.1	0.1	0.2	-0.2
Severe depression (siblings)	0.0	0.0	0.0	-0.1	0.0
Impedance of leg (right)	0.0	0.1	0.1	-0.0	0.3
Leg fat-free mass (left)	0.0	0.1	0.2	0.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.1	-0.2
High blood pressure	0.0	0.1	0.1	-0.3	-0.2
Impedance of leg (left)	0.0	0.1	0.1	-0.1	0.4
Leg predicted mass (left)	0.0	0.1	0.1	0.1	0.4
Financial difficulties in last 2 years	0.0	0.1	0.1	-0.3	-0.0
Pain all over the body in last month	0.0	0.0	0.0	0.1	-0.1
Fluid intelligence score	0.0	0.1	0.1	0.3	0.2
Weight	0.0	0.0	0.0	-0.2	-0.0
Impedance of arm (right)	0.0	0.2	0.2	-0.5	0.3
Hip circumference	0.0	0.1	0.1	-0.4	-0.1
Happiness	0.0	0.0	0.0	0.2	0.0
Medication: Cholesterol lowering	0.0	0.1	0.1	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.2	0.1
High blood pressure (siblings)	0.0	0.0	0.0	0.2	-0.2
Medication: Blood pressure	0.0	0.0	0.1	-0.1	0.3
Chest pain or discomfort	0.0	0.1	0.1	-0.2	0.3
Knee pain experienced in last month	0.0	0.1	0.1	0.3	0.2
Leg fat-free mass (right)	0.0	0.1	0.2	-0.1	0.4
Back pain experienced in last month	0.0	0.0	0.0	-0.2	-0.0
Leg predicted mass (right)	0.0	0.1	0.2	-0.1	0.5
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.3	-0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.0	0.0
Miserableness	0.0	0.1	0.1	0.1	0.3
Medication: Blood pressure	0.0	0.0	0.0	0.1	-0.1
Basal metabolic rate	0.0	0.3	0.4	0.3	0.7
Arm fat-free mass (left)	0.0	0.2	0.2	0.3	0.5
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	-0.1
Alcohol drinker status: Previous	0.0	0.0	0.0	0.1	0.0
Arm predicted mass (left)	0.0	0.2	0.2	0.4	0.4

Hub : Genes

RASSF3

Models

Trait associations