TWAS hub - TBK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0670	0.0260	1.8e-03	0.062	NA	0.052	NA	0.064	1.9e-05	NA	8.9e-05	NA	1.5e-05
2	GTEx	Muscle Skeletal	0.0571	0.0233	2.4e-03	0.022	NA	0.017	NA	-0.002	3.0e-03	NA	7.2e-03	NA	5.4e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1050	0.0420	4.5e-03	0.035	NA	0.047	NA	0.025	7.0e-04	NA	8.8e-05	NA	3.2e-03
4	METSIM	Adipose	0.0912	0.0298	6.4e-06	0.071	0.035	0.063	0.057	0.059	7.2e-11	4.9e-06	9.5e-10	6.6e-09	3.1e-09
5	YFS	Blood	0.0577	0.0155	3.8e-10	0.044	0.040	0.043	0.049	0.042	3.2e-14	6.0e-13	4.7e-14	8.1e-16	1.0e-13
6	TCGA	Brain Lower Grade Glioma	0.0225	0.0131	8.0e-03	0.021	0.015	0.008	NA	0.011	1.9e-03	7.7e-03	4.1e-02	NA	1.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hypothyroidism/myxoedema (self-reported)	5.3	10.3	14.4	3.1	3.8	-2.2	3.3	2.8	3.8
Supplements: Zinc	4.7	5.1	7.4	2.2	2.7	-2.0	2.1	2.1	2.4
Hypothyroidism (self reported)	4.4	10.1	17.0	3.1	3.5	-2.2	3.0	2.8	4.1
Medication: Levothyroxine sodium	3.7	6.2	10.4	2.7	3.2	-1.4	2.5	2.1	2.6
Commuting to job workplace: Cycle	3.5	4.2	9.2	2.0	2.2	0.0	1.2	2.4	3.0
Guilty feelings	3.4	5.1	10.2	-3.2	-3.2	-1.2	-1.3	-1.8	-2.1
Emphysema/chronic bronchitis	3.2	3.6	6.3	-1.9	-1.8	2.2	-2.5	-1.4	-1.2
Heart disease (mother)	3.2	3.9	9.2	2.1	2.5	0.6	0.8	1.5	3.0
Mouth/teeth dental problems	3.0	4.6	7.5	1.7	2.7	-1.6	2.5	2.2	1.8
Triglycerides	2.9	4.8	7.7	2.4	2.4	-1.3	1.9	2.0	2.8
Other serious medical condition/disability diagnosed by doctor	2.8	3.7	5.5	1.4	1.7	-1.7	2.3	2.3	1.9
Medication: Co-codamol	2.7	3.2	8.1	-1.6	-2.2	1.4	-0.7	-1.0	-2.8
Worrier / anxious feelings	2.7	5.0	10.0	-2.7	-3.2	-0.2	-2.2	-1.9	-2.2
Frequency of depressed mood in last 2 weeks	2.5	3.5	8.6	-1.3	-2.9	0.2	-2.0	-1.6	-2.1
Blood Platelet Count	2.4	28.1	67.4	-8.2	-6.1	3.1	-0.0	-1.6	-7.2
Hair/balding pattern: Pattern 3	2.4	3.5	5.9	1.9	2.4	0.1	2.2	2.2	1.5
Birth weight of first child	2.4	4.4	6.5	2.6	2.2	-2.1	1.7	1.3	2.5
Hearing difficulty/problems with background noise	2.3	3.7	8.9	3.0	1.9	-1.5	-0.4	0.9	2.5
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	10.4	2.2	3.2	-1.1	2.1	2.5	1.7
Depression (Nagel 2018)	2.1	3.1	5.6	-1.0	-2.4	-1.3	-1.9	-1.9	-1.9
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	5.7	-1.6	-2.1	1.1	-0.9	-0.8	-2.4
Medication: Gliclazide	2.1	2.4	3.8	1.9	1.8	0.1	1.9	1.9	0.4
Ever had hysterectomy (womb removed)	2.0	2.2	3.6	-1.9	-1.6	0.9	-1.1	-1.4	-1.9
Depression (self-reported)	2.0	2.4	5.5	-2.3	-2.2	1.1	-0.3	-0.1	-1.7
Average weekly red wine intake	2.0	3.0	4.6	2.0	2.1	-1.6	1.4	1.5	1.7
Crohns Disease (2017)	1.9	4.2	8.4	-1.9	-2.5	0.3	-2.0	-1.7	-2.9
Qualifications: None of the above	1.9	4.1	7.0	-2.6	-2.1	2.6	-1.4	-1.2	-1.7
Trunk fat-free mass	1.9	10.7	18.2	3.5	4.2	0.2	2.9	2.7	4.3
Trunk predicted mass	1.9	10.7	18.2	3.5	4.2	0.2	2.9	2.7	4.3
Arm fat-free mass (left)	1.9	9.9	17.0	3.6	4.1	-0.4	2.6	2.6	4.0
Basal cell carcinoma (self-reported)	1.9	2.2	5.3	-2.3	-2.1	0.4	-0.8	-1.3	-1.1
Leg fat-free mass (left)	1.8	9.6	15.2	3.4	3.9	-0.1	3.2	3.0	3.3
Medication: Lansoprazole	1.8	2.1	3.5	-1.5	-1.1	1.9	-1.7	-1.5	-0.3
Medication: Amlodipine	1.8	2.6	6.5	-2.5	-1.9	0.7	-1.5	-1.5	-0.8
Whole body fat-free mass	1.8	10.4	17.0	3.6	4.1	0.0	3.1	2.8	3.9
Whole body water mass	1.8	10.4	17.1	3.6	4.1	0.1	3.1	2.8	3.9
Medication: Lisinopril	1.8	2.4	6.4	-1.0	-1.7	-1.3	-0.9	-1.3	-2.5
Waist Hip Ratio (WHR)	1.7	7.5	11.6	3.3	2.8	-1.1	2.4	2.9	3.4
Sitting height	1.7	11.8	18.3	3.3	4.3	-1.8	4.2	3.6	2.9
Leg predicted mass (left)	1.7	9.1	14.5	3.3	3.8	-0.1	3.2	3.0	3.2
Peak expiratory flow (PEF)	1.7	4.0	5.4	2.3	2.2	1.3	1.8	2.2	2.1
Had major operations	1.7	2.0	4.1	2.0	0.9	-1.6	0.7	0.4	2.0
Leg fat-free mass (right)	1.7	9.1	14.4	3.4	3.8	-0.2	3.2	3.0	3.0
Leg predicted mass (right)	1.7	9.0	14.2	3.3	3.8	-0.2	3.2	3.0	3.0
Basal metabolic rate	1.7	9.5	15.9	3.4	4.0	0.0	2.9	2.8	3.7
Arm predicted mass (left)	1.7	8.6	14.7	3.3	3.8	-0.1	2.5	2.6	3.6
Worry (Nagel 2018)	1.6	3.4	7.6	-1.7	-2.8	-0.4	-2.0	-1.6	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	6.8	1.0	2.6	-0.4	2.5	2.6	0.6
Neuroticism score	1.6	3.3	6.5	-2.1	-2.6	-0.8	-1.8	-1.5	-1.7
Noisy workplace	1.6	1.9	4.4	-0.0	-1.3	1.6	-2.1	-1.7	0.1
Asthma	1.6	3.1	8.4	-1.7	-0.7	1.8	1.5	1.2	-2.9
Arm predicted mass (right)	1.6	8.1	13.0	3.4	3.6	0.0	2.6	2.4	3.3
Age at last live birth	1.6	2.3	9.2	1.1	0.1	-3.0	1.5	1.0	-0.1
Asthma (self-reported)	1.6	3.3	10.3	-2.0	-1.0	1.6	1.0	0.8	-3.2
Supplements: Calcium	1.6	1.7	4.0	0.8	1.4	0.9	2.0	1.7	0.6
Average weekly spirits intake	1.5	1.9	3.6	1.7	1.9	1.4	0.1	1.0	1.3
Sensitivity / hurt feelings	1.5	2.6	4.5	-1.8	-2.1	0.8	-1.2	-1.1	-2.1
Fed-up feelings	1.5	2.7	5.6	-2.3	-2.4	-0.6	-0.9	-0.9	-1.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	5.7	1.9	0.8	-0.4	0.2	0.6	2.4
Medication: Allopurinol	1.5	2.0	8.7	1.4	0.8	-3.0	0.1	-0.7	0.6
Hearing aid user	1.5	1.7	3.3	-1.0	-1.3	0.6	-1.7	-1.8	-1.1
Pack years of smoking	1.5	2.3	4.7	-1.2	-1.3	0.9	-1.6	-2.2	-1.5
Neuroticism (Nagel 2018)	1.4	3.4	7.8	-2.1	-2.8	-1.3	-1.1	-1.5	-1.7
Lung FEV1/FVC ratio	1.4	7.2	16.8	2.9	3.2	-0.6	1.8	2.1	4.1
Neuroticism	1.4	3.3	6.9	-2.6	-2.3	-0.2	-0.8	-1.4	-2.2
Pack years adult smoking proportion	1.4	2.2	3.2	-1.3	-1.3	1.3	-1.5	-1.8	-1.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.6	1.9	1.4	-1.4	0.4	0.7	1.4
Standing height	1.4	13.6	21.3	4.3	4.6	-0.8	3.5	2.9	4.6
Pulse wave reflection index	1.4	1.7	3.6	0.3	1.4	1.2	1.9	1.7	-0.1
Arm fat-free mass (right)	1.4	7.3	11.9	3.1	3.5	0.1	2.4	2.4	3.3
Medication: Seretide 50 evohaler	1.4	1.6	2.5	-0.2	-0.9	1.6	1.2	1.6	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.1	-1.0	-2.0	0.1	-1.9	-2.0	-1.0
Respiratory disease	1.3	2.9	8.4	-2.1	-1.2	1.7	-0.1	-0.3	-2.9
Diabetes (father)	1.3	1.6	4.4	0.5	0.2	0.8	2.0	2.1	-0.4
Stomach or abdominal pain in last month	1.3	1.6	5.1	0.3	-1.3	-2.3	-1.4	-0.7	-0.8
Waist circumference	1.3	4.6	8.3	2.9	2.7	0.3	1.6	1.8	2.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.6	1.2	2.2	-0.5	1.5	0.7	0.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.3	-1.1	-1.5	-0.2	-1.4	-1.4	-1.3
Hearing difficulty/problems: Yes	1.2	1.8	4.1	2.0	0.5	-1.4	-1.5	-0.5	1.5
Number of incorrect matches in round	1.2	2.0	3.9	-1.3	-1.0	-0.9	-1.9	-2.0	-0.9
Weight	1.2	5.7	9.7	2.9	3.1	0.2	1.9	1.9	2.9
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.5	1.2	2.1	-0.7	0.8	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.4	1.9	0.9	-2.3	0.6	0.4	0.9
Chronic bronchitis/emphysema (mother)	1.2	1.3	3.0	-0.7	-0.5	1.7	-1.5	-0.9	-1.2
Shortness of breath walking on level ground	1.2	1.4	4.8	-0.7	-0.5	2.2	0.4	1.1	-1.2
Pulse rate, automated reading	1.2	3.9	11.4	2.1	1.7	-3.4	0.8	1.5	1.4
Illnesses of father: None of the above (group 1)	1.2	1.5	4.5	-0.4	-0.7	-0.5	-1.8	-2.1	0.6
Unable to work because of sickness or disability	1.2	1.5	3.5	-1.0	-0.4	1.9	1.2	1.7	-0.5
Crohns Disease (2012)	1.1	1.7	7.3	-0.8	-1.3	0.1	-0.6	-0.5	-2.7
Number of treatments/medications taken	1.1	2.0	3.6	-1.9	-1.7	1.1	-0.3	-0.7	-1.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.9	-0.7	-1.4	-0.5	-1.4	-1.2	-1.2
Vitamin and mineral supplements	1.1	1.4	4.0	0.1	-0.6	-0.7	-1.7	-2.0	0.8
Had other major operations	1.1	1.4	3.3	-0.7	-1.2	0.0	-1.8	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	7.9	2.1	2.0	0.2	1.3	1.4	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	4.8	-1.3	-2.2	1.0	-0.8	-0.3	-1.5
Medication: Omeprazole	1.1	1.3	2.7	-1.1	-1.4	0.3	-1.6	-1.1	-0.8
Ever had bowel cancer screening	1.1	1.2	3.5	1.0	1.0	-1.9	1.1	0.6	0.5
Eye problems/disorders: Cataract	1.1	1.3	4.3	0.3	0.3	0.2	2.1	1.8	0.5
Medication: Bendroflumethiazide	1.1	1.7	3.7	-0.9	-1.9	0.9	-1.3	-0.7	-1.7
Coronary Artery Disease (CAD)	1.0	1.2	3.7	-1.3	0.0	1.9	1.1	0.7	-0.1
Allergy or Eczema	1.0	2.6	7.0	2.6	1.6	-0.5	0.0	1.0	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	-0.4	-1.3	-0.5	-1.9	-1.0	-1.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.2	-0.3	-1.8	0.3	-1.2	-1.0	-0.7
Nervous feelings	1.0	1.8	3.5	-1.2	-1.9	-0.0	-1.8	-1.4	-0.9
Tense / ‘highly strung’	1.0	1.7	5.3	0.3	-1.4	-0.6	-2.3	-1.6	0.1
Blood clot in the leg (DVT)	1.0	1.3	7.7	-0.1	-0.0	2.8	0.4	-0.2	0.4
Gout (self-reported)	1.0	1.4	3.8	-0.1	-0.3	-1.7	-1.1	-1.9	-0.6
Eye problems/disorders: None of the above	1.0	1.1	2.7	-0.8	-0.5	-0.3	-1.2	-1.2	-1.6
Family relationship satisfaction	1.0	1.2	2.4	1.0	0.8	-1.1	1.3	1.6	0.7
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.4	0.3	1.3	-1.5	0.9	1.4	0.4
Long-standing illness, disability or infirmity	1.0	1.6	4.5	0.6	0.3	-0.4	2.1	2.1	0.3
Osteoarthritis (self-reported)	1.0	1.3	2.5	0.7	0.9	1.1	1.6	1.5	0.8
High cholesterol (Self-reported)	1.0	1.7	3.3	1.5	1.0	-1.5	0.8	1.0	1.8
Illnesses of father: High blood pressure	1.0	1.2	3.8	-0.8	-1.4	-0.2	0.3	0.7	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	7.2	-0.0	-0.0	2.7	0.6	0.2	0.5
Severe depression (siblings)	0.9	1.0	3.8	-0.2	-0.7	-0.6	1.9	1.2	-0.1
Townsend deprivation index at recruitment	0.9	1.3	2.4	1.1	1.6	-0.3	1.3	1.2	1.0
Relative age voice broke	0.9	1.3	2.3	-1.1	-1.5	-0.0	-0.8	-1.3	-1.5
Medication: Atenolol	0.9	1.2	2.4	-1.4	-1.5	-0.3	-0.7	-1.0	-1.1
Financial difficulties in last 2 years	0.9	1.2	2.4	-1.5	-1.6	0.9	-0.1	0.3	-1.1
High blood pressure (siblings)	0.9	1.3	4.2	-1.1	-1.1	-0.1	-0.7	-0.5	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.5	1.2	0.5	-1.9	-0.4	0.2	0.7
Qualifications: College or University degree	0.9	3.0	4.8	1.9	1.6	-2.2	1.8	0.9	1.6
Medication: Blood pressure	0.9	1.6	3.6	-1.9	-1.5	0.3	0.3	0.3	-1.8
Breast cancer (self-reported)	0.9	1.0	2.7	-0.3	-0.4	1.1	0.9	1.6	-1.2
Average weekly beer plus cider intake	0.9	1.4	3.0	-1.0	-0.8	1.7	-1.2	-0.6	-1.3
Depressed Affect (Nagel 2018)	0.8	1.6	2.9	-1.6	-1.6	-1.7	-0.0	-0.6	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	3.1	-0.7	-0.8	0.3	-1.8	-1.5	0.2
Height	0.8	14.8	26.0	5.1	5.0	0.5	2.9	2.3	4.9
Systolic Blood Pressure	0.8	4.1	9.6	-3.1	-2.6	1.1	-0.2	-0.1	-2.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	0.3	-0.7	1.4	-1.1	-0.7	1.4
Diabetes (mother)	0.8	1.1	4.1	-0.3	-0.1	2.0	-1.1	-1.0	0.0
Multivitamins +/- minerals	0.8	1.1	3.0	-0.5	0.2	0.2	1.7	1.7	-0.4
Alcohol usually taken with meals	0.8	1.4	4.2	1.3	0.8	-2.1	0.9	0.3	0.8
Pain all over the body in last month	0.8	0.9	3.1	-0.8	-1.1	0.4	-0.5	-0.4	-1.8
Illnesses of siblings	0.8	1.1	1.9	0.6	0.9	0.7	1.4	1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.5	-0.4	-1.6	0.9	-1.6	-0.6	-1.1
Illnesses of mother	0.8	0.9	2.3	-0.8	-0.3	-0.8	1.5	0.4	-1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	-0.9	-1.3	0.9	0.3	0.2	-1.6
Exposure to tobacco smoke outside home	0.8	1.1	2.4	1.6	0.8	-1.6	-0.5	1.0	0.2
Suffer from ‘nerves’	0.8	1.3	2.9	-1.2	-1.7	-0.3	-1.6	-0.8	-0.7
Number of self-reported non-cancer illnesses	0.8	1.5	3.2	1.1	0.6	-0.8	1.7	1.8	0.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.5	0.7	0.7	-1.2	-1.2	-0.9	1.0
Alcohol drinker status: Never	0.8	0.9	4.5	-0.8	-0.6	-0.0	-0.1	0.5	-2.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.2	1.5	0.9	-0.3	-0.2	-0.1	1.5
Alzheimer’s Disease (in mother)	0.7	0.9	1.6	1.3	1.1	0.5	0.3	0.9	1.1
Reaction Time	0.7	1.3	5.6	-0.9	-0.7	2.4	0.3	0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.7	1.1	1.0	-1.9	1.4	0.8	1.4
Ovarian Cancer	0.7	0.9	1.6	1.0	0.9	1.3	-0.8	-0.4	1.1
Bipolar Disorder (2011)	0.7	0.7	2.8	0.1	-0.2	-1.7	0.8	-0.3	-0.6
Lupus	0.7	1.0	1.8	-1.4	-1.2	0.9	0.2	0.4	-1.3
Schizophrenia (2014)	0.7	1.6	2.7	-1.7	-1.2	-0.1	-1.4	-1.6	-1.0
Impedance of leg (left)	0.7	3.3	5.5	-1.7	-2.0	-0.2	-2.3	-2.2	-1.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.4	-1.1	-1.5	0.8	-0.5	-0.4	-0.2
Falls in the last year	0.7	0.9	2.0	1.4	0.9	-0.9	0.6	1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.7	1.5	1.7	0.7	1.7	1.6	1.9
Hair/balding pattern: Pattern 4	0.7	1.8	6.0	1.1	1.5	-0.6	0.5	-0.7	2.4
Medication: Paracetamol	0.7	1.1	3.5	-1.9	-0.5	-0.8	0.2	-0.2	-1.5
Worry too long after embarrassment	0.7	1.1	1.7	-1.3	-1.3	-1.1	-0.6	-0.9	-0.9
Health satisfaction	0.7	0.9	1.3	1.1	0.8	0.6	-0.8	1.1	1.1
Number of full sisters	0.7	0.9	2.1	-0.2	-0.7	-0.1	-1.4	-1.4	0.7
Supplements: Vitamin C	0.7	0.8	3.1	0.5	0.3	1.8	0.6	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.5	1.3	0.6	-0.5	-1.2	-1.2	1.9
Commuting to job workplace: Walk	0.7	0.7	1.6	0.4	0.9	0.3	1.3	0.9	0.8
Average weekly champagne plus white wine intake	0.7	1.0	2.3	1.1	1.2	-0.2	1.5	0.8	-0.4
Ever taken oral contraceptive pill	0.7	0.8	2.5	-1.4	-0.2	1.6	0.5	0.2	0.0
Commuting to job workplace: Public transport	0.7	0.9	2.1	0.3	0.8	0.5	1.3	1.5	0.8
Medication: Blood pressure	0.7	1.3	2.9	-0.7	-1.4	1.7	-0.8	-0.6	-1.2
Ever smoked	0.7	1.3	2.2	1.4	0.6	0.8	-1.4	-0.7	1.5
Number of operations (self-reported)	0.7	1.0	2.6	0.8	-0.6	-0.7	-1.6	-1.4	-0.1
Heart disease (siblings)	0.7	0.8	2.4	0.6	-0.2	-0.8	-1.5	-1.0	0.7
Rheumatoid Arthritis	0.6	0.8	2.5	-0.4	-1.2	0.3	0.4	0.5	-1.6
Heel T-Score	0.6	4.5	10.2	1.0	2.3	-3.2	1.5	2.9	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	1.4	1.1	0.0	1.1	1.4	0.3
Hand grip strength (left)	0.6	1.7	3.3	1.7	1.8	-0.2	0.4	0.7	1.8
Relative age of first facial hair	0.6	1.3	3.6	-1.2	-1.5	0.3	-0.2	-0.5	-1.9
Impedance of leg (right)	0.6	3.0	5.5	-1.6	-1.9	0.0	-2.3	-2.1	-1.4
Average weekly fortified wine intake	0.6	0.7	2.3	0.9	0.4	-1.5	0.8	0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.4	-0.8	-1.2	0.6	-0.8	-0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.0	2.0	0.9	-0.1	-0.2	0.9	1.4
Heart attack	0.6	0.7	2.0	-1.0	-0.8	0.0	-0.3	-0.8	-1.4
Medication: Simvastatin	0.6	0.8	2.0	1.4	-0.0	0.6	-0.6	-0.6	1.4
Arm fat mass (right)	0.6	2.3	3.8	2.0	1.9	0.2	1.3	1.4	1.6
Headache pain in last month	0.6	1.0	1.7	0.8	1.3	-1.1	1.0	1.1	0.7
Age at first live birth	0.6	1.1	6.0	0.4	-0.0	-2.4	0.7	-0.1	0.1
Pulse wave peak to peak time	0.6	0.6	1.3	0.1	-0.3	-0.9	-1.1	-0.8	0.9
Neck or shoulder pain in last month	0.6	0.8	2.2	1.0	0.9	-0.9	0.2	0.6	1.5
Alcohol intake frequency.	0.6	1.3	3.6	-0.8	-1.6	0.2	-0.9	-0.3	-1.9
Chest pain or discomfort	0.6	0.9	3.1	-1.8	-0.8	0.0	0.7	0.8	-0.6
Knee pain experienced in last month	0.6	0.9	2.1	-0.1	1.0	0.4	1.4	1.2	0.8
Friendships satisfaction	0.6	0.8	1.5	-1.2	-1.1	0.6	-0.3	-0.0	-1.2
Osteoporosis (self-reported)	0.6	0.7	1.5	0.1	-0.8	-0.5	-1.0	-1.1	-1.2
Eye problems/disorders: Glaucoma	0.6	0.7	3.4	-0.6	-0.6	1.9	-0.2	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	-1.5	-0.9	0.4	-0.3	-0.0	-1.1
Medication: Paracetamol	0.6	1.0	3.6	-1.9	-0.4	-1.2	0.1	-0.1	-0.9
Impedance of whole body	0.6	3.0	4.4	-1.6	-1.9	-0.5	-1.8	-1.9	-2.1
Schizophrenia (2018)	0.5	1.0	2.3	-1.3	-0.9	-0.7	-0.9	-1.5	0.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	-1.2	-0.2	1.2	-0.4	-0.4	0.9
Irritable Bowel Disease (IBD)	0.5	1.3	2.5	-1.1	-1.5	0.3	-0.8	-0.8	-1.6
Age at First Birth	0.5	0.8	1.4	-0.5	-0.1	0.9	-1.2	-1.1	0.9
HDL Cholesterol	0.5	0.8	2.0	0.9	1.4	0.3	0.5	0.3	1.1
Medication for hormone replacement therapy	0.5	0.5	1.7	-1.3	-0.8	0.9	0.2	-0.2	-0.3
Taking other prescription medications	0.5	0.8	1.2	-0.3	-1.0	0.8	0.9	1.1	-1.1
Supplements: Glucosamine	0.5	0.7	2.5	-0.6	-1.0	1.6	0.2	-0.6	-0.2
Trunk fat mass	0.5	2.0	4.3	2.1	1.9	-0.5	1.3	1.0	1.2
Diabetes (self-reported)	0.5	0.7	1.8	1.3	1.0	0.6	0.5	0.8	0.0
Lung cancer (father)	0.5	0.5	1.2	-0.7	-1.1	-0.1	-0.5	-1.1	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	0.1	0.5	0.8	1.1	0.8	-0.8
Number of full brothers	0.5	0.6	1.8	0.3	0.9	1.4	0.6	0.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.3	-0.4	-1.5	0.4	-0.9	-0.0	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	0.6	0.0	1.6	-0.1	0.2	1.3
Whole body fat mass	0.5	2.2	4.0	2.0	1.9	-0.1	1.3	1.3	1.5
Leg fat mass (right)	0.5	1.9	3.3	1.8	1.8	0.3	1.1	1.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.7	-0.9	-0.5	1.3	0.3	0.6	-0.1
Illnesses of father: Heart disease	0.5	0.7	2.7	-0.7	-0.0	1.6	0.7	0.7	-0.2
Loneliness, isolation	0.5	0.7	1.7	-1.2	-0.9	-0.4	-0.4	-0.0	-1.3
Diabetes diagnosed by doctor	0.5	0.9	2.7	1.6	1.0	0.5	0.3	0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.3	-1.0	-0.9	1.0	-1.2	-1.5	0.5
Risk taking	0.5	0.8	1.5	0.9	0.5	0.9	1.0	0.5	1.2
Age started oral contraceptive pill	0.5	0.6	1.6	-0.8	-0.1	1.0	-0.5	-1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	-1.0	-0.7	-0.2	-0.2	-0.7	-1.4
Leg fat mass (left)	0.5	1.8	3.3	1.8	1.8	0.2	1.0	1.1	1.4
Bipolar Disorder (2018)	0.4	0.6	2.9	0.8	0.2	-1.7	0.3	-0.1	0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	2.7	-0.5	-0.6	-1.7	-0.5	-1.2	0.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.7	0.5	0.5	-2.2	1.2	0.2	1.0
Primary Biliary Cirrhosis	0.4	0.5	2.3	0.3	-0.2	1.5	-0.6	-0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.6	0.7	0.1	-0.9	-0.5	0.9
Chronotype (morning person)	0.4	0.8	3.6	-1.9	-0.8	0.4	0.1	-0.7	-0.3
Angina	0.4	0.5	1.7	-0.4	-0.1	1.0	1.3	0.6	0.1
Medication: Metformin	0.4	0.5	0.9	0.6	0.2	0.9	0.8	0.8	-0.9
Maternal smoking around birth	0.4	0.6	0.9	-0.8	-0.8	0.8	-0.6	-0.9	-0.6
Past tobacco smoking	0.4	0.7	1.4	-1.2	-0.2	-0.5	1.1	0.3	-1.1
Had menopause	0.4	0.4	1.5	-0.2	-0.2	1.0	-0.2	-1.2	-0.3
Pulse rate	0.4	0.6	2.5	0.4	-0.9	-1.6	-0.6	0.2	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.4	0.3	-1.0	1.2	-1.1	-0.4	-0.3
Impedance of arm (left)	0.4	1.9	2.8	-1.4	-1.6	-0.2	-1.3	-1.5	-1.7
Breastfed as a baby	0.4	0.6	1.5	1.2	0.3	1.1	-0.5	-0.4	0.3
Loud music exposure frequency	0.4	0.4	1.7	-0.3	-0.2	-1.3	0.5	0.4	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.3	2.9	1.1	1.2	0.5	1.0	0.9	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	-0.4	-0.8	-0.0	-0.7	-1.1	-0.3
Comparative height size at age 10	0.4	2.2	3.8	1.9	1.9	-0.6	1.4	0.8	1.9
Smoking status: Previous	0.4	0.7	1.7	1.2	0.3	-0.1	-0.9	-0.1	1.3
Medication for cholesterol	0.4	0.6	1.8	0.4	0.7	-1.3	0.9	0.7	0.4
Back pain experienced in last month	0.4	0.6	1.5	0.2	-1.2	0.1	-0.9	-0.9	-0.5
Arm fat mass (left)	0.4	1.7	2.9	1.7	1.6	0.3	1.1	1.2	1.4
Fractured/broken bones in last 5 years	0.4	0.6	1.2	-0.9	-0.5	0.5	0.6	0.7	-1.1
Ever depressed for a whole week	0.4	0.5	1.4	-0.2	-0.5	1.2	0.1	1.0	0.6
Major Depression (MDD)	0.3	0.4	1.0	-1.0	-0.8	-0.2	0.3	0.4	-0.4
LDL Cholesterol	0.3	0.5	1.0	0.5	0.5	-1.0	0.3	0.6	1.0
Smoking Status	0.3	0.7	1.8	0.6	0.7	1.0	-0.4	-0.5	1.3
Cardiovascular Disease	0.3	0.9	1.9	-1.0	-1.4	1.1	-0.5	0.3	-1.0
Lung FVC	0.3	1.4	2.4	-1.5	-1.4	0.3	-0.8	-1.3	-1.4
Systolic blood pressure, automated reading	0.3	1.0	2.4	-1.5	-1.3	-0.2	-0.5	-0.9	-0.8
Hand grip strength (right)	0.3	0.9	1.8	1.3	1.1	-0.1	0.3	0.7	1.4
Current tobacco smoking	0.3	0.5	1.4	-0.0	1.2	0.3	0.4	-0.3	1.1
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-0.2	-1.0	0.4	0.2	0.8	-0.7
High blood pressure	0.3	0.9	2.5	-1.1	-1.3	0.0	-0.3	0.0	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.4	-1.0	-0.5	-0.9	-0.3	0.6
Impedance of arm (right)	0.3	1.4	2.5	-0.9	-1.2	-0.5	-1.4	-1.6	-1.1
Father’s age at death	0.3	0.4	0.8	0.5	0.8	-0.7	0.6	0.9	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.9	0.5	0.3	-1.4	0.9	0.6	1.1
Medication: Cholesterol lowering	0.3	0.5	1.1	1.0	0.6	-0.4	0.4	0.6	1.1
Glaucoma (self-reported)	0.3	0.4	1.6	-0.5	-0.5	1.3	0.0	0.2	-0.3
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	-0.6	0.2	1.4	-0.2	0.5	0.1
Angina (self-reported)	0.3	0.4	1.7	-0.3	-0.1	0.6	1.3	0.5	0.3
Migraine (self-reported)	0.3	0.3	1.3	-0.8	-0.1	1.1	0.4	0.1	-0.3
Medication: Ibuprofen	0.3	0.3	1.1	-0.1	1.0	-0.8	0.4	0.4	0.1
Mean time to correctly identify matches	0.3	0.6	1.9	-0.7	-0.6	1.4	-0.5	-0.6	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.8	-0.0	-0.6	-0.7	-0.9	-0.3
Illnesses of siblings: Diabetes	0.3	0.3	1.1	1.0	0.5	-0.1	-0.4	-0.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.2	0.6	-0.1	1.1	0.6	0.3	0.2
Miserableness	0.3	0.5	2.0	0.3	0.3	-1.4	-0.1	0.2	0.7
Wears glasses or contact lenses	0.3	0.3	1.3	-0.3	-0.4	0.2	-0.5	-1.1	-0.2
Mother’s age at death	0.3	0.3	0.7	-0.6	-0.6	-0.8	0.8	-0.1	-0.3
Myopia	0.3	0.5	1.6	0.9	0.4	-1.3	0.5	0.2	0.1
Alzheimer’s Disease (in father)	0.2	0.3	1.1	0.4	0.4	-1.1	0.2	0.1	0.1
Alzheimer’s Disease (including proxy)	0.2	0.4	1.0	1.0	0.6	0.2	0.2	0.6	0.6
Mean Putamen Volume	0.2	0.3	0.4	-0.7	-0.6	-0.3	-0.5	-0.5	-0.6
Fasting Glucose	0.2	0.2	0.4	-0.5	-0.7	-0.4	0.4	0.2	0.4
HbA1C	0.2	0.2	0.6	-0.5	0.1	0.5	-0.8	-0.3	0.1
Neuroticism (2016)	0.2	0.3	1.0	0.1	-0.6	-1.0	0.3	0.1	-0.6
Blood Eosinophil Count	0.2	1.6	3.0	1.1	0.7	1.4	1.6	1.7	-0.4
Blood White Count	0.2	1.1	3.9	2.0	0.4	0.4	-0.8	0.5	1.3
Trunk fat percentage	0.2	0.6	2.0	1.4	1.0	-0.7	0.5	0.3	0.4
High blood pressure (mother)	0.2	0.2	0.5	-0.5	-0.7	-0.2	-0.6	-0.4	0.2
Body mass index (BMI)	0.2	0.8	1.6	1.3	1.2	0.6	0.4	0.7	0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.1	-0.6	-0.0	-0.7	0.5	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.2	0.4	0.8	0.8	1.1	0.9	1.0
Medication: Ramipril	0.2	0.3	1.1	-0.1	0.2	1.1	-0.3	-0.4	0.2
Fluid intelligence score	0.2	0.3	1.4	0.2	0.1	-1.2	0.4	-0.2	0.6
Hip circumference	0.2	0.9	1.6	1.2	1.3	0.8	0.8	0.4	1.0
Time employed in main current job	0.2	0.3	0.7	-0.0	0.0	0.1	0.9	0.8	0.5
Alcohol intake versus 10 years previously	0.2	0.4	0.9	0.5	0.7	-0.2	0.9	0.7	0.3
Happiness	0.2	0.3	0.9	0.4	-0.3	-1.0	0.1	0.6	-0.3
Prospective memory result	0.2	0.3	0.9	-0.2	-0.5	0.9	0.1	-0.0	-0.8
Length of working week for main job	0.2	0.3	1.0	1.0	0.3	-0.4	-0.5	0.2	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.1	-0.5	-0.3	-1.0	0.2	-0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	-0.0	-0.3	0.4	-0.6	-1.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	0.6	1.0	-0.7	-0.2	-0.4	0.6
Leg pain on walking	0.2	0.3	0.8	0.1	-0.2	0.9	-0.1	0.6	-0.5
Medication: Aspirin	0.2	0.3	1.4	0.2	-0.2	-1.2	0.5	-0.1	-0.1
Mood swings	0.2	0.4	1.9	-0.4	-1.4	0.4	-0.5	-0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.3	-0.4	-1.0	-0.3	0.3	-0.3
Mineral and other dietary supplements	0.2	0.3	0.6	0.1	0.7	-0.4	0.4	0.8	-0.0
Medication: Aspirin	0.2	0.2	0.8	-0.1	-0.2	-0.9	0.5	-0.2	-0.4
Smoking status: Current	0.2	0.3	1.1	-0.2	1.0	0.4	0.3	-0.3	0.7
Financial situation satisfaction	0.2	0.2	0.4	0.2	-0.2	0.5	-0.2	0.6	-0.6
Medication: Atorvastatin	0.2	0.3	0.5	0.4	0.1	-0.5	0.6	0.7	-0.4
Irritability	0.2	0.4	1.5	-0.5	-0.7	-1.2	-0.0	-0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.7	0.9	1.2	-0.2	0.2	0.1	1.3
Cholesterol lowering medication	0.2	0.2	1.2	1.1	0.4	-0.0	0.0	-0.0	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.0	-0.2	0.4	0.9	0.4	-0.2
Ulcerative Colitis	0.1	0.1	0.2	0.5	0.2	0.3	0.0	-0.3	-0.0
Blood Red Count	0.1	0.9	2.3	1.5	0.9	1.2	-0.5	0.6	0.4
Tanning	0.1	0.9	3.6	-0.5	0.8	0.5	1.9	0.7	-0.4
Age when periods started (menarche)	0.1	0.3	0.9	-0.0	0.0	-0.6	0.9	0.8	-0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.4	0.2	-0.4	0.2	0.8	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	-0.7	0.1	0.3	-0.4	-0.3	-0.2
Allergy	0.1	0.2	0.7	-0.1	0.2	-0.8	0.6	0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.5	-0.1	0.5	0.6	0.1	-0.5
Arm fat percentage (right)	0.1	0.5	0.9	0.9	0.9	0.4	0.6	0.6	0.5
Number of live births	0.1	0.2	0.5	-0.2	0.4	0.3	0.7	0.5	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.6	0.0	0.5	-0.3	0.1	0.0
Birth weight	0.1	0.2	0.6	0.0	0.2	-0.8	-0.1	-0.2	-0.5
Body fat percentage	0.1	0.3	0.9	1.0	0.8	-0.0	0.3	0.3	0.3
Leg fat percentage (right)	0.1	0.3	1.6	0.1	0.3	1.3	-0.4	-0.0	0.1
Number of children fathered	0.1	0.1	0.2	-0.0	-0.0	-0.3	-0.3	-0.4	-0.5
Overall health rating	0.1	0.2	0.5	0.0	-0.3	-0.5	-0.3	0.7	-0.5
Hypertension (Self-reported)	0.1	0.4	1.1	-0.5	-0.8	-0.3	0.1	0.5	-1.1
Arm fat percentage (left)	0.1	0.3	0.5	0.7	0.6	0.6	0.5	0.6	0.1
Qualifications: nursing, teaching	0.1	0.1	0.7	-0.3	0.1	-0.9	0.3	-0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	0.2	-0.1	0.5	-0.5	-0.7	0.4
Leg fat percentage (left)	0.1	0.2	1.0	0.2	0.4	1.0	-0.4	-0.1	0.1
Diastolic blood pressure, automated reading	0.1	0.4	1.5	-0.4	-0.6	-1.2	-0.3	-0.5	-0.3
Pain experienced in last month	0.1	0.1	0.3	-0.5	0.3	0.4	0.1	-0.1	0.5
Alcohol drinker status: Previous	0.1	0.1	0.3	0.1	-0.1	0.5	0.4	-0.1	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.0	0.2	-0.1	-0.2	0.4	-0.0	0.1	0.0
Hair Pigment	0.0	1.2	3.7	0.0	-0.5	-1.9	-1.0	-1.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.2	0.3	0.4	0.1	-0.1	0.0	0.2
Comparative body size at age 10	0.0	0.1	0.3	-0.5	-0.1	0.1	-0.0	-0.4	-0.3

Hub : Genes

TBK1

Models

Trait associations