Hub : Genes

KBTBD7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1160	0.0460	0.0026	-0.003	NA	0.007	NA	0.035	8.0e-01	NA	9.4e-02	NA	1.2e-03
2	GTEx	Testis	0.1790	0.0630	0.0013	0.108	NA	0.069	NA	0.075	1.7e-05	NA	5.6e-04	NA	3.2e-04
3	NTR	Blood	0.0261	0.0111	0.0036	0.008	0.011	0.018	0.012	0.016	7.7e-04	1.2e-04	1.5e-06	5.3e-05	5.5e-06
4	YFS	Blood	0.1256	0.0234	0.0000	0.116	0.103	0.112	0.116	0.116	7.1e-36	7.3e-32	9.3e-35	7.0e-36	5.6e-36

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.1	0.9	-0.2	-0.4	1.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	0.3	0.4	0.4	0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-1.3	0.5	-0.7	-0.5
Depression (Nagel 2018)	0.5	0.7	1.9	0.3	1.4	-0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.6	0.3	-1.9	0.7	0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.9	-0.6	-0.4	-0.2
Schizophrenia (2018)	0.2	0.4	0.6	-0.3	0.8	0.8	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.4	-0.6	0.7	0.0
Worry (Nagel 2018)	1.1	2.2	4.7	0.8	-2.2	0.6	1.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-0.3	-0.5	-0.3	1.3
Alzheimer’s Disease (in father)	1.8	2.0	5.0	-0.5	-2.2	1.4	0.9
Alzheimer’s Disease (including proxy)	1.5	2.2	4.0	-0.5	-2.0	0.9	1.9
Crohns Disease (2017)	0.7	1.5	3.2	-0.1	-0.9	1.8	1.4
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	-0.1	0.3	1.0	0.0
Ulcerative Colitis (UC)	0.3	0.7	1.5	0.2	1.2	0.1	-1.0
Major Depression (MDD)	1.6	1.9	3.2	1.5	-0.2	1.8	1.5
Reaction Time	1.4	2.6	4.5	1.2	-0.7	2.0	2.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.0	-0.1	-2.5	0.2	1.5
Breast Cancer	2.4	5.7	12.2	-0.7	3.5	-1.7	-2.7
Ovarian Cancer	0.5	0.7	1.3	0.0	1.1	0.4	1.1
Prostate Cancer	1.6	2.2	5.0	-1.1	2.2	0.1	-1.6
Age at First Birth	0.3	0.4	0.7	-0.8	-0.6	0.3	-0.6
Bipolar Disorder (2011)	2.5	2.4	4.9	1.2	-0.5	1.7	2.2
Body Mass Index (BMI) (2010)	0.9	1.2	3.1	-0.4	1.3	-0.4	-1.8
Coronary Artery Disease (CAD)	1.4	1.7	3.2	1.4	-1.3	-0.1	1.8
Crohns Disease (2012)	0.6	1.0	2.0	0.1	-1.0	0.9	1.4
Mean Putamen Volume	0.7	0.8	1.0	0.9	-0.8	-0.7	-1.0
Fasting Glucose	1.0	1.2	3.9	0.7	-0.1	2.0	0.5
HbA1C	1.5	1.7	3.4	0.1	1.7	0.7	-1.8
HDL Cholesterol	0.6	1.0	3.9	-2.0	0.0	-0.2	-0.5
LDL Cholesterol	0.7	1.2	1.7	-0.3	1.3	1.3	-1.1
Lupus	0.3	0.5	1.0	-0.6	-1.0	0.4	-0.8
Neuroticism (2016)	1.1	1.6	3.0	0.2	-1.7	-1.2	1.4
Primary Biliary Cirrhosis	0.2	0.3	1.0	1.0	0.0	-0.4	-0.2
Rheumatoid Arthritis	0.6	0.8	1.7	0.5	0.8	-1.3	-0.8
Schizophrenia (2014)	0.1	0.3	0.6	0.1	-0.3	0.8	0.7
Triglycerides	0.5	0.8	1.4	1.2	0.8	-0.8	-0.9
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.9	2.0	-0.8	1.4	1.1
Ulcerative Colitis	0.9	1.3	4.3	-0.1	2.1	0.3	-0.8
Blood Eosinophil Count	0.5	4.2	9.6	-1.7	3.1	1.5	-1.3
Blood Platelet Count	2.1	24.8	51.1	-2.9	7.1	-1.7	-6.0
Blood Red Count	1.0	10.0	23.8	0.9	2.7	-2.9	-4.9
Blood White Count	0.2	1.7	3.2	-1.8	1.3	0.1	-1.3
Heel T-Score	0.4	3.5	12.3	1.0	-0.4	3.5	0.8
BMI	0.2	1.0	1.9	-0.6	0.1	1.4	-1.4
Height	0.7	13.8	31.7	2.2	-3.4	2.6	5.6
Waist Hip Ratio (WHR)	0.2	0.8	3.1	0.5	0.0	0.3	-1.7
Systolic Blood Pressure	0.3	1.4	4.2	2.0	-1.1	0.2	-0.3
Smoking Status	0.4	0.9	2.2	-0.7	0.9	-0.5	-1.5
Allergy or Eczema	0.2	0.6	1.4	-0.1	-0.7	-0.7	1.2
Cardiovascular Disease	0.0	0.1	0.2	0.0	0.2	-0.5	0.2
Hypothyroidism (self reported)	0.4	0.9	3.4	0.2	1.8	0.3	-0.3
Respiratory disease	0.3	0.7	1.5	0.8	0.6	-0.6	1.2
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.0	1.4	-0.2	1.8	2.0
Lung FEV1/FVC ratio	0.2	1.0	2.0	-1.0	0.2	1.4	-1.0
Lung FVC	0.1	0.7	1.7	-1.3	0.1	-0.2	1.0
Neuroticism	0.4	1.0	2.0	0.4	-1.4	0.7	1.1
Chronotype (morning person)	1.0	2.4	7.1	-1.1	-0.5	-2.7	1.0
Hair Pigment	0.0	0.4	1.3	-0.4	0.4	1.1	0.1
Tanning	0.1	0.7	1.1	-0.9	1.0	-1.1	-0.1
Hand grip strength (left)	0.0	0.1	0.1	-0.2	-0.3	-0.1	0.2
Number of treatments/medications taken	1.5	2.6	5.3	2.3	1.8	0.9	-1.2
Average weekly spirits intake	1.1	1.4	3.5	-0.5	1.9	1.3	-0.2
Sensitivity / hurt feelings	0.4	0.7	1.2	-0.9	0.8	0.3	-1.1
Frequency of depressed mood in last 2 weeks	1.4	1.9	5.0	0.2	1.6	-0.5	-2.2
Hearing difficulty/problems: Yes	0.5	0.8	2.0	0.8	0.5	1.4	-0.3
Relative age of first facial hair	1.3	2.7	5.7	0.8	-1.7	1.3	2.4
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	11.8	-2.2	3.4	-1.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	0.5	0.3	-0.5	-1.3
Ever had hysterectomy (womb removed)	1.6	1.8	4.3	-0.8	0.8	-2.1	-1.2
Systolic blood pressure, automated reading	0.4	1.0	1.4	0.9	-1.2	1.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.5	0.6	0.7	0.6	0.5
Angina	0.8	1.1	3.0	1.7	0.0	-1.0	0.7
Medication for hormone replacement therapy	1.2	1.4	4.7	-0.1	0.6	-0.7	-2.2
Vitamin and mineral supplements	1.1	1.5	3.2	-1.2	0.4	-1.8	-1.2
Supplements: Zinc	0.3	0.4	1.3	1.1	0.2	-0.3	-0.1
Medication: Co-codamol	0.7	0.8	1.6	0.6	-0.8	-1.3	-0.5
Medication: Metformin	2.8	4.0	7.1	2.2	0.0	2.7	2.0
Diabetes (father)	0.7	0.9	2.0	0.9	0.9	-0.1	-1.4
Diabetes (mother)	0.2	0.2	0.8	0.1	0.9	-0.1	-0.4
Severe depression (siblings)	0.5	0.6	1.5	-1.2	-0.6	-0.6	-0.3
Pack years adult smoking proportion	0.3	0.4	1.2	-0.0	-0.1	-0.6	-1.1
Impedance of leg (right)	0.7	3.6	13.8	-0.4	0.6	-3.7	0.3
Leg fat-free mass (left)	0.6	3.1	8.3	1.5	-1.3	2.9	0.5
Trunk fat percentage	0.1	0.3	0.8	0.2	0.6	0.1	-0.9
Hand grip strength (right)	0.0	0.1	0.1	0.1	-0.3	0.3	0.4
Townsend deprivation index at recruitment	0.3	0.4	0.6	-0.3	-0.5	0.8	0.8
Current tobacco smoking	0.9	1.5	3.1	-1.2	0.4	-1.8	-1.1
Average weekly fortified wine intake	2.1	2.5	5.5	-2.0	2.4	-0.4	0.1
Maternal smoking around birth	0.2	0.3	0.3	0.6	0.4	-0.5	-0.5
Fed-up feelings	0.8	1.5	3.2	-1.3	0.3	-1.0	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	3.3	-0.0	1.3	-0.1	-1.8
Relative age voice broke	0.1	0.1	0.4	-0.2	0.6	0.4	-0.1
Taking other prescription medications	1.2	1.9	3.8	0.0	1.9	1.9	0.5
Age when periods started (menarche)	0.3	0.6	2.0	-0.0	-1.4	-0.1	0.7
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.4	-1.7	1.2	-0.4	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.5	0.3	0.7	-0.2	-1.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.3	-0.6	0.4	1.1
Qualifications: CSEs or equivalent	0.4	0.5	1.7	-0.3	-0.4	-0.2	-1.3
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-0.2	1.0	-0.4	-1.1
High blood pressure	0.4	1.0	1.5	1.1	-0.3	1.2	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.7	-0.0	-1.2	-1.7	1.0
Multivitamins +/- minerals	1.8	2.3	5.5	1.2	-0.2	2.3	1.5
Stomach or abdominal pain in last month	0.5	0.6	1.7	0.0	1.3	-0.7	-0.3
Supplements: Glucosamine	1.0	1.4	4.3	0.8	0.6	-0.4	-2.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.1	-1.0	0.3	0.6	1.4
Medication: Atenolol	0.4	0.5	1.8	1.3	-0.4	-0.0	0.1
Medication: Levothyroxine sodium	0.7	1.1	2.7	-0.4	1.7	0.9	-0.9
Sitting height	0.2	1.3	4.0	0.8	-0.4	0.7	2.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.4	-0.4	-0.2
High blood pressure (mother)	0.5	0.7	1.7	1.3	0.7	-0.5	-0.5
Body mass index (BMI)	0.3	1.2	2.6	0.5	-0.0	1.6	-1.4
Impedance of leg (left)	0.8	3.8	12.0	-1.2	1.3	-3.5	-0.3
Leg predicted mass (left)	0.6	3.0	8.3	1.4	-1.2	2.9	0.4
Trunk fat mass	0.1	0.4	0.8	0.5	0.4	0.9	-0.6
Waist circumference	0.4	1.6	3.6	0.8	0.0	1.9	-1.5
Number of incorrect matches in round	0.5	0.8	1.1	-1.0	0.6	-1.0	0.8
Past tobacco smoking	0.6	1.2	3.8	0.1	-1.9	-0.9	-0.2
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	0.4	-0.5	0.0
Nervous feelings	0.5	0.9	1.9	-0.5	-1.2	-1.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.6	0.2	0.5	-1.6	-1.5
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.0	0.7	0.2	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.8	0.2	-0.6	-0.7
Had menopause	0.8	1.0	2.4	-0.9	-0.8	-0.1	1.5
Had other major operations	0.7	0.8	1.7	1.3	0.7	-1.0	-0.5
Forced vital capacity (FVC)	0.2	0.7	1.1	-1.0	-1.0	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.1	0.2	2.0	0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.3	0.6	0.4	0.1
Qualifications: None of the above	0.6	1.2	2.1	-1.1	-0.6	-1.5	0.9
Financial difficulties in last 2 years	0.6	0.8	2.9	-0.0	-0.2	0.4	-1.7
Mouth/teeth dental problems	0.6	0.9	1.9	1.4	-0.9	0.6	-0.7
Heart attack	0.6	0.8	2.1	0.7	-0.6	0.4	1.4
Allergy	0.5	1.2	3.5	0.1	0.0	1.9	-1.2
Pain all over the body in last month	1.3	1.4	2.6	1.0	1.6	-0.5	-1.4
Diabetes (self-reported)	1.7	2.6	5.2	2.3	-0.5	1.3	1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-1.0	-0.3	-0.1	1.2
Medication: Ramipril	0.3	0.4	0.6	0.6	-0.7	0.6	0.5
Medication: Simvastatin	2.1	3.1	9.2	3.0	-0.6	-0.5	-1.6
Fluid intelligence score	0.5	1.1	2.3	-0.3	-1.5	-0.3	1.4
Illnesses of siblings	0.3	0.5	1.8	0.0	-0.1	-0.2	-1.3
Neuroticism score	0.3	0.7	1.6	-0.5	-1.3	-0.8	0.6
Weight	0.4	2.0	6.1	1.2	-0.8	2.5	0.1
Impedance of arm (right)	0.4	2.1	7.1	-0.8	0.2	-2.7	0.7
Arm fat percentage (right)	0.1	0.6	1.6	0.3	0.7	0.3	-1.3
Trunk fat-free mass	0.9	5.2	12.0	1.6	-1.8	3.5	1.7
Hip circumference	0.3	1.2	3.5	1.0	-0.5	1.9	0.0
Time employed in main current job	1.4	1.6	5.1	2.3	-0.7	0.7	0.5
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-0.1	-1.1	0.1	0.4
Father’s age at death	0.1	0.2	0.3	-0.4	-0.3	0.4	-0.6
Worrier / anxious feelings	0.8	1.5	3.6	0.7	-1.4	-0.2	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-0.1	0.4	-0.6	-1.1
Falls in the last year	0.6	0.9	2.0	-1.0	-0.5	-1.4	-0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	0.1	0.8	1.4	0.0
Number of live births	0.2	0.3	1.0	-1.0	0.4	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.7	-1.3	-1.2	-0.1	0.6
Pulse rate	1.4	2.3	3.9	-1.1	2.0	-0.9	-1.8
Happiness	0.7	0.9	2.8	0.8	0.1	1.7	0.3
Noisy workplace	0.9	1.1	1.4	1.0	1.0	-1.0	-1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.0	0.7	-0.4	0.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.1	-0.2	-0.3	0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	5.7	-0.6	-0.6	1.7	2.4
Asthma	0.5	0.9	2.1	-0.1	1.0	-0.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	-0.0	-0.0	0.5	-1.4
Medication: Cholesterol lowering	1.0	1.6	3.8	1.9	0.7	1.5	-0.1
Depression (self-reported)	1.5	1.8	3.9	-0.6	1.6	-0.5	-2.0
Medication: Lansoprazole	0.4	0.5	1.4	0.6	-0.0	1.2	0.5
Prospective memory result	0.9	1.1	2.1	1.0	0.9	-0.8	-1.4
Lung cancer (father)	1.6	1.9	4.2	-1.1	1.3	-2.0	-0.8
Illnesses of mother	0.1	0.1	0.1	-0.1	-0.3	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.3	-1.4	-1.8	-0.0	1.1
Pulse wave Arterial Stiffness index	2.0	2.3	6.3	-2.5	1.1	0.4	1.2
Impedance of arm (left)	0.4	1.6	5.8	-0.6	0.3	-2.4	0.6
Arm fat mass (right)	0.2	0.6	1.7	0.5	0.1	1.3	-0.7
Trunk predicted mass	0.9	5.2	12.0	1.5	-1.9	3.5	1.8
Standing height	0.4	4.2	9.3	1.2	-1.6	1.8	3.1
Length of working week for main job	2.5	2.8	5.3	-1.0	-2.3	-1.6	1.6
Exposure to tobacco smoke at home	0.4	0.4	0.8	-0.8	0.1	-0.9	0.4
Breastfed as a baby	0.2	0.3	0.4	0.7	-0.5	0.5	-0.2
Tense / ‘highly strung’	0.4	0.6	1.1	0.9	-1.0	-0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.4	0.6	1.2	-0.7	-0.6
Hair/balding pattern: Pattern 4	0.8	1.9	3.6	0.2	-1.6	1.9	1.1
Birth weight of first child	1.6	2.9	7.8	-0.8	-0.7	-2.8	-1.7
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.6	-0.4	0.7	0.2
Pulse wave reflection index	1.4	1.7	5.7	-2.4	-0.1	-0.6	0.9
Ever highly irritable/argumentative for 2 days	1.8	2.2	6.2	0.2	1.6	-0.3	-2.5
Loud music exposure frequency	1.6	1.8	2.8	-0.2	-1.7	1.6	1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.6	1.2	-0.1	1.9	0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	-1.3	1.2	0.1	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.9	-1.4	0.3	0.0	0.0
Medication: Paracetamol	0.4	0.6	1.6	0.8	0.4	0.2	-1.3
Headache pain in last month	0.5	0.9	2.0	-0.2	0.7	1.0	-1.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.9	-1.4	0.2	-2.0	-0.4
Glaucoma (self-reported)	1.5	1.7	2.8	1.6	-1.7	-0.1	1.3
Gout (self-reported)	0.7	1.0	2.7	-1.6	0.9	-0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	0.1	1.1	0.7	-0.2
Medication: Amlodipine	0.7	1.0	3.1	1.8	0.3	0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.4	0.5	0.3	1.1
Birth weight	0.1	0.3	1.0	0.2	-0.4	0.2	-1.0
Chronic bronchitis/emphysema (mother)	1.7	1.9	7.2	-2.7	0.5	-0.4	-0.3
High blood pressure (siblings)	0.2	0.3	0.9	0.1	0.9	-0.4	-0.4
Forced vital capacity (FVC), Best measure	0.6	2.2	4.0	-1.1	-2.0	0.4	1.8
Body fat percentage	0.2	0.7	1.7	0.2	1.0	0.0	-1.3
Leg fat percentage (right)	0.2	0.8	2.0	0.7	0.6	-0.5	-1.4
Arm fat-free mass (right)	0.6	3.1	9.8	0.8	-1.2	3.1	0.6
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.5	-1.0	0.3	0.4
Comparative body size at age 10	0.1	0.2	0.6	0.5	-0.0	0.1	-0.8
Number of full brothers	0.4	0.5	0.9	0.9	0.6	0.7	-0.3
Worry too long after embarrassment	0.8	1.4	3.3	-0.9	-0.4	-1.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.1	0.1	1.8	-1.3	-1.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	-0.1	1.4	-0.4	0.8
Number of children fathered	1.0	1.2	2.8	1.7	-0.9	-1.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.4	1.0	0.7	-1.1
Age at first live birth	0.6	1.0	1.7	0.8	1.2	0.7	-1.3
Pulse wave peak to peak time	2.4	2.8	7.9	2.8	-1.6	-0.3	-0.8
Health satisfaction	1.5	1.9	5.4	0.3	2.3	1.0	-1.1
Shortness of breath walking on level ground	1.0	1.2	2.8	-0.9	0.2	1.7	1.0
Qualifications: College or University degree	0.1	0.4	0.8	-0.7	-0.1	0.6	0.9
Eye problems/disorders: None of the above	0.6	0.7	2.1	-0.5	0.6	-1.5	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.8	0.2	-0.1	-0.3
Emphysema/chronic bronchitis	0.5	0.6	0.9	0.5	0.9	-0.8	0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-1.1	0.4	0.5	1.3
Neck or shoulder pain in last month	1.3	1.8	3.6	-1.8	0.6	-1.9	-0.1
Medication: Blood pressure	1.0	1.7	4.8	1.4	0.1	2.2	0.2
Angina (self-reported)	0.9	1.2	2.8	1.7	0.3	-1.2	0.4
Migraine (self-reported)	1.2	1.4	2.2	1.5	-0.4	1.5	-1.1
Medication: Ibuprofen	0.3	0.4	1.4	0.5	-0.0	-0.0	-1.2
Medication: Allopurinol	0.7	1.0	1.5	-1.2	1.2	1.0	-0.1
Medication: Omeprazole	2.4	2.9	5.9	-0.6	1.7	-1.6	-2.4
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.5	0.6	-0.1	0.5
Mean time to correctly identify matches	2.0	3.7	8.6	0.8	-0.2	2.9	2.4
Heart disease (mother)	0.2	0.2	0.6	0.2	0.1	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	0.9	-0.3	-0.7	0.6
Whole body fat mass	0.1	0.5	0.8	0.6	0.4	0.9	-0.9
Leg fat mass (right)	0.2	0.7	1.5	0.8	0.6	0.5	-1.2
Arm predicted mass (right)	0.5	2.8	9.2	0.7	-1.0	3.0	0.5
Pulse rate, automated reading	1.2	4.0	5.4	-2.3	2.3	-0.6	-2.2
Alcohol intake frequency.	0.4	0.9	1.2	1.1	-1.0	-0.6	-1.1
Comparative height size at age 10	0.7	3.6	7.7	0.7	-1.0	2.3	2.8
Number of full sisters	1.7	2.1	4.9	-0.2	-0.3	-1.8	-2.2
Suffer from ‘nerves’	0.2	0.4	0.7	-0.5	-0.7	0.2	0.8
Overall health rating	0.5	1.1	2.1	0.7	0.6	-1.2	-1.4
Chest pain or discomfort	0.4	0.5	1.1	0.6	0.5	0.7	1.0
Had major operations	4.8	5.6	17.0	-0.4	4.1	-0.3	-2.3
Age at last live birth	0.1	0.1	0.5	0.7	0.0	-0.2	-0.3
Family relationship satisfaction	0.7	0.8	2.7	0.7	0.4	1.6	0.0
Leg pain on walking	0.3	0.3	1.1	-0.2	-0.5	0.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.0	0.5	1.6	-1.3	-2.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.5	-0.9	-0.0	-1.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	2.5	-1.2	-0.7	-1.6	0.3
Medication: Aspirin	1.0	1.3	5.0	2.2	-0.4	-0.1	-0.4
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	-0.4	-0.0	0.1
Knee pain experienced in last month	0.4	0.6	1.5	1.2	0.3	0.7	-0.7
Hypertension (Self-reported)	0.3	0.8	1.8	0.9	-0.3	0.6	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	3.6	-1.0	1.9	-1.2	-1.8
Illnesses of father: Heart disease	0.4	0.5	1.2	1.1	-0.4	0.8	0.1
Illnesses of siblings: Diabetes	1.5	1.9	6.5	2.6	-0.7	0.7	0.1
Smoking status: Previous	0.5	0.7	1.0	0.8	0.8	1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.7	-0.5	-0.7	-0.1	1.6
Whole body fat-free mass	0.8	4.3	11.5	1.4	-1.6	3.4	1.1
Leg fat-free mass (right)	0.6	3.3	10.4	1.2	-1.2	3.2	0.3
Arm fat percentage (left)	0.2	0.7	2.0	0.3	0.7	0.4	-1.4
Average weekly red wine intake	0.8	1.2	4.2	0.3	-0.6	0.5	2.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.9	-1.7	0.4	0.9	1.2
Mood swings	0.2	0.4	1.0	-0.6	-0.4	-1.0	-0.1
Loneliness, isolation	0.1	0.2	0.5	0.3	0.1	0.7	0.5
Long-standing illness, disability or infirmity	0.9	1.4	3.1	1.0	1.8	1.1	-0.6
Ever had bowel cancer screening	1.0	1.2	2.4	-1.5	0.5	-1.6	-0.3
Diabetes diagnosed by doctor	1.7	2.8	5.2	1.4	-0.7	1.9	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.0	-1.0	-1.1	0.0
Friendships satisfaction	0.2	0.3	0.6	0.3	-0.5	0.8	0.5
Qualifications: nursing, teaching	0.2	0.3	0.9	-0.4	0.0	1.0	0.6
Commuting to job workplace: Walk	0.6	0.7	2.5	0.1	-0.5	1.6	0.3
Eye problems/disorders: Cataract	0.3	0.4	1.2	-0.3	-0.4	1.1	0.3
Mouth/teeth dental problems: Mouth ulcers	2.6	4.2	5.5	-2.0	2.2	-1.7	-2.3
Medication for cholesterol	0.4	0.6	2.1	-1.4	0.3	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.5	-1.9	0.4	-2.1	-0.2
Back pain experienced in last month	1.0	1.5	5.4	-0.2	-0.1	-0.8	2.3
Mineral and other dietary supplements	0.4	0.5	1.7	-0.3	0.2	-1.3	0.5
Breast cancer (self-reported)	0.2	0.3	0.5	-0.3	-0.7	0.4	0.6
Asthma (self-reported)	0.3	0.6	2.2	-0.0	0.6	-0.2	1.5
Osteoporosis (self-reported)	1.4	1.7	3.7	-0.7	0.4	-1.9	-1.6
Osteoarthritis (self-reported)	2.0	2.6	8.8	0.2	1.0	0.7	-3.0
Medication: Aspirin	1.2	1.5	5.5	2.3	-0.6	-0.5	-0.3
Medication: Gliclazide	1.2	1.3	3.6	1.9	0.5	1.2	-0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.2	-1.1	-0.8	-1.1	1.0
Smoking status: Current	0.7	1.2	2.2	-1.5	0.3	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.5	-1.0	0.2	0.5
Whole body water mass	0.7	4.2	11.4	1.4	-1.5	3.4	1.0
Leg predicted mass (right)	0.7	3.5	10.9	1.2	-1.2	3.3	0.3
Arm fat mass (left)	0.2	0.7	2.1	0.6	-0.1	1.5	-0.6
Number of self-reported non-cancer illnesses	0.5	0.9	3.0	-0.3	1.7	0.6	0.2
Average weekly champagne plus white wine intake	0.3	0.3	0.8	0.4	0.9	0.3	0.6
Miserableness	0.4	0.7	2.5	-1.6	0.5	-0.3	-0.1
Guilty feelings	0.5	0.7	1.2	-0.7	0.8	-0.6	-1.1
Wears glasses or contact lenses	0.5	0.6	1.7	0.4	1.3	0.7	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.0	-0.3	-0.5	-0.6
Hearing aid user	1.1	1.2	2.8	1.7	0.8	1.2	-0.4
Mother’s age at death	0.2	0.2	0.3	0.6	-0.1	-0.6	0.5
Financial situation satisfaction	1.0	1.3	4.3	-2.1	0.4	-0.3	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.8	0.6	-0.4	0.2
Commuting to job workplace: Public transport	0.8	0.9	2.3	1.0	-1.5	0.5	0.4
Eye problems/disorders: Glaucoma	2.3	2.7	4.3	2.1	-2.0	0.4	1.5
Medication: Blood pressure	1.1	2.0	2.8	1.4	-1.7	0.9	1.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	1.0	-0.7	0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	-0.6	0.6	0.3	-1.0
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.2	0.4	-0.3	-1.0
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.3	0.7	0.2	-0.4
Medication: Paracetamol	0.6	0.9	2.3	0.9	0.4	-0.6	-1.5
Medication: Lisinopril	2.1	2.7	3.5	1.5	-1.9	1.7	1.6
Medication: Atorvastatin	0.6	0.8	1.2	-0.3	1.0	1.1	1.0
Illnesses of father: High blood pressure	0.7	0.9	1.4	0.0	1.0	1.1	-1.2
Alcohol drinker status: Never	2.2	2.6	9.1	3.0	-1.1	0.1	-0.2
Ever smoked	0.8	1.5	5.7	-0.2	2.4	0.3	-0.4
Basal metabolic rate	0.7	3.6	10.4	1.4	-1.3	3.2	0.7
Leg fat percentage (left)	0.3	1.2	3.1	0.3	1.2	-0.2	-1.8
Arm fat-free mass (left)	0.7	3.6	10.4	0.9	-1.4	3.2	1.1
Number of operations (self-reported)	1.5	2.2	6.5	0.3	2.6	0.1	-1.5
Average weekly beer plus cider intake	1.3	1.8	3.0	1.7	-1.7	-0.8	0.8
Irritability	0.2	0.3	0.9	0.5	-0.4	-0.9	-0.0
Risk taking	0.3	0.5	1.1	1.1	0.4	0.1	0.7
Ever had prostate specific antigen (PSA) test	1.5	1.7	6.3	-0.4	2.5	0.3	-0.5
Fractured/broken bones in last 5 years	0.4	0.6	0.9	1.0	-0.7	-0.1	0.9
Age started oral contraceptive pill	0.4	0.5	1.5	-0.5	0.5	1.2	-0.1
Diastolic blood pressure, automated reading	0.2	0.5	1.2	0.8	-1.1	-0.1	-0.1
Ever depressed for a whole week	0.3	0.3	0.8	0.5	-0.5	0.9	0.0
Unable to work because of sickness or disability	1.3	1.7	3.3	-1.3	0.5	-1.8	-1.3
Commuting to job workplace: Cycle	2.7	3.2	5.7	2.2	-1.2	-0.7	2.4
Myopia	1.7	2.5	3.3	1.5	-1.7	-1.3	1.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.1	-1.4	0.4	-1.0	-1.4
Cholesterol lowering medication	0.5	0.8	2.2	1.5	-0.2	-0.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	4.3	-0.9	1.5	-1.8	-2.1
Pain experienced in last month	0.2	0.3	0.7	-0.8	-0.6	0.2	0.4
Supplements: Calcium	0.6	0.7	1.6	-1.2	0.2	-0.2	-1.0
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-1.1	0.2	-1.1	1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	0.8	-0.6	0.4	1.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.4	-1.6	0.2	-0.5	-0.2
Heart disease (siblings)	1.3	1.6	5.5	-0.5	-0.7	0.2	2.3
Alcohol drinker status: Previous	0.7	0.8	2.1	-0.9	1.5	-0.3	-0.4
Pack years of smoking	0.1	0.2	0.4	0.2	-0.3	-0.4	-0.6
Impedance of whole body	0.6	2.9	10.1	-0.9	0.9	-3.2	0.0
Leg fat mass (left)	0.2	0.9	1.7	0.6	0.8	0.8	-1.3
Arm predicted mass (left)	0.7	3.5	10.5	0.8	-1.2	3.2	1.1