TWAS hub - WBP4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1500	0.0610	2.6e-03	0.001	NA	-0.004	NA	0.005	2.9e-01	NA	5.9e-01	NA	1.7e-01
2	GTEx	Lung	0.1045	0.0424	1.2e-03	0.085	NA	0.062	NA	0.072	4.6e-07	NA	1.5e-05	NA	3.6e-06
3	GTEx	Muscle Skeletal	0.3271	0.0566	1.1e-16	0.085	NA	0.227	NA	0.229	1.1e-08	NA	5.2e-22	NA	2.9e-22
4	GTEx	Nerve Tibial	0.0856	0.0383	3.9e-03	-0.002	NA	0.041	NA	0.018	4.3e-01	NA	7.1e-04	NA	1.7e-02
5	GTEx	Skin Sun Exposed Lower leg	0.1950	0.0570	3.6e-06	0.080	NA	0.085	NA	0.108	3.7e-07	NA	1.5e-07	NA	3.0e-09
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0510	0.0280	5.0e-03	0.019	0.020	0.019	NA	0.036	2.8e-02	2.5e-02	2.8e-02	NA	4.0e-03
7	TCGA	Brain Lower Grade Glioma	0.0446	0.0210	9.7e-05	0.017	0.043	0.040	NA	0.027	4.3e-03	1.2e-05	2.2e-05	NA	4.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Severe depression (siblings)	6.7	7.5	14.5	1.1	3.8	3.4	2.6	3.5	-0.0	2.4
Financial situation satisfaction	3.9	4.9	8.2	-2.3	-1.8	-2.7	-2.2	-1.5	-1.8	-2.9
Wears glasses or contact lenses	3.2	3.7	7.6	-2.8	-1.0	-1.7	-2.3	-1.0	-2.6	-1.1
HDL Cholesterol	2.8	4.7	7.3	-1.0	-2.6	-2.7	-2.2	-2.6	-1.6	-1.8
Age at First Birth	2.7	3.9	7.2	-0.2	-2.7	-2.4	-2.2	-2.6	-0.3	-1.6
Alzheimer’s Disease (in father)	2.6	2.8	6.9	-2.4	-1.2	-1.7	-1.0	-0.7	1.2	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	5.2	0.1	2.0	2.3	2.0	1.8	0.2	2.0
Commuting to job workplace: Cycle	2.5	3.0	7.7	1.9	1.0	1.6	1.8	1.0	2.8	1.3
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	4.9	-0.9	-2.2	-2.0	-2.2	-1.9	-0.9	-1.7
Leg pain on walking	2.3	2.9	4.2	-0.5	-2.0	-2.0	-1.6	-1.9	-2.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	9.5	-0.7	-2.6	-2.7	-1.7	-2.3	-0.6	-3.1
Medication: Metformin	2.2	3.1	6.6	2.6	1.2	1.6	2.1	1.3	2.1	0.9
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	6.0	-1.6	-1.3	-1.7	-2.0	-1.6	-2.5	-0.4
Family relationship satisfaction	2.2	2.7	11.2	-3.3	1.5	0.5	-0.3	1.9	-1.0	-0.3
HbA1C	2.1	2.4	5.6	-2.4	-1.3	-1.5	-1.5	-1.0	-0.8	-1.8
Ever had bowel cancer screening	1.9	2.2	6.2	-0.7	-1.7	-1.2	-1.0	-1.9	-2.5	0.2
Ulcerative Colitis	1.8	2.7	4.8	0.3	1.9	2.2	0.7	1.8	-1.2	2.2
Medication for hormone replacement therapy	1.8	2.0	4.3	-1.0	-1.8	-1.3	-2.1	-1.8	-0.5	-0.7
Diabetes (father)	1.8	2.2	4.5	0.3	2.1	1.6	1.6	2.0	-0.4	1.0
Leg fat-free mass (right)	1.8	9.8	16.7	-1.9	-4.0	-3.9	-2.2	-3.4	0.8	-4.1
Leg predicted mass (right)	1.8	9.4	16.4	-1.9	-3.9	-3.8	-2.1	-3.3	0.9	-4.1
Illnesses of father: High blood pressure	1.8	2.2	3.2	0.9	1.8	1.7	1.5	1.6	-1.1	1.7
Chronotype (morning person)	1.7	3.9	9.2	2.0	1.3	2.4	3.0	1.1	0.3	2.3
Medication: Atenolol	1.7	2.1	3.5	1.5	1.2	1.7	1.0	1.3	1.9	1.5
Worry too long after embarrassment	1.7	2.8	5.1	0.4	-1.5	-2.0	-2.1	-1.5	-2.3	-0.9
Heart disease (mother)	1.7	2.1	4.5	-0.5	-1.8	-1.5	-2.1	-1.7	0.1	-1.2
Comparative height size at age 10	1.7	9.5	16.1	-1.6	-4.0	-3.7	-3.0	-3.4	0.3	-3.7
Ulcerative Colitis (UC)	1.6	3.0	6.4	-0.3	1.9	2.5	1.1	1.8	-0.8	2.4
Supplements: Zinc	1.6	1.8	5.0	-0.3	2.0	1.7	0.0	2.2	-0.2	0.7
Impedance of leg (right)	1.6	7.6	12.0	2.7	3.2	3.5	2.2	2.8	-0.7	3.2
Leg fat-free mass (left)	1.6	8.3	16.7	-1.7	-3.6	-3.5	-1.9	-2.9	1.2	-4.1
Diabetes (self-reported)	1.6	2.4	7.5	2.7	1.1	1.6	1.3	1.0	1.4	1.1
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.8	-1.0	1.5	1.2	0.4	1.1	-2.0	2.0
Had major operations	1.6	1.9	10.7	1.0	-0.2	-0.2	-0.9	-0.3	-3.3	0.8
Osteoarthritis (self-reported)	1.6	2.1	4.1	-1.2	-1.4	-1.6	-2.0	-1.2	-1.2	-1.4
Commuting to job workplace: Public transport	1.6	2.0	5.1	2.3	1.1	0.9	1.3	1.1	1.9	0.4
Type 2 Diabetes (T2D) (2018)	1.5	2.8	4.8	2.2	1.4	1.6	2.1	1.2	1.3	1.5
Supplements: Glucosamine	1.5	1.9	4.5	0.0	-1.6	-1.7	-2.1	-1.3	-0.3	-1.3
Leg predicted mass (left)	1.5	8.1	16.4	-1.7	-3.6	-3.4	-1.8	-2.9	1.2	-4.1
Trunk fat-free mass	1.5	8.3	20.2	-1.1	-3.4	-3.5	-2.3	-2.5	1.1	-4.5
Falls in the last year	1.5	2.0	4.3	0.6	1.5	2.1	1.5	1.4	1.4	1.2
Pulse rate	1.5	2.6	13.8	3.7	-0.8	-1.1	-0.6	-1.0	-0.8	-0.8
Trunk predicted mass	1.5	8.4	20.1	-1.1	-3.4	-3.5	-2.3	-2.6	1.1	-4.5
Breastfed as a baby	1.5	1.8	2.9	-0.7	-1.7	-1.7	-1.6	-1.5	0.4	-1.3
Whole body fat-free mass	1.5	8.6	18.8	-1.5	-3.5	-3.6	-2.1	-2.8	1.1	-4.3
Medication: Gliclazide	1.5	1.7	3.3	0.6	1.3	1.5	1.8	1.3	0.9	1.1
Whole body water mass	1.5	8.6	18.0	-1.4	-3.6	-3.6	-2.2	-2.9	1.0	-4.2
Alcohol drinker status: Never	1.5	1.7	3.4	0.8	1.0	1.7	1.2	0.9	1.9	1.4
Angina	1.4	1.8	5.8	2.4	0.1	0.9	0.7	0.1	1.9	1.3
Average weekly fortified wine intake	1.4	1.6	9.9	-0.1	0.2	-0.4	-0.7	-0.1	-3.1	0.9
Sitting height	1.4	10.0	16.4	-0.2	-4.0	-3.9	-3.1	-3.4	-1.0	-4.0
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.0	-0.5	-1.5	-1.4	-1.7	-1.3	-0.6	-1.4
Angina (self-reported)	1.4	1.8	6.3	2.5	0.3	1.0	0.8	0.2	1.6	1.5
Pulse rate, automated reading	1.4	4.4	23.2	4.8	-0.2	-0.0	0.1	-0.8	-2.2	1.5
Basal metabolic rate	1.4	7.7	16.6	-1.4	-3.4	-3.5	-1.9	-2.7	1.0	-4.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	6.5	-0.0	1.1	0.7	0.0	0.8	-2.5	1.7
Impedance of leg (left)	1.3	6.4	12.2	2.7	2.6	2.9	1.7	2.0	-1.7	3.5
Father’s age at death	1.3	1.8	6.6	-2.6	1.3	1.0	0.6	1.3	-0.8	0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.4	0.3	1.7	1.6	0.7	1.4	-1.2	2.3
Mineral and other dietary supplements	1.3	1.7	3.7	0.8	1.5	1.6	1.9	1.3	-0.0	1.2
Fractured/broken bones in last 5 years	1.3	1.7	3.9	0.4	-1.2	-1.3	-1.7	-1.0	0.7	-2.0
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.7	1.7	-1.2	-0.7	-1.0	-1.4	1.9	-0.5
Pack years of smoking	1.3	1.8	5.7	0.4	2.0	1.6	-0.3	2.4	-0.0	0.5
Arm predicted mass (left)	1.3	6.6	15.0	-1.1	-3.1	-3.2	-1.7	-2.5	0.7	-3.9
Prostate Cancer	1.2	1.7	4.9	-1.2	-0.8	-0.8	-1.3	-1.4	-2.2	1.0
Blood Platelet Count	1.2	14.3	68.6	-3.8	2.4	0.1	-1.2	2.1	-8.3	2.4
Height	1.2	22.9	39.9	0.4	-6.2	-5.4	-4.6	-5.4	1.3	-6.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.2	-1.2	-1.1	-1.5	-1.4	-0.9	-0.6	-1.3
Heart attack	1.2	1.5	3.4	1.7	-1.1	-0.6	-0.8	-1.3	1.8	-0.4
Weight	1.2	5.7	12.1	-1.3	-2.9	-3.0	-1.3	-2.4	1.0	-3.5
Time employed in main current job	1.2	1.4	2.6	-0.8	1.3	1.4	1.3	1.6	1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	10.0	-0.8	-2.1	-2.3	-1.7	-1.6	1.1	-3.2
Diabetes diagnosed by doctor	1.2	1.9	3.6	1.9	1.1	1.5	1.5	0.9	1.4	1.2
Eye problems/disorders: Glaucoma	1.2	1.4	4.7	0.7	-1.5	-0.5	0.3	-1.5	2.2	-0.3
Ever smoked	1.2	2.1	11.2	0.5	0.2	0.2	-0.3	-0.1	-3.4	1.7
Arm fat-free mass (left)	1.2	6.0	14.5	-0.9	-2.9	-3.0	-1.7	-2.2	1.1	-3.8
Mouth/teeth dental problems	1.1	1.7	3.0	1.7	1.3	1.3	1.6	1.3	1.1	0.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	0.5	-2.0	-1.5	-0.3	-2.0	0.3	-1.1
Glaucoma (self-reported)	1.1	1.3	5.2	1.0	-0.7	0.4	1.3	-0.7	2.3	0.2
Arm fat-free mass (right)	1.1	5.9	12.9	-1.0	-3.0	-3.0	-1.8	-2.4	0.6	-3.6
Age at first live birth	1.1	1.9	3.2	-0.9	-1.8	-1.6	-1.2	-1.8	-0.3	-1.4
Illnesses of siblings: Diabetes	1.1	1.4	3.6	1.9	0.7	0.9	1.2	0.5	1.5	0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.8	0.4	1.4	1.5	0.7	1.2	-0.6	1.7
Ovarian Cancer	1.0	1.3	3.0	-0.2	-1.4	-1.2	-1.1	-1.2	0.2	-1.7
Respiratory disease	1.0	2.3	4.4	0.3	-1.4	-1.7	-2.1	-1.7	-1.8	-0.5
Lung FEV1/FVC ratio	1.0	5.2	11.9	-3.5	-1.9	-2.5	-0.5	-1.5	1.4	-3.2
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.8	-1.1	-0.8	-1.1	-1.3	-0.9	-1.9	-0.3
Medication: Co-codamol	1.0	1.1	2.9	-0.1	-1.7	-1.0	-0.9	-1.6	0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.2	-1.8	-0.4	-0.7	-0.8	-0.8	-1.6	0.3
Number of incorrect matches in round	1.0	1.6	4.2	0.1	-1.8	-1.6	-0.6	-2.0	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.7	-0.8	-2.0	-2.1	-2.3	-1.7	0.4	-2.4
Mouth/teeth dental problems: Dentures	1.0	1.7	3.7	-0.5	-1.9	-1.8	-0.4	-1.9	0.6	-0.9
Standing height	1.0	9.6	16.8	-0.4	-4.0	-3.6	-3.1	-3.4	-0.4	-4.1
Pulse wave reflection index	1.0	1.2	5.9	-2.4	-0.2	-0.1	-0.4	0.0	-1.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.3	0.5	1.2	1.3	1.5	1.0	-0.9	1.5
Arm predicted mass (right)	1.0	5.2	11.4	-1.1	-2.8	-2.9	-1.6	-2.2	0.6	-3.4
Miserableness	1.0	1.8	2.7	-0.2	-1.6	-1.6	-1.3	-1.6	-1.6	-0.4
Medication: Lisinopril	1.0	1.3	5.6	0.8	0.0	0.4	0.0	0.5	2.4	-1.5
Average weekly beer plus cider intake	1.0	1.5	3.3	0.5	0.9	1.3	1.8	0.9	1.8	0.6
Irritable Bowel Disease (IBD)	0.9	2.2	4.7	0.6	1.3	2.2	1.6	1.3	1.0	1.8
Breast Cancer	0.9	2.2	8.8	-1.1	-0.1	0.3	-0.2	-0.6	-3.0	2.1
Hypothyroidism (self reported)	0.9	2.0	3.9	2.0	-1.6	-0.9	-1.1	-1.9	-1.0	1.0
Nervous feelings	0.9	1.6	4.1	0.0	-1.3	-1.4	-2.0	-1.0	-0.1	-1.6
Hip circumference	0.9	3.8	7.3	-0.5	-2.6	-2.5	-0.6	-2.2	0.8	-2.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.1	-0.2	1.3	1.2	0.6	1.0	-0.9	1.5
Depression (self-reported)	0.9	1.1	3.7	-1.2	-0.8	-0.7	-0.3	-1.0	-1.9	0.2
Prospective memory result	0.9	1.1	1.9	1.4	0.9	1.0	1.2	0.8	-0.8	1.3
Peak expiratory flow (PEF)	0.9	2.0	3.9	-0.1	-1.5	-1.7	-1.7	-1.4	0.4	-2.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.0	1.3	-1.7	-1.2	-1.1	-2.0	-0.8	0.6
Forced vital capacity (FVC), Best measure	0.9	3.2	9.3	-0.4	-1.7	-1.9	-1.9	-1.2	1.1	-3.0
Long-standing illness, disability or infirmity	0.9	1.3	3.2	0.4	1.8	1.4	0.3	1.7	-0.6	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.0	-0.6	-1.4	-1.1	-0.3	-1.0	0.5	-1.3
Neuroticism (Nagel 2018)	0.8	1.8	4.8	0.7	-1.2	-1.6	-2.2	-0.9	-0.7	-1.3
Fasting Glucose	0.8	1.0	2.5	0.5	0.9	0.5	0.6	1.6	1.4	-0.8
Vitamin and mineral supplements	0.8	1.1	1.9	-0.8	-1.1	-1.4	-0.8	-1.1	-0.8	-1.0
Diabetes (mother)	0.8	1.0	3.8	2.0	-0.6	-0.1	1.1	-0.9	-0.0	0.9
Pack years adult smoking proportion	0.8	1.3	3.9	0.3	1.7	1.2	-0.6	2.0	-0.4	0.3
Current tobacco smoking	0.8	1.3	6.4	0.6	0.3	0.3	-1.4	0.2	-2.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.0	-0.5	-1.2	-1.5	-0.8	-1.5	-2.4	0.4
Financial difficulties in last 2 years	0.8	1.0	2.4	-1.6	-0.3	-1.1	-1.4	-0.1	-0.9	-0.9
Lung cancer (father)	0.8	0.9	3.0	-0.5	-0.7	-0.3	-0.9	-1.0	-1.7	1.0
Pulse wave Arterial Stiffness index	0.8	1.0	2.0	-0.7	-0.8	-1.4	-0.5	-0.6	-1.0	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.8	-1.9	0.9	0.5	0.5	1.0	0.1	-0.1
Osteoporosis (self-reported)	0.8	1.0	3.2	-1.8	0.9	0.8	0.7	1.1	0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.9	-0.6	-0.9	-1.0	-0.7	-0.6	2.2	-1.9
Mother’s age at death	0.8	0.9	2.7	-0.7	-1.6	-0.4	-0.8	-1.6	0.5	-0.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.8	0.1	-1.0	-1.0	-1.7	-0.9	-1.1	-0.4
Pain experienced in last month	0.8	1.3	3.0	1.5	0.4	0.5	1.7	0.3	1.6	0.9
Worry (Nagel 2018)	0.7	1.5	4.4	-0.0	-0.6	-1.1	-1.7	-0.2	1.2	-2.1
Blood Eosinophil Count	0.7	5.7	9.8	-0.2	3.0	2.3	0.6	2.8	-2.7	3.1
Townsend deprivation index at recruitment	0.7	1.0	2.2	-0.5	1.1	0.6	1.0	1.3	1.5	-0.3
Qualifications: CSEs or equivalent	0.7	1.0	1.7	-0.7	-1.0	-1.3	-0.9	-1.0	0.4	-1.3
Stomach or abdominal pain in last month	0.7	0.8	1.5	0.4	-0.9	-0.8	-1.2	-0.9	-1.2	-0.5
Had other major operations	0.7	0.8	4.3	-2.1	-0.2	-0.3	-0.8	0.0	0.2	-0.6
Forced vital capacity (FVC)	0.7	2.5	5.3	0.4	-1.9	-1.7	-2.3	-1.6	0.2	-1.8
Pain all over the body in last month	0.7	0.7	2.5	1.6	-0.6	-0.5	0.6	-0.9	0.0	0.8
Gout (self-reported)	0.7	0.9	2.5	-0.6	0.6	0.9	1.6	0.2	-0.5	1.5
Medication: Amlodipine	0.7	0.9	4.5	2.1	-0.0	0.2	0.5	-0.2	-0.4	1.2
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.8	-0.8	-0.5	-1.6	-0.8	-1.6	-0.2
Hearing aid user	0.7	0.7	3.0	-1.7	0.9	-0.3	-0.4	0.6	-0.9	-0.3
High cholesterol (Self-reported)	0.7	1.2	3.0	-0.3	-1.6	-1.3	-0.2	-1.7	0.7	-0.5
Medication: Atorvastatin	0.7	0.9	2.1	0.6	0.9	1.0	1.5	0.4	-0.4	1.4
Risk taking	0.7	1.0	2.8	1.7	1.0	1.0	1.0	0.8	-0.2	0.9
Depressed Affect (Nagel 2018)	0.6	1.2	1.7	1.3	-1.1	-1.2	-1.3	-1.0	-1.2	-0.4
Crohns Disease (2012)	0.6	1.0	2.9	1.7	0.4	1.1	0.4	0.6	1.6	0.4
Neuroticism (2016)	0.6	0.9	2.7	-0.6	-0.3	-0.8	-1.5	-0.0	0.6	-1.6
Rheumatoid Arthritis	0.6	0.9	2.0	0.7	1.0	0.9	0.9	0.8	-0.2	1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.1	0.7	-0.5	-0.3	0.6	-0.3	1.8	-0.7
Waist Hip Ratio (WHR)	0.6	2.5	4.5	0.4	1.8	1.9	2.1	1.7	0.9	1.4
Systolic Blood Pressure	0.6	3.2	20.1	4.5	0.2	0.7	0.1	0.5	1.2	0.2
Cardiovascular Disease	0.6	2.0	10.4	3.2	-0.2	0.6	1.1	-0.3	0.9	1.2
Neuroticism	0.6	1.5	3.0	0.9	-1.2	-1.5	-1.7	-0.8	0.6	-1.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.7	0.0	0.2	0.9	0.7	-0.2	-0.8	1.6
Qualifications: None of the above	0.6	1.3	4.6	1.5	-0.9	-0.4	0.2	-0.8	2.1	-0.6
Illnesses of siblings	0.6	0.8	1.4	-1.1	1.0	0.8	1.0	1.2	-0.5	0.3
Asthma	0.6	1.2	2.6	-0.3	-1.0	-1.4	-1.6	-1.2	-0.8	-0.7
Number of children fathered	0.6	0.7	3.9	-0.3	-0.7	0.0	0.2	-0.4	2.0	-0.1
Medication: Allopurinol	0.6	0.8	1.6	-1.2	0.6	0.6	1.2	0.2	-0.8	1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	-0.8	-0.7	-0.5	-0.6	-0.4	1.1	-1.4
Knee pain experienced in last month	0.6	0.9	2.5	-1.6	-0.4	-0.5	-1.5	-0.3	-0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.9	-0.4	0.3	-0.1	-0.5	0.1	-2.0	0.9
Mood swings	0.6	1.1	1.9	1.3	-1.4	-1.3	-0.8	-1.2	0.2	-0.8
Friendships satisfaction	0.6	0.8	1.9	-1.4	1.0	0.5	-0.2	1.4	0.2	-0.7
Smoking status: Current	0.6	1.0	5.1	0.1	-0.1	-0.1	-1.3	-0.1	-2.3	0.4
Supplements: Calcium	0.6	0.6	1.6	-0.8	0.9	0.9	0.2	1.3	0.7	0.1
Heart disease (siblings)	0.6	0.7	4.0	2.0	-0.4	-0.2	-0.4	-0.5	0.5	0.2
Impedance of whole body	0.6	3.2	7.1	1.3	1.8	2.2	1.0	1.3	-1.7	2.7
Depression (Nagel 2018)	0.5	0.8	1.8	0.4	-0.8	-0.4	-1.3	-0.8	-1.3	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	1.2	0.6	0.9	0.6	0.5	-0.1	1.0
Crohns Disease (2017)	0.5	1.0	4.7	1.0	-0.1	0.6	1.0	-0.1	2.2	0.3
Bipolar Disorder (2011)	0.5	0.5	1.2	-0.3	-0.8	-0.8	0.0	-0.8	0.3	-1.1
Coronary Artery Disease (CAD)	0.5	0.6	1.5	1.2	-0.9	-0.4	-0.1	-1.1	0.6	0.1
Smoking Status	0.5	1.2	6.2	-1.1	-0.1	-0.3	-0.8	0.1	-2.5	0.1
Hearing difficulty/problems: Yes	0.5	0.7	4.1	-2.0	0.1	-0.3	-0.5	0.2	-0.5	-0.4
Relative age of first facial hair	0.5	1.1	3.5	-0.4	-0.1	-0.3	-1.1	0.2	1.9	-1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	-0.1	0.8	1.2	0.6	0.9	0.6	0.9
Systolic blood pressure, automated reading	0.5	1.4	3.7	1.9	-1.2	-1.0	-1.0	-0.8	0.6	-1.3
Maternal smoking around birth	0.5	0.8	1.5	-0.2	1.2	0.9	-0.0	1.1	-1.1	0.7
Relative age voice broke	0.5	0.8	1.5	0.4	1.1	0.7	-0.0	1.1	-1.2	0.9
Age when periods started (menarche)	0.5	1.1	4.4	-1.2	0.6	0.6	0.5	0.8	2.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	-0.1	0.8	0.8	-0.4	0.8	-0.7	1.0
Medication: Levothyroxine sodium	0.5	0.9	2.3	0.7	-1.3	-0.6	-0.5	-1.5	-0.8	0.8
High blood pressure (mother)	0.5	0.7	1.6	0.7	-1.2	-0.9	0.1	-1.3	-0.8	0.2
Noisy workplace	0.5	0.7	1.4	1.1	-0.1	0.2	0.6	-0.6	-1.1	1.2
Arm fat mass (right)	0.5	2.0	3.4	-1.3	-1.9	-1.7	-0.2	-1.6	0.6	-1.8
Tense / ‘highly strung’	0.5	0.8	2.1	-0.1	0.4	-0.2	-1.3	0.7	1.0	-1.5
Birth weight of first child	0.5	0.9	2.1	-0.4	0.9	1.3	0.8	0.6	-0.7	1.5
High blood pressure (siblings)	0.5	0.7	1.0	0.8	-1.0	-0.8	-1.0	-0.9	0.1	-0.7
Pulse wave peak to peak time	0.5	0.6	1.8	0.5	0.4	1.1	0.1	0.3	1.3	0.9
Medication: Omeprazole	0.5	0.6	1.3	-0.6	0.7	0.7	0.3	0.6	-1.1	1.1
Alcohol intake frequency.	0.5	1.1	3.9	1.2	0.4	0.9	0.2	0.5	2.0	0.9
Suffer from ‘nerves’	0.5	0.7	2.4	-1.0	-0.6	-0.7	-1.0	-0.3	-0.1	-1.5
Average weekly red wine intake	0.5	0.8	1.4	-1.0	-1.2	-1.0	-0.0	-1.0	-0.5	-0.8
Medication for cholesterol	0.5	0.7	1.4	-0.5	0.9	0.5	1.2	1.0	-0.9	0.6
Medication: Aspirin	0.5	0.6	1.0	0.7	0.8	0.9	0.3	0.7	1.0	0.7
Illnesses of father: None of the above (group 1)	0.5	0.7	1.9	0.8	-1.1	-0.3	-0.2	-1.0	1.4	-0.3
Arm fat mass (left)	0.5	2.1	3.5	-1.3	-1.9	-1.7	-0.2	-1.5	0.7	-1.8
Medication: Blood pressure	0.5	0.9	4.7	0.9	-0.0	-0.1	-0.4	0.2	2.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	-0.9	-0.7	-0.9	-1.1	-0.7	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	3.0	-0.5	-0.4	-0.5	-0.1	-0.6	-1.7	0.5
Myopia	0.5	0.7	1.0	0.4	0.6	1.0	0.9	0.5	1.0	0.9
Alcohol drinker status: Previous	0.5	0.6	3.2	1.8	0.2	0.3	-0.5	0.2	0.2	0.6
Major Depression (MDD)	0.4	0.5	2.2	0.1	-0.4	-0.1	-0.2	-0.2	1.5	-0.9
LDL Cholesterol	0.4	0.6	1.2	1.1	-1.0	-0.8	-0.4	-1.1	-0.2	-0.3
Lupus	0.4	0.6	2.0	-0.8	-0.5	-0.4	-0.3	-0.3	1.4	-0.8
Schizophrenia (2014)	0.4	0.8	1.4	0.9	0.9	0.8	0.5	1.1	1.2	-0.7
Triglycerides	0.4	0.6	1.7	1.3	-0.0	0.4	1.2	-0.1	1.0	0.4
Heel T-Score	0.4	3.0	4.9	-2.2	-1.5	-1.9	-2.1	-1.6	-1.9	-0.0
Tanning	0.4	5.3	7.9	-1.6	-2.4	-2.6	-2.8	-2.5	-2.6	-0.7
Average weekly spirits intake	0.4	0.5	2.2	0.4	0.6	-0.0	-0.2	0.7	-1.5	-0.3
Taking other prescription medications	0.4	0.6	1.5	0.4	-0.6	-0.8	-0.6	-0.9	-1.2	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.6	1.3	0.8	0.5	0.7	0.8	-0.3	0.1
Body mass index (BMI)	0.4	1.5	3.0	-1.4	-1.2	-1.4	0.0	-0.9	1.1	-1.7
Trunk fat mass	0.4	1.7	3.1	-1.1	-1.7	-1.7	-0.2	-1.6	-0.0	-1.6
Waist circumference	0.4	1.5	3.3	-0.3	-1.5	-1.6	0.2	-1.3	0.9	-1.8
Past tobacco smoking	0.4	0.7	3.5	0.7	-0.1	-0.1	0.2	0.0	1.9	-1.1
Medication: Ramipril	0.4	0.5	1.0	1.0	0.2	0.4	0.8	0.2	1.0	0.7
Neuroticism score	0.4	0.8	1.9	0.2	-0.8	-1.1	-1.4	-0.4	0.0	-1.4
Alcohol intake versus 10 years previously	0.4	0.6	1.4	1.2	-0.7	-0.8	-0.5	-0.5	1.0	-0.7
Happiness	0.4	0.5	2.5	-1.6	0.2	-0.0	-0.8	0.2	-0.6	0.1
Exposure to tobacco smoke at home	0.4	0.5	1.4	0.9	-0.4	-0.3	0.3	-0.2	1.2	-0.9
Loud music exposure frequency	0.4	0.5	1.2	-0.4	0.8	0.6	1.1	0.8	0.4	-0.2
Health satisfaction	0.4	0.5	2.7	-0.1	-0.1	-0.4	-0.6	-0.2	-1.6	0.4
Shortness of breath walking on level ground	0.4	0.5	1.9	-0.0	0.3	-0.4	-1.4	0.4	-0.9	-0.5
Migraine (self-reported)	0.4	0.5	1.7	0.5	0.7	0.8	1.3	0.8	0.4	0.1
Overall health rating	0.4	0.8	2.2	1.4	0.4	1.1	0.1	0.3	0.2	1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.9	-0.9	-0.3	-0.7	-0.5	-0.5	-0.8
Loneliness, isolation	0.4	0.5	1.4	-0.7	0.4	-0.1	-1.2	0.8	0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	0.8	-0.4	-0.3	-1.2	-0.2	-0.9	-0.3
Asthma (self-reported)	0.4	0.9	2.2	-0.7	-0.7	-1.1	-1.5	-0.8	-0.7	-0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.0	0.6	-0.7	-1.0	-0.8	-0.9	-0.5	-0.5
Number of operations (self-reported)	0.4	0.6	3.2	-0.4	-0.2	-0.4	-0.5	-0.0	-1.8	-0.3
Ever depressed for a whole week	0.4	0.4	1.7	-1.3	0.6	0.7	0.2	0.7	0.3	0.1
Primary Biliary Cirrhosis	0.3	0.5	3.0	1.7	0.1	0.5	-0.0	-0.3	-0.1	0.4
Blood Red Count	0.3	3.0	9.0	0.9	-0.6	-1.4	-3.0	-1.2	-2.7	0.6
BMI	0.3	1.7	3.8	-0.5	-1.5	-1.9	0.1	-1.4	0.8	-1.6
Fed-up feelings	0.3	0.6	3.6	1.9	0.1	0.1	0.4	0.2	-0.4	0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.3	-0.5	-0.3	-0.6	-0.7	-1.0	0.4
Alcohol usually taken with meals	0.3	0.5	2.2	0.2	-0.4	-0.6	-0.5	-0.6	-1.5	0.5
Hearing difficulty/problems with background noise	0.3	0.6	1.6	-1.3	0.7	0.0	-0.1	0.8	-1.1	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.8	-0.3	-0.2	-1.1	-0.3	-0.9	0.1
Impedance of arm (right)	0.3	1.5	3.3	0.5	1.2	1.7	0.7	1.0	-1.1	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.7	-0.3	-0.3	-0.6	-0.4	-1.2	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.2	-0.8	-0.5	-0.4	-0.7	0.8	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	1.1	-0.6	-0.6	-0.0	-0.7	-1.1	-0.1
Medication: Ibuprofen	0.3	0.4	1.1	0.2	-0.6	-0.6	-0.6	-0.6	-1.0	-0.5
Whole body fat mass	0.3	1.4	2.6	-1.1	-1.5	-1.5	0.0	-1.3	0.2	-1.6
Age at last live birth	0.3	0.4	1.3	-1.1	-0.4	-0.6	-0.7	-0.3	-0.0	-0.8
Medication: Aspirin	0.3	0.5	0.7	0.8	0.7	0.7	0.4	0.6	0.8	0.6
Hypertension (Self-reported)	0.3	0.7	3.4	1.9	0.1	0.3	0.6	0.2	1.0	0.1
Illnesses of father: Heart disease	0.3	0.4	0.9	0.2	-0.8	-0.5	-0.9	-0.9	-0.1	0.1
Smoking status: Previous	0.3	0.4	1.7	-1.3	0.1	0.2	-0.0	0.0	-0.8	0.6
Qualifications: nursing, teaching	0.3	0.4	1.6	-0.1	0.5	0.7	0.7	0.4	0.3	1.3
Breast cancer (self-reported)	0.3	0.4	1.1	-1.1	0.7	0.3	0.0	0.9	-0.1	-0.4
Ever taken oral contraceptive pill	0.3	0.4	1.2	1.1	-0.3	-0.3	0.3	-0.2	-1.0	0.1
Medication: Paracetamol	0.3	0.5	1.4	0.4	0.6	1.0	0.1	0.7	0.4	1.2
Diastolic blood pressure, automated reading	0.3	0.8	5.3	2.3	-0.1	0.3	-0.2	0.1	0.3	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.8	-1.7	-0.2	-0.3	-0.6	-0.4	-1.3	0.1
Bipolar Disorder (2018)	0.2	0.3	1.0	0.1	0.6	0.4	1.0	0.7	0.4	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	1.0	0.9	0.5	0.5	1.0	0.6	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	0.7	-0.9	-0.8	-0.1	-0.9	1.1	-0.7
Schizophrenia (2018)	0.2	0.4	1.3	1.1	0.7	0.3	-0.1	0.8	0.5	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.2	0.7	0.7	-0.6	0.9	0.2	0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	1.2	0.1	-0.2	-0.5	-0.2	-0.0	0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.3	1.1	-0.2	0.4	1.1	-0.2	1.0	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.5	-0.2	-0.8	-0.5	-0.2	-0.8	-0.4
Number of treatments/medications taken	0.2	0.4	2.2	1.5	0.2	0.4	0.3	0.1	0.2	0.7
Sensitivity / hurt feelings	0.2	0.3	1.5	-0.3	-0.1	-0.4	-0.3	0.0	-1.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.1	0.7	0.5	0.2	0.6	-0.3	0.0
Trunk fat percentage	0.2	0.6	1.2	-1.1	-1.0	-0.8	0.4	-1.0	-0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.3	0.3	0.6	-0.8	0.4	-0.6	0.6
Had menopause	0.2	0.3	0.7	-0.9	-0.5	-0.5	-0.2	-0.6	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.3	0.6	0.7	0.2	0.6	0.1	0.1
Allergy	0.2	0.5	1.0	-0.3	0.7	0.8	1.0	1.0	0.3	-0.2
Medication: Simvastatin	0.2	0.2	1.0	0.2	-0.3	-0.3	-0.3	-0.3	1.0	-0.5
Worrier / anxious feelings	0.2	0.3	1.2	-0.2	-0.2	0.0	-0.5	0.3	1.1	-0.9
Number of live births	0.2	0.3	1.1	-1.0	0.2	0.5	-0.4	0.4	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.3	-0.3	-0.5	-0.6	-0.2	-0.9	-0.6
Medication: Cholesterol lowering	0.2	0.2	0.6	0.3	-0.4	-0.0	0.4	-0.7	-0.4	0.8
Medication: Lansoprazole	0.2	0.2	0.8	0.9	-0.1	0.0	-0.2	-0.0	0.7	0.1
Illnesses of mother	0.2	0.2	0.5	0.7	0.6	0.3	-0.4	0.5	0.0	0.0
Impedance of arm (left)	0.2	1.1	3.2	0.4	0.9	1.4	0.5	0.6	-1.1	1.8
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.4	0.5	0.4	0.6	0.4	-0.2	0.7
Headache pain in last month	0.2	0.4	0.9	-0.9	0.6	1.0	-0.0	0.6	-0.3	0.7
Birth weight	0.2	0.4	1.1	-1.1	-0.6	-0.8	-0.4	-0.7	-0.6	-0.0
Comparative body size at age 10	0.2	0.7	2.3	-1.5	0.2	-0.4	-1.1	0.6	-0.3	-0.7
Qualifications: College or University degree	0.2	0.7	1.4	0.3	1.2	1.0	0.4	1.2	-0.1	0.8
Eye problems/disorders: None of the above	0.2	0.3	0.7	-0.1	0.7	0.4	0.4	0.9	-0.5	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.8	0.6	-0.3	-0.2	-0.0	-0.6	-0.3	0.9
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.2	0.6	0.7	-0.0	0.7	0.5	0.3
Mean time to correctly identify matches	0.2	0.4	1.7	-0.2	-0.3	-0.3	0.7	-0.2	1.3	-0.1
Chest pain or discomfort	0.2	0.3	0.7	0.3	-0.7	-0.7	-0.2	-0.6	0.3	-0.8
Supplements: Vitamin C	0.2	0.2	0.5	0.2	-0.6	-0.6	-0.7	-0.7	0.1	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.1	0.1	0.3	0.1	-0.1	-0.8	0.7
Arm fat percentage (left)	0.2	0.6	1.6	-1.3	-0.8	-0.9	0.5	-0.8	0.2	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.6	-0.2	-0.2	0.4	-0.2	0.8	0.4
Back pain experienced in last month	0.2	0.3	0.7	0.5	0.7	0.8	-0.5	0.9	-0.3	-0.1
Guilty feelings	0.2	0.3	1.0	-1.0	-0.0	-0.4	-0.5	0.2	-0.6	-0.3
Irritability	0.2	0.3	1.1	0.4	0.2	-0.1	-0.5	0.3	-1.1	-0.2
Age started oral contraceptive pill	0.2	0.2	0.4	-0.3	-0.5	-0.3	0.4	-0.7	-0.4	0.5
Reaction Time	0.1	0.2	0.7	0.4	-0.1	-0.1	0.7	-0.1	0.8	0.2
Blood White Count	0.1	0.5	1.0	0.9	-0.1	-0.7	0.2	0.3	-0.9	-1.0
Allergy or Eczema	0.1	0.3	0.8	0.4	-0.6	-0.5	-0.7	-0.9	-0.0	0.3
Hair Pigment	0.1	2.5	11.3	-3.4	0.5	-0.6	-1.0	1.1	-0.1	-1.8
Hand grip strength (left)	0.1	0.4	1.3	-0.6	0.6	0.3	-1.1	0.7	-0.1	-0.5
Hand grip strength (right)	0.1	0.2	0.5	0.5	0.6	0.5	-0.7	0.5	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.1	-0.8	-0.7	0.1	-0.8	-0.5	0.1
High blood pressure	0.1	0.4	1.2	1.1	0.1	0.2	0.4	0.3	1.0	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.6	-0.4	-0.4	-0.7	-0.5	0.4	-0.1
Multivitamins +/- minerals	0.1	0.2	0.4	-0.0	0.4	0.5	-0.3	0.5	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.5	0.1	0.0	-0.6	0.1	-0.8	-0.0
Fluid intelligence score	0.1	0.1	0.5	-0.1	-0.7	-0.2	-0.3	-0.6	-0.1	0.2
Arm fat percentage (right)	0.1	0.5	1.6	-1.3	-0.6	-0.7	0.7	-0.5	0.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.5	0.0	0.0	0.2	0.2	-0.1	-0.4	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.5	-0.0	-0.3	0.3	-0.1	-0.3	0.7	0.2
Length of working week for main job	0.1	0.1	0.4	0.5	-0.3	0.4	-0.1	-0.3	0.6	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.5	-0.1	-0.7	0.5	-0.1	-0.2	-0.9
Medication: Paracetamol	0.1	0.2	0.5	-0.2	-0.5	0.0	-0.7	-0.4	0.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.4	-0.2	-0.5	-0.4	-0.1	-0.7	-0.5
Body fat percentage	0.1	0.4	0.8	-0.9	-0.6	-0.7	0.7	-0.7	-0.1	-0.4
Leg fat percentage (right)	0.1	0.4	1.7	0.0	0.4	0.1	1.3	0.5	0.8	-0.3
Number of full brothers	0.1	0.1	0.3	-0.5	0.4	0.0	0.3	0.2	-0.3	0.3
Medication for pain relief, constipation, heartburn	0.1	0.3	0.7	-0.5	-0.1	-0.6	-0.5	-0.2	-0.4	-0.8
Medication: Blood pressure	0.1	0.1	0.3	0.5	0.1	0.3	0.5	0.2	0.3	0.3
Leg fat mass (right)	0.1	0.5	1.3	-0.4	-0.6	-0.8	0.7	-0.4	0.6	-1.1
Number of full sisters	0.1	0.2	0.9	0.2	0.1	0.3	0.2	-0.2	-0.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.1	-0.1	0.1	0.2	-0.3	-0.4	0.4
Commuting to job workplace: Walk	0.1	0.1	0.4	0.2	0.2	0.4	0.4	0.0	0.6	0.5
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.2	-0.3	-0.3	0.0	-0.5	-0.4	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.0	0.4	0.1	-0.2	0.4	-0.3	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	0.4	-0.0	-0.4	0.4	-0.2	-0.1
Leg fat percentage (left)	0.1	0.2	1.3	-0.0	0.0	-0.2	1.1	-0.0	0.2	-0.0
Unable to work because of sickness or disability	0.1	0.2	0.5	0.1	-0.6	-0.2	-0.2	-0.7	0.4	0.3
Cholesterol lowering medication	0.1	0.2	0.8	0.5	-0.0	-0.3	-0.5	-0.1	0.9	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.4	0.2	0.6	0.4	0.2	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.4	0.3	0.3	0.5	0.2	-0.0	0.6
Leg fat mass (left)	0.1	0.6	1.1	-0.5	-0.9	-1.0	0.5	-0.7	0.2	-1.0
Mean Putamen Volume	0.0	0.1	0.1	0.1	0.2	0.1	-0.2	0.4	0.2	-0.3
Lung FVC	0.0	0.1	0.7	0.3	0.1	-0.0	-0.8	0.2	0.1	-0.5
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.4	-0.0	-0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.1	0.2	-0.0	-0.2	0.2	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.1	-0.3	-0.2	0.0	-0.3	-0.2	0.2

Hub : Genes

WBP4

Models

Trait associations