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chr14:64,156,218-66,906,467

Best TWAS P=4.57e-31 · Best GWAS P=8.49e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	MAX	0.15	0.16	lasso	2	0.16	1.2e-18	11.31	-11.6	4.6e-31	-0.55	1.00	0.00	TRUE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB15	0.04	0.01	enet	5	0.03	1.9e-04	11.94	10.9	8.9e-28	0.82	0.00	0.97	TRUE
15	GTEx	Pituitary	RAB15	0.32	0.03	enet	16	0.10	1.9e-03	10.53	9.6	8.7e-22	0.63	0.16	0.44	TRUE
21	YFS	Blood	FNTB	0.43	0.40	enet	18	0.42	1.1e-151	-7.12	-8.6	1.3e-17	0.16	1.00	0.00	TRUE
19	GTEx	Thyroid	RAB15	0.26	0.04	enet	52	0.08	1.5e-06	6.35	7.7	1.8e-14	0.41	0.90	0.08	TRUE
8	GTEx	Breast Mammary Tissue (Female)	RP11-840I19.5	0.06	-0.01	lasso	1	0.08	2.8e-03	-7.39	7.4	1.5e-13	0.15	0.04	0.06	TRUE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB15	0.04	0.00	blup	49	0.01	6.9e-02	8.34	7.4	1.8e-13	0.51	0.11	0.11	TRUE
10	GTEx	Colon Transverse	MTHFD1	0.20	0.01	enet	49	0.02	6.2e-02	1.63	-7.0	3.0e-12	-0.20	0.14	0.37	TRUE
18	GTEx	Testis	PPP1R36	0.29	0.25	enet	17	0.28	1.1e-12	-3.98	6.9	5.6e-12	0.36	1.00	0.00	TRUE
11	GTEx	Esophagus Muscularis	RAB15	0.35	0.06	enet	23	0.17	1.2e-10	6.35	6.1	1.0e-09	0.56	0.81	0.19	TRUE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	FUT8	0.04	0.02	lasso	4	0.02	3.6e-03	-5.81	5.7	1.6e-08	0.03	0.13	0.55	TRUE
4	GTEx	Adipose Subcutaneous	RAB15	0.48	0.07	enet	82	0.18	5.7e-15	0.59	5.6	2.5e-08	0.35	1.00	0.00	TRUE
14	GTEx	Nerve Tibial	RAB15	0.35	0.15	enet	68	0.18	4.7e-13	8.34	10.1	5.1e-24	0.43	1.00	0.00	FALSE
13	GTEx	Muscle Skeletal	FNTB	0.05	0.02	lasso	6	0.01	5.8e-02	9.78	-9.6	9.2e-22	-0.53	0.26	0.43	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNTB	0.06	0.02	blup	106	0.04	3.7e-05	2.22	-9.4	6.6e-21	-0.51	0.16	0.38	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB15	0.14	0.07	enet	15	0.09	5.5e-10	8.34	8.7	2.9e-18	0.56	0.65	0.35	FALSE
22	YFS	Blood	MAX	0.04	0.02	lasso	4	0.02	2.8e-06	7.64	-8.3	8.3e-17	-0.66	0.69	0.26	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FUT8	0.06	0.02	blup	516	0.03	1.2e-04	-4.45	8.1	8.4e-16	0.27	0.48	0.02	FALSE
25	The Cancer Genome Atlas	Esophageal Carcinoma	FNTB	0.09	0.05	lasso	3	0.04	2.6e-02	9.04	-7.8	6.3e-15	-0.61	0.06	0.22	FALSE
9	GTEx	Cells Transformed fibroblasts	RAB15	0.64	0.08	enet	41	0.33	1.3e-25	6.35	7.6	2.8e-14	0.46	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FNTB	0.10	0.03	blup	107	0.07	7.9e-07	1.86	-7.4	1.4e-13	-0.36	0.85	0.02	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB15	0.04	0.05	blup	49	0.06	2.5e-07	2.64	7.0	2.2e-12	0.62	0.49	0.48	FALSE
7	GTEx	Brain Cerebellum	ZBTB25	0.23	0.12	lasso	4	0.14	5.7e-05	-7.17	6.9	4.5e-12	0.07	0.24	0.05	FALSE
5	GTEx	Artery Aorta	FUT8	0.13	0.01	enet	24	0.00	2.5e-01	-4.45	6.9	6.9e-12	0.22	0.26	0.04	FALSE
20	METSIM	Adipose	RAB15	0.10	0.04	enet	22	0.08	3.8e-12	8.49	6.8	7.1e-12	0.56	1.00	0.00	FALSE
17	GTEx	Testis	RAB15	0.23	0.16	lasso	5	0.13	2.8e-06	6.35	6.8	1.5e-11	0.59	0.16	0.78	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB15	0.02	0.01	blup	49	0.02	6.7e-05	2.64	6.6	3.8e-11	0.57	0.38	0.34	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB15	0.03	0.00	blup	49	0.01	1.8e-02	8.20	6.2	5.9e-10	0.59	0.05	0.64	FALSE
6	GTEx	Artery Aorta	SPTB	0.13	0.00	enet	11	0.01	9.0e-02	4.99	5.8	7.6e-09	0.23	0.08	0.05	FALSE
12	GTEx	Liver	CHURC1	0.27	0.19	enet	31	0.17	2.1e-05	1.80	-5.8	7.9e-09	-0.36	0.57	0.04	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB15	0.11	0.01	enet	12	0.06	1.1e-04	2.85	5.7	1.0e-08	0.51	0.02	0.85	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SPTB	0.06	0.05	bslmm	528	0.05	9.5e-07	2.86	-5.7	1.3e-08	-0.30	0.83	0.08	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	FNTB	0.05	0.04	blup	107	0.03	6.5e-03	1.75	-5.3	9.1e-08	-0.51	0.22	0.17	FALSE
16	GTEx	Spleen	FUT8	0.17	0.03	lasso	3	0.02	9.9e-02	4.40	5.3	1.4e-07	0.02	0.16	0.05	FALSE