TWAS hub - PPP1R36

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.143	0.043	1.9e-05	0.044	NA	0.027	NA	0.021	3.2e-04	NA	4.0e-03	NA	9.2e-03
2	GTEx	Liver	0.509	0.090	9.2e-06	0.077	NA	-0.010	NA	0.155	3.6e-03	NA	8.8e-01	NA	4.4e-05
3	GTEx	Testis	0.289	0.065	9.4e-08	0.251	NA	0.276	NA	0.263	1.7e-11	NA	1.1e-12	NA	4.8e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Diabetes (father)	3.6	4.4	12.9	-0.3	0.6	-3.6
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	9.7	-0.3	3.1	1.7
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	6.5	-1.7	2.6	1.3
Mouth/teeth dental problems: Dentures	2.7	4.5	11.0	3.3	-1.5	-0.6
Chronic bronchitis/emphysema (mother)	2.7	3.2	7.9	2.8	1.3	-0.2
Wears glasses or contact lenses	2.7	3.1	8.7	3.0	0.6	0.6
Verbal and Numeric Reasoning (VNR)	2.4	5.6	8.5	2.9	-1.5	2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	11.9	-3.5	-0.6	-1.6
Mouth/teeth dental problems	2.3	3.6	6.0	-2.5	-1.3	-1.7
Overall health rating	2.3	4.8	8.0	-2.0	1.5	2.8
Had major operations	2.3	2.7	7.1	-0.0	2.7	-1.0
Pack years of smoking	2.3	3.4	9.0	3.0	-0.0	-1.2
Height	2.2	42.6	102.0	-4.4	-2.5	-10.1
Family relationship satisfaction	2.2	2.7	6.1	2.5	-0.9	1.2
Friendships satisfaction	2.2	2.8	4.2	2.1	-1.8	-0.8
Had other major operations	2.1	2.5	7.3	0.5	-2.7	0.0
Allergy	2.1	4.8	13.3	-3.6	0.8	-0.7
Reaction Time	2.0	3.8	8.0	-1.0	2.8	1.6
Pack years adult smoking proportion	2.0	3.0	8.4	2.9	0.3	-0.7
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	7.4	2.7	0.5	0.6
Standing height	2.0	19.9	40.9	-4.1	-1.5	-6.4
Unable to work because of sickness or disability	2.0	2.6	4.2	-2.1	1.3	1.3
Medication: Lansoprazole	1.9	2.1	5.5	2.4	-0.7	0.6
Wheeze or whistling in the chest in last year	1.9	3.3	5.9	2.4	-0.5	1.9
Comparative height size at age 10	1.9	10.7	20.8	-3.2	-1.1	-4.6
Average weekly red wine intake	1.9	2.8	7.7	2.8	-0.7	-0.4
Hand grip strength (right)	1.8	4.8	14.1	0.0	-0.6	-3.7
Medication: Ibuprofen	1.8	2.2	4.7	2.2	0.5	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.6	-1.9	-1.2	-0.8
HbA1C	1.7	1.9	3.5	1.9	1.2	-0.9
Blood Platelet Count	1.7	19.3	47.5	3.2	-0.0	6.9
Respiratory disease	1.7	3.9	10.9	3.3	-0.4	0.7
Medication: Co-codamol	1.7	2.0	3.3	1.8	-1.5	-0.6
Age when periods started (menarche)	1.7	4.2	7.9	0.6	2.1	2.8
Hair/balding pattern: Pattern 2	1.7	2.1	3.5	-1.9	0.8	1.5
Supplements: Calcium	1.7	1.8	4.9	-0.1	2.2	-0.8
Schizophrenia (2014)	1.6	3.6	9.2	3.0	-0.4	1.2
Medication: Levothyroxine sodium	1.6	2.7	6.2	-2.5	-0.9	-1.0
Trunk fat-free mass	1.6	8.9	15.6	-3.2	-0.9	-4.0
Father’s age at death	1.6	2.2	5.7	2.4	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.8	2.2	0.4	-1.1
Pulse wave Arterial Stiffness index	1.6	1.9	5.4	0.4	-0.5	-2.3
Trunk predicted mass	1.6	8.9	15.6	-3.2	-0.8	-4.0
Illnesses of father: High blood pressure	1.6	1.9	2.3	-1.3	1.5	-1.4
Blood Red Count	1.5	14.2	38.4	-1.5	1.4	-6.2
Chronotype (morning person)	1.5	3.6	7.4	-2.7	1.7	0.7
Hand grip strength (left)	1.5	4.0	11.5	0.4	-0.6	-3.4
Taking other prescription medications	1.5	2.4	4.5	0.5	1.5	-2.1
Asthma	1.5	3.0	8.8	3.0	0.5	0.2
Leg fat percentage (right)	1.5	5.3	13.8	-1.3	0.7	3.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.7	-1.1	1.6	1.2
Illnesses of father: Heart disease	1.5	2.1	4.2	-0.0	1.4	2.1
Illnesses of siblings: Diabetes	1.5	1.9	2.5	-1.6	-0.9	1.6
Qualifications: nursing, teaching	1.5	2.4	5.1	2.3	0.6	1.3
Heart disease (siblings)	1.5	1.8	5.3	-0.2	-2.3	0.3
Alzheimer’s Disease (including proxy)	1.4	2.0	5.3	2.3	0.8	0.3
Ever had hysterectomy (womb removed)	1.4	1.6	3.9	2.0	-0.1	1.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.7	0.2	-1.6	1.3
Serious illness, injury or assault to yourself	1.4	1.8	4.5	-2.1	0.3	0.9
Qualifications: None of the above	1.4	3.1	3.8	-1.5	-1.8	-2.0
Arm fat percentage (right)	1.4	5.6	16.2	-0.6	0.5	4.0
Medication: Seretide 50 evohaler	1.4	1.6	3.2	-1.8	0.2	1.2
Mean time to correctly identify matches	1.4	2.6	4.3	-0.5	2.1	1.8
Asthma (self-reported)	1.4	2.9	8.2	2.9	0.5	0.5
Leg fat percentage (left)	1.4	5.2	14.0	-1.1	0.7	3.7
Alcohol drinker status: Previous	1.4	1.6	3.2	1.8	-1.1	0.4
Schizophrenia (2018)	1.3	2.7	5.1	2.3	-0.5	1.7
Heel T-Score	1.3	10.4	30.7	5.5	-0.6	0.3
Allergy or Eczema	1.3	3.3	7.2	2.7	-0.5	1.6
Falls in the last year	1.3	1.8	4.7	0.5	-0.5	2.2
Pulse wave reflection index	1.3	1.6	3.8	0.8	0.6	-1.9
Body fat percentage	1.3	5.3	14.8	-1.0	0.3	3.8
Pulse wave peak to peak time	1.3	1.5	3.5	-0.9	0.4	1.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	1.1	-1.8	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.4	1.0	-0.2	1.8
Arm fat percentage (left)	1.3	5.3	15.6	-0.4	0.5	3.9
Mineral and other dietary supplements	1.3	1.8	3.2	1.8	-1.3	0.6
Medication: Bendroflumethiazide	1.3	2.0	4.9	-1.0	-0.1	-2.2
Commuting to job workplace: Cycle	1.3	1.6	3.4	-0.8	-1.9	-0.9
Bipolar Disorder or Schizophrenia	1.2	2.9	6.8	2.6	-0.8	1.0
Vitamin and mineral supplements	1.2	1.6	2.2	-1.1	-1.5	1.2
Fluid intelligence score	1.2	2.5	3.8	1.9	-0.3	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.9	1.7	1.2	1.1
Medication: Blood pressure	1.2	2.2	2.7	-1.5	-1.6	-1.2
Number of self-reported non-cancer illnesses	1.2	2.1	6.2	2.5	0.2	-0.3
Intelligence (Savage-Jansen 2018)	1.1	3.4	8.5	2.9	-0.2	1.3
Lupus	1.1	1.7	3.8	-0.2	1.1	-1.9
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.0	-0.5	1.7	-0.7
Trunk fat percentage	1.1	4.3	12.3	-0.8	0.0	3.5
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.3	2.3	-0.8	1.2
Pain all over the body in last month	1.1	1.2	3.2	-1.8	-0.3	0.5
Medication: Allopurinol	1.1	1.5	4.5	0.2	0.1	-2.1
Whole body fat-free mass	1.1	6.5	10.7	-3.3	-0.7	-2.9
Whole body water mass	1.1	6.3	10.1	-3.2	-0.7	-2.9
Financial situation satisfaction	1.1	1.3	3.6	1.9	-0.4	0.4
Medication: Lisinopril	1.1	1.5	4.1	0.4	-2.0	-0.3
Rheumatoid Arthritis	1.0	1.4	2.6	-1.6	-1.2	0.4
Triglycerides	1.0	1.7	4.2	0.5	-2.1	-0.7
Blood Eosinophil Count	1.0	7.7	17.2	4.1	-0.1	2.4
Blood White Count	1.0	7.5	16.9	4.1	-0.2	2.4
Hearing difficulty/problems with background noise	1.0	1.6	4.5	2.1	0.6	-0.1
Medication: Ramipril	1.0	1.3	2.4	-1.2	0.1	-1.5
Birth weight of first child	1.0	1.8	2.8	-1.6	-0.2	-1.7
Arm predicted mass (right)	1.0	5.4	8.0	-2.8	-0.5	-2.8
Breast cancer (self-reported)	1.0	1.1	2.7	0.8	1.6	-0.4
Ever taken oral contraceptive pill	1.0	1.1	3.1	-0.5	1.8	-0.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.0	-1.7	-0.4	-0.9
Depressed Affect (Nagel 2018)	0.9	1.8	5.1	-2.2	0.4	0.6
Alzheimer’s Disease (in father)	0.9	1.0	1.9	1.4	1.1	0.1
Ovarian Cancer	0.9	1.2	2.4	0.9	-1.6	0.7
Prostate Cancer	0.9	1.2	2.1	1.2	-0.3	1.5
Primary Biliary Cirrhosis	0.9	1.2	2.2	-1.5	-0.5	1.1
Average weekly spirits intake	0.9	1.2	1.9	0.2	-1.2	1.4
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.8	-0.7	0.8	1.3
Happiness	0.9	1.1	2.6	1.6	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.6	-2.2	-0.7	-0.5
High blood pressure (siblings)	0.9	1.3	1.8	-1.3	1.2	0.8
Arm fat-free mass (right)	0.9	4.5	6.6	-2.5	-0.6	-2.6
Emphysema/chronic bronchitis	0.9	1.0	1.9	1.4	-0.9	-0.5
Leg fat mass (right)	0.9	3.5	5.5	-2.3	0.6	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.1	-0.2	-1.8	-0.2
Knee pain experienced in last month	0.9	1.4	2.7	1.1	1.6	0.7
Osteoporosis (self-reported)	0.9	1.2	1.9	-1.4	1.0	0.7
Eye problems/disorders: Glaucoma	0.9	1.0	2.4	0.4	-0.7	-1.6
Basal metabolic rate	0.9	5.1	9.8	-3.1	-0.7	-2.2
Arm fat-free mass (left)	0.9	4.7	8.6	-2.9	-0.9	-2.2
Number of operations (self-reported)	0.9	1.4	4.1	2.0	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.7	0.7	0.2	-1.6
Arm predicted mass (left)	0.9	4.8	8.4	-2.9	-1.0	-2.2
Major Depression (MDD)	0.8	0.9	1.3	1.1	1.1	-0.5
Crohns Disease (2012)	0.8	1.3	2.5	1.2	0.4	1.6
Hypothyroidism (self reported)	0.8	1.8	4.8	-2.2	-0.6	-0.4
Leg fat-free mass (left)	0.8	4.2	10.3	-3.2	-0.4	-1.4
Average weekly fortified wine intake	0.8	0.9	1.3	-1.1	-1.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.6	0.5	-0.0	1.6
Multivitamins +/- minerals	0.8	1.0	1.3	1.0	1.1	-0.9
Body mass index (BMI)	0.8	3.3	9.2	-0.7	0.5	3.0
Leg predicted mass (left)	0.8	4.0	9.9	-3.1	-0.4	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.0	2.0	-1.3	0.2
Noisy workplace	0.8	1.0	2.2	0.6	-0.6	-1.5
Exposure to tobacco smoke at home	0.8	0.9	2.2	0.6	1.5	0.1
Gout (self-reported)	0.8	1.2	2.4	0.4	-1.0	-1.5
Leg pain on walking	0.8	1.0	2.2	-1.5	0.1	-0.9
Leg fat-free mass (right)	0.8	4.4	10.0	-3.2	-0.5	-1.7
Leg predicted mass (right)	0.8	4.5	10.3	-3.2	-0.5	-1.7
Miserableness	0.8	1.3	3.6	-1.9	-0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	0.7	-1.4	-0.7
Diastolic blood pressure, automated reading	0.8	2.5	6.2	-2.5	0.4	1.1
Leg fat mass (left)	0.8	3.2	5.0	-2.2	0.4	2.1
Crohns Disease (2017)	0.7	1.4	3.7	1.9	0.4	0.7
Fasting Glucose	0.7	0.9	1.2	-1.1	1.0	0.7
HDL Cholesterol	0.7	1.1	3.0	0.4	0.2	1.7
BMI	0.7	3.9	11.7	-0.2	0.3	3.4
Lung FVC	0.7	3.8	6.3	0.5	2.2	2.5
Number of treatments/medications taken	0.7	1.2	2.8	-0.2	1.0	-1.7
Systolic blood pressure, automated reading	0.7	2.2	4.8	-1.1	-0.6	2.2
Angina	0.7	0.9	1.0	1.0	0.8	-1.0
Diabetes (mother)	0.7	0.9	2.2	0.4	-1.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.1	1.2	-1.8	-0.5
Illnesses of siblings	0.7	1.0	2.3	1.5	-0.0	-0.9
Number of live births	0.7	1.0	2.4	0.4	-0.6	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.8	1.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.8	1.7	-0.4	0.7
Number of children fathered	0.7	0.8	1.2	-0.6	1.1	-0.9
Qualifications: College or University degree	0.7	2.1	5.6	2.4	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	0.8	-1.1	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.2	-0.7	1.1	-0.9
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.3	1.0	1.1	0.6
Osteoarthritis (self-reported)	0.7	0.9	2.5	1.6	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	-0.6	-0.5	-1.3
Myopia	0.7	1.1	2.9	1.7	-0.1	0.6
Cholesterol lowering medication	0.7	1.0	2.5	1.6	-0.5	0.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	1.4	0.4	-0.3
Breast Cancer	0.6	1.4	2.3	1.4	-0.2	-1.5
Waist Hip Ratio (WHR)	0.6	2.6	7.6	0.2	0.1	-2.8
Severe depression (siblings)	0.6	0.7	2.1	1.5	0.1	0.1
Townsend deprivation index at recruitment	0.6	0.8	1.0	0.7	1.0	1.0
Fed-up feelings	0.6	1.1	2.5	-0.7	0.6	1.6
Supplements: Glucosamine	0.6	0.7	2.1	-0.2	1.4	0.4
Sitting height	0.6	4.6	7.1	-2.7	-1.4	-2.2
Nervous feelings	0.6	1.1	2.3	1.0	0.2	1.5
Medication: Simvastatin	0.6	0.9	2.7	1.6	0.1	-0.3
Pulse rate	0.6	1.1	2.8	-0.3	1.7	0.5
Illnesses of mother	0.6	0.8	1.7	-0.5	-1.3	-0.6
Arm fat mass (right)	0.6	2.5	5.0	-1.5	-0.1	2.2
Breastfed as a baby	0.6	0.7	1.9	1.4	-0.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	0.0	0.9	1.5
Medication: Paracetamol	0.6	1.0	1.8	0.3	-1.0	1.3
Headache pain in last month	0.6	1.0	2.3	0.6	1.5	0.6
Number of full brothers	0.6	0.7	1.6	-1.3	-0.3	-0.8
Angina (self-reported)	0.6	0.8	1.3	1.2	0.7	-0.8
Medication: Omeprazole	0.6	0.7	1.2	1.1	-0.1	0.9
Whole body fat mass	0.6	2.5	4.6	-1.7	0.2	2.1
Pulse rate, automated reading	0.6	2.1	5.5	0.8	0.2	2.4
Age at last live birth	0.6	0.9	2.1	-1.4	0.6	0.6
Commuting to job workplace: Walk	0.6	0.7	1.5	0.5	-0.5	1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	-0.3	-1.3	-0.6
Medication: Paracetamol	0.6	0.9	2.1	0.8	-0.3	1.4
Irritability	0.6	1.0	1.5	-1.1	-0.5	1.2
Age started oral contraceptive pill	0.6	0.7	2.1	-1.4	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.0	1.0	-0.5	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	1.3	-0.3	0.6
Bipolar Disorder (2018)	0.5	0.8	1.9	1.4	-0.4	-0.4
Age at First Birth	0.5	0.8	2.1	1.5	0.5	0.1
Bipolar Disorder (2011)	0.5	0.5	1.1	-1.0	-0.6	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-0.4	0.5	1.2
Mean Putamen Volume	0.5	0.6	1.6	1.3	0.3	-0.4
Sensitivity / hurt feelings	0.5	0.9	2.1	0.6	-0.2	1.5
Maternal smoking around birth	0.5	0.7	1.1	0.9	1.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.0	1.0	1.0	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.5	-0.5	0.2	-1.2
High blood pressure (mother)	0.5	0.7	1.1	-0.8	1.1	0.5
Trunk fat mass	0.5	2.3	4.4	-1.6	-0.0	2.1
Hip circumference	0.5	2.2	4.0	-1.6	-0.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	-0.0	0.9	1.2
Depression (self-reported)	0.5	0.7	1.0	0.7	-1.0	-0.6
Lung cancer (father)	0.5	0.5	1.1	-0.6	-1.0	0.4
Peak expiratory flow (PEF)	0.5	1.2	1.9	-1.4	-0.3	-1.3
Medication: Amlodipine	0.5	0.7	1.3	-0.7	-1.1	0.5
Comparative body size at age 10	0.5	1.4	3.0	-0.5	0.9	-1.7
Shortness of breath walking on level ground	0.5	0.6	1.9	0.1	-0.1	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-0.9	-1.0	-0.1
Medication: Gliclazide	0.5	0.6	1.7	0.1	-1.3	-0.1
Arm fat mass (left)	0.5	1.9	4.5	-1.0	-0.2	2.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	1.6	-0.2	0.6
Cardiovascular Disease	0.4	1.2	2.2	-1.1	0.4	1.5
Lung FEV1/FVC ratio	0.4	2.1	5.6	-0.9	-0.2	-2.4
Medication for hormone replacement therapy	0.4	0.4	0.7	-0.2	0.7	-0.8
Relative age voice broke	0.4	0.6	1.0	1.0	-1.0	-0.1
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.4	1.1	0.4
Medication: Atenolol	0.4	0.5	0.7	-0.8	-0.3	-0.8
Number of incorrect matches in round	0.4	0.7	1.7	-1.3	0.7	0.0
Alcohol usually taken with meals	0.4	0.6	1.8	1.4	-0.1	-0.3
Had menopause	0.4	0.5	0.9	-0.7	-1.0	0.2
Weight	0.4	1.9	5.5	-2.3	-0.3	0.0
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.3	-1.3	0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.3	1.1	-0.1	1.1
Medication: Cholesterol lowering	0.4	0.6	1.8	-0.2	1.4	-0.1
Blood clot in the leg (DVT)	0.4	0.6	1.6	1.3	-0.3	0.1
Worry too long after embarrassment	0.4	0.7	1.2	0.7	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.6	0.5	-1.0
Heart disease (mother)	0.4	0.5	0.6	-0.7	-0.8	0.7
Suffer from ‘nerves’	0.4	0.6	1.4	1.2	-0.7	-0.1
Supplements: Vitamin C	0.4	0.4	1.1	0.4	1.0	-0.0
Diabetes diagnosed by doctor	0.4	0.7	1.9	1.4	-0.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-0.3	0.1	1.3
Back pain experienced in last month	0.4	0.6	0.8	0.8	0.6	0.9
Average weekly champagne plus white wine intake	0.4	0.5	1.4	1.2	0.3	0.3
Mother’s age at death	0.4	0.4	1.0	1.0	0.3	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.0	1.1	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-0.2	-1.0	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	1.0	-0.3	0.4
LDL Cholesterol	0.3	0.5	0.8	0.7	0.9	-0.2
Systolic Blood Pressure	0.3	1.4	2.8	-1.7	-1.1	-0.0
Relative age of first facial hair	0.3	0.6	1.2	1.1	0.7	0.2
Current tobacco smoking	0.3	0.5	1.0	0.6	-1.0	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.7	0.8	-0.2
Heart attack	0.3	0.3	0.8	-0.1	-0.9	-0.4
Worrier / anxious feelings	0.3	0.6	0.9	-0.1	0.9	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.4	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.3	-1.5	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.1	-1.8	0.3	-0.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	1.3	0.6	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	-0.5	1.2	-0.0
Number of full sisters	0.3	0.3	0.7	-0.5	0.0	0.8
Loneliness, isolation	0.3	0.4	0.6	0.0	-0.7	0.8
Ever had bowel cancer screening	0.3	0.4	0.6	-0.8	0.7	0.0
Commuting to job workplace: Public transport	0.3	0.3	0.5	0.7	0.4	0.6
High cholesterol (Self-reported)	0.3	0.6	1.0	1.0	0.6	0.7
Medication: Atorvastatin	0.3	0.4	0.7	0.6	-0.4	0.8
Alcohol drinker status: Never	0.3	0.4	0.6	0.4	0.7	0.7
Ever depressed for a whole week	0.3	0.3	1.0	0.2	0.2	-1.0
Worry (Nagel 2018)	0.2	0.4	0.6	0.3	0.7	-0.8
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.9	0.0	0.6
Neuroticism (2016)	0.2	0.3	0.7	0.4	-0.4	-0.8
Smoking Status	0.2	0.5	0.9	0.9	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	0.2	-0.1	-0.9
Medication: Metformin	0.2	0.2	0.4	0.7	-0.5	-0.0
High blood pressure	0.2	0.5	0.9	-0.7	0.0	0.9
Waist circumference	0.2	0.6	1.0	-1.0	0.0	0.9
Forced vital capacity (FVC)	0.2	0.6	0.8	-0.9	0.7	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.6	0.2	0.8	0.6
Diabetes (self-reported)	0.2	0.3	0.8	0.9	0.1	-0.1
Time employed in main current job	0.2	0.3	0.4	0.6	-0.3	-0.6
Tense / ‘highly strung’	0.2	0.3	0.5	0.6	-0.7	0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	-1.4	0.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.5	-0.4	0.4
Age at first live birth	0.2	0.3	0.5	-0.7	-0.4	0.4
Health satisfaction	0.2	0.2	0.3	-0.5	-0.5	0.3
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.0	-0.8	-0.4
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.6	0.1
Migraine (self-reported)	0.2	0.3	0.5	0.7	-0.5	0.2
Chest pain or discomfort	0.2	0.3	0.5	0.4	0.5	0.7
Medication: Aspirin	0.2	0.2	0.4	0.6	-0.5	-0.0
Hypertension (Self-reported)	0.2	0.5	0.7	-0.7	-0.4	0.8
Smoking status: Current	0.2	0.4	0.7	0.4	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	-0.6	0.8	0.4
Hearing aid user	0.2	0.3	0.8	0.9	0.2	0.0
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	0.2	-0.7
Pain experienced in last month	0.2	0.4	1.1	0.2	-1.1	0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.2	-0.8	0.2
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	0.2	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.7	0.3	0.2
Neuroticism	0.1	0.2	0.3	-0.3	0.6	-0.2
Hair Pigment	0.1	2.7	6.6	0.9	-0.7	2.6
Tanning	0.1	1.7	3.9	2.0	1.1	0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.7	-0.1	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.2	0.0	-0.6
Past tobacco smoking	0.1	0.2	0.5	-0.7	0.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.1	-0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.3	-0.1	-0.5
Impedance of arm (right)	0.1	0.6	1.6	0.3	-0.3	1.3
Prospective memory result	0.1	0.1	0.1	-0.1	0.4	-0.2
Impedance of arm (left)	0.1	0.5	0.8	0.7	-0.4	0.9
Length of working week for main job	0.1	0.2	0.4	0.1	-0.3	0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	0.1	-0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.4	0.1
Glaucoma (self-reported)	0.1	0.1	0.3	0.4	-0.6	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	-0.2	-0.4
Birth weight	0.1	0.1	0.4	-0.3	-0.0	0.6
Exposure to tobacco smoke outside home	0.1	0.2	0.4	-0.6	0.3	0.4
Alcohol intake frequency.	0.1	0.3	0.6	0.1	-0.8	0.4
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	0.0	0.5
Medication for cholesterol	0.1	0.1	0.3	-0.2	0.0	0.5
Medication: Aspirin	0.1	0.1	0.2	0.1	-0.5	-0.1
Guilty feelings	0.1	0.2	0.5	-0.7	0.1	0.2
Medication: Blood pressure	0.1	0.2	0.3	0.5	-0.6	0.4
Ever smoked	0.1	0.2	0.4	0.1	-0.3	-0.6
Risk taking	0.1	0.2	0.3	-0.5	0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.1	-0.4	-0.6
Impedance of whole body	0.1	0.4	0.7	0.8	-0.2	0.6
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.1	-0.3	0.3
Ulcerative Colitis	0.0	0.1	0.1	-0.2	0.2	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.1	-0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.1	0.0	0.1
Supplements: Zinc	0.0	0.1	0.1	-0.1	0.4	-0.1
Impedance of leg (right)	0.0	0.1	0.2	0.5	0.2	0.1
Impedance of leg (left)	0.0	0.2	0.4	0.6	0.2	0.2
Neuroticism score	0.0	0.0	0.1	0.3	-0.1	0.1
Smoking status: Previous	0.0	0.0	0.1	0.1	-0.2	-0.1
Mood swings	0.0	0.1	0.1	-0.3	0.3	0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.2	-0.1	-0.2	0.4

Hub : Genes

PPP1R36

Models

Trait associations