TWAS hub - FUT8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0650	0.0220	2.6e-04	0.018	0.030	0.017	0.028	0.017	2.5e-03	1.2e-04	3.4e-03	2.0e-04	3.4e-03
2	GTEx	Artery Aorta	0.1310	0.0520	2.5e-03	0.007	NA	0.002	NA	0.001	1.2e-01	NA	2.5e-01	NA	2.7e-01
3	GTEx	Lung	0.1280	0.0365	8.7e-06	0.098	NA	0.061	NA	0.073	6.4e-08	NA	1.9e-05	NA	2.9e-06
4	GTEx	Spleen	0.1660	0.0730	5.3e-03	0.028	NA	-0.004	NA	0.020	6.4e-02	NA	4.2e-01	NA	9.9e-02
5	NTR	Blood	0.0301	0.0104	1.4e-04	0.000	0.012	0.010	0.013	0.002	2.6e-01	7.2e-05	3.0e-04	4.2e-05	7.8e-02
6	YFS	Blood	0.0377	0.0115	3.0e-08	0.033	0.025	0.036	0.029	0.036	4.3e-11	6.9e-09	7.2e-12	8.6e-10	8.6e-12
7	TCGA	Brain Lower Grade Glioma	0.0417	0.0274	2.9e-03	0.024	0.015	0.009	NA	0.018	7.9e-04	6.8e-03	3.2e-02	NA	3.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Qualifications: NVQ or HND or HNC or equivalent	4.3	5.2	9.9	-1.2	-1.6	-2.8	-3.0	0.0	-3.1	-2.4
Relative age voice broke	3.4	5.2	10.3	1.5	1.2	2.5	3.2	-1.4	2.8	2.5
Overall health rating	3.4	7.2	13.8	-2.3	-3.1	-3.0	-2.1	0.4	-2.9	-3.7
Alcohol intake frequency.	3.2	7.4	12.5	-3.0	-2.6	-3.5	-2.5	-0.1	-3.3	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	7.9	-1.5	-1.5	-1.8	-2.3	1.5	-2.0	-2.8
Ever depressed for a whole week	3.1	3.8	5.3	1.8	1.4	1.7	2.3	-2.0	2.1	2.1
Alzheimer’s Disease (in mother)	3.0	3.5	5.9	2.4	1.3	2.2	1.7	0.4	2.4	1.8
Stomach or abdominal pain in last month	3.0	3.7	7.1	-1.4	-1.7	-2.7	-2.0	0.4	-2.0	-2.4
Blood Platelet Count	2.8	32.1	64.8	8.1	6.9	3.7	5.3	-3.7	5.0	5.7
Body mass index (BMI)	2.8	11.8	21.6	-1.8	-3.0	-4.1	-4.0	-0.9	-4.6	-3.9
Rheumatoid Arthritis	2.7	3.7	5.7	-2.3	-1.7	-2.3	-1.0	-1.6	-2.4	-1.6
BMI	2.5	14.8	26.3	-2.0	-3.6	-4.6	-4.3	-0.9	-5.1	-4.5
Heart disease (mother)	2.5	3.1	9.2	-2.1	-3.0	-0.8	0.5	-2.4	-1.0	-0.5
Gout (self-reported)	2.4	3.2	9.8	-1.6	-3.1	-1.5	-0.5	-1.9	-1.5	-1.5
Lupus	2.3	3.4	6.2	-2.0	-2.5	-2.0	-1.1	-0.2	-2.3	-1.9
Age when periods started (menarche)	2.3	5.4	8.4	2.9	2.8	2.4	1.5	2.9	2.0	1.0
Pulse wave peak to peak time	2.3	2.7	4.8	0.8	2.0	2.2	1.5	-0.1	2.2	1.6
Diabetes (father)	2.2	2.7	5.3	-1.6	-2.0	-1.6	-0.9	-0.3	-1.8	-2.3
Leg fat mass (left)	2.2	8.4	13.0	-2.2	-3.1	-3.1	-3.0	-0.0	-3.6	-3.6
HDL Cholesterol	2.1	3.5	8.4	1.6	2.9	1.9	1.1	0.4	2.1	2.1
Forced vital capacity (FVC)	2.1	8.3	16.3	1.4	1.9	3.6	3.4	-0.2	4.0	3.3
Pulse rate, automated reading	2.1	6.7	11.8	-2.0	-1.4	-2.3	-3.3	2.5	-2.6	-3.4
Friendships satisfaction	2.1	2.6	4.7	1.4	1.6	1.7	1.3	-1.5	1.5	2.2
Birth weight of first child	2.0	3.7	8.6	0.1	-0.1	1.6	2.9	-2.5	1.3	2.6
Glaucoma (self-reported)	2.0	2.3	5.2	0.4	0.8	1.3	2.0	-1.8	1.3	2.3
Exposure to tobacco smoke outside home	2.0	2.7	11.0	-1.3	-2.1	-1.1	-0.0	-3.3	-0.5	-0.3
Leg fat mass (right)	2.0	7.9	12.2	-2.2	-3.0	-3.0	-2.9	-0.2	-3.5	-3.4
Number of self-reported non-cancer illnesses	2.0	3.5	5.7	-1.3	-1.9	-2.4	-2.0	-0.3	-1.9	-2.3
Mean Putamen Volume	1.9	2.1	3.6	1.8	1.0	1.4	1.7	0.4	1.9	1.5
Relative age of first facial hair	1.9	4.0	7.9	1.1	1.3	1.7	2.6	-1.6	2.3	2.8
Pulse wave Arterial Stiffness index	1.9	2.2	4.0	-0.9	-1.9	-2.0	-1.3	0.2	-1.9	-1.3
Forced vital capacity (FVC), Best measure	1.9	7.1	14.4	1.7	2.0	3.1	2.9	-0.2	3.8	3.3
Arm fat mass (right)	1.8	7.4	12.4	-1.6	-2.4	-3.0	-3.4	-0.0	-3.5	-3.2
Birth weight	1.8	3.9	7.4	0.4	1.6	2.7	2.5	-0.4	2.3	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.2	2.3	1.8	1.2	0.4	1.8	0.9	0.9
Medication: Omeprazole	1.8	2.2	5.0	-0.7	-0.8	-2.2	-2.1	-0.1	-1.6	-1.5
Osteoporosis (self-reported)	1.8	2.2	4.8	2.2	0.9	1.8	1.6	-0.3	1.7	1.1
Average weekly beer plus cider intake	1.8	2.7	4.2	1.8	1.6	1.8	1.4	-0.5	1.9	2.0
Arm fat mass (left)	1.7	6.9	12.5	-1.4	-2.4	-2.8	-3.2	-0.2	-3.5	-3.1
Leg fat percentage (left)	1.7	6.3	11.0	-1.3	-2.4	-2.6	-2.9	0.2	-3.3	-3.2
Lung FVC	1.6	8.1	11.2	2.7	2.6	2.8	3.0	-2.4	2.9	3.3
Alcohol intake versus 10 years previously	1.6	2.4	4.1	-0.5	-1.5	-2.0	-1.5	0.6	-2.0	-2.0
Leg fat percentage (right)	1.6	5.9	10.2	-1.5	-2.3	-2.6	-2.7	-0.0	-3.2	-3.0
Whole body fat mass	1.6	6.6	10.6	-1.9	-2.5	-2.7	-3.0	0.1	-3.3	-3.0
Arm fat percentage (right)	1.5	6.0	11.8	-0.8	-1.7	-2.7	-3.4	-0.3	-3.4	-2.8
Number of full brothers	1.5	1.9	4.4	0.2	0.8	1.4	2.1	-1.2	0.9	1.9
Diastolic blood pressure, automated reading	1.5	4.5	7.1	-2.7	-2.5	-1.8	-2.2	0.9	-2.1	-2.3
Primary Biliary Cirrhosis	1.4	2.0	4.5	1.6	2.1	1.4	1.2	-0.4	1.3	1.3
Weight	1.4	7.0	11.5	-2.7	-3.4	-2.7	-2.3	-0.1	-2.8	-3.0
Time employed in main current job	1.4	1.6	2.9	-1.7	-1.4	-1.3	-1.1	-0.1	-0.8	-1.6
Noisy workplace	1.4	1.8	3.7	-0.8	-1.2	-1.4	-1.4	0.3	-1.9	-1.5
Mouth/teeth dental problems: Dentures	1.4	2.4	4.6	-1.3	-0.9	-1.9	-1.5	0.7	-1.9	-2.1
Impedance of arm (left)	1.4	6.3	9.4	1.8	3.0	3.0	1.8	1.0	3.1	3.1
Body fat percentage	1.4	5.6	10.7	-1.3	-1.9	-2.5	-3.1	0.1	-3.3	-2.8
Worry too long after embarrassment	1.4	2.3	3.7	1.0	1.7	1.6	0.5	-1.6	1.7	1.9
High cholesterol (Self-reported)	1.4	2.5	9.0	0.2	-0.0	0.9	2.0	-3.0	0.9	1.7
Cholesterol lowering medication	1.4	2.0	3.7	1.3	0.1	1.2	1.9	-1.7	1.3	1.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.9	-0.6	-0.5	-1.9	-2.0	-1.1	-1.4	-0.6
Alzheimer’s Disease (including proxy)	1.3	1.9	4.0	2.0	1.7	1.4	0.5	1.1	1.6	1.0
Body Mass Index (BMI) (2010)	1.3	1.7	3.5	-0.4	-0.1	-1.8	-1.8	-0.8	-1.9	-1.1
Hypothyroidism (self reported)	1.3	3.0	5.3	-2.3	-1.8	-2.1	-1.2	0.2	-1.7	-1.9
High blood pressure (mother)	1.3	1.9	3.7	0.9	0.7	1.0	1.9	-1.9	0.5	1.8
Number of incorrect matches in round	1.3	2.1	3.5	-1.6	-1.4	-1.6	-1.6	0.2	-1.2	-1.9
Qualifications: A levels/AS levels or equivalent	1.3	2.9	8.0	1.3	0.7	1.2	1.9	-2.8	1.6	1.8
Tense / ‘highly strung’	1.3	2.1	5.5	-0.3	0.3	-1.0	-2.3	2.3	-0.8	-1.5
Arm fat percentage (left)	1.3	5.3	11.2	-0.4	-1.4	-2.4	-3.3	-0.2	-3.3	-2.6
Ever taken oral contraceptive pill	1.3	1.5	2.4	-1.5	-1.1	-1.2	-1.3	0.4	-1.4	-1.2
Alcohol drinker status: Previous	1.3	1.5	3.0	-1.0	-0.5	-1.7	-1.3	0.9	-1.5	-1.3
Neuroticism (2016)	1.2	1.7	2.8	-0.8	-1.2	-1.6	-1.3	0.4	-1.6	-1.7
Systolic blood pressure, automated reading	1.2	3.5	5.6	-2.2	-2.1	-1.8	-1.5	-0.2	-2.4	-1.9
Hayfever, allergic rhinitis or eczema	1.2	2.7	4.0	-1.7	-1.7	-1.9	-1.8	0.1	-1.5	-2.0
Waist circumference	1.2	4.3	6.6	-1.1	-2.4	-2.4	-2.5	-0.3	-2.6	-2.1
Nervous feelings	1.2	2.2	9.5	0.1	0.5	-0.4	-2.0	3.1	-0.6	-1.2
Medication: Lansoprazole	1.2	1.4	3.3	1.5	1.8	1.1	0.5	0.9	1.0	1.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.6	-1.6	-1.4	-1.9	-1.3	0.4	-1.5	-1.9
Medication: Allopurinol	1.2	1.6	5.9	-1.3	-2.4	-0.8	0.1	-1.3	-0.7	-0.9
Medication: Gliclazide	1.2	1.4	5.4	2.3	1.2	1.0	-0.0	1.0	0.9	0.1
Trunk fat percentage	1.1	4.5	9.0	-1.2	-1.5	-2.3	-3.0	0.2	-2.9	-2.3
Trunk fat mass	1.1	4.8	7.4	-1.8	-2.2	-2.3	-2.7	0.1	-2.7	-2.4
Pulse rate	1.1	1.8	4.3	-2.1	-1.1	-1.3	-1.7	-0.3	-1.3	-0.9
Hearing aid user	1.1	1.2	5.4	0.3	1.4	-0.0	-1.0	2.3	0.4	-0.2
Depressed Affect (Nagel 2018)	1.0	2.1	3.5	-1.9	-1.6	-1.6	-1.1	-1.6	-1.2	-0.9
Lung FEV1/FVC ratio	1.0	4.9	8.1	-1.7	-0.6	-2.4	-2.8	2.3	-2.3	-2.6
Supplements: Glucosamine	1.0	1.2	2.6	-1.3	-0.0	-1.5	-1.6	0.7	-1.0	-0.8
Hair/balding pattern: Pattern 2	1.0	1.3	2.4	-0.5	-0.8	-1.4	-1.6	0.4	-1.3	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.7	-1.4	-1.7	-1.6	-0.4	-1.0	-1.9	-1.8
Allergy	1.0	2.3	4.2	1.3	1.6	1.8	1.7	-0.4	1.2	2.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.4	0.2	-1.4	-0.8	-0.9	0.8	-0.9	-2.1
Leg pain on walking	1.0	1.2	2.5	1.2	1.6	0.8	0.6	-0.4	1.3	1.3
Commuting to job workplace: Walk	1.0	1.1	2.2	-0.7	-1.0	-1.1	-0.9	1.4	-0.4	-1.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.5	1.2	2.1	0.7	0.4	-0.1	0.3	1.2
Alcohol drinker status: Never	1.0	1.2	3.0	-0.7	-0.0	-1.7	-1.3	-0.3	-1.7	-0.7
Impedance of whole body	1.0	5.2	8.5	1.1	2.2	2.9	2.1	1.0	2.9	2.8
Bipolar Disorder (2018)	0.9	1.4	2.2	1.3	1.5	1.4	0.9	-0.3	1.2	1.4
Neuroticism (Nagel 2018)	0.9	2.2	6.1	-1.5	-1.1	-1.6	-2.5	-0.3	-1.1	-1.4
Ulcerative Colitis (UC)	0.9	1.6	4.5	1.3	2.1	0.7	-0.2	2.1	0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	0.5	-0.8	-1.4	-1.6	-1.1	-1.8	-1.4
Medication: Simvastatin	0.9	1.4	3.0	0.8	0.5	0.9	1.3	-1.5	1.1	1.7
Impedance of arm (right)	0.9	4.1	7.3	1.1	2.2	2.4	1.6	1.0	2.7	2.6
Worrier / anxious feelings	0.9	1.6	4.0	-0.8	0.7	-0.8	-1.8	2.0	-1.3	-0.9
Falls in the last year	0.9	1.2	3.1	1.8	1.6	0.7	0.2	-0.1	1.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	5.7	0.7	1.5	2.1	1.8	0.2	2.4	2.1
Loud music exposure frequency	0.9	1.0	3.6	-0.4	-1.1	-0.4	1.3	-1.9	-0.2	0.5
Comparative body size at age 10	0.9	2.4	5.5	-1.5	-2.4	-1.2	-0.2	-2.2	-1.4	-0.9
Eye problems/disorders: None of the above	0.9	1.0	1.9	1.4	0.8	0.9	0.6	0.9	1.1	1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.7	-1.5	-1.6	-0.7	0.2	-0.4	-1.0	-0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.6	-1.1	-0.4	-0.8	-1.0	-0.2	-1.9	-0.8
Number of operations (self-reported)	0.9	1.4	6.2	0.9	-0.7	0.7	0.7	-2.5	0.6	0.9
Crohns Disease (2017)	0.8	1.7	3.4	1.4	1.3	1.9	1.1	0.6	1.5	1.1
Irritable Bowel Disease (IBD)	0.8	2.0	3.2	1.4	1.8	1.7	0.8	1.4	1.6	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	-0.1	-0.8	-0.8	-1.1	0.3	-1.3	-1.4
Heel T-Score	0.8	6.5	11.9	-1.2	-2.4	-2.9	-2.9	0.2	-3.1	-3.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.3	-0.5	-0.9	-1.2	-0.8	0.3	-1.4	-1.5
Medication: Metformin	0.8	1.1	2.6	1.4	1.0	0.3	0.5	-1.6	0.6	1.3
Taking other prescription medications	0.8	1.2	1.7	-1.3	-1.2	-1.3	-0.5	-0.8	-1.2	-1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.3	-0.6	-1.5	-1.0	-0.6	-0.5	-0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.0	0.0	-0.2	-1.4	-1.4	0.6	-0.9	-1.3
Hip circumference	0.8	3.4	4.4	-2.0	-2.0	-2.1	-1.9	-0.6	-2.1	-1.8
Father’s age at death	0.8	1.0	2.1	0.6	1.0	1.3	0.7	1.4	1.2	0.6
Medication: Cholesterol lowering	0.8	1.2	3.2	0.4	0.4	0.8	1.2	-1.8	0.6	1.6
Lung cancer (father)	0.8	1.0	1.8	-1.3	-1.2	-0.5	-0.3	0.9	-1.1	-1.0
Illnesses of mother	0.8	1.0	2.8	-0.5	1.0	-1.1	-1.7	1.1	-0.3	-0.8
Exposure to tobacco smoke at home	0.8	0.9	3.4	-1.2	-0.6	-0.1	0.8	-1.8	0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.5	-0.2	1.9	0.8	0.4	-0.5	0.7	1.2
Average weekly red wine intake	0.8	1.2	3.3	1.3	1.2	1.8	0.5	0.6	1.1	0.6
Eye problems/disorders: Cataract	0.8	0.9	2.6	-1.6	-0.9	-0.7	-0.9	-0.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	6.0	1.5	2.5	0.8	-0.4	1.0	0.6	0.7
Commuting to job workplace: Public transport	0.8	1.0	2.3	1.5	0.9	0.5	0.5	-0.9	0.7	1.3
Arm fat-free mass (left)	0.8	4.1	9.9	-2.5	-3.1	-2.0	-1.0	-0.0	-1.7	-2.1
Arm predicted mass (left)	0.8	4.0	10.2	-2.5	-3.2	-1.9	-1.1	-0.2	-1.6	-2.1
Schizophrenia (2018)	0.7	1.5	2.7	1.1	1.7	-0.9	-1.6	1.4	-0.4	-0.9
Prostate Cancer	0.7	1.0	2.3	-0.8	-1.5	-0.9	0.2	-0.8	-1.4	-0.8
Blood Red Count	0.7	7.2	18.3	-0.8	0.8	2.5	3.5	-0.6	3.4	4.3
Height	0.7	13.7	30.0	-2.0	-0.2	4.8	4.5	2.9	5.5	3.1
Severe depression (siblings)	0.7	0.8	1.7	1.3	1.2	0.7	0.6	-0.5	0.6	0.9
Pack years adult smoking proportion	0.7	1.1	2.1	-0.8	-1.0	-1.0	-1.4	-0.5	-1.3	-1.1
Impedance of leg (right)	0.7	3.3	6.5	0.0	1.0	2.2	2.6	0.5	2.4	2.1
Fed-up feelings	0.7	1.2	2.7	-0.7	-1.2	-1.3	-0.9	-0.7	-1.6	-1.0
Medication: Atenolol	0.7	0.9	3.0	-0.1	-0.4	0.9	1.7	-1.1	0.4	1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	0.6	0.7	0.3	0.2	-1.1	1.5	1.1
Medication: Ramipril	0.7	0.9	3.6	-0.5	-0.5	1.0	1.9	-0.4	0.8	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.2	0.5	0.8	0.1	0.6	-1.5	1.0	1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	1.3	0.8	0.9	1.2	-0.8	0.1	0.9
Suffer from ‘nerves’	0.7	1.0	2.9	0.7	1.0	0.3	-1.7	1.6	0.5	0.0
Had major operations	0.7	0.8	4.3	-0.0	-0.4	0.1	0.9	-2.1	0.2	0.6
Illnesses of father: Heart disease	0.7	1.0	1.8	0.0	0.4	-1.3	-1.3	-1.0	-1.2	-0.8
Smoking status: Previous	0.7	1.0	5.4	-0.2	-0.9	-0.7	-0.3	-2.3	-0.6	-0.1
Mood swings	0.7	1.3	1.9	-1.4	-0.7	-1.2	-1.4	0.1	-1.2	-1.3
Diabetes diagnosed by doctor	0.7	1.2	5.8	2.4	0.8	0.1	-0.4	-1.1	-0.0	0.3
Back pain experienced in last month	0.7	1.0	1.8	-1.3	-0.9	-1.0	-0.7	0.4	-1.3	-1.2
Average weekly champagne plus white wine intake	0.7	0.9	2.8	0.2	-1.7	0.1	1.2	-1.4	-0.1	0.0
Basal metabolic rate	0.7	4.0	9.2	-2.5	-3.0	-2.0	-1.2	-0.1	-1.6	-2.0
Basal cell carcinoma (self-reported)	0.7	0.9	2.7	-1.6	-0.9	-0.8	0.1	-0.2	-1.2	-0.7
Pack years of smoking	0.7	1.0	1.4	-1.0	-1.1	-0.9	-1.2	-0.2	-1.2	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	5.0	1.7	2.2	0.1	-0.7	0.9	0.5	0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	0.1	0.9	-0.4	-1.0	1.5	-0.1	-1.1
Worry (Nagel 2018)	0.6	1.3	4.2	-1.1	-0.2	-0.4	-2.1	1.7	-0.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	1.9	1.5	0.2	0.5	-1.5	0.1	1.1
Crohns Disease (2012)	0.6	1.0	2.8	0.9	1.7	1.3	0.6	0.4	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	-0.4	-0.1	-0.3	-1.1	1.6	-0.7	-0.9
Medication for hormone replacement therapy	0.6	0.6	2.2	0.7	1.5	-0.2	-0.7	1.0	-0.5	0.3
Diabetes (mother)	0.6	0.8	2.4	-1.0	-1.6	-0.7	-0.5	0.1	-0.6	-0.9
Leg fat-free mass (left)	0.6	3.4	5.9	-2.1	-2.4	-2.1	-1.7	-0.1	-1.6	-1.9
Multivitamins +/- minerals	0.6	0.8	1.7	-0.3	0.1	-1.2	-1.3	0.7	-1.2	-0.7
Impedance of leg (left)	0.6	3.1	6.2	0.1	0.8	2.3	2.5	0.7	2.3	1.9
Leg predicted mass (left)	0.6	3.3	5.8	-2.0	-2.4	-2.0	-1.7	-0.1	-1.6	-1.9
Hair/balding pattern: Pattern 3	0.6	0.9	3.4	-1.0	-1.8	-0.9	-0.1	-0.5	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.4	0.5	1.4	1.4	1.1	0.4	2.1	1.7
Breastfed as a baby	0.6	0.7	1.7	0.4	-1.2	-0.3	0.3	-1.3	-0.9	-0.6
Hair/balding pattern: Pattern 4	0.6	1.5	5.1	0.3	1.8	1.1	-0.4	2.3	0.6	0.5
Pulse wave reflection index	0.6	0.7	1.2	0.6	-0.3	-1.0	-0.6	1.1	-1.0	-1.0
Headache pain in last month	0.6	1.0	2.3	-0.8	-0.0	-1.5	-1.4	1.0	-0.9	-0.8
Arm fat-free mass (right)	0.6	3.1	8.2	-2.3	-2.9	-1.5	-0.7	-0.2	-1.4	-1.8
Medication for pain relief, constipation, heartburn	0.6	1.0	2.5	-0.1	0.1	1.6	1.4	1.1	1.1	0.7
Knee pain experienced in last month	0.6	0.9	4.6	2.1	0.6	0.3	-0.5	-1.0	-0.3	0.1
Leg fat-free mass (right)	0.6	3.1	6.0	-1.9	-2.4	-1.9	-1.6	0.0	-1.5	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	-0.7	-1.0	0.3	1.4	-0.8	0.4	0.9
Leg predicted mass (right)	0.6	3.3	6.2	-2.0	-2.5	-2.0	-1.6	0.1	-1.5	-1.9
Medication: Atorvastatin	0.6	0.7	2.6	-0.1	-0.6	0.5	1.1	-1.6	0.1	0.7
Ever smoked	0.6	1.0	4.6	0.7	-1.1	-0.3	0.1	-2.1	-0.6	-0.6
Risk taking	0.6	0.9	1.8	0.7	1.3	1.2	0.4	0.7	1.2	0.4
Unable to work because of sickness or disability	0.6	0.8	1.8	-1.3	-0.5	-1.2	-0.4	-0.7	-1.0	-0.9
Supplements: Calcium	0.6	0.7	2.2	1.5	-0.0	0.8	0.3	0.9	1.0	0.1
Fasting Glucose	0.5	0.5	1.3	-0.3	-0.0	-0.6	-0.9	1.1	-0.5	-1.0
Ulcerative Colitis	0.5	0.7	2.2	0.5	1.3	0.0	-0.8	1.5	-0.4	-0.2
Allergy or Eczema	0.5	1.4	2.8	-0.9	-1.2	-0.9	-1.6	0.5	-0.9	-1.7
Neuroticism	0.5	1.3	2.6	-1.6	-1.1	-1.1	-1.4	-0.7	-0.9	-0.8
Chronotype (morning person)	0.5	1.2	6.7	-0.2	0.1	-0.4	-0.6	2.6	-0.4	-1.2
Number of treatments/medications taken	0.5	0.9	2.1	-0.4	-1.1	-1.4	-0.6	-1.0	-1.1	-0.3
Sensitivity / hurt feelings	0.5	0.9	3.1	0.9	1.8	0.1	-1.4	0.4	-0.3	-0.3
Angina	0.5	0.7	1.6	-0.7	-0.7	0.4	1.2	-1.3	0.7	0.7
Townsend deprivation index at recruitment	0.5	0.8	2.7	0.6	-0.2	0.3	1.0	-1.6	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.8	-1.3	-0.8	-1.1	-0.3	-0.9	-1.3	-1.1
Past tobacco smoking	0.5	0.9	4.5	-0.4	0.9	0.5	0.1	2.1	0.7	0.2
Alcohol usually taken with meals	0.5	0.7	2.3	-1.0	-1.5	-0.7	-0.7	-0.6	-0.2	-0.8
Had menopause	0.5	0.6	1.2	-1.0	-0.2	-0.9	-0.1	-1.0	-1.1	-0.3
Had other major operations	0.5	0.7	2.4	0.4	-1.6	-0.2	0.4	-1.3	0.2	-0.4
Pain all over the body in last month	0.5	0.5	1.8	-1.4	-0.4	-0.9	-0.5	0.2	-0.5	-0.6
Diabetes (self-reported)	0.5	0.8	3.2	1.8	0.7	0.2	-0.2	-1.5	-0.1	0.3
Fluid intelligence score	0.5	1.1	6.1	0.4	0.7	-0.5	0.1	-2.5	-0.2	0.8
Depression (self-reported)	0.5	0.6	1.3	-0.4	0.2	-0.7	-0.8	0.7	-0.8	-1.2
Standing height	0.5	5.4	11.2	-2.4	-1.2	2.2	2.9	1.8	3.3	1.6
Shortness of breath walking on level ground	0.5	0.6	1.4	0.6	1.0	0.7	-0.8	1.2	0.4	-0.1
Emphysema/chronic bronchitis	0.5	0.5	1.0	1.0	0.8	-0.8	-0.7	1.0	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-1.1	-0.9	-0.5	-0.5	0.2	-1.0	-1.0
Arm predicted mass (right)	0.5	2.7	6.8	-2.3	-2.6	-1.4	-0.5	-0.2	-1.2	-1.7
Whole body fat-free mass	0.5	2.8	7.7	-2.4	-2.8	-1.6	-0.7	-0.2	-0.9	-1.5
Long-standing illness, disability or infirmity	0.5	0.8	1.7	0.0	-0.4	-1.2	-1.2	-0.0	-0.9	-1.3
Medication for cholesterol	0.5	0.7	2.0	-0.7	-0.5	-0.9	-1.4	0.8	-0.3	-1.0
Whole body water mass	0.5	2.9	7.7	-2.4	-2.8	-1.6	-0.8	-0.1	-1.1	-1.6
Financial situation satisfaction	0.5	0.7	1.3	-1.0	-1.0	-0.0	0.7	-1.2	-0.2	-0.9
Irritability	0.5	0.9	2.9	0.4	0.2	-1.2	-1.7	0.8	-1.0	-0.7
Pain experienced in last month	0.5	0.9	1.5	1.0	0.9	1.0	0.9	-0.4	0.9	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.0	1.2	1.4	0.3	0.9	0.0	0.5	0.7
Major Depression (MDD)	0.4	0.4	1.5	0.7	-0.5	0.3	-1.2	0.1	0.1	-0.9
Breast Cancer	0.4	0.9	2.9	1.2	1.7	0.2	-0.2	-0.3	0.5	1.3
Age at First Birth	0.4	0.6	1.6	0.6	0.0	0.7	0.9	1.1	1.3	-0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.5	0.5	1.1	-0.3	-0.4	-1.2	-0.0	0.5
Schizophrenia (2014)	0.4	0.9	3.1	1.1	1.7	-0.5	-1.2	0.7	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.3	0.3	-0.1	-0.2	-1.1	1.5	-0.2	-0.6
Hand grip strength (right)	0.4	1.0	2.0	-1.0	-1.2	-0.4	-0.7	1.4	0.2	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	0.4	1.2	0.6	-0.0	-0.2	0.8	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.4	-0.1	0.6	-0.2	-1.2	1.5	0.5	-0.3
Financial difficulties in last 2 years	0.4	0.5	1.4	0.6	-1.2	-0.8	-0.3	-0.2	-0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	0.3	-0.4	-0.9	-1.2	-0.2	-1.1	-0.7
Trunk fat-free mass	0.4	2.2	7.6	-2.3	-2.8	-1.1	0.1	-0.3	-0.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.1	-0.3	-1.1	-1.1	-0.7	-0.5	-0.3
Trunk predicted mass	0.4	2.0	7.1	-2.3	-2.7	-1.0	0.1	-0.3	-0.3	-0.9
Peak expiratory flow (PEF)	0.4	0.9	2.2	-0.3	-0.3	-1.3	-1.5	0.6	-1.0	-0.8
Neck or shoulder pain in last month	0.4	0.5	2.0	0.1	0.7	-0.5	-1.4	0.6	-0.8	-0.2
Angina (self-reported)	0.4	0.6	1.3	-0.5	-0.4	0.5	1.1	-1.0	0.7	0.7
Family relationship satisfaction	0.4	0.4	1.1	0.3	1.0	0.3	0.1	-0.7	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	-1.2	-0.2	0.5	1.5	0.1	1.3	0.8
Loneliness, isolation	0.4	0.5	2.4	-0.6	-0.3	-0.7	-1.6	0.3	-0.3	-0.4
Smoking status: Current	0.4	0.6	2.7	1.6	0.2	0.5	0.8	-0.5	0.2	0.4
Wears glasses or contact lenses	0.4	0.5	1.3	-0.3	1.1	-0.3	-1.1	0.9	-0.2	0.3
Mother’s age at death	0.4	0.4	1.1	-0.0	-0.4	1.0	0.9	-0.3	0.9	0.3
Medication: Bendroflumethiazide	0.4	0.6	2.6	-1.6	-0.9	-0.2	0.6	-0.5	-0.3	-0.1
Commuting to job workplace: Cycle	0.4	0.5	1.8	-0.8	-1.3	-0.3	0.4	-0.5	-0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.9	1.4	0.5	-0.3	0.3	-2.0	-0.6	0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.1	0.6	-0.6	-0.8	0.3	-0.8	-0.5
HbA1C	0.3	0.3	1.3	1.1	0.6	0.8	0.0	0.1	0.1	0.2
LDL Cholesterol	0.3	0.5	1.3	-0.4	-0.9	0.5	1.2	-1.0	0.3	0.5
Smoking Status	0.3	0.8	3.7	0.9	-0.7	-0.3	0.1	-1.9	-0.6	-0.0
Average weekly spirits intake	0.3	0.4	1.1	0.3	-0.4	-0.7	-0.8	-1.0	-0.4	0.1
Medication: Co-codamol	0.3	0.4	1.7	-0.1	-0.1	0.4	1.3	0.5	0.6	0.3
Average weekly fortified wine intake	0.3	0.4	1.1	-0.6	-0.5	-0.7	-1.0	-0.1	-0.5	-0.5
Maternal smoking around birth	0.3	0.4	0.8	-0.6	-0.9	-0.7	0.3	-0.7	-0.4	-0.3
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.2	-1.0	0.3	0.7	-0.1	0.4	-0.5
High blood pressure	0.3	0.8	1.4	-1.1	-1.2	-0.7	0.1	-0.8	-1.2	-0.5
Medication: Levothyroxine sodium	0.3	0.5	1.2	-0.7	-1.0	-0.7	-0.2	0.3	-0.4	-1.1
Heart attack	0.3	0.4	1.4	0.7	1.2	0.1	0.6	0.2	0.4	0.5
Neuroticism score	0.3	0.5	2.0	-0.6	0.1	-0.6	-1.4	0.3	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	0.0	-0.1	-1.1	-1.1	-0.9	-0.5	-0.2
Asthma	0.3	0.5	1.6	0.2	-0.2	-0.5	-0.4	1.3	-0.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.7	0.4	-0.3	-1.0	0.8	-0.2	-0.8
Medication: Amlodipine	0.3	0.4	1.5	-0.0	-0.9	0.3	0.6	-1.2	0.4	0.4
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	1.1	0.2	-0.8	-0.9	-0.4	-0.8	-0.8
Age at first live birth	0.3	0.5	1.6	-0.4	-0.8	0.0	1.3	-0.9	0.2	0.2
Medication: Blood pressure	0.3	0.5	1.4	-0.5	-0.4	0.3	0.9	-1.2	0.3	0.7
Comparative height size at age 10	0.3	1.7	5.8	-2.4	-2.3	0.0	0.4	0.6	0.5	-0.2
Chest pain or discomfort	0.3	0.4	1.2	0.0	-1.1	-0.6	0.2	-0.7	-0.5	-0.7
Medication: Aspirin	0.3	0.3	0.9	1.0	0.8	-0.3	-0.5	-0.4	-0.6	-0.1
Supplements: Vitamin C	0.3	0.3	1.2	0.4	-1.1	-0.4	-0.5	-0.2	-0.4	-0.3
Illnesses of siblings: Diabetes	0.3	0.4	1.2	1.1	0.7	0.6	0.2	-0.8	0.0	0.2
Qualifications: nursing, teaching	0.3	0.5	1.8	-1.3	-0.2	-0.9	-0.8	-0.1	0.0	-0.4
Asthma (self-reported)	0.3	0.6	2.4	0.6	0.0	-0.4	-0.3	1.5	0.2	-1.2
Medication: Aspirin	0.3	0.4	1.4	1.2	0.9	-0.0	-0.4	-0.1	-0.3	-0.1
Miserableness	0.3	0.5	2.5	-0.4	-0.6	0.3	0.5	-1.6	0.1	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	1.3	-0.3	-0.6	-0.1	0.4	-1.1	0.0	0.4
Medication: Blood pressure	0.3	0.6	1.8	-0.8	-0.9	-0.3	0.7	-1.3	-0.6	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.6	-0.7	0.8	0.8	-0.6	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.0	1.2	-0.4	-0.3	-0.1	-1.1	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.3	1.1	1.0	0.7	-0.4	1.1	1.0	0.4
Heart disease (siblings)	0.3	0.4	1.5	-0.5	-0.7	-0.4	-0.1	-1.2	-0.6	-0.0
Depression (Nagel 2018)	0.2	0.3	0.8	0.3	-0.5	-0.1	-0.7	0.6	0.1	-0.9
Ovarian Cancer	0.2	0.2	0.4	0.4	-0.7	0.3	0.5	-0.6	-0.1	-0.5
Triglycerides	0.2	0.3	1.0	-0.5	-1.0	-0.2	0.3	0.2	-0.5	-0.3
Blood White Count	0.2	1.1	5.6	0.2	-0.5	-1.1	0.1	-2.4	-0.8	-0.0
Respiratory disease	0.2	0.4	1.7	0.3	-0.5	-0.4	-0.1	0.8	0.0	-1.3
Hand grip strength (left)	0.2	0.5	1.7	-1.3	-1.0	-0.5	-0.6	0.3	-0.0	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.5	0.4	0.7	0.3	0.0	0.6	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	-0.1	0.4	0.5	0.1	-0.6	0.3	0.9
Vitamin and mineral supplements	0.2	0.3	0.6	-0.4	-0.0	0.8	0.6	-0.5	0.6	0.3
Current tobacco smoking	0.2	0.3	1.5	1.2	-0.3	0.3	0.6	-0.6	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.2	0.3	-0.7	0.4	0.3	-1.1	0.5	0.0
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.3	0.5	0.6	0.6	0.8	0.6	0.1
Sitting height	0.2	1.7	4.6	-2.2	-1.5	0.8	1.2	0.6	1.5	0.6
Qualifications: None of the above	0.2	0.4	1.1	-1.1	-0.9	-0.3	-0.3	0.1	-0.4	-0.7
Illnesses of siblings	0.2	0.2	1.0	0.3	0.3	0.2	0.0	1.0	0.5	-0.2
Number of live births	0.2	0.2	0.9	-0.3	-0.2	0.4	-0.2	0.9	-0.4	-0.3
Happiness	0.2	0.2	0.3	-0.0	0.6	0.5	0.3	0.4	0.5	0.5
Prospective memory result	0.2	0.3	0.9	-0.2	0.9	0.4	-0.0	0.5	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.3	-0.1	0.1	0.9	-0.9	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.8	0.4	0.2	-0.1	-0.4	1.4	0.0	-0.1
Medication: Paracetamol	0.2	0.4	0.7	0.2	0.8	-0.8	-0.8	-0.7	-0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.2	-0.1	-0.5	-0.9	0.8	-0.5	-0.9
Qualifications: College or University degree	0.2	0.7	2.0	0.4	0.9	0.4	0.5	-1.4	0.8	1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.7	0.6	0.8	0.2	-0.1	0.7	0.1	-0.3
Mean time to correctly identify matches	0.2	0.4	1.8	-0.8	0.5	0.1	-0.5	1.4	-0.2	0.0
Number of full sisters	0.2	0.2	0.5	-0.1	-0.6	-0.4	-0.3	0.5	-0.7	-0.5
Age at last live birth	0.2	0.2	0.7	0.8	0.1	0.2	0.7	0.2	0.5	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.7	-0.5	-0.4	-0.2	-0.1	-0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.6	-0.0	-0.7	-0.7	0.2	0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.4	-0.1	1.2	0.2	-0.5	0.3	0.6	0.5
Mineral and other dietary supplements	0.2	0.3	0.5	0.2	-0.3	0.7	0.7	-0.0	0.7	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	1.2	-0.0	-0.8	0.2	0.3	1.1	0.2	-0.1
Medication: Paracetamol	0.2	0.4	0.8	-0.3	0.5	-0.9	-0.7	-0.8	-0.4	0.3
Medication: Lisinopril	0.2	0.2	0.7	-0.8	-0.1	-0.1	0.1	0.8	-0.0	-0.3
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.2	0.7	0.3	-0.1	0.5	0.5	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	-0.8	-0.2	0.1	0.3	-0.9	0.4	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.8	0.5	-0.5	0.4	0.9	0.4	0.4	-0.0
Myopia	0.2	0.3	0.8	-0.3	0.5	-0.4	-0.9	0.7	0.3	0.2
Reaction Time	0.1	0.2	0.3	-0.4	0.5	-0.3	-0.5	0.6	-0.4	0.1
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	-0.0	0.1	-0.0	-0.2	0.0	0.6
Blood Eosinophil Count	0.1	1.0	3.3	1.4	1.8	-0.6	-0.4	-0.5	-0.8	-0.0
Waist Hip Ratio (WHR)	0.1	0.5	2.5	1.6	-0.1	0.1	-0.2	0.8	-0.0	0.7
Systolic Blood Pressure	0.1	0.6	3.0	-1.7	-0.7	-0.4	0.3	0.1	-0.7	0.1
Cardiovascular Disease	0.1	0.5	1.5	0.1	-0.4	0.3	1.2	-1.0	-0.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	0.5	0.7	0.1	-0.4	-0.2	-0.2	-0.2
Supplements: Zinc	0.1	0.1	0.2	-0.1	-0.1	-0.5	-0.1	0.3	-0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.1	-0.3	0.4	0.4	-0.0	0.3	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.1	-0.3	-0.3	-0.7	-0.7	-0.7	-0.2
Mouth/teeth dental problems	0.1	0.1	0.4	-0.5	-0.6	0.3	0.1	0.1	0.4	0.3
Length of working week for main job	0.1	0.1	0.2	0.3	-0.4	-0.0	0.2	-0.4	0.0	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.8	0.0	0.3	-0.3	0.2	-0.9	0.2	-0.2
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.4	-0.6	0.1	0.1	-0.3	-0.1	-0.0
Health satisfaction	0.1	0.2	0.4	-0.6	-0.5	-0.5	-0.1	0.4	0.0	-0.6
Medication: Ibuprofen	0.1	0.1	0.4	0.1	-0.3	-0.6	-0.6	-0.1	-0.2	-0.1
Hypertension (Self-reported)	0.1	0.3	1.0	-0.4	-0.5	0.1	0.8	-1.0	-0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.7	0.2	0.4	0.1	-0.0	0.0	0.1
Ever had bowel cancer screening	0.1	0.2	0.6	0.8	-0.4	0.4	-0.0	-0.1	-0.2	-0.4
Breast cancer (self-reported)	0.1	0.1	0.8	0.9	-0.3	0.2	-0.3	0.0	-0.2	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.5	0.4	-0.1	0.1	-0.7	-0.3	-0.1	-0.1
Guilty feelings	0.1	0.1	0.3	0.6	-0.1	-0.1	-0.4	-0.3	0.2	-0.0
Age started oral contraceptive pill	0.1	0.1	0.2	-0.3	0.4	0.4	0.4	0.1	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.6	-0.3	0.2	0.0	-0.1	0.1	0.1
Hair Pigment	0.0	0.5	1.7	0.9	1.3	-0.3	-0.3	-0.3	0.2	0.9
Tanning	0.0	0.5	1.9	-0.6	-1.4	-0.7	-0.5	-0.2	-0.5	-0.5
High blood pressure (siblings)	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	-0.3	-0.2	0.3
Number of children fathered	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.2	-0.1	-0.2	0.4
Migraine (self-reported)	0.0	0.1	0.1	-0.4	0.3	0.1	0.3	-0.3	-0.0	-0.2

Hub : Genes

FUT8

Models

Trait associations