Hub : Genes

SPTB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.055 0.0200 0.00012 0.053 0.049 0.047 0.05 0.049 4.4e-07 1.1e-06 2.1e-06 9.5e-07 1.3e-06
2 GTEx Artery Aorta 0.134 0.0530 0.00610 -0.003 NA 0.010 NA 0.000 5.0e-01 NA 9.0e-02 NA 3.2e-01
3 GTEx Artery Tibial 0.140 0.0399 0.00010 0.068 NA 0.041 NA 0.046 4.8e-06 NA 3.3e-04 NA 1.6e-04
4 GTEx Pancreas 0.287 0.0820 0.00017 0.217 NA 0.206 NA 0.235 1.5e-09 NA 4.2e-09 NA 2.6e-10
5 GTEx Skin Sun Exposed Lower leg 0.122 0.0480 0.00220 0.020 NA 0.009 NA 0.028 8.6e-03 NA 5.3e-02 NA 2.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.8 1.5 -1.2 -0.3 -1.1 0.9 -0.1
Bipolar Disorder or Schizophrenia 0.4 1.1 1.9 -1.3 -0.3 -1.2 -0.0 -1.4
Depressed Affect (Nagel 2018) 0.5 1.1 3.0 0.1 1.7 -1.3 -0.5 -0.8
Depression (Nagel 2018) 0.1 0.1 0.4 -0.2 -0.2 0.0 -0.2 0.6
Intelligence (Savage-Jansen 2018) 0.5 1.7 5.3 -1.7 2.3 0.1 -0.2 -0.3
Neuroticism (Nagel 2018) 0.3 0.7 1.9 -0.1 1.4 -1.1 -0.3 -0.5
Schizophrenia (2018) 0.4 0.9 3.0 -0.7 -0.2 -0.7 -0.8 -1.7
Schizophrenia vs Biploar Disorder 1.0 1.3 3.9 0.8 -0.0 0.6 -2.0 -1.4
Worry (Nagel 2018) 0.0 0.1 0.3 0.0 0.2 -0.5 0.1 0.4
Alzheimer’s Disease (in mother) 1.6 1.8 3.6 -1.0 -0.7 1.9 1.1 1.7
Alzheimer’s Disease (in father) 3.1 3.4 7.3 -2.7 0.4 -0.1 2.6 1.7
Alzheimer’s Disease (including proxy) 1.8 2.6 4.5 -2.1 -0.4 1.4 1.9 1.7
Crohns Disease (2017) 0.2 0.4 0.6 -0.3 0.8 0.6 0.8 0.5
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 -1.1 0.7 -0.1 0.9 0.2
Ulcerative Colitis (UC) 0.3 0.6 2.5 -1.6 0.6 0.2 0.5 0.1
Major Depression (MDD) 0.7 0.9 2.4 -1.5 0.5 1.2 0.1 0.6
Reaction Time 1.1 2.2 4.0 -0.6 2.0 1.8 0.8 1.6
Verbal and Numeric Reasoning (VNR) 0.9 2.0 5.4 -2.1 2.3 -0.2 0.4 0.2
Breast Cancer 0.8 2.0 5.5 0.8 -1.8 -2.4 0.7 -0.1
Ovarian Cancer 0.4 0.5 1.5 -0.8 -1.2 0.0 0.4 0.4
Prostate Cancer 0.8 1.1 3.4 -1.8 0.5 -0.7 1.1 0.6
Age at First Birth 0.9 1.4 2.6 0.8 -1.6 0.2 -1.6 -1.0
Bipolar Disorder (2011) 1.6 1.5 3.5 0.7 -0.6 -1.3 -1.3 -1.9
Body Mass Index (BMI) (2010) 0.6 0.8 3.2 -0.7 1.8 0.3 0.3 0.1
Coronary Artery Disease (CAD) 0.9 1.1 2.6 0.6 1.6 0.8 -1.2 -0.5
Crohns Disease (2012) 0.4 0.7 1.8 -0.3 1.3 0.2 1.1 0.5
Mean Putamen Volume 1.0 1.1 2.6 -1.6 0.5 1.5 -0.4 0.7
Fasting Glucose 0.7 0.8 1.7 -0.8 0.7 1.3 0.2 1.0
HbA1C 1.2 1.4 2.5 -0.9 1.0 0.6 1.6 1.4
HDL Cholesterol 0.1 0.2 0.7 -0.4 0.8 0.3 -0.4 0.1
LDL Cholesterol 0.5 0.7 2.2 0.0 0.3 -1.5 1.1 -0.1
Lupus 0.8 1.3 2.4 -1.2 -1.0 -0.6 1.6 1.1
Neuroticism (2016) 0.3 0.4 0.8 0.9 -0.2 0.5 0.0 0.9
Primary Biliary Cirrhosis 1.1 1.5 3.0 -0.5 1.7 1.7 -0.9 -0.9
Rheumatoid Arthritis 0.7 0.9 2.9 1.7 -0.0 -1.1 -0.1 -0.6
Schizophrenia (2014) 0.6 1.2 3.2 -1.0 0.7 -0.5 -1.1 -1.8
Triglycerides 0.4 0.7 1.3 0.1 -1.1 0.6 0.8 1.0
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 -1.2 1.6 1.7 0.5 0.1
Ulcerative Colitis 0.3 0.4 1.1 -1.0 0.8 0.3 0.1 -0.4
Blood Eosinophil Count 1.6 12.4 26.7 -5.2 4.1 4.3 0.2 0.7
Blood Platelet Count 1.3 15.0 33.4 -5.7 5.8 2.1 -0.1 -2.2
Blood Red Count 1.4 13.8 51.9 7.2 -3.5 -2.2 -0.2 -0.0
Blood White Count 0.7 5.1 11.5 -2.4 2.3 3.4 1.0 1.3
Heel T-Score 0.4 2.8 8.4 -2.9 0.7 1.9 0.7 1.1
BMI 1.8 10.5 23.5 -4.8 1.9 0.5 4.3 2.6
Height 1.9 36.5 72.9 8.5 -8.2 -6.5 -0.7 -0.8
Waist Hip Ratio (WHR) 1.1 4.8 9.7 -3.0 0.1 3.1 0.7 2.2
Systolic Blood Pressure 0.8 3.8 10.5 2.7 -3.2 -0.8 -0.4 -0.3
Smoking Status 1.6 3.9 6.3 -2.5 1.8 1.2 2.2 2.0
Allergy or Eczema 0.7 1.8 4.6 -1.2 2.1 1.6 -0.3 0.6
Cardiovascular Disease 0.0 0.1 0.1 -0.2 -0.1 -0.1 0.3 0.3
Hypothyroidism (self reported) 0.3 0.6 1.7 -0.4 0.1 -1.3 -0.7 -0.8
Respiratory disease 1.0 2.2 8.1 -2.8 0.8 1.5 -0.5 0.2
Type 2 Diabetes (T2D) (2018) 1.6 3.0 6.9 -2.6 1.6 -0.7 2.0 0.9
Lung FEV1/FVC ratio 0.1 0.4 1.6 0.2 1.3 0.0 0.3 -0.4
Lung FVC 0.3 1.3 4.6 -0.1 2.2 0.8 -0.9 -0.6
Neuroticism 0.4 0.9 2.4 0.1 1.3 -1.5 -0.4 -0.5
Chronotype (morning person) 0.4 0.9 4.0 0.5 -2.0 -0.6 -0.1 -0.2
Hair Pigment 0.2 6.0 9.7 -2.3 2.1 1.0 3.1 3.1
Tanning 0.1 1.5 3.7 -0.9 0.8 -1.3 -1.0 -1.9
Hand grip strength (left) 1.1 2.8 5.4 2.2 -2.3 -1.8 0.2 -0.7
Number of treatments/medications taken 2.7 4.9 8.5 -2.4 1.5 0.5 2.9 2.8
Average weekly spirits intake 2.3 2.9 5.2 -0.8 1.6 2.0 1.5 2.3
Sensitivity / hurt feelings 1.3 2.3 4.6 -1.6 2.1 -1.7 1.1 -0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.3 -1.1 0.7 -1.0 0.7 0.6
Hearing difficulty/problems: Yes 0.8 1.2 4.0 0.7 -0.3 0.6 -2.0 -1.1
Relative age of first facial hair 0.8 1.6 4.7 -0.4 2.2 0.1 -1.5 -1.0
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 2.9 -1.3 1.7 0.8 1.1 1.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.7 -1.6 -0.3 -0.2 -0.4 -0.5
Ever had hysterectomy (womb removed) 0.4 0.4 1.1 0.0 0.8 0.6 -1.0 0.4
Systolic blood pressure, automated reading 0.2 0.6 1.2 0.9 -1.1 0.4 0.3 0.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.2 -0.3 1.1 -0.1 -0.0 -0.3
Angina 0.3 0.3 1.4 -0.1 -0.2 1.2 0.0 0.5
Medication for hormone replacement therapy 1.7 1.9 3.6 -1.7 1.9 1.0 0.7 1.3
Vitamin and mineral supplements 2.0 2.8 7.2 2.7 -1.0 -0.1 -1.9 -1.4
Supplements: Zinc 0.1 0.1 0.3 -0.5 -0.4 0.3 -0.4 0.2
Medication: Co-codamol 1.4 1.6 3.3 -1.6 0.6 -1.8 1.3 0.5
Medication: Metformin 1.0 1.4 3.4 -1.0 0.8 -1.2 1.8 0.8
Diabetes (father) 1.2 1.5 2.4 1.6 -1.4 0.9 -0.1 1.4
Diabetes (mother) 0.7 0.9 2.5 0.3 -0.9 -1.6 -0.3 -0.9
Severe depression (siblings) 1.0 1.1 2.7 -1.6 1.6 -0.2 -0.3 -0.5
Pack years adult smoking proportion 1.9 2.9 5.8 -2.3 2.4 0.4 1.6 0.8
Impedance of leg (right) 0.6 2.8 7.2 0.5 -0.4 -0.3 -2.7 -2.6
Leg fat-free mass (left) 0.8 4.1 6.2 1.7 -2.2 -0.9 2.5 2.4
Trunk fat percentage 0.8 3.1 8.2 -2.9 0.8 1.5 1.5 1.3
Hand grip strength (right) 1.2 3.1 5.8 1.7 -2.4 -2.1 1.5 0.5
Townsend deprivation index at recruitment 1.5 2.1 4.7 -2.1 2.2 -0.6 0.7 -0.4
Current tobacco smoking 1.1 1.9 5.0 -2.2 1.3 1.0 1.0 0.8
Average weekly fortified wine intake 1.7 2.0 6.5 1.0 0.7 2.5 -0.6 1.4
Maternal smoking around birth 1.3 1.9 5.2 -2.3 1.1 -0.0 1.7 0.4
Fed-up feelings 1.1 2.0 3.6 -1.6 1.9 -1.4 1.3 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.1 -0.7 0.7 -0.3 0.5 1.0
Relative age voice broke 0.4 0.6 1.8 0.6 1.3 -0.6 -0.2 -0.7
Taking other prescription medications 3.4 5.2 9.0 -3.0 2.7 0.9 1.9 2.3
Age when periods started (menarche) 0.8 1.9 7.4 -2.7 0.2 -0.9 0.8 -0.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.7 -0.8 -0.5 -0.2 -0.5 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.0 -0.6 -0.0 -1.0 2.0 0.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.4 -0.7 0.3 -0.8 -0.0
Qualifications: CSEs or equivalent 0.7 0.9 2.6 -1.0 1.6 -0.4 -0.2 -0.7
Serious illness, injury or assault to yourself 0.2 0.2 0.6 0.4 -0.0 -0.0 -0.8 -0.4
High blood pressure 0.1 0.4 0.7 0.8 -0.1 0.7 0.2 0.8
Hayfever, allergic rhinitis or eczema 0.8 1.6 4.1 -2.0 1.9 0.5 -0.5 -0.2
Multivitamins +/- minerals 0.8 1.0 4.6 -2.1 -0.1 0.0 0.5 0.2
Stomach or abdominal pain in last month 2.1 2.6 5.7 -2.4 1.7 0.7 1.5 1.3
Supplements: Glucosamine 0.7 1.0 2.5 -1.6 0.0 -1.1 1.0 0.1
Diverticular disease/diverticulitis (self-reported) 2.2 2.7 5.2 -2.1 2.3 1.7 0.3 0.7
Medication: Atenolol 0.3 0.4 0.7 0.8 -0.4 -0.7 -0.6 0.1
Medication: Levothyroxine sodium 0.3 0.5 1.6 -0.7 -1.3 -0.3 0.4 0.6
Sitting height 1.4 10.2 25.7 5.1 -4.4 -2.3 -0.7 -0.0
Chronic bronchitis/emphysema (father) 1.1 1.3 2.4 1.5 1.0 -0.6 -0.9 -1.5
High blood pressure (mother) 0.1 0.2 0.6 -0.2 0.8 0.2 0.3 0.4
Body mass index (BMI) 1.4 6.0 13.0 -3.6 1.5 1.3 2.9 2.2
Impedance of leg (left) 0.6 2.8 6.7 0.3 -0.5 -0.2 -2.6 -2.6
Leg predicted mass (left) 0.8 4.1 6.4 1.6 -2.2 -0.9 2.5 2.4
Trunk fat mass 0.5 2.1 3.7 -1.8 -0.0 0.8 1.9 1.7
Waist circumference 0.9 3.1 6.3 -2.5 0.0 0.6 2.3 2.0
Number of incorrect matches in round 0.4 0.6 1.8 -0.3 0.8 1.3 0.5 0.6
Past tobacco smoking 1.6 3.0 5.0 1.7 -1.2 -0.9 -2.2 -2.2
Alcohol usually taken with meals 0.3 0.4 0.8 -0.7 -0.8 -0.1 -0.4 -0.9
Nervous feelings 1.0 2.0 4.9 -0.6 -0.7 -2.2 -1.0 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.2 -1.5 0.9 -0.7 -0.1 -0.1
Hearing difficulty/problems with background noise 0.5 0.8 2.4 -0.3 1.6 0.8 -0.7 -0.5
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 -0.5 -0.4 0.7 0.4 0.2
Had menopause 0.3 0.3 1.3 0.3 1.1 -0.3 -0.3 -0.2
Had other major operations 0.1 0.2 0.5 -0.5 0.7 -0.2 0.1 -0.1
Forced vital capacity (FVC) 0.4 1.4 4.7 2.2 -1.1 0.2 0.3 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 3.2 -1.3 -0.5 -1.6 1.8 0.2
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 4.6 0.2 1.8 -0.3 -2.1 -1.6
Qualifications: None of the above 0.0 0.1 0.2 0.5 0.2 0.4 0.3 0.1
Financial difficulties in last 2 years 1.9 2.6 9.7 -3.1 1.5 0.7 0.0 -0.6
Mouth/teeth dental problems 1.3 2.0 4.9 2.2 -0.3 0.8 -1.8 -1.0
Heart attack 0.6 0.8 2.1 -0.0 0.7 1.4 -1.2 -0.3
Allergy 1.2 2.7 8.1 2.9 -1.9 -1.2 0.1 -0.4
Pain all over the body in last month 2.4 2.6 7.3 2.7 -0.6 -0.1 -2.1 -0.9
Diabetes (self-reported) 1.7 2.6 5.1 -2.3 2.0 -0.1 1.7 1.0
Hayfever/allergic rhinitis (self-reported) 2.8 3.8 9.3 -3.0 3.0 0.5 0.7 0.1
Medication: Ramipril 0.9 1.1 2.9 0.9 -0.7 -1.7 -0.5 -1.1
Medication: Simvastatin 0.4 0.6 1.3 -0.3 1.1 -0.3 0.9 0.8
Fluid intelligence score 1.0 2.1 4.6 -0.4 2.1 -2.1 1.1 -0.5
Illnesses of siblings 0.4 0.5 2.0 -1.4 -0.3 -0.4 0.4 -0.4
Neuroticism score 0.6 1.3 3.4 -0.4 1.6 -1.9 -0.0 -0.4
Weight 0.5 2.2 5.3 -0.4 -1.4 -0.2 2.3 1.9
Impedance of arm (right) 0.3 1.6 4.7 0.5 -0.6 -0.5 -2.2 -1.6
Arm fat percentage (right) 1.3 5.2 14.4 -3.8 1.3 1.2 2.3 1.8
Trunk fat-free mass 1.2 6.9 11.3 2.9 -3.4 -1.7 2.6 2.3
Hip circumference 0.2 0.9 2.7 -0.7 -0.2 -0.7 1.6 0.9
Time employed in main current job 0.8 0.9 2.1 -0.1 -0.8 -1.5 1.3 0.1
Alcohol intake versus 10 years previously 0.8 1.2 2.3 -1.5 -1.5 0.5 0.9 0.6
Father’s age at death 0.8 1.0 2.6 -0.2 -1.6 -1.4 -0.4 -0.6
Worrier / anxious feelings 0.6 1.1 3.1 0.3 1.2 -0.0 -1.8 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 5.2 -0.8 2.3 -0.1 -0.1 0.7
Falls in the last year 1.6 2.2 4.2 -1.6 0.6 -1.7 -0.9 -2.0
Hair/balding pattern: Pattern 3 1.1 1.7 4.3 -0.0 0.9 1.4 1.2 2.1
Number of live births 0.7 1.0 2.5 1.3 0.6 0.6 -0.3 1.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.1 2.0 -0.3 0.4 0.4 1.0
Pulse rate 0.4 0.6 2.0 0.5 1.4 0.5 -0.6 -0.4
Happiness 2.3 2.7 5.9 1.3 0.5 -1.5 -2.4 -1.9
Noisy workplace 1.8 2.3 3.5 -1.7 0.7 1.5 1.5 1.9
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.9 1.0 0.5 0.1 -0.4 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 3.1 -0.2 -0.2 1.6 0.4 1.8
Mouth/teeth dental problems: Dentures 0.7 1.2 2.2 -1.5 0.5 -1.1 1.4 0.6
Asthma 0.8 1.6 5.7 -2.4 0.4 0.9 -0.9 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.4 -1.5 0.9 0.7 1.1 0.4
Medication: Cholesterol lowering 0.4 0.7 1.7 -0.6 1.3 0.1 0.9 0.6
Depression (self-reported) 0.3 0.4 1.2 -0.5 -0.2 -1.1 0.5 -0.3
Medication: Lansoprazole 1.5 1.7 4.0 -0.9 0.6 0.3 1.8 2.0
Prospective memory result 0.8 0.9 2.8 0.6 -0.5 1.7 -1.1 0.3
Lung cancer (father) 0.3 0.3 0.9 1.0 0.1 -0.5 0.2 -0.5
Illnesses of mother 1.7 2.1 5.1 1.5 -0.4 -2.2 -0.1 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.5 1.9 -0.1 0.6 -0.2 0.8
Pulse wave Arterial Stiffness index 0.7 0.8 2.5 0.9 -1.6 0.7 0.1 0.3
Impedance of arm (left) 0.5 2.3 6.5 0.8 -0.2 -0.4 -2.6 -2.0
Arm fat mass (right) 0.9 3.7 6.9 -2.6 0.1 0.7 2.6 2.1
Trunk predicted mass 1.2 7.0 11.9 2.9 -3.5 -1.8 2.6 2.3
Standing height 2.0 19.5 44.7 6.6 -6.7 -2.9 -0.8 0.1
Length of working week for main job 0.4 0.4 1.2 -0.6 -1.1 0.7 0.3 0.1
Exposure to tobacco smoke at home 1.6 1.8 6.3 -1.0 2.5 1.2 -0.1 0.5
Breastfed as a baby 1.6 2.0 7.5 -2.7 1.3 -0.2 0.7 0.4
Tense / ‘highly strung’ 0.7 1.2 2.5 -1.2 0.7 -0.8 1.6 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 8.8 -3.0 2.0 1.0 0.8 0.6
Hair/balding pattern: Pattern 4 0.8 2.0 7.2 1.0 -1.1 -2.7 0.3 -0.9
Birth weight of first child 0.5 1.0 1.7 1.3 -1.0 1.1 0.0 1.0
Peak expiratory flow (PEF) 0.2 0.5 1.1 0.5 -0.2 -0.2 1.1 0.9
Pulse wave reflection index 0.5 0.6 2.5 -1.6 -0.5 0.4 0.4 0.2
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.3 -0.4 0.1 0.7 0.7
Loud music exposure frequency 2.1 2.2 4.8 -1.7 -0.3 -0.1 2.2 1.9
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.2 0.4 0.5 -0.5 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.0 -1.0 -0.4 -0.8 0.9 0.2
Blood clot in the leg (DVT) 0.9 1.1 2.1 -0.7 1.5 0.9 0.8 1.4
Medication: Paracetamol 3.9 6.4 9.9 -3.1 2.9 2.5 1.4 2.4
Headache pain in last month 0.3 0.6 1.0 -0.9 0.7 0.3 0.8 1.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.9 -0.9 -0.3 1.0 -0.6 0.5
Glaucoma (self-reported) 2.1 2.4 10.1 0.3 -0.1 -3.2 -0.0 -1.4
Gout (self-reported) 0.7 1.0 2.3 0.7 -1.5 0.3 1.0 1.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.9 -1.0 -0.1 -0.6 0.1 0.1
Medication: Amlodipine 1.0 1.4 3.4 0.9 -1.5 -1.9 -0.1 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 -1.1 -0.6 -0.2 0.9 0.2
Birth weight 1.3 2.9 5.4 2.0 0.6 2.3 -2.1 -0.3
Chronic bronchitis/emphysema (mother) 2.9 3.3 7.8 -2.3 2.8 1.7 0.2 0.8
High blood pressure (siblings) 1.1 1.5 3.8 1.0 -1.0 1.9 0.1 1.4
Forced vital capacity (FVC), Best measure 0.3 1.0 3.3 1.8 -0.8 0.4 -0.3 1.0
Body fat percentage 0.9 3.7 10.7 -3.3 1.3 1.6 1.5 1.1
Leg fat percentage (right) 0.8 2.8 9.5 -3.1 1.2 1.1 1.2 0.5
Arm fat-free mass (right) 0.8 4.0 6.3 1.7 -2.1 -0.7 2.5 2.4
Exposure to tobacco smoke outside home 0.3 0.5 1.0 -0.1 0.9 -0.2 1.0 0.7
Comparative body size at age 10 0.2 0.4 1.0 -0.4 -0.3 -1.0 0.9 0.5
Number of full brothers 0.4 0.5 2.2 -0.0 1.5 -0.4 -0.6 0.0
Worry too long after embarrassment 0.3 0.5 0.6 0.8 0.7 -0.8 -0.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.6 0.5 0.5 -0.5 -0.4
Wheeze or whistling in the chest in last year 1.0 1.9 5.2 -2.3 1.8 -0.2 0.6 -0.6
Number of children fathered 0.7 0.8 2.1 -0.5 0.9 1.4 0.5 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 6.0 -0.1 -2.4 1.0 -0.3 0.8
Age at first live birth 0.6 1.1 3.0 1.0 -1.7 -0.4 -0.8 -0.8
Pulse wave peak to peak time 0.4 0.5 1.1 -0.2 1.1 -1.0 -0.2 -0.3
Health satisfaction 0.8 1.1 1.9 1.4 1.2 0.7 -1.2 0.3
Shortness of breath walking on level ground 0.7 0.8 1.7 -0.1 0.7 0.4 1.3 1.2
Qualifications: College or University degree 1.2 3.7 10.1 0.4 0.5 -2.2 -1.7 -3.2
Eye problems/disorders: None of the above 0.8 0.9 2.3 -1.1 -0.7 1.5 -0.1 0.5
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.7 0.8 0.1 -1.3 -1.0 -1.3
Emphysema/chronic bronchitis 3.7 4.2 12.1 -3.5 1.1 0.9 1.7 2.0
Medication for pain relief, constipation, heartburn 3.8 6.5 13.5 3.7 -3.1 -1.6 -2.0 -1.7
Neck or shoulder pain in last month 0.9 1.2 4.9 -0.5 2.2 0.0 0.8 0.4
Medication: Blood pressure 0.5 0.8 3.0 1.7 -0.4 -0.9 0.3 -0.2
Angina (self-reported) 0.3 0.4 1.3 0.1 -0.2 1.1 0.3 0.6
Migraine (self-reported) 0.7 0.8 2.3 -1.5 0.4 -0.4 1.1 0.5
Medication: Ibuprofen 0.4 0.5 1.2 -1.1 0.3 0.6 0.8 0.3
Medication: Allopurinol 1.2 1.6 4.4 1.6 -2.1 0.0 -0.6 -0.7
Medication: Omeprazole 0.3 0.4 1.3 -1.2 0.5 0.3 -0.3 -0.5
Medication: Seretide 50 evohaler 1.1 1.2 3.9 -0.2 0.6 -0.1 -1.4 -2.0
Mean time to correctly identify matches 0.9 1.7 3.2 -0.7 1.8 1.6 0.7 1.3
Heart disease (mother) 0.6 0.7 1.7 1.3 -0.4 0.1 -1.1 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 4.2 -2.0 0.2 -0.3 -0.4 -1.0
Whole body fat mass 0.5 2.2 4.0 -2.0 0.1 0.8 2.0 1.6
Leg fat mass (right) 0.5 2.0 3.8 -1.9 0.2 0.8 1.9 1.5
Arm predicted mass (right) 0.8 3.9 5.4 2.3 -2.3 -0.8 2.1 2.0
Pulse rate, automated reading 0.7 2.2 3.2 -1.5 1.8 1.5 -1.7 -0.8
Alcohol intake frequency. 0.3 0.7 1.8 -0.2 -0.4 1.2 -1.3 -0.4
Comparative height size at age 10 1.5 8.5 20.3 4.5 -4.4 -1.6 0.1 0.8
Number of full sisters 2.4 2.9 6.0 -1.5 -0.0 0.4 2.4 2.4
Suffer from ‘nerves’ 0.7 1.1 2.1 -1.5 -0.7 -1.1 1.3 0.4
Overall health rating 1.8 3.9 7.8 -2.8 2.5 0.6 1.5 1.7
Chest pain or discomfort 1.2 1.7 4.2 -2.0 1.6 1.2 -0.2 -0.5
Had major operations 1.9 2.2 8.2 -1.6 2.9 -0.0 0.4 -0.3
Age at last live birth 0.3 0.4 1.1 1.1 -0.4 -0.1 -0.9 -0.3
Family relationship satisfaction 0.9 1.1 3.0 0.9 1.7 -0.3 -1.3 0.3
Leg pain on walking 0.2 0.2 0.6 0.4 0.8 -0.0 0.3 0.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 4.2 -0.4 0.9 2.0 -0.1 1.1
Commuting to job workplace: Car/motor vehicle 1.9 2.1 6.0 0.6 -0.4 0.8 1.9 2.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.8 0.6 0.1 -0.9 0.5 -0.5
Medication: Aspirin 2.8 3.7 5.9 -2.4 2.1 0.2 2.3 1.7
Supplements: Vitamin C 3.4 4.0 7.1 -2.7 1.7 1.4 1.9 2.0
Knee pain experienced in last month 3.2 5.0 11.0 -3.3 2.8 1.5 1.6 1.2
Hypertension (Self-reported) 0.1 0.3 0.7 0.8 -0.1 0.5 0.3 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.6 -0.7 -0.6 0.8 -0.4 0.5
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.3 0.6 -0.4 0.5 -0.3
Illnesses of siblings: Diabetes 1.0 1.3 3.9 0.6 2.0 1.2 -0.2 0.8
Smoking status: Previous 1.6 2.4 4.9 -0.9 1.2 0.8 2.2 2.1
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 8.8 3.0 -1.7 -1.1 -1.8 -1.5
Whole body fat-free mass 1.0 6.0 8.5 2.5 -2.9 -1.4 2.6 2.4
Leg fat-free mass (right) 0.8 4.3 6.2 1.9 -2.3 -0.9 2.5 2.3
Arm fat percentage (left) 1.4 5.4 14.7 -3.8 1.6 1.4 2.2 1.7
Average weekly red wine intake 0.4 0.6 1.4 -1.2 -0.4 -0.9 0.7 0.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.3 -0.8 -0.5 0.3 0.1
Mood swings 0.8 1.5 2.5 -1.1 1.4 -0.8 1.6 1.0
Loneliness, isolation 1.5 2.0 3.0 0.2 1.7 -1.6 -1.4 -1.7
Long-standing illness, disability or infirmity 1.6 2.5 4.1 -2.0 1.8 1.2 1.2 1.4
Ever had bowel cancer screening 1.5 1.7 3.7 -1.6 1.2 1.9 -1.0 -0.3
Diabetes diagnosed by doctor 1.9 3.0 6.7 -2.6 1.3 -0.3 2.3 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 0.2 -0.2 -0.4 0.5 0.3
Friendships satisfaction 0.9 1.1 2.7 1.5 0.6 -0.1 -1.7 -0.1
Qualifications: nursing, teaching 0.4 0.6 1.1 0.5 -1.0 0.1 -0.9 -0.8
Commuting to job workplace: Walk 3.5 3.8 8.6 0.1 -1.6 -2.5 -1.3 -2.9
Eye problems/disorders: Cataract 1.3 1.5 5.1 2.3 1.1 -1.1 -0.1 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 -0.3 0.6 -1.0 -0.6 -0.9
Medication for cholesterol 1.0 1.5 3.7 1.3 -0.5 -0.5 -1.4 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.6 1.2 -0.7 -0.8 -0.5 -0.6
Back pain experienced in last month 0.2 0.4 1.1 -0.7 1.0 -0.3 0.1 -0.3
Mineral and other dietary supplements 0.3 0.4 0.7 0.1 0.7 0.8 -0.8 -0.1
Breast cancer (self-reported) 2.8 3.4 12.4 -3.5 1.1 1.3 1.1 0.3
Asthma (self-reported) 0.8 1.6 6.5 -2.5 0.4 0.8 -0.7 -0.4
Osteoporosis (self-reported) 0.3 0.4 1.0 -0.4 0.6 -0.1 1.0 0.7
Osteoarthritis (self-reported) 0.9 1.2 3.4 -1.4 1.8 0.5 0.5 0.0
Medication: Aspirin 3.2 4.1 7.0 -2.2 2.1 0.3 2.7 2.1
Medication: Gliclazide 1.5 1.7 4.1 -2.0 -0.0 -0.3 1.7 1.2
Illnesses of father: None of the above (group 1) 0.3 0.3 1.4 -1.2 0.1 0.2 0.3 0.4
Smoking status: Current 1.2 1.9 4.9 -2.2 1.5 0.9 1.1 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.0 0.2 1.4 1.4 -0.9 -0.3
Whole body water mass 1.0 5.7 8.3 2.4 -2.9 -1.3 2.6 2.5
Leg predicted mass (right) 0.8 4.3 6.1 1.9 -2.4 -0.9 2.5 2.3
Arm fat mass (left) 1.1 4.3 7.7 -2.8 0.3 0.8 2.8 2.4
Number of self-reported non-cancer illnesses 1.8 3.0 8.2 -2.9 2.1 1.2 0.3 1.0
Average weekly champagne plus white wine intake 0.4 0.6 2.1 -1.5 -0.8 0.4 -0.2 0.0
Miserableness 0.4 0.7 2.3 0.0 0.9 -1.5 0.6 0.0
Guilty feelings 0.8 1.2 1.4 1.0 -1.1 -1.0 -1.2 -1.2
Wears glasses or contact lenses 0.3 0.4 0.8 -0.5 -0.6 0.2 0.9 0.7
Ever taken oral contraceptive pill 0.6 0.6 1.3 -0.6 0.8 0.8 0.6 1.1
Hearing aid user 0.6 0.7 2.2 -1.5 -0.1 0.5 0.8 0.8
Mother’s age at death 0.2 0.2 0.4 -0.5 0.2 -0.7 0.2 0.6
Financial situation satisfaction 0.3 0.4 1.1 -0.5 1.1 0.3 0.3 0.7
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.0 0.8 1.4 1.4 -0.3 0.3
Commuting to job workplace: Public transport 2.7 3.3 6.0 -1.4 2.5 -0.9 -1.5 -2.3
Eye problems/disorders: Glaucoma 1.8 2.1 8.5 -0.7 -0.8 -2.9 0.8 -0.5
Medication: Blood pressure 0.1 0.1 0.3 0.5 -0.5 -0.0 -0.0 0.4
Pain type(s) experienced in last month: Hip pain 2.0 2.5 4.4 -1.5 1.4 0.7 2.1 1.7
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.6 0.5 -0.2 0.7 0.1 0.1
High cholesterol (Self-reported) 0.7 1.2 2.6 -1.2 1.3 -1.6 0.6 -0.3
Medication: Bendroflumethiazide 1.5 2.3 6.5 2.5 -1.3 -1.4 -1.1 -0.6
Medication: Paracetamol 2.9 4.4 6.7 -2.4 2.6 2.4 0.7 1.9
Medication: Lisinopril 1.7 2.2 5.8 2.3 -2.4 0.1 0.0 0.4
Medication: Atorvastatin 1.3 1.7 4.9 -2.2 -0.1 -1.6 0.9 -0.5
Illnesses of father: High blood pressure 2.2 2.7 9.2 3.0 -1.7 -0.8 -0.6 -0.5
Alcohol drinker status: Never 2.9 3.5 7.1 -1.4 2.7 1.6 -2.0 -1.2
Ever smoked 0.8 1.5 3.3 -1.0 0.3 0.5 1.8 1.6
Basal metabolic rate 0.8 4.6 6.8 1.8 -2.6 -1.0 2.6 2.3
Leg fat percentage (left) 0.9 3.2 10.7 -3.3 1.2 1.3 1.3 0.6
Arm fat-free mass (left) 0.9 4.4 7.3 1.4 -2.5 -0.9 2.7 2.4
Number of operations (self-reported) 2.0 3.0 8.3 -1.5 2.9 1.3 -1.2 -1.0
Average weekly beer plus cider intake 0.7 1.0 3.4 1.9 -0.5 -0.2 -0.4 1.0
Irritability 0.6 1.1 2.0 -1.1 0.2 -0.5 1.4 1.4
Risk taking 0.4 0.5 1.8 0.6 -0.0 -1.3 0.1 -0.7
Ever had prostate specific antigen (PSA) test 2.6 3.0 7.3 0.8 -0.4 -0.0 -2.7 -2.6
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.3 -0.5 0.6 -0.9 -0.9
Age started oral contraceptive pill 1.4 1.7 3.5 0.5 0.8 -1.1 -1.8 -1.9
Diastolic blood pressure, automated reading 0.2 0.6 2.4 0.7 -1.6 0.3 0.0 -0.4
Ever depressed for a whole week 1.7 2.1 8.1 -0.7 2.8 1.3 0.0 0.5
Unable to work because of sickness or disability 1.0 1.3 4.2 0.6 2.0 -1.3 0.5 0.3
Commuting to job workplace: Cycle 0.9 1.1 2.1 1.0 -1.4 -1.4 0.3 0.3
Myopia 0.6 0.8 3.5 -0.7 0.1 -1.9 0.4 -0.2
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 -0.5 -0.4 -1.0 -0.1 -0.9
Cholesterol lowering medication 0.5 0.7 3.2 -1.8 -0.1 -0.1 0.3 0.4
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.4 -0.8 1.0 0.9 -1.2 -0.3
Pain experienced in last month 0.4 0.7 1.0 0.8 -0.6 -0.9 -0.8 -1.0
Supplements: Calcium 0.3 0.3 0.4 -0.5 -0.5 0.6 0.5 0.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 1.1 0.7 -0.4 -0.2 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.2 -0.2 0.8 1.5 -1.1 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.4 -0.8 1.5 0.9 0.9 1.5
Heart disease (siblings) 0.6 0.8 2.7 0.5 0.9 -1.6 -0.1 -0.5
Alcohol drinker status: Previous 0.7 0.8 2.1 -0.9 1.4 0.8 0.3 0.7
Pack years of smoking 1.5 2.2 4.4 -2.1 2.1 0.2 1.3 0.6
Impedance of whole body 0.6 2.9 8.1 0.6 -0.4 -0.0 -2.8 -2.4
Leg fat mass (left) 0.5 2.0 3.9 -2.0 0.2 0.8 1.9 1.4
Arm predicted mass (left) 0.9 4.8 7.6 1.7 -2.7 -1.1 2.8 2.3