Hub : Genes

SPTB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.055	0.0200	0.00012	0.053	0.049	0.047	0.05	0.049	4.4e-07	1.1e-06	2.1e-06	9.5e-07	1.3e-06
2	GTEx	Artery Aorta	0.134	0.0530	0.00610	-0.003	NA	0.010	NA	0.000	5.0e-01	NA	9.0e-02	NA	3.2e-01
3	GTEx	Artery Tibial	0.140	0.0399	0.00010	0.068	NA	0.041	NA	0.046	4.8e-06	NA	3.3e-04	NA	1.6e-04
4	GTEx	Pancreas	0.287	0.0820	0.00017	0.217	NA	0.206	NA	0.235	1.5e-09	NA	4.2e-09	NA	2.6e-10
5	GTEx	Skin Sun Exposed Lower leg	0.122	0.0480	0.00220	0.020	NA	0.009	NA	0.028	8.6e-03	NA	5.3e-02	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	1.5	-1.2	-0.3	-1.1	0.9	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.1	1.9	-1.3	-0.3	-1.2	-0.0	-1.4
Depressed Affect (Nagel 2018)	0.5	1.1	3.0	0.1	1.7	-1.3	-0.5	-0.8
Depression (Nagel 2018)	0.1	0.1	0.4	-0.2	-0.2	0.0	-0.2	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.7	5.3	-1.7	2.3	0.1	-0.2	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.9	-0.1	1.4	-1.1	-0.3	-0.5
Schizophrenia (2018)	0.4	0.9	3.0	-0.7	-0.2	-0.7	-0.8	-1.7
Schizophrenia vs Biploar Disorder	1.0	1.3	3.9	0.8	-0.0	0.6	-2.0	-1.4
Worry (Nagel 2018)	0.0	0.1	0.3	0.0	0.2	-0.5	0.1	0.4
Alzheimer’s Disease (in mother)	1.6	1.8	3.6	-1.0	-0.7	1.9	1.1	1.7
Alzheimer’s Disease (in father)	3.1	3.4	7.3	-2.7	0.4	-0.1	2.6	1.7
Alzheimer’s Disease (including proxy)	1.8	2.6	4.5	-2.1	-0.4	1.4	1.9	1.7
Crohns Disease (2017)	0.2	0.4	0.6	-0.3	0.8	0.6	0.8	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-1.1	0.7	-0.1	0.9	0.2
Ulcerative Colitis (UC)	0.3	0.6	2.5	-1.6	0.6	0.2	0.5	0.1
Major Depression (MDD)	0.7	0.9	2.4	-1.5	0.5	1.2	0.1	0.6
Reaction Time	1.1	2.2	4.0	-0.6	2.0	1.8	0.8	1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.0	5.4	-2.1	2.3	-0.2	0.4	0.2
Breast Cancer	0.8	2.0	5.5	0.8	-1.8	-2.4	0.7	-0.1
Ovarian Cancer	0.4	0.5	1.5	-0.8	-1.2	0.0	0.4	0.4
Prostate Cancer	0.8	1.1	3.4	-1.8	0.5	-0.7	1.1	0.6
Age at First Birth	0.9	1.4	2.6	0.8	-1.6	0.2	-1.6	-1.0
Bipolar Disorder (2011)	1.6	1.5	3.5	0.7	-0.6	-1.3	-1.3	-1.9
Body Mass Index (BMI) (2010)	0.6	0.8	3.2	-0.7	1.8	0.3	0.3	0.1
Coronary Artery Disease (CAD)	0.9	1.1	2.6	0.6	1.6	0.8	-1.2	-0.5
Crohns Disease (2012)	0.4	0.7	1.8	-0.3	1.3	0.2	1.1	0.5
Mean Putamen Volume	1.0	1.1	2.6	-1.6	0.5	1.5	-0.4	0.7
Fasting Glucose	0.7	0.8	1.7	-0.8	0.7	1.3	0.2	1.0
HbA1C	1.2	1.4	2.5	-0.9	1.0	0.6	1.6	1.4
HDL Cholesterol	0.1	0.2	0.7	-0.4	0.8	0.3	-0.4	0.1
LDL Cholesterol	0.5	0.7	2.2	0.0	0.3	-1.5	1.1	-0.1
Lupus	0.8	1.3	2.4	-1.2	-1.0	-0.6	1.6	1.1
Neuroticism (2016)	0.3	0.4	0.8	0.9	-0.2	0.5	0.0	0.9
Primary Biliary Cirrhosis	1.1	1.5	3.0	-0.5	1.7	1.7	-0.9	-0.9
Rheumatoid Arthritis	0.7	0.9	2.9	1.7	-0.0	-1.1	-0.1	-0.6
Schizophrenia (2014)	0.6	1.2	3.2	-1.0	0.7	-0.5	-1.1	-1.8
Triglycerides	0.4	0.7	1.3	0.1	-1.1	0.6	0.8	1.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.9	-1.2	1.6	1.7	0.5	0.1
Ulcerative Colitis	0.3	0.4	1.1	-1.0	0.8	0.3	0.1	-0.4
Blood Eosinophil Count	1.6	12.4	26.7	-5.2	4.1	4.3	0.2	0.7
Blood Platelet Count	1.3	15.0	33.4	-5.7	5.8	2.1	-0.1	-2.2
Blood Red Count	1.4	13.8	51.9	7.2	-3.5	-2.2	-0.2	-0.0
Blood White Count	0.7	5.1	11.5	-2.4	2.3	3.4	1.0	1.3
Heel T-Score	0.4	2.8	8.4	-2.9	0.7	1.9	0.7	1.1
BMI	1.8	10.5	23.5	-4.8	1.9	0.5	4.3	2.6
Height	1.9	36.5	72.9	8.5	-8.2	-6.5	-0.7	-0.8
Waist Hip Ratio (WHR)	1.1	4.8	9.7	-3.0	0.1	3.1	0.7	2.2
Systolic Blood Pressure	0.8	3.8	10.5	2.7	-3.2	-0.8	-0.4	-0.3
Smoking Status	1.6	3.9	6.3	-2.5	1.8	1.2	2.2	2.0
Allergy or Eczema	0.7	1.8	4.6	-1.2	2.1	1.6	-0.3	0.6
Cardiovascular Disease	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.3	0.3
Hypothyroidism (self reported)	0.3	0.6	1.7	-0.4	0.1	-1.3	-0.7	-0.8
Respiratory disease	1.0	2.2	8.1	-2.8	0.8	1.5	-0.5	0.2
Type 2 Diabetes (T2D) (2018)	1.6	3.0	6.9	-2.6	1.6	-0.7	2.0	0.9
Lung FEV1/FVC ratio	0.1	0.4	1.6	0.2	1.3	0.0	0.3	-0.4
Lung FVC	0.3	1.3	4.6	-0.1	2.2	0.8	-0.9	-0.6
Neuroticism	0.4	0.9	2.4	0.1	1.3	-1.5	-0.4	-0.5
Chronotype (morning person)	0.4	0.9	4.0	0.5	-2.0	-0.6	-0.1	-0.2
Hair Pigment	0.2	6.0	9.7	-2.3	2.1	1.0	3.1	3.1
Tanning	0.1	1.5	3.7	-0.9	0.8	-1.3	-1.0	-1.9
Hand grip strength (left)	1.1	2.8	5.4	2.2	-2.3	-1.8	0.2	-0.7
Number of treatments/medications taken	2.7	4.9	8.5	-2.4	1.5	0.5	2.9	2.8
Average weekly spirits intake	2.3	2.9	5.2	-0.8	1.6	2.0	1.5	2.3
Sensitivity / hurt feelings	1.3	2.3	4.6	-1.6	2.1	-1.7	1.1	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-1.1	0.7	-1.0	0.7	0.6
Hearing difficulty/problems: Yes	0.8	1.2	4.0	0.7	-0.3	0.6	-2.0	-1.1
Relative age of first facial hair	0.8	1.6	4.7	-0.4	2.2	0.1	-1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.9	-1.3	1.7	0.8	1.1	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.7	-1.6	-0.3	-0.2	-0.4	-0.5
Ever had hysterectomy (womb removed)	0.4	0.4	1.1	0.0	0.8	0.6	-1.0	0.4
Systolic blood pressure, automated reading	0.2	0.6	1.2	0.9	-1.1	0.4	0.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.2	-0.3	1.1	-0.1	-0.0	-0.3
Angina	0.3	0.3	1.4	-0.1	-0.2	1.2	0.0	0.5
Medication for hormone replacement therapy	1.7	1.9	3.6	-1.7	1.9	1.0	0.7	1.3
Vitamin and mineral supplements	2.0	2.8	7.2	2.7	-1.0	-0.1	-1.9	-1.4
Supplements: Zinc	0.1	0.1	0.3	-0.5	-0.4	0.3	-0.4	0.2
Medication: Co-codamol	1.4	1.6	3.3	-1.6	0.6	-1.8	1.3	0.5
Medication: Metformin	1.0	1.4	3.4	-1.0	0.8	-1.2	1.8	0.8
Diabetes (father)	1.2	1.5	2.4	1.6	-1.4	0.9	-0.1	1.4
Diabetes (mother)	0.7	0.9	2.5	0.3	-0.9	-1.6	-0.3	-0.9
Severe depression (siblings)	1.0	1.1	2.7	-1.6	1.6	-0.2	-0.3	-0.5
Pack years adult smoking proportion	1.9	2.9	5.8	-2.3	2.4	0.4	1.6	0.8
Impedance of leg (right)	0.6	2.8	7.2	0.5	-0.4	-0.3	-2.7	-2.6
Leg fat-free mass (left)	0.8	4.1	6.2	1.7	-2.2	-0.9	2.5	2.4
Trunk fat percentage	0.8	3.1	8.2	-2.9	0.8	1.5	1.5	1.3
Hand grip strength (right)	1.2	3.1	5.8	1.7	-2.4	-2.1	1.5	0.5
Townsend deprivation index at recruitment	1.5	2.1	4.7	-2.1	2.2	-0.6	0.7	-0.4
Current tobacco smoking	1.1	1.9	5.0	-2.2	1.3	1.0	1.0	0.8
Average weekly fortified wine intake	1.7	2.0	6.5	1.0	0.7	2.5	-0.6	1.4
Maternal smoking around birth	1.3	1.9	5.2	-2.3	1.1	-0.0	1.7	0.4
Fed-up feelings	1.1	2.0	3.6	-1.6	1.9	-1.4	1.3	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-0.7	0.7	-0.3	0.5	1.0
Relative age voice broke	0.4	0.6	1.8	0.6	1.3	-0.6	-0.2	-0.7
Taking other prescription medications	3.4	5.2	9.0	-3.0	2.7	0.9	1.9	2.3
Age when periods started (menarche)	0.8	1.9	7.4	-2.7	0.2	-0.9	0.8	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.8	-0.5	-0.2	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.0	-0.6	-0.0	-1.0	2.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.4	-0.7	0.3	-0.8	-0.0
Qualifications: CSEs or equivalent	0.7	0.9	2.6	-1.0	1.6	-0.4	-0.2	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.4	-0.0	-0.0	-0.8	-0.4
High blood pressure	0.1	0.4	0.7	0.8	-0.1	0.7	0.2	0.8
Hayfever, allergic rhinitis or eczema	0.8	1.6	4.1	-2.0	1.9	0.5	-0.5	-0.2
Multivitamins +/- minerals	0.8	1.0	4.6	-2.1	-0.1	0.0	0.5	0.2
Stomach or abdominal pain in last month	2.1	2.6	5.7	-2.4	1.7	0.7	1.5	1.3
Supplements: Glucosamine	0.7	1.0	2.5	-1.6	0.0	-1.1	1.0	0.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.7	5.2	-2.1	2.3	1.7	0.3	0.7
Medication: Atenolol	0.3	0.4	0.7	0.8	-0.4	-0.7	-0.6	0.1
Medication: Levothyroxine sodium	0.3	0.5	1.6	-0.7	-1.3	-0.3	0.4	0.6
Sitting height	1.4	10.2	25.7	5.1	-4.4	-2.3	-0.7	-0.0
Chronic bronchitis/emphysema (father)	1.1	1.3	2.4	1.5	1.0	-0.6	-0.9	-1.5
High blood pressure (mother)	0.1	0.2	0.6	-0.2	0.8	0.2	0.3	0.4
Body mass index (BMI)	1.4	6.0	13.0	-3.6	1.5	1.3	2.9	2.2
Impedance of leg (left)	0.6	2.8	6.7	0.3	-0.5	-0.2	-2.6	-2.6
Leg predicted mass (left)	0.8	4.1	6.4	1.6	-2.2	-0.9	2.5	2.4
Trunk fat mass	0.5	2.1	3.7	-1.8	-0.0	0.8	1.9	1.7
Waist circumference	0.9	3.1	6.3	-2.5	0.0	0.6	2.3	2.0
Number of incorrect matches in round	0.4	0.6	1.8	-0.3	0.8	1.3	0.5	0.6
Past tobacco smoking	1.6	3.0	5.0	1.7	-1.2	-0.9	-2.2	-2.2
Alcohol usually taken with meals	0.3	0.4	0.8	-0.7	-0.8	-0.1	-0.4	-0.9
Nervous feelings	1.0	2.0	4.9	-0.6	-0.7	-2.2	-1.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.2	-1.5	0.9	-0.7	-0.1	-0.1
Hearing difficulty/problems with background noise	0.5	0.8	2.4	-0.3	1.6	0.8	-0.7	-0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.5	-0.4	0.7	0.4	0.2
Had menopause	0.3	0.3	1.3	0.3	1.1	-0.3	-0.3	-0.2
Had other major operations	0.1	0.2	0.5	-0.5	0.7	-0.2	0.1	-0.1
Forced vital capacity (FVC)	0.4	1.4	4.7	2.2	-1.1	0.2	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.2	-1.3	-0.5	-1.6	1.8	0.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.6	0.2	1.8	-0.3	-2.1	-1.6
Qualifications: None of the above	0.0	0.1	0.2	0.5	0.2	0.4	0.3	0.1
Financial difficulties in last 2 years	1.9	2.6	9.7	-3.1	1.5	0.7	0.0	-0.6
Mouth/teeth dental problems	1.3	2.0	4.9	2.2	-0.3	0.8	-1.8	-1.0
Heart attack	0.6	0.8	2.1	-0.0	0.7	1.4	-1.2	-0.3
Allergy	1.2	2.7	8.1	2.9	-1.9	-1.2	0.1	-0.4
Pain all over the body in last month	2.4	2.6	7.3	2.7	-0.6	-0.1	-2.1	-0.9
Diabetes (self-reported)	1.7	2.6	5.1	-2.3	2.0	-0.1	1.7	1.0
Hayfever/allergic rhinitis (self-reported)	2.8	3.8	9.3	-3.0	3.0	0.5	0.7	0.1
Medication: Ramipril	0.9	1.1	2.9	0.9	-0.7	-1.7	-0.5	-1.1
Medication: Simvastatin	0.4	0.6	1.3	-0.3	1.1	-0.3	0.9	0.8
Fluid intelligence score	1.0	2.1	4.6	-0.4	2.1	-2.1	1.1	-0.5
Illnesses of siblings	0.4	0.5	2.0	-1.4	-0.3	-0.4	0.4	-0.4
Neuroticism score	0.6	1.3	3.4	-0.4	1.6	-1.9	-0.0	-0.4
Weight	0.5	2.2	5.3	-0.4	-1.4	-0.2	2.3	1.9
Impedance of arm (right)	0.3	1.6	4.7	0.5	-0.6	-0.5	-2.2	-1.6
Arm fat percentage (right)	1.3	5.2	14.4	-3.8	1.3	1.2	2.3	1.8
Trunk fat-free mass	1.2	6.9	11.3	2.9	-3.4	-1.7	2.6	2.3
Hip circumference	0.2	0.9	2.7	-0.7	-0.2	-0.7	1.6	0.9
Time employed in main current job	0.8	0.9	2.1	-0.1	-0.8	-1.5	1.3	0.1
Alcohol intake versus 10 years previously	0.8	1.2	2.3	-1.5	-1.5	0.5	0.9	0.6
Father’s age at death	0.8	1.0	2.6	-0.2	-1.6	-1.4	-0.4	-0.6
Worrier / anxious feelings	0.6	1.1	3.1	0.3	1.2	-0.0	-1.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.2	-0.8	2.3	-0.1	-0.1	0.7
Falls in the last year	1.6	2.2	4.2	-1.6	0.6	-1.7	-0.9	-2.0
Hair/balding pattern: Pattern 3	1.1	1.7	4.3	-0.0	0.9	1.4	1.2	2.1
Number of live births	0.7	1.0	2.5	1.3	0.6	0.6	-0.3	1.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.1	2.0	-0.3	0.4	0.4	1.0
Pulse rate	0.4	0.6	2.0	0.5	1.4	0.5	-0.6	-0.4
Happiness	2.3	2.7	5.9	1.3	0.5	-1.5	-2.4	-1.9
Noisy workplace	1.8	2.3	3.5	-1.7	0.7	1.5	1.5	1.9
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	1.0	0.5	0.1	-0.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.1	-0.2	-0.2	1.6	0.4	1.8
Mouth/teeth dental problems: Dentures	0.7	1.2	2.2	-1.5	0.5	-1.1	1.4	0.6
Asthma	0.8	1.6	5.7	-2.4	0.4	0.9	-0.9	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.4	-1.5	0.9	0.7	1.1	0.4
Medication: Cholesterol lowering	0.4	0.7	1.7	-0.6	1.3	0.1	0.9	0.6
Depression (self-reported)	0.3	0.4	1.2	-0.5	-0.2	-1.1	0.5	-0.3
Medication: Lansoprazole	1.5	1.7	4.0	-0.9	0.6	0.3	1.8	2.0
Prospective memory result	0.8	0.9	2.8	0.6	-0.5	1.7	-1.1	0.3
Lung cancer (father)	0.3	0.3	0.9	1.0	0.1	-0.5	0.2	-0.5
Illnesses of mother	1.7	2.1	5.1	1.5	-0.4	-2.2	-0.1	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.5	1.9	-0.1	0.6	-0.2	0.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.5	0.9	-1.6	0.7	0.1	0.3
Impedance of arm (left)	0.5	2.3	6.5	0.8	-0.2	-0.4	-2.6	-2.0
Arm fat mass (right)	0.9	3.7	6.9	-2.6	0.1	0.7	2.6	2.1
Trunk predicted mass	1.2	7.0	11.9	2.9	-3.5	-1.8	2.6	2.3
Standing height	2.0	19.5	44.7	6.6	-6.7	-2.9	-0.8	0.1
Length of working week for main job	0.4	0.4	1.2	-0.6	-1.1	0.7	0.3	0.1
Exposure to tobacco smoke at home	1.6	1.8	6.3	-1.0	2.5	1.2	-0.1	0.5
Breastfed as a baby	1.6	2.0	7.5	-2.7	1.3	-0.2	0.7	0.4
Tense / ‘highly strung’	0.7	1.2	2.5	-1.2	0.7	-0.8	1.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	8.8	-3.0	2.0	1.0	0.8	0.6
Hair/balding pattern: Pattern 4	0.8	2.0	7.2	1.0	-1.1	-2.7	0.3	-0.9
Birth weight of first child	0.5	1.0	1.7	1.3	-1.0	1.1	0.0	1.0
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.5	-0.2	-0.2	1.1	0.9
Pulse wave reflection index	0.5	0.6	2.5	-1.6	-0.5	0.4	0.4	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.3	-0.4	0.1	0.7	0.7
Loud music exposure frequency	2.1	2.2	4.8	-1.7	-0.3	-0.1	2.2	1.9
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.2	0.4	0.5	-0.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.0	-1.0	-0.4	-0.8	0.9	0.2
Blood clot in the leg (DVT)	0.9	1.1	2.1	-0.7	1.5	0.9	0.8	1.4
Medication: Paracetamol	3.9	6.4	9.9	-3.1	2.9	2.5	1.4	2.4
Headache pain in last month	0.3	0.6	1.0	-0.9	0.7	0.3	0.8	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.9	-0.3	1.0	-0.6	0.5
Glaucoma (self-reported)	2.1	2.4	10.1	0.3	-0.1	-3.2	-0.0	-1.4
Gout (self-reported)	0.7	1.0	2.3	0.7	-1.5	0.3	1.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.9	-1.0	-0.1	-0.6	0.1	0.1
Medication: Amlodipine	1.0	1.4	3.4	0.9	-1.5	-1.9	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-1.1	-0.6	-0.2	0.9	0.2
Birth weight	1.3	2.9	5.4	2.0	0.6	2.3	-2.1	-0.3
Chronic bronchitis/emphysema (mother)	2.9	3.3	7.8	-2.3	2.8	1.7	0.2	0.8
High blood pressure (siblings)	1.1	1.5	3.8	1.0	-1.0	1.9	0.1	1.4
Forced vital capacity (FVC), Best measure	0.3	1.0	3.3	1.8	-0.8	0.4	-0.3	1.0
Body fat percentage	0.9	3.7	10.7	-3.3	1.3	1.6	1.5	1.1
Leg fat percentage (right)	0.8	2.8	9.5	-3.1	1.2	1.1	1.2	0.5
Arm fat-free mass (right)	0.8	4.0	6.3	1.7	-2.1	-0.7	2.5	2.4
Exposure to tobacco smoke outside home	0.3	0.5	1.0	-0.1	0.9	-0.2	1.0	0.7
Comparative body size at age 10	0.2	0.4	1.0	-0.4	-0.3	-1.0	0.9	0.5
Number of full brothers	0.4	0.5	2.2	-0.0	1.5	-0.4	-0.6	0.0
Worry too long after embarrassment	0.3	0.5	0.6	0.8	0.7	-0.8	-0.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	0.5	0.5	-0.5	-0.4
Wheeze or whistling in the chest in last year	1.0	1.9	5.2	-2.3	1.8	-0.2	0.6	-0.6
Number of children fathered	0.7	0.8	2.1	-0.5	0.9	1.4	0.5	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	6.0	-0.1	-2.4	1.0	-0.3	0.8
Age at first live birth	0.6	1.1	3.0	1.0	-1.7	-0.4	-0.8	-0.8
Pulse wave peak to peak time	0.4	0.5	1.1	-0.2	1.1	-1.0	-0.2	-0.3
Health satisfaction	0.8	1.1	1.9	1.4	1.2	0.7	-1.2	0.3
Shortness of breath walking on level ground	0.7	0.8	1.7	-0.1	0.7	0.4	1.3	1.2
Qualifications: College or University degree	1.2	3.7	10.1	0.4	0.5	-2.2	-1.7	-3.2
Eye problems/disorders: None of the above	0.8	0.9	2.3	-1.1	-0.7	1.5	-0.1	0.5
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.7	0.8	0.1	-1.3	-1.0	-1.3
Emphysema/chronic bronchitis	3.7	4.2	12.1	-3.5	1.1	0.9	1.7	2.0
Medication for pain relief, constipation, heartburn	3.8	6.5	13.5	3.7	-3.1	-1.6	-2.0	-1.7
Neck or shoulder pain in last month	0.9	1.2	4.9	-0.5	2.2	0.0	0.8	0.4
Medication: Blood pressure	0.5	0.8	3.0	1.7	-0.4	-0.9	0.3	-0.2
Angina (self-reported)	0.3	0.4	1.3	0.1	-0.2	1.1	0.3	0.6
Migraine (self-reported)	0.7	0.8	2.3	-1.5	0.4	-0.4	1.1	0.5
Medication: Ibuprofen	0.4	0.5	1.2	-1.1	0.3	0.6	0.8	0.3
Medication: Allopurinol	1.2	1.6	4.4	1.6	-2.1	0.0	-0.6	-0.7
Medication: Omeprazole	0.3	0.4	1.3	-1.2	0.5	0.3	-0.3	-0.5
Medication: Seretide 50 evohaler	1.1	1.2	3.9	-0.2	0.6	-0.1	-1.4	-2.0
Mean time to correctly identify matches	0.9	1.7	3.2	-0.7	1.8	1.6	0.7	1.3
Heart disease (mother)	0.6	0.7	1.7	1.3	-0.4	0.1	-1.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	4.2	-2.0	0.2	-0.3	-0.4	-1.0
Whole body fat mass	0.5	2.2	4.0	-2.0	0.1	0.8	2.0	1.6
Leg fat mass (right)	0.5	2.0	3.8	-1.9	0.2	0.8	1.9	1.5
Arm predicted mass (right)	0.8	3.9	5.4	2.3	-2.3	-0.8	2.1	2.0
Pulse rate, automated reading	0.7	2.2	3.2	-1.5	1.8	1.5	-1.7	-0.8
Alcohol intake frequency.	0.3	0.7	1.8	-0.2	-0.4	1.2	-1.3	-0.4
Comparative height size at age 10	1.5	8.5	20.3	4.5	-4.4	-1.6	0.1	0.8
Number of full sisters	2.4	2.9	6.0	-1.5	-0.0	0.4	2.4	2.4
Suffer from ‘nerves’	0.7	1.1	2.1	-1.5	-0.7	-1.1	1.3	0.4
Overall health rating	1.8	3.9	7.8	-2.8	2.5	0.6	1.5	1.7
Chest pain or discomfort	1.2	1.7	4.2	-2.0	1.6	1.2	-0.2	-0.5
Had major operations	1.9	2.2	8.2	-1.6	2.9	-0.0	0.4	-0.3
Age at last live birth	0.3	0.4	1.1	1.1	-0.4	-0.1	-0.9	-0.3
Family relationship satisfaction	0.9	1.1	3.0	0.9	1.7	-0.3	-1.3	0.3
Leg pain on walking	0.2	0.2	0.6	0.4	0.8	-0.0	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.2	-0.4	0.9	2.0	-0.1	1.1
Commuting to job workplace: Car/motor vehicle	1.9	2.1	6.0	0.6	-0.4	0.8	1.9	2.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.6	0.1	-0.9	0.5	-0.5
Medication: Aspirin	2.8	3.7	5.9	-2.4	2.1	0.2	2.3	1.7
Supplements: Vitamin C	3.4	4.0	7.1	-2.7	1.7	1.4	1.9	2.0
Knee pain experienced in last month	3.2	5.0	11.0	-3.3	2.8	1.5	1.6	1.2
Hypertension (Self-reported)	0.1	0.3	0.7	0.8	-0.1	0.5	0.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.7	-0.6	0.8	-0.4	0.5
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.3	0.6	-0.4	0.5	-0.3
Illnesses of siblings: Diabetes	1.0	1.3	3.9	0.6	2.0	1.2	-0.2	0.8
Smoking status: Previous	1.6	2.4	4.9	-0.9	1.2	0.8	2.2	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	8.8	3.0	-1.7	-1.1	-1.8	-1.5
Whole body fat-free mass	1.0	6.0	8.5	2.5	-2.9	-1.4	2.6	2.4
Leg fat-free mass (right)	0.8	4.3	6.2	1.9	-2.3	-0.9	2.5	2.3
Arm fat percentage (left)	1.4	5.4	14.7	-3.8	1.6	1.4	2.2	1.7
Average weekly red wine intake	0.4	0.6	1.4	-1.2	-0.4	-0.9	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.3	-0.8	-0.5	0.3	0.1
Mood swings	0.8	1.5	2.5	-1.1	1.4	-0.8	1.6	1.0
Loneliness, isolation	1.5	2.0	3.0	0.2	1.7	-1.6	-1.4	-1.7
Long-standing illness, disability or infirmity	1.6	2.5	4.1	-2.0	1.8	1.2	1.2	1.4
Ever had bowel cancer screening	1.5	1.7	3.7	-1.6	1.2	1.9	-1.0	-0.3
Diabetes diagnosed by doctor	1.9	3.0	6.7	-2.6	1.3	-0.3	2.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.2	-0.2	-0.4	0.5	0.3
Friendships satisfaction	0.9	1.1	2.7	1.5	0.6	-0.1	-1.7	-0.1
Qualifications: nursing, teaching	0.4	0.6	1.1	0.5	-1.0	0.1	-0.9	-0.8
Commuting to job workplace: Walk	3.5	3.8	8.6	0.1	-1.6	-2.5	-1.3	-2.9
Eye problems/disorders: Cataract	1.3	1.5	5.1	2.3	1.1	-1.1	-0.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.3	0.6	-1.0	-0.6	-0.9
Medication for cholesterol	1.0	1.5	3.7	1.3	-0.5	-0.5	-1.4	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	1.2	-0.7	-0.8	-0.5	-0.6
Back pain experienced in last month	0.2	0.4	1.1	-0.7	1.0	-0.3	0.1	-0.3
Mineral and other dietary supplements	0.3	0.4	0.7	0.1	0.7	0.8	-0.8	-0.1
Breast cancer (self-reported)	2.8	3.4	12.4	-3.5	1.1	1.3	1.1	0.3
Asthma (self-reported)	0.8	1.6	6.5	-2.5	0.4	0.8	-0.7	-0.4
Osteoporosis (self-reported)	0.3	0.4	1.0	-0.4	0.6	-0.1	1.0	0.7
Osteoarthritis (self-reported)	0.9	1.2	3.4	-1.4	1.8	0.5	0.5	0.0
Medication: Aspirin	3.2	4.1	7.0	-2.2	2.1	0.3	2.7	2.1
Medication: Gliclazide	1.5	1.7	4.1	-2.0	-0.0	-0.3	1.7	1.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.4	-1.2	0.1	0.2	0.3	0.4
Smoking status: Current	1.2	1.9	4.9	-2.2	1.5	0.9	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.0	0.2	1.4	1.4	-0.9	-0.3
Whole body water mass	1.0	5.7	8.3	2.4	-2.9	-1.3	2.6	2.5
Leg predicted mass (right)	0.8	4.3	6.1	1.9	-2.4	-0.9	2.5	2.3
Arm fat mass (left)	1.1	4.3	7.7	-2.8	0.3	0.8	2.8	2.4
Number of self-reported non-cancer illnesses	1.8	3.0	8.2	-2.9	2.1	1.2	0.3	1.0
Average weekly champagne plus white wine intake	0.4	0.6	2.1	-1.5	-0.8	0.4	-0.2	0.0
Miserableness	0.4	0.7	2.3	0.0	0.9	-1.5	0.6	0.0
Guilty feelings	0.8	1.2	1.4	1.0	-1.1	-1.0	-1.2	-1.2
Wears glasses or contact lenses	0.3	0.4	0.8	-0.5	-0.6	0.2	0.9	0.7
Ever taken oral contraceptive pill	0.6	0.6	1.3	-0.6	0.8	0.8	0.6	1.1
Hearing aid user	0.6	0.7	2.2	-1.5	-0.1	0.5	0.8	0.8
Mother’s age at death	0.2	0.2	0.4	-0.5	0.2	-0.7	0.2	0.6
Financial situation satisfaction	0.3	0.4	1.1	-0.5	1.1	0.3	0.3	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	0.8	1.4	1.4	-0.3	0.3
Commuting to job workplace: Public transport	2.7	3.3	6.0	-1.4	2.5	-0.9	-1.5	-2.3
Eye problems/disorders: Glaucoma	1.8	2.1	8.5	-0.7	-0.8	-2.9	0.8	-0.5
Medication: Blood pressure	0.1	0.1	0.3	0.5	-0.5	-0.0	-0.0	0.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.4	-1.5	1.4	0.7	2.1	1.7
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	0.5	-0.2	0.7	0.1	0.1
High cholesterol (Self-reported)	0.7	1.2	2.6	-1.2	1.3	-1.6	0.6	-0.3
Medication: Bendroflumethiazide	1.5	2.3	6.5	2.5	-1.3	-1.4	-1.1	-0.6
Medication: Paracetamol	2.9	4.4	6.7	-2.4	2.6	2.4	0.7	1.9
Medication: Lisinopril	1.7	2.2	5.8	2.3	-2.4	0.1	0.0	0.4
Medication: Atorvastatin	1.3	1.7	4.9	-2.2	-0.1	-1.6	0.9	-0.5
Illnesses of father: High blood pressure	2.2	2.7	9.2	3.0	-1.7	-0.8	-0.6	-0.5
Alcohol drinker status: Never	2.9	3.5	7.1	-1.4	2.7	1.6	-2.0	-1.2
Ever smoked	0.8	1.5	3.3	-1.0	0.3	0.5	1.8	1.6
Basal metabolic rate	0.8	4.6	6.8	1.8	-2.6	-1.0	2.6	2.3
Leg fat percentage (left)	0.9	3.2	10.7	-3.3	1.2	1.3	1.3	0.6
Arm fat-free mass (left)	0.9	4.4	7.3	1.4	-2.5	-0.9	2.7	2.4
Number of operations (self-reported)	2.0	3.0	8.3	-1.5	2.9	1.3	-1.2	-1.0
Average weekly beer plus cider intake	0.7	1.0	3.4	1.9	-0.5	-0.2	-0.4	1.0
Irritability	0.6	1.1	2.0	-1.1	0.2	-0.5	1.4	1.4
Risk taking	0.4	0.5	1.8	0.6	-0.0	-1.3	0.1	-0.7
Ever had prostate specific antigen (PSA) test	2.6	3.0	7.3	0.8	-0.4	-0.0	-2.7	-2.6
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.3	-0.5	0.6	-0.9	-0.9
Age started oral contraceptive pill	1.4	1.7	3.5	0.5	0.8	-1.1	-1.8	-1.9
Diastolic blood pressure, automated reading	0.2	0.6	2.4	0.7	-1.6	0.3	0.0	-0.4
Ever depressed for a whole week	1.7	2.1	8.1	-0.7	2.8	1.3	0.0	0.5
Unable to work because of sickness or disability	1.0	1.3	4.2	0.6	2.0	-1.3	0.5	0.3
Commuting to job workplace: Cycle	0.9	1.1	2.1	1.0	-1.4	-1.4	0.3	0.3
Myopia	0.6	0.8	3.5	-0.7	0.1	-1.9	0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.5	-0.4	-1.0	-0.1	-0.9
Cholesterol lowering medication	0.5	0.7	3.2	-1.8	-0.1	-0.1	0.3	0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.4	-0.8	1.0	0.9	-1.2	-0.3
Pain experienced in last month	0.4	0.7	1.0	0.8	-0.6	-0.9	-0.8	-1.0
Supplements: Calcium	0.3	0.3	0.4	-0.5	-0.5	0.6	0.5	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	1.1	0.7	-0.4	-0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	-0.2	0.8	1.5	-1.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.4	-0.8	1.5	0.9	0.9	1.5
Heart disease (siblings)	0.6	0.8	2.7	0.5	0.9	-1.6	-0.1	-0.5
Alcohol drinker status: Previous	0.7	0.8	2.1	-0.9	1.4	0.8	0.3	0.7
Pack years of smoking	1.5	2.2	4.4	-2.1	2.1	0.2	1.3	0.6
Impedance of whole body	0.6	2.9	8.1	0.6	-0.4	-0.0	-2.8	-2.4
Leg fat mass (left)	0.5	2.0	3.9	-2.0	0.2	0.8	1.9	1.4
Arm predicted mass (left)	0.9	4.8	7.6	1.7	-2.7	-1.1	2.8	2.3