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chr14:54,345,797-56,575,157

Best TWAS P=2.91e-20 · Best GWAS P=7.83e-18 conditioned to 0.000131

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATG14	0.03	0.02	blup	438	0.02	7.6e-04	8.2	8.4	5.8e-17	0.49	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FBXO34	0.05	0.10	lasso	4	0.09	2.5e-11	8.1	-8.0	1.2e-15	-0.39	0.06	0.94	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LGALS3	0.03	0.03	blup	421	0.02	1.2e-03	7.9	-6.0	1.4e-09	-0.32	0.07	0.91	FALSE
4	CommonMind	Brain Pre-frontal Cortex	WDHD1	0.06	0.09	enet	24	0.09	5.7e-11	5.3	-5.2	1.7e-07	-0.21	0.96	0.04	FALSE
5	GTEx	Adipose Subcutaneous	ATG14	0.08	0.01	enet	30	0.06	2.1e-05	8.2	-7.4	1.4e-13	-0.40	0.14	0.84	FALSE
6	GTEx	Adrenal Gland	LGALS3	0.19	0.17	lasso	2	0.12	3.0e-05	7.7	-7.8	8.0e-15	-0.38	0.36	0.54	FALSE
7	GTEx	Artery Aorta	LGALS3	0.12	0.03	enet	7	0.03	7.0e-03	8.4	-7.8	7.2e-15	-0.31	0.04	0.93	FALSE
8	GTEx	Artery Tibial	ATG14	0.05	0.06	enet	16	0.04	5.3e-04	8.0	-8.8	8.5e-19	-0.46	0.10	0.83	FALSE
9	GTEx	Cells Transformed fibroblasts	ATG14	0.10	0.01	lasso	8	0.02	7.3e-03	7.2	-8.3	1.3e-16	-0.48	0.19	0.79	FALSE
10	GTEx	Cells Transformed fibroblasts	MAPK1IP1L	0.05	0.05	lasso	1	0.02	8.7e-03	8.1	8.1	6.9e-16	0.39	0.13	0.66	FALSE
11	GTEx	Esophagus Mucosa	ATG14	0.13	0.13	lasso	9	0.17	1.2e-11	7.7	-7.2	5.7e-13	-0.35	0.09	0.91	FALSE
12	GTEx	Esophagus Mucosa	WDHD1	0.10	0.01	enet	16	0.03	3.4e-03	7.9	6.9	6.2e-12	0.30	0.10	0.56	FALSE
13	GTEx	Nerve Tibial	MAPK1IP1L	0.08	0.00	lasso	4	0.02	2.1e-02	7.7	9.2	2.9e-20	0.60	0.10	0.45	TRUE
14	GTEx	Pituitary	LGALS3	0.40	0.34	enet	20	0.43	3.5e-12	3.7	-5.8	7.1e-09	-0.25	0.49	0.51	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	ATG14	0.13	0.08	lasso	7	0.07	1.8e-04	8.2	-8.0	8.7e-16	-0.39	0.20	0.66	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ATG14	0.10	0.10	lasso	3	0.15	1.0e-12	8.2	-7.9	2.9e-15	-0.36	0.18	0.82	FALSE
17	GTEx	Skin Sun Exposed Lower leg	FBXO34	0.05	0.00	enet	5	0.00	6.3e-01	8.2	-8.3	1.3e-16	-0.43	0.09	0.26	FALSE
18	GTEx	Testis	ATG14	0.12	0.16	lasso	4	0.15	3.4e-07	8.2	-8.1	6.6e-16	-0.36	0.15	0.85	FALSE
19	GTEx	Thyroid	FBXO34	0.12	0.09	lasso	6	0.10	4.3e-08	7.6	-6.6	4.5e-11	-0.32	0.85	0.15	FALSE
20	METSIM	Adipose	MAPK1IP1L	0.03	0.00	bslmm	436	0.01	4.2e-02	5.9	9.0	1.9e-19	0.38	0.35	0.29	FALSE
21	YFS	Blood	FBXO34	0.04	0.05	lasso	10	0.05	2.2e-15	3.9	6.0	2.1e-09	0.28	0.12	0.88	FALSE
22	YFS	Blood	LGALS3	0.02	0.04	enet	9	0.04	6.9e-13	7.6	-7.7	1.3e-14	-0.34	0.14	0.86	FALSE
23	YFS	Blood	SAMD4A	0.02	0.01	bslmm	454	0.01	2.7e-04	3.8	5.1	2.8e-07	0.02	0.61	0.03	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	KIAA0831	0.10	0.05	blup	66	0.04	1.9e-02	8.0	-7.9	3.7e-15	-0.45	0.04	0.59	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	KIAA0831	0.25	0.01	blup	62	0.12	2.3e-04	7.3	-7.9	3.8e-15	-0.43	0.03	0.29	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA0831	0.03	0.03	blup	63	0.02	1.2e-03	7.9	-7.6	2.5e-14	-0.44	0.06	0.77	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0831	0.02	0.04	lasso	1	0.04	2.2e-05	8.4	-8.4	5.7e-17	-0.44	0.02	0.90	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBXO34	0.02	0.02	blup	95	0.02	2.4e-03	8.4	8.3	1.1e-16	0.44	0.03	0.87	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA0831	0.03	0.02	enet	19	0.02	6.7e-04	8.3	-8.1	8.1e-16	-0.52	0.02	0.72	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	FBXO34	0.11	0.08	lasso	4	0.08	4.4e-09	7.9	6.0	2.4e-09	0.41	0.38	0.62	FALSE