Best TWAS P=7.9e-20 · Best GWAS P=2.52e-77 conditioned to 2.24e-48
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PIGH | 0.32 | 0.20 | lasso | 3 | 0.15 | 1.0e-05 | 3.09 | 5.2 | 2.2e-07 | -0.19 | 0.26 | 0.42 | FALSE |
| 2 | GTEx | Lung | TMEM229B | 0.16 | 0.00 | enet | 32 | 0.00 | 2.0e-01 | -12.21 | -5.9 | 3.1e-09 | 0.37 | 0.03 | 0.29 | FALSE |
| 3 | GTEx | Muscle Skeletal | ZFYVE26 | 0.06 | 0.01 | enet | 37 | 0.01 | 5.8e-02 | -7.74 | -6.3 | 3.2e-10 | 0.34 | 0.26 | 0.07 | FALSE |
| 4 | GTEx | Testis | PIGH | 0.18 | 0.09 | enet | 44 | 0.08 | 2.4e-04 | -2.52 | -6.1 | 1.3e-09 | 0.23 | 0.21 | 0.11 | FALSE |
| 5 | GTEx | Thyroid | VTI1B | 0.18 | 0.03 | enet | 27 | 0.09 | 1.1e-07 | -9.57 | -9.1 | 7.9e-20 | 0.46 | 0.62 | 0.03 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VTI1B | 0.02 | 0.00 | blup | 39 | 0.01 | 7.3e-03 | -4.67 | -7.9 | 3.5e-15 | 0.46 | 0.02 | 0.37 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAD51L1 | 0.04 | 0.00 | blup | 471 | 0.00 | 9.9e-02 | -1.38 | -6.7 | 2.3e-11 | 0.61 | 0.08 | 0.18 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RDH12 | 0.12 | 0.00 | enet | 14 | 0.04 | 1.4e-02 | -0.29 | -7.2 | 8.9e-13 | 0.34 | 0.01 | 0.53 | TRUE |