TWAS hub - RDH12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0542	0.0294	0.02100	0.018	0.004	0.036	0.013	0.022	0.00075	0.07100	3.6e-06	0.0038	0.00025
2	TCGA	Bladder Urothelial Carcinoma	0.0390	0.0230	0.00790	0.028	0.019	0.018	NA	0.022	0.00200	0.00930	1.0e-02	NA	0.00530
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0640	0.0370	0.00310	0.046	0.038	0.014	NA	0.038	0.00120	0.00290	4.8e-02	NA	0.00320
4	TCGA	Lung Adenocarcinoma	0.0569	0.0274	0.00034	-0.002	0.023	0.029	NA	0.001	0.67000	0.00083	2.1e-04	NA	0.22000
5	TCGA	Testicular Germ Cell Tumors	0.1250	0.0630	0.00180	0.000	0.026	0.041	NA	0.006	0.32000	0.04200	1.4e-02	NA	0.19000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Depression (Nagel 2018)	4.6	6.9	9.0	-1.3	-3.0	-2.8	-2.7	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	4.0	5.3	8.5	-0.9	-2.7	-2.9	-2.2	-2.3
Illnesses of siblings: Diabetes	3.2	3.9	5.7	0.2	-2.1	-2.4	-2.0	-2.4
Length of working week for main job	3.1	3.5	8.9	-0.6	-2.3	-1.0	-1.3	-3.0
Severe depression (siblings)	2.9	3.2	5.7	1.6	-2.4	-1.5	-0.4	-2.4
Diverticular disease/diverticulitis (self-reported)	2.8	3.3	4.7	0.6	-2.1	-2.1	-1.7	-2.2
Tinnitus: Yes, now most or all of the time	2.7	3.2	9.5	3.1	1.6	1.7	-0.2	0.9
Medication for hormone replacement therapy	2.3	2.6	7.7	2.8	1.8	1.1	-0.4	0.6
Relative age voice broke	2.3	3.5	6.5	2.6	1.6	2.0	1.7	1.4
High blood pressure (mother)	2.3	3.2	7.9	1.6	2.1	2.8	0.9	0.8
Eye problems/disorders: Glaucoma	2.3	2.7	4.8	0.5	-1.7	-1.4	-1.9	-2.2
Frequency of depressed mood in last 2 weeks	2.2	3.1	6.3	-0.8	-2.2	-2.5	-1.5	-1.3
Heart disease (siblings)	2.2	2.7	3.7	1.9	1.5	1.3	1.5	1.9
Medication: Atenolol	2.0	2.5	4.3	1.8	-1.2	-0.9	-2.1	-1.7
Lung cancer (father)	2.0	2.3	3.5	-1.9	-1.6	-1.5	-1.5	-1.1
Loneliness, isolation	2.0	2.8	4.5	-0.2	-2.1	-1.9	-1.4	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.2	1.4	-1.5	-1.3	-1.8	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	6.9	0.2	-0.8	-1.7	-2.6	-0.7
Lupus	1.8	2.7	6.2	-0.8	1.3	1.5	2.5	1.7
Time employed in main current job	1.8	2.1	3.5	-1.9	-1.6	-1.2	-0.8	-1.5
Falls in the last year	1.8	2.5	5.0	-0.3	-2.0	-2.2	-0.9	-1.6
Depression (self-reported)	1.8	2.2	3.2	-1.1	-1.5	-1.8	-1.2	-1.6
Body Mass Index (BMI) (2010)	1.7	2.3	4.7	0.8	1.9	1.3	1.0	2.2
Nervous feelings	1.7	3.2	7.3	-0.5	-2.2	-2.7	-1.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.2	0.1	-1.8	-2.1	-1.9	-1.3
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.1	-1.0	-1.7	-1.8	-0.4	-1.7
Ever depressed for a whole week	1.7	2.1	3.2	0.7	1.5	1.8	1.6	1.4
Myopia	1.7	2.5	4.3	2.1	1.6	2.0	0.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.1	-0.2	-2.0	-1.9	-1.3	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.9	-2.0	-0.6	-1.3	-1.5	-0.4
Relative age of first facial hair	1.5	3.2	9.0	1.4	0.6	1.4	3.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.4	0.9	1.6	1.8	0.5	1.2
Hair/balding pattern: Pattern 3	1.5	2.2	5.9	0.5	1.1	1.7	2.4	0.9
Angina (self-reported)	1.5	2.0	4.6	0.1	-2.0	-2.2	-0.9	-0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.9	2.6	-1.2	-1.5	-1.6	-1.3	-1.1
Fasting Glucose	1.4	1.6	2.9	-0.0	1.5	1.0	1.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.0	1.1	1.9	2.4	1.2	1.4
Angina	1.3	1.8	4.3	0.1	-1.9	-2.1	-0.8	-0.4
Maternal smoking around birth	1.3	1.9	2.6	0.6	1.5	1.6	1.6	1.4
Stomach or abdominal pain in last month	1.3	1.6	3.5	0.5	-1.8	-1.9	0.4	-0.8
Pain all over the body in last month	1.3	1.4	2.0	1.0	-1.4	-1.1	-1.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	3.3	0.8	-1.8	-1.6	1.1	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.3	-1.1	-1.4	-1.4	-0.1	-1.5
Illnesses of father: High blood pressure	1.3	1.6	3.0	1.4	1.3	1.7	0.9	0.7
Alzheimer’s Disease (in mother)	1.2	1.4	4.8	-0.7	-0.1	-1.1	-2.2	-0.8
Blood Platelet Count	1.2	14.0	51.1	2.5	-2.7	0.6	-2.3	-7.2
Blood Red Count	1.2	11.8	32.3	-2.2	2.9	1.2	3.5	5.7
Allergy or Eczema	1.2	3.2	4.8	2.2	1.8	1.8	0.4	2.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.3	-1.8	-1.4	-1.6	-0.4	-1.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.6	0.6	1.6	1.4	0.7	1.4
Noisy workplace	1.2	1.4	2.7	-1.5	0.5	0.2	1.7	1.4
Mouth/teeth dental problems: Dentures	1.2	2.1	2.7	1.3	-1.4	-1.3	-1.6	-1.5
Emphysema/chronic bronchitis	1.2	1.3	2.6	-1.2	-0.6	-1.2	-1.6	-0.9
Had major operations	1.2	1.4	2.4	0.7	-1.6	-1.2	-1.0	-1.2
Arm fat mass (left)	1.2	4.9	6.8	1.5	2.6	2.4	1.8	2.6
Arm predicted mass (left)	1.2	5.9	10.6	1.9	2.5	3.3	2.5	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.3	5.4	2.2	1.8	2.3	-0.3	1.8
Supplements: Zinc	1.1	1.2	2.6	0.5	-1.1	-1.1	-0.8	-1.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.0	2.0	0.6	0.6	-0.3	1.2
Body mass index (BMI)	1.1	4.6	7.4	1.6	2.4	1.9	2.0	2.7
Past tobacco smoking	1.1	2.0	4.5	-0.8	2.1	1.9	0.8	0.8
Illnesses of siblings	1.1	1.6	2.1	-1.4	1.4	1.4	-0.3	1.3
Weight	1.1	5.3	7.6	1.4	2.7	2.8	2.0	2.4
Father’s age at death	1.1	1.5	2.0	1.3	1.2	0.8	-1.4	1.3
Happiness	1.1	1.3	2.1	-0.8	-0.6	-1.5	-1.5	-1.1
Prospective memory result	1.1	1.3	3.0	-0.8	-1.3	-0.6	1.7	-1.0
Arm fat mass (right)	1.1	4.7	6.5	1.7	2.5	2.2	1.7	2.5
Chest pain or discomfort	1.1	1.6	2.9	-0.1	-1.1	-1.7	-1.7	-0.9
Commuting to job workplace: Walk	1.1	1.1	2.4	-0.7	1.4	0.8	-0.5	1.6
Alcohol drinker status: Never	1.1	1.4	2.3	-0.1	-1.4	-1.3	-1.0	-1.5
Arm fat-free mass (left)	1.1	5.7	9.8	1.9	2.4	3.1	2.5	1.8
Basal cell carcinoma (self-reported)	1.1	1.3	2.0	0.2	-1.4	-1.3	-1.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.4	-0.4	-1.1	-1.1	-1.4	-1.6
Depressed Affect (Nagel 2018)	1.0	2.1	4.1	-0.1	-1.7	-2.0	-1.6	-1.0
Crohns Disease (2017)	1.0	2.2	2.9	0.3	1.6	1.6	1.6	1.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.6	2.1	1.4	1.3	0.1	1.6
Supplements: Glucosamine	1.0	1.2	3.7	-1.9	-0.6	-0.7	-0.5	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.5	-1.0	-1.4	-1.6	-1.4	-0.9
Heart attack	1.0	1.3	5.1	-0.2	-0.6	-0.9	-2.3	-0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.9	1.7	-1.2	-0.9	-0.3	-1.2
Arm fat percentage (right)	1.0	4.0	8.5	1.0	2.4	1.6	1.5	2.9
Tense / ‘highly strung’	1.0	1.7	4.2	0.5	-1.2	-1.4	-2.1	-0.8
Hair/balding pattern: Pattern 4	1.0	2.4	8.3	-2.9	-0.4	-1.8	-0.6	0.5
Blood clot in the leg (DVT)	1.0	1.3	2.0	-0.6	-1.1	-1.1	-1.2	-1.4
Glaucoma (self-reported)	1.0	1.2	2.7	0.5	-0.9	-0.6	-1.6	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.0	-0.7	-0.9	-1.4	-1.1	-1.3
Number of full brothers	1.0	1.2	2.0	-0.8	-1.1	-1.4	-1.2	-0.9
Medication: Allopurinol	1.0	1.3	2.2	-0.0	1.3	1.5	1.4	0.9
Mood swings	1.0	1.9	3.2	-1.0	-1.8	-1.8	-0.2	-1.3
Commuting to job workplace: Public transport	1.0	1.2	3.8	2.0	0.7	0.9	0.1	0.9
Bipolar Disorder (2018)	0.9	1.4	2.8	-1.1	-1.3	-1.1	-0.5	-1.7
Neuroticism (Nagel 2018)	0.9	2.2	4.3	0.1	-1.8	-2.1	-1.6	-0.9
Worry (Nagel 2018)	0.9	2.0	4.2	0.8	-1.2	-1.5	-2.0	-1.1
Breast Cancer	0.9	2.3	5.3	2.3	-0.7	0.5	-0.3	-2.3
Crohns Disease (2012)	0.9	1.5	2.6	0.4	1.6	1.6	1.2	0.9
Multivitamins +/- minerals	0.9	1.2	2.2	-1.1	-1.1	-0.8	-0.9	-1.5
Had other major operations	0.9	1.1	1.9	-0.7	1.3	1.4	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.5	1.9	-0.9	-0.4	0.8	-0.3
Pulse wave Arterial Stiffness index	0.9	1.1	2.1	0.5	1.1	1.2	0.5	1.4
Arm fat-free mass (right)	0.9	4.7	8.3	2.2	2.0	2.9	2.2	1.3
Pulse wave peak to peak time	0.9	1.0	2.4	-0.5	-1.0	-1.0	-0.7	-1.6
Arm predicted mass (right)	0.9	4.6	8.0	2.2	2.0	2.8	2.2	1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.4	0.6	1.5	1.3	0.5	0.8
Ever had bowel cancer screening	0.9	1.1	2.6	1.2	0.5	0.7	0.7	1.6
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.1	-1.4	-1.3	-1.5	0.1	-0.5
HbA1C	0.8	0.8	1.6	1.2	0.1	1.0	1.3	-0.2
Medication: Metformin	0.8	1.1	2.3	-1.1	-1.0	-1.5	-0.7	-0.9
Hand grip strength (right)	0.8	2.1	6.2	-0.5	2.0	2.5	0.2	0.6
Average weekly fortified wine intake	0.8	0.9	2.4	0.3	0.5	1.1	1.5	0.7
Fed-up feelings	0.8	1.4	2.7	-1.1	-1.4	-1.6	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	-1.2	-0.5	-0.5	-1.6	-0.5
Waist circumference	0.8	2.9	5.1	0.9	2.2	1.5	1.2	2.3
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	0.1	1.0	0.7	0.6	1.8
Allergy	0.8	1.8	6.1	-2.5	-1.1	-0.9	0.7	-0.6
Diabetes (self-reported)	0.8	1.3	1.8	-1.2	-1.1	-1.3	-0.7	-1.3
Hip circumference	0.8	3.5	6.4	1.1	2.0	1.7	1.7	2.5
Medication: Lansoprazole	0.8	0.9	1.8	-0.2	-0.7	-1.2	-1.3	-0.7
Family relationship satisfaction	0.8	1.0	2.7	-1.6	-0.4	-1.1	-0.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.4	1.5	-0.2	-0.4	-1.4	-0.2
Arm fat percentage (left)	0.8	3.2	6.7	1.1	2.1	1.4	1.3	2.6
Whole body water mass	0.8	4.3	8.3	1.7	2.0	2.9	2.1	1.4
Medication: Paracetamol	0.8	1.2	4.5	0.8	0.5	-0.4	-2.1	-0.6
Basal metabolic rate	0.8	4.5	7.9	1.7	2.2	2.8	2.1	1.7
Supplements: Calcium	0.8	0.9	1.7	0.7	1.0	0.9	1.3	0.8
Prostate Cancer	0.7	1.0	1.9	0.9	-0.6	-0.7	-1.4	-1.3
HDL Cholesterol	0.7	1.2	1.5	1.2	1.2	1.1	1.0	0.8
Leg fat-free mass (left)	0.7	3.7	5.3	1.6	1.8	2.3	2.0	1.8
Leg predicted mass (left)	0.7	4.0	5.6	1.7	1.9	2.4	2.1	1.9
Trunk fat-free mass	0.7	3.9	8.8	1.4	2.0	3.0	1.9	1.1
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-1.6	-0.4	-0.8	1.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.2	-1.1	-1.1	-1.0	0.9	-0.6
Trunk predicted mass	0.7	4.1	8.9	1.5	2.1	3.0	2.0	1.1
Medication: Amlodipine	0.7	0.9	2.4	-0.1	0.9	1.1	1.6	0.4
Medication: Ibuprofen	0.7	0.8	1.7	-0.8	-1.1	-1.3	0.5	-0.5
Medication: Omeprazole	0.7	0.9	2.1	-1.2	-0.0	-0.8	-1.4	-0.5
Whole body fat mass	0.7	2.8	4.2	1.6	1.8	1.5	1.4	2.0
Leg fat mass (right)	0.7	2.6	3.3	1.6	1.6	1.4	1.7	1.8
Age at last live birth	0.7	1.0	1.8	0.2	1.2	1.3	0.7	1.0
Leg pain on walking	0.7	0.9	2.5	0.0	1.2	1.6	0.7	-0.1
Whole body fat-free mass	0.7	3.9	7.5	1.6	1.9	2.7	2.0	1.3
Diabetes diagnosed by doctor	0.7	1.2	2.6	-0.8	-1.2	-1.6	-0.6	-1.0
Friendships satisfaction	0.7	0.9	2.8	-0.4	0.2	-1.1	-1.7	0.4
Eye problems/disorders: Cataract	0.7	0.8	1.9	1.4	0.1	0.2	0.8	1.1
Medication for cholesterol	0.7	1.1	1.7	-1.3	-1.2	-1.2	-0.5	-0.8
Mineral and other dietary supplements	0.7	0.9	2.1	1.5	0.7	1.3	0.2	0.4
Average weekly beer plus cider intake	0.7	1.0	1.5	1.2	-1.1	-0.5	-0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.1	-1.0	-0.3	-0.9	-1.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.9	-0.1	-0.4	-0.6	-2.0	-0.3
Leg fat mass (left)	0.7	2.7	3.6	1.5	1.6	1.5	1.7	1.9
Alzheimer’s Disease (in father)	0.6	0.7	1.3	-0.8	-0.7	-0.3	1.2	-0.9
Primary Biliary Cirrhosis	0.6	0.8	1.9	0.9	-0.8	-0.2	0.8	-1.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.0	-0.8	0.7	1.0	1.0	0.2
Trunk fat percentage	0.6	2.5	4.9	1.5	1.8	1.2	0.8	2.2
Serious illness, injury or assault to yourself	0.6	0.7	2.1	0.4	0.6	1.4	1.0	0.3
Trunk fat mass	0.6	2.8	4.1	1.5	1.9	1.6	1.1	2.0
Alcohol usually taken with meals	0.6	1.0	2.0	-0.3	1.0	0.8	1.1	1.4
Had menopause	0.6	0.8	1.1	-0.2	0.8	1.0	1.0	1.0
Fluid intelligence score	0.6	1.3	3.3	1.8	0.3	0.2	-1.8	0.1
Illnesses of mother	0.6	0.7	1.5	-0.7	0.5	0.4	1.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.6	1.1	-0.0	0.9	1.6	0.6
Birth weight	0.6	1.4	2.4	0.2	1.3	1.5	0.7	1.5
Body fat percentage	0.6	2.5	5.2	1.4	1.8	1.0	1.0	2.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	1.1	-1.1	-0.7	0.4	-0.6
Pulse rate, automated reading	0.6	1.9	3.5	0.3	1.7	1.9	0.8	1.5
Overall health rating	0.6	1.3	2.2	-0.1	-1.5	-1.0	1.2	-1.3
Knee pain experienced in last month	0.6	0.9	3.2	-1.8	-0.7	-0.9	-0.6	0.0
Smoking status: Previous	0.6	0.8	1.5	1.2	-1.0	-1.1	-0.6	-0.3
Leg fat-free mass (right)	0.6	3.3	5.5	1.5	1.8	2.3	1.8	1.5
Medication: Gliclazide	0.6	0.7	1.3	0.3	-0.7	-0.9	-1.1	-0.9
Leg predicted mass (right)	0.6	3.1	5.3	1.4	1.8	2.3	1.8	1.5
Irritability	0.6	0.9	2.7	0.5	-1.0	-1.6	-0.8	-0.3
Irritable Bowel Disease (IBD)	0.5	1.1	3.0	0.2	1.1	0.9	0.6	1.7
Coronary Artery Disease (CAD)	0.5	0.6	1.7	0.4	-0.6	0.7	1.3	-0.6
BMI	0.5	3.1	5.6	0.9	1.7	1.2	2.1	2.4
Neuroticism	0.5	1.1	2.7	-0.7	-1.3	-1.6	-0.9	-0.3
Chronotype (morning person)	0.5	1.2	3.6	1.0	1.3	0.2	0.2	1.9
Ever had hysterectomy (womb removed)	0.5	0.5	2.1	-0.6	0.0	0.4	1.4	0.4
Medication: Co-codamol	0.5	0.6	1.6	-0.5	-0.6	-1.3	-0.9	0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-1.0	1.1	0.5	-0.1	0.9
Neuroticism score	0.5	0.9	2.0	0.2	-1.3	-1.4	-0.9	-0.4
Exposure to tobacco smoke at home	0.5	0.6	1.9	0.4	0.5	0.3	1.4	0.7
Birth weight of first child	0.5	1.0	2.0	1.4	0.7	0.5	-1.4	0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	1.5	-0.2	-0.8	-0.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	1.0	0.3	0.0	1.1	0.9
High blood pressure (siblings)	0.5	0.8	1.7	1.1	-0.7	-0.5	1.3	-0.5
Leg fat percentage (right)	0.5	1.7	3.2	1.2	1.3	0.8	1.3	1.8
Exposure to tobacco smoke outside home	0.5	0.7	1.9	-0.2	-1.4	-0.9	0.6	-0.4
Migraine (self-reported)	0.5	0.7	2.5	0.4	0.7	1.6	0.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.1	-0.3	1.1	0.8	0.7	1.4
Back pain experienced in last month	0.5	0.7	2.8	-1.7	0.1	-0.5	0.3	0.5
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	-0.2	-0.9	-1.3	-0.4	-0.7
Hearing aid user	0.5	0.5	1.3	1.1	0.5	0.4	0.4	0.9
Medication: Bendroflumethiazide	0.5	0.7	1.8	-0.2	-0.7	-0.9	-0.7	-1.3
Medication: Atorvastatin	0.5	0.6	2.1	-0.1	-0.2	-0.5	-1.4	-0.7
Major Depression (MDD)	0.4	0.4	0.8	0.8	0.2	0.7	0.9	-0.3
Mean Putamen Volume	0.4	0.5	0.7	0.8	-0.7	-0.4	-0.7	-0.7
Triglycerides	0.4	0.6	1.7	-1.3	-1.0	-0.6	0.1	-0.3
Ulcerative Colitis	0.4	0.6	2.1	1.5	-0.4	-0.6	-0.6	0.0
Number of treatments/medications taken	0.4	0.7	1.4	-1.1	-0.1	-0.3	-0.9	-1.2
Average weekly spirits intake	0.4	0.5	0.7	-0.8	0.7	0.8	0.7	0.6
Vitamin and mineral supplements	0.4	0.6	1.1	0.4	0.8	0.6	1.0	0.9
Impedance of leg (left)	0.4	1.8	2.7	-0.6	-1.5	-1.3	-1.4	-1.6
Qualifications: None of the above	0.4	0.8	2.3	-0.1	0.8	0.2	1.5	0.9
Medication: Ramipril	0.4	0.5	0.8	-0.6	0.9	0.9	-0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.9	-0.6	-0.4	-0.6	-1.4	-0.5
Worry too long after embarrassment	0.4	0.6	2.0	1.4	-0.2	0.4	0.8	0.4
Mean time to correctly identify matches	0.4	0.8	2.7	-1.6	-0.9	-0.4	-0.1	-0.2
Supplements: Vitamin C	0.4	0.5	1.0	-0.6	1.0	0.7	0.2	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.0	-0.3	-0.9	-1.0	-0.6	-1.0
Breast cancer (self-reported)	0.4	0.4	1.3	-0.5	-0.0	-0.6	0.3	1.2
Ever smoked	0.4	0.7	2.2	0.4	-1.5	-0.9	-0.1	-0.3
Leg fat percentage (left)	0.4	1.6	3.0	1.1	1.3	0.8	1.2	1.7
Unable to work because of sickness or disability	0.4	0.5	0.8	-0.2	-0.9	-0.9	0.7	-0.5
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.8	-0.9	-0.9	-0.6	-0.3
Pack years of smoking	0.4	0.6	1.3	-0.1	1.2	0.6	0.0	1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.9	-0.4	-0.5	-0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	1.2	0.5	0.5	-1.1	0.5
Bipolar Disorder (2011)	0.3	0.2	0.9	-0.9	0.2	0.0	-0.1	-0.5
LDL Cholesterol	0.3	0.4	1.3	-1.1	0.1	-0.1	0.2	0.8
Neuroticism (2016)	0.3	0.4	1.6	1.3	0.4	0.2	0.1	0.4
Rheumatoid Arthritis	0.3	0.5	1.4	-0.3	-0.1	-0.8	1.2	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.9	-0.3	-0.6	-0.4	-0.1
Blood Eosinophil Count	0.3	2.2	5.6	-0.8	-1.3	-2.4	-1.2	-1.2
Lung FEV1/FVC ratio	0.3	1.5	2.9	1.0	-1.2	-0.6	-1.7	-1.4
Hair Pigment	0.3	8.4	22.6	-0.6	-2.8	-1.8	-2.8	-4.8
Hand grip strength (left)	0.3	0.8	2.3	-0.2	0.7	0.8	-1.5	-0.6
Sensitivity / hurt feelings	0.3	0.4	1.0	1.0	-0.3	-0.1	0.6	0.9
Hearing difficulty/problems: Yes	0.3	0.5	1.9	1.4	-0.6	-0.4	-0.1	0.2
Pack years adult smoking proportion	0.3	0.4	1.0	-0.1	1.0	0.4	0.1	0.9
Impedance of leg (right)	0.3	1.4	2.1	-0.3	-1.4	-1.2	-1.1	-1.4
Age when periods started (menarche)	0.3	0.6	1.0	-0.5	0.8	1.0	1.0	0.4
Medication: Levothyroxine sodium	0.3	0.6	1.2	0.4	-0.7	-1.1	-0.8	-0.6
Sitting height	0.3	2.3	8.2	0.8	1.6	2.9	0.4	0.2
Number of incorrect matches in round	0.3	0.5	1.5	-0.7	-0.5	-0.4	-0.4	-1.2
Mouth/teeth dental problems	0.3	0.4	0.8	-0.9	-0.5	-0.4	-0.5	-0.8
Medication: Simvastatin	0.3	0.5	1.1	0.6	0.7	0.2	0.6	1.1
Worrier / anxious feelings	0.3	0.5	1.4	1.2	-0.8	-0.2	0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	0.6	0.6	1.6	0.3	-0.1
Impedance of arm (left)	0.3	1.4	3.2	-1.0	-0.9	-1.1	-1.8	-0.8
Loud music exposure frequency	0.3	0.3	0.7	0.3	-0.7	-0.4	-0.8	-0.3
Gout (self-reported)	0.3	0.4	1.4	-1.2	0.3	0.1	0.3	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.3	0.1	-0.0	-0.6	-1.1	0.0
Forced vital capacity (FVC), Best measure	0.3	1.3	4.1	0.2	0.9	2.0	1.2	0.0
Comparative body size at age 10	0.3	0.7	1.9	1.4	-0.1	-0.4	-1.2	-0.1
Age at first live birth	0.3	0.5	0.9	-0.3	0.8	0.9	0.6	0.6
Qualifications: College or University degree	0.3	0.9	3.6	1.9	-0.1	0.6	-0.7	-0.4
Eye problems/disorders: None of the above	0.3	0.4	1.1	-0.2	1.1	0.7	-0.3	0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.9	0.6	-0.3	-0.5	0.5
Comparative height size at age 10	0.3	1.5	3.9	-0.5	-0.9	-0.1	-2.0	-1.6
Number of full sisters	0.3	0.4	1.5	0.5	-0.3	-0.3	1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.6	-0.8	-0.7	0.2	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.1	-0.9	-0.5	0.1	-0.9
High cholesterol (Self-reported)	0.3	0.6	1.1	0.9	0.7	0.6	1.0	0.6
Cholesterol lowering medication	0.3	0.5	1.1	-0.2	0.6	0.6	1.0	0.7
Pain experienced in last month	0.3	0.5	1.7	1.3	0.6	0.7	-0.3	-0.1
Alcohol drinker status: Previous	0.3	0.3	1.1	1.0	0.1	-0.3	-0.1	0.6
Impedance of whole body	0.3	1.4	2.4	-0.9	-1.1	-1.1	-1.6	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	-0.7	-0.1	-0.4	-0.5	-0.7
Ovarian Cancer	0.2	0.2	1.2	0.0	-0.1	0.1	-1.1	0.0
Age at First Birth	0.2	0.2	0.7	-0.1	-0.0	-0.1	0.9	0.7
Blood White Count	0.2	1.3	2.6	-1.6	1.2	-0.1	0.4	1.5
Waist Hip Ratio (WHR)	0.2	1.0	3.3	-0.5	0.6	0.1	-1.8	-0.9
Lung FVC	0.2	0.9	2.2	1.5	0.6	1.3	0.2	0.2
Diabetes (father)	0.2	0.2	0.6	0.1	0.5	0.8	0.4	0.2
Current tobacco smoking	0.2	0.3	0.8	-0.2	-0.0	-0.7	-0.9	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	0.7	-1.0	-0.6	-0.1	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.8	-0.7	-0.4	-0.2	-0.1
Forced vital capacity (FVC)	0.2	1.0	3.2	0.4	0.6	1.8	0.9	-0.6
Financial difficulties in last 2 years	0.2	0.2	0.5	0.6	0.4	-0.1	-0.0	0.7
Impedance of arm (right)	0.2	1.0	1.7	-1.1	-0.9	-1.0	-1.3	-0.6
Number of live births	0.2	0.3	1.0	0.2	0.7	0.4	0.3	1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.7	0.6	0.4	1.6	0.4	-0.8
Pulse rate	0.2	0.4	0.6	0.4	0.7	0.7	0.5	0.7
Asthma	0.2	0.4	1.4	1.2	0.5	0.0	-0.4	0.5
Medication: Cholesterol lowering	0.2	0.3	1.3	1.1	-0.3	-0.3	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.7	0.4	0.6	1.6	0.8	-0.2
Pulse wave reflection index	0.2	0.3	0.6	-0.5	-0.5	-0.4	-0.7	-0.3
Medication: Paracetamol	0.2	0.4	0.7	0.8	0.8	0.4	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	0.1	0.2	-0.4	-1.3	-0.2
Number of children fathered	0.2	0.3	0.6	-0.4	-0.7	-0.8	0.2	-0.0
Medication: Blood pressure	0.2	0.3	0.8	0.2	0.4	0.5	0.9	0.3
Heart disease (mother)	0.2	0.2	0.7	0.1	0.3	0.3	0.8	0.3
Alcohol intake frequency.	0.2	0.4	1.2	-1.1	-0.4	-0.9	0.4	0.0
Medication: Aspirin	0.2	0.3	0.7	0.1	-0.6	0.3	0.6	-0.8
Hypertension (Self-reported)	0.2	0.7	1.9	-0.6	0.7	0.8	1.4	0.2
Asthma (self-reported)	0.2	0.4	1.7	1.3	0.3	-0.2	-0.5	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.6	0.0	-0.5	-0.8	0.1
Medication: Aspirin	0.2	0.3	0.7	-0.0	-0.7	0.0	0.5	-0.8
Smoking status: Current	0.2	0.2	0.6	-0.0	-0.3	-0.7	-0.7	0.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	-0.3	-0.4	-1.2	-0.2	-0.1
Miserableness	0.2	0.3	0.5	-0.2	-0.1	-0.7	-0.7	0.7
Guilty feelings	0.2	0.3	0.6	-0.4	-0.7	-0.8	-0.0	-0.2
Wears glasses or contact lenses	0.2	0.2	0.4	0.5	0.4	0.2	0.2	0.6
Financial situation satisfaction	0.2	0.3	0.6	-0.6	-0.6	-0.8	0.1	0.3
Medication: Blood pressure	0.2	0.4	1.0	-0.1	1.0	1.0	-0.1	0.3
Medication: Lisinopril	0.2	0.2	0.6	0.2	-0.4	0.0	0.4	-0.8
Number of operations (self-reported)	0.2	0.2	0.7	-0.0	-0.5	-0.4	-0.8	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.2	-0.3	-0.5	0.3	0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.4	-0.7	-0.5	-0.2	-0.5
Schizophrenia (2018)	0.1	0.1	0.6	0.2	0.1	0.2	0.2	0.8
Ulcerative Colitis (UC)	0.1	0.1	0.6	0.1	0.2	0.0	-0.1	0.8
Reaction Time	0.1	0.3	0.8	-0.7	-0.9	-0.1	0.2	-0.2
Heel T-Score	0.1	0.6	1.3	-0.5	1.0	1.1	0.6	0.3
Height	0.1	2.3	7.8	0.2	1.1	2.8	-0.4	-1.5
Smoking Status	0.1	0.3	0.7	0.3	-0.1	-0.7	-0.8	0.5
Cardiovascular Disease	0.1	0.5	1.3	-1.1	-0.4	0.0	1.0	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.2	0.2	-0.4	-0.8	-0.0
Respiratory disease	0.1	0.2	0.6	0.2	0.6	-0.2	-0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.6	0.1	0.2	-0.3	-0.4
Systolic blood pressure, automated reading	0.1	0.3	0.9	0.2	0.9	0.8	0.5	0.1
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.3	0.1	-0.3	-0.8	0.2
Taking other prescription medications	0.1	0.1	0.4	-0.4	0.6	0.2	0.1	0.0
High blood pressure	0.1	0.3	1.1	-0.3	0.4	0.6	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.7	-0.7	-0.4	-0.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.1	-0.1	0.0	-0.5	-0.6
Standing height	0.1	1.3	5.3	-0.0	0.9	2.3	-0.1	-0.7
Breastfed as a baby	0.1	0.2	0.4	-0.4	-0.2	-0.5	0.6	0.3
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.5	-0.0	0.3	-0.1	-0.4
Headache pain in last month	0.1	0.1	0.2	-0.2	0.4	0.3	0.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	-0.6	-0.5	0.4	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.6	0.8	-0.2	0.0	-0.1	0.2
Neck or shoulder pain in last month	0.1	0.1	0.4	0.3	0.1	0.2	0.6	-0.3
Suffer from ‘nerves’	0.1	0.2	0.5	-0.7	-0.2	-0.5	0.3	0.5
Illnesses of father: Heart disease	0.1	0.2	0.4	0.2	0.4	-0.2	0.4	0.7
Average weekly red wine intake	0.1	0.1	0.5	0.7	-0.3	-0.2	0.3	0.1
Qualifications: nursing, teaching	0.1	0.1	0.2	0.2	-0.3	0.5	-0.4	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.4	0.1	0.5	0.0	-0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	0.2	0.2	0.9	0.7	-0.2
Ever taken oral contraceptive pill	0.1	0.2	0.6	0.0	0.1	0.8	-0.4	-0.1
Mother’s age at death	0.1	0.2	0.7	-0.4	-0.0	0.0	-0.8	-0.0
Risk taking	0.1	0.1	0.4	0.3	0.5	0.0	0.2	0.6
Fractured/broken bones in last 5 years	0.1	0.2	0.5	-0.7	-0.2	-0.4	-0.4	0.2
Age started oral contraceptive pill	0.1	0.1	0.4	-0.2	0.2	0.6	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.4	-0.3	-0.5	-0.7	0.2
Schizophrenia (2014)	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1	0.0
Systolic Blood Pressure	0.0	0.1	0.2	-0.1	-0.1	0.3	-0.1	-0.5
Tanning	0.0	0.6	2.0	-0.8	0.4	-0.5	-0.1	1.4
Diabetes (mother)	0.0	0.0	0.1	0.3	0.3	0.3	-0.0	0.2
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.2	0.3	-0.3	0.1	-0.2
Health satisfaction	0.0	0.1	0.2	0.2	0.4	0.1	-0.0	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.2	-0.0	-0.1	-0.4	-0.0	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.0	0.4	0.4	0.2	-0.0

Hub : Genes

RDH12

Models

Trait associations