Best TWAS P=4.27e-21 · Best GWAS P=7.3e-197 conditioned to 1.55e-141
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RIOK3 | 0.02 | 0.01 | bslmm | 348 | 0.00 | 1.8e-01 | 3.18 | 7.0 | 2.2e-12 | 0.21 | 0.14 | 0.08 | FALSE |
| 2 | GTEx | Brain Cerebellum | C18orf8 | 0.23 | 0.18 | enet | 13 | 0.21 | 9.9e-07 | 4.05 | 5.1 | 3.0e-07 | 0.13 | 0.83 | 0.01 | TRUE |
| 3 | GTEx | Nerve Tibial | TMEM241 | 0.16 | 0.04 | enet | 10 | 0.07 | 1.8e-05 | 2.25 | 5.8 | 6.3e-09 | 0.21 | 0.71 | 0.01 | FALSE |
| 4 | GTEx | Testis | C18orf8 | 0.12 | 0.07 | lasso | 6 | 0.08 | 1.9e-04 | 4.07 | 8.4 | 4.4e-17 | 0.23 | 0.29 | 0.07 | TRUE |
| 5 | METSIM | Adipose | C18orf8 | 0.08 | 0.02 | enet | 23 | 0.04 | 1.0e-06 | -4.92 | 5.9 | 3.0e-09 | 0.22 | 0.80 | 0.01 | FALSE |
| 6 | YFS | Blood | RIOK3 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.5e-07 | 6.50 | -6.8 | 1.1e-11 | 0.05 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C18orf45 | 0.08 | 0.01 | blup | 115 | 0.02 | 2.1e-03 | 0.86 | 5.5 | 3.2e-08 | 0.18 | 0.28 | 0.03 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CABLES1 | 0.10 | 0.00 | enet | 14 | 0.01 | 2.0e-02 | -3.20 | 9.4 | 4.3e-21 | 0.29 | 0.01 | 0.22 | TRUE |