[Hub]/) : Traits : Blood Platelet Count :

chr3:11,350,553-14,160,255

Best TWAS P=2.71e-26 · Best GWAS P=6.74e-73 conditioned to 1.44e-24

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SYN2 0.10 0.04 lasso 5 0.05 9.3e-05 7.7 8.0 9.5e-16 -0.34 0.86 0.04 TRUE
2 GTEx Artery Aorta TSEN2 0.11 0.01 enet 22 0.02 1.7e-02 3.2 5.4 8.2e-08 -0.09 0.40 0.03 FALSE
3 GTEx Artery Aorta SYN2 0.14 0.08 enet 15 0.09 1.0e-05 3.9 5.1 3.0e-07 -0.25 0.96 0.02 FALSE
4 GTEx Brain Cerebellum NUP210 0.34 0.24 lasso 5 0.24 1.3e-07 -6.0 6.1 1.1e-09 0.01 0.03 0.97 TRUE
5 GTEx Brain Hypothalamus TIMP4 0.24 0.10 lasso 4 0.11 1.7e-03 6.5 6.3 2.8e-10 -0.24 0.29 0.16 FALSE
6 GTEx Cells EBV-transformed lymphocytes PPARG 0.23 0.09 lasso 12 0.07 2.1e-03 8.6 9.2 5.9e-20 -0.09 0.45 0.03 TRUE
7 GTEx Cells Transformed fibroblasts CAND2 0.34 0.08 lasso 14 0.13 8.1e-10 -1.0 -7.3 3.2e-13 0.40 0.18 0.81 FALSE
8 GTEx Esophagus Gastroesophageal Junction SYN2 0.23 0.09 lasso 4 0.12 3.3e-05 7.6 7.7 1.6e-14 -0.29 0.84 0.02 FALSE
9 GTEx Esophagus Mucosa SYN2 0.25 0.17 lasso 6 0.17 1.1e-11 7.8 6.4 1.3e-10 -0.34 1.00 0.00 FALSE
10 GTEx Esophagus Muscularis TSEN2 0.12 0.03 enet 36 0.05 5.6e-04 -2.2 7.4 1.0e-13 -0.28 0.09 0.22 FALSE
11 GTEx Esophagus Muscularis SYN2 0.20 0.18 lasso 6 0.18 5.1e-11 7.7 7.6 2.6e-14 -0.34 1.00 0.00 FALSE
12 GTEx Heart Left Ventricle PPARG 0.25 0.07 enet 36 0.10 5.1e-06 9.1 5.7 1.3e-08 -0.17 0.68 0.03 FALSE
13 GTEx Heart Left Ventricle SYN2 0.15 0.14 lasso 7 0.11 3.0e-06 6.5 8.9 5.9e-19 -0.41 0.90 0.05 FALSE
14 GTEx Lung SYN2 0.19 0.12 lasso 6 0.12 2.1e-09 7.7 7.5 8.7e-14 -0.38 1.00 0.00 FALSE
15 GTEx Muscle Skeletal SYN2 0.18 0.10 enet 28 0.14 5.3e-14 6.5 6.8 8.8e-12 -0.24 1.00 0.00 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic SYN2 0.12 0.08 lasso 4 0.03 1.4e-02 7.7 7.6 2.3e-14 -0.36 0.76 0.01 FALSE
17 GTEx Skin Sun Exposed Lower leg SYN2 0.12 0.12 lasso 4 0.13 5.5e-11 7.7 6.0 2.1e-09 -0.31 1.00 0.00 FALSE
18 GTEx Testis SYN2 0.26 0.16 lasso 7 0.17 4.2e-08 7.7 6.6 4.3e-11 -0.40 0.88 0.08 FALSE
19 METSIM Adipose TIMP4 0.06 0.03 blup 512 0.03 4.6e-05 7.6 -6.0 2.5e-09 0.13 0.91 0.00 FALSE
20 METSIM Adipose TSEN2 0.06 0.02 enet 30 0.06 9.3e-10 -10.8 10.6 2.7e-26 -0.57 0.48 0.51 TRUE
21 YFS Blood NUP210 0.14 0.26 lasso 6 0.26 8.5e-85 -5.8 -5.8 6.4e-09 -0.02 0.03 0.97 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma SYN2 0.05 0.04 blup 82 0.04 3.8e-08 7.6 5.5 4.7e-08 -0.25 1.00 0.00 TRUE
23 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SYN2 0.04 0.04 lasso 2 0.04 4.9e-05 7.8 8.2 2.4e-16 -0.39 0.38 0.02 TRUE
24 The Cancer Genome Atlas Lung Adenocarcinoma SYN2 0.03 0.02 enet 6 0.02 4.0e-03 6.5 5.4 5.5e-08 -0.21 0.28 0.02 FALSE
25 The Cancer Genome Atlas Prostate Adenocarcinoma SYN2 0.11 0.12 lasso 6 0.11 1.0e-11 7.6 7.1 1.4e-12 -0.35 1.00 0.00 FALSE