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chr3:11,350,553-14,160,255

Best TWAS P=2.71e-26 · Best GWAS P=6.74e-73 conditioned to 1.44e-24

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	METSIM	Adipose	TSEN2	0.06	0.02	enet	30	0.06	9.3e-10	-10.8	10.6	2.7e-26	-0.57	0.48	0.51	TRUE
6	GTEx	Cells EBV-transformed lymphocytes	PPARG	0.23	0.09	lasso	12	0.07	2.1e-03	8.6	9.2	5.9e-20	-0.09	0.45	0.03	TRUE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYN2	0.04	0.04	lasso	2	0.04	4.9e-05	7.8	8.2	2.4e-16	-0.39	0.38	0.02	TRUE
1	GTEx	Adipose Subcutaneous	SYN2	0.10	0.04	lasso	5	0.05	9.3e-05	7.7	8.0	9.5e-16	-0.34	0.86	0.04	TRUE
4	GTEx	Brain Cerebellum	NUP210	0.34	0.24	lasso	5	0.24	1.3e-07	-6.0	6.1	1.1e-09	0.01	0.03	0.97	TRUE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYN2	0.05	0.04	blup	82	0.04	3.8e-08	7.6	5.5	4.7e-08	-0.25	1.00	0.00	TRUE
13	GTEx	Heart Left Ventricle	SYN2	0.15	0.14	lasso	7	0.11	3.0e-06	6.5	8.9	5.9e-19	-0.41	0.90	0.05	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	SYN2	0.23	0.09	lasso	4	0.12	3.3e-05	7.6	7.7	1.6e-14	-0.29	0.84	0.02	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	SYN2	0.12	0.08	lasso	4	0.03	1.4e-02	7.7	7.6	2.3e-14	-0.36	0.76	0.01	FALSE
11	GTEx	Esophagus Muscularis	SYN2	0.20	0.18	lasso	6	0.18	5.1e-11	7.7	7.6	2.6e-14	-0.34	1.00	0.00	FALSE
14	GTEx	Lung	SYN2	0.19	0.12	lasso	6	0.12	2.1e-09	7.7	7.5	8.7e-14	-0.38	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	TSEN2	0.12	0.03	enet	36	0.05	5.6e-04	-2.2	7.4	1.0e-13	-0.28	0.09	0.22	FALSE
7	GTEx	Cells Transformed fibroblasts	CAND2	0.34	0.08	lasso	14	0.13	8.1e-10	-1.0	-7.3	3.2e-13	0.40	0.18	0.81	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYN2	0.11	0.12	lasso	6	0.11	1.0e-11	7.6	7.1	1.4e-12	-0.35	1.00	0.00	FALSE
15	GTEx	Muscle Skeletal	SYN2	0.18	0.10	enet	28	0.14	5.3e-14	6.5	6.8	8.8e-12	-0.24	1.00	0.00	FALSE
18	GTEx	Testis	SYN2	0.26	0.16	lasso	7	0.17	4.2e-08	7.7	6.6	4.3e-11	-0.40	0.88	0.08	FALSE
9	GTEx	Esophagus Mucosa	SYN2	0.25	0.17	lasso	6	0.17	1.1e-11	7.8	6.4	1.3e-10	-0.34	1.00	0.00	FALSE
5	GTEx	Brain Hypothalamus	TIMP4	0.24	0.10	lasso	4	0.11	1.7e-03	6.5	6.3	2.8e-10	-0.24	0.29	0.16	FALSE
17	GTEx	Skin Sun Exposed Lower leg	SYN2	0.12	0.12	lasso	4	0.13	5.5e-11	7.7	6.0	2.1e-09	-0.31	1.00	0.00	FALSE
19	METSIM	Adipose	TIMP4	0.06	0.03	blup	512	0.03	4.6e-05	7.6	-6.0	2.5e-09	0.13	0.91	0.00	FALSE
21	YFS	Blood	NUP210	0.14	0.26	lasso	6	0.26	8.5e-85	-5.8	-5.8	6.4e-09	-0.02	0.03	0.97	FALSE
12	GTEx	Heart Left Ventricle	PPARG	0.25	0.07	enet	36	0.10	5.1e-06	9.1	5.7	1.3e-08	-0.17	0.68	0.03	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	SYN2	0.03	0.02	enet	6	0.02	4.0e-03	6.5	5.4	5.5e-08	-0.21	0.28	0.02	FALSE
2	GTEx	Artery Aorta	TSEN2	0.11	0.01	enet	22	0.02	1.7e-02	3.2	5.4	8.2e-08	-0.09	0.40	0.03	FALSE
3	GTEx	Artery Aorta	SYN2	0.14	0.08	enet	15	0.09	1.0e-05	3.9	5.1	3.0e-07	-0.25	0.96	0.02	FALSE