Best TWAS P=2.71e-26 · Best GWAS P=6.74e-73 conditioned to 1.44e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SYN2 | 0.10 | 0.04 | lasso | 5 | 0.05 | 9.3e-05 | 7.7 | 8.0 | 9.5e-16 | -0.34 | 0.86 | 0.04 | TRUE |
| 2 | GTEx | Artery Aorta | TSEN2 | 0.11 | 0.01 | enet | 22 | 0.02 | 1.7e-02 | 3.2 | 5.4 | 8.2e-08 | -0.09 | 0.40 | 0.03 | FALSE |
| 3 | GTEx | Artery Aorta | SYN2 | 0.14 | 0.08 | enet | 15 | 0.09 | 1.0e-05 | 3.9 | 5.1 | 3.0e-07 | -0.25 | 0.96 | 0.02 | FALSE |
| 4 | GTEx | Brain Cerebellum | NUP210 | 0.34 | 0.24 | lasso | 5 | 0.24 | 1.3e-07 | -6.0 | 6.1 | 1.1e-09 | 0.01 | 0.03 | 0.97 | TRUE |
| 5 | GTEx | Brain Hypothalamus | TIMP4 | 0.24 | 0.10 | lasso | 4 | 0.11 | 1.7e-03 | 6.5 | 6.3 | 2.8e-10 | -0.24 | 0.29 | 0.16 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | PPARG | 0.23 | 0.09 | lasso | 12 | 0.07 | 2.1e-03 | 8.6 | 9.2 | 5.9e-20 | -0.09 | 0.45 | 0.03 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | CAND2 | 0.34 | 0.08 | lasso | 14 | 0.13 | 8.1e-10 | -1.0 | -7.3 | 3.2e-13 | 0.40 | 0.18 | 0.81 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | SYN2 | 0.23 | 0.09 | lasso | 4 | 0.12 | 3.3e-05 | 7.6 | 7.7 | 1.6e-14 | -0.29 | 0.84 | 0.02 | FALSE |
| 9 | GTEx | Esophagus Mucosa | SYN2 | 0.25 | 0.17 | lasso | 6 | 0.17 | 1.1e-11 | 7.8 | 6.4 | 1.3e-10 | -0.34 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Muscularis | TSEN2 | 0.12 | 0.03 | enet | 36 | 0.05 | 5.6e-04 | -2.2 | 7.4 | 1.0e-13 | -0.28 | 0.09 | 0.22 | FALSE |
| 11 | GTEx | Esophagus Muscularis | SYN2 | 0.20 | 0.18 | lasso | 6 | 0.18 | 5.1e-11 | 7.7 | 7.6 | 2.6e-14 | -0.34 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Heart Left Ventricle | PPARG | 0.25 | 0.07 | enet | 36 | 0.10 | 5.1e-06 | 9.1 | 5.7 | 1.3e-08 | -0.17 | 0.68 | 0.03 | FALSE |
| 13 | GTEx | Heart Left Ventricle | SYN2 | 0.15 | 0.14 | lasso | 7 | 0.11 | 3.0e-06 | 6.5 | 8.9 | 5.9e-19 | -0.41 | 0.90 | 0.05 | FALSE |
| 14 | GTEx | Lung | SYN2 | 0.19 | 0.12 | lasso | 6 | 0.12 | 2.1e-09 | 7.7 | 7.5 | 8.7e-14 | -0.38 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Muscle Skeletal | SYN2 | 0.18 | 0.10 | enet | 28 | 0.14 | 5.3e-14 | 6.5 | 6.8 | 8.8e-12 | -0.24 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | SYN2 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.4e-02 | 7.7 | 7.6 | 2.3e-14 | -0.36 | 0.76 | 0.01 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | SYN2 | 0.12 | 0.12 | lasso | 4 | 0.13 | 5.5e-11 | 7.7 | 6.0 | 2.1e-09 | -0.31 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Testis | SYN2 | 0.26 | 0.16 | lasso | 7 | 0.17 | 4.2e-08 | 7.7 | 6.6 | 4.3e-11 | -0.40 | 0.88 | 0.08 | FALSE |
| 19 | METSIM | Adipose | TIMP4 | 0.06 | 0.03 | blup | 512 | 0.03 | 4.6e-05 | 7.6 | -6.0 | 2.5e-09 | 0.13 | 0.91 | 0.00 | FALSE |
| 20 | METSIM | Adipose | TSEN2 | 0.06 | 0.02 | enet | 30 | 0.06 | 9.3e-10 | -10.8 | 10.6 | 2.7e-26 | -0.57 | 0.48 | 0.51 | TRUE |
| 21 | YFS | Blood | NUP210 | 0.14 | 0.26 | lasso | 6 | 0.26 | 8.5e-85 | -5.8 | -5.8 | 6.4e-09 | -0.02 | 0.03 | 0.97 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SYN2 | 0.05 | 0.04 | blup | 82 | 0.04 | 3.8e-08 | 7.6 | 5.5 | 4.7e-08 | -0.25 | 1.00 | 0.00 | TRUE |
| 23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SYN2 | 0.04 | 0.04 | lasso | 2 | 0.04 | 4.9e-05 | 7.8 | 8.2 | 2.4e-16 | -0.39 | 0.38 | 0.02 | TRUE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYN2 | 0.03 | 0.02 | enet | 6 | 0.02 | 4.0e-03 | 6.5 | 5.4 | 5.5e-08 | -0.21 | 0.28 | 0.02 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SYN2 | 0.11 | 0.12 | lasso | 6 | 0.11 | 1.0e-11 | 7.6 | 7.1 | 1.4e-12 | -0.35 | 1.00 | 0.00 | FALSE |