Hub : Genes

NUP210

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3400	0.0860	1.7e-05	0.236	NA	0.130	NA	0.237	1.4e-07	NA	1.2e-04	NA	1.3e-07
2	GTEx	Muscle Skeletal	0.0846	0.0309	3.8e-03	0.031	NA	0.013	NA	0.027	4.3e-04	NA	1.6e-02	NA	1.1e-03
3	GTEx	Nerve Tibial	0.2366	0.0521	2.6e-07	0.148	NA	0.139	NA	0.146	1.3e-10	NA	4.5e-10	NA	1.7e-10
4	YFS	Blood	0.1361	0.0191	0.0e+00	0.262	0.244	0.256	0.259	0.260	1.3e-85	5.2e-79	1.9e-83	1.8e-84	8.5e-85

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.7	0.5	0.0	0.7
Bipolar Disorder or Schizophrenia	1.4	3.4	6.2	-2.3	0.2	-1.3	2.5
Depressed Affect (Nagel 2018)	0.8	1.7	3.6	0.7	1.9	1.5	-0.6
Depression (Nagel 2018)	0.2	0.2	0.9	-0.2	0.9	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.4	-0.9	1.2	0.6	1.0
Neuroticism (Nagel 2018)	0.4	0.9	2.8	-0.1	1.7	0.8	-0.0
Schizophrenia (2018)	1.9	3.9	6.8	-2.4	-0.1	-1.7	2.6
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	1.3	0.7	0.4	-1.0
Worry (Nagel 2018)	0.5	1.0	3.0	0.2	1.7	1.0	-0.3
Alzheimer’s Disease (in mother)	0.4	0.5	0.8	-0.3	-0.9	-0.9	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.5	0.3	-0.1	-0.4
Alzheimer’s Disease (including proxy)	0.8	1.1	2.1	1.5	0.2	0.3	-1.5
Crohns Disease (2017)	0.4	0.8	1.5	0.6	1.2	1.1	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.2	0.5	0.5	0.4
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.7	-0.3	-0.2	0.9
Major Depression (MDD)	0.5	0.6	1.3	1.1	0.6	0.0	-0.9
Reaction Time	0.2	0.3	0.4	0.5	-0.6	-0.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.7	-0.5	0.7	-0.1	0.8
Breast Cancer	0.2	0.6	0.8	-0.9	0.4	-0.8	0.9
Ovarian Cancer	0.1	0.1	0.3	0.2	0.3	0.6	-0.1
Prostate Cancer	1.5	2.1	2.4	-1.5	-1.6	-1.3	1.4
Age at First Birth	0.2	0.3	0.4	-0.5	0.5	-0.5	0.6
Bipolar Disorder (2011)	0.6	0.6	1.0	-1.0	-0.3	-0.6	1.0
Body Mass Index (BMI) (2010)	1.6	2.2	3.9	-1.9	-0.7	-0.9	2.0
Coronary Artery Disease (CAD)	1.8	2.2	3.0	-1.7	-1.5	-1.1	1.5
Crohns Disease (2012)	0.3	0.5	0.7	-0.9	-0.5	-0.5	0.9
Mean Putamen Volume	0.6	0.7	1.8	1.0	-0.5	0.0	-1.3
Fasting Glucose	0.5	0.6	1.2	-0.6	1.1	0.3	0.8
HbA1C	0.1	0.2	0.5	-0.3	0.0	0.7	0.0
HDL Cholesterol	2.8	4.7	8.0	2.0	2.8	1.7	-2.0
LDL Cholesterol	0.2	0.3	0.6	0.8	0.4	0.4	-0.5
Lupus	2.6	3.9	5.5	2.4	1.1	1.9	-2.3
Neuroticism (2016)	1.9	2.7	4.3	-2.1	-0.6	-1.5	2.0
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.6	0.3	0.0	0.5
Rheumatoid Arthritis	0.4	0.5	1.1	0.6	0.6	1.1	-0.4
Schizophrenia (2014)	1.4	3.1	4.2	-1.9	-0.7	-2.0	2.1
Triglycerides	1.3	2.1	3.7	-1.2	-1.9	-1.3	1.3
Type 2 Diabetes (T2D) (2012)	3.6	4.1	6.2	-2.3	-1.3	-1.8	2.5
Ulcerative Colitis	0.7	1.0	2.1	-1.3	-0.0	-0.3	1.5
Blood Eosinophil Count	0.4	2.9	5.2	-2.1	-0.0	-1.3	2.3
Blood Platelet Count	2.2	25.1	37.1	6.1	3.2	4.4	-5.8
Blood Red Count	0.0	0.1	0.3	0.2	-0.3	0.5	-0.4
Blood White Count	0.0	0.1	0.3	-0.2	0.5	0.0	0.5
Heel T-Score	0.2	1.3	2.2	1.3	0.8	0.6	-1.5
BMI	3.1	18.0	25.3	-5.0	-2.8	-3.9	4.9
Height	0.3	5.5	12.2	2.9	0.1	1.2	-3.5
Waist Hip Ratio (WHR)	0.0	0.2	0.4	-0.2	-0.6	-0.6	0.1
Systolic Blood Pressure	1.8	9.0	11.0	-3.1	-2.4	-3.3	3.1
Smoking Status	0.4	1.0	1.9	-1.4	0.4	-0.5	1.3
Allergy or Eczema	1.2	3.1	4.8	-1.9	-1.4	-1.5	2.2
Cardiovascular Disease	0.8	2.6	5.0	-1.9	-0.1	-1.4	2.2
Hypothyroidism (self reported)	1.4	3.2	5.4	-2.3	-1.1	-0.9	2.3
Respiratory disease	0.2	0.5	1.0	1.0	0.1	0.3	-0.9
Type 2 Diabetes (T2D) (2018)	2.5	4.6	8.8	-2.7	0.3	-1.5	3.0
Lung FEV1/FVC ratio	0.0	0.2	0.8	-0.3	-0.9	0.3	0.2
Lung FVC	0.2	0.9	1.2	1.0	0.3	1.1	-1.1
Neuroticism	0.8	2.0	5.2	0.7	2.3	1.5	-0.5
Chronotype (morning person)	0.0	0.1	0.2	0.2	-0.4	-0.3	-0.4
Hair Pigment	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.1
Tanning	0.0	0.1	0.3	-0.4	-0.5	-0.1	0.4
Hand grip strength (left)	0.5	1.3	2.4	-0.5	-1.5	-1.5	0.6
Number of treatments/medications taken	0.8	1.5	1.8	-1.3	-1.2	-1.1	1.3
Average weekly spirits intake	0.5	0.6	2.1	0.2	-1.5	-0.3	-0.1
Sensitivity / hurt feelings	1.1	1.8	4.5	0.5	2.1	1.5	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.6	0.3	1.2	0.3	-0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4
Relative age of first facial hair	1.8	3.7	4.2	2.0	1.8	1.7	-2.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.7	-1.3	-1.0	-1.6	1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-1.2	-0.4	-0.5	1.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.5	-0.3	-0.1	0.4
Systolic blood pressure, automated reading	2.4	7.0	7.7	-2.7	-2.5	-2.6	2.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.2	-0.8	-0.7	0.3
Angina	0.0	0.1	0.1	0.3	0.2	0.0	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.6	0.1	0.4	0.8	0.0
Vitamin and mineral supplements	0.1	0.2	0.3	0.3	0.1	0.5	-0.5
Supplements: Zinc	0.3	0.4	0.6	-0.5	0.8	0.2	0.7
Medication: Co-codamol	1.8	2.1	2.5	-1.6	-1.2	-1.6	1.4
Medication: Metformin	5.1	7.2	10.4	-3.1	-1.8	-2.4	3.2
Diabetes (father)	0.3	0.4	0.7	0.8	-0.2	0.2	-0.9
Diabetes (mother)	1.6	2.1	2.4	1.5	1.5	1.6	-1.2
Severe depression (siblings)	0.2	0.2	0.5	0.5	-0.4	-0.0	-0.7
Pack years adult smoking proportion	0.4	0.6	1.1	-0.9	1.1	0.1	0.7
Impedance of leg (right)	2.2	10.7	13.5	3.6	2.1	3.7	-3.5
Leg fat-free mass (left)	0.8	4.3	7.7	-1.9	-1.9	-2.8	1.5
Trunk fat percentage	0.6	2.4	4.0	-2.0	-1.4	-1.0	1.6
Hand grip strength (right)	0.2	0.6	1.2	-0.5	-0.8	-1.1	0.6
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.0	0.5	-0.2	-0.1
Current tobacco smoking	0.5	0.9	2.9	-0.2	1.7	0.8	0.2
Average weekly fortified wine intake	1.7	2.0	3.0	1.7	0.9	1.4	-1.6
Maternal smoking around birth	0.8	1.2	2.4	-1.6	0.4	-0.3	1.4
Fed-up feelings	0.7	1.2	2.8	0.5	1.7	1.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.2	0.7	0.4	-0.3
Relative age voice broke	2.9	4.4	5.4	2.3	1.7	2.1	-2.2
Taking other prescription medications	0.5	0.8	1.0	-0.9	-0.6	-1.0	1.0
Age when periods started (menarche)	0.6	1.4	1.7	-1.3	-1.1	-1.0	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.5	-0.3	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.3	-0.3	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.5	1.5	0.7	1.3	-1.9
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.2	-0.4	0.0	-0.4
Serious illness, injury or assault to yourself	2.1	2.6	5.4	-0.9	-2.3	-1.9	0.7
High blood pressure	0.7	2.0	4.7	-1.7	0.4	-0.7	2.2
Hayfever, allergic rhinitis or eczema	1.8	3.9	6.5	-2.2	-0.8	-1.9	2.5
Multivitamins +/- minerals	0.1	0.1	0.3	-0.0	0.6	-0.2	0.3
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.4	-0.8	-0.3	0.4
Supplements: Glucosamine	0.1	0.2	0.3	0.2	-0.5	-0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.8	0.4	-0.7	1.1
Medication: Atenolol	0.2	0.2	0.4	0.4	0.6	0.6	-0.2
Medication: Levothyroxine sodium	0.8	1.4	2.6	-1.5	-0.4	-0.7	1.6
Sitting height	0.4	3.0	6.1	2.1	0.7	1.1	-2.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.2	1.0	0.5	0.4
High blood pressure (mother)	1.0	1.4	2.7	-1.3	1.1	-0.4	1.6
Body mass index (BMI)	2.2	9.4	13.0	-3.6	-2.0	-2.9	3.5
Impedance of leg (left)	1.8	8.5	12.5	3.1	1.8	3.5	-3.0
Leg predicted mass (left)	0.8	4.1	7.3	-1.9	-1.9	-2.7	1.5
Trunk fat mass	0.8	3.5	5.1	-2.3	-1.7	-1.6	1.8
Waist circumference	2.2	8.0	11.0	-3.3	-2.1	-2.8	3.0
Number of incorrect matches in round	0.3	0.6	1.3	-0.5	-0.7	-1.2	0.3
Past tobacco smoking	0.8	1.5	2.7	1.0	1.2	1.6	-1.0
Alcohol usually taken with meals	0.1	0.2	0.5	-0.2	-0.3	-0.7	0.4
Nervous feelings	1.8	3.3	4.1	1.7	1.9	2.0	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.4	0.7	-0.0	0.3
Hearing difficulty/problems with background noise	0.8	1.2	2.3	0.4	-1.5	-1.5	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	0.6	-0.8	-0.6	-0.8	0.6
Had menopause	0.1	0.2	0.4	-0.2	-0.6	-0.5	0.0
Had other major operations	1.6	1.9	2.8	-1.7	-0.3	-1.4	1.7
Forced vital capacity (FVC)	1.3	5.1	9.1	2.6	0.9	1.9	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.2	-0.5	-0.3	0.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.7	1.1	0.9	1.0	-1.3
Qualifications: None of the above	0.4	0.8	1.3	1.0	1.1	0.5	-0.8
Financial difficulties in last 2 years	1.6	2.2	4.2	-2.0	-0.6	-0.8	1.9
Mouth/teeth dental problems	2.6	4.0	7.1	2.6	0.5	1.4	-2.7
Heart attack	0.1	0.2	0.4	-0.4	-0.6	-0.1	0.5
Allergy	0.8	1.8	2.5	1.4	0.9	1.6	-1.4
Pain all over the body in last month	1.1	1.2	2.4	0.8	0.8	1.5	-1.0
Diabetes (self-reported)	2.0	3.2	6.8	-2.1	0.9	-0.7	2.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.7	-1.2	0.3	-0.1	1.6
Medication: Ramipril	2.7	3.5	5.0	-2.1	-1.0	-1.9	2.2
Medication: Simvastatin	1.0	1.4	2.7	-1.4	-0.0	-1.0	1.6
Fluid intelligence score	0.2	0.5	0.8	-0.7	-0.4	-0.8	0.9
Illnesses of siblings	0.4	0.6	1.0	-0.7	-0.7	-1.0	0.5
Neuroticism score	2.0	4.2	7.6	1.3	2.8	2.4	-1.3
Weight	0.8	4.2	5.3	-2.1	-1.9	-2.3	1.8
Impedance of arm (right)	2.4	11.0	14.7	3.7	1.8	3.5	-3.8
Arm fat percentage (right)	1.3	4.9	7.8	-2.8	-1.5	-1.8	2.5
Trunk fat-free mass	0.3	1.8	4.4	-0.8	-1.4	-2.1	0.5
Hip circumference	1.0	4.1	6.0	-2.5	-1.5	-1.8	2.2
Time employed in main current job	2.0	2.4	4.2	1.4	1.1	2.0	-1.4
Alcohol intake versus 10 years previously	2.2	3.3	4.6	-2.1	-1.1	-1.7	2.1
Father’s age at death	2.1	2.8	4.5	-1.5	-2.1	-1.5	1.4
Worrier / anxious feelings	0.6	1.2	2.0	-1.4	-0.7	-0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.5	-2.1	-0.5	-1.7	2.0
Falls in the last year	0.5	0.7	1.0	1.0	-0.7	-0.7	-1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	0.3	0.2	-0.4
Number of live births	3.2	4.6	6.2	-2.5	-2.3	-1.7	2.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	5.9	2.1	1.0	1.5	-2.4
Pulse rate	0.1	0.2	0.2	0.3	0.4	0.4	-0.5
Happiness	0.1	0.2	0.3	0.5	0.0	-0.3	-0.5
Noisy workplace	0.9	1.2	1.9	-0.9	-1.4	-1.1	0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.1	1.2	1.1	1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	4.3	1.6	2.1	1.0	-1.3
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.4	0.8	0.6	1.7
Asthma	0.2	0.3	0.7	0.8	-0.2	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.1	1.4	0.3	0.9	-1.4
Medication: Cholesterol lowering	2.0	3.1	4.8	-2.1	-0.8	-1.6	2.2
Depression (self-reported)	0.5	0.6	0.9	0.9	0.7	0.3	-0.9
Medication: Lansoprazole	0.7	0.8	2.0	0.4	1.4	1.1	-0.2
Prospective memory result	0.2	0.2	0.4	-0.4	0.1	-0.6	0.6
Lung cancer (father)	0.9	1.1	1.9	1.3	0.5	0.6	-1.4
Illnesses of mother	0.8	0.9	1.3	1.2	0.2	1.0	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.5	1.8	0.3	1.0	-2.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.4	0.8	-1.0	-0.4	-1.2
Impedance of arm (left)	2.4	10.9	14.7	3.6	1.8	3.6	-3.8
Arm fat mass (right)	1.3	5.5	7.9	-2.8	-1.7	-2.2	2.5
Trunk predicted mass	0.3	1.7	4.3	-0.8	-1.3	-2.1	0.5
Standing height	0.5	5.0	11.4	2.8	-0.3	0.9	-3.4
Length of working week for main job	0.5	0.6	1.0	-1.0	-0.2	-0.4	1.0
Exposure to tobacco smoke at home	0.5	0.6	1.3	-1.1	0.1	0.3	1.0
Breastfed as a baby	0.1	0.1	0.2	-0.5	-0.0	0.2	0.3
Tense / ‘highly strung’	0.4	0.7	1.4	0.6	1.2	0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.1	0.9	-0.3	0.3
Hair/balding pattern: Pattern 4	0.6	1.5	2.4	1.1	1.1	1.5	-1.2
Birth weight of first child	0.3	0.6	2.2	-0.0	-1.5	-0.2	-0.1
Peak expiratory flow (PEF)	0.4	0.9	2.3	-0.5	-0.9	-1.5	0.4
Pulse wave reflection index	0.2	0.2	0.4	0.0	-0.5	-0.7	-0.3
Ever highly irritable/argumentative for 2 days	1.2	1.5	4.2	0.8	2.0	0.9	-0.5
Loud music exposure frequency	0.8	0.9	1.5	0.8	1.2	0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.2	1.5	1.4	1.2	-1.3
Mouth/teeth dental problems: Bleeding gums	4.4	5.7	8.7	-3.0	-0.8	-2.3	2.8
Blood clot in the leg (DVT)	4.0	5.2	6.9	2.6	1.9	1.8	-2.6
Medication: Paracetamol	1.7	2.8	6.8	0.9	2.6	1.8	-0.6
Headache pain in last month	0.1	0.2	0.6	0.8	0.0	-0.0	-0.5
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	6.9	2.6	1.2	1.7	-2.6
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	-0.4	0.4	-0.4
Gout (self-reported)	5.7	7.9	12.7	3.4	1.8	2.1	-3.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.5	-1.1	-1.2	-0.6	1.0
Medication: Amlodipine	0.7	0.9	1.3	-0.9	-1.1	-0.9	0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	-0.1	0.1	-0.4
Birth weight	0.2	0.4	0.8	0.8	-0.3	0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	-0.4	0.1	0.2	0.1
High blood pressure (siblings)	0.2	0.3	0.5	0.5	0.7	0.7	-0.1
Forced vital capacity (FVC), Best measure	0.7	2.5	5.6	1.9	-0.3	0.9	-2.4
Body fat percentage	0.9	3.7	6.1	-2.5	-1.5	-1.4	2.1
Leg fat percentage (right)	1.1	3.8	6.3	-2.5	-1.1	-1.4	2.4
Arm fat-free mass (right)	0.7	3.7	6.4	-1.7	-1.8	-2.5	1.4
Exposure to tobacco smoke outside home	0.8	1.0	3.0	-0.5	-1.7	-0.9	0.2
Comparative body size at age 10	1.9	5.2	7.0	-2.0	-2.6	-2.6	1.8
Number of full brothers	0.3	0.4	0.8	-0.1	-0.9	-0.8	0.0
Worry too long after embarrassment	1.8	3.1	3.6	1.9	1.6	1.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.9	1.5	0.4	1.1	-1.7
Wheeze or whistling in the chest in last year	2.4	4.2	6.9	-2.6	-0.4	-1.8	2.6
Number of children fathered	1.7	1.9	3.6	-1.8	-0.4	-0.9	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	1.0	-0.4	-0.1	-1.0
Age at first live birth	0.9	1.6	2.3	1.5	0.4	1.3	-1.4
Pulse wave peak to peak time	0.5	0.6	1.2	-0.7	0.7	0.3	1.1
Health satisfaction	2.0	2.5	4.9	-0.9	-2.2	-2.0	0.5
Shortness of breath walking on level ground	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1
Qualifications: College or University degree	0.1	0.2	0.3	0.5	0.4	0.6	-0.3
Eye problems/disorders: None of the above	1.5	1.8	2.6	1.5	1.1	1.0	-1.6
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	-0.4	-0.7	-0.9	0.4
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.9	0.1	-0.1	1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.1	-1.0	-0.2	-0.3
Neck or shoulder pain in last month	0.5	0.7	1.3	-0.5	-0.9	-1.2	0.7
Medication: Blood pressure	1.7	3.0	6.5	-2.2	-0.0	-0.9	2.5
Angina (self-reported)	0.0	0.1	0.1	0.3	0.3	0.1	-0.2
Migraine (self-reported)	0.3	0.4	0.6	-0.7	0.4	0.6	0.8
Medication: Ibuprofen	0.5	0.6	1.2	1.0	-0.0	0.6	-1.1
Medication: Allopurinol	0.4	0.5	1.0	0.9	0.5	0.2	-1.0
Medication: Omeprazole	0.1	0.1	0.3	-0.4	0.4	-0.1	0.5
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.3	-0.5	-0.5	0.8
Mean time to correctly identify matches	0.1	0.2	0.5	0.6	-0.3	0.2	-0.7
Heart disease (mother)	0.5	0.7	0.9	-0.8	-0.9	-0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	-0.7	0.6	-0.7	0.8
Whole body fat mass	1.1	4.6	7.0	-2.6	-1.7	-1.9	2.3
Leg fat mass (right)	1.3	5.2	7.7	-2.8	-1.5	-2.0	2.6
Arm predicted mass (right)	0.8	4.1	6.6	-1.9	-1.8	-2.6	1.6
Pulse rate, automated reading	1.3	4.3	8.7	1.2	3.0	2.5	-0.9
Alcohol intake frequency.	0.1	0.3	0.8	-0.4	-0.9	-0.5	0.5
Comparative height size at age 10	0.2	1.0	1.9	0.6	-1.4	-0.7	-1.1
Number of full sisters	0.3	0.3	0.6	-0.6	0.7	-0.4	0.5
Suffer from ‘nerves’	2.4	3.8	8.0	1.3	2.8	2.0	-1.2
Overall health rating	0.6	1.3	3.1	-0.3	-1.8	-1.5	0.1
Chest pain or discomfort	0.2	0.3	0.8	-0.5	0.5	-0.2	0.9
Had major operations	0.1	0.1	0.2	-0.2	-0.5	0.1	0.2
Age at last live birth	1.1	1.6	2.6	1.6	0.1	1.1	-1.6
Family relationship satisfaction	0.1	0.2	0.3	0.6	0.5	-0.2	-0.2
Leg pain on walking	1.1	1.4	2.8	-0.7	-1.7	-1.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.7	-1.7	-2.2	-1.5	1.2
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.9	1.2	2.0	1.2	-1.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	1.3	0.0	0.7	-1.4
Medication: Aspirin	1.3	1.7	2.7	-1.6	-0.5	-1.0	1.6
Supplements: Vitamin C	0.0	0.0	0.1	0.1	0.0	-0.2	-0.1
Knee pain experienced in last month	0.5	0.8	2.1	-0.7	-1.4	-0.9	0.3
Hypertension (Self-reported)	0.6	1.7	4.0	-1.5	0.4	-0.7	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.6	0.4	1.1	-0.5
Illnesses of father: Heart disease	1.9	2.6	3.6	-1.8	-0.7	-1.8	1.9
Illnesses of siblings: Diabetes	0.8	1.0	1.7	1.3	0.1	1.0	-1.1
Smoking status: Previous	1.6	2.3	4.3	-1.0	-1.8	-2.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.6	0.2	0.2	-0.6
Whole body fat-free mass	0.6	3.2	6.6	-1.4	-1.8	-2.6	1.1
Leg fat-free mass (right)	0.8	4.4	7.7	-1.9	-1.9	-2.8	1.6
Arm fat percentage (left)	1.2	4.6	7.5	-2.7	-1.4	-1.8	2.4
Average weekly red wine intake	1.0	1.5	3.0	1.6	0.5	0.7	-1.7
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.2	-0.1	-0.1	0.1	0.4
Mood swings	0.5	0.9	1.8	0.2	1.3	1.3	-0.4
Loneliness, isolation	0.9	1.2	2.0	0.9	1.4	1.1	-0.9
Long-standing illness, disability or infirmity	0.4	0.6	1.0	0.4	-1.0	-0.8	-0.7
Ever had bowel cancer screening	0.7	0.8	1.6	-1.1	0.2	-0.6	1.3
Diabetes diagnosed by doctor	1.5	2.5	5.4	-1.9	0.6	-0.8	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.3	0.1	-0.0	0.4
Friendships satisfaction	0.7	0.8	2.5	0.0	1.6	0.9	0.1
Qualifications: nursing, teaching	0.3	0.4	0.6	0.6	0.3	0.8	-0.7
Commuting to job workplace: Walk	1.1	1.1	3.0	-0.6	-1.7	-1.0	0.4
Eye problems/disorders: Cataract	1.1	1.2	3.1	-0.6	-1.8	-1.2	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	0.9	0.1	0.4	-1.0
Medication for cholesterol	0.5	0.8	1.7	1.1	0.0	0.7	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.8	6.5	-2.3	-1.1	-1.4	2.5
Back pain experienced in last month	0.5	0.8	1.7	1.3	0.2	0.4	-1.1
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	-0.0	-0.2	0.7
Breast cancer (self-reported)	0.3	0.4	0.8	-0.4	-0.9	-0.7	0.2
Asthma (self-reported)	0.2	0.5	0.9	1.0	0.2	-0.0	-1.0
Osteoporosis (self-reported)	1.0	1.2	1.6	-1.3	-0.9	-1.1	1.1
Osteoarthritis (self-reported)	1.3	1.6	4.0	-0.8	-2.0	-1.3	0.5
Medication: Aspirin	1.3	1.6	2.8	-1.5	-0.5	-1.1	1.7
Medication: Gliclazide	0.7	0.8	2.0	0.2	1.1	1.4	0.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.1	0.5	0.6	-0.3
Smoking status: Current	0.5	0.7	1.9	-0.4	1.4	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.4	0.5	0.6	0.3
Whole body water mass	0.6	3.4	6.8	-1.5	-1.8	-2.6	1.2
Leg predicted mass (right)	0.8	4.5	7.8	-1.9	-2.0	-2.8	1.6
Arm fat mass (left)	1.2	5.0	7.0	-2.6	-1.7	-2.1	2.3
Number of self-reported non-cancer illnesses	0.4	0.8	1.2	-1.0	-0.4	-0.8	1.1
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.2	-0.2	0.1	0.1
Miserableness	0.0	0.0	0.0	-0.1	0.2	-0.1	0.2
Guilty feelings	0.1	0.2	0.5	-0.2	0.7	-0.3	0.5
Wears glasses or contact lenses	0.3	0.3	0.5	-0.7	-0.4	0.4	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.3	-0.1	0.3	-0.4
Hearing aid user	2.4	2.7	5.5	1.9	-0.7	1.0	-2.4
Mother’s age at death	0.3	0.4	0.5	-0.6	-0.7	-0.6	0.7
Financial situation satisfaction	0.4	0.4	1.4	-0.2	-1.2	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	-0.1	0.2	0.7	-0.3
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.2	0.0	0.0	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.1	-0.4	0.2	0.2
Medication: Blood pressure	0.5	0.9	1.5	-0.9	-0.5	-1.2	1.0
Pain type(s) experienced in last month: Hip pain	2.6	3.3	4.9	-2.1	-1.2	-1.6	2.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.0	1.0	0.9	0.7	-0.9
High cholesterol (Self-reported)	0.4	0.8	1.4	-1.0	0.2	-0.8	1.2
Medication: Bendroflumethiazide	2.7	4.1	6.8	-1.9	-2.6	-1.9	1.6
Medication: Paracetamol	1.4	2.1	6.6	0.5	2.6	1.3	-0.1
Medication: Lisinopril	2.4	3.1	4.2	-1.7	-1.6	-2.1	1.7
Medication: Atorvastatin	0.1	0.2	0.3	-0.5	0.3	0.4	0.5
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.6	0.1	-0.3	-0.4
Alcohol drinker status: Never	0.8	1.0	2.2	0.9	-0.1	1.5	-0.9
Ever smoked	0.8	1.3	2.9	-1.0	-0.6	-1.7	1.0
Basal metabolic rate	0.6	3.4	6.4	-1.6	-1.7	-2.5	1.3
Leg fat percentage (left)	1.5	5.4	8.9	-3.0	-1.3	-1.6	2.9
Arm fat-free mass (left)	0.8	4.3	6.6	-2.0	-1.9	-2.6	1.7
Number of operations (self-reported)	0.1	0.1	0.4	0.2	-0.6	-0.3	-0.2
Average weekly beer plus cider intake	0.9	1.2	2.0	-1.3	1.1	-0.4	1.4
Irritability	2.2	3.7	9.1	0.6	3.0	2.2	-0.8
Risk taking	0.2	0.3	0.6	-0.8	-0.2	-0.3	0.6
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.1	-0.1	0.4	-0.0
Fractured/broken bones in last 5 years	1.3	1.6	2.6	1.2	1.0	1.6	-1.2
Age started oral contraceptive pill	0.3	0.3	1.1	-0.3	-1.1	-0.1	0.3
Diastolic blood pressure, automated reading	1.7	5.1	6.5	-2.1	-2.2	-2.5	2.2
Ever depressed for a whole week	1.3	1.6	2.9	1.2	1.7	1.0	-1.1
Unable to work because of sickness or disability	1.7	2.2	4.6	2.0	-0.3	0.5	-2.2
Commuting to job workplace: Cycle	2.6	3.1	7.1	-0.8	-2.7	-2.1	0.6
Myopia	1.2	1.8	3.1	0.7	1.8	1.7	-0.9
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.3	1.7	-0.4	1.0	-2.3
Cholesterol lowering medication	0.4	0.6	1.1	-1.0	0.4	-0.3	1.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.4	0.3	-0.2	0.7
Pain experienced in last month	0.0	0.0	0.1	-0.1	0.0	0.3	0.1
Supplements: Calcium	0.1	0.1	0.2	0.5	-0.3	-0.0	-0.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.8	-0.8	-1.7	-1.3	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.3	-0.5	-0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	3.4	4.4	5.9	2.4	1.8	1.7	-2.4
Heart disease (siblings)	0.6	0.7	1.6	-0.6	-1.3	-0.8	0.6
Alcohol drinker status: Previous	0.1	0.1	0.3	0.5	0.1	0.1	-0.4
Pack years of smoking	0.3	0.4	0.7	-0.7	0.9	0.1	0.6
Impedance of whole body	1.9	9.6	13.0	3.3	1.6	3.6	-3.4
Leg fat mass (left)	1.6	6.1	9.1	-3.0	-1.7	-2.1	2.8
Arm predicted mass (left)	0.8	3.9	6.2	-1.9	-1.8	-2.5	1.6