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chr3:49,030,828-51,398,958

Best TWAS P=3.43e-11 · Best GWAS P=5.62e-10 conditioned to 0.0269

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HYAL1	0.09	0.06	lasso	1	0.05	4.3e-05	-5.9	-5.9	4.3e-09	0.87	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	CYB561D2	0.20	0.08	lasso	8	0.11	4.0e-06	-4.7	5.7	1.1e-08	-0.71	0.32	0.49	FALSE
3	GTEx	Brain Cortex	HEMK1	0.16	0.01	enet	19	0.03	6.1e-02	-3.0	5.1	2.9e-07	-0.51	0.06	0.49	FALSE
4	GTEx	Brain Cortex	SEMA3B-AS1	0.67	-0.01	lasso	13	0.01	1.7e-01	-6.0	-5.2	1.6e-07	0.81	0.03	0.84	FALSE
5	GTEx	Brain Hypothalamus	MST1	0.32	0.13	lasso	3	0.12	9.4e-04	4.1	5.2	2.0e-07	-0.08	0.11	0.14	TRUE
6	GTEx	Esophagus Gastroesophageal Junction	HYAL1	0.30	0.13	lasso	9	0.10	2.1e-04	-5.9	-5.7	1.4e-08	0.88	0.02	0.94	FALSE
7	GTEx	Esophagus Mucosa	CYB561D2	0.07	0.02	lasso	4	0.02	3.1e-02	-5.2	5.9	3.1e-09	-0.91	0.04	0.89	FALSE
8	GTEx	Esophagus Muscularis	HYAL1	0.11	0.08	lasso	5	0.05	3.3e-04	-5.9	-5.9	4.2e-09	0.90	0.02	0.98	FALSE
9	GTEx	Heart Atrial Appendage	HYAL1	0.23	0.10	enet	14	0.13	1.5e-06	-5.1	-5.6	1.7e-08	0.84	0.01	0.98	FALSE
10	GTEx	Heart Left Ventricle	HYAL1	0.23	0.03	enet	26	0.12	5.8e-07	-5.1	-5.3	1.1e-07	0.64	0.06	0.89	FALSE
11	GTEx	Muscle Skeletal	HYAL1	0.08	0.08	lasso	3	0.06	7.6e-07	-6.0	-6.0	2.4e-09	0.92	0.01	0.99	FALSE
12	GTEx	Muscle Skeletal	CYB561D2	0.13	0.06	enet	14	0.07	1.4e-07	-5.8	5.5	4.1e-08	-0.86	0.03	0.96	FALSE
13	GTEx	Muscle Skeletal	SEMA3B-AS1	0.17	0.01	lasso	7	0.02	8.3e-03	-5.2	-5.7	1.1e-08	0.77	0.06	0.88	FALSE
14	GTEx	Nerve Tibial	U73166.2	0.07	0.03	lasso	3	0.03	2.8e-03	-5.9	6.1	8.5e-10	-0.96	0.01	0.98	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	CYB561D2	0.08	0.01	enet	7	0.02	2.3e-02	-4.7	5.8	4.8e-09	-0.71	0.10	0.59	FALSE
16	GTEx	Skin Sun Exposed Lower leg	HYAL1	0.08	0.04	lasso	4	0.04	3.4e-04	-6.2	6.1	1.0e-09	-0.94	0.00	0.99	FALSE
17	GTEx	Thyroid	CYB561D2	0.08	0.02	enet	9	0.03	2.3e-03	-5.7	5.3	1.5e-07	-0.83	0.06	0.88	FALSE
18	GTEx	Thyroid	U73166.2	0.05	0.02	enet	6	0.01	5.9e-02	-6.2	6.3	3.1e-10	-0.98	0.01	0.97	FALSE
19	GTEx	Uterus	RP11-804H8.6	0.55	0.00	lasso	3	-0.01	4.8e-01	-5.9	-5.6	1.7e-08	0.84	0.02	0.48	FALSE
20	METSIM	Adipose	CYB561D2	0.09	0.08	lasso	5	0.07	3.8e-10	-5.1	6.0	1.5e-09	-0.85	0.03	0.97	FALSE
21	METSIM	Adipose	HYAL1	0.07	0.04	enet	31	0.03	1.5e-05	-5.9	-5.3	1.3e-07	0.82	0.03	0.97	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	CACNA2D2	0.05	0.02	lasso	3	0.02	3.6e-03	-6.0	5.9	3.4e-09	-0.92	0.01	0.98	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	SEMA3B	0.05	0.03	lasso	6	0.02	8.3e-04	-5.1	-5.7	1.2e-08	0.88	0.02	0.98	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	RASSF1	0.03	0.00	bslmm	257	0.02	1.8e-03	-5.8	-6.6	3.4e-11	0.61	0.02	0.71	TRUE
25	ROSMAP	Brain Pre-frontal Cortex	HYAL1	0.10	0.04	blup	248	0.04	1.3e-05	-6.0	-6.0	2.2e-09	0.69	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYB561D2	0.10	0.02	lasso	3	0.01	1.9e-02	-5.8	5.3	1.1e-07	-0.83	0.00	0.30	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM115	0.06	0.04	lasso	3	0.05	9.7e-04	-5.8	-5.9	4.3e-09	0.86	0.02	0.74	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	HYAL1	0.10	0.06	lasso	3	0.05	1.2e-06	-6.0	-6.2	5.5e-10	0.91	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CYB561D2	0.16	0.07	enet	9	0.09	4.1e-05	-5.8	5.3	1.2e-07	-0.69	0.02	0.92	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C3orf45	0.07	0.05	enet	4	0.05	2.9e-03	-6.1	6.0	2.5e-09	-0.92	0.00	0.92	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYB561D2	0.08	0.07	lasso	2	0.09	1.7e-09	-5.8	6.3	3.8e-10	-0.93	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYB561D2	0.08	0.04	blup	17	0.08	9.3e-04	-6.0	6.2	6.7e-10	-0.86	0.01	0.76	FALSE