Best TWAS P=1.12e-21 · Best GWAS P=3.58e-25 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ERCC8 | 0.11 | 0.08 | lasso | 9 | 0.10 | 8.9e-12 | -8.0 | -7.3 | 3.5e-13 | 0.06 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | DIMT1 | 0.10 | 0.00 | lasso | 3 | 0.00 | 2.6e-01 | -3.5 | 6.1 | 1.0e-09 | 0.37 | 0.08 | 0.15 | FALSE |
| 3 | GTEx | Artery Aorta | KIF2A | 0.08 | 0.05 | enet | 6 | 0.05 | 8.8e-04 | -9.8 | 9.6 | 1.1e-21 | 0.75 | 0.35 | 0.57 | TRUE |
| 4 | GTEx | Artery Tibial | KIF2A | 0.04 | 0.04 | enet | 15 | 0.04 | 2.6e-04 | -8.0 | 8.7 | 3.3e-18 | 0.68 | 0.46 | 0.37 | TRUE |
| 5 | GTEx | Artery Tibial | DIMT1 | 0.03 | 0.01 | enet | 13 | 0.00 | 3.4e-01 | -4.3 | 6.1 | 1.1e-09 | 0.45 | 0.18 | 0.07 | TRUE |
| 6 | GTEx | Esophagus Muscularis | DIMT1 | 0.14 | 0.01 | enet | 21 | 0.03 | 4.0e-03 | -7.8 | 5.6 | 2.2e-08 | 0.28 | 0.37 | 0.05 | TRUE |
| 7 | GTEx | Testis | KIF2A | 0.07 | 0.00 | lasso | 7 | 0.02 | 3.5e-02 | -8.0 | 6.6 | 4.2e-11 | 0.57 | 0.36 | 0.28 | FALSE |
| 8 | GTEx | Testis | DIMT1 | 0.16 | 0.08 | enet | 23 | 0.13 | 2.1e-06 | -7.9 | 7.0 | 2.3e-12 | 0.72 | 0.64 | 0.34 | FALSE |
| 9 | GTEx | Testis | IPO11 | 0.17 | 0.02 | enet | 26 | 0.04 | 5.6e-03 | -8.0 | 7.0 | 2.3e-12 | 0.62 | 0.27 | 0.09 | FALSE |
| 10 | GTEx | Thyroid | ERCC8 | 0.13 | 0.19 | lasso | 3 | 0.17 | 3.4e-13 | -8.0 | -8.0 | 1.2e-15 | 0.04 | 0.26 | 0.74 | TRUE |
| 11 | GTEx | Thyroid | DIMT1 | 0.07 | 0.03 | enet | 30 | 0.02 | 1.8e-02 | -3.4 | 5.3 | 1.1e-07 | 0.38 | 0.60 | 0.06 | TRUE |
| 12 | NTR | Blood | ELOVL7 | 0.03 | 0.01 | bslmm | 339 | 0.01 | 2.7e-04 | -3.2 | 6.8 | 1.5e-11 | -0.03 | 0.02 | 0.95 | FALSE |
| 13 | YFS | Blood | ELOVL7 | 0.03 | 0.04 | lasso | 5 | 0.03 | 5.5e-11 | -3.8 | 5.8 | 8.8e-09 | -0.02 | 0.02 | 0.98 | FALSE |
| 14 | YFS | Blood | ERCC8 | 0.01 | 0.01 | blup | 317 | 0.01 | 8.5e-05 | 5.4 | 7.5 | 6.1e-14 | 0.01 | 0.63 | 0.05 | FALSE |
| 15 | YFS | Blood | KIF2A | 0.01 | 0.01 | lasso | 1 | 0.01 | 2.1e-03 | -8.0 | 8.0 | 1.2e-15 | 0.63 | 0.69 | 0.17 | TRUE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IPO11 | 0.08 | 0.02 | lasso | 4 | 0.01 | 9.3e-02 | -7.0 | -7.5 | 4.3e-14 | -0.19 | 0.22 | 0.19 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DIMT1L | 0.09 | 0.04 | lasso | 3 | 0.04 | 3.0e-08 | -7.3 | -8.9 | 5.9e-19 | -0.36 | 0.57 | 0.43 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IPO11 | 0.09 | 0.06 | blup | 127 | 0.07 | 1.7e-13 | -7.1 | -5.7 | 1.2e-08 | -0.12 | 0.94 | 0.06 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | ERCC8 | 0.09 | 0.09 | lasso | 1 | 0.08 | 2.1e-05 | 5.4 | 5.4 | 6.9e-08 | 0.00 | 0.36 | 0.08 | FALSE |
| 20 | The Cancer Genome Atlas | Esophageal Carcinoma | IPO11 | 0.14 | 0.01 | lasso | 12 | 0.01 | 1.1e-01 | -7.1 | -7.3 | 2.1e-13 | -0.17 | 0.13 | 0.06 | TRUE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IPO11 | 0.07 | 0.02 | enet | 11 | 0.05 | 2.3e-06 | -7.3 | -9.2 | 2.8e-20 | -0.52 | 0.08 | 0.90 | FALSE |
| 22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DIMT1L | 0.26 | 0.13 | lasso | 1 | 0.10 | 2.3e-06 | -7.3 | -7.3 | 2.3e-13 | -0.19 | 0.62 | 0.28 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DIMT1L | 0.06 | 0.09 | lasso | 2 | 0.08 | 3.0e-09 | -8.0 | -8.0 | 9.1e-16 | -0.62 | 0.01 | 0.99 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERCC8 | 0.09 | 0.04 | blup | 39 | 0.02 | 6.2e-03 | 3.1 | -5.5 | 3.3e-08 | 0.07 | 0.29 | 0.24 | FALSE |
| 25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IPO11 | 0.04 | 0.03 | enet | 23 | 0.02 | 2.6e-03 | -6.4 | -5.6 | 1.8e-08 | -0.24 | 0.14 | 0.20 | TRUE |
| 26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NDUFAF2 | 0.06 | 0.04 | lasso | 3 | 0.03 | 1.2e-04 | 6.8 | 6.5 | 6.7e-11 | -0.04 | 0.74 | 0.01 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Adenocarcinoma | IPO11 | 0.06 | 0.03 | lasso | 3 | 0.03 | 4.2e-04 | -7.1 | -7.5 | 9.0e-14 | -0.23 | 0.31 | 0.07 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Adenocarcinoma | KIF2A | 0.06 | 0.02 | lasso | 1 | 0.01 | 3.9e-02 | -7.1 | -7.1 | 1.5e-12 | -0.19 | 0.06 | 0.04 | FALSE |
| 29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DIMT1L | 0.06 | 0.01 | blup | 53 | 0.03 | 7.2e-05 | -7.3 | -8.9 | 7.5e-19 | -0.37 | 0.04 | 0.53 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IPO11 | 0.08 | 0.04 | blup | 127 | 0.05 | 4.2e-06 | -7.0 | -7.9 | 2.5e-15 | -0.22 | 0.92 | 0.07 | FALSE |
| 31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIF2A | 0.05 | 0.03 | lasso | 2 | 0.02 | 1.7e-03 | -7.2 | -7.1 | 1.1e-12 | -0.17 | 0.22 | 0.04 | FALSE |
| 32 | The Cancer Genome Atlas | Rectum Adenocarcinoma | DIMT1L | 0.33 | 0.15 | lasso | 6 | 0.13 | 6.0e-04 | -7.1 | -8.7 | 4.7e-18 | -0.30 | 0.02 | 0.37 | FALSE |
| 33 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DIMT1L | 0.08 | 0.04 | enet | 11 | 0.06 | 1.2e-04 | -8.0 | -9.1 | 9.8e-20 | -0.54 | 0.02 | 0.95 | FALSE |
| 34 | The Cancer Genome Atlas | Soft Tissue Sarcoma | IPO11 | 0.08 | 0.01 | lasso | 5 | 0.04 | 1.3e-03 | -3.7 | -5.8 | 5.7e-09 | -0.17 | 0.08 | 0.08 | FALSE |
| 35 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IPO11 | 0.14 | 0.05 | lasso | 3 | 0.03 | 1.6e-03 | -7.1 | -6.4 | 2.0e-10 | -0.15 | 0.37 | 0.04 | FALSE |