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chr5:59,353,199-62,621,119

Best TWAS P=1.12e-21 · Best GWAS P=3.58e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	KIF2A	0.08	0.05	enet	6	0.05	8.8e-04	-9.8	9.6	1.1e-21	0.75	0.35	0.57	TRUE
4	GTEx	Artery Tibial	KIF2A	0.04	0.04	enet	15	0.04	2.6e-04	-8.0	8.7	3.3e-18	0.68	0.46	0.37	TRUE
10	GTEx	Thyroid	ERCC8	0.13	0.19	lasso	3	0.17	3.4e-13	-8.0	-8.0	1.2e-15	0.04	0.26	0.74	TRUE
15	YFS	Blood	KIF2A	0.01	0.01	lasso	1	0.01	2.1e-03	-8.0	8.0	1.2e-15	0.63	0.69	0.17	TRUE
20	The Cancer Genome Atlas	Esophageal Carcinoma	IPO11	0.14	0.01	lasso	12	0.01	1.1e-01	-7.1	-7.3	2.1e-13	-0.17	0.13	0.06	TRUE
5	GTEx	Artery Tibial	DIMT1	0.03	0.01	enet	13	0.00	3.4e-01	-4.3	6.1	1.1e-09	0.45	0.18	0.07	TRUE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	IPO11	0.04	0.03	enet	23	0.02	2.6e-03	-6.4	-5.6	1.8e-08	-0.24	0.14	0.20	TRUE
6	GTEx	Esophagus Muscularis	DIMT1	0.14	0.01	enet	21	0.03	4.0e-03	-7.8	5.6	2.2e-08	0.28	0.37	0.05	TRUE
11	GTEx	Thyroid	DIMT1	0.07	0.03	enet	30	0.02	1.8e-02	-3.4	5.3	1.1e-07	0.38	0.60	0.06	TRUE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IPO11	0.07	0.02	enet	11	0.05	2.3e-06	-7.3	-9.2	2.8e-20	-0.52	0.08	0.90	FALSE
33	The Cancer Genome Atlas	Soft Tissue Sarcoma	DIMT1L	0.08	0.04	enet	11	0.06	1.2e-04	-8.0	-9.1	9.8e-20	-0.54	0.02	0.95	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	DIMT1L	0.09	0.04	lasso	3	0.04	3.0e-08	-7.3	-8.9	5.9e-19	-0.36	0.57	0.43	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DIMT1L	0.06	0.01	blup	53	0.03	7.2e-05	-7.3	-8.9	7.5e-19	-0.37	0.04	0.53	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	DIMT1L	0.33	0.15	lasso	6	0.13	6.0e-04	-7.1	-8.7	4.7e-18	-0.30	0.02	0.37	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	DIMT1L	0.06	0.09	lasso	2	0.08	3.0e-09	-8.0	-8.0	9.1e-16	-0.62	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IPO11	0.08	0.04	blup	127	0.05	4.2e-06	-7.0	-7.9	2.5e-15	-0.22	0.92	0.07	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IPO11	0.08	0.02	lasso	4	0.01	9.3e-02	-7.0	-7.5	4.3e-14	-0.19	0.22	0.19	FALSE
14	YFS	Blood	ERCC8	0.01	0.01	blup	317	0.01	8.5e-05	5.4	7.5	6.1e-14	0.01	0.63	0.05	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	IPO11	0.06	0.03	lasso	3	0.03	4.2e-04	-7.1	-7.5	9.0e-14	-0.23	0.31	0.07	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DIMT1L	0.26	0.13	lasso	1	0.10	2.3e-06	-7.3	-7.3	2.3e-13	-0.19	0.62	0.28	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ERCC8	0.11	0.08	lasso	9	0.10	8.9e-12	-8.0	-7.3	3.5e-13	0.06	0.16	0.84	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIF2A	0.05	0.03	lasso	2	0.02	1.7e-03	-7.2	-7.1	1.1e-12	-0.17	0.22	0.04	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	KIF2A	0.06	0.02	lasso	1	0.01	3.9e-02	-7.1	-7.1	1.5e-12	-0.19	0.06	0.04	FALSE
8	GTEx	Testis	DIMT1	0.16	0.08	enet	23	0.13	2.1e-06	-7.9	7.0	2.3e-12	0.72	0.64	0.34	FALSE
9	GTEx	Testis	IPO11	0.17	0.02	enet	26	0.04	5.6e-03	-8.0	7.0	2.3e-12	0.62	0.27	0.09	FALSE
12	NTR	Blood	ELOVL7	0.03	0.01	bslmm	339	0.01	2.7e-04	-3.2	6.8	1.5e-11	-0.03	0.02	0.95	FALSE
7	GTEx	Testis	KIF2A	0.07	0.00	lasso	7	0.02	3.5e-02	-8.0	6.6	4.2e-11	0.57	0.36	0.28	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFAF2	0.06	0.04	lasso	3	0.03	1.2e-04	6.8	6.5	6.7e-11	-0.04	0.74	0.01	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPO11	0.14	0.05	lasso	3	0.03	1.6e-03	-7.1	-6.4	2.0e-10	-0.15	0.37	0.04	FALSE
2	GTEx	Adipose Visceral Omentum	DIMT1	0.10	0.00	lasso	3	0.00	2.6e-01	-3.5	6.1	1.0e-09	0.37	0.08	0.15	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	IPO11	0.08	0.01	lasso	5	0.04	1.3e-03	-3.7	-5.8	5.7e-09	-0.17	0.08	0.08	FALSE
13	YFS	Blood	ELOVL7	0.03	0.04	lasso	5	0.03	5.5e-11	-3.8	5.8	8.8e-09	-0.02	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	IPO11	0.09	0.06	blup	127	0.07	1.7e-13	-7.1	-5.7	1.2e-08	-0.12	0.94	0.06	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERCC8	0.09	0.04	blup	39	0.02	6.2e-03	3.1	-5.5	3.3e-08	0.07	0.29	0.24	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	ERCC8	0.09	0.09	lasso	1	0.08	2.1e-05	5.4	5.4	6.9e-08	0.00	0.36	0.08	FALSE