TWAS hub - NDUFAF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0870	0.0360	1.4e-04	0.029	0.036	0.054	0.040	0.047	1.6e-04	3.2e-05	3.1e-07	1.0e-05	1.9e-06
2	GTEx	Adipose Subcutaneous	0.1030	0.0430	3.1e-03	0.065	NA	0.041	NA	0.057	5.0e-06	NA	2.7e-04	NA	1.8e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.0846	0.0286	1.4e-07	0.058	0.052	0.071	0.059	0.053	5.8e-08	3.1e-07	1.9e-09	4.2e-08	2.0e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1004	0.0450	3.3e-09	0.092	0.089	0.087	NA	0.094	1.4e-10	3.5e-10	4.6e-10	NA	1.1e-10
5	TCGA	Brain Lower Grade Glioma	0.0576	0.0449	2.1e-04	0.036	0.032	0.030	NA	0.033	4.9e-05	1.3e-04	2.2e-04	NA	1.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Smoking Status	7.7	18.5	30.0	2.2	-1.0	5.3	5.3	5.5
Unable to work because of sickness or disability	7.7	10.0	14.8	3.2	-0.3	3.8	3.5	3.5
Qualifications: None of the above	6.8	14.6	20.9	2.9	-3.0	4.6	4.5	3.7
Multivitamins +/- minerals	6.7	8.6	12.1	-3.5	-0.4	-3.0	-3.1	-3.5
Qualifications: College or University degree	6.3	19.8	30.7	-1.5	4.3	-5.5	-5.2	-4.5
Ever smoked	5.7	10.1	15.4	2.1	-0.7	3.8	3.9	3.9
Alcohol usually taken with meals	5.6	9.0	15.4	-2.3	0.5	-3.9	-3.7	-3.3
Exposure to tobacco smoke outside home	5.6	7.5	10.8	2.6	-0.6	3.3	3.2	3.1
Fractured/broken bones in last 5 years	4.7	6.1	11.4	-3.4	-0.6	-2.7	-2.2	-2.5
Average weekly beer plus cider intake	4.6	6.7	14.9	-0.1	-3.9	2.4	2.4	2.6
Past tobacco smoking	4.5	8.2	13.3	-1.3	1.3	-3.4	-3.6	-3.6
Qualifications: A levels/AS levels or equivalent	4.1	9.1	13.3	-1.4	2.5	-3.7	-3.6	-3.2
Ever had prostate specific antigen (PSA) test	4.1	4.7	6.9	0.2	2.4	-2.3	-2.4	-2.6
Illnesses of father: High blood pressure	4.0	4.9	7.1	-1.4	1.5	-2.7	-2.5	-2.6
Schizophrenia (2014)	3.9	8.7	19.3	4.4	0.9	3.0	2.9	2.3
Current tobacco smoking	3.9	6.4	10.2	1.1	-1.2	3.2	3.1	3.0
Other serious medical condition/disability diagnosed by doctor	3.8	5.0	7.6	-1.8	-0.3	-2.6	-2.7	-2.8
Townsend deprivation index at recruitment	3.8	5.3	9.0	1.0	-0.1	3.0	3.0	2.8
Falls in the last year	3.8	5.2	8.1	-2.4	1.2	-2.2	-2.4	-2.9
Father’s age at death	3.6	4.8	7.7	-1.6	0.1	-2.8	-2.7	-2.6
Length of working week for main job	3.6	4.0	7.8	-2.8	-0.6	-2.2	-2.1	-1.6
Ever had bowel cancer screening	3.5	4.1	8.3	-1.3	-0.2	-2.1	-2.5	-2.9
Mineral and other dietary supplements	3.5	4.7	7.2	2.1	-0.6	2.4	2.3	2.7
LDL Cholesterol	3.2	5.1	8.7	2.7	0.3	2.1	2.2	3.0
Vitamin and mineral supplements	3.1	4.2	7.0	2.6	0.6	1.9	2.0	2.5
Wears glasses or contact lenses	3.1	3.6	8.3	-1.6	0.5	-1.8	-1.8	-2.9
Alzheimer’s Disease (in father)	3.0	3.2	5.5	1.6	-0.1	2.3	2.3	1.8
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	6.4	-1.6	0.0	-2.3	-2.5	-2.2
Smoking status: Current	2.9	4.5	7.0	0.9	-1.3	2.6	2.6	2.5
Number of self-reported non-cancer illnesses	2.9	5.0	9.1	-0.4	0.9	-2.8	-3.0	-2.6
Number of operations (self-reported)	2.9	4.4	7.5	-2.7	0.2	-2.4	-2.2	-1.9
Schizophrenia (2018)	2.8	5.9	11.6	3.4	-0.1	2.5	2.5	2.3
Maternal smoking around birth	2.8	4.0	6.9	0.1	-2.2	2.0	2.1	2.6
Exposure to tobacco smoke at home	2.8	3.2	5.7	-1.1	-2.4	1.9	1.6	1.7
Comparative body size at age 10	2.7	7.4	10.1	1.1	3.1	-3.0	-2.7	-3.2
Hypertension (Self-reported)	2.7	7.4	15.6	0.5	2.1	-2.8	-3.0	-4.0
Tinnitus: Yes, now most or all of the time	2.7	3.2	5.8	1.4	-0.6	2.0	2.0	2.4
Qualifications: CSEs or equivalent	2.6	3.5	5.7	1.6	0.3	2.2	2.1	2.4
Hayfever, allergic rhinitis or eczema	2.6	5.7	7.7	-2.4	0.5	-2.6	-2.8	-2.7
Smoking status: Previous	2.6	3.9	7.1	0.7	-1.0	2.3	2.4	2.7
Loneliness, isolation	2.6	3.6	8.4	2.9	1.1	1.8	1.6	1.7
Commuting to job workplace: Public transport	2.6	3.1	4.7	-0.7	1.3	-2.1	-2.0	-2.2
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	8.1	-2.9	-1.9	-1.2	-1.1	-0.9
Qualifications: nursing, teaching	2.5	3.9	7.1	-1.1	2.7	-2.0	-2.0	-1.9
Supplements: Fish oil (including cod liver oil)	2.5	3.2	4.9	-1.9	0.8	-1.8	-1.9	-2.2
Supplements: Calcium	2.5	2.7	4.8	-1.3	0.3	-2.2	-1.9	-1.9
Serious illness, injury or assault to yourself	2.4	2.9	5.4	-0.7	0.6	-2.3	-2.2	-1.9
High blood pressure	2.4	6.8	14.4	0.4	1.9	-2.8	-2.9	-3.8
Number of full brothers	2.4	3.1	5.6	0.4	-1.8	1.8	1.8	2.4
Average weekly red wine intake	2.4	3.5	5.0	-1.7	1.2	-2.2	-2.2	-1.8
Ulcerative Colitis	2.3	3.3	7.1	0.0	2.7	-1.6	-1.9	-1.7
Impedance of leg (right)	2.2	10.9	17.1	2.5	-0.9	4.1	3.9	3.9
Had major operations	2.2	2.6	4.0	-1.2	1.0	-2.0	-2.0	-1.6
Financial situation satisfaction	2.2	2.7	5.1	0.3	-0.8	2.0	1.9	2.3
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.0	-1.5	-0.9	-2.0	-2.0	-1.3
Pain all over the body in last month	2.1	2.2	5.3	2.3	1.1	1.4	1.2	1.1
Health satisfaction	2.1	2.8	3.3	-1.7	-1.3	-1.7	-1.8	-1.8
Leg fat-free mass (right)	2.1	11.0	16.7	-2.3	1.2	-4.1	-4.0	-3.9
Commuting to job workplace: Walk	2.1	2.3	3.4	1.3	1.0	1.6	1.7	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	4.8	0.6	-0.7	2.0	2.2	1.6
Leg predicted mass (right)	2.1	11.0	16.6	-2.3	1.3	-4.1	-4.0	-3.9
Average weekly champagne plus white wine intake	2.1	2.9	5.1	-0.8	0.1	-2.2	-2.1	-2.1
Bipolar Disorder or Schizophrenia	2.0	4.8	10.3	3.2	0.4	2.3	2.2	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.1	2.3	1.7	1.5	1.4	1.0
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.4	-1.0	0.5	-1.8	-1.8	-1.7
Arm fat-free mass (right)	2.0	10.3	15.8	-2.0	1.7	-4.0	-3.9	-3.7
Worry too long after embarrassment	2.0	3.4	9.4	0.1	3.1	-1.2	-1.5	-2.0
Allergy or Eczema	1.9	4.9	7.5	-2.2	0.8	-2.4	-2.5	-2.7
Impedance of leg (left)	1.9	9.1	14.5	2.3	-1.2	3.8	3.5	3.4
Trunk fat-free mass	1.9	10.9	16.4	-1.4	2.6	-4.0	-3.9	-3.7
Mouth/teeth dental problems: Dentures	1.9	3.2	5.1	2.1	-0.3	2.2	2.0	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	4.0	-1.0	0.3	-1.9	-1.9	-2.0
Trunk predicted mass	1.9	10.6	16.0	-1.3	2.7	-4.0	-3.9	-3.6
Breastfed as a baby	1.9	2.3	3.1	1.0	1.7	1.5	1.8	1.5
Emphysema/chronic bronchitis	1.9	2.1	4.8	2.2	1.7	1.2	0.9	0.8
Whole body water mass	1.9	10.6	16.3	-1.8	2.0	-4.0	-3.9	-3.7
Schizophrenia vs Biploar Disorder	1.8	2.4	5.8	2.4	0.1	1.3	1.4	1.5
Lung FVC	1.8	9.0	12.2	3.0	0.9	3.3	3.4	3.5
Arm predicted mass (right)	1.8	9.0	13.4	-1.9	1.7	-3.7	-3.6	-3.5
Whole body fat-free mass	1.8	10.5	16.1	-1.8	2.1	-4.0	-3.9	-3.7
Verbal and Numeric Reasoning (VNR)	1.7	4.0	6.1	-1.8	1.5	-2.5	-2.4	-1.7
Taking other prescription medications	1.7	2.5	4.1	-0.5	0.8	-1.9	-2.0	-2.0
Chronic bronchitis/emphysema (father)	1.7	2.0	3.2	1.8	0.8	1.3	1.4	1.6
Leg predicted mass (left)	1.7	9.0	13.5	-2.0	1.5	-3.7	-3.6	-3.5
Intelligence (Savage-Jansen 2018)	1.6	4.8	5.6	-2.1	2.3	-2.4	-2.3	-1.8
Blood Platelet Count	1.6	18.5	42.6	1.8	-0.8	4.5	5.0	6.5
Lung FEV1/FVC ratio	1.6	7.9	10.3	-3.1	0.5	-3.2	-3.0	-3.2
Leg fat-free mass (left)	1.6	8.6	12.9	-1.9	1.6	-3.6	-3.5	-3.4
Hearing aid user	1.6	1.8	2.5	-1.4	1.1	-1.6	-1.3	-1.3
Ovarian Cancer	1.5	1.9	3.2	1.8	0.8	1.8	1.6	0.6
Body Mass Index (BMI) (2010)	1.5	2.0	2.6	1.4	1.1	1.6	1.6	1.4
Average weekly spirits intake	1.5	1.9	2.8	1.5	0.3	1.7	1.6	1.3
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.4	-1.0	2.1	-1.8	-1.7	-0.7
Basal metabolic rate	1.5	8.1	12.5	-1.7	1.8	-3.5	-3.4	-3.2
Arm fat-free mass (left)	1.5	7.8	12.2	-1.8	1.5	-3.5	-3.3	-3.2
Vascular/heart problems diagnosed by doctor	1.5	4.1	8.9	-0.6	-1.6	2.0	2.1	3.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.3	-0.1	1.0	-1.7	-1.8	-1.5
Impedance of whole body	1.5	7.7	13.5	1.5	-1.7	3.7	3.3	3.0
Arm predicted mass (left)	1.5	7.7	12.0	-1.6	1.7	-3.5	-3.3	-3.2
Number of treatments/medications taken	1.4	2.5	4.2	-0.6	0.5	-1.9	-2.1	-2.0
Medication: Ibuprofen	1.4	1.6	2.4	-0.5	1.0	-1.6	-1.5	-1.4
Back pain experienced in last month	1.4	2.0	2.9	0.7	-1.5	1.7	1.6	1.4
Alcohol drinker status: Never	1.4	1.7	2.2	-0.7	1.3	-1.4	-1.5	-1.4
Basal cell carcinoma (self-reported)	1.4	1.7	5.0	2.2	1.2	0.7	0.6	1.0
Mean Putamen Volume	1.3	1.5	2.4	0.1	-1.5	1.2	1.5	1.1
Fed-up feelings	1.3	2.4	5.1	2.3	0.7	1.6	1.4	1.4
Had other major operations	1.3	1.6	2.6	-1.3	0.5	-1.3	-1.3	-1.6
Impedance of arm (right)	1.3	6.1	10.7	1.1	-1.5	3.3	2.9	2.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	6.0	-1.4	-2.4	0.1	0.4	0.7
Alzheimer’s Disease (including proxy)	1.2	1.8	2.9	1.1	-1.1	1.7	1.6	1.1
Ulcerative Colitis (UC)	1.2	2.3	3.2	-1.6	1.2	-1.8	-1.7	-1.4
Allergy	1.2	2.9	4.2	1.9	-0.3	1.8	1.9	2.0
Hair/balding pattern: Pattern 4	1.2	2.8	4.9	-0.1	0.6	-2.2	-2.2	-2.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.3	-1.6	-2.1	0.6	0.8	1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.1	-1.6	-1.8	-0.8	-0.8	-0.1
Illnesses of father: Heart disease	1.2	1.7	3.6	0.9	1.6	-1.0	-0.8	-1.9
Mood swings	1.2	2.2	3.5	1.1	0.5	1.9	1.8	1.7
Pack years of smoking	1.2	1.8	4.3	1.2	2.1	-0.7	-0.8	-1.4
Reaction Time	1.1	2.1	7.3	2.7	1.4	0.6	0.4	0.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	1.3	0.6	1.7	1.4	0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.4	-0.9	-1.5	-1.1	-1.1	-1.1
Supplements: Zinc	1.1	1.2	2.3	-0.9	-0.2	-1.3	-1.2	-1.5
Pack years adult smoking proportion	1.1	1.7	4.2	0.9	2.0	-0.7	-0.9	-1.6
Supplements: Glucosamine	1.1	1.4	1.9	-1.0	1.1	-1.4	-1.3	-1.1
Fluid intelligence score	1.1	2.2	3.1	-0.6	1.7	-1.7	-1.8	-1.4
Happiness	1.1	1.3	2.9	1.7	0.7	1.2	1.1	0.7
Medication: Lansoprazole	1.1	1.2	2.0	0.9	0.6	1.4	1.2	1.3
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.1	1.8	1.3	0.8	0.7	1.0
Gout (self-reported)	1.1	1.5	2.3	-1.0	0.1	-1.4	-1.5	-1.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.8	1.3	1.3	1.1	1.0	1.0
Medication: Gliclazide	1.1	1.2	3.4	-1.5	-1.8	-0.4	-0.4	-0.3
Miserableness	1.1	2.0	3.8	0.7	-0.1	1.9	1.7	1.6
Guilty feelings	1.1	1.6	6.4	0.7	2.5	-0.6	-0.7	-0.6
Tanning	1.0	11.9	39.3	6.3	2.6	2.2	2.3	1.8
Relative age of first facial hair	1.0	2.1	2.9	-1.3	-1.7	-1.4	-1.3	-1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.3	1.5	0.2	1.0	1.0	1.2
Hearing difficulty/problems with background noise	1.0	1.5	2.5	1.1	-0.1	1.6	1.6	1.2
Mouth/teeth dental problems	1.0	1.5	3.0	-1.2	0.1	-1.7	-1.4	-1.0
Pulse rate	1.0	1.8	3.0	-1.2	-1.7	1.2	1.3	1.2
Blood clot in the leg (DVT)	1.0	1.3	4.6	-1.2	-2.1	-0.0	0.2	0.5
Medication: Omeprazole	1.0	1.2	1.9	0.3	1.1	-1.4	-1.4	-1.1
Chest pain or discomfort	1.0	1.4	2.9	-0.3	1.2	-1.1	-1.2	-1.7
Illnesses of siblings: Diabetes	1.0	1.3	2.7	1.7	1.6	0.6	0.7	0.5
Medication: Blood pressure	1.0	2.0	3.8	0.9	1.4	-1.3	-1.3	-1.9
Myopia	1.0	1.5	2.5	0.1	0.5	-1.5	-1.6	-1.5
Age at First Birth	0.9	1.2	2.8	-1.7	0.5	-1.3	-1.1	-0.6
Crohns Disease (2012)	0.9	1.5	3.9	0.5	2.0	-1.1	-1.2	-0.8
Medication for hormone replacement therapy	0.9	1.0	4.5	-0.7	-2.1	0.1	0.1	0.4
Severe depression (siblings)	0.9	1.0	1.6	-1.2	-1.3	-0.8	-0.9	-0.7
Had menopause	0.9	1.1	1.8	-1.0	-0.7	-1.1	-1.1	-1.3
Neuroticism score	0.9	1.8	5.2	1.9	2.3	0.6	0.4	-0.1
Hip circumference	0.9	4.0	5.6	-2.1	0.9	-2.4	-2.1	-2.1
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	-1.1	-1.5	-0.6	-0.6	-1.0
Tense / ‘highly strung’	0.9	1.4	4.4	1.3	2.1	-0.0	-0.5	-1.0
Age at first live birth	0.9	1.6	3.2	-0.5	1.8	-1.3	-1.4	-1.0
Medication: Blood pressure	0.9	1.6	2.5	0.9	1.6	-0.9	-1.1	-1.6
Heart disease (mother)	0.9	1.1	2.6	-1.6	-0.9	-0.8	-0.8	-0.8
Neuroticism (2016)	0.8	1.2	2.4	0.6	0.3	1.5	1.4	1.1
Rheumatoid Arthritis	0.8	1.2	2.9	-0.1	-0.5	-1.1	-1.2	-1.7
Relative age voice broke	0.8	1.3	4.2	-1.2	-2.0	-0.7	-0.4	-0.1
High blood pressure (siblings)	0.8	1.2	4.3	0.7	2.1	-0.3	-0.5	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.6	0.8	-0.7	1.1	1.2	1.3
Pulse wave peak to peak time	0.8	0.9	2.5	1.0	1.6	0.5	0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.8	-1.7	-0.8	-1.2	-1.0	-0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	-1.4	-1.6	0.4	0.3	0.7
Risk taking	0.8	1.1	1.8	-1.4	-1.0	-0.9	-1.0	-0.9
Commuting to job workplace: Cycle	0.8	0.9	2.0	-0.7	0.5	-1.4	-1.2	-0.7
Heart disease (siblings)	0.8	1.0	1.8	0.9	0.9	-0.8	-0.9	-1.3
Depression (Nagel 2018)	0.7	1.0	3.0	1.7	1.0	0.8	0.7	-0.0
Breast Cancer	0.7	1.7	2.6	0.4	-1.6	1.2	1.3	1.6
Bipolar Disorder (2011)	0.7	0.7	1.3	0.2	1.1	-0.9	-0.9	-0.6
Waist Hip Ratio (WHR)	0.7	3.2	4.7	1.2	-1.8	2.2	1.9	1.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	0.7	0.1	1.0	1.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.3	1.8	0.6	0.5	0.3	0.5
Medication: Ramipril	0.7	0.9	2.3	0.9	1.5	-0.7	-0.8	-0.5
Illnesses of siblings	0.7	1.0	2.6	-1.1	-1.6	0.1	0.2	0.9
Alcohol intake versus 10 years previously	0.7	1.1	1.5	1.1	-0.8	1.2	1.0	0.9
Medication: Cholesterol lowering	0.7	1.0	4.3	2.1	0.8	0.3	0.3	-0.3
Peak expiratory flow (PEF)	0.7	1.7	3.8	-0.5	1.4	-1.1	-1.2	-2.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.1	1.8	0.8	0.1	0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.3	1.5	0.2	0.9	0.8	0.5
Medication for pain relief, constipation, heartburn	0.7	1.2	1.8	-0.8	-0.8	1.3	1.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.4	0.5	-1.2	1.0	1.0	0.9
Suffer from ‘nerves’	0.7	1.1	1.8	-0.1	1.0	-1.0	-1.3	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	-0.1	0.1	-1.1	-1.2	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.9	0.1	-1.7	0.7	0.8	0.7
Depressed Affect (Nagel 2018)	0.6	1.2	1.7	1.3	0.8	1.3	1.2	0.8
Neuroticism (Nagel 2018)	0.6	1.4	4.8	1.3	2.2	0.6	0.3	-0.4
Worry (Nagel 2018)	0.6	1.2	3.6	0.8	1.9	-0.2	-0.5	-1.2
Primary Biliary Cirrhosis	0.6	0.9	2.9	0.7	1.7	0.5	0.4	0.8
Blood Red Count	0.6	5.9	10.2	-1.7	0.3	-3.0	-2.7	-3.2
BMI	0.6	3.3	4.5	-0.6	2.1	-2.0	-1.9	-2.0
Cardiovascular Disease	0.6	2.0	5.0	1.0	1.0	-1.2	-1.3	-2.2
Neuroticism	0.6	1.5	3.1	1.7	1.8	0.9	0.8	0.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.2	0.4	1.8	0.3	0.1	0.2
Medication: Co-codamol	0.6	0.7	1.6	-1.1	-0.4	0.5	0.5	1.3
Diabetes (mother)	0.6	0.7	1.9	-1.1	-1.4	0.4	0.4	0.4
Weight	0.6	2.8	4.2	-1.4	1.0	-2.0	-1.9	-1.8
Depression (self-reported)	0.6	0.7	1.7	-1.0	-1.3	0.5	0.5	0.6
Impedance of arm (left)	0.6	3.0	5.5	0.6	-1.3	2.4	2.0	1.9
Standing height	0.6	5.8	9.2	-1.0	1.4	-2.8	-3.0	-3.0
Birth weight of first child	0.6	1.1	2.0	-1.4	-0.8	-0.9	-1.0	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.1	2.9	1.7	1.2	1.5	1.5	1.2
Mean time to correctly identify matches	0.6	1.2	3.7	1.9	1.0	0.4	0.4	0.9
Family relationship satisfaction	0.6	0.7	1.2	1.1	0.9	1.0	0.6	0.4
Long-standing illness, disability or infirmity	0.6	0.8	1.5	-0.8	-0.3	-1.0	-0.9	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	3.0	-0.6	-1.7	0.2	-0.1	-0.2
Pain experienced in last month	0.6	1.0	1.6	-1.3	-0.3	-1.1	-1.0	-1.2
Prostate Cancer	0.5	0.8	2.4	1.0	1.6	-0.4	-0.4	-0.3
Average weekly fortified wine intake	0.5	0.6	1.5	-0.3	1.2	-0.8	-0.6	-0.6
Number of incorrect matches in round	0.5	0.9	1.7	0.3	-1.0	-0.9	-1.0	-1.3
Forced vital capacity (FVC)	0.5	1.8	2.6	1.4	1.2	1.6	1.5	0.9
Worrier / anxious feelings	0.5	1.0	2.5	0.2	1.6	-1.0	-1.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.5	1.1	1.2	-0.1	-0.0	0.0
Glaucoma (self-reported)	0.5	0.5	1.1	0.1	-0.1	-0.8	-1.1	-1.0
Medication: Amlodipine	0.5	0.8	2.0	1.4	1.1	-0.1	-0.3	-0.6
Number of children fathered	0.5	0.5	2.5	-0.2	-1.6	-0.3	-0.3	-0.0
Shortness of breath walking on level ground	0.5	0.6	1.4	-1.2	-1.2	-0.0	-0.0	-0.0
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.1	-0.5	0.8	1.0	1.0
Migraine (self-reported)	0.5	0.6	2.9	-0.1	1.7	0.3	0.4	0.2
Medication: Allopurinol	0.5	0.7	1.1	0.5	-0.1	-1.0	-1.1	-0.9
Friendships satisfaction	0.5	0.6	2.4	0.3	1.5	0.4	0.1	-0.5
Eye problems/disorders: Cataract	0.5	0.6	2.2	-0.3	-1.5	-0.6	-0.5	-0.3
High cholesterol (Self-reported)	0.5	0.8	2.3	1.5	1.0	0.8	0.5	0.1
Irritable Bowel Disease (IBD)	0.4	0.9	3.2	-0.0	1.8	-0.7	-0.7	-0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.3	0.1	0.5	1.1	1.0	0.4
Height	0.4	8.0	13.5	-1.8	1.9	-3.2	-3.1	-3.7
Hypothyroidism (self reported)	0.4	0.9	1.8	-0.1	0.9	-1.3	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.0	0.7	-0.9	-0.7	-0.8	-1.0
Medication: Metformin	0.4	0.6	1.0	-0.1	-0.6	-0.9	-1.0	-0.8
Diabetes (father)	0.4	0.5	0.7	0.2	0.8	-0.8	-0.8	-0.7
Age when periods started (menarche)	0.4	1.0	1.6	-0.8	-0.9	1.0	1.1	1.3
High blood pressure (mother)	0.4	0.5	1.3	0.3	1.1	-0.8	-0.6	-0.6
Time employed in main current job	0.4	0.5	1.2	1.0	1.1	0.1	-0.1	0.4
Number of live births	0.4	0.6	2.2	-0.4	-1.5	-0.6	-0.1	-0.5
Prospective memory result	0.4	0.5	1.5	-0.7	-1.2	-0.7	-0.3	-0.1
Lung cancer (father)	0.4	0.4	1.1	-0.5	-1.1	0.3	0.3	0.7
Headache pain in last month	0.4	0.7	1.5	1.0	1.2	0.5	0.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	1.0	1.5	-0.8	-0.6	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.0	0.8	0.0	0.8	0.8	1.0
Leg fat percentage (right)	0.4	1.6	3.2	0.4	-0.1	1.4	1.6	1.8
Pulse rate, automated reading	0.4	1.4	5.2	-1.1	-2.3	0.6	0.4	0.2
Age at last live birth	0.4	0.6	1.0	-0.9	0.7	-1.0	-0.8	-0.5
Leg pain on walking	0.4	0.5	1.2	-0.4	-1.0	0.2	0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.8	-0.6	0.3	-1.0	-1.3	-0.9
Osteoporosis (self-reported)	0.4	0.4	1.4	-1.2	0.8	-0.4	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	0.1	0.2	1.0	1.1	1.2
Alcohol drinker status: Previous	0.4	0.4	0.9	-0.9	-0.6	-0.6	-0.7	-0.3
Fasting Glucose	0.3	0.4	1.0	0.1	0.1	1.0	0.9	0.5
HbA1C	0.3	0.4	1.3	0.5	-0.4	0.3	0.3	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	-1.2	-0.6	0.3	-0.1	-0.2
Heel T-Score	0.3	2.0	3.5	0.2	-1.9	1.7	1.7	1.0
Respiratory disease	0.3	0.7	1.1	-0.4	0.6	-0.9	-1.1	-1.1
Systolic blood pressure, automated reading	0.3	0.9	1.9	-0.9	0.0	-1.0	-0.8	-1.4
Stomach or abdominal pain in last month	0.3	0.3	0.5	-0.5	-0.7	-0.6	-0.5	-0.4
Diabetes (self-reported)	0.3	0.4	0.8	0.6	-0.7	-0.5	-0.5	-0.9
Medication: Simvastatin	0.3	0.5	1.8	1.3	0.5	-0.1	-0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.0	1.0	-0.4	-0.5	-0.2
Noisy workplace	0.3	0.4	0.8	-0.5	0.3	-0.9	-0.8	-0.2
Illnesses of mother	0.3	0.4	0.8	0.1	-0.6	0.7	0.5	0.9
Pulse wave reflection index	0.3	0.4	1.2	-0.5	-1.1	-0.2	-0.2	-0.7
Birth weight	0.3	0.7	1.4	-1.2	-0.1	-0.8	-0.9	-0.9
Neck or shoulder pain in last month	0.3	0.5	1.1	0.6	-1.0	0.4	0.5	0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.8	-0.8	0.3	0.3	0.3
Comparative height size at age 10	0.3	1.8	3.3	1.1	1.8	-0.8	-1.1	-1.6
Number of full sisters	0.3	0.4	0.7	0.1	-0.5	0.5	0.8	0.8
Overall health rating	0.3	0.6	1.1	0.8	-0.8	-0.2	-0.6	-1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	0.4	-0.2	0.9	0.7	0.3
Supplements: Vitamin C	0.3	0.3	0.7	0.5	0.6	0.9	0.5	0.4
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.6	-0.6	0.5	0.7	0.8
Ever taken oral contraceptive pill	0.3	0.3	1.3	0.3	1.1	0.1	-0.1	0.1
Leg fat percentage (left)	0.3	0.9	1.7	0.3	-0.3	1.1	1.3	1.3
Irritability	0.3	0.6	1.4	-0.4	0.1	1.2	1.0	0.7
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	0.8	0.6	0.4	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.2	-0.6	0.6	0.4	0.3
Crohns Disease (2017)	0.2	0.4	1.3	0.6	1.1	0.1	0.1	0.7
Lupus	0.2	0.3	1.4	-0.3	1.2	-0.1	-0.2	0.1
Triglycerides	0.2	0.3	1.3	1.1	-0.1	0.1	0.4	0.2
Systolic Blood Pressure	0.2	1.2	2.8	-0.9	-0.6	-1.1	-1.1	-1.7
Hand grip strength (left)	0.2	0.5	1.5	0.4	0.6	0.6	0.6	1.2
Sensitivity / hurt feelings	0.2	0.4	1.2	0.5	0.5	-0.4	-0.4	-1.1
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.5	-0.4
Hand grip strength (right)	0.2	0.7	1.7	0.3	0.9	0.6	0.6	1.3
Medication: Atenolol	0.2	0.2	0.5	0.7	0.5	-0.4	-0.2	-0.2
Sitting height	0.2	1.5	3.0	-0.7	0.1	-1.3	-1.5	-1.7
Body mass index (BMI)	0.2	0.7	1.1	-1.0	0.4	-1.0	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	1.0	-0.7	0.7	0.5	0.3
Asthma	0.2	0.4	0.5	-0.6	0.5	-0.5	-0.6	-0.7
Loud music exposure frequency	0.2	0.3	0.4	0.6	-0.7	0.2	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.2	0.4	-0.4	-0.5	-0.7
Medication: Paracetamol	0.2	0.3	0.8	0.9	-0.1	0.3	0.1	0.8
Body fat percentage	0.2	0.8	1.5	-0.2	-0.5	1.0	1.1	1.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	0.0	0.9	-0.6	-0.5	-0.3
Medication for cholesterol	0.2	0.3	0.7	-0.4	0.9	0.3	0.3	0.8
Breast cancer (self-reported)	0.2	0.3	1.0	0.2	0.3	-0.3	-0.5	-1.0
Arm fat mass (left)	0.2	0.7	1.3	-1.1	0.4	-1.0	-0.8	-0.7
Mother’s age at death	0.2	0.2	0.9	0.4	0.9	-0.1	0.2	-0.2
Medication: Paracetamol	0.2	0.3	0.9	0.9	-0.1	0.1	0.0	0.6
Medication: Lisinopril	0.2	0.3	0.5	0.3	0.4	-0.5	-0.5	-0.7
Age started oral contraceptive pill	0.2	0.2	0.5	0.3	0.6	-0.7	-0.5	-0.3
Diastolic blood pressure, automated reading	0.2	0.6	1.5	-0.0	0.4	1.1	1.2	0.0
Ever depressed for a whole week	0.2	0.3	0.5	0.1	-0.3	-0.7	-0.7	-0.6
Major Depression (MDD)	0.1	0.1	0.3	0.5	-0.4	0.3	0.2	-0.2
HDL Cholesterol	0.1	0.2	0.4	0.1	0.6	-0.4	-0.4	-0.2
Blood White Count	0.1	0.4	1.7	1.3	0.1	-0.1	-0.3	0.2
Chronotype (morning person)	0.1	0.3	1.0	0.0	1.0	0.3	0.5	0.2
Hair Pigment	0.1	2.0	7.4	-2.7	-1.5	-0.4	-0.3	0.2
Angina	0.1	0.1	0.5	0.7	-0.1	0.2	0.1	-0.3
Trunk fat percentage	0.1	0.6	0.9	-0.4	-0.7	0.8	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.9	0.1	-1.0	0.1	0.1	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.8	-0.5	-0.9	-0.3	0.1	0.3
Waist circumference	0.1	0.3	0.6	-0.8	0.1	-0.6	-0.5	-0.6
Nervous feelings	0.1	0.3	0.9	-0.3	0.5	-0.1	-0.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.6	-0.5	0.3	-0.1	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.1	0.4	-0.1	-0.1	0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	0.3	-0.4	0.3	0.3	0.3
Heart attack	0.1	0.1	0.4	0.6	-0.1	-0.2	0.0	-0.3
Arm fat percentage (right)	0.1	0.3	0.7	-0.5	-0.2	0.4	0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.6	0.5	1.3	0.4	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	0.6	1.2	0.5	0.5	0.2
Arm fat mass (right)	0.1	0.6	1.3	-1.1	0.1	-0.9	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.1	0.7	-0.0	-0.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.6	0.0	-0.8	0.2	0.4	0.1
Angina (self-reported)	0.1	0.1	0.6	0.8	-0.0	0.2	0.2	-0.2
Alcohol intake frequency.	0.1	0.1	0.3	-0.2	0.0	-0.5	-0.6	-0.4
Medication: Aspirin	0.1	0.2	0.3	0.5	0.3	-0.3	-0.4	-0.3
Knee pain experienced in last month	0.1	0.2	0.6	-0.3	0.8	0.2	0.2	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.8	-0.5	-0.1	-0.2	-0.4
Asthma (self-reported)	0.1	0.2	0.6	-0.2	0.7	-0.3	-0.4	-0.6
Medication: Aspirin	0.1	0.1	0.4	0.7	0.3	-0.2	-0.3	-0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	0.4	-0.1	-0.2	-0.4	-0.6
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.5	0.0	0.6	0.6	-0.0
Medication: Atorvastatin	0.1	0.1	0.3	-0.5	-0.6	-0.1	-0.2	-0.2
Cholesterol lowering medication	0.1	0.2	0.4	0.4	-0.4	-0.2	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.6	0.8	0.0	-0.1	0.1	-0.1
Blood Eosinophil Count	0.0	0.4	0.8	0.5	0.3	0.9	0.7	0.5
Trunk fat mass	0.0	0.1	0.4	-0.7	0.0	-0.2	-0.1	-0.0
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	-0.0	0.1	-0.4	-0.2	-0.2
Whole body fat mass	0.0	0.1	0.4	-0.6	0.2	-0.2	-0.0	0.0
Leg fat mass (right)	0.0	0.1	0.3	-0.1	0.6	-0.1	0.1	0.3
Arm fat percentage (left)	0.0	0.2	0.3	-0.6	0.1	0.2	0.4	0.6
Leg fat mass (left)	0.0	0.1	0.2	-0.3	0.4	-0.5	-0.2	-0.1

Hub : Genes

NDUFAF2

Models

Trait associations