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chr14:103,108,478-105,211,221

Best TWAS P=2.97e-22 · Best GWAS P=7.34e-17 conditioned to 0.453

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PPP1R13B	0.04	0.02	enet	14	0.02	1.3e-03	6.20	-6.4	1.6e-10	0.25	0.37	0.14	FALSE
2	GTEx	Adipose Subcutaneous	MARK3	0.12	0.05	lasso	3	0.06	2.5e-05	-8.32	-6.7	2.8e-11	0.95	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	PPP1R13B	0.04	0.02	lasso	2	0.01	4.1e-02	6.66	-6.9	4.0e-12	0.25	0.26	0.09	FALSE
4	GTEx	Adipose Subcutaneous	ZFYVE21	0.13	0.03	enet	25	0.04	5.0e-04	6.50	6.3	3.6e-10	-0.40	0.60	0.14	FALSE
5	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	5.98	8.0	1.2e-15	-0.64	0.19	0.36	FALSE
6	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	6.11	6.7	2.5e-11	-0.36	0.97	0.03	FALSE
7	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	5.93	-7.5	4.6e-14	0.43	0.27	0.37	FALSE
8	GTEx	Adipose Visceral Omentum	KLC1	0.06	0.02	lasso	2	0.00	2.2e-01	-7.70	8.3	7.8e-17	-0.65	0.13	0.20	FALSE
9	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	6.43	8.3	9.7e-17	-0.64	0.06	0.62	FALSE
10	GTEx	Adrenal Gland	CKB	0.18	0.00	enet	16	0.02	6.9e-02	6.43	6.8	7.2e-12	-0.37	0.07	0.18	FALSE
11	GTEx	Artery Aorta	ZFYVE21	0.10	0.09	lasso	4	0.08	2.9e-05	6.22	6.3	3.5e-10	-0.22	0.25	0.16	FALSE
12	GTEx	Artery Aorta	KLC1	0.10	0.14	lasso	3	0.14	6.1e-08	-7.66	8.2	3.4e-16	-0.66	0.65	0.34	FALSE
13	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	-8.26	-6.9	3.8e-12	0.83	0.03	0.97	FALSE
14	GTEx	Artery Coronary	APOPT1	0.19	0.02	lasso	5	0.05	1.2e-02	6.85	-9.7	3.0e-22	0.53	0.09	0.08	TRUE
15	GTEx	Artery Tibial	ZFYVE21	0.11	0.09	lasso	1	0.08	8.0e-07	-7.71	7.7	1.3e-14	-0.68	0.68	0.30	FALSE
16	GTEx	Artery Tibial	KLC1	0.11	0.08	lasso	3	0.08	1.1e-06	-7.70	7.5	5.5e-14	-0.68	0.66	0.26	FALSE
17	GTEx	Artery Tibial	XRCC3	0.06	0.08	lasso	3	0.03	1.4e-03	6.42	7.8	5.0e-15	-0.38	0.58	0.36	FALSE
18	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	-8.26	-7.9	3.0e-15	0.95	0.02	0.98	FALSE
19	GTEx	Artery Tibial	RP11-73M18.8	0.09	0.06	lasso	4	0.09	7.4e-08	5.93	6.7	1.9e-11	-0.34	0.99	0.01	FALSE
20	GTEx	Artery Tibial	RP11-73M18.6	0.05	0.03	lasso	2	0.02	4.7e-03	5.93	5.9	4.7e-09	-0.30	0.24	0.08	FALSE
21	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	6.56	7.8	7.7e-15	-0.29	0.08	0.58	FALSE
22	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	8.30	-9.0	3.0e-19	0.68	0.05	0.75	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	TDRD9	0.23	0.02	lasso	3	0.05	1.5e-02	6.67	-6.8	8.6e-12	0.29	0.09	0.08	FALSE
24	GTEx	Breast Mammary Tissue	MARK3	0.12	0.11	lasso	2	0.08	3.9e-05	-8.28	-8.3	1.2e-16	0.98	0.02	0.97	FALSE
25	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	6.67	8.7	4.0e-18	-0.49	0.48	0.46	FALSE
26	GTEx	Breast Mammary Tissue (Male)	MARK3	0.08	0.00	enet	9	-0.01	7.2e-01	-8.28	-8.1	8.3e-16	0.86	0.03	0.38	FALSE
27	GTEx	Breast Mammary Tissue (Male)	RP11-73M18.8	0.22	0.12	lasso	4	0.08	7.3e-03	7.45	6.4	1.3e-10	-0.18	0.33	0.07	FALSE
28	GTEx	Breast Mammary Tissue (Female)	KLC1	0.09	0.00	lasso	2	0.00	2.4e-01	5.98	6.9	4.5e-12	-0.35	0.09	0.13	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	PPP1R13B	0.15	0.08	lasso	4	0.07	2.2e-03	6.58	-7.3	2.9e-13	0.27	0.43	0.04	FALSE
30	GTEx	Cells Transformed fibroblasts	ZFYVE21	0.10	0.03	lasso	4	0.11	1.1e-08	-4.18	7.8	6.7e-15	-0.54	0.10	0.82	FALSE
31	GTEx	Cells Transformed fibroblasts	KLC1	0.16	0.11	enet	17	0.10	3.1e-08	5.93	7.1	1.0e-12	-0.45	0.97	0.03	FALSE
32	GTEx	Cells Transformed fibroblasts	APOPT1	0.14	0.12	lasso	3	0.10	6.4e-08	-7.68	-8.4	4.1e-17	0.65	0.69	0.30	FALSE
33	GTEx	Colon Transverse	ZFYVE21	0.12	0.00	lasso	4	0.00	4.7e-01	5.55	7.4	1.8e-13	-0.28	0.10	0.34	FALSE
34	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	6.01	7.6	3.4e-14	-0.60	0.07	0.58	FALSE
35	GTEx	Colon Transverse	XRCC3	0.13	0.14	lasso	4	0.11	1.0e-05	6.42	6.8	1.2e-11	-0.34	0.92	0.02	FALSE
36	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	6.64	5.6	1.8e-08	-0.34	0.25	0.21	FALSE
37	GTEx	Esophagus Gastroesophageal Junction	PPP1R13B	0.09	0.08	lasso	2	0.05	7.9e-03	6.22	-6.3	3.0e-10	0.25	0.27	0.09	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	RP11-73M18.8	0.14	0.07	enet	10	0.10	2.4e-04	5.93	6.9	5.3e-12	-0.34	0.62	0.03	FALSE
39	GTEx	Esophagus Mucosa	KLC1	0.17	0.09	lasso	5	0.12	1.6e-08	6.43	7.2	6.3e-13	-0.39	0.97	0.01	FALSE
40	GTEx	Esophagus Mucosa	XRCC3	0.12	0.15	lasso	2	0.13	4.4e-09	6.43	6.5	5.8e-11	-0.33	0.99	0.00	FALSE
41	GTEx	Esophagus Muscularis	PPP1R13B	0.12	0.07	lasso	5	0.07	3.9e-05	6.61	-6.9	4.5e-12	0.24	1.00	0.00	FALSE
42	GTEx	Esophagus Muscularis	ZFYVE21	0.11	0.06	lasso	5	0.05	5.7e-04	-6.60	7.5	9.5e-14	-0.61	0.32	0.48	FALSE
43	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	-7.70	7.7	1.5e-14	-0.54	0.13	0.37	FALSE
44	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	-8.28	-8.4	3.7e-17	0.95	0.03	0.94	FALSE
45	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	-7.70	-8.7	2.8e-18	0.91	0.04	0.90	FALSE
46	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	-7.68	7.9	2.0e-15	-0.67	0.50	0.23	FALSE
47	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-7.66	8.7	3.1e-18	-0.64	0.74	0.26	FALSE
48	GTEx	Muscle Skeletal	XRCC3	0.06	0.04	enet	13	0.03	1.3e-03	5.55	5.5	4.4e-08	-0.21	0.73	0.03	FALSE
49	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	-6.60	8.0	1.8e-15	-0.74	0.98	0.02	FALSE
50	GTEx	Muscle Skeletal	RP11-73M18.8	0.11	0.14	lasso	7	0.13	8.4e-13	6.30	7.3	2.2e-13	-0.32	0.99	0.01	FALSE
51	GTEx	Nerve Tibial	ZFYVE21	0.08	0.02	enet	12	0.03	2.8e-03	-7.70	5.1	2.9e-07	-0.48	0.09	0.30	FALSE
52	GTEx	Nerve Tibial	KLC1	0.07	0.00	enet	22	0.01	8.5e-02	6.93	7.0	2.4e-12	-0.42	0.13	0.60	FALSE
53	GTEx	Nerve Tibial	XRCC3	0.08	0.06	lasso	3	0.05	3.5e-04	5.93	6.5	8.5e-11	-0.33	0.90	0.05	FALSE
54	GTEx	Nerve Tibial	APOPT1	0.10	0.08	lasso	5	0.06	7.8e-05	6.01	-6.2	6.0e-10	0.35	0.70	0.13	FALSE
55	GTEx	Nerve Tibial	RP11-73M18.8	0.08	0.13	lasso	4	0.10	7.4e-08	5.93	5.3	1.3e-07	-0.27	0.99	0.00	FALSE
56	GTEx	Ovary	EIF5	0.42	0.01	lasso	7	0.10	2.2e-03	-0.42	-5.1	3.1e-07	0.40	0.07	0.21	FALSE
57	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	-8.28	-8.6	9.7e-18	0.97	0.02	0.96	FALSE
58	GTEx	Pituitary	RP11-73M18.8	0.23	0.17	lasso	2	0.13	3.6e-04	5.93	6.0	1.9e-09	-0.33	0.14	0.05	FALSE
59	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	-8.28	-8.6	6.0e-18	0.97	0.02	0.95	FALSE
60	GTEx	Prostate	RP11-73M18.8	0.15	0.29	lasso	1	0.25	5.2e-07	6.43	6.4	1.3e-10	-0.33	0.41	0.08	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	MARK3	0.16	0.10	lasso	3	0.10	6.7e-06	-8.27	-7.3	3.2e-13	0.97	0.02	0.98	FALSE
62	GTEx	Skin Not Sun Exposed Suprapubic	KLC1	0.11	0.09	lasso	4	0.10	4.1e-06	6.50	6.5	5.9e-11	-0.35	0.56	0.27	FALSE
63	GTEx	Skin Not Sun Exposed Suprapubic	XRCC3	0.14	0.03	lasso	14	0.03	1.3e-02	6.43	7.6	4.0e-14	-0.42	0.24	0.70	FALSE
64	GTEx	Skin Not Sun Exposed Suprapubic	CKB	0.28	0.26	lasso	4	0.25	6.4e-14	-5.26	-5.4	7.8e-08	0.72	0.99	0.01	FALSE
65	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	-8.32	-9.0	3.4e-19	0.95	0.02	0.98	FALSE
66	GTEx	Skin Sun Exposed Lower leg	EIF5	0.06	0.03	lasso	4	0.07	2.9e-06	3.35	-6.1	1.3e-09	0.53	0.25	0.38	FALSE
67	GTEx	Skin Sun Exposed Lower leg	KLC1	0.06	0.09	enet	19	0.08	2.2e-07	5.93	7.5	5.9e-14	-0.51	0.75	0.23	TRUE
68	GTEx	Skin Sun Exposed Lower leg	XRCC3	0.09	0.10	enet	16	0.09	6.3e-08	7.26	7.0	2.4e-12	-0.30	0.97	0.03	FALSE
69	GTEx	Skin Sun Exposed Lower leg	CKB	0.43	0.32	enet	16	0.34	5.9e-29	-5.26	-5.6	2.2e-08	0.76	1.00	0.00	FALSE
70	GTEx	Small Intestine Terminal Ileum	ZFYVE21	0.16	0.10	lasso	2	0.13	7.7e-04	6.34	7.3	2.7e-13	-0.27	0.11	0.08	FALSE
71	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	8.30	8.7	3.4e-18	-0.53	0.05	0.49	FALSE
72	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	-8.28	-8.4	6.3e-17	0.98	0.02	0.93	FALSE
73	GTEx	Stomach	TRMT61A	0.12	0.11	lasso	5	0.08	1.2e-04	-8.28	-8.3	1.1e-16	0.98	0.02	0.96	FALSE
74	GTEx	Testis	ZFYVE21	0.11	0.14	lasso	2	0.11	1.4e-05	-7.68	7.7	1.2e-14	-0.68	0.42	0.34	FALSE
75	GTEx	Testis	KLC1	0.17	0.17	lasso	2	0.15	4.4e-07	6.43	6.8	1.4e-11	-0.32	0.87	0.01	FALSE
76	GTEx	Testis	RP11-73M18.8	0.16	0.12	lasso	4	0.12	4.0e-06	6.43	5.9	4.4e-09	-0.22	0.83	0.02	FALSE
77	GTEx	Thyroid	MARK3	0.38	0.48	lasso	4	0.48	2.8e-41	-8.28	-8.3	1.1e-16	0.98	0.02	0.98	FALSE
78	GTEx	Thyroid	PPP1R13B	0.08	0.06	enet	17	0.04	2.8e-04	6.42	6.1	1.1e-09	-0.17	0.85	0.01	FALSE
79	GTEx	Thyroid	KLC1	0.12	0.03	enet	22	0.03	3.6e-03	6.54	7.5	4.5e-14	-0.47	0.37	0.21	FALSE
80	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	6.11	-6.1	9.8e-10	0.36	1.00	0.00	FALSE
81	GTEx	Whole Blood	KLC1	0.16	0.13	lasso	3	0.11	3.6e-10	6.43	6.4	1.6e-10	-0.31	1.00	0.00	FALSE
82	GTEx	Whole Blood	XRCC3	0.08	0.12	lasso	3	0.10	1.3e-09	6.43	6.1	9.1e-10	-0.30	1.00	0.00	FALSE
83	METSIM	Adipose	KLC1	0.06	0.04	enet	22	0.04	7.7e-07	5.93	5.2	2.2e-07	-0.23	0.88	0.10	FALSE
84	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	6.08	-7.9	2.2e-15	0.63	0.06	0.94	FALSE
85	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	6.01	-6.9	4.8e-12	0.43	0.49	0.50	FALSE
86	NTR	Blood	BAG5	0.02	0.00	lasso	5	0.01	6.3e-03	-6.60	6.6	4.7e-11	-0.73	0.27	0.44	FALSE
87	NTR	Blood	KLC1	0.04	0.02	blup	393	0.04	8.2e-12	6.43	5.3	1.4e-07	-0.25	1.00	0.00	FALSE
88	YFS	Blood	KLC1	0.01	0.01	blup	389	0.01	1.0e-03	-6.95	8.9	3.9e-19	-0.76	0.17	0.55	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	-6.60	-7.3	3.3e-13	0.74	0.15	0.79	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKB	0.06	0.03	lasso	3	0.03	2.5e-06	-5.39	-5.5	4.2e-08	0.71	0.50	0.39	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf153	0.07	0.05	lasso	4	0.04	1.5e-03	-7.41	-6.7	1.6e-11	0.70	0.05	0.33	FALSE
92	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	-6.60	-8.5	2.4e-17	0.82	0.01	0.50	FALSE
93	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	-8.27	-9.0	2.7e-19	0.95	0.01	0.54	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MARK3	0.07	0.03	blup	64	0.06	5.5e-07	-5.26	-8.1	4.0e-16	0.81	0.04	0.96	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC3	0.03	0.04	enet	3	0.04	6.1e-05	6.43	6.7	1.6e-11	-0.33	0.50	0.34	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XRCC3	0.06	0.07	lasso	4	0.05	4.6e-04	6.42	5.2	2.0e-07	-0.23	0.10	0.06	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	5.98	-8.4	5.0e-17	0.67	0.08	0.27	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-6.60	-8.4	3.9e-17	0.72	0.07	0.76	FALSE
99	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C14orf153	0.05	0.05	blup	40	0.04	8.6e-06	-7.36	-7.2	7.5e-13	0.77	0.41	0.50	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	6.08	-9.1	6.0e-20	0.79	0.02	0.61	FALSE
101	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	1.20	-5.2	2.2e-07	0.80	0.02	0.53	FALSE
102	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C14orf153	0.15	0.03	blup	37	0.03	1.6e-02	5.93	-5.7	1.1e-08	0.38	0.03	0.08	FALSE
103	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BAG5	0.08	0.09	lasso	2	0.08	3.7e-04	-8.28	-8.3	1.3e-16	0.98	0.00	0.95	FALSE
104	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	-7.41	-7.9	2.6e-15	0.71	0.09	0.59	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	-7.41	-8.7	3.2e-18	0.81	0.10	0.90	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	8.30	-8.8	1.0e-18	0.63	0.01	0.99	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARK3	0.07	0.06	enet	7	0.08	1.0e-08	-5.39	-7.0	2.0e-12	0.88	0.05	0.95	FALSE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	-8.26	-6.0	2.3e-09	0.83	0.01	0.47	FALSE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	XRCC3	0.02	0.01	blup	46	0.01	3.0e-02	6.25	5.8	9.2e-09	-0.18	0.05	0.10	FALSE
110	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	1.61	-5.2	1.9e-07	0.75	0.01	0.38	FALSE
111	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	8.30	-8.8	2.1e-18	0.67	0.00	0.95	TRUE
112	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	6.01	8.5	2.6e-17	-0.51	0.06	0.59	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1R13B	0.04	0.04	lasso	2	0.03	7.9e-04	7.39	7.4	1.3e-13	-0.29	0.06	0.83	FALSE