Best TWAS P=7.79e-19 · Best GWAS P=4.94e-50 conditioned to 3.89e-39
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CAMTA1 | 0.10 | 0.07 | lasso | 3 | 0.07 | 1.9e-08 | 8.9 | -8.9 | 7.8e-19 | 0.00 | 0.99 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PARK7 | 0.05 | 0.00 | bslmm | 423 | 0.01 | 1.2e-02 | -2.1 | 6.2 | 4.2e-10 | -0.04 | 0.16 | 0.13 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -4.9 | 5.6 | 2.5e-08 | -0.03 | 0.96 | 0.02 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | 5.6 | 5.9 | 3.7e-09 | -0.02 | 0.06 | 0.05 | FALSE |
| 5 | GTEx | Lung | SLC45A1 | 0.09 | 0.00 | enet | 13 | 0.04 | 9.7e-04 | -4.7 | -5.5 | 2.8e-08 | 0.03 | 0.45 | 0.02 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | RERE | 0.12 | 0.05 | lasso | 4 | 0.05 | 1.3e-03 | -5.6 | 6.2 | 5.0e-10 | 0.00 | 0.58 | 0.02 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP3-467L1.6 | 0.12 | 0.01 | lasso | 3 | 0.02 | 1.5e-02 | 4.8 | 5.3 | 1.4e-07 | 0.00 | 0.14 | 0.04 | FALSE |
| 8 | METSIM | Adipose | APITD1 | 0.04 | 0.05 | lasso | 3 | 0.03 | 5.1e-06 | 6.4 | 6.5 | 8.8e-11 | 0.01 | 0.98 | 0.01 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CORT | 0.04 | 0.05 | lasso | 6 | 0.04 | 1.7e-04 | 6.0 | -6.0 | 1.5e-09 | 0.00 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -4.8 | 5.5 | 4.2e-08 | -0.06 | 0.93 | 0.01 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APITD1 | 0.05 | 0.02 | blup | 51 | 0.05 | 3.1e-06 | 6.1 | 6.4 | 1.6e-10 | 0.04 | 0.11 | 0.87 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | APITD1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 6.4 | 6.3 | 2.5e-10 | 0.01 | 0.00 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MASP2 | 0.05 | 0.03 | blup | 30 | 0.04 | 6.0e-03 | 5.9 | -8.4 | 3.9e-17 | -0.49 | 0.03 | 0.28 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | APITD1 | 0.02 | 0.02 | blup | 51 | 0.02 | 2.1e-03 | 3.2 | 5.4 | 7.0e-08 | 0.05 | 0.32 | 0.20 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CORT | 0.12 | 0.07 | lasso | 6 | 0.06 | 9.3e-05 | 6.0 | -6.1 | 1.1e-09 | -0.01 | 0.04 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RERE | 0.04 | 0.01 | blup | 154 | 0.01 | 3.1e-02 | -4.4 | 7.2 | 8.9e-13 | -0.06 | 0.06 | 0.03 | TRUE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CORT | 0.06 | 0.03 | enet | 5 | 0.04 | 7.1e-04 | 6.2 | -7.1 | 1.1e-12 | 0.00 | 0.04 | 0.84 | TRUE |