Hub : Genes

CAMTA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0350	3.4e-03	0.069	0.011	0.043	0.062	0.066	8.5e-09	1.4e-02	5.4e-06	4.6e-08	1.9e-08
2	GTEx	Adipose Subcutaneous	0.1080	0.0430	4.6e-03	-0.003	NA	-0.001	NA	-0.003	8.2e-01	NA	4.6e-01	NA	9.9e-01
3	GTEx	Adipose Visceral Omentum	0.2600	0.0900	6.9e-03	0.054	NA	0.058	NA	0.050	9.1e-04	NA	5.6e-04	NA	1.3e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0836	0.0265	1.1e-04	0.031	0.038	0.045	0.057	0.038	5.8e-05	1.1e-05	1.9e-06	7.9e-08	1.1e-05
5	YFS	Blood	0.0656	0.0152	9.9e-09	0.030	0.028	0.041	0.039	0.046	3.7e-10	1.6e-09	1.8e-13	8.9e-13	1.1e-14
6	TCGA	Prostate Adenocarcinoma	0.1125	0.0456	4.0e-03	0.032	0.009	0.017	NA	0.022	2.3e-04	3.5e-02	5.5e-03	NA	2.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.0	1.6	2.4	-1.4	-1.5	-1.5	0.5	1.3	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	2.6	-0.5	0.0	-0.3	1.6	-0.3	0.4
Depressed Affect (Nagel 2018)	0.7	1.4	3.3	0.8	1.5	1.8	-0.7	-0.8	-0.9
Depression (Nagel 2018)	0.4	0.6	2.4	0.4	0.8	0.1	0.4	-1.5	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.1	-1.4	0.1	-0.1	0.5	-0.5	1.4
Neuroticism (Nagel 2018)	0.6	1.4	3.1	1.3	1.8	1.3	-0.7	-1.2	0.5
Schizophrenia (2018)	0.7	1.5	2.7	0.5	1.3	0.7	1.6	-1.5	1.3
Schizophrenia vs Biploar Disorder	1.5	1.9	6.0	-0.2	2.4	0.4	0.1	-2.3	-0.0
Worry (Nagel 2018)	0.7	1.5	4.0	1.1	1.5	0.6	-0.0	-2.0	1.0
Alzheimer’s Disease (in mother)	0.2	0.3	1.4	-0.0	0.5	0.1	-0.0	-1.2	-0.3
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-0.7	-0.0	1.0	1.2	-0.8	-0.9
Alzheimer’s Disease (including proxy)	0.3	0.4	1.9	0.1	0.7	-0.0	0.5	-1.4	-0.1
Crohns Disease (2017)	3.0	6.6	18.7	-0.6	-1.5	-1.3	-4.3	4.1	0.6
Irritable Bowel Disease (IBD)	2.6	6.1	15.6	-2.1	-1.6	-1.8	-4.0	3.3	0.5
Ulcerative Colitis (UC)	1.5	2.8	7.3	-2.7	-1.4	-1.6	-1.7	1.3	0.1
Major Depression (MDD)	1.8	2.2	6.1	-1.0	1.5	1.9	-0.2	0.3	-2.5
Reaction Time	1.1	2.2	11.1	0.1	-0.2	0.6	0.0	-1.2	-3.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.4	-1.2	0.2	-1.3	0.7	-1.5	2.1
Breast Cancer	0.7	1.7	4.3	-0.8	0.9	-1.9	-0.2	0.8	-2.1
Ovarian Cancer	0.8	1.1	3.3	0.6	-1.1	-0.1	0.2	1.8	1.2
Prostate Cancer	1.4	1.9	6.6	-1.6	0.7	1.1	-0.3	0.4	2.6
Age at First Birth	1.8	2.6	5.5	1.2	2.3	1.9	-0.6	-1.0	2.0
Bipolar Disorder (2011)	0.5	0.5	1.3	0.7	-0.7	-1.1	0.2	0.5	0.5
Body Mass Index (BMI) (2010)	0.7	1.0	4.8	-0.8	-2.2	0.0	-0.0	-0.2	0.8
Coronary Artery Disease (CAD)	1.7	2.1	4.8	-1.1	-1.5	-1.2	-1.2	1.1	-2.2
Crohns Disease (2012)	5.2	8.4	23.3	-1.5	-0.8	-0.6	-4.8	4.3	2.4
Mean Putamen Volume	1.1	1.2	3.8	-1.1	-1.2	-2.0	0.3	-0.6	0.5
Fasting Glucose	1.2	1.5	5.1	-2.3	-1.1	0.7	-1.3	0.5	0.3
HbA1C	0.8	0.9	1.9	0.8	-1.4	1.3	-0.8	0.2	0.6
HDL Cholesterol	0.2	0.3	1.4	-0.1	-0.1	-0.8	0.1	1.2	0.3
LDL Cholesterol	0.2	0.3	0.5	-0.6	-0.7	-0.6	-0.2	0.0	0.7
Lupus	0.7	1.0	2.2	-1.1	-0.3	0.6	1.4	-1.5	0.2
Neuroticism (2016)	0.6	0.9	2.3	-1.2	-1.5	-0.0	-0.9	0.8	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.5	-0.5	-0.0	-0.3	0.2	-0.2
Rheumatoid Arthritis	0.8	1.0	4.3	-0.5	-2.1	-0.0	-0.3	1.2	0.5
Schizophrenia (2014)	0.5	1.1	2.0	0.4	1.2	0.2	1.1	-1.2	1.4
Triglycerides	0.5	0.8	1.2	0.7	-0.6	0.8	-1.0	1.1	-1.0
Type 2 Diabetes (T2D) (2012)	2.8	3.3	6.4	-0.9	-2.3	-2.5	-1.6	1.8	-1.1
Ulcerative Colitis	2.3	3.3	10.1	-3.2	-1.0	-0.9	-2.6	0.9	0.4
Blood Eosinophil Count	0.3	2.3	11.5	0.8	-0.6	3.4	0.2	-1.0	-0.6
Blood Platelet Count	2.2	25.9	78.3	-0.6	3.9	5.5	5.5	-8.8	-0.5
Blood Red Count	0.9	9.0	23.0	0.6	3.9	3.0	2.6	-4.8	-0.3
Blood White Count	0.5	4.0	10.2	0.2	1.6	0.9	3.0	-3.2	-1.0
Heel T-Score	1.1	9.1	28.4	-2.0	-5.3	-3.5	2.7	-0.0	-1.6
BMI	0.3	2.0	4.8	-1.0	-1.8	2.2	1.3	0.4	-1.0
Height	0.6	10.9	26.8	2.8	4.1	3.6	0.4	-0.5	5.2
Waist Hip Ratio (WHR)	1.4	6.3	14.4	3.8	1.6	3.4	1.2	-1.4	-2.5
Systolic Blood Pressure	0.4	2.0	8.8	-0.6	-1.6	-0.3	3.0	-0.4	-0.5
Smoking Status	0.6	1.5	4.6	0.7	1.1	-0.8	-0.6	1.4	2.1
Allergy or Eczema	0.2	0.5	1.7	-0.6	-0.3	0.5	-0.7	-1.3	-0.2
Cardiovascular Disease	0.4	1.2	4.2	1.2	-0.6	0.1	0.9	0.7	-2.0
Hypothyroidism (self reported)	0.8	1.8	3.0	1.4	-1.7	-1.0	-1.1	1.2	1.4
Respiratory disease	0.5	1.1	3.9	-0.5	-1.4	0.4	-2.0	0.4	-0.3
Type 2 Diabetes (T2D) (2018)	1.7	3.2	9.5	0.7	-3.1	-1.2	-1.0	1.3	-2.2
Lung FEV1/FVC ratio	0.2	1.2	4.3	0.2	-1.4	-0.1	2.1	-0.4	-0.6
Lung FVC	0.8	4.2	10.3	-1.0	-2.1	-0.5	-1.9	2.4	3.2
Neuroticism	0.8	2.0	4.5	0.7	1.9	1.8	0.3	-2.1	0.2
Chronotype (morning person)	1.9	4.4	17.2	0.6	-0.5	-0.1	4.1	-2.6	-1.3
Hair Pigment	0.6	17.0	78.5	-8.9	0.2	2.6	-3.3	2.0	-1.2
Tanning	0.1	1.8	4.1	1.0	-0.1	-1.4	-2.0	1.9	0.4
Hand grip strength (left)	0.8	2.2	5.7	-1.3	-0.3	-1.0	-1.7	1.3	2.4
Number of treatments/medications taken	1.2	2.1	5.8	0.0	-2.4	-0.9	1.0	-0.2	-2.2
Average weekly spirits intake	2.1	2.6	7.0	-1.1	-1.0	-1.4	-2.2	2.6	-0.2
Sensitivity / hurt feelings	0.4	0.8	2.3	1.3	-0.3	0.2	0.7	-0.0	1.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.8	-0.3	0.2	-1.4	0.5	-0.9	-1.7
Hearing difficulty/problems: Yes	1.7	2.6	7.0	1.1	1.9	0.5	1.1	-2.6	-1.5
Relative age of first facial hair	0.6	1.3	5.0	-2.2	-0.5	-0.4	0.2	-0.9	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	-0.3	-1.1	-0.8	0.9	0.2	-1.2
Ever used hormone-replacement therapy (HRT)	1.1	1.3	5.0	1.3	2.2	-0.6	-0.0	-0.8	0.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.4	0.4	1.1	-0.4	-0.0	0.1	1.6
Systolic blood pressure, automated reading	0.5	1.6	5.1	-1.4	-1.0	0.3	2.3	-1.0	-0.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	4.0	0.5	0.4	-0.2	-0.0	0.9	-2.0
Angina	1.6	2.1	12.2	-0.5	0.4	0.4	0.1	0.1	-3.5
Medication for hormone replacement therapy	1.2	1.4	3.0	1.3	1.2	-0.6	-1.7	1.2	-0.4
Vitamin and mineral supplements	0.5	0.7	1.5	0.9	-1.2	-0.5	0.4	-0.4	-1.2
Supplements: Zinc	0.2	0.2	0.5	-0.4	-0.4	-0.5	-0.4	-0.1	-0.7
Medication: Co-codamol	0.8	1.0	2.2	1.0	0.2	0.5	1.5	-0.6	-1.4
Medication: Metformin	2.5	3.5	11.5	-1.3	-3.4	0.0	-1.1	1.4	-2.2
Diabetes (father)	0.3	0.3	0.8	0.6	0.4	0.5	-0.6	-0.3	0.9
Diabetes (mother)	0.6	0.8	2.5	-0.5	-1.3	-0.2	0.2	0.1	-1.6
Severe depression (siblings)	0.7	0.8	1.9	1.4	0.9	0.4	1.3	0.3	0.4
Pack years adult smoking proportion	0.8	1.2	4.0	-0.1	-0.8	1.3	2.0	-0.4	0.7
Impedance of leg (right)	0.3	1.3	4.6	1.0	0.0	1.0	1.2	0.1	-2.1
Leg fat-free mass (left)	0.3	1.7	6.0	0.4	1.0	1.6	0.8	-0.3	2.4
Trunk fat percentage	0.7	2.8	5.0	-1.5	-0.8	1.6	2.1	-1.2	-2.2
Hand grip strength (right)	1.4	3.9	8.6	-2.8	-1.2	0.1	-2.9	1.3	1.8
Townsend deprivation index at recruitment	0.7	0.9	3.7	0.1	-0.1	0.3	0.1	1.9	-1.4
Current tobacco smoking	0.6	1.0	2.8	0.8	0.4	1.4	1.7	-0.2	0.7
Average weekly fortified wine intake	1.0	1.2	2.6	0.8	0.1	1.4	-1.6	1.4	-0.3
Maternal smoking around birth	0.3	0.4	1.4	0.5	1.2	0.3	-0.1	0.8	0.4
Fed-up feelings	0.6	1.1	4.2	2.0	0.8	1.0	-0.3	0.3	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	0.1	0.3	-0.3	0.1	-0.2	-0.3
Relative age voice broke	0.2	0.4	1.9	-0.1	-0.4	0.1	-1.4	0.4	0.3
Taking other prescription medications	0.7	1.1	3.0	0.8	-1.7	0.9	0.1	-0.4	-1.4
Age when periods started (menarche)	0.3	0.7	1.6	1.3	0.3	1.0	-0.9	0.5	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.2	0.7	0.2	-0.7	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	9.8	-2.4	-3.1	-2.4	2.2	-0.6	0.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	6.6	0.4	2.6	1.5	-0.7	-1.7	-0.2
Qualifications: CSEs or equivalent	0.9	1.2	3.7	1.5	-0.7	0.1	-0.7	0.6	-1.9
Serious illness, injury or assault to yourself	0.2	0.3	0.8	0.5	-0.4	0.4	-0.6	0.2	-0.9
High blood pressure	0.5	1.3	2.3	-1.1	-1.2	0.3	1.4	-0.8	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.3	-1.3	0.2	-1.0	-0.7	0.2
Multivitamins +/- minerals	0.3	0.4	0.9	-0.5	0.9	-0.9	-0.2	0.7	0.2
Stomach or abdominal pain in last month	0.4	0.4	0.9	0.9	0.3	-0.9	-0.5	-0.8	0.3
Supplements: Glucosamine	0.2	0.2	0.9	-0.1	-0.0	0.2	0.9	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-1.1	0.0	-0.1	1.3	-0.7	-0.1
Medication: Atenolol	0.5	0.6	1.2	-0.9	0.6	-0.1	1.1	-0.7	-0.9
Medication: Levothyroxine sodium	0.9	1.5	3.4	1.9	-0.7	-1.4	-0.9	1.4	0.4
Sitting height	0.6	4.5	11.8	1.5	3.4	1.7	-0.4	0.6	3.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	0.6	0.4	1.0	-0.5	0.2	-0.9
High blood pressure (mother)	1.9	2.7	6.3	-2.2	-2.5	0.2	1.6	-1.2	0.8
Body mass index (BMI)	0.4	1.8	4.5	-0.8	-1.1	1.3	2.1	-1.0	-1.4
Impedance of leg (left)	0.3	1.6	7.0	1.2	0.2	0.6	1.0	0.1	-2.6
Leg predicted mass (left)	0.3	1.7	5.8	0.4	1.0	1.6	0.8	-0.3	2.4
Trunk fat mass	0.5	2.0	4.2	-0.8	-0.5	2.0	2.0	-1.1	-1.4
Waist circumference	0.5	1.9	4.9	0.9	-0.3	2.2	1.8	-0.9	-1.3
Number of incorrect matches in round	0.2	0.3	0.6	-0.2	-0.3	0.8	0.8	-0.8	-0.1
Past tobacco smoking	0.8	1.5	3.7	0.4	-1.1	1.4	1.9	-0.8	-1.2
Alcohol usually taken with meals	1.0	1.7	7.3	-1.3	0.6	-0.5	-0.4	-0.5	2.7
Nervous feelings	0.6	1.0	2.9	-0.1	0.7	1.1	0.3	-1.7	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.9	1.4	1.0	-0.2	-0.3	-0.2	0.1
Hearing difficulty/problems with background noise	1.7	2.7	7.7	0.4	2.3	1.4	1.0	-2.8	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.4	-0.1	0.6	-0.0	1.1	-1.2	-0.7
Had menopause	1.3	1.7	5.5	-1.0	2.4	0.9	0.8	-1.0	1.1
Had other major operations	1.4	1.7	3.7	0.8	1.9	1.4	0.6	-1.9	0.2
Forced vital capacity (FVC)	0.8	2.9	15.3	0.5	0.8	1.2	-0.2	-0.0	3.9
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	12.0	-1.9	-3.5	-3.0	1.6	0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	0.4	1.3	0.1	-0.4	-0.3	-1.6
Qualifications: None of the above	2.3	4.8	18.9	1.9	0.2	2.4	0.5	-0.8	-4.3
Financial difficulties in last 2 years	0.8	1.0	3.0	1.7	0.3	0.2	-0.9	1.5	-0.3
Mouth/teeth dental problems	2.1	3.2	10.8	0.3	-0.1	-2.2	-0.4	1.8	3.3
Heart attack	0.8	1.1	3.7	0.1	0.4	0.8	-0.2	1.3	-1.9
Allergy	1.0	2.2	7.4	0.1	2.2	-0.0	2.7	-0.8	0.2
Pain all over the body in last month	0.2	0.2	0.7	0.5	-0.3	-0.4	0.5	0.8	-0.0
Diabetes (self-reported)	3.0	4.6	14.8	-0.1	-3.9	-1.7	-1.1	1.4	-2.7
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.5	-2.1	-0.2	2.4	-0.7	-0.4	0.8
Medication: Ramipril	0.2	0.3	0.7	0.8	-0.1	0.2	0.8	0.7	-0.1
Medication: Simvastatin	1.0	1.5	5.4	1.1	-2.3	-0.1	-0.3	-0.3	-1.5
Fluid intelligence score	0.5	1.0	2.1	-1.0	0.5	-0.7	0.9	-1.1	1.5
Illnesses of siblings	1.2	1.7	3.2	0.1	1.8	0.7	-1.4	1.6	1.5
Neuroticism score	0.6	1.3	2.8	1.6	1.1	0.8	0.5	-1.7	0.4
Weight	0.3	1.3	4.2	0.1	0.2	2.1	1.6	-0.7	0.2
Impedance of arm (right)	0.2	0.7	2.0	-1.1	0.6	-0.3	-1.4	0.8	-0.2
Arm fat percentage (right)	0.5	1.9	3.1	-1.5	-1.2	1.3	1.8	-0.5	-1.7
Trunk fat-free mass	0.5	3.0	5.9	2.1	1.7	1.9	0.9	-0.3	2.4
Hip circumference	0.1	0.4	1.4	-0.2	-0.2	1.2	0.8	0.7	-0.1
Time employed in main current job	0.9	1.0	3.3	-1.0	-1.8	-0.0	-0.4	0.5	-1.1
Alcohol intake versus 10 years previously	0.3	0.4	1.3	0.4	0.8	1.1	-0.2	0.5	0.2
Father’s age at death	0.5	0.7	1.7	0.4	0.7	-0.3	-1.3	0.7	1.2
Worrier / anxious feelings	1.4	2.6	6.9	1.7	2.4	-0.3	-0.3	-2.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	0.7	-0.7	0.5	-1.9	0.5	-1.9
Falls in the last year	0.6	0.8	2.5	-0.6	-0.5	-0.1	1.6	0.6	-1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.8	-0.3	-0.7	1.4	0.1	-0.3	0.2
Number of live births	1.0	1.4	5.1	0.8	-0.8	-1.0	1.0	0.5	-2.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	13.1	1.1	0.4	1.2	0.9	-0.5	3.6
Pulse rate	1.1	1.8	6.5	-2.6	-0.6	-0.9	0.5	-0.2	-1.7
Happiness	0.7	0.8	4.1	0.7	0.3	-0.5	0.0	-0.1	-2.0
Noisy workplace	0.3	0.4	1.2	0.3	1.1	0.3	-0.5	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	1.4	3.0	7.9	-1.4	-0.3	-1.6	-1.6	1.7	2.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	-0.2	-0.8	0.7	-0.6	0.6	0.9
Mouth/teeth dental problems: Dentures	0.5	0.9	4.3	0.7	-0.8	0.1	0.2	-0.2	-2.1
Asthma	1.2	2.4	7.7	-0.3	-2.8	-0.4	-2.1	1.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	1.9	-1.1	0.6	-1.3	-1.4	0.8	-0.7
Medication: Cholesterol lowering	1.3	2.0	8.6	0.2	-2.9	0.5	1.4	-0.9	0.3
Depression (self-reported)	0.5	0.6	1.4	0.0	-0.6	-1.1	0.3	-0.5	-1.2
Medication: Lansoprazole	0.6	0.7	2.9	0.1	-1.1	-1.7	0.2	-0.1	-0.4
Prospective memory result	2.3	2.8	7.8	0.7	-0.5	1.7	2.8	-1.8	-1.4
Lung cancer (father)	1.2	1.4	6.0	-0.6	-0.0	-0.9	-2.4	0.8	-0.6
Illnesses of mother	0.4	0.5	1.4	0.8	-0.5	0.2	-0.8	1.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	10.4	0.9	0.7	1.4	0.3	0.2	3.2
Pulse wave Arterial Stiffness index	1.2	1.3	3.6	-1.2	-0.4	1.6	0.6	0.1	1.9
Impedance of arm (left)	0.1	0.4	1.3	-0.9	0.0	-0.0	-1.1	0.4	-0.6
Arm fat mass (right)	0.4	1.6	3.8	-0.5	-0.6	2.0	1.8	-0.6	-1.1
Trunk predicted mass	0.5	3.1	6.3	2.2	1.6	1.9	1.0	-0.2	2.5
Standing height	0.5	5.1	10.0	2.5	3.1	2.0	-0.8	0.4	3.2
Length of working week for main job	1.3	1.5	5.6	-1.3	-0.6	-0.1	0.9	0.5	2.4
Exposure to tobacco smoke at home	0.7	0.8	3.8	0.7	0.3	-0.4	0.6	-0.3	-2.0
Breastfed as a baby	0.7	0.9	2.4	-1.5	0.0	-1.4	-0.0	0.6	0.5
Tense / ‘highly strung’	0.4	0.7	1.3	0.9	1.1	1.0	-0.6	-0.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	6.5	2.5	0.4	0.1	0.0	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	-0.7	0.4	-0.0	0.6	0.9	0.0
Birth weight of first child	0.4	0.6	1.7	0.6	0.7	1.3	-0.9	-0.6	-0.3
Peak expiratory flow (PEF)	0.6	1.5	5.2	1.6	0.1	-0.5	0.9	-0.2	2.3
Pulse wave reflection index	2.2	2.7	11.2	1.8	-0.8	1.0	0.4	0.5	3.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.7	1.3	0.6	-0.5	-0.5	0.5	-1.6
Loud music exposure frequency	1.6	1.7	4.5	0.5	2.1	2.0	-1.2	0.3	0.2
Qualifications: O levels/GCSEs or equivalent	1.7	2.6	5.6	-2.1	-1.7	-2.4	-1.6	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.0	-0.8	0.2	2.0	0.1	0.5	-1.7
Blood clot in the leg (DVT)	0.6	0.7	1.5	-0.9	-0.9	0.5	-1.2	0.9	-0.5
Medication: Paracetamol	0.7	1.1	2.4	1.4	0.1	-1.4	-0.2	-0.1	-1.6
Headache pain in last month	0.5	0.8	1.7	1.2	1.1	-0.1	-1.3	0.3	-0.9
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	10.4	-0.6	3.2	-0.1	-2.1	0.8	0.2
Glaucoma (self-reported)	0.8	0.9	4.5	0.8	-0.5	-2.1	-0.2	0.3	-0.4
Gout (self-reported)	1.5	2.1	5.4	-1.5	1.2	0.4	-2.3	1.3	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.5	1.6	-0.7	-1.1	-0.0	0.5	0.9
Medication: Amlodipine	0.8	1.2	3.7	-0.8	-0.0	1.9	0.8	-0.5	-1.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.9	-1.4	-0.6	0.0	-0.3	-0.7	-0.7
Birth weight	0.6	1.2	5.4	-0.3	1.0	-0.2	-2.3	0.8	0.6
Chronic bronchitis/emphysema (mother)	2.7	3.1	7.9	1.0	2.8	0.9	-0.0	-1.1	-2.8
High blood pressure (siblings)	1.3	1.9	5.8	0.2	-1.0	0.5	2.4	-2.0	-0.6
Forced vital capacity (FVC), Best measure	0.7	2.4	11.5	0.8	0.8	1.0	-0.6	0.6	3.4
Body fat percentage	0.8	3.1	6.0	-1.4	-1.0	1.9	2.5	-1.2	-2.2
Leg fat percentage (right)	1.2	4.5	11.3	-1.1	-1.3	2.1	3.4	-1.1	-2.6
Arm fat-free mass (right)	0.4	2.2	3.8	1.8	1.1	1.9	1.5	-0.6	1.5
Exposure to tobacco smoke outside home	0.4	0.5	2.5	0.3	0.0	-0.1	-0.5	0.1	-1.6
Comparative body size at age 10	2.8	7.6	18.9	-3.7	-4.3	-2.1	2.9	-0.6	0.6
Number of full brothers	1.8	2.2	7.0	2.6	-1.2	-0.8	1.2	-0.3	-1.6
Worry too long after embarrassment	0.9	1.5	3.2	1.8	1.0	0.2	1.2	-1.2	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.8	0.4	1.7	-0.3	0.5	-0.6	-1.0
Wheeze or whistling in the chest in last year	1.3	2.2	5.4	2.3	-0.9	2.3	0.8	-1.0	-0.5
Number of children fathered	0.5	0.6	2.1	-1.0	0.2	-1.5	-0.2	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.0	-0.1	1.7	-1.7	0.2	-0.7	1.6
Age at first live birth	0.4	0.7	2.6	-0.3	0.8	-0.7	0.2	-0.6	1.6
Pulse wave peak to peak time	0.9	1.1	2.0	1.4	0.6	-1.3	-0.7	-0.1	-1.4
Health satisfaction	1.3	1.6	6.6	0.8	-0.0	-0.1	0.6	-1.5	-2.6
Shortness of breath walking on level ground	0.7	0.8	2.1	0.2	-0.8	0.4	0.7	-1.2	-1.4
Qualifications: College or University degree	1.1	3.5	10.6	-1.4	1.1	-1.8	-0.8	1.9	3.2
Eye problems/disorders: None of the above	1.7	1.9	5.1	-0.6	0.5	1.9	-0.3	-1.4	2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	1.2	0.2	0.7	0.0	-1.1	-0.7
Emphysema/chronic bronchitis	0.6	0.7	1.4	0.1	-1.0	-0.3	0.8	-1.2	-0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	3.8	-0.8	0.4	0.8	-0.2	0.7	1.9
Neck or shoulder pain in last month	0.9	1.3	5.8	0.6	-0.0	-0.1	-1.0	-0.9	-2.4
Medication: Blood pressure	2.0	3.6	10.8	-0.2	-2.3	1.2	3.3	-1.7	-1.0
Angina (self-reported)	1.8	2.4	13.3	-0.6	0.3	0.5	0.5	-0.1	-3.7
Migraine (self-reported)	0.5	0.6	1.2	0.4	1.0	0.5	0.7	-1.1	-0.8
Medication: Ibuprofen	1.6	1.9	5.8	-1.0	-0.1	-1.2	-2.4	1.7	-0.7
Medication: Allopurinol	1.1	1.5	4.2	-1.0	1.1	0.2	-2.0	1.6	-0.2
Medication: Omeprazole	0.2	0.2	0.4	-0.6	-0.5	0.4	-0.4	0.0	-0.7
Medication: Seretide 50 evohaler	0.2	0.3	0.7	0.4	-0.7	-0.8	-0.5	0.3	0.1
Mean time to correctly identify matches	1.2	2.4	12.2	-0.0	-0.7	-0.5	0.1	-1.1	-3.5
Heart disease (mother)	0.5	0.6	1.3	0.7	0.9	-1.1	0.6	-0.3	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.5	2.1	-0.3	-1.5	0.9	0.4	0.8
Whole body fat mass	0.5	2.2	5.3	-0.6	-0.6	2.3	2.1	-0.9	-1.3
Leg fat mass (right)	0.7	2.9	8.9	-0.4	-0.6	2.3	3.0	-1.1	-1.2
Arm predicted mass (right)	0.5	2.6	4.3	1.9	0.9	2.1	1.9	-0.9	1.6
Pulse rate, automated reading	0.6	2.0	5.2	-2.3	-2.0	-0.8	-0.8	0.6	-0.9
Alcohol intake frequency.	1.4	3.1	9.2	0.8	-0.1	2.6	3.0	-1.2	-0.7
Comparative height size at age 10	0.1	0.4	1.4	-0.1	0.3	0.3	-0.7	0.3	1.2
Number of full sisters	1.4	1.7	6.7	0.4	-1.0	-0.7	2.6	-1.2	-0.6
Suffer from ‘nerves’	0.2	0.3	0.7	-0.1	-0.5	-0.8	0.2	-0.6	0.8
Overall health rating	1.3	2.7	8.1	1.9	0.3	0.3	1.4	-1.6	-2.9
Chest pain or discomfort	2.3	3.3	15.2	0.9	-1.4	-1.2	0.1	-0.6	-3.9
Had major operations	0.2	0.2	0.5	-0.7	0.3	-0.3	-0.7	0.1	-0.0
Age at last live birth	1.1	1.5	5.0	-2.2	-0.2	-0.6	1.0	-1.0	1.3
Family relationship satisfaction	1.6	2.0	3.3	1.8	1.7	1.2	1.2	-0.8	1.6
Leg pain on walking	0.4	0.5	2.2	0.1	-0.4	-0.2	0.7	-0.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.9	-0.9	-0.9	1.7	-0.5	0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.3	-1.2	-0.6	0.5	-0.4	-0.2	-1.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.1	-0.5	0.4	1.0	0.5	0.0	0.1
Medication: Aspirin	0.4	0.5	1.9	-0.0	0.0	-0.4	0.8	-0.7	-1.4
Supplements: Vitamin C	1.1	1.3	5.5	-0.9	0.7	1.0	-2.3	0.3	-0.0
Knee pain experienced in last month	0.8	1.2	1.8	1.3	-0.9	-0.6	-1.1	1.3	-1.1
Hypertension (Self-reported)	0.5	1.3	2.1	-1.2	-0.9	0.6	1.4	-0.8	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.4	1.2	0.2	-0.2	0.1	-0.2	0.1
Illnesses of father: Heart disease	0.2	0.3	1.2	-0.5	-0.2	-1.1	-0.2	-0.5	-0.2
Illnesses of siblings: Diabetes	0.9	1.1	4.8	-0.3	-2.2	0.7	-1.1	0.4	-0.1
Smoking status: Previous	1.4	2.0	3.4	-1.1	0.3	-1.7	-1.9	1.1	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.5	0.2	0.6	-0.0	0.2	0.7
Whole body fat-free mass	0.4	2.4	5.9	1.6	1.4	1.7	1.1	-0.4	2.4
Leg fat-free mass (right)	0.3	1.5	6.1	0.4	1.1	1.2	0.5	-0.3	2.5
Arm fat percentage (left)	0.6	2.5	4.0	-1.4	-1.4	1.6	2.0	-0.9	-1.9
Average weekly red wine intake	1.1	1.6	3.2	-1.8	1.7	0.0	1.0	-1.5	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.1	-0.5	-0.0	0.3	0.3
Mood swings	1.0	1.7	3.6	1.3	1.9	1.6	0.6	-1.3	-0.6
Loneliness, isolation	0.7	0.9	2.7	0.8	0.9	1.6	-0.0	-0.1	1.1
Long-standing illness, disability or infirmity	1.3	2.0	6.9	1.0	-0.5	0.7	1.6	-1.0	-2.6
Ever had bowel cancer screening	0.8	1.0	3.5	-0.9	-0.4	-0.7	-1.9	0.6	0.7
Diabetes diagnosed by doctor	2.0	3.2	11.2	0.5	-3.3	-0.4	-0.3	0.8	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.1	-0.0	-0.3	1.1	-1.9	2.3	-0.9
Friendships satisfaction	0.4	0.5	1.9	0.6	1.4	0.5	0.4	-0.5	0.1
Qualifications: nursing, teaching	1.4	2.2	6.5	-1.3	1.1	-0.6	1.2	-1.3	2.6
Commuting to job workplace: Walk	1.1	1.1	3.1	0.5	0.8	1.8	-0.5	-1.1	-1.1
Eye problems/disorders: Cataract	1.1	1.3	3.8	1.3	-0.6	-2.0	0.5	1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.3	-1.3	-0.1	1.3	0.2	-2.3	-1.0
Medication for cholesterol	1.0	1.6	5.0	0.3	-0.8	0.8	1.4	-1.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.3	0.8	-1.8	-1.4	0.2	0.2	-0.5
Back pain experienced in last month	1.4	2.0	7.1	0.4	-0.6	2.7	-0.6	-0.7	-1.9
Mineral and other dietary supplements	0.8	1.1	2.0	0.8	-1.4	-0.4	-0.8	1.4	-1.1
Breast cancer (self-reported)	0.8	0.9	1.9	-0.4	-0.5	0.3	-1.1	1.3	1.4
Asthma (self-reported)	1.1	2.2	7.5	-0.3	-2.7	-0.3	-2.0	0.9	0.4
Osteoporosis (self-reported)	1.1	1.4	3.1	0.6	1.8	1.4	1.4	-1.0	0.2
Osteoarthritis (self-reported)	0.6	0.8	2.7	1.6	0.6	-0.0	0.1	-0.2	-1.3
Medication: Aspirin	0.6	0.8	3.1	-0.2	-0.4	-0.5	1.1	-0.2	-1.8
Medication: Gliclazide	1.4	1.5	3.2	0.3	-1.8	-0.1	-1.7	0.9	-1.4
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	0.1	-0.5	-0.7	-0.1	1.3	1.3
Smoking status: Current	0.7	1.1	2.3	1.1	0.7	1.2	1.5	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.7	-1.1	-0.6	-0.2	-1.2	1.7	1.2
Whole body water mass	0.4	2.3	5.5	1.5	1.4	1.7	1.0	-0.3	2.4
Leg predicted mass (right)	0.3	1.6	6.1	0.4	1.1	1.2	0.5	-0.3	2.5
Arm fat mass (left)	0.4	1.7	4.1	-0.5	-0.9	2.0	1.9	-0.7	-1.2
Number of self-reported non-cancer illnesses	1.4	2.5	5.9	1.4	-0.8	0.3	1.8	-2.4	-1.8
Average weekly champagne plus white wine intake	0.6	0.8	1.5	-0.8	-0.4	-0.8	-1.2	0.8	-0.9
Miserableness	1.6	2.7	9.5	1.0	1.5	-0.0	-0.7	-1.7	-3.1
Guilty feelings	1.5	2.3	10.6	-0.3	3.2	-0.2	0.4	-1.2	1.2
Wears glasses or contact lenses	1.4	1.6	3.4	-1.0	0.3	-1.8	-1.5	1.6	-0.4
Ever taken oral contraceptive pill	1.1	1.2	5.0	0.5	-0.3	0.4	2.2	-1.1	-0.7
Hearing aid user	0.8	0.9	3.1	0.2	-1.8	0.1	1.1	-0.4	-0.9
Mother’s age at death	1.5	1.9	9.6	0.2	3.1	0.9	-0.6	-0.3	0.6
Financial situation satisfaction	0.6	0.7	1.1	0.7	-0.2	-0.8	-1.1	0.9	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.1	0.1	-0.5	0.2	1.0	-1.8	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.9	1.0	0.7	-0.2	-0.0	0.6	0.5
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	0.4	-1.1	-1.1	0.1	0.1	-0.0
Medication: Blood pressure	0.5	1.0	4.1	-1.3	0.4	-0.1	-0.2	-0.0	-2.0
Pain type(s) experienced in last month: Hip pain	1.1	1.3	3.2	1.8	0.1	1.8	0.8	-0.6	-0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.1	-0.8	2.0	1.2	0.1	-1.2	1.1
High cholesterol (Self-reported)	0.5	0.8	1.9	0.9	-1.2	-0.1	0.6	-0.8	-1.4
Medication: Bendroflumethiazide	0.4	0.6	2.5	-1.6	0.7	0.3	0.6	-0.4	-0.2
Medication: Paracetamol	0.7	1.1	4.1	1.4	-0.1	-2.0	-0.0	0.0	-0.8
Medication: Lisinopril	1.1	1.5	2.2	-1.0	-1.4	0.2	1.4	-1.1	-1.5
Medication: Atorvastatin	1.0	1.2	2.4	-1.0	0.4	1.4	1.3	-0.4	1.5
Illnesses of father: High blood pressure	0.6	0.7	2.7	-0.7	-0.9	-0.5	0.3	-0.2	-1.6
Alcohol drinker status: Never	1.0	1.2	3.1	1.2	0.8	1.8	1.1	-0.7	0.2
Ever smoked	0.6	1.1	2.2	-0.7	1.0	-0.7	-1.5	0.6	1.4
Basal metabolic rate	0.3	1.9	3.6	1.2	1.1	1.9	1.3	-0.5	1.8
Leg fat percentage (left)	1.2	4.2	10.8	-1.0	-1.0	2.0	3.3	-1.1	-2.7
Arm fat-free mass (left)	0.4	2.2	5.1	1.2	1.0	2.2	1.7	-0.4	1.7
Number of operations (self-reported)	0.3	0.4	1.5	0.1	-0.6	0.8	-1.2	0.4	-0.1
Average weekly beer plus cider intake	1.6	2.3	4.1	1.0	2.0	1.2	1.4	-1.6	-1.8
Irritability	0.3	0.5	0.9	0.9	0.5	0.9	-0.7	0.4	0.7
Risk taking	1.1	1.6	4.5	1.9	1.2	2.1	0.1	-0.0	0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.2	0.3	1.0	1.5	-0.2	-0.3	0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.5	-0.2	0.3	0.0	0.5	-1.2	-0.5
Age started oral contraceptive pill	0.7	0.8	1.7	0.2	-1.0	1.0	0.8	-1.3	-0.7
Diastolic blood pressure, automated reading	0.9	2.8	7.8	-1.1	-0.3	1.4	2.8	-2.1	-1.0
Ever depressed for a whole week	0.6	0.8	2.9	0.6	0.9	0.5	-0.2	0.7	-1.7
Unable to work because of sickness or disability	0.7	0.9	2.2	0.6	-1.5	-0.0	0.3	0.6	-1.5
Commuting to job workplace: Cycle	0.7	0.8	2.2	-0.1	-0.9	-1.5	0.5	0.3	-1.2
Myopia	1.6	2.3	8.0	0.2	0.1	-1.6	-2.8	1.9	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.4	1.0	0.4	-0.1	-0.7	0.4	2.1
Cholesterol lowering medication	0.8	1.2	6.7	-0.5	0.5	-0.2	-0.1	-0.2	-2.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	0.3	-0.4	0.8	0.7	-0.9	-0.4
Pain experienced in last month	0.7	1.2	3.4	-0.9	-0.1	-0.9	1.5	0.4	1.8
Supplements: Calcium	0.3	0.3	0.5	0.0	0.7	0.5	0.5	0.7	0.6
Basal cell carcinoma (self-reported)	1.7	2.1	7.6	1.2	-0.2	0.8	-1.5	2.8	0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.5	-0.3	0.5	0.7	-0.2	1.2	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.0	-0.9	-1.2	0.5	-1.4	1.1	-0.3
Heart disease (siblings)	0.6	0.8	2.3	0.3	-0.3	-1.2	-0.8	-0.1	-1.5
Alcohol drinker status: Previous	0.6	0.7	3.4	-0.4	0.2	-0.7	1.9	-0.0	-0.5
Pack years of smoking	0.5	0.8	2.9	-0.3	-1.0	0.3	1.7	-0.4	0.5
Impedance of whole body	0.1	0.5	2.7	-0.2	0.1	0.0	-0.3	0.3	-1.6
Leg fat mass (left)	0.7	2.7	8.2	-0.4	-0.6	2.1	2.9	-1.1	-1.3
Arm predicted mass (left)	0.4	1.9	3.8	1.5	1.0	2.0	1.5	-0.2	1.5